Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
GNB1 RAMP1 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
GNG2 RAMP1 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
GNAS RAMP1 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
GNAS RAMP2 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
GNG2 RAMP2 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
GNB1 RAMP2 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
ADM2 RAMP3 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
GNB1 RAMP3 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
GNG2 RAMP3 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
GNAS RAMP3 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
ADM RAMP3 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
AR RACK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17108144 12958311
GNA14 PLCB3 â—¼   PHOSPHOLIPASE ✅ 2.0 0.8 Reactome 11015615 2841328
GNA11 PLCB3 â—¼   PHOSPHOLIPASE ✅ 2.0 0.8 Reactome 11015615 2841328
GNA15 PLCB3 â—¼   PHOSPHOLIPASE ✅ 2.0 0.8 Reactome 11015615 2841328
PLCB2 PLCB3 â—¼   PHOSPHOLIPASE ✅ 2.0 0.8 Reactome 11015615 2841328
GNAQ PLCB3 â—¼   PHOSPHOLIPASE ✅ 2.0 0.8 Reactome 11015615 2841328
PLCB3 PLCB1 â—¼   PHOSPHOLIPASE ✅ 2.0 0.8 Reactome 11015615 2841328
PLCB3 PLCB4 â—¼   PHOSPHOLIPASE ✅ 2.0 0.8 Reactome 11015615 2841328
GNG2 GPR52 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
GLP1R ARRB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18445652 0710402105
SRC PXN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15574420 14665621
PXN PTPN11 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 15574420 14665621
PIK3R1 PXN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23397142 25241761
FGR PXN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9636140 23109003
LYN PXN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9636140 23109003
PXN PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23397142 25241761
CXCL8 GNG2 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
CXCL8 GNB1 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
CXCL8 GNAI1 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
MYC CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21925595 23722468
ADM2 GNG2 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
GCG GNG2 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
CXCR2 GNG2 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
FPR2 GNG2 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
ADORA1 GNG2 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
ADM GNG2 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
CCL20 GNG2 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
CNR1 GNG2 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
CNR2 GNG2 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
GNG2 P2RY12 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11196645 8554519
GNG2 SCT â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
GNG2 PREX1 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
GNG2 TRPM3 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
GNAI1 GNG2 â—¼   PROXIMITY 2.0 0.8 intact 8189321 21552208
SMO GNG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23074268 16885213
GNG2 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17419683 16537363
GNA14 GNB3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25675501 15889144
GNB3 GNAQ â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25675501 15889144
GNB3 GNA11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25675501 15889144
GNB3 GNA15 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25675501 15889144
GNA14 GNB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25675501 15889144
GNAQ GNB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25675501 15889144
GNA15 GNB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25675501 15889144
GNA11 GNB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25675501 15889144
SMO GNB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23074268 16885213
CNR1 GNB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15082510 2165569
GNB2 ADCY2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1962211 1312225
GNB2 KCNJ3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8145826 2433589
GNB1 SCT â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
GNAS SCT â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
GNA14 PDCL â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25675501 15889144
GNA14 PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16268778 18515384
GNA14 GNB4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25675501 15889144
GNA14 PIK3R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16268778 18515384
GNA14 GNA11 â—¼   GTPASE_REACTION ✅ 2.0 0.8 Reactome 8073283 7937899
GNA14 GNAQ â—¼   GTPASE_REACTION ✅ 2.0 0.8 Reactome 8073283 7937899
GNA14 GNA15 â—¼   GTPASE_REACTION ✅ 2.0 0.8 Reactome 8073283 7937899
ADRB2 GNA14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7797501 31160049
GNA14 PLCB1 â—¼   PHOSPHOLIPASE ✅ 2.0 0.8 Reactome 11015615 2841328
GNA14 PLCB4 â—¼   PHOSPHOLIPASE ✅ 2.0 0.8 Reactome 11015615 2841328
GNA14 PLCB2 â—¼   PHOSPHOLIPASE ✅ 2.0 0.8 Reactome 11015615 2841328
GRK2 TBXA2R â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16956790 10085139
ADM GNB1 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
ADM GNAS â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
AR ADM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16376459 20610535
MYC ADM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9973255 15192039
ADM2 CALCRL â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
ADM2 GNB1 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
ADM2 GNAS â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
AR ADORA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20610535 16987234
ADRA1A GNAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 31160049 1334487
ADRA1B GNAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9481484 31160049
AR ADRA1D â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20610535 16964290
ADRA2A GNAI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 31160049 1849000
ADRA2A GNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 31160049 11732925
ADRA2C GNAO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1349607 31160049
ADRB2 KCNJ6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
AR ADRB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9855630 20610535
SRC ADRB2 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5219452 17170700
ADRB2 ARRB2 â—¼   COLOCALIZATION 2.0 0.8 intact 23208550 8428323
ARRB1 ADRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16407241 11171997
AR POMC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18703637 15375188
AR PIK3CB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23365759 20610535
AR ESR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11371645 20610535
AR F2R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20610535 15629896
AR TBXA2R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15820970 15769993
AR PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12933816
AR F2R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15629896
ARHGEF6 RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10592173 16492808
SRC ARRB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16432186 0510562103
PTH1R ARRB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16189514 12220636
SMO ARRB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15618519 23074268
ARRB1 SMO â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 15618519
ARRB1 GNAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23353685
PTK2 BCAR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5221628 9285683
YES1 BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 32296183 35044719
BCAR1 DOCK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12615911
BCAR1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 27447856 10799562
GNA12 BTK â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11742120 9796816
CALCA CALCR â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 6148938 1331173
CCL20 GNB1 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
PIK3R2 CD247 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12869549 15536084
CD247 CD3G â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
CD247 PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12869549 15536084
CD247 PIK3CB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12869549 15536084
CD3G CD247 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
HLA-DRA CD247 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD3E CD247 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD3D CD247 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
HLA-DRA CD3D â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD4 CD3D â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD3D CD3G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD3D LCK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD3D CD3E â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
LCK CD3E â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD4 CD3E â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
HLA-DRA CD3E â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD3E CD3G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
PIK3R2 CD3G â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12869549 15536084
CD3G PIK3CB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12869549 15536084
CD3G PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12869549 15536084
CD4 CD3G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
LCK CD3G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
HLA-DRA CD3G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD4 HLA-DRA â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
CD4 HLA-DRA â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD4 LCK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
MYC CD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1321339 11266125
FYN CDC42 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11817894 15788770
SRC CDC42 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11817894 15788770
CDC42 PTK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11817894 15788770
CDC42 PAK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11278486 11804587
CNR1 GNAO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15082510 31160049
CNR1 GNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11168387 31160049
CNR2 GNAI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15082510 31160049
CNR2 GNAO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15082510 31160049
ESR1 CRH â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8408641
CRHR1 GNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10598591 22869609
CRHR1 GNAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10598591 22869609
ESR1 CXCL12 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18563714
ESR1 CXCL12 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16912174
CYSLTR2 GNAS â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
DOCK1 FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ESR1 NOS3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17921256 0704315104
ESR1 RAC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21118977 11060289
ESR1 GNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19170076 18414489
ESR1 PTPN6 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 6673088 7539106
ESR1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 3677090
ESR1 WNT4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20126574
ESR2 TBXA2R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17660955 16199482
SRC F2R â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16580177 9924018
F2RL2 F2R â—¼   PROXIMITY 2.0 0.8 intact 17376866 0700763104
