Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
ZNRF3 FZD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 23151663 22575959
GSK3A AXIN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219669 17318175
GSK3B AXIN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219694 17318191
GSK3B CTNNB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219694 17318191
GNAQ GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20399743
LRP5 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21606194
CSNK1A1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19293931 22083140
GSK3B SMO â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15803137 23331499
KLHL12 DVL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
LRP6 DVL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 16273260 23371553
DVL2 ATN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
DVL2 NKD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 16273260 21490931
DVL2 CSNK1E â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
DVL2 DIXDC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8080275 20823832
DVL2 RHOA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11779461 18162551
DVL2 DAAM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11779461 18162551
LRP6 DVL2 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 16273260 23371553
DVL2 PI4K2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19561074 23331499
GNAQ GNB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25675501 15889144
SMO GNB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23074268 16885213
WNT3A AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10428961 8666229
SMAD2 ANAPC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
DVL1 APC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20224554 10330181
NOTCH1 ARRB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22162134 16284625
SMO ARRB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15618519 23074268
ARRB1 SMO â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 15618519
PSMA3 ATN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
WWP1 ATN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
AXIN1 SMAD7 â—¼   COLOCALIZATION 2.0 0.8 intact 16601693 5218493
FZD5 AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10428961 8666229
CCP110 CETN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16760425
DVL3 CSNK1D â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
CSNK1E SMO â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 20708941
DVL3 CSNK1G1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 10535959
CSNK1G1 LRP5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16341016 23331499
CSNK2A1 CSNK2B â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
CTNNB1 WWTR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8383887 22234184
SMAD7 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15684397 1568439
CTNNB1 FZD7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12095419 15473860
NKD1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21490931
SIRT1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 27776347 28583374
SMAD7 CXXC5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
CXXC5 SMAD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
DAAM1 DVL1 â—¼   COLOCALIZATION 2.0 0.8 intact 22705156 8379817
DVL1 USP13 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
DVL1 TFDP1 â—¼   COLOCALIZATION 2.0 0.8 intact 22773187 8403810
FZD3 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22944199 19388021
FZD2 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23151663 19388021
FZD4 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 27096005 19388021
DVL1 PI4K2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19561074 23331499
DVL1 ROCK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15121866 23331499
KLHL12 DVL3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
DVL3 SIRT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0911325107 20439735
JUN FBXW7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21460851 20638938
WNT5A FZD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 19910923 19582886
FZD3 VANGL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 21983142 16687519
SCYL2 FZD5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19643732
FZD7 WNT5A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20457807 24865425
WNT8A FZD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 10097073
SMO GNAI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23074268 16885213
GNAQ PLCB1 â—¼   PHOSPHOLIPASE ✅ 2.0 0.8 Reactome 11015615 2841328
NOTCH1 ITCH â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8313469 19567869
PI4K2A ITCH â—¼   COLOCALIZATION 2.0 0.8 intact 23146885 8426259
JUN SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22610349 23161884
WNT1 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18495817
POFUT1 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12697902 12909620
NOTCH1 WNT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18495817
NOTCH1 NOTCH4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22330899 22363130
SMAD1 NOTCH2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD2 ROCK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD3 SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22610349 23161884
WWTR1 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21084559 18568018
WWTR1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21084559 18568018
SMAD4 TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12150994
LRP5 AXIN1 â—¼   RELOCALIZATION ✅ - 0.8 0.8 Signor 11336703
GSK3B SMAD1 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 18045539 25241761
DAPLE DVL1 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 14750955 26126266
STAU1 CDC42 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 15121898 31478661
SMAD1 DVL1 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 12650946
LRP6 AXIN1 â—¼   RELOCALIZATION ✅ - 0.81 0.81 Signor 18632848
DVL1 DVL2 â—¼   PHYSICAL_INTERACTION 817.0 0.81 STRING 36370105
LRP6 WNT1 â—¼   PHYSICAL_INTERACTION 817.0 0.81 STRING 36370105
GNAI3 GNB2 â—¼   PHYSICAL_INTERACTION 819.0 0.81 STRING 36370105
YAP1 GSK3B â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 24976009 29789528
DVL2 CSK21 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 10806215 31340145
RNF43 CSK21 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
LRP6 CTNB1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31262711 16890161
RHOA CTNB1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31871319 31980649
DVL1 APC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 11425858 20224554
ARRB1 ITCH â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 18544533 17947233
CDC42 DAAM1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31871319 16630611
DVL1 SMAD4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 12650946
LRRK2 MSH2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31046837 24725412
LRRK2 RHOA â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 21454543 31046837
SMAD1 NEDD4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 15231748 21308777
PROC WNT5A â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
RNF43 DVL2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 25891077 32103169 25825523 32965059
KC1E DVL3 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 25416956 25910212 10535959 32296183
