Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
TBX2 SHH â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17300775 17519333
GATA6 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19501129 17463088
DISP3 SHH â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 15645143
AKT1 SP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21619873 21777568
GLI2 BMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19103752 16880529
CDON BOC â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11782431 9786951
TWIST1 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22290439 20818389
SSRP1 CP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15979198 15240830
DISP2 SHH â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 15645143
GLI2 FOXA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19360354
FOXA2 MSX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22696295 24431302
GLI1 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19028702 21666711
GLI1 HHIP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19860666 16571352
GLI2 HHIP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16571352 19574535
GPC3 SHH â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 18505598
HNF1B SHH â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11731484 11763995
RUNX2 LEF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20890621 19650108
LEF1 RUNX2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16575901 16043491
TP53 MAP2K1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10529175 9724739
MSX1 RUNX2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15136142 11390985
MSX1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15705871
MYOD1 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18094043
MYOD1 TP73 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18513743 16007124
OTX2 SHH â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11291866 15105370
P4HB SHH â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 21357747 21257310
PAX6 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 23970099 19618119
TP53 POU4F2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17145718 25356872
RORA SHH â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19381306
TP53 SHH â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17050669 21042410
SP7 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22110141 22750006
SYVN1 TP53 â—¼   COLOCALIZATION 2.0 0.8 intact 17170702 5219455
TP53 TWIST1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18504427 20689556
TP73 TP63 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19815500 0905867106
SEL1L VCP â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
EDEM1 DERL2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17360537 32423001
OS9 EDEM3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28514442 28366632
RARA KLF5 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 16224062 18466769 21383775 16102021 12101409
SEL1L OS9 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 29496332
PTCH2 SMO â—¼   PHYSICAL_INTERACTION 839.0 0.83 STRING 36370105
DERL2 OS9 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
SYVN1 DERL1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 16186510 29743537 16289116 24807418 23867461 19864457 26471130
RORA MYOD1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 16713569 9862959
RARA AKT1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 23693014 16417524
OTX2 FOXA2 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 10623575 16713569 12642491
SMO PTC1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11278759 9811851
TP53 TP63 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
OS9 VCP â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
ERLEC1 SYVN1 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
PTCH1 SMO â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
CDKN2A TP53 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
DERL1 SYVN1 â—¼   PHYSICAL_INTERACTION 899.0 0.89 STRING 36370105
CDO1 SHH â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16647304 23331499
ADAM17 SHH â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 19176481 21664575 23118222
MYOD1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10973962 16901893 21689744
AKT1 FOXA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14500912 23416070
LEF1 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19340300
PAX6 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20053773 11584062 17157287
VCP DERL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17145710 15215856
VCP DERL2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 21357747 23867461 19002207
SYVN1 DERL2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 21357747 23867461 19002207
DISP1 SHH â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22902404 23331499 14556242
DISP2 SCUBE2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 22677548 22609552 22902404
EXTL1 SHH â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 15614771 11944914
GLI1 SHH â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19384336 16855373 9247260
MSX1 MYOD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15192231 10529415 7664340
NR2F2 MYOD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9826778
SHH SCUBE2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 22677548 22609552 22902404
VCP SEL1L â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 21357747 23867461 19002207
TP53 SYVN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16980608
TP73 TP63 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16413471 21436470 18026135
TP73 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11238924 19815500 10373484
VCP DERL1 â—¼   PHYSICAL_INTERACTION ✅ + 0.9 0.9 Signor 15215856
ERLEC1 SEL1L â—¼   PHYSICAL_INTERACTION 902.0 0.9 STRING 36370105
HHIP SHH â—¼   PHYSICAL_INTERACTION 931.0 0.93 STRING 36370105
SHH PTCH1 â—¼   PHYSICAL_INTERACTION ✅ - 0.93 0.93 Signor 15618519
SHH HHIP â—¼   PHYSICAL_INTERACTION 0.94 0.94 HIPPIE 10050855 19561609
CDON SHH â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
DERL2 SYVN1 â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
DERL2 SEL1L â—¼   PHYSICAL_INTERACTION 950.0 0.95 STRING 36370105
PTC1 SHH â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 31253779 30139912 9811851 29954986 16282375 19561609