F2R GNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22318735 31160049
PLCG1 F2RL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
SRC F2RL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
FYN F2RL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
SRC F2RL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17474147
F2RL3 GNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17158345 31160049
FRK RAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17318185 5219684
PIK3R2 FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15536084 11907067
LCK FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8946678 9973466
FYN GABBR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
FYN PIK3CB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15536084 11907067
FYN PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12670391 8621607
SMO FYN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18455992 23074268
FYN LCK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17570479 22043010
WNT11 FZD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16273260 15578921
WNT4 FZD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 14671310
SMO GABBR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
PIK3R1 GABBR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GABBR2 GABBR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218685 16724110
PRKACA GABBR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11976702
GCG GNB1 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
GCG GNAI1 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
GCG GNAS â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
PIK3R1 GNA11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16268778 18515384
GNA11 PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16268778 18515384
GNA11 PDCL â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25675501 15889144
GNA11 GNB4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25675501 15889144
GNA11 GNAQ â—¼   GTPASE_REACTION ✅ 2.0 0.8 Reactome 8073283 7937899
GNA11 GNA15 â—¼   GTPASE_REACTION ✅ 2.0 0.8 Reactome 8073283 7937899
GNA11 PLCB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12578375 27515033
GNA11 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15313914
GNA11 PLCB2 â—¼   PHOSPHOLIPASE ✅ 2.0 0.8 Reactome 11015615 2841328
GNA11 PLCB4 â—¼   PHOSPHOLIPASE ✅ 2.0 0.8 Reactome 11015615 2841328
GNA11 PLCB1 â—¼   PHOSPHOLIPASE ✅ 2.0 0.8 Reactome 11015615 2841328
PIK3R1 GNA15 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16268778 18515384
GNA15 GNB4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25675501 15889144
GNA15 PDCL â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25675501 15889144
GNA15 PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16268778 18515384
GNA15 GNAQ â—¼   GTPASE_REACTION ✅ 2.0 0.8 Reactome 8073283 7937899
GNA15 PLCB2 â—¼   PHOSPHOLIPASE ✅ 2.0 0.8 Reactome 11015615 2841328
GNA15 PLCB1 â—¼   PHOSPHOLIPASE ✅ 2.0 0.8 Reactome 11015615 2841328
GNA15 PLCB4 â—¼   PHOSPHOLIPASE ✅ 2.0 0.8 Reactome 11015615 2841328
GNAI1 P2RY12 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11196645 8554519
OPRM1 GNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12068084 31160049
LPAR1 GNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 31160049 12393875
SMO GNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23074268 16885213
GNB1 GNAI2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7102203 16782902
GNAI2 P2RY12 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11196645 8554519
SMO GNAI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23074268 16885213
GNAI3 P2RY12 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11196645 8554519
SMO GNAI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23074268 16885213
OPRM1 GNAI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15082510 31160049
LPAR1 GNAI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9600933 31160049
PIK3CA GNAQ â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16268778 18515384
PIK3R1 GNAQ â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16268778 18515384
GNAQ GNB4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25675501 15889144
GNAQ PDCL â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25675501 15889144
LPAR1 GNAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 31160049 20331961
GNAQ PLCB1 â—¼   PHOSPHOLIPASE ✅ 2.0 0.8 Reactome 11015615 2841328
GNAQ PLCB4 â—¼   PHOSPHOLIPASE ✅ 2.0 0.8 Reactome 11015615 2841328
GNAQ PLCB2 â—¼   PHOSPHOLIPASE ✅ 2.0 0.8 Reactome 11015615 2841328
SMO GNAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23074268 16885213
SMO GNAT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23074268 16885213
GNAT3 P2RY12 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11196645 8554519
GNB1 TRPM3 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
GNB1 P2RY12 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11196645 8554519
TBXA2R GNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15782186 12399457
SMO GNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23074268 16885213
GNB1 TBXA2R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15782186 12399457
GNB5 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23109003 17169327
GNB5 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23109003 17169327
HCK PIK3R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12029088 5215418
HCK PIK3R2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12029088 5215418
HLA-DRA LCK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
MYC HLA-DRB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17881904 18544564
HRAS SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12695509 5216326
PTPN11 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 26617336
HRAS PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9069260 21779497
PIK3R1 LCK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5220762 8246987
PIK3R2 LCK â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15536084 11907067
LCK PTPN11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18173375 18759926
LCK PIK3CB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15536084 11907067
LCK PTPN6 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 8114715 7028063
PIK3CD LYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11598010 12506011
LYN PIK3CB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11598010 12506011
LYN PIK3R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11598010 12506011
LYN PIK3R5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11598010 12506011
LYN PLCG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15644415 8034732
LYN PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11598010 12506011
MAPK11 PAK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MAPK11 MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23602568 21900206
MYC PRKACA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15197457 12420224
MYC PIK3R1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19602047 11509615
PDYN OPRM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7905839 8208289
POMC OPRM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7905839 8208289
RAC1 PAK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11278486 11804587
PAK1 RAF1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 17097642 5219317
PIK3CD PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9885561 10455108
PIK3CA PIK3CB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9885561 10455108
RAC1 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9148763 10592173
PIK3CA RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9148763 10592173
PIK3CD PIK3CB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9885561 10455108
PIK3R2 PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8596638 11733063
PIK3CG RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15009099 23331499
PLCG1 PIK3R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6805619 9020117
PIK3R2 RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12515821
PRKACA PLCB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 8657310 9660757
PLCB4 PLCB1 â—¼   PHOSPHOLIPASE ✅ 2.0 0.8 Reactome 11015615 2841328
PLCB2 PLCB1 â—¼   PHOSPHOLIPASE ✅ 2.0 0.8 Reactome 11015615 2841328
PLCB2 PLCB4 â—¼   PHOSPHOLIPASE ✅ 2.0 0.8 Reactome 11015615 2841328
PLCG1 PTPN11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6805619 9020117
RAC1 PTK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18212043 18066058
SRC PTK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6672010 16291744
PTPN11 SRC â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 8288622 20308328
SRC YES1 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
GNG2 KCTD12 â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
GNB1 KCTD12 â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
ARHGEF6 PAK1 â—¼   PHYSICAL_INTERACTION 806.0 0.8 STRING 36370105
LCK CD3E â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 11855827 14523017
BCAR1 FYN â—¼   PHYSICAL_INTERACTION 816.0 0.81 STRING 36370105
GNAI3 GNB2 â—¼   PHYSICAL_INTERACTION 819.0 0.81 STRING 36370105
ARRB1 ELMO2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
LPAR1 CXCR4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
PAK1 ESR1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 12374744 16452229
KCNJ3 KCNJ9 â—¼   PHYSICAL_INTERACTION 820.0 0.82 STRING 36370105
KCNJ3 KCNJ6 â—¼   PHYSICAL_INTERACTION 820.0 0.82 STRING 36370105
RPTOR PREX1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17565979 21339740
PIK3CG PIK3R5 â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
CNR2 GNAI1 â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
CXCR2 GNAI1 â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
FPR2 GNAI1 â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
GNAI1 NTSR1 â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
POLB GNAI1 â—¼   KO_DOWN_REGULATES ✅ - -0.83 0.82 PKG 28854368
GNB1 GPR52 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
ADORA1 GNB1 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
CNR1 GNB1 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
CNR2 GNB1 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
CXCR2 GNB1 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
FPR2 GNB1 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
GNB1 NTSR1 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
GNAQ PLCB3 â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
GCGR GNAI1 â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
GNAS SCTR â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
ARRB1 NTSR1 â—¼   PHYSICAL_INTERACTION 828.0 0.82 STRING 36370105
CALCRL GNAS â—¼   PHYSICAL_INTERACTION 828.0 0.82 STRING 36370105
CALCR GNG2 â—¼   PHYSICAL_INTERACTION 829.0 0.82 STRING 36370105
CALCRL GNG2 â—¼   PHYSICAL_INTERACTION 829.0 0.82 STRING 36370105
GNG2 SCTR â—¼   PHYSICAL_INTERACTION 829.0 0.82 STRING 36370105
GNG2 PTH1R â—¼   PHYSICAL_INTERACTION 829.0 0.82 STRING 36370105
GLP1R GNG2 â—¼   PHYSICAL_INTERACTION 830.0 0.83 STRING 36370105
GCGR GNG2 â—¼   PHYSICAL_INTERACTION 830.0 0.83 STRING 36370105
ARMC1 ATP4A â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
CXCR2 ARRB1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 11170396 16189514
RRP7A ATP4A â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
CALCR GNB1 â—¼   PHYSICAL_INTERACTION 830.0 0.83 STRING 36370105
CALCRL GNB1 â—¼   PHYSICAL_INTERACTION 830.0 0.83 STRING 36370105
CXCR4 GNA13 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 11994484 23773523
ELMO2 DOCK1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 32203420 11703939
GNA11 GNB1 â—¼   PHYSICAL_INTERACTION 830.0 0.83 STRING 36370105
GNAI1 GNAT3 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
GNB1 SCTR â—¼   PHYSICAL_INTERACTION 830.0 0.83 STRING 36370105
RAF1 LCK â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 8939988 16189514
