Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
GLI3 GSK3B â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 16371461 16705181
CSNK1A1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19293931 22083140
GSK3B SMO â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15803137 23331499
GSK3B GLI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16481469 23331499
SMO TIAM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20654717 23074268
GNAI1 GNG2 â—¼   PROXIMITY 2.0 0.8 intact 8189321 21552208
SMO GNG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23074268 16885213
SMO GNB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23074268 16885213
SMO C4ORF3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
PTCH1 GRK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19502428 0812105106
GRK2 PTCH1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19502428 0812105106
SMO ARV1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
SMO PLPP7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
FYN AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PRKACA AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
BCL6 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22422878 19487462
SRC ARRB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16432186 0510562103
SMO ARRB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15618519 23074268
ARRB1 SMO â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 15618519
ARRB2 KIF3A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23074268 16908539
SMO C18ORF32 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
GLI2 CSNK1A1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17283082 16611981
CSNK1A1 SUFU â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17283082 16611981
CSNK1E SMO â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 20708941
SMO EMC10 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
SMO FKBP8 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
SP1 FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
FYN GABBR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
FYN HMOX2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SMO FYN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18455992 23074268
FYN NGEF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15848799 11336673
SMO GABARAPL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
SMO GABBR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
SP1 GATA3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15486968
SMAD3 GATA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 11790301
SMAD3 GLI2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19797115
KIF7 GLI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19549984
GLI3 PTCH2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14691458
KIF7 GLI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19549984 19592253
SMO GNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23074268 16885213
GNB1 GNAI2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7102203 16782902
SMO GNAI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23074268 16885213
SMO GNAI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23074268 16885213
GNAT1 GNGT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16895762 6264430
SMO GNAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23074268 16885213
SMO GNAT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23074268 16885213
SMO GNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23074268 16885213
SMO GNG3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23074268 16885213
GRK6 SMO â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 15618519
SMO HMGN4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
SMO HMOX1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
SMO HMOX2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
SP1 ILK â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19176380 24361375
SMO ITGB1BP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
SMO JPH3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
JPH3 SMAD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SMO LEPROT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
NCOA2 SRC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19305643 10454563
NCOA2 PRKACA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11923473 23936147
SMO NDFIP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
SMO NGEF â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
SRC NGEF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15848799 11336673
SMO NIPA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
PRKACA SMAD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SMAD3 RANBP9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMO RPN2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
SMO S1PR5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
SP1 SGK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9415398 10614661
SMO SSPN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
SMO TMCC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
SMO WLS â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
SMO TSPAN7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
SMO TIMMDC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
SRC SP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
NEDD4 AKT1 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 19953087 23195959 31390487
KIF3A KIF3B â—¼   CORRELATES + 0.81 0.81 CCLE 31978347
GNAI3 GNB2 â—¼   PHYSICAL_INTERACTION 819.0 0.81 STRING 36370105
GLI2 KIF7 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 35140242
GLI2 SUFU â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
AKT1 GSK3B â—¼   DOWN_REGULATES ✅ - 0.82 0.82 Signor 15829723
AKT1 GSK3B â—¼   PHOSPHORYLATION ✅ - 0.82 0.82 Signor 23552696
GLI2 STK36 â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
GNAI1 GNGT1 â—¼   PHYSICAL_INTERACTION 834.0 0.83 STRING 36370105
PTCH2 SMO â—¼   PHYSICAL_INTERACTION 839.0 0.83 STRING 36370105