DERL2 VCP â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
OS9 SEL1L â—¼   PHYSICAL_INTERACTION 970.0 0.97 STRING 36370105
OS9 SYVN1 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
SEL1L SYVN1 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
DERL1 VCP â—¼   PHYSICAL_INTERACTION 979.0 0.97 STRING 36370105
PTCH1 SHH â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
SYVN1 VCP â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
GAS1 SHH â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 18794898 21664576 22326621 17504940 21664577 17504941 21842183
GAS1 PTCH1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 18794898 21664576 22326621 17504940 21664577 17504941 21842183
TBX2 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 20348948 16730707 25211658 19216023 15781639 11062467 18762810 20624445 15300007 17630961
GPC5 NOTUM â—¼   PHOSPHOLIPASE ✅ 6.0 1.0 Reactome 15647319 20412775 17967162 12015973 15963974 17609110
SHH NOTUM â—¼   PHOSPHOLIPASE ✅ 6.0 1.0 Reactome 15647319 20412775 17967162 12015973 15963974 17609110
GPC5 SHH â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15647319 20412775 17967162 12015973 15963974 17609110
TP53 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12485897 18661553 19763735
RELA AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20186924 18031796 20649564
SMO AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 20016067 20643644 20956384 21209912 18820483 17641202 17688959 18997815 19549984 19592253 16537363
AKT1 TWIST1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 25847239 26759241 29314610 27623213 20400976 28099910
AKT1 RARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16417524
AKT1 VCP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16551632 19335618 16027165
SHH BOC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 30613383 17086203 16647304
SHH BOC â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8906794 8906787 21664576 17086203 22326621 8898207 21664577 23719536
TWIST1 CDKN2A â—¼   DOWN_REGULATES ✅ - 7.0 1.0 ACSN 15640618 17936558 20818389 21383063 21678481 21685941 22796940
TP63 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 9151818 19340300 19554267 21093383 19672307 8995628
TP73 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12766778 18555006 11870517 18829110 11309270 14733783
TP53 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 16103197 22467867 18555006 8631601 11402335 19649205 22020338 21164364 17265068 16764954 15775976 22056554 18275833 21483786 10348346 19216023 12384561 12091906 19901969 11360201 15205322 11818069 21892281 10980602 11739748 11559812 24672805 10097151 17907153 19244234 15361884 10652576 9436028 21447739 20569441 21555589 21637567 10816133 9774662 19240179
FOXA1 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23443045 19340300
TWIST1 CDKN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 22796940 20818389 17690110 15640618
CDKN2A TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 15856024 15989956 9724636 19960022 12740913 17158541 12640129 19590512
SHH CDON â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 18794898 21664576 17086203 20519495 22326621 20844013 16647304 21664577 17504941 21802063
PTCH1 CDON â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 18794898 21664576 17086203 20519495 22326621 20844013 16647304 21664577 17504941 21802063
SHH CDON â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16647304 17086203
SHH CP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9811851 15618519 17419683 14556242
SHH DERL2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 19002207 21357747 18502753 18711132 18264092 23867461
OS9 DERL2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 19002207 21357747 18502753 18711132 18264092 23867461
DISP2 SHH â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 10619433 15110707 22902404 12372301 22677548 22609552
SHH ERLEC1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 19002207 18502753 18711132 19346256 18264092 21357747 23867461 23719536
VCP ERLEC1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 19002207 21357747 18502753 18711132 18264092 23867461
GLI1 FOXA2 â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 11001584 11274345 16054035 16396903 16406505 16880536 17000779 17439715 17638910 18754008 18813803 19081070 19190345 19219074 20107231 22354771 23031257 26587781 8545107
FOXA2 SHH â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 24968361 15468917 24431302 9233805 11763995 20849957
GLI2 FOXA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 18813803 16880536 19190345 18698484 15087129 17845852 19049965 11001584 20107231 20712011 15520176 16406505 17000779 16413481 16571352 16396903 9609833 18497536 14555646 9216996 11493558 15140221 16054035 20143239
GLI1 FOXA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 18813803 19219074 16406505 16880536 16054035 11001584 17000779 17439715 19190345 8545107 16396903 11274345 20107231
FOXA2 OTX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 10623575 16713569
SMO GLI1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 17641202 18820483 19081070 20215540 23031257
GLI1 PAX6 â—¼   ENZYMATIC_REACTION ✅ 27.0 1.0 ACSN 11001584 11960000 12138125 14555646 15087129 15520176 16054035 16158046 16328026 16396903 16406505 16571352 16880536 17000779 17035233 17638910 18754008 18813803 19081070 19190345 19219074 19736394 20107231 21059263 21442356 22354771 23031257
GLI1 NKX2-2 â—¼   ENZYMATIC_REACTION ✅ 27.0 1.0 ACSN 11001584 11960000 12138125 14555646 15087129 15520176 16054035 16158046 16328026 16396903 16406505 16571352 16880536 17000779 17035233 17638910 18754008 18813803 19081070 19190345 19219074 19736394 20107231 21059263 21442356 22354771 23031257
GLI1 PTCH1 â—¼   ENZYMATIC_REACTION ✅ 27.0 1.0 ACSN 11001584 11960000 12138125 14555646 15087129 15520176 16054035 16158046 16328026 16396903 16406505 16571352 16880536 17000779 17035233 17638910 18754008 18813803 19081070 19190345 19219074 19736394 20107231 21059263 21442356 22354771 23031257
GLI2 GLI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16571352 15175043 12165851 9636069
GLI1 PTCH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19860666 21076395 11719506 16571352 15087129
