Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
HSP90B1 ASPM â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
ATF6 SEL1L â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17967421
ATF6 HSP90B1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9837962
BRCA1 IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11001824 19223505
HIF1A BSG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19828020 22678117
CREB3 DCSTAMP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20546900 18952287
CREB3 UBE2J1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8153045 21516116
EGLN1 HIF1A â—¼   ENZYMATIC_REACTION ✅ 0.8 0.8 mint 7987706 20840591
HIF1A EGLN1 â—¼   HYDROXYLATION ✅ 0.8 0.8 mint 5217229 15474027
EGLN1 HIF1A â—¼   HYDROXYLATION ✅ 2.0 0.8 intact 5217229 15474027
EGLN3 HIF1A â—¼   HYDROXYLATION ✅ 2.0 0.8 intact 5217229 15474027
FOXM1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16809346 17875680
ESR1 HSP90B1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16511840 23038705
FOXM1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16809346
SEL1L FAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18711132 0805371105
VCP FAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18711132 0805371105
VCP FAF2 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
FAF2 VCP â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
OS9 FOXRED2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19706418 0900742106
SEL1L FOXRED2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19706418 0900742106
VHL HIF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218395 16511565
HYOU1 HSPA5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
VHL IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17486080 19509240
OS9 ITGB3BP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
LAMA5 SMAD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
LAMB2 ZNF512B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD2 OS9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
ZNF512B OS9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
PLOD2 PPIB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
PPIB SERPINH1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
ZNF512B VHL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
AMFR DERL2 â—¼   PHYSICAL_INTERACTION 806.0 0.8 STRING 36370105
SEL1L VCP â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
ZPBP2 OS9 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
ZPBP2 SE1L1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
LYZL2 EDEM1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
LYZL2 OS9 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
LYZL2 LAMB1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
LYZL2 TXD16 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
LYZL2 COEA1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
LYZL2 LAMB2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
LYZL2 SELN â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
LYZL2 LOXL2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
LYZL2 GT253 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
LYZL2 CNTP3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
LYZL2 TTC17 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
LYZL2 GLTL4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
OS9 P3H3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
OS9 ATF6A â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
OS9 PLXA1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
OS9 SORL â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
ERN1 SE1L1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26551274 19135427
FAF2 SE1L1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22119785 18711132
FXRD2 OS9 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 23097496 19706418
UD110 OS9 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
DB121 OS9 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
OS9 COEA1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
OS9 AGRIN â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
KLK5 GT253 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
OS9 GLTL4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
OS9 TM131 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
OS9 PLXA2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
OS9 CNTP3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
GGH TXD16 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
OS9 TXD16 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
OS9 SELN â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
OS9 B3GL2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
OS9 EMIL2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
OS9 ATF6B â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
OS9 COCH â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
EDEM1 DERL2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17360537 32423001
OS9 EDEM3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28514442 28366632
EGFR IGF1R â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17047074 17307140
OS9 EMB â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
OS9 EPHA4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
ESR1 HYOU1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25604459 19805454
HPSE OS9 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
KLK5 OS9 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
OS9 LAMA5 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
OS9 LAMB1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
OS9 LOXL2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
NAAA SULF2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
NAAA TTC17 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
SEL1L OS9 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 29496332
TMTC4 OS9 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
OS9 SULF2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