ARRB2 SRC â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
DVL1 SMAD3 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 12650946
ARRB2 NEDD4 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 18544533 23208550
FYN MAG â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 16713569 7525550
SMAD3 NEDD4 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 19953087 15496141 21685363 32296183
GNAI1 GNAI2 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
ADRBK1 GNG2 â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
STK36 GLI1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 25241761 10806483
STK36 GLI3 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 25241761 10806483
GNAI1 GNAI3 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
GNAI2 GNG2 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
GSK3B SMAD3 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 21310903 18172167
SMO PTC1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11278759 9811851
ILK AKT1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11825911 11546794 11313365 18339839 11278835 12149249 14500673 9736715 12176337 11445557 16189514
SUFU GLI3 â—¼   RELOCALIZATION ✅ - 0.88 0.88 Signor 10564661
GNAI2 GNAI3 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
PTCH1 SMO â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
SRC FYN â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 16966330 31980649 28514442 19711372 9169421
SUFU GLI2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 35140242 12068298 10564661
GNAI3 GNAT2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 28514442 26186194
SGK1 NEDD4 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 20730100 19953087 11696533 12729930
SP1 SMAD3 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10878024 11114293 22227581 12228247 11432852 16714330
GSK3B GNB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
FYN GSK3B â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 17607942 15676027 15652488
DVL1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10428961 16914735 20837657
SMO GNB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23074268 17251915 16885213
GNB2 GRK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 1325672 8416978 1962211
AKT1 SMAD3 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 25241761 16362038
ARRB2 ARRB1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 17353931 24069330 28514442 17620599
SP1 CXCL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11115149 7479086 11112786
PRKACA FYN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20658524
SUFU GLI1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 20211142 32296183 21543335 25241761 31278361 10564661 25609649 10559945 29662197 24217340 12068298 22439934 24854174 29249966 12426310 24311597 16189514 27234298
GLI1 SHH â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19384336 16855373 9247260
GLI2 PRKACA â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 17283082 19056373 16611981
SUFU GLI2 â—¼   RELOCALIZATION ✅ - 0.9 0.9 Signor 16316410
SUFU GLI3 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 29515120 24311597 35140242 10564661
S1PR5 GNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11069896 16189514 31160049
RAB23 KIF3A â—¼   REGULATES ✅ 3.0 0.9 ACSN 11449277 18497258 20375059
RAB23 KIF3B â—¼   REGULATES ✅ 3.0 0.9 ACSN 11449277 18497258 20375059
MAP3K7 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9380693
RAB23 SMO â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11449277 20375059 18497258
RAB23 SMO â—¼   REGULATES ✅ 3.0 0.9 ACSN 11449277 18497258 20375059
SP1 SRC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10625617 19112177
GLI3 STK36 â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
GLI1 STK36 â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
GNB3 GNGT1 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
GNB2 GNGT1 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
GNAI1 SMO â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
AKT1 GSK3B â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
GNB1 SMO â—¼   PHYSICAL_INTERACTION 936.0 0.93 STRING 36370105
SHH PTCH1 â—¼   PHYSICAL_INTERACTION ✅ - 0.93 0.93 Signor 15618519
SMO STK36 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
GNG2 SMO â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
ADRBK1 GNB1 â—¼   PHYSICAL_INTERACTION 953.0 0.95 STRING 36370105
GLI3 SUFU â—¼   PHYSICAL_INTERACTION 959.0 0.95 STRING 36370105
PTC1 SHH â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 31253779 30139912 9811851 29954986 16282375 19561609
FYN SRC â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
STK36 SUFU â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
GNAI1 GNG2 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
GNAI2 GNB1 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
GNAI3 GNB1 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
PTCH1 SHH â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
GNB3 GNG3 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB3 GNG12 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB2 GNG3 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB2 GNG12 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB1 GNG12 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB1 GNG3 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB2 GNG2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GNB3 GNG2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GNAI1 GNB1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GNB1 GNGT1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GNB1 GNG2 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
DVL1 GSK3B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