WNT4 WNT5A â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
GLP1R GNB1 â—¼   PHYSICAL_INTERACTION 831.0 0.83 STRING 36370105
GCGR GNB1 â—¼   PHYSICAL_INTERACTION 831.0 0.83 STRING 36370105
CD247 CD3D â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CD3D CD3G â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
GCG GCGR â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
PTK2 YES1 â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
LCK PTPN6 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
AR SRC â—¼   PHYSICAL_INTERACTION 839.0 0.83 STRING 36370105
ARRB2 SRC â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
ESR1 HDAC4 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 16051668 19893013
LYN HCK â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 32707033 31980649
HLA-DRB1 HLA-DRA â—¼   PHYSICAL_INTERACTION ✅ 0.84 0.84 mint 5220278 7477400
GNB1 PREX1 â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
GNAI2 GNB4 â—¼   PHYSICAL_INTERACTION 844.0 0.84 STRING 36370105
ADRBK1 GNAQ â—¼   PHYSICAL_INTERACTION 849.0 0.84 STRING 36370105
BCAR1 LCK â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 9020138
BTK HCK â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 8058772 32707033
SRC LYN â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 22581261 32707033 18070987 9169421
SRC PLCG1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 8657103 7510703 7682059 1689310 16713569 8885868
GLP1R GNAS â—¼   PHYSICAL_INTERACTION 856.0 0.85 STRING 36370105
GCGR GNAS â—¼   PHYSICAL_INTERACTION 859.0 0.85 STRING 36370105
GNB1 PTH1R â—¼   PHYSICAL_INTERACTION 859.0 0.85 STRING 36370105
DOCK1 SRC â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 17474147 12615911
GNAI1 GNAI2 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
ADRBK1 GNG2 â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
ADORA1 GNAI2 â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
CDC42 PIK3R1 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
GNB2L1 SRC â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
PTK2 PTPN11 â—¼   PHYSICAL_INTERACTION 869.0 0.86 STRING 36370105
LYN BTK â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 11598012 8058772 8629002 8630736 11226282
GNAI1 CNR1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 11168387 28734930
STRN ESR1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 15569929 31527615
GNAI1 GNAI3 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
HCK PIK3CB â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
LYN PTPN6 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
RAC1 PREX1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 27150042 32203420
CALCA CALCRL â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
HRAS PIK3CA â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
GNAI2 GNG2 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
ESR1 ESR2 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
GNB1 PDCL â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
PIK3R2 PIK3R3 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
PIK3R1 PTK2 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
PIK3R1 PIK3R2 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
CALCA RAMP1 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
CD247 LCK â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
ADM RAMP2 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
CD4 CXCR4 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 15660419 10816381 14592831
CDC42 RAC1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 31871319 9427749
SRC ESR2 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11032808 12630920 15604093 11013076 12095943
LYN FGR â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 32707033 31980649 34079125
GNAI3 GNB4 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
GNB1 GNB2L1 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
GNAI2 GNAI3 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
CALCRL RAMP3 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
SCT SCTR â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
CD3D CD3E â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
GNA13 TBXA2R â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
GNAS PTGIR â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
SRC ADRB2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 11013230 17170700
CDC42 MCF2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10854437 32203420
DOCK1 RAC1 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
SRC FYN â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 16966330 31980649 28514442 19711372 9169421
RAF1 FYN â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 7517401 16189514 16713569
GNAI3 GNAT2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 28514442 26186194
PLCB1 GNAQ â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 16754659 11753430 12193606
PIK3R1 SRC â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
ADRB2 ARRB2 â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
GNAQ TBXA2R â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
BCAR1 PTK2 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
MYC POLB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
GNB5 PLCB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23109003 17675482 17169327
HCK PXN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9636140 16809022 23109003
AR CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17617741 20610535 22040886
PF4 CXCL8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15531763 12586630
RHO GNG2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8406495 16634148 2534964
OPN1SW GNG2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8406495 16634148 2534964
OPN1MW GNG2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8406495 16634148 2534964
OPN1LW GNG2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8406495 16634148 2534964
GNG2 BTK â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11742120 11698416 7567982
GNG2 GPER1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15705806 15539556 17379646
OPN1SW GNG2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 8406495 16634148 2534964
OPN1MW GNG2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 8406495 16634148 2534964
RHO GNG2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 8406495 16634148 2534964
OPN1LW GNG2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 8406495 16634148 2534964
SMO GNB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23074268 17251915 16885213
GNB2 GRK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 1325672 8416978 1962211
ADORA1 GNAZ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9166747 16713569 31160049
GNA14 GRK2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10567430 16339447 10727532
GNA14 BTK â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9770463 11742120 9305846
GRK2 GNA11 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10567430 16339447 10727532
GRK2 GNAQ â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10567430 16339447 10727532
GRK2 GNA15 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10567430 16339447 10727532
ESR1 ADCYAP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20034404
ESR2 ADORA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19376833
ADORA1 GNAO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16713569 31160049 10521440
AR UCN â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 23801677
AR CRH â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16446741
AR PIK3R1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22740037 12063252 20610535
PAK1 ARHGEF6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
ARHGEF6 CDC42 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15649357 15306850 25241761
ARRB2 ARRB1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 17353931 24069330 28514442 17620599
BCAR1 LYN â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 9020138 9581808
MYC BLK â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
GNAQ BTK â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9770463 11742120 9305846
GNB1 BTK â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11742120 11698416 7567982
GNA15 BTK â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9770463 11742120 9305846
GNA11 BTK â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9770463 11742120 9305846
PLCG1 CD247 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7517665 8657103 15161916
CD3G PLCG1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7517665 8657103 15161916
CHRM4 GNAI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7916637 10347206 31160049
CNR1 GNAI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15082510 11168387 31160049
UCN CRHR2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 20966082 8612563 18801728
MYC CXCR4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10229837 11145693
ESR2 ESR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 19022902 19746436 10706629 12630920 9473491 21182203 29509190 17991765
SRC ESR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 17043237 17284441 17400812 15604093 11032808 17921256 18451880 15020686 12736255 11564893 23065768 10454579 20935677 17363140 16957778 14963108 11013076 29720121 15784253 24498420 17627277 12630920 22328528 14766010 24051437 7539106 27420286 15140878
ESR1 WNT5A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20034404
ESR1 PRKACA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11457657 10949931 17068199
ESR1 SRC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20160136 20460377 22865929
F2R GNA15 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16189514 10644723 31160049
PRKACA FYN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20658524
LPAR1 GNA13 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 31160049 15856019 20331961
OPRM1 GNAO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15082510 31160049 8393523
PTGIR GNAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10446129 31160049 11443126
GNAS GPER1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15705806 15539556 17379646
GNB1 GNAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15782186 16189514 26186194
OPN1LW GNAT1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 8406495 16634148 2534964
OPN1SW GNAT1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 8406495 16634148 2534964
OPN1SW GNAT1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8406495 16634148 2534964
RHO GNAT1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8406495 16634148 2534964
RHO GNAT1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 8406495 16634148 2534964
OPN1MW GNAT1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8406495 16634148 2534964
OPN1MW GNAT1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 8406495 16634148 2534964
OPN1LW GNAT1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8406495 16634148 2534964
OPN1LW GNAT2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8406495 16634148 2534964
RHO GNAT2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 8406495 16634148 2534964
OPN1LW GNAT2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 8406495 16634148 2534964
OPN1SW GNAT2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 8406495 16634148 2534964
OPN1MW GNAT2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8406495 16634148 2534964
OPN1SW GNAT2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8406495 16634148 2534964
RHO GNAT2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8406495 16634148 2534964
OPN1MW GNAT2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 8406495 16634148 2534964
OPN1MW GNB1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8406495 16634148 2534964
OPN1LW GNB1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8406495 16634148 2534964