SMAD4 JUN â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 25609649 10220381
LRP6 WNT3A â—¼   PHYSICAL_INTERACTION 833.0 0.83 STRING 36370105
DAAM1 RHOA â—¼   PHYSICAL_INTERACTION 833.0 0.83 STRING 36370105
AXIN1 DVL3 â—¼   PHYSICAL_INTERACTION 834.0 0.83 STRING 36370105
CTNNB1 SMAD3 â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
GSK3A CTNB1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 17510365 25897075 26496610 27684187
DVL1 CSK21 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 25241761 10806215
SMAD3 CTNB1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 22241478 27684187 20571128 12000714 21965288
DVL3 CTNB1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 10644691 10806215
DVL1 CTNB1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 25241761 10806215
SMAD2 CTNB1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 20571128 23246962 27684187 12000714
DVL1 SMAD3 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 12650946
DVL1 SMAD7 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 12650946
SMAD1 SMAD3 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 15761153 9111321 18729074
GSK3B CTNNB1 â—¼   PHOSPHORYLATION ✅ - 0.84 0.84 Signor 16293724
CTNB1 SMAD7 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 18593713 15684397
GNAI3 DAPLE â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 25416956 26126266 32296183
LRRK2 CDC42 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 21048939 21454543
DAAM1 DVL1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 22705156 11779461
PLK1 DVL3 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 32707033 25659891
WNT1 LRP6 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 11448771 11029007
CSNK2A1 SIRT1 â—¼   PHYSICAL_INTERACTION 855.0 0.85 STRING 36370105
TSC2 GSK3B â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 16959574 12511557
LRRK2 DVL2 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 31046837 19625296
DVL2 PLK1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 32707033 25659891 31340145
DVL2 APC â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 26496610 20224554
APC CDC42 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 17145773 21311754
SMAD7 AXIN1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 18593713 16601693
YAP1 AXIN1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 24976009 29789528
AXIN1 CSNK1A1 â—¼   PHYSICAL_INTERACTION 860.0 0.86 STRING 36370105
PLK1 DCTN1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 12852857 34079125
HECW1 DVL1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 14684739 16713569
LRP6 FZD8 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 15908424 11448771 11029007
RAC1 LRRK2 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 21454543 31046837
SMAD3 NEDD4 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 19953087 15496141 21685363 32296183
ITCH JUN â—¼   PHYSICAL_INTERACTION 869.0 0.86 STRING 36370105
LRP6 GSK3A â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 30824926 16365045
RNF43 KC1E â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 32965059
BUB1 APC â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 11283619 25241761
ITCH ATN1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 9647693 16713569
LRRK2 LRP6 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 22899650 27013965
SMAD4 SMAD7 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
GSK3A FRAT1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 23602568 26496610 10481074
GSK3B SMAD3 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 21310903 18172167
DVL2 ARRB1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11742073 16189514 16713569
APC CSK21 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 25241761 11972058
YAP1 CTNB1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 24976009 23245941 27173435 27684187 33643786 21376238 29789528
DVL1 KLH12 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 32574548 32296183
CDC42 RAC1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 31871319 9427749
YAP1 CTNNB1 â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 22234184 8383887
NOTCH1 FBXW7 â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 23022380
SMAD2 SMAD1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 28205554 28628118 9111321 18729074
FBXW7 JUN â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
CSNK2A1 CSNK2A2 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
FRAT1 GSK3B â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
CTNNB1 YAP1 â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
GSK3B LRP6 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 19107203 16890161 16365045
DVL2 WWP1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 26701932 31340145 34139860
KC1E AXIN1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 26496610 22682247 21988832 11884395
KC1E APC â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 29045831 25241761 11487578 15327768 11425858 17218255
DVL3 CSK21 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 28514442 32296183 10806215
SMAD2 DAB2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 16713569 11387212
PLCB1 GNAQ â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 16754659 11753430 12193606
SMAD2 JUN â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 11371641 10220381 25609649 20195357
SMAD2 SMAD3 â—¼   PHYSICAL_INTERACTION 899.0 0.89 STRING 36370105
WNT3A ZNRF3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 23847203 20495530 22575959
ZNRF3 FZD4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 23847203 20495530 22575959
ZNRF3 LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 23151663 22575959 36131013
GSK3B FZD5 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
GSK3B GNB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
GSK3B FRAT1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 23455922 26496610 12095675 11738041 29568061 23602568
CSNK1D GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21316585 23331499 11818547
DVL1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10428961 16914735 20837657
GSK3B ROR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21078818
DVL2 CXXC4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11113207 15108311 10944533
DVL2 CCDC88C â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 14750955 21031079 22643886
ANKRD6 DVL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 20006983
RYK DVL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15454084 23331499
GNB2 ANXA7 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
DVL1 KC1E â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11425858 11818547 11487578
CSK21 JUN â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 25609649 9685505 1516134 12628923
AXIN1 CTNB1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 29045831 23892894 9734785 26496610 10228155 16199882 22682247 16890161 20128690 27902311 12805222 29789528 22509369 17318191 20531388 19131971 23959799 19223551 32533114 17510365 12421363 18632848 24976009 21242974 30181396 19166851 18593713 34079125
WNT3A RNF43 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 23847203 20495530 22575959
WNT3A LRP5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25425204 21078818 15578921
WNT3A FZD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21078818 18212053 10601008
ANAPC2 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19805045