AKT1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 99.0 1.0 Omnipath 17428466 15207235 17145710 12052830 10729337 8250835 11756412 11923280 16914735 17623045 16697215 8524413 12054501 20398329 18372248 21506126 20028971 12040186 15808505 16543730 20138985 23331499 21303971 16009706 10385618 20214616 23180781 9373175 16039586 15829723 18988627 16282323 11577096 11035810 18669648 18216173 15169778 12851486 16123141 11882383 23109003 9065430 18691976 22094462 10949026 22710759 11715018 12459251 18636226 17192257 11254732 11278246 20858269 9812896 9582355 15023346 17680028 19369195 7945242 12900420 23552696 18387957 10722653 20832730 18570873 12147701 18505846 17052453 17693255 18218901
ILK GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 15207235 14990992 16799642 20827300 27683053 9736715 12960424 26547035 17490631 12629168 17182785 21035499 16189514 17107957 16936772 17485554
PRKACA GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 16543730 15845746 18691976 19836308 8524413 12054501 16039586 12147701 16522636 11035810 18669648
GSK3B GLI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 17444818 16611981 20537194 10671551 20080742 19797085 16039586 19575820 12040186 17052453 12615961 18455992 16371461 11274345
GSK3B SUFU â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 17444818 27234298 16611981 20537194 10671551 20080742 19797085 16039586 19575820 21317289 12040186 17052453 12615961 18455992 16371461 11274345
GSK3B GLI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 16705181 20080742 19797085 12040186 23331499 16611981 10671551 16039586 12615961 16481469 19575820 11955435 17444818 20537194 16885213 19622347 17052453 18455992 16371461 11274345
GSK3B SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 18172167 21071413 21310903 23077590 28756206 19114991 19002158
SRC TIAM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12810717 19285946
SMO MIR378 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 17641202 18820483 19081070 19351822 20215540 20564213 23031257
GNB1 GNG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23739333 8636150 9789084 10339615 12606627 15889144 15782186 11294873 18611381 10696571 19376773 12782285 19168127
GNG2 GNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23739333 8636150 9789084 10339615 12606627 15889144 15782186 11294873 18611381 10696571 19376773 12782285 19168127
GNB2 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19561403
GRK2 SMO â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 14636583 16908539 16630821 15691767 20844016 24925320 18815277 24845016 21695114 17960137 23719536 14614827
GRK2 CSNK1A1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 14636583 16908539 16630821 15691767 20844016 24925320 18815277 24845016 21695114 17960137 23719536 14614827
PRKACA GRK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11278469
SRC GRK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12624098 16725308 11278940 11566877 16189514
GRK2 SMO â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21695114 15618519 23074268
SP1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19145069 15342781 21520171 18353772
ILK AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 11546794 14500673 12176337 11445557 15899889 23840605 9736715 12149249 10592173 11313365 16189514 19460343 11278835 15212693 18772455 10226025 11825911
SRC AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 11445557 25241761 23242524 18283331 12600984
SMO AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 20016067 20643644 20956384 21209912 18820483 17641202 17688959 18997815 19549984 19592253 16537363
AKT1 PRKACA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 20016067 23331499 17680028 20214616 17688959 20398329 16537363 17052453 19575820
AKT1 HMOX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15581622
AKT1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 25241761 15104092 16362038 21071413 18988627 26297431 15048128
AKT1 GATA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 27053161 15837948
SRC ARRB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 17456469 17456551 16432186
ARRB1 GNAI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520
ARRB1 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 11742073 20223821
ARRB1 GNAI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520
ARRB1 GNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520
SMO ARRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15618519 23074268
ARRB2 GNAI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520
ARRB2 GNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520
ARRB2 GNAI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520
SHH CP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9811851 15618519 17419683 14556242
GLI3 CSNK1A1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 16371461 20154143 21921029 16705181
CSNK1A1 GLI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 21233202 7641885 16611981 21536646 19797085 18455992 16371461 11955435
CSNK1A1 GLI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 21233202 7641885 16611981 17419683 21536646 19797085 18455992 16371461
DVL1 CSNK1E â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 Reactome 12556519 21285348 11818547 11425858 10535959 16965538 10517632
CSNK1E GLI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21233202 7641885 16611981 21536646 19797085 18455992 16371461
CSNK1E DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 23331499 11425858 20006983 14966280 20215527 16965538 21285348 11487578 11818547
CSNK1E GLI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 21233202 7641885 16611981 21536646 19797085 18455992 16371461
GNAO1 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19705439 19561403
DVL1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 15888125 12650946 15955531
EVC SMO â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 21356043 22986504 23026747 24582806 22981989
EVC2 SMO â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 21356043 22986504 23026747 24582806 22981989
FYN MAG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16713569 7525550