OS9 TTC17 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
TCEB1 ZYG11B â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
TCEB1 TCEB2 â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
FXRD2 TXD16 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 22119785
ANT3 OS9 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
FAF2 SARAF â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
OS9 GT253 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 28514442 23097496 33961781
GGH GT253 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
NAAA CNTP3 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
CALR3 OS9 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 26186194 31056421 34079125
DPEP2 OS9 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
NAAA EDEM1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
OS9 EGLN3 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 26972000 15721254
KLK5 FRAS1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
OS9 GGH â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 28514442 26186194 22119785
KLK5 LOXL2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
OS9 LONP2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 22119785
NAAA SYVN1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
NAAA OS9 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
AUP1 SEL1L â—¼   PHYSICAL_INTERACTION 833.0 0.83 STRING 36370105
AMFR ERLIN2 â—¼   PHYSICAL_INTERACTION 833.0 0.83 STRING 36370105
FAM8A1 SYVN1 â—¼   PHYSICAL_INTERACTION 833.0 0.83 STRING 36370105
CUL2 ZYG11B â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
ATF6A ATF6B â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 11158310 23661758
SE1L1 HYOU1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 26344197 27030672
OS9 SERPINA1 â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
DERL2 OS9 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
OS9 EGLN1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 15721254 21559462
VHL EGLN1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 22286099 17986458 26215701
SMAD2 ESR1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 11555647 20207742
ESR1 MYH9 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 25604459 19805454 21182205
IGF1R INSR â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
ENPL PPIB â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 24981860 22665516
CALR3 TXD16 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 28514442 34079125
DERL2 SERPINA1 â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
SE1L1 AUP1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 22119785 21857022 18711132 28827405
AUP1 SYVN1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 31056421 21857022 22119785 28827405
HIF1A CUL2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 23401859 27320910 18323857 17439941 17132228 19940151
EGFR ENPL â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 12471035 28065597 31980649 20029029
OS9 SE1L1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 24899641 23356641 19084021 19346256 18711132 28827405 26551274 29496332 18502753 23867461 23097496 21454652 22119785 18264092
FXRD2 SE1L1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 22119785 19706418
ESR1 EGFR â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11887937 17284441 20935677 28065597 16713569
HIF1A EGLN3 â—¼   HYDROXYLATION ✅ 0.88 0.88 mint 5217229 15474027
OS9 HIF1A â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 15721254 21118962
DERL2 FAF2 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
HSP90B1 OS9 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
OS9 VCP â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
ERLEC1 SYVN1 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
VHL CUL2 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 6542648 18323857
OS9 ENPL â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 24899641 21559462 26496610 23097496 22119785 18264092
SE1L1 SYVN1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 23356641 18711132 26424800 28827405 32614325 31477895 29496332 18502753 24807418 23867461 24366871 26471130 21454652 16186509 21903092 22119785 18264092
DNAJB11 HSPA5 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
SYVN1 ERN1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 26551274 18369366 19135427 26254280
ERN1 SYVN1 â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
AMFR FAF2 â—¼   PHYSICAL_INTERACTION 899.0 0.89 STRING 36370105
OS9 CUL2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 12351678 15652751 15721254
ACVR1B SMAD2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11024047 12063393 14978253
ATF6 SYVN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20160352 17967421 18664523
HSPA5 ATF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18624755 31226023
ESR1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11493692 27977889 10334989 11782371 16713569 17505062 15674350 19887647 20060929 11244506 16860316 17392432 31527615 16061635 16260778 12400015 1244506 25499220 29367421
BRCA1 ESR1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
COL6A1 DNAJB11 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
VCP DERL2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 21357747 23867461 19002207
SYVN1 DERL2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 21357747 23867461 19002207
HIF1A EGLN1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 26611735 23413029 16511565 16155211 20812988 22946054 27563096 33550096 18264140 16407130 20840591 24681946 31763849 15474027 17069766 20724477 34007068 25974097 29279301 15721254 17442832 25361009 17353276 19604478 18063574
OS9 EGLN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15721254 16391536
HIF1A EGLN3 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 24015760 18264140 26972000 23345396 18063574 16511565 16155211 15721254 30067985 18402654 31239290 15474027 25416956 17353276 17069766