RHO GNB1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8406495 16634148 2534964
OPN1SW GNB1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8406495 16634148 2534964
GNB1 GPER1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15705806 15539556 17379646
OPN1LW GNB1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 8406495 16634148 2534964
OPN1MW GNB1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 8406495 16634148 2534964
OPN1SW GNB1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 8406495 16634148 2534964
RHO GNB1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 8406495 16634148 2534964
HRAS PAK1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15520807 17462920 20363321
PRKACA KCNJ4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11749379 8893032 19635485
LCK RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7935389 8939988 16189514
LCK MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24863062 15735648
LCK PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7682059 17570479 1500851
LYN PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10318860
MAPK11 MAPK14 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MAPK14 PRKACA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15649893
MYC RAF1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 28205554 17314511 28628118 9315742
OPN1LW RHO â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 8406495 16634148 2534964
OPN1SW OPN1LW â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 8406495 16634148 2534964
OPN1LW OPN1MW â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 8406495 16634148 2534964
OPN1SW OPN1MW â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 8406495 16634148 2534964
OPN1MW RHO â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 8406495 16634148 2534964
OPN1SW RHO â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 8406495 16634148 2534964
PAK1 RAF1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11733498 12551923 17097642 9823899 9234708 10205168
RAF1 PAK1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15520807 17462920 20363321
PTPN11 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10386953 7522233
PTK2 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11119718 10592173 7537275
PIK3R2 PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22402981 8596638 11733063
PIK3R1 PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8596638 14665640 11733063
SRC PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25814554 22402981
PTK2 PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25814554 22402981
PIK3R3 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25814554 22402981
SRC PLCG1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15879121 20807769 11600407
SRC RAF1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 7517401 8876196 17097642 16189514 10205168
PTK2 PXN â—¼   PHOSPHORYLATION ✅ + 0.9 0.9 Signor 15688067
BCAR1 SRC â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
GNAI1 GNB4 â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
PIK3R1 PTPN11 â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
PXN BCAR1 â—¼   UP_REGULATES ✅ + 0.91 0.91 Signor 27447856
ESR1 SRC â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
CD247 CD3E â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
GABBR2 KCTD16 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
ADM CALCRL â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
PTK2 SRC â—¼   PHYSICAL_INTERACTION 931.0 0.93 STRING 36370105
CD3E CD3G â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
GNAI1 SMO â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
CALCRL RAMP2 â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
PIK3CB PIK3R3 â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
CNR1 GNAI1 â—¼   PHYSICAL_INTERACTION 935.0 0.93 STRING 36370105
GNB1 SMO â—¼   PHYSICAL_INTERACTION 936.0 0.93 STRING 36370105
PIK3CB PIK3R2 â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
PXN PTK2 â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 25795725
CD3G CD3E â—¼   PHYSICAL_INTERACTION 0.94 0.94 HIPPIE 9582308 2138083 20890284
ADCYAP1 GNG2 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
ADCYAP1 GNAS â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
GNB1 RHO â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
PIK3CA PIK3R3 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
FYN YES1 â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
HRAS PIK3CG â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
GNG2 SMO â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
GNG2 NTSR1 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
GNG2 HTR1B â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
PIK3CB PIK3R1 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
PTK2 PXN â—¼   PHYSICAL_INTERACTION 948.0 0.94 STRING 36370105
CDC42 PREX1 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
ADRBK1 GNB1 â—¼   PHYSICAL_INTERACTION 953.0 0.95 STRING 36370105
GNB1 HTR1B â—¼   PHYSICAL_INTERACTION 953.0 0.95 STRING 36370105
GNAS GNG2 â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
FYN SRC â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
SRC BCAR1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 10085298 21034468 10487518 11514617 10542110 15020686 16849545 12397603 12615911 17038317 10739664 12972425 17129785
PAK1 CDC42 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 7744004 12879077 23455922 15548653 10802735 24276241 31871319 10684602 21167153 19596003 12606577 10360579 18057010 20936779 11157984 25150978 18426980 21029865 12650940 9705280 8107774 23175184 21048135 31478661 9535855 16678097
RICTOR MTOR â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 24036451
MTOR RICTOR â—¼   COLOCALIZATION ✅ 0.97 0.97 mint 21045808 8088164
PIK3R1 PIK3CA â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 20018188 7383613
CALCRL RAMP1 â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
CD4 LCK â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
GNAS GNB1 â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
RAF1 HRAS â—¼   PROXIMITY ✅ 0.98 0.98 mint 18273062 6540139
HRAS RAF1 â—¼   PROXIMITY ✅ 0.98 0.98 mint 18273062 6540139
RPTOR MTOR â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 24036451
MTOR RPTOR â—¼   COLOCALIZATION ✅ 0.98 0.98 mint 21045808 8088164
RAC1 PAK1 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 5217506 15688026
GNAI1 GNG2 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
KCNJ3 KCNJ5 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
PIK3CD PIK3R1 â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
GNAI2 GNB1 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
PIK3CA PIK3R2 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
MTOR RPTOR â—¼   PHOSPHORYLATION ✅ + 0.98 0.98 Signor 19346248
GABBR1 GABBR2 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
GNAI3 GNB1 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
HLA-DRA HLA-DRB1 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
GNB5 GNG2 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CDC42 PAK1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
PAK1 RAC1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLB GNAS â—¼   KO_UP_REGULATES ✅ + 0.99 0.99 PKG 28854368
GNB2 GNG2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GNB3 GNG2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GNB4 GNG2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GNAI1 GNB1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GNB1 GNG2 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
HRAS RAF1 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
PIK3CA PIK3R1 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
RAMP1 CALCA â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 2177866 8626685 2985435 6609312 14722252
ADM2 RAMP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 21658025 30139742 12684503
ADM RAMP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11693189 30139742 15361343 15692146 12565884 9620797
CALCA RAMP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 14722252 11693189 11033437 12565884 11023820 26125036 30139742 12234182 15692146 9620797
ADM RAMP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11693189 30139742 12565884 9620797
RAMP2 ADM â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 8387282 11693189 10217420 9620797 14615490
ADM2 RAMP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21658025 30139743 20596793 32196115
RAMP2 ADM2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 8387282 11693189 10217420 9620797 14615490
CALCA RAMP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 14722252 11033437 12565884 16531504 30139742 15692146 9620797
RAMP3 ADM2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 8387282 11693189 10217420 9620797 14615490
ADM RAMP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11693189 27391260 12565884 30139742 15692146 10347248 14712479
ADM2 RAMP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 27013657 21658025 20596793 30139742
RAMP3 ADM â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 8387282 11693189 10217420 9620797 14615490
CALCA RAMP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 14722252 11693189 11033437 12565884 30139742 15692146 10347248
SRC RACK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 26.0 1.0 Omnipath 21685945 12400005 23652203 22174419 16849317 9584165 11279199 17574549 16189514 21978545 21677780 22523568 18596232
RACK1 FYN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11943848 12524444 16713569
PRKACA PLCB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 28615442 9660757 10893237
GCG GLP1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 18248821 11116211 15528268 7937318 8404634
PXN DOCK1 â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 11146654 12432077 14697347 15308668 16000375 18287025 22043013 29021139 9808620
PXN BCAR1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 ACSN 12473693 14749719 15094799 15308668 15688067 16000375 18287025 18829532 18835194 22043013 29021139 9819392
PXN BCAR1 â—¼   SHARES_COMPLEX 12.0 1.0 ACSN 12473693 14749719 15094799 15308668 15688067 16000375 18287025 18829532 18835194 22043013 29021139 9819392
CD247 PXN â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 10562324 10925299 11353765 11438547 11875494 12415267 12731048 12811837 15735648 16713974 17371980 20435894 20814939 21059766 23414611 23508573 23620508 23886063 24378531 7600293 8478617 8642247 9625766 9738502
CDC42 PXN â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10934474 11248548 11340065 15001467 15003621 15020669 15169870 15882626 16329184 17517963 17785506 18719708 19741094 21178402 22126964 22821962 27248291 7761442 9831565
FYN PXN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 7617039 10804218 16713569 23128389
PTK6 PXN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 17081983 15572663 15592455 18676874 18083107 7537852 17389395 7493940 7615549 19534553 11774284 15107421 12408869 10823820 16254239 15817476 16094384 19304789 16212419 21423176 15951569
PTPN11 PXN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 23397142 10082579 8986614 10655584 14665621
PAK1 PXN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 26598620 10330411 11096073 16717130 14580336 18986306 27542844 28214467 25472536 17440071 23317503
PTK2 PXN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 109.0 1.0 Omnipath 16298995 26053221 15688067 15572663 15592455 7963537 17389395 25405379 26546726 9658172 15107421 22581436 10823820 16254239 25226367 15817476 10330411 9756887 19543320 9054445 10545505 18707149 29127427 15494312 10764815 7537852 9442086 33823745 12408869 20419088 20655620 22270917 18669648 28373581 10455189 16094384 23936270 19138410 22638989 11337490 11514617 27402964 16713569 7615549 10931187 11774284 26700725 27708220 20068231 20473365 28928239 7561682 34475475 28427224 28068967 8922390 24885567 23209645 27669437 15212693 26711338 9422762 11304546 28214467 26697169 12065577 28415719 10753828 11919182 24364863 9230116 11113628 21741599 10417825 15252114 24642576 22044652 21034468