ANXA7 DVL1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
ANXA7 MSH2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
AXIN1 APC â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 20128690 29045831 29713058 9734785 19131971 10811618 26496610 23277359 10228155 16199882 17510365 22682247 18786926
CSNK1A1 APC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17910481 12628243 11487578
AXIN1 SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16601693
DVL3 CCDC88C â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 14750955 21031079 22643886
CSNK1D WWTR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 24715453
CSNK1D LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 23778311 20229235
CSNK1E ROR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18848778 23331499 15375164
CSNK1E WWTR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 24715453
CSNK1G1 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9214626 10409711 10806215
PROC CSNK2B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
NOTCH3 CSNK2B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CSNK2B STAU1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
YAP1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23607968 22234184 23245941
DVL3 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10644691 10806215
DVL3 CXXC4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11113207 15108311 10944533
DVL3 DAB2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 12805222 16189514 16713569
SMAD3 DAB2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 16189514 16713569 11387212
FZD7 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14636582 22179044 19388021
DVL1 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20006983 23331499 18347071
DVL1 PI4K2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19561074
RYK DVL3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15454084 23331499
DVL3 RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 12533515
DVL3 LRRK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 20006983 19625296
RNF43 FZD4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 23847203 20495530 22575959
FZD5 LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12857724 18077588
WNT8A FZD8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 28733458 10097073
ITCH SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15350225 23331499
SMAD3 JUN â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 10903323 10220381 11306568 21829441 9732876
SMAD4 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12374795 10022869
SMAD3 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12374795 10022869
JUN SMAD7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15579469 10843994
JUN NOTCH4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23917222 21679465 17220278
WNT8A LRP5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23209147 15578921 32196115
LRP6 RNF43 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 23847203 20495530 22575959
NOTCH1 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14597575 23331499 14500836
SMAD2 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18729074 9111321
SMAD7 SMAD4 â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 11279127 15265520 23784029
YAP1 SMAD7 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 12118366 22921829 25283809
APC GSK3B â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
AXIN1 GSK3A â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
CTNNB1 GSK3A â—¼   PHYSICAL_INTERACTION 916.0 0.91 STRING 36370105
AXIN1 LRP6 â—¼   PHYSICAL_INTERACTION 916.0 0.91 STRING 36370105
CSNK2A2 CSNK2B â—¼   PHYSICAL_INTERACTION 0.91 0.91 HuRI 32296183
RHOA ROCK1 â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
CTNNB1 AXIN1 â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 5219694 17318191
FBXW7 NOTCH1 â—¼   PHYSICAL_INTERACTION 949.0 0.94 STRING 36370105
KC1E DVL2 â—¼   PHYSICAL_INTERACTION 0.95 0.95 HIPPIE 23455922 31340145 16713569 32707033 16189514
DVL1 DVL3 â—¼   PHYSICAL_INTERACTION 0.95 0.95 HIPPIE 32296183 10330181
SMAD4 SMAD1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 17183365 5219486
DVL3 KLH12 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 32296183 16547521 16713569 32032490 16189514
CTNNB1 APC â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 36950384
SMAD1 SMAD4 â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
SMAD7 YAP1 â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
CTNNB1 GSK3B â—¼   PHYSICAL_INTERACTION 969.0 0.96 STRING 36370105
GSK3B CTNB1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 11251183 29045831 11835406 10228155 16365045 31286874 23602568 10074433 18687691 33431799 34352208 19061640 27902311 27684187 29568061 29789528 21743491 17318191 25897075 30923315 12051714 11818547 26359353 12114015 10330181 17510365 19107203 12000790 24451375 19303846 16039586 25241761 30181396 11193155 8638126 19576224 30711629
ROCK1 RHOA â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 31871319 14660612 31431478 8816443 21281639 8798490 12773565
RB1 TFDP1 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
SMAD1 YAP1 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
CSNK2B CSNK2A1 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 36833176
AXIN1 DVL2 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
APC CTNB1 â—¼   PHYSICAL_INTERACTION 0.99 0.99 HIPPIE 33961781 11251183 29045831 21664290 15327768 26496610 22682247 12628243 11972058 11533658 16510874 8259519 9707618 27902311 27684187 17318191 15327769 10773885 22056988 9482734 33858476 32533114 17510365 16212417 9286858 15525529 12000790 15355978 10545404 11707392 23840886 25241761 8638126 11712088 11166179 19576224 7890674 34079125
AXIN1 CTNNB1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
AXIN1 GSK3B â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
APC CTNNB1 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
CSNK2A1 CSNK2B â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
SMAD2 SMAD4 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
SMAD3 SMAD4 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
AXIN1 GSK3A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9501208 9601641 9482734 11707456 10196136 17318175
PPP2R5D GSK3A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19131971 10026142 10995457 18042541 18559511 16680151
GSK3A TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 16959574 20226003
GSK3A CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 9601641 9482734 12051714 12000790 11818547 12114015
GSK3A LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 24642411 21606194 21709260 14731402 20229235 30824926 16365045 19366350 21406690 17318175
GSK3A JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 1846781 24214991 91332050 1516134 1956339 16023596 92065884 1651323
DVL1 GSK3B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
DVL2 GSK3B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
WNT1 GSK3B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
GSK3B DVL3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
GSK3B FZD2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
GSK3B WNT3A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
GSK3B WNT8A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
GSK3B FZD1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
GSK3B WNT8B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