GLI1 SUFU â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 10559945 11001584 11960000 17638910 18754008 19055941 19081070 19684112 22354771 23031257
GLI1 SUFU â—¼   SHARES_COMPLEX 10.0 1.0 ACSN 10559945 11001584 11960000 17638910 18754008 19055941 19081070 19684112 22354771 23031257
SMO GLI1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 17641202 18820483 19081070 20215540 23031257
SMAD3 GLI1 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 8515656 9389648
GLI1 PRKACA â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 17283082 16421275 19056373 16705181
GLI1 ULK3 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 Reactome 20643644 22391301 18827223 12138125 12050670 19878745 18455992
GLI1 PTCH1 â—¼   ENZYMATIC_REACTION ✅ 27.0 1.0 ACSN 11001584 11960000 12138125 14555646 15087129 15520176 16054035 16158046 16328026 16396903 16406505 16571352 16880536 17000779 17035233 17638910 18754008 18813803 19081070 19190345 19219074 19736394 20107231 21059263 21442356 22354771 23031257
GLI3 GLI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12435627 14723851 10075717 16571352 19667090
GLI2 GLI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16571352 15175043 12165851 9636069
GLI1 PTCH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19860666 21076395 11719506 16571352 15087129
GLI2 GLI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 18813803 16880536 19190345 18698484 15087129 17845852 19049965 11001584 20107231 20712011 15520176 16406505 17000779 16413481 16571352 16396903 9609833 18497536 14555646 9216996 20581804 11493558 15140221 16054035 20143239
SUFU GLI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 25609649 19055941 20211142 10559945 11960000 24854174 15367681 23331499 27234298 24311597 21071413 12426310 16189514 18988627 24217340 25241761 32296183 10564661 22439934 21543335
PRKACA GLI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16481469 23331499 20027184 16293631 19996099
STK36 GLI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 17145710 10806483 25241761
GLI1 PTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 16158046 18813803 19219074 16880536 21059263 11960000 19190345 15087129 21442356 16328026 19736394 11001584 12138125 20107231 15520176 16406505 17000779 16571352 16396903 14555646 17035233 16054035
GLI1 PTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 16158046 18813803 19219074 16880536 21059263 11960000 19190345 15087129 21442356 16328026 19736394 11001584 12138125 20107231 15520176 16406505 17000779 16571352 16396903 14555646 17035233 16054035
SMAD3 GLI2 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 8515656 9389648
SMO GLI2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 17641202 18820483 19081070 20215540 23031257
GLI2 ULK3 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 Reactome 20643644 22391301 18827223 12138125 12050670 19878745 18455992
GLI2 PTCH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 14691458 9636069 16571352 15087129 19574535
STK36 GLI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10806483
KIF3A GLI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14603322 20643644 20956384 11208056
PRKACA GLI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 16611981 20027184 16885213 17419683 19056373 19996099
GLI3 GLI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 21234400 20562908 9216996 19032343 12435627 16406505 19114989 16880536 16054035 11001584 17000779 16169709 16413481 15087129 16396903 19809516 20107231
SMO GLI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 20016067 20643644 20956384 21209912 18820483 17641202 17688959 18997815 19549984 19592253
SUFU GLI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 20463034 10564661 35044719 16316410
GLI2 PTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 18813803 16880536 19190345 18698484 15087129 17845852 19049965 11001584 20107231 20712011 15520176 16406505 17000779 16413481 16571352 16396903 9609833 18497536 14555646 9216996 11493558 15140221 16054035 20143239
GLI2 PTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 18813803 16880536 19190345 18698484 15087129 17845852 19049965 11001584 20107231 20712011 15520176 16406505 17000779 16413481 16571352 16396903 9609833 18497536 14555646 9216996 11493558 15140221 16054035 20143239
GLI3 ULK3 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 Reactome 20643644 22391301 18827223 12138125 12050670 19878745 18455992
GLI3 PRKACA â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17283082 16705181 20154143 16371461 16611981
SMO GLI3 â—¼   DOWN_REGULATES ✅ - 5.0 1.0 ACSN 17641202 18820483 19081070 20215540 23031257
GLI3 PTCH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 19860666 17419683 28533268 24276242 10077605 16571352 15087129
PRKACA GLI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 16481469 23331499 20027184 17419683 10693759 19996099
SUFU GLI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 17145710 23331499 24311597 20463034 10433919 20083481 10564661
KIF3A GLI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 14603322 20643644 20956384 11208056
SMO GLI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 20016067 20643644 20956384 21209912 18820483 17641202 17688959 18997815 19549984 19592253
GLI3 PTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 21234400 20562908 9216996 19032343 12435627 16406505 19114989 16880536 16054035 11001584 17000779 16169709 16413481 15087129 16396903 19809516 20107231
GLI3 PTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 21234400 20562908 9216996 19032343 12435627 16406505 19114989 16880536 16054035 11001584 17000779 16169709 16413481 15087129 16396903 19809516 20107231
GNAI1 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23109003 11007482 10753828 9722546
GNAI2 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23109003 11007482 11160627 10753828 9722546
GNGT1 GNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 25675501 8636150 9789084 10360181 12782285 19168127