SRC PXN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 46.0 1.0 Omnipath 9636140 28214467 15572663 15592455 16713569 14665621 25795725 7537852 7615549 25405379 11774284 26700725 25182764 15107421 7534286 2472406 12408869 11695992 17570479 10823820 7525621 20103658 16254239 15817476 23109003 27447856 28626446 16094384 18363833 19543320 24364863 28376152 19138410 25323586 27941878 23457577 10085298 22638989 27669437 15212693
PXN BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11313252 9418872 11577104 9759889 8810278
CXCL8 CXCR2 â—¼   PHYSICAL_INTERACTION 15.0 1.0 ACSN 15079071 17533374 17784835 17916596 18555777 18555778 18633355 18980965 21328342 21847358 23869868 24406209 25922287 26201938 27557510
PTPN11 CXCL8 â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 10358138 11447289 11449354 11572860 12138178 1238444 12393695 12421919 12707331 15169881 15240681 15699106 15713798 16204085 17307799 19406987 19479342 19833085 20363967 20435894 21469115 22483603 22683124 22955274 27557510 9751747
ESR1 CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 15208657 16029657 19440537 14991571 18669446 17932106
CXCL8 CXCR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 70.0 1.0 Omnipath 7592830 8702798 22904195 9195914 10699158 7559482 12628493 23597562 10188995 15946947 8626516 8550564 9553055 1379593 8662882 19190236 8245475 9126332 10216072 1891716 9485196 8940121 15282370 9464567 11350788 11511101 9725262 10206993
PDYN GNG2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9544801 16415903 11786497 10215864
ADORA2B GNG2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 2553705 3127824 9651336 12106601 12860470
POMC GNG2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9544801 16415903 11786497 10215864
OPRM1 GNG2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9544801 16415903 11786497 10215864
STRN GNG2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11689445 27288742 11369763 25587652
ESR1 GNG2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11689445 27288742 11369763 25587652
GNG2 PDCL â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 25675501 15889144 23637185 16717095
ADORA2B GNG2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 2553705 3127824 9651336 12106601 12860470
GNG2 CYSLTR1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 10191087 3086311 16754659 1905813 8664309
GNG2 CYSLTR2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 10191087 3086311 16754659 1905813 8664309
GNB1 GNG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23739333 8636150 9789084 10339615 12606627 15889144 15782186 11294873 18611381 10696571 19376773 12782285 19168127
GNG2 PREX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16847462 17430994 21640127 12297047 21736902 11955434
GNG2 GNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23739333 8636150 9789084 10339615 12606627 15889144 15782186 11294873 18611381 10696571 19376773 12782285 19168127
GNB3 PREX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16847462 17430994 21640127 12297047 21736902 11955434
GNB2 PLCB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 1465133 9307019 8387502 1465134 8306983
GNB2 PREX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16847462 17430994 21640127 12297047 21736902 11955434
PAK1 GNAZ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10531372 9166747 7559455 8429024
SCT SCTR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 7612008 7782300 9440501 8579602
GNA14 POMC â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9544801 16415903 11786497 10215864
GNA14 PDYN â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9544801 16415903 11786497 10215864
GNA14 OPRM1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9544801 16415903 11786497 10215864
GNA14 CYSLTR2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 10191087 3086311 16754659 1905813 8664309
GNA14 CYSLTR1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 10191087 3086311 16754659 1905813 8664309
ADRB2 GRK2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 8672451 8514797 16687412 2871555
GRK2 SMO â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 14636583 16908539 16630821 15691767 20844016 24925320 18815277 24845016 21695114 17960137 23719536 14614827
PRKACA GRK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11278469
SRC GRK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12624098 16725308 11278940 11566877 16189514
GRK2 MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17055984
GRK2 ADRA2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 19651622 7876239
GRK2 ADRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 96278816 23473322 8662852 10499588 18056263
GRK2 SMO â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21695114 15618519 23074268
GRK2 OPRM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 12123746 18463167 10488100 22375000 11861651 21292762
GNAS ADCY2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9228084 9395396 1719547 9268375 21406690
ADCYAP1 ADCYAP1R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 8703026 16930633 12488235 10583729 11931347 21350482 10100920 17470806 8253796
ADM CALCRL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11693189 10347248 9620797
ADM CALCR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 10781016 12565884 15692146
ADM2 CALCR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 21658025 15692146
CALCRL ADM2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 8387282 11693189 10217420 9620797 14615490
ADM2 CALCRL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 21658025 14615490
ESR1 ADORA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19935720 19376833 18414489
ADORA1 GNAI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 3805010 6305455 6162091 31160049
ADORA2B GNAS â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 2553705 3127824 9651336 12106601 12860470
ADORA2B GNB1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 2553705 3127824 9651336 12106601 12860470
ADORA2B GNAS â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 2553705 3127824 9651336 12106601 12860470
ADORA2B GNB1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 2553705 3127824 9651336 12106601 12860470
ADRA2A GNAO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11732925 31160049 1849000 7887906
ARRB2 ADRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 23208550 17148612 17666399 24658140 27226565 2163110 24561123 22364396
PRKACA ADRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 9461522 24003153 10753752 11146000 2987243 27481942 27646272
ADRB2 GNAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12036966 15782186 23798571 6149763
ESR1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8299561 11000528 22391641
AR SRC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19305643 10454563 18687691 17108144 17079466
AR PRKACA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12933667 10075669 9886819 15691881
MAPK14 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 30644418 24424504 21820033 16282370
SRC AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 28144231 15062576 20570899 25133482 21318111 11032808 25950519 21512132 17525795 12933816 20383201 24728074 24948875 24868554 25547388 19117998 21956655 17045208 15027889 24859991 15466214 26829214 21886458
AR ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 12389206 11032808 16713569 11000528 18988627
ARHGEF6 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23455922 11157752 9659915 10592173 15688026 21900206
SRC ARRB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 17456469 17456551 16432186
ARRB1 GNAI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520
ARRB1 GNAI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520
ARRB1 GNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520
SMO ARRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15618519 23074268
MAPK14 ARRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12738796 18039929 11274345 15187187
ARRB2 GNAI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520
ARRB2 GNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520
ARRB2 GNAI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520
BCAR1 DOCK1 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 11146654 12094222 12432077 14697347 15308668 16000375 16076871 18835194 22464172 9808620
BCAR1 DOCK1 â—¼   SHARES_COMPLEX 10.0 1.0 ACSN 11146654 12094222 12432077 14697347 15308668 16000375 16076871 18835194 22464172 9808620
PTK6 BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15870699 25938342 22084245
FYN BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 17129785 9188452 9020138 10739664 31413325 16713569 11181827 9360983 17474147
LYN BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 9581808 9020138 10428862
PTK2 BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 48.0 1.0 Omnipath 8649427 7479864 12135674 15673687 8810278 9038154 8670206 9285683 11604500 11119718 12480533 24939893 8621540 11577104 9360968 9148935 10592173 12119061 12972425 9360983 10092764 21855630 10753828 11839772 18233957 10545505 12615911 8662921 11514617
HCK BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9020138
SRC BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 62.0 1.0 Omnipath 19901323 24962474 11514617 8670206 15316024 20927395 8070403 17389395 12480533 22710723 30422386 25976166 17570479 21963850 12972425 20103658 17129785 10487518 15817476 21301050 10739664 17038317 21765460 17016520 12397603 15212693 15020686 10542110 23457577 10085298 12615911 15272013 21034468 11604500
BLK PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11369622 15728464 12590707 10753828
LYN BTK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 18083107 8629002 12573241 11598012 19369195 10051622 9012831 8630736 9730885 10811866 9052864 8058772 11226282
SRC BTK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 19109164 23170196 8629002 29455639 10051622 8630736 26165234 9052864
BTK PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9550384 15010370 15184383
CALCA CALCRL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 17145710 11693189 8626685 3001670 16293613 12234182 14668209 23597562 10347248 9620797
CALCA CALCR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 48.0 1.0 Omnipath 14722252 9487987 7588285 11033437 2158663 1331173 11023820 26125036 10342886 6148938 15692146 12565884
CCL20 CXCR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9660793
HLA-DRA CD247 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
CD4 CD247 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
FYN CD247 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10591186 10648627 11062502 12218089 12731048 15536084 19290918 19909365 20814939 21378271 22683124 22863785 24440149 27192565 9738502
HCK CD247 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 12524384 21910624 24445665 8064233 8132624 8478617
LCK CD247 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10652356 11062502 12731048 12740575 15536084 17544292 19290918 20814939 21127503 22513334 23620508 8478617 8986721 9438848 9738502 9751747
CD4 CD247 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10398592 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 3263576 8478617 8986721 9438848 9738502 9751747
PTPN11 CD247 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10358138 10849428 10982827 11447289 11572860 12138178 12640133 12707331 15240681 15699106 15713798 16212621 19833085 19909365 9751747
LYN CD247 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 12524384 19909365 21910624 24445665 26552706 8064233 8132624 8478617 8892616