PPP2R5D GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19131971 10026142 10995457 18042541 18559511 16680151
FRAT1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 23331499 11738041 23602568 10428961 18498136 26496610 9635432 16982607 12095675 23455922
GSK3B NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 16944320 15465828 12123574 11967263 14663202 8524413 21828089 16713569 9832503 15020233
GSK3B NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 28.0 1.0 Omnipath 16944320 15465828 11967263 14663202 8524413 20068231 12794074 21828089 17570479 9832503 15020233 18669648 15302935
GSK3B AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 102.0 1.0 Omnipath 20128690 16944320 11738041 20043192 12511557 11967263 16890161 22613765 14663202 23602568 8524413 24451375 19303846 12554650 8638126 22509369 18593713 16199882 21988832 23331499 19759537 10428961 9482734 22270359 19202075 17570479 16293724 15327768 10581160 17318191 11487578 22773187 26496610 16568235 17318175 19131971 15465828 26912724 25241761 24976009 21242974 22682247 10228155 23579495 12584189 23959799 15020233 10421629 10488109 11278246 9501208 18632848 10481074 10535959 10318824 9554852 17601533 9832503 21502811 9734785 23455922
GSK3B APC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 16944320 11166179 16799642 11967263 14663202 8524413 12554650 8638126 17910481 15327768 10581160 11487578 17318175 15465828 10228155 15020233 10421629 10698523 9832503
GSK3B JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 23331499 1846781 25979842 25241761 20537194 21278055 21397588 17482134 1516134 8384355 17570479 16023596 17215518 30086763 92065884 24632621
GSK3B SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 18045539 25241761
GSK3B SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 18172167 21071413 21310903 23077590 28756206 19114991 19002158
GSK3B LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 22357953 23331499 19107203 21606194 16890161 21709260 16340998 16365045 19366350 21406690 16341017 17318175
GSK3B TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 24795562 12511557 23265840 15972957 16959574 22980037 22732551
GSK3B CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 183.0 1.0 Omnipath 22415718 11967263 27158593 29455668 19303846 19797085 8638126 19293931 23056571 22662165 25352148 16611981 27068260 28337019 10671551 21743491 20688898 16293724 23721711 23552738 18687691 28977889 19622173 12051714 25241761 27683053 28549350 22699938 19565571 23076981 21562161 19575820 20219694 20537194 10330181 21986938 29183346 27773936 11251183 19711366 21035499 19675674 7542250 23151663 24451375 14663202 23804296 8524413 25639486 23770025 18070361 26892600 30143633 9233789 19667122 27507058 19061640 19223551 29387014 23331499 16199882 11533658 18644116 24501426 24913829 11835406 17318191 26014148 25366337 28183999 22640743 26910375 12000790 12114015 18387957 19107203 9832503 16371461 29805709 27462866 20137080 27902311 12040186 19576224 25644994 12615961 19060929 25897075 12851486 15465828 17053159 18952601 10228155 15020233 17444818 20140245 26453498 17052453 16944320 24015932 23602568 24975844 24931005 28948000 20080742 23209942 30271168 28220106 16520547 28430641 11818547 25546293 27672271 11955436 11154277 26373837 16039586 23778311 28697793 20302655 25136145 26905812 22216350 8666229 12957350 23109003 10074433 28529629 20215423 21329734 11254732 9501208 27098453 27281614 30279527 19631635 25482131 18455992 24403311 11274345
DVL2 FZD7 â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 23821037 15936275 10698942 9716412 17130287 9674432 17627283 11358862 11101902 12015986 14636582
DVL2 FZD1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL2 WNT8B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL2 WNT8A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL2 WNT5A â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 23821037 15936275 10698942 9716412 17130287 9674432 17627283 11358862 11101902 12015986 14636582
DVL2 FZD2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL2 WNT3A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL2 LRP6 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL2 WNT1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL2 CSNK2A2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7744250 21285348 10698942 9192851 9214626
DVL2 CSNK1E â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 Reactome 12556519 21285348 11818547 11425858 10535959 16965538 10517632
DVL2 CSNK2A1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7744250 21285348 10698942 9192851 9214626
DVL2 CSNK2B â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7744250 21285348 10698942 9192851 9214626
FZD4 DVL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12958364 27096005 23331499
CSNK1D DVL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21316585 22609948 29426949 31579410
PLK1 DVL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20823832
CSNK1E DVL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 32888647 31515488 22609948 16189514 16713569 10517632
ARRB1 DVL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 11742073 16713569
DVL2 AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10329628 10829020 21245303 23892894 16713569 17529994
DVL2 RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 15262978 12533515
DVL2 LRRK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 20006983 19625296
GNB2 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19561403
GNB2 PLCB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 1465133 9307019 8387502 1465134 8306983
DVL3 FRAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12556519 23331499 10428961 9635432
AXIN1 FRAT1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 ACSN 10428961 16288291 16940750 19751508 22270359 8666229
DVL1 FRAT1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 ACSN 10428961 16288291 16940750 19751508 22270359 8666229
DVL1 FRAT1 â—¼   SHARES_COMPLEX 6.0 1.0 ACSN 10428961 16288291 16940750 19751508 22270359 8666229
AXIN1 FRAT1 â—¼   SHARES_COMPLEX 6.0 1.0 ACSN 10428961 16288291 16940750 19751508 22270359 8666229
DVL1 WNT3A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
AXIN1 WNT3A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
RYK WNT3A â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 20004982 15454084 22773843 21875946 16971168 16116452 16280981 19000841 16723543
WNT3A DVL3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
WNT3A FZD1 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 11448771 11029007 15459103 12205098 22000856 22653731 11357136 15084453 23256519 23791946
WNT3A CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 31.0 1.0 Omnipath 21108734 7641885 15265686 19718039 21602792 210606194 8655584 19705439 19029934 20093472 17430994 21606194 17884187 14747478 22017973 22433869 17143292 20006983 24535659 19072724 14704854 16965538 16443747 22007144 16547521 19020754 20940130 21640127 21087212 17127310 21796133
WNT3A RYK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 15454084 23331499 18988627
WNT3A LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 23400998 21078818 19339249 12897152 14739301 24265322 16890161 22726442 19910923 15578921 20093360 22491013 18772438 21944579
WNT3A FZD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18215320 19910923
WNT3A FZD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 21078818 10557084 11029007 10601008