GLI2 GLI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 18813803 16880536 19190345 18698484 15087129 17845852 19049965 11001584 20107231 20712011 15520176 16406505 17000779 16413481 16571352 16396903 9609833 18497536 14555646 9216996 20581804 11493558 15140221 16054035 20143239
GLI1 NKX2-2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 16158046 18813803 19219074 16880536 21059263 11960000 19190345 15087129 21442356 16328026 19736394 11001584 12138125 20107231 15520176 16406505 17000779 16571352 16396903 14555646 17035233 16054035
GLI1 PTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 16158046 18813803 19219074 16880536 21059263 11960000 19190345 15087129 21442356 16328026 19736394 11001584 12138125 20107231 15520176 16406505 17000779 16571352 16396903 14555646 17035233 16054035
GLI1 PTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 16158046 18813803 19219074 16880536 21059263 11960000 19190345 15087129 21442356 16328026 19736394 11001584 12138125 20107231 15520176 16406505 17000779 16571352 16396903 14555646 17035233 16054035
GLI1 HHIP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 16158046 18813803 19219074 16880536 21059263 11960000 19190345 15087129 21442356 16328026 19736394 11001584 12138125 20107231 15520176 16406505 17000779 16571352 16396903 14555646 17035233 16054035
SMO GLI2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 17641202 18820483 19081070 20215540 23031257
GLI2 PTCH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 14691458 9636069 16571352 15087129 19574535
SMO GLI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 20016067 20643644 20956384 21209912 18820483 17641202 17688959 18997815 19549984 19592253
GLI2 PTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 18813803 16880536 19190345 18698484 15087129 17845852 19049965 11001584 20107231 20712011 15520176 16406505 17000779 16413481 16571352 16396903 9609833 18497536 14555646 9216996 11493558 15140221 16054035 20143239
GLI2 HHIP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 18813803 16880536 19190345 18698484 15087129 17845852 19049965 11001584 20107231 20712011 15520176 16406505 17000779 16413481 16571352 16396903 9609833 18497536 14555646 9216996 11493558 15140221 16054035 20143239
GLI2 PTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 18813803 16880536 19190345 18698484 15087129 17845852 19049965 11001584 20107231 20712011 15520176 16406505 17000779 16413481 16571352 16396903 9609833 18497536 14555646 9216996 11493558 15140221 16054035 20143239
HAND2 SHH â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12070084 16717186 20386744 20826535 22438573
SHH HHAT â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 24784881 21816240 16390857 11017805 15356051
HHAT SHH â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 15075292 18534984
SHH HHIP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 1005085510050850 19561609 10050855
PRKCD KLF5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12682370
MYF5 MYOD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15367664 20978076 14724123 12500905 10101129 14732408
VCP OS9 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 19002207 21357747 18502753 18711132 18264092 23867461
OS9 SHH â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 19002207 18502753 18711132 19346256 18264092 21357747 23867461 23719536
PAX6 SIX3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11069887 11069920 12072567
PRKCD TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17906639 16314418 16377624
PRKCD TP73 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12097319 21188172
SHH PTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 16282375 29995851 15618519 23331499 30613383 21339334 30139912 14556242 27647915 20083481 16867986 9811851 8906787 29954986
PTCH1 SMO â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 23331499 12192414 14556242 20207148 16867986 9811851 8906787 20076617
SHH PTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 9811851
PTCH2 SMO â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9811851 23331499 18988627
RARA VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15613498 17470563 18326047 11804877
RELA TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 18269916 10348347 11032029 8051093 20061391 15155458 21332394 9890939 21887328
RELA VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 18184402 17673602 16684540 15517885 12160329 15856023 18056465 20538607 17407600 20103608
TWIST1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 34881782 12553906
SHH SEL1L â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 19002207 21357747 18502753 18711132 18264092 23867461
SYVN1 SEL1L â—¼   PHYSICAL_INTERACTION 5.0 1.0 ACSN 12847084 16186509 18199748 18360008 19509052
SYVN1 SEL1L â—¼   SHARES_COMPLEX 5.0 1.0 ACSN 12847084 16186509 18199748 18360008 19509052
VCP SHH â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 19002207 21357747 18502753 18711132 18264092 23867461
SHH SMO â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 18754008 20495383 22354771 24856585
SHH VEGFA â—¼   DOWN_REGULATES ✅ - 4.0 1.0 ACSN 18754008 20495383 22354771 24856585
SHH SMO â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16867986 8906787
TP53 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 8108142 20639906 9377555 21325822 16684540 9833779 10910082 16835303 23449391 8521408 15860260 11971180 11559575
TP53 TP63 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 10606233 16931914 18388131 16516862 14576823 11382762 20442293 23019126 19858204 11238924 11423969
TP53 TP73 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11238924 18431400 21508668 9891077
TP53 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11238924 18431400 16713569
TWIST1 VEGFA â—¼   UP_REGULATES ✅ + 37.0 1.0 ACSN 11283614 11528470 12490555 13130303 14623871 15140942 15574337 15640618 15980428 16510505 16716598 16831886 17055429 17093497 17332325 17537911 17550342 17987801 18297062 18832382 19208835 19284610 19336515 20027199 20713526 20731704 20818389 21199805 21317430 21502402 21733352 2191300 21919891 22406545 22945800 7768934 9278421
TWIST1 VEGFA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17987801 16322226 16716598 13130303 7768934 15640618 11528470 9278421