CD247 PLCG1 â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 10562324 10925299 11353765 11438547 11875494 12415267 12731048 12811837 15735648 16713974 17371980 20435894 20814939 21059766 23414611 23508573 23620508 23886063 24378531 7600293 8478617 8642247 9625766 9738502
CD247 PTPN11 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 12947224 15358536 18173375 18759926
CD247 PTPN6 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 12947224 15358536 18173375 18759926
LCK CD247 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 9047237 19229850 23109003 16461343 1706070 1505025 16337488 17979845 8626561
PTPN6 CD247 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 14672952 11238643 23109003
FYN CD247 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 8578591 12522270 7589084 9677202 9047237 15144186 1454062 1530920 15592455 16094384 9368621 16713569 96108162 15659558 8760790
HLA-DRA CD3D â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
CD4 CD3D â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
CD3D LCK â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
CD3D PTPN6 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 12947224 15358536 18173375 18759926
CD3D PTPN11 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 12947224 15358536 18173375 18759926
CD4 CD3E â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
HLA-DRA CD3E â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
CD3E PTPN6 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 12947224 15358536 18173375 18759926
CD3E PTPN11 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 12947224 15358536 18173375 18759926
LCK CD3E â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12522270 2470098 15144186 11855827 15592455 16094384 15659558
CD3E PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9312149 11855827 11689561
CD4 CD3G â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
HLA-DRA CD3G â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
LCK CD3G â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
CD3G PTPN11 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 12947224 15358536 18173375 18759926
CD3G PTPN6 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 12947224 15358536 18173375 18759926
LCK CD4 â—¼   PHYSICAL_INTERACTION 16.0 1.0 ACSN 10398592 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 3263576 8478617 8986721 9438848 9738502 9751747
CD4 PTPN6 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 12947224 15358536 18173375 18759926
CD4 PTPN11 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 12947224 15358536 18173375 18759926
CD4 LCK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 16888650 8104794 11854499 8246987 3262426 12601806 17653867 23109003 12007789 16189514 17005671 15489916 15047060
CDC42 DOCK1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15710388 15247287 12134158 17196961 17027967
SRC CDC42 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 11476890 12094222 16919435 17496910 17517963 25572304 26552706 27216177
PIK3R1 CDC42 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 7629060 8034624 9381982
SRC CDC42 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 14506284 26816343 9626657
MCF2 CDC42 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 32203420 9490022 9113980 10816584 17045588 8836113
CDC42 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 7629060 8034624 9381982
CDC42 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 60.0 1.0 Omnipath 17145710 810774 10360579 21167153 8107774 10559936 9705280 12650940 16678097 23331499 21029865 10684602 18057010 15020669 21070974 11340065 21048135 15003621 20936779 10934474 11413130 15788770 15713627 9535855 23109003 11950587 19628037 7744004 12879077 12606577 24276241 10224076 19596003 8973630 19812368 11248548 10802735 18719708 10613909 10461188 23455922
ESR1 CRH â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 18597742 18404132 8408641 17947358 9408232 15126558 12161509 15564578
ESR2 CRH â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 18597742 8408641 17947358 12161509 15564578
CRH CRHR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 52.0 1.0 Omnipath 8612563 8536644 19124613 7477349 11416224 9178757 7692441 9851694 20966082 11123370 9326293 10598591 18801728
CRH CRHR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 8536644 8243338 23504413 11123370
UCN CRHR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 8612563 9423932 11416224 11123370 15450949
UCN CRHR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 8612563 9423932 10816663 11416224 11123370 15450949
CXCL12 CXCR4 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 15261139 15882617 17035340 20535745 20644254 21521526 22025564 23034983 23402812 23567181 24277834
CXCL12 CXCR4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 24023874 10233851 10699158 11859124 22633458 18648536 18448868 8752280 30476826 12714578 16725153 9712844 8752281 9551924 21757744 19837984 25495026 26582643 16626895
CXCL12 CXCR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9660793
CXCR2 MAPK14 â—¼   UP_REGULATES ✅ + 8.0 1.0 ACSN 17254968 17533374 18555777 18633355 18980965 21328342 23869868 24954210
PF4 CXCR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 21655676 12782716 10699158
CXCR4 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11668182
CXCR4 GNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520 10506573
CXCR4 GNAI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520
CXCR4 GNAI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520
GNA11 CYSLTR1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 10191087 3086311 16754659 1905813 8664309
GNAQ CYSLTR1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 10191087 3086311 16754659 1905813 8664309
GNB1 CYSLTR1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 10191087 3086311 16754659 1905813 8664309
GNA15 CYSLTR1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 10191087 3086311 16754659 1905813 8664309
GNA15 CYSLTR2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 10191087 3086311 16754659 1905813 8664309
GNB1 CYSLTR2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 10191087 3086311 16754659 1905813 8664309
GNA11 CYSLTR2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 10191087 3086311 16754659 1905813 8664309
GNAQ CYSLTR2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 10191087 3086311 16754659 1905813 8664309
FYN DOCK1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15788770 11817894 18212043 18066058 12149262
DOCK1 RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 17145710 15723800 15247908 9808620 25533347 10592173 12134158
GNAT3 ESR1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11689445 27288742 11369763 25587652
ESR2 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 14754635 24284820 15207704 18784357 11566442 12630920 22820289 19001520 18511514 14676837 19207817 22622808 21763263 18339713 15087130
ESR1 NOS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22052999 11029009 10690351 14742696 19914929
ESR1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 22396492 21835891 15073177 18193094 11517191 21505052 22892083 8707895 19569049 14722073 18414489
MAPK14 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23216744 22431515 12138194 15879307
PAK1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 18521086 26944939 16778166 18755239 21893191 15178330 19205871 29548483 26554417 27003261 24505617 16452229 15193262 19557173 15642175 12374744 19465939 17604944 25447917 20179234
LCK ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 9500442 10571988 25386784 11145737 7539106 27748765
SRC ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 15784253 25364741 17400812 16957778 17627277 15140878 11032808 23065768 12736255 7539106 17921256 27472465 14963108 24487689 25275301 12630920 22865929 14766010 30148069 11013076 15020686 9500442 17284441
PRKACA ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 22266331 9891036 15193262
ESR1 ESR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 12630920 9473491 19746436 21182203 10706629 10022879
ESR1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11029009 11689445 16169518 23065768 16713569
ESR2 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11013076 12095943 12630920 11032808
F2R GNA12 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8290554 16189514 31160049 22972936
F2R GNA13 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 8290554 20223821 10922491 16189514 22318735 22972936 21331223
GNAI2 FGR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23109003 11007482 11160627 10753828 9722546
GNAI1 FGR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23109003 11007482 10753828 9722546
FGR PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 63.0 1.0 Omnipath 32051585 27790061 12590707 28692661 14610060 15728464 12495636 28377405 10593973 16510472 11369622 14603053 26710849 9148935 20160475 29743287 24608426 12408869 14572662 24655477 26530902 34237080 11438458 12659633 26068982 15126359 14978737 18676832 27270311 12023386 11331870 15800067 23109003 7597091 33674746 8051157 11891289 22761432 19962670 20180147 24858039 11035755 10753828 11857088 15611137 7529876 15389641 33715263 15077193 17234784 8824286 34161758 10821872 12754219 12087088 15316068 22751010 32049010 12531888 12387730
FGR PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21780115 15032589 11526404 23109003 22880054 10488096
FGR PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21780115 15032589 11526404 23109003 22880054 10488096
PIK3CD FYN â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9590251 7537740 8995358 9259313
LCK FYN â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 9822663 15886116 10849438 12670394
FYN PTPN11 â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 10591186 10648627 12218089 12731048 19290918 19909365 20814939 21378271 22683124 22863785 24440149 27192565 9738502
FYN PTPN11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10212213 11157475 16713569
FYN PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 7515100 1334406 16713569 1652056
FYN PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 11369622 12558988 15494733 20151426 12590707 16293639 7505391 15728464 11278857 16713569 10753828 15494732 10085136 15494734
FYN PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8395016 10586033 7682059 16713569
FYN MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15735648
FYN PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 8294442 8394019 7515100 17570479 16713569 7520528 1652056
WNT5A FZD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16273260 21903638 15578921 17804197 24032637
WNT5A FZD6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16273260 21665003
WNT4 FZD6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 10557084 15265686 21541287
GCG GCGR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 22863277 4305077 8382034 12529935
POMC GNA11 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9544801 16415903 11786497 10215864
PDYN GNA11 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9544801 16415903 11786497 10215864
GNA11 OPRM1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9544801 16415903 11786497 10215864
GNA11 PLCB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 1333052 3017978
LPAR1 GNA12 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22863277 31160049 15856019 20331961
TBXA2R GNA13 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 8290554 10395940 15782186 31160049 10488151 12399457
PRKACA GNA13 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 12399457
POMC GNA15 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9544801 16415903 11786497 10215864
PDYN GNA15 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9544801 16415903 11786497 10215864
GNA15 OPRM1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9544801 16415903 11786497 10215864