WNT3A FZD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18215320
WNT3A FZD5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17117926 22753465 24032637
WNT3A FZD6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 21128903 21665003
WNT3A FZD8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22653731 20093360 22303445
FZD2 WNT8B â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 11448771 11029007 15459103 12205098 22000856 22653731 11357136 15084453 23256519 23791946
LRP6 WNT8B â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 11448771 11029007 15459103 12205098 22000856 22653731 11357136 15084453 23256519 23791946
DVL3 WNT8B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
AXIN1 WNT8B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
DVL1 WNT8B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
WNT8B FZD1 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 11448771 11029007 15459103 12205098 22000856 22653731 11357136 15084453 23256519 23791946
PLK1 ANAPC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19686080 19270156 18931676 19622404
ANKRD6 CSNK1E â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12183362
ANKRD6 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17032765
APC JUN â—¼   PHYSICAL_INTERACTION 33.0 1.0 ACSN 11274345 11955436 11967263 12051714 12711682 15001769 15327769 15834423 16039586 16510874 16547505 16940750 17143292 17439715 17936032 19216735 19506021 19619488 19623618 19751508 20006983 20705860 20964627 21285352 21681822 22270359 23343194 24023259 25730849 26587781 7542250 8545107 8666229
APC AXIN1 â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 10421629 10581160 11487578 11955436 11967263 12051714 12554650 15001769 15327768 16039586 16288291 16940750 17143292 17318175 17936032 19619488 19751508 20006983 20705860 22270359 23343194 24023259 25730849 7542250 8638126 8666229
APC JUN â—¼   SHARES_COMPLEX 33.0 1.0 ACSN 11274345 11955436 11967263 12051714 12711682 15001769 15327769 15834423 16039586 16510874 16547505 16940750 17143292 17439715 17936032 19216735 19506021 19619488 19623618 19751508 20006983 20705860 20964627 21285352 21681822 22270359 23343194 24023259 25730849 26587781 7542250 8545107 8666229
DAB2 APC â—¼   DOWN_REGULATES ✅ - 7.0 1.0 ACSN 15518237 17318175 19561074 19581931 20460648 21304492 21498506
AXIN1 APC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 16199882 20128690 19131971 11297546 9554852 22682247 10228155 26496610 23277359 10811618 9734785
CSNK1D APC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17910481 15327769 15747065 11487578
CSNK1E APC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 17145710 25241761 11425858 17570479 24722208 15327768 11487578 17218255
APC CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 60.0 1.0 Omnipath 17145710 10545404 11166179 8259519 7890674 22083140 27902311 8638126 16212417 16798748 19061640 9286858 15327769 9482734 11533658 22056988 19576224 15327768 17318191 26496610 12628243 15355978 9065403 11712088 25241761 26910375 22682247 9065401 12000790 11707392 20219694 9707618 23840886 15525529 11251183 8628279 19631635 11972058 21664290
ARRB1 GNAI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520
ARRB1 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 11742073 20223821
DVL1 AXIN1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
AXIN1 DVL1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 ACSN 10428961 16288291 16940750 19751508 22270359 8666229
AXIN1 WNT1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
AXIN1 FZD1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
AXIN1 FZD2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
AXIN1 WNT8A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
AXIN1 DVL1 â—¼   SHARES_COMPLEX 6.0 1.0 ACSN 10428961 16288291 16940750 19751508 22270359 8666229
LRP6 AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 20128690 23331499 8666229 12897152 10428961 24976009 16890161 18632848 22682247 23959799 16340998 18988627 19107203
DIXDC1 AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 15262978
LRP5 AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 8666229 11336703 10428961 18632848 21071413 19075000
PPP2R5D AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19131971 10026142 10995457 18042541 18559511 16680151
CSNK1A1 AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 11487578 11955436 11884395 12554650 8638126 19244247 15327768 10581160 10421629 12051714 17318175
CSNK1D AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21316585 12000790
CSNK1E AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 21988832 10535959 22682247 11884395 26496610 11487578 12000790
DVL1 AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 12556519 11278246 10862053 10330403 10330181 10428961 9482734 10196136 11027605 18339531
DAB2 AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 20460648 21498506 21304492 19561074 12805222 15518237 19581931 17318175
AXIN1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11438668 23331499 18988627
AXIN1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 52.0 1.0 Omnipath 20128690 20531388 16890161 27902311 22509369 18593713 16199882 23331499 9482734 21071413 26496610 19244247 22773187 17318191 10196136 18988627 17208333 19131971 24976009 22682247 10228155 12805222 12000790 10488109 9501208 9601641 18632848 9554852 19166851 23959799 12421363 9734785 11940574
BUB1 PLK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19228686 16760428
CCDC88C DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 14750955
CSNK1A1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 64.0 1.0 Omnipath 9312064 29495399 14966280 23531534 21764279 26227550 29793495 28220106 20561505 26862734 19293931 19623618 27558955 28430641 11818547 25546293 16199882 24648413 28337019 27672271 11955436 9482734 25915038 20419129 23778311 19244247 25500543 27768599 27488834 28183999 17208333 24594309 24038789 23076981 24904820 23690993 23744610 12000790 23687614 12114015 10488109 26604501 19711366 20699366 25517963 26189775 10023673 22025562
CSNK1A1 LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 25301071 23331499 21887268 16890161 27821587 14731402 24794231 25735981 20229235 16341017
CSNK1D YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 24715453 23431053
CSNK1D DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21316585 23331499 11818547
CSNK1D CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 10488109 9312064 23331499 11955436 9482734 14966280 10023673 12000790 11818547 12114015
DVL1 CSNK1E â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 Reactome 12556519 21285348 11818547 11425858 10535959 16965538 10517632
CSNK1E DVL3 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 Reactome 12556519 21285348 11818547 11425858 10535959 16965538 10517632
CSNK1E LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 16513652 20229235
CSNK1E YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 24715453 23431053
CSNK1E CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 46.0 1.0 Omnipath 9312064 7641885 15265686 19718039 21602792 14966280 210606194 8655584 19705439 11818547 19029934 20093472 17430994 21606194 17884187 11955436 9482734 14747478 17570479 12176352 22017973 22433869 17143292 20006983 19072724 14704854 16965538 16443747 22007144 12000790 12114015 16547521 10488109 19020754 20940130 12417018 21640127 21087212 17127310 21796133 10023673