IHH PTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23331499 29274272 9811851
IHH PTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 23331499 115627869811851 19399989 20083481 29274272 11562786 9811851
SMO KIF3A â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 11208056 11226259 11449277 14603322 15618519 17641202 18497258 18820483 19081070 19565474 19853559 20215540 20375059 23031257
KIF3A KIF3B â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11208056 11226259 11449277 14603322 15618519 15852005 17641202 18497258 18820483 19081070 19565474 19718039 19853559 20215540 20375059 20643644 20956384 21602792 23031257
SMO KIF3A â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 11208056 11226259 11449277 14603322 15618519 17641202 18497258 18820483 19081070 19565474 19853559 20215540 20375059 23031257
KIF3A SUFU â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 11208056 14603322 20643644 20956384
KIF3A KIF7 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 11208056 14603322 20643644 20956384
KIF3A ULK3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 11208056 14603322 20643644 20956384
SMO KIF3B â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 11208056 11226259 11449277 14603322 15618519 17641202 18497258 18820483 19081070 19565474 19853559 20215540 20375059 23031257
SMO KIF3B â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 11208056 11226259 11449277 14603322 15618519 17641202 18497258 18820483 19081070 19565474 19853559 20215540 20375059 23031257
KIF3B KIF7 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 11208056 14603322 20643644 20956384
KIF3B SUFU â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 11208056 14603322 20643644 20956384
KIF3B ULK3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 11208056 14603322 20643644 20956384
SUFU KIF7 â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 0643644 11001584 17845852 18497536 19055941 19549984 19592253 19666503 19684112 19878745 19906571 20643644 20956384 21209912
ULK3 KIF7 â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 0643644 11001584 17845852 18497536 19055941 19549984 19592253 19666503 19684112 19878745 19906571 20643644 20956384 21209912
SUFU KIF7 â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 0643644 11001584 17845852 18497536 19055941 19549984 19592253 19666503 19684112 19878745 19906571 20643644 20956384 21209912
ULK3 KIF7 â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 0643644 11001584 17845852 18497536 19055941 19549984 19592253 19666503 19684112 19878745 19906571 20643644 20956384 21209912
SMO KIF7 â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 17641202 17688959 18820483 18997815 19081070 19549984 19592253 20016067 20215540 20643644 20956384 21209912 23031257
SMO KIF7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 20016067 20643644 20956384 19666503 21209912 18820483 17641202 17688959 18997815 19549984 19592253
NDFIP1 NEDD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11042109 11748237 26363003 27173227
PRKACA SUFU â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 17283082 16421275 19056373 16705181
SP1 PRKACA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12759366 16574895 16790435 9458366 9415398 12169688 10949931 12694408 11562358
SMO PRKACA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 20016067 23331499 20643644 20956384 21209912 18820483 17641202 17688959 18997815 19549984 19592253 14611647
PRKACA SUFU â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23331499 27234298 16611981 20027184 21209912 29371981 23337587 21317289 14611647
PRKACA SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 19651622 17081983 20166139 2474754 18088087 15546918 19664994 11804588
SHH PTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 16282375 29995851 15618519 23331499 30613383 21339334 30139912 14556242 27647915 20083481 16867986 9811851 8906787 29954986
PTCH1 SMO â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 23331499 12192414 14556242 20207148 16867986 9811851 8906787 20076617
SHH PTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 9811851
PTCH2 SMO â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9811851 23331499 18988627
SHH SMO â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 18754008 20495383 22354771 24856585
SHH SMO â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16867986 8906787
SMAD3 SP1 â—¼   PHYSICAL_INTERACTION 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
SMAD3 SP1 â—¼   SHARES_COMPLEX 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
SMAD3 SP1 â—¼   ENZYMATIC_REACTION ✅ 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
SMO SUFU â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 17641202 17688959 18820483 18997815 19081070 19549984 19592253 20016067 20215540 20643644 20956384 21209912 23031257
SMO ULK3 â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 17641202 17688959 18820483 18997815 19081070 19549984 19592253 20016067 20215540 20643644 20956384 21209912 23031257
SMO SUFU â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 20016067 20643644 20956384 22114142 21209912 18820483 17641202 17688959 18997815 19549984 19592253
SUFU STK36 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 17145710 23331499 25241761 10072378 10806483
SUFU ULK3 â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 0643644 11001584 16371461 16611981 16651270 17845852 18455992 18497536 18813803 19055941 19549984 19592253 19666503 19684112 19878745 19906571 20643644 20956384 21209912
SUFU ULK3 â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 0643644 11001584 16371461 16611981 16651270 17845852 18455992 18497536 18813803 19055941 19549984 19592253 19666503 19684112 19878745 19906571 20643644 20956384 21209912
SUFU ULK3 â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 0643644 11001584 16371461 16611981 16651270 17845852 18455992 18497536 18813803 19055941 19549984 19592253 19666503 19684112 19878745 19906571 20643644 20956384 21209912