STRN GNAI1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11689445 27288742 11369763 25587652
GNAI1 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23109003 11007482 10753828 9722546
GNAI1 HCK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23109003 11007482 10753828 9722546
STRN GNAI2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11689445 27288742 11369763 25587652
GNAI2 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23109003 11007482 11160627 10753828 9722546
GNAI2 HCK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23109003 11007482 11160627 10753828 9722546
GNAI2 LYN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23109003 11007482 11160627 10753828 9722546
STRN GNAI3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11689445 27288742 11369763 25587652
OPRM1 GNAQ â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9544801 16415903 11786497 10215864
POMC GNAQ â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9544801 16415903 11786497 10215864
PDYN GNAQ â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9544801 16415903 11786497 10215864
TBXA2R GNAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23962128 20590159 15134434 12726995 12193606 9152406 15782186 21940795 31160049 12399457
GNAQ PLCB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11753430 1309799 12193606 16754659 8245028 8387502 1322796 1846707
GNAT3 STRN â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11689445 27288742 11369763 25587652
OPRM1 GNB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9544801 16415903 11786497 10215864
STRN GNB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11689445 27288742 11369763 25587652
PDYN GNB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9544801 16415903 11786497 10215864
POMC GNB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9544801 16415903 11786497 10215864
GNB1 PREX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16847462 17430994 21640127 12297047 21736902 11955434
PDCL GNB4 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 25675501 15889144 19376773 16717095
GNB4 PREX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16847462 17430994 21640127 12297047 21736902 11955434
GNB5 PREX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16847462 17430994 21640127 12297047 21736902 11955434
HCK PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17145710 21780115 11526404 15032589 23109003 12029088 22880054 10488096
HCK PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11369622 12590707 23109003 15728464 9148935 12495636 10753828 25814554 7529876 10593973
HCK PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 17081983 16497976 15592455 16126727 17389395 1689310 20068231 16153436 16038803 10586033 1708307 7682059 15144186 12601080 18707149 8885868 8657103 17016520
HCK PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17145710 21780115 11526404 15032589 23109003 12029088 22880054 10488096
PRKACA HDAC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22865920 20716686
HLA-DRA LCK â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
HLA-DRA PTPN11 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 12947224 15358536 18173375 18759926
HLA-DRA PTPN6 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 12947224 15358536 18173375 18759926
PIK3R2 HRAS â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
RAF1 HRAS â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 10358164 11532940 12566895 14764585 15516985 16102570 19289794 19565474 24027568 7510700 8551221 9069260 9763606 9846483
HRAS PIK3CB â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
RAF1 HRAS â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 10358164 11532940 12566895 14764585 15516985 16102570 19289794 19565474 24027568 7510700 8551221 9069260 9763606 9846483
RAF1 HRAS â—¼   ENZYMATIC_REACTION ✅ 14.0 1.0 ACSN 10358164 11532940 12566895 14764585 15516985 16102570 19289794 19565474 24027568 7510700 8551221 9069260 9763606 9846483
SRC HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12695509 9626657 9020108 25157176 33413561
HRAS PIK3CD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9069260 9113989 9235916 21779497 11739523 10545207
HRAS PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9069260 9727023 17145710 10922060 11136978 21779497
HRAS RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 147.0 1.0 Omnipath 17145710 18273062 9523700 1639773 8601312 19595761 20133694 11032808 9154803 10882715 14654780 1996324 19222999 16301319 11948414 8530446 7969158 11313862 9150145 20080631 1990291 12750173 15031288 12932319 9665134 8805624 8340422 1386920 23331499 16916524 16041367 23180781 18988627 20178605 15688026 15664191 22169110 11733498 7862125 8180183 19063885 12391160 9144171 8035810 9020159 14724584 19696784 21779497 9261098 12173045 12620389 8628317 19914712 1708096 19933846 26721396 7730360 10205168 8332187 16803888 18775988 12917261 9099670 10545207 25684575 8670882 10783161 12379659 10887184 17569879 21071413 8332195 7523381 10531446 24929361 8503013 16093354 19541618 10369681 8911690 18073111 11136732 10922060 7760835 11134016
HRAS PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9069260 25241761 10212255 11313862 9150145 16713569 15021914
HRAS PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 9069260 9113989 8052307 24412244 17540175 9931431 11313862 14724584 10592173 9150145 8665852 10783161
PRKACA KCNJ12 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11181181
PRKACA KCNJ12 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11181181
PRKACA KCNJ3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19151997
LCK PTPN6 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 12947224 15358536 18173375 18759926
LCK PTPN11 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 12947224 15358536 18173375 18759926
LCK PTPN6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 23071622 8692915 16231973 23109003 14699166 19167335 12459785 12468540 11294838 10574931 7512963 16497976 16189514 14757045 8114715 10488096
LCK PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 8294442 11337495 8246987 14583609 11526404 15032589 23109003 9461588 7504174 8397196 10488096
LCK PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11369622 12590707 15728464 9257837 10753828
LCK PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11526404 15032589 14583609 23109003 8397196 10488096
LYN PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21780115 15032589 11526404 23109003 22880054 10488096
LYN PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 21780115 29145629 12506011 18453587 11526404 10455108 15032589 23109003 23180781 9334184 15149544 10194437 22880054 11598010 10488096
LYN PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 9169439 11369622 11389892 12590707 23109003 15728464 9148935 12495636 10753828 25814554 7529876 10593973
LYN PTPN6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 19171907 11042209 8692915 14699166 22624718 19690332 12468540 10574931 17570479 18083107 14757045 8114715 10488096 28811476
LYN PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 45.0 1.0 Omnipath 17389395 12601080 8395016 16038803 10586033 1689310 20068231 1708307 7682059 8885868 15144186 16497976 8657103 15592455 16126727 17016520 16153436
RAC1 MTOR â—¼   PHYSICAL_INTERACTION 56.0 1.0 ACSN 10702316 10722653 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16556040 16678438 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18481918 18492954 18570873 18925875 19022819 19027299 19143635 19143636 19151919 19225151 19244117 19446321 19568798 19706736 19720745 19864431 20027184 20138985 20338997 20547845 20805416 21157483 21474067 21533173 21621563 21708191 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MTOR RPTOR â—¼   PHYSICAL_INTERACTION 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
MTOR RICTOR â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10722653 11274345 11756498 12408816 12906785 16469695 16556040 16678438 17461779 17680028 18000759 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19151919 19446321 19568798 19706736 19720745 20027184 20338997 21157483 21474067 21533173 21621563 21708191 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
RAC1 MTOR â—¼   SHARES_COMPLEX 56.0 1.0 ACSN 10702316 10722653 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16556040 16678438 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18481918 18492954 18570873 18925875 19022819 19027299 19143635 19143636 19151919 19225151 19244117 19446321 19568798 19706736 19720745 19864431 20027184 20138985 20338997 20547845 20805416 21157483 21474067 21533173 21621563 21708191 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MTOR RICTOR â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10722653 11274345 11756498 12408816 12906785 16469695 16556040 16678438 17461779 17680028 18000759 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19151919 19446321 19568798 19706736 19720745 20027184 20338997 21157483 21474067 21533173 21621563 21708191 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MTOR RPTOR â—¼   SHARES_COMPLEX 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
RAC1 MTOR â—¼   ENZYMATIC_REACTION ✅ 56.0 1.0 ACSN 10702316 10722653 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16556040 16678438 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18481918 18492954 18570873 18925875 19022819 19027299 19143635 19143636 19151919 19225151 19244117 19446321 19568798 19706736 19720745 19864431 20027184 20138985 20338997 20547845 20805416 21157483 21474067 21533173 21621563 21708191 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MTOR RPTOR â—¼   ENZYMATIC_REACTION ✅ 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
MTOR MYC â—¼   ENZYMATIC_REACTION ✅ 23.0 1.0 ACSN 12150925 12408816 12906785 15755954 16469695 17604271 17680028 18372248 18492954 19022819 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
RAC1 MTOR â—¼   DOWN_REGULATES ✅ - 56.0 1.0 ACSN 10702316 10722653 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16556040 16678438 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18481918 18492954 18570873 18925875 19022819 19027299 19143635 19143636 19151919 19225151 19244117 19446321 19568798 19706736 19720745 19864431 20027184 20138985 20338997 20547845 20805416 21157483 21474067 21533173 21621563 21708191 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MTOR RPTOR â—¼   LOCALISATION ✅ 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
RPTOR MTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 139.0 1.0 Omnipath 15268862 24403073 20427287 22258093 21321085 19446321 15467718 19875983 17461779 12665511 12719976 16631613 21045808 21177249 23911927 24337580 25446900 24516643 18614546 12718876 12747827 16603397 17043309 18519641 22544753 25007995 27043084 19145465 23953116 19619545 16919458 24375676 15459249 16837165 16847060 25332233 12150926 22424946 26348909 12150925 18955708 20381137 22356909 17386266 17565979 18030348 16354680 20169205 19114562 21071439 27329724 35561222 16798736 15809305 22493283 17277771 15661536 16962653 1683716516603397 17604271 18676370 16183647 18505677 23297343 23872070 24036451 15066126 18570873 21614075 18722121 12408816 17599906
RPTOR MYC â—¼   ENZYMATIC_REACTION ✅ 23.0 1.0 ACSN 12150925 12408816 12906785 15755954 16469695 17604271 17680028 18372248 18492954 19022819 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
PRKACA NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 15319357 12522122 34204249 10376603 31923467 16839566 33429979 34026871 16946136 10908731 10671564 16270749 11729179 12171920 26132171 11978735 17572401 24379783 10376602 16873402
PDYN OPRM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9686407
POMC OPRM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15464143
PLCG1 PAK1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 19124833 9989831 15548136 19574218