CSNK1E DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 23331499 11425858 20006983 14966280 20215527 16965538 21285348 11487578 11818547
CSNK1G1 LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 17569865 23331499 19309792 19107203 26140605 18077588 24412065 21304492 16340998 18772438 16341016 16341017
DVL1 CSNK2A1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7744250 21285348 10698942 9192851 9214626
CSNK2A1 DVL3 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7744250 21285348 10698942 9192851 9214626
CSNK2A2 CSNK2A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 26186194 27705803 25519132 19011756 26496610 25852190 23455922
CSNK2A1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 12700239 12432063
CSNK2A1 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 10837139 20976471 10806215 25241761 20558317 10671551 17374729 21285348 11972058 21506126 11689703 10747897 16707567
CSNK2A1 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 26.0 1.0 Omnipath 25609649 1846781 11948398 15378002 12531896 19413330 8654373 15302935 11075956 12628923 11896587 1516134 8464713 11971971 1651323 8137421 9685505 91332050
DVL1 CSNK2A2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7744250 21285348 10698942 9192851 9214626
CSNK2A2 DVL3 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7744250 21285348 10698942 9192851 9214626
CSNK2A2 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12700239 19141652 12432063
DVL1 CSNK2B â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7744250 21285348 10698942 9192851 9214626
CSNK2B DVL3 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7744250 21285348 10698942 9192851 9214626
CSNK2B CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12432063
CTNNB1 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20300972 19671687 16007074 9990071
JUN CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17146436 18347071 16007074
DVL1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 25241761 10806215 20006983 15735151
WNT1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 21108734 7641885 15265686 19718039 21602792 210606194 8655584 19705439 19029934 20093472 17430994 21606194 17884187 14747478 16554443 18936100 22017973 22433869 17143292 20006983 19072724 14704854 16965538 16443747 22007144 16547521 19020754 20940130 21640127 21087212 17127310 15208637 21796133
LRP6 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 7641885 15265686 19718039 21602792 210606194 8655584 19705439 19029934 20093472 17430994 21606194 17884187 14747478 22017973 22433869 17143292 20006983 19072724 14704854 25088803 16965538 16443747 22007144 16547521 19020754 20940130 21640127 21087212 17127310 21796133
RAC1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 19751508 28626389 26403202 19417647 22270359 16212495 16940750 12480336 11152757 29497040 30650643 19020303 15377999
FZD1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 29.0 1.0 Omnipath 7641885 15265686 19718039 21602792 210606194 8655584 19705439 19029934 20093472 17430994 21606194 17884187 14747478 22017973 22433869 17143292 20006983 19072724 14704854 16965538 16443747 22007144 16547521 19020754 20940130 21640127 21087212 17127310 21796133
FZD5 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 29.0 1.0 Omnipath 7641885 15265686 19718039 21602792 210606194 8655584 19705439 19029934 20093472 17430994 21606194 17884187 14747478 22017973 22433869 17143292 20006983 19072724 14704854 16965538 16443747 22007144 16547521 19020754 20940130 21640127 21087212 17127310 21796133
CTNNB1 SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 15684397 21071413 18988627
CXXC4 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 18931698 11113207 15108311
CXXC5 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20220130 19643732
ROR2 DAAM1 â—¼   PHYSICAL_INTERACTION 54.0 1.0 ACSN 11226259 11698448 11729192 11739775 11779461 11992112 12194823 12361600 12740575 14657501 14704854 14744429 14747478 15265686 15279786 15618519 15761148 16713974 17127310 17303408 17517963 17660363 17884187 18037882 18256687 18423981 18497258 18590585 18851840 19020754 19366350 19565474 19836308 19853559 20006983 20351293 20535745 21178402 22017973 22949611 23732914 24857661 24919149 26885855 26885856 27048821 27066895 7479854 7575488 7641885 8655584 9362522 9660866 9822605
RHOA DAAM1 â—¼   PHYSICAL_INTERACTION 53.0 1.0 ACSN 11226259 11698448 11729192 11739775 11779461 11992112 12194823 12361600 12740575 14657501 14704854 14744429 14747478 15265686 15279786 15618519 15761148 16713974 17127310 17303408 17517963 17660363 17884187 18037882 18256687 18423981 18497258 18590585 18851840 19020754 19366350 19565474 19836308 19853559 20006983 20535745 21178402 22017973 22949611 23732914 24857661 24919149 26885855 26885856 27048821 27066895 7479854 7575488 7641885 8655584 9362522 9660866 9822605
ROR2 DAAM1 â—¼   SHARES_COMPLEX 54.0 1.0 ACSN 11226259 11698448 11729192 11739775 11779461 11992112 12194823 12361600 12740575 14657501 14704854 14744429 14747478 15265686 15279786 15618519 15761148 16713974 17127310 17303408 17517963 17660363 17884187 18037882 18256687 18423981 18497258 18590585 18851840 19020754 19366350 19565474 19836308 19853559 20006983 20351293 20535745 21178402 22017973 22949611 23732914 24857661 24919149 26885855 26885856 27048821 27066895 7479854 7575488 7641885 8655584 9362522 9660866 9822605
RHOA DAAM1 â—¼   SHARES_COMPLEX 53.0 1.0 ACSN 11226259 11698448 11729192 11739775 11779461 11992112 12194823 12361600 12740575 14657501 14704854 14744429 14747478 15265686 15279786 15618519 15761148 16713974 17127310 17303408 17517963 17660363 17884187 18037882 18256687 18423981 18497258 18590585 18851840 19020754 19366350 19565474 19836308 19853559 20006983 20535745 21178402 22017973 22949611 23732914 24857661 24919149 26885855 26885856 27048821 27066895 7479854 7575488 7641885 8655584 9362522 9660866 9822605
DVL1 DAAM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 11779461 19365405 20006983
DAAM1 RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11779461 25241761 18218625 20810787 19365405
DAB2 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 16713569 11387212
DAB2 DVL3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 20460648 23331499 21071413 21498506 21304492 16713569 19561074 12805222 15518237 19581931 17318175
DAB2 LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 20460648 21498506 21304492 19561074 22491013 15518237 19581931 17318175
DAB2 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16713569 11387212
PLK1 DCTN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 21931181 28415805 23985322 23661607 20679239
DIXDC1 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15262978 12526749 21189423
DVL1 LRP6 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL1 FZD1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL1 WNT1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL1 FZD2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL1 WNT8A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
GNAO1 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19705439 19561403
SDC4 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23151663 18403410 16604063
INVS DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 23331499 20798123 15852005 20006983
KLHL12 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16547521 20970343