OS9 EGLN3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15721254 16391536
FAM8A1 SYVN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 28827405 22119785
OS9 HIF1A â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 12351678 15652751 15721254
OS9 RBX1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 12351678 15652751 15721254
OS9 TCEB2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 12351678 15652751 15721254
OS9 TCEB1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 12351678 15652751 15721254
OS9 VHL â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 12351678 15652751 15721254
OS9 TRPV4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17932042
VCP SEL1L â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 21357747 23867461 19002207
ERLEC1 SEL1L â—¼   PHYSICAL_INTERACTION 902.0 0.9 STRING 36370105
LAMA5 LAMB1 â—¼   PHYSICAL_INTERACTION 907.0 0.9 STRING 36370105
EGLN3 HIF1A â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
AMFR VCP â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
EGLN1 HIF1A â—¼   PHYSICAL_INTERACTION 935.0 0.93 STRING 36370105
HSPA5 HYOU1 â—¼   PHYSICAL_INTERACTION 942.0 0.94 STRING 36370105
DERL2 SYVN1 â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
DERL2 SEL1L â—¼   PHYSICAL_INTERACTION 950.0 0.95 STRING 36370105
ERN1 HSPA5 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
DERL2 VCP â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
OS9 SEL1L â—¼   PHYSICAL_INTERACTION 970.0 0.97 STRING 36370105
FAF2 VCP â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
HIF1A TCEB2 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
HIF1A TCEB1 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
OS9 SYVN1 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
SEL1L SYVN1 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
CUL2 TCEB2 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
SYVN1 VCP â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
CUL2 RBX1 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
TCEB1 TCEB2 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
HIF1A VHL â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
RBX1 CUL2 â—¼   PHYSICAL_INTERACTION 21.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18420585 18931676 18985005 19622404 19622774 19686080 19809470 19847258
TCEB2 CUL2 â—¼   PHYSICAL_INTERACTION 21.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18420585 18931676 18985005 19622404 19622774 19686080 19809470 19847258
CUL2 VHL â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
CUL2 TCEB1 â—¼   PHYSICAL_INTERACTION 21.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18420585 18931676 18985005 19622404 19622774 19686080 19809470 19847258
RBX1 CUL2 â—¼   SHARES_COMPLEX 21.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18420585 18931676 18985005 19622404 19622774 19686080 19809470 19847258
TCEB2 CUL2 â—¼   SHARES_COMPLEX 21.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18420585 18931676 18985005 19622404 19622774 19686080 19809470 19847258
CUL2 TCEB1 â—¼   SHARES_COMPLEX 21.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18420585 18931676 18985005 19622404 19622774 19686080 19809470 19847258
CUL2 VHL â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
CUL2 HIF1A â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
ACVR1B SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 9346908 11389842 9892009 18988627 14517293
AMFR VCP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 20126661 22328510 16407162 16987818 17681147 26712280 16275660 21636303 17872946 18835813 19828134 22119785 23333620 23383273 26424800 21343306 21914798 16186510 15331598 17311810
ATF6 SYVN1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 17991856 18360008 23850759 26587781
ATF6 SEL1L â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 17991856 18360008 23850759 26587781
ATF6 HSP90B1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 17991856 18360008 23850759 26587781
ATF6 EDEM1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 17991856 18360008 23850759 26587781
ATF6 DNAJB11 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 17991856 18360008 23850759 26587781
ATF6 DERL3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 17991856 18360008 23850759 26587781
ATF6 HSPA5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 19667116 22189555 10856300 19622751 20165829 10866666 17117415 12076252 14973138 15899857 17241871 20801537 11256944 16452489 17522056 10564271 12713871
ATF6B HSPA5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17522056 14973138 11256944
BRCA1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11244506 12400015 15674350 10334989 16713569 11493692
SHH DERL2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 19002207 21357747 18502753 18711132 18264092 23867461
OS9 DERL2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 19002207 21357747 18502753 18711132 18264092 23867461
ESR1 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12894229 12421825 8200909 21705183
EGFR ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 20809984 17284441 16713569 11887937
HIF1A EGLN1 â—¼   ENZYMATIC_REACTION ✅ 66.0 1.0 ACSN 10102273 10428030 10428780 10435632 10804084 10823814 11557773 11559532 11744734 11756417 11884613 12402042 12676992 12743597 14672622 14684737 14699081 14762718 15024076 15059920 15199147 15240700 15312748 15369676 15379897 15545625 16110315 16126909 16127144 16517405 16517406 16585195 16782875 16888645 17143338 17418790 17533374 17785433 18054315 18056423 18158893 18718909 19211554 20028863 20427344 20535745 20855962 21051947 21765015 22006996 22841746 22850421 22988108 24006507 25043024 25103413 25732824 7493931 7500013 7508926 8089148 8702901 8955077 9486205 9525945 9707622
HIF1A EGLN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 23487784 12839937 22075993 20574527 15563275 19628018 18072750 24558194 22451659 16157596