RAC1 PAK1 â—¼   UP_REGULATES ✅ + 11.0 1.0 ACSN 11121431 11274345 11544274 11756498 15157156 15229651 18000759 19151919 24459205 27331412 9655398
RAC1 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 130.0 1.0 Omnipath 17145710 15229651 21167153 8107774 24792722 16551621 14579272 10023776 8805275 18325335 11134022 19693014 19277120 21474670 12650940 15673687 19961560 20711231 11950930 16678097 12123608 19270716 9744077 9148763 11689432 23331499 21029865 16368433 11121431 16492808 15075243 21454543 10592173 24172987 15212766 7493928 10793146 21070974 10706722 8910277 17245428 25819133 20936779 11030651 9989831 15157156 9535855 19359598 25150978 16049136 18854161 19628037 15688026 12879077 7744004 11728826 16002993 9764820 9032259 25843002 10224076 19732720 19596003 10802735 19893577 16212495 11130076 12480336 11152757 19327867 22117219 22581261
PAK1 RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 67.0 1.0 Omnipath 28007610 19421139 26333361 22096607 15849194 12952546 30197477 12551923 23162742 25733387 17097642 22105362 18465753 23331499 24924700 10801448 26257058 21917714 12719581 11376654 25843685 15664191 19165420 23576562 23506953 10205168 24505617 28415790 18775988 22983922 9234708 12952943 16129686 25472536 11733498 11948406 9823899 11897507
SRC PIK3CA â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 12682286 15314172 20861220 18657504 11689445 12431978 25587652 11044445 22266855 11029403 11029009
STRN PIK3CA â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 12682286 15314172 20861220 18657504 11689445 12431978 25587652 11044445 22266855 11029403 11029009
PIK3R3 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 8596638 22402981 9415396 11733063 26496610 25814554
SRC PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12750372 10592173 17275257 10830300
PIK3R3 PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 8596638 22402981 11733063 25814554
PIK3R1 PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 8596638 25241761 20713702 27107012 11733063 21825134 32814053 26496610 8139559 14729945 10358930 14665640
PIK3CB PREX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16847462 17430994 21640127 12297047 21736902 11955434
PIK3R1 PIK3CD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9113989 8596638 21827948 12147247 11733063 22020336 24165795 31031754 14665640
PIK3CG PREX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16847462 17430994 21640127 12297047 21736902 11955434
STRN PIK3R1 â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 12682286 15314172 20861220 18657504 11689445 12431978 25587652 11044445 22266855 11029403 11029009
PTPN11 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 11593409 18950707 15790353 23109003 16371368 17722974 22315502 16107703 9660791 9918857 8080844 9632795 10973965
PTPN6 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 21780115 11337495 11526404 15032589 9065461 11160222 23109003 22880054 10488096
PTK2 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10806474 8649427 7537275 10973983 12554777 16713569 9416004 19889638
PIK3R1 RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 7629060 8034624 12086876 12515821
SRC PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21780115 15032589 11526404 23109003 22880054 10488096
PTPN6 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21780115 15032589 11526404 23109003 9065461 22880054 10488096
PTPN11 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 18950707 23109003 16371368 17722974 22315502 16107703 9660791 8080844 9632795 15790353
PIK3R5 PREX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16847462 17430994 21640127 12297047 21736902 11955434
PLCG1 SRC â—¼   PHYSICAL_INTERACTION 36.0 1.0 ACSN 10072481 10781611 10811803 10925299 11169415 11476890 11532940 11994416 12040186 1281218 12845332 14585353 14764585 15214048 16488589 16919435 1712101 17397400 17496910 17517963 19568798 19909365 23523669 24584707 2536067 25456276 25572304 25960930 26552706 27216177 7682895 7890616 8226994 8649391 9535722 9846483
PLCG1 SRC â—¼   SHARES_COMPLEX 36.0 1.0 ACSN 10072481 10781611 10811803 10925299 11169415 11476890 11532940 11994416 12040186 1281218 12845332 14585353 14764585 15214048 16488589 16919435 1712101 17397400 17496910 17517963 19568798 19909365 23523669 24584707 2536067 25456276 25572304 25960930 26552706 27216177 7682895 7890616 8226994 8649391 9535722 9846483
SRC PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 43.0 1.0 Omnipath 8388373 16497976 16126727 16713569 17389395 1689310 20068231 17570479 16153436 16038803 1708307 7682059 7510703 18594017 12601080 8885868 8657103 17016520
PTK2 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 8660853 26278977 10430888 23397142
PRKACA PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 1370476 2479646
PRKACA PREX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 23109003 16301320 32661198 26797121 22242915
PREX1 RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 21172654 15611338 32203420 11955434 15967165 27150042 12829230
SMO PRKACA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 20016067 23331499 20643644 20956384 21209912 18820483 17641202 17688959 18997815 19549984 19592253 14611647
PRKACA TBXA2R â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11749379 10827090 7961988 12147288 14530262 11389883
PRKACA SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 19651622 17081983 20166139 2474754 18088087 15546918 19664994 11804588
PRKACA RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 53.0 1.0 Omnipath 19007248 11971957 20166139 18767875 20230923 9001246 10576742 23331499 20068231 7935389 18669648 18691976 9922370 15664191 19651622 12801936 9091312 10862777 9710607 11997508
SRC PTK2 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 11476890 12531888 16919435 17496910 17517963 20027185 25572304 26552706 27216177 8892616
SRC PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 216.0 1.0 Omnipath 27351421 23242524 16254240 12370821 21940449 26142360 17525734 10593973 14604860 17389395 19171305 22402981 19339212 22353809 9748249 8941336 17570479 12464388 25226367 15611085 15817476 25241761 26393679 27978555 26833789 11927607 17828307 25913180 26866924 15247219 10085298 12387730 19055942 9507031 21454698 10973994 32814053 21057587 27931517 27438371 18793427 19695571 15735019 18560762 10592173 25319025 24389213 21852560 26689988 14984767 7505391 19568240 20103658 20822514 25868388 23275294 28423510 23764511 19625610 15561106 17192257 19138410 19369195 17088251 12753909 28701735 29190494 17016520 15598735 18814847 11821402 11418135 15728464 16291744 25067788 11602246 16713569 22287273 9032297 7997267 12960434 11369622 20616959 26079101 19534553 10931187 22710722 20068231 25866790 21347260 9822703 28202937 16153436 11980671 21855630 19826415 18464795 7529876 20621036 9330873 21473875 9425168 28956212 12615911 15951569 25814554 12876384 17438336 15212693 16966330 20705914 20847951 23729178 20407018 12558988 25127991 25918719 12590707 16360410 8054685 18814027 11696015 22800863 17117420 12495636 11278488 9864370 21776383 18083107 22814579 22194915 20515733 11119718 9148935 10428489 15743500 20655298 23065768 28213315 26923073 24015220 17289681 12110680 22006118 24164353 23109003 18935208 10753828 18233957 8816475 25118939 19664994 25530216 16760434 9330875 21266176 21034468
YES1 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11369622 12558988 16293639 12590707 25868388 15728464 25416956 32296183 10753828 23397142
PTPN11 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 23335101 7589239 10082579 21726809 14572662 15561106 8986614 16189514 10655584 19698715 16920701 15598735
PTK2 RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20936779 22163037 26816343 29036929 34252134
PTPN11 PTPN6 â—¼   PHYSICAL_INTERACTION 42.0 1.0 ACSN 10358138 11447289 11449354 11572860 12138178 12176909 1238444 12393695 12421919 12707331 12773515 12917349 15169881 15240681 15699106 15713798 16204085 17371980 19833085 20007250 20038811 20363967 20435894 21469115 22437870 22483603 22513334 22683124 22952938 22955274 23732914 25355530 26667266 26755705 26885856 27474009 27806234 28893624 8976179 8986721 9751747 9765283
PTPN11 PTPN6 â—¼   SHARES_COMPLEX 42.0 1.0 ACSN 10358138 11447289 11449354 11572860 12138178 12176909 1238444 12393695 12421919 12707331 12773515 12917349 15169881 15240681 15699106 15713798 16204085 17371980 19833085 20007250 20038811 20363967 20435894 21469115 22437870 22483603 22513334 22683124 22952938 22955274 23732914 25355530 26667266 26755705 26885856 27474009 27806234 28893624 8976179 8986721 9751747 9765283
PTPN11 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 18757826 18482983 10698938 17974954 14687660 24632723 20308328
SRC PTPN6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 8692915 17675340 14551136 25535246 14699166 12468540 10574931 16649996 8647855 7512963 9261115 34010642 14757045 12468645 8114715 15212693 10488096 21900501
WNT5A RAC1 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 19365405 18719708 11751577 12533515 9716412 11779461 9674432 23109420 15608632
RAC1 RICTOR â—¼   PHYSICAL_INTERACTION 40.0 1.0 ACSN 10722653 11274345 11756498 12408816 12906785 16469695 16556040 16678438 17461779 17680028 18000759 18481918 18492954 18570873 18925875 19022819 19027299 19143635 19151919 19446321 19568798 19706736 19720745 20027184 20338997 21157483 21474067 21533173 21621563 21708191 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
RAC1 RPTOR â—¼   PHYSICAL_INTERACTION 40.0 1.0 ACSN 10702316 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18000759 18372248 18492954 19022819 19143636 19151919 19225151 19244117 19446321 19568798 19706736 19864431 20138985 20547845 20805416 21157483 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
RAC1 RPTOR â—¼   SHARES_COMPLEX 40.0 1.0 ACSN 10702316 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18000759 18372248 18492954 19022819 19143636 19151919 19225151 19244117 19446321 19568798 19706736 19864431 20138985 20547845 20805416 21157483 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
RAC1 RICTOR â—¼   SHARES_COMPLEX 40.0 1.0 ACSN 10722653 11274345 11756498 12408816 12906785 16469695 16556040 16678438 17461779 17680028 18000759 18481918 18492954 18570873 18925875 19022819 19027299 19143635 19151919 19446321 19568798 19706736 19720745 20027184 20338997 21157483 21474067 21533173 21621563 21708191 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
RAC1 RPTOR â—¼   ENZYMATIC_REACTION ✅ 40.0 1.0 ACSN 10702316 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18000759 18372248 18492954 19022819 19143636 19151919 19225151 19244117 19446321 19568798 19706736 19864431 20138985 20547845 20805416 21157483 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
RAC1 RPTOR â—¼   DOWN_REGULATES ✅ - 40.0 1.0 ACSN 10702316 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18000759 18372248 18492954 19022819 19143636 19151919 19225151 19244117 19446321 19568798 19706736 19864431 20138985 20547845 20805416 21157483 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
SRC RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22163037 17991704 21798346 26816343 29036929
SRC RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 7692235 12551923 7517401 17097642 15258589 9689060 16189514 16630891 10998357 11376654 29063113 8876196 10205168 28846113 12952943 22592532 11134016 15710605 16170185
STRN SRC â—¼   PHYSICAL_INTERACTION 18.0 1.0 Reactome 17916740 27288742 17921256 21851428 11689445 15956360 12431978 12388769 17037979 22028449 11369763 12808053 21680538 22266855 11029403 12511868 19879889 11029009
POLB GNG2 â—¼   KO_UP_REGULATES ✅ + 1.03 1.03 PKG 28854368
POLB GNAO1 â—¼   KO_DOWN_REGULATES ✅ - -1.54 1.53 PKG 28854368
POLB LCK â—¼   KO_DOWN_REGULATES ✅ - -1.56 1.55 PKG 28854368
POLB POLB â—¼   KO_DOWN_REGULATES ✅ - -7.24 7.23 PKG 28854368