HECW1 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 14684739 16713569
RYK DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15454084 23331499
SMAD1 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12650946 23331499 16621789
DVL1 LRRK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 20006983 19625296
DVL1 RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23331499 15608632 19365405 12533515 17363564
DVL1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 15888125 12650946 15955531
FZD2 DVL3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
WNT1 DVL3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
LRP6 DVL3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL3 WNT8A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL3 FZD1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
NKD1 DVL3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 23331499 20858476 19956716 15064403 11274398
FBXW7 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 14739463 28036276 18930588 16023596
FBXW7 NOTCH4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 15592418 11585921
FBXW7 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 26.0 1.0 Omnipath 11425854 11461910 20571051 23331499 20823234 17909182 25344755 32792479 11585921 16713569 17646408 27229929 15546612
WNT8A FZD1 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 11448771 11029007 15459103 12205098 22000856 22653731 11357136 15084453 23256519 23791946
WNT1 FZD1 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 10862746 20006983 17433286 23396967 15143170 15169958 21316585 16495441 20940229 23140633
LRP6 FZD1 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 11448771 11029007 15459103 12205098 22000856 22653731 11357136 15084453 23256519 23791946
WNT5A FZD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10557084
WNT1 FZD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10557084 22944199 15578921 16936075 24032637
LRP6 FZD2 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 11448771 11029007 15459103 12205098 22000856 22653731 11357136 15084453 23256519 23791946
WNT1 FZD2 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 11448771 11029007 15459103 12205098 22000856 22653731 11357136 15084453 23256519 23791946
FZD2 WNT8A â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 11448771 11029007 15459103 12205098 22000856 22653731 11357136 15084453 23256519 23791946
WNT5A FZD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 2808370 9389482 19008118 24032637 19910923
ROR2 FZD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12839624
WNT1 FZD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 14642436 15578921
WNT5A FZD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16273260 21903638 15578921 17804197 24032637
WNT5A FZD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 10990458 16602827
WNT5A FZD5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 11029007 9054360
ROR2 FZD5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12839624
WNT5A FZD6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16273260 21665003
FZD7 RAC1 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 19365405 18719708 11751577 12533515 9716412 11779461 9674432 23109420 15608632
FZD7 WNT1 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 10862746 20006983 17433286 23396967 15143170 15169958 21316585 16495441 20940229 23140633
WNT5A FZD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10990458
WNT1 FZD8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15454084 1545408415454080 11448771
RYK FZD8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15454084 17035295
WNT5A FZD8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 20093360 21518267
FZD8 LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11448771 21078818 11029007 20093360
FZD8 LRP5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11448771 21078818
WNT1 FZD9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 91476519147651 9147651
GNAQ PLCB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11753430 1309799 12193606 16754659 8245028 8387502 1322796 1846707
ITCH YAP1 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 10940313 11318614 16469705 16861923 18552861 18628966 21107885 21383157
ITCH NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 12682059 10940313 23331499 16713569
ITCH SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 21071413 19030025 15946939
SMAD3 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23331499 9732876 10220381 11306568 21829441 10903323
RB1 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10026157 9545246
JUN SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10220381 9312063 9732876
WNT1 LRP5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 21078818 11336703 15578921
LRP6 WNT8A â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 11448771 11029007 15459103 12205098 22000856 22653731 11357136 15084453 23256519 23791946
WNT5A LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 28143772 19056682 15578921 23462101 18606138
WNT1 LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 21078818 11029007 10557084 23331499 29444668 21071413 11448771 18988627
SMAD3 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 23331499 16713569 14638857 18988627
NOTCH1 POFUT1 â—¼   GLYCOSYLATION ✅ 5.0 1.0 Reactome 18347015 11524432 21464368 12486116 15692013
NOTCH2 POFUT1 â—¼   GLYCOSYLATION ✅ 5.0 1.0 Reactome 18347015 11524432 21464368 12486116 15692013
POFUT1 NOTCH3 â—¼   GLYCOSYLATION ✅ 5.0 1.0 Reactome 18347015 11524432 21464368 12486116 15692013
NOTCH4 POFUT1 â—¼   GLYCOSYLATION ✅ 5.0 1.0 Reactome 18347015 11524432 21464368 12486116 15692013
RAC1 PIP5K1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16212495 12480336 11152757 10679324 14681219
WNT5A RAC1 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 19365405 18719708 11751577 12533515 9716412 11779461 9674432 23109420 15608632
RAC1 ROR2 â—¼   PHYSICAL_INTERACTION 28.0 1.0 ACSN 11226259 11274345 11756498 12533515 14704854 14747478 15265686 15618519 17127310 17884187 18000759 18497258 18851840 18953287 19020754 19151919 19565474 19853559 20006983 20093472 20215527 21087212 21380625 21796133 22017973 27331412 7641885 8655584
RAC1 ROR2 â—¼   SHARES_COMPLEX 28.0 1.0 ACSN 11226259 11274345 11756498 12533515 14704854 14747478 15265686 15618519 17127310 17884187 18000759 18497258 18851840 18953287 19020754 19151919 19565474 19853559 20006983 20093472 20215527 21087212 21380625 21796133 22017973 27331412 7641885 8655584
ROR2 RHOA â—¼   PHYSICAL_INTERACTION 53.0 1.0 ACSN 11226259 11698448 11729192 11739775 11779461 11992112 12194823 12361600 12740575 14657501 14704854 14744429 14747478 15265686 15279786 15618519 15761148 16713974 17127310 17303408 17517963 17660363 17884187 18037882 18256687 18423981 18497258 18590585 18851840 19020754 19366350 19565474 19836308 19853559 20006983 20535745 21178402 22017973 22949611 23732914 24857661 24919149 26885855 26885856 27048821 27066895 7479854 7575488 7641885 8655584 9362522 9660866 9822605
ROR2 RHOA â—¼   SHARES_COMPLEX 53.0 1.0 ACSN 11226259 11698448 11729192 11739775 11779461 11992112 12194823 12361600 12740575 14657501 14704854 14744429 14747478 15265686 15279786 15618519 15761148 16713974 17127310 17303408 17517963 17660363 17884187 18037882 18256687 18423981 18497258 18590585 18851840 19020754 19366350 19565474 19836308 19853559 20006983 20535745 21178402 22017973 22949611 23732914 24857661 24919149 26885855 26885856 27048821 27066895 7479854 7575488 7641885 8655584 9362522 9660866 9822605