HIF1A EGLN1 â—¼   OXIDOREDUCTASE_ACTIVITY_ELECTRON_TRANSFER ✅ 16.0 1.0 Reactome 11292861 15652751 17182618 12615973 12788921 11598268 11292862 21335549 17434750 15474027 15247232 12351678 12912907 15987702 22286099 18337469
EGLN1 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 32.0 1.0 Omnipath 19604478 20840591 16511565 23413029 12351678 15474027 22946054 15652751 16407130 25361009 31763849 32755251 16391536 15721254 20724477 24145445 17353276 18264140 26611735
HIF1A EGLN3 â—¼   ENZYMATIC_REACTION ✅ 66.0 1.0 ACSN 10102273 10428030 10428780 10435632 10804084 10823814 11557773 11559532 11744734 11756417 11884613 12402042 12676992 12743597 14672622 14684737 14699081 14762718 15024076 15059920 15199147 15240700 15312748 15369676 15379897 15545625 16110315 16126909 16127144 16517405 16517406 16585195 16782875 16888645 17143338 17418790 17533374 17785433 18054315 18056423 18158893 18718909 19211554 20028863 20427344 20535745 20855962 21051947 21765015 22006996 22841746 22850421 22988108 24006507 25043024 25103413 25732824 7493931 7500013 7508926 8089148 8702901 8955077 9486205 9525945 9707622
HIF1A EGLN3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19828020 15156561 20727020 15823097 22555025
HIF1A EGLN3 â—¼   OXIDOREDUCTASE_ACTIVITY_ELECTRON_TRANSFER ✅ 16.0 1.0 Reactome 11292861 15652751 17182618 12615973 12788921 11598268 11292862 21335549 17434750 15474027 15247232 12351678 12912907 15987702 22286099 18337469
EGLN3 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 17145710 15652751 26972000 15721254 16391536 16511565 24990963 12351678 31515488 24145445 17353276 15474027
SHH ERLEC1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 19002207 18502753 18711132 19346256 18264092 21357747 23867461 23719536
VCP ERLEC1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 19002207 21357747 18502753 18711132 18264092 23867461
HSPA5 ERN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 18624755 26551274 31226023 12637535
ESR1 IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17170218 20021813 16087727 19250214 10982795 24281069 18414489 15595626
HIF1A FOXM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22831955 19097132
RBX1 HIF1A â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 11292861 9122164 10878807 12821933 12101228 11292862 10823831 11504942 11454738 10944113 11358837 11024059
TCEB2 HIF1A â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
TCEB1 HIF1A â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
VHL HIF1A â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
RBX1 HIF1A â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
HIF1A VHL â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 12205091 15930297 21887475 22150821 22396654 15962286 23159849 17482131 17140440 16883594
HIF1A HSP90B1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19828020 15620698
VHL HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 123.0 1.0 Omnipath 17145710 21332579 24857547 12682018 26496610 11292861 11024059 15060148 16278378 12586829 17353276 12004076 12205091 17339318 10823831 11226425 21602890 16862177 15611064 12351678 16140212 11865071 26037477 16611863 10973499 23401859 25361009 11331613 18305400 25438054 14691445 17047048 12538644 22932900 18985005 26735336 21358672 18323857 10878807 19147576 16511565 17973296 23413029 24316222 11986208 12808024 12464182 23318261 22369643 19940151 15721254 20724477 21335603 16391536 23387829 18694926 26743088 14556007 18264140 10353251 15082527 11358837 11292862 11566883 12050673 19123984 17558023 27281823 15805242 11641274 25500545 34174286 24899725 12606543 32535973 17132228 24015760 12086861 11504942 35589690 26215701 22351759 12925778 18222538 17986458 14600153 10944113 23580587 26611735 18426857 20049704
OS9 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15652751 15721254 12351678 21118962
VCP OS9 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 19002207 21357747 18502753 18711132 18264092 23867461
OS9 SHH â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 19002207 18502753 18711132 19346256 18264092 21357747 23867461 23719536
VCP RBX1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 33444648 11733065 28115426 15652483 10811609 29153394
RBX1 TCEB2 â—¼   PHYSICAL_INTERACTION 21.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18420585 18931676 18985005 19622404 19622774 19686080 19809470 19847258
RBX1 VHL â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
RBX1 TCEB1 â—¼   PHYSICAL_INTERACTION 21.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18420585 18931676 18985005 19622404 19622774 19686080 19809470 19847258
RBX1 VHL â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
RBX1 TCEB1 â—¼   SHARES_COMPLEX 21.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18420585 18931676 18985005 19622404 19622774 19686080 19809470 19847258
RBX1 TCEB2 â—¼   SHARES_COMPLEX 21.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18420585 18931676 18985005 19622404 19622774 19686080 19809470 19847258
SHH SEL1L â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 19002207 21357747 18502753 18711132 18264092 23867461
SYVN1 SEL1L â—¼   PHYSICAL_INTERACTION 5.0 1.0 ACSN 12847084 16186509 18199748 18360008 19509052
SYVN1 SEL1L â—¼   SHARES_COMPLEX 5.0 1.0 ACSN 12847084 16186509 18199748 18360008 19509052
VCP SHH â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 19002207 21357747 18502753 18711132 18264092 23867461
TCEB2 TCEB1 â—¼   PHYSICAL_INTERACTION 21.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18420585 18931676 18985005 19622404 19622774 19686080 19809470 19847258
TCEB1 VHL â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
TCEB2 TCEB1 â—¼   SHARES_COMPLEX 21.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18420585 18931676 18985005 19622404 19622774 19686080 19809470 19847258
TCEB1 VHL â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
TCEB2 VHL â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
TCEB2 VHL â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258