RHOA ROCK1 â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 11698448 11729192 11739775 11992112 12194823 12361600 12740575 14657501 14744429 15761148 17517963 18037882 18423981 20535745 21178402 22949611 24857661 24919149 26885855 27048821 27066895 7479854 9362522 9660866 9822605
RHOA ROCK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 55.0 1.0 Omnipath 17145710 12361600 25010901 23151663 7479854 27048821 22949611 21281639 26885855 8798490 12727213 17673200 11729192 8816443 10592173 11698448 27066895 11739775 11992112 20535745 18423981 24857661 21178402 23109003 9660866 9822605 17517963 14660612 15774750 12740575 14744429 9535835 12773565 15761148 24919149 26192618 9362522 18037882 14657501 12194823
WNT5A ROR2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 12839624 21316585 16602827 19530173 18215320
ROR2 VANGL2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 12839624 21316585 16602827 19530173 18215320
WNT5A ROR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 26690702 23331499 12839624 21069266 17203201 20215527 18606138
WNT1 RYK â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 20004982 15454084 22773843 21875946 16971168 16116452 16280981 19000841 16723543
RYK WNT5A â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20004982 22773843 16971168 16116452 16280981 23144463 16723543
RYK VANGL2 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20004982 22773843 16971168 16116452 16280981 23144463 16723543
WNT5A RYK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15598975 22773843
WNT1 RYK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 15454084 23331499 1545408415454080
SIRT1 SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21071413 23331499 17098745
YAP1 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19914168 35044719 23431053 21685363
SMAD1 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 34.0 1.0 Omnipath 17183365 9436979 24412244 11779505 31467278 21454478 10531362 15231748 12167862 23331499 21071413 11700304 12874272 16189514 18988627 20957627 9111321 15761153 32296183 26555259 14701756 14534577
SMAD3 SMAD2 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10454538 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23869868 8515656 9312026 9389648 9618481 9670020 9865696
SMAD4 SMAD2 â—¼   PHYSICAL_INTERACTION 52.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11399519 11792802 11875494 12193690 12545156 12702545 12809600 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 17055429 17260466 17550342 17689680 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23390297 23784029 23869868 6357187 8515656 8871614 9312026 9389648 9618481 9670020
SMAD2 SMAD7 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 11074002 11279127 15265520 16179589 16713975 21042762 21614932 22331441 23784029 9670020
SMAD2 SMAD7 â—¼   DOWN_REGULATES ✅ - 10.0 1.0 ACSN 11074002 11279127 15265520 16179589 16713975 21042762 21614932 22331441 23784029 9670020
SMAD2 SMAD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16052471 11376804 11456453 9812998
SMAD2 SMAD7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15183844 10887185 10753944 10843994 10559222
SMAD7 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 17438144 21071413 9892009 9892110
WWP1 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 15221015 15946939 15359284
SMAD2 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 110.0 1.0 Omnipath 15613484 17145710 25609649 15817471 20211142 21532621 24584437 18729074 23788427 12419246 16916642 9288972 9892009 21454478 17510063 10531362 15231748 11027280 12167862 21988832 9389648 23331499 12543979 18568018 21071413 19135894 18511908 15467747 12808092 11927552 25514493 15350224 18988627 12732634 10878024 9111321 9311995 9346908 10199400 11264182 12957874 11114293 15761153 11274206 12621041 17272273 24157709 26555259 12374795 22442258 10781087 15922743 11102446 17591701 18783722 16751102 19139564 19917253 9346966 21297662 17283070 12794086
SMAD2 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 21988832 26186194 12543979 9111321 15084259 9311995 25878769 18729074 12700238
SMAD4 SMAD3 â—¼   PHYSICAL_INTERACTION 72.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013125 11013220 11074002 11114293 11224571 11279127 11283613 11283614 11376132 11399519 11792802 11875494 12193690 12545156 12702545 12809600 14976548 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 16831886 17018611 17055429 17260466 17550342 17563753 17689680 17705132 18353785 18768831 18832382 19208835 19597490 19815509 19901969 20027199 20713526 20731704 21041997 21042762 21098712 21252118 21317430 21577210 21614932 2191300 22331441 22514743 22652804 23140366 23338822 23390297 23784029 23869868 25374926 6357187 8515656 8871614 8893010 9312026 9389648 9618481 9670020
SMAD3 SMAD7 â—¼   PHYSICAL_INTERACTION 13.0 1.0 ACSN 11279127 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21614932 22331441 23784029 8515656
SMAD3 SMAD7 â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 11279127 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21614932 22331441 23784029 8515656
SMAD4 SMAD3 â—¼   LOCALISATION ✅ 72.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013125 11013220 11074002 11114293 11224571 11279127 11283613 11283614 11376132 11399519 11792802 11875494 12193690 12545156 12702545 12809600 14976548 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 16831886 17018611 17055429 17260466 17550342 17563753 17689680 17705132 18353785 18768831 18832382 19208835 19597490 19815509 19901969 20027199 20713526 20731704 21041997 21042762 21098712 21252118 21317430 21577210 21614932 2191300 22331441 22514743 22652804 23140366 23338822 23390297 23784029 23869868 25374926 6357187 8515656 8871614 8893010 9312026 9389648 9618481 9670020
SMAD3 SMAD7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 10823886 15183844 12761881 10887185 10973944 10839991 10753944 10843994 15579469 10559222
SMAD7 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 21071413 9892009 26555259 9892110
SMAD3 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 104.0 1.0 Omnipath 25609649 9843571 15084259 20211142 21532621 24584437 18729074 23788427 12419246 18923419 9892009 19768112 10531362 15231748 9679060 12167862 21988832 12150994 23331499 12543979 18568018 21071413 19135894 15467747 25502805 9732876 11927552 16189514 12917407 25514493 15350224 10995777 18988627 10092624 12732634 25910212 10878024 9111321 20564330 27107012 9311995 12957874 20142324 11114293 32296183 15588252 15761153 24157709 26555259 29892012 17469184 22442258 16714330 21597466 15922743 22045334 17591701 24382352 22310290 19139564 19917253 29997244 31515488 28115363 10942775 21297662 17283070 12794086
SMAD4 SMAD7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 10823886 15183844 10887185 19032343 10839991 16442497 10753944 10843994 15128733 10559222
YAP1 SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 22921829 12118366 25283809
WWP1 SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 15221015
WNT5A VANGL2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 12839624 21316585 16602827 19530173 18215320
YAP1 WWTR1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 12807903 18280240 18617895 21666501 23708000 25502501 26711338 7782338
MSH2 MSH2 â—¼   KO_DOWN_REGULATES ✅ - -6.48 6.47 PKG 28854368