Protein list:

Seperate proteins by space | Example

Select nodes using shift click or drag to add to this list
Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

Note this may take some time with > 30 proteins
Filter Graph:

0.5
Layout:
  🔂

Click a node or edge for more data...
Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
SPRR2D USP13 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
L1RE1 USP13 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
RAD23A ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
USP13 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
VCP ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16525503 5218414
BECN1 USP13 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 21962518 22216260
SIAH2 CACYBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5214111 11389839
CTNNB1 MITF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17000761 15729346
UBC CYLD â—¼   DEUBIQUITINATION ✅ 2.0 0.8 intact 19373254 7288828
NLRP3 DLST â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
EPCAM DLST â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
DVL1 USP13 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
VCP FAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18711132 0805371105
VCP FAF2 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
FAF2 VCP â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
FNBP1L USP13 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
FUNDC2 USP13 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
STAT1 HSPA4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9880553 10440232
LAPTM5 USP13 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
STAT1 MDC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15784679
MRPL20 USP13 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
TARDBP MYC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MYC TRIM63 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 31391242 233395
MYC TRIM55 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 31391242 233395
STAT1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10637230
MYO15A USP13 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
NEDD8 TRIM63 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 31391242 233395
PTEN USP13 â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 26280536 24270891
SMAD4 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8308197 22045334
ZEB1 SMAD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21421563
SMAD4 SNAI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18618014 18832382
UBC SNAI1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7718905 20385133
SNAI1 ZEB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21317430 12161443
USP13 TARDBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TOPBP1 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18923429 7296625
USP13 TRIM55 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 31391242 233395
USP13 TRIM63 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 31391242 233395
UBC USP5 â—¼   DEUBIQUITINATION ✅ 2.0 0.8 intact 19373254 7288828
UBC USP5 â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 26235645 7851534
USP10 USP13 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 21962518 22216260
CYLD UBC â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
NPLOC4 UFD1 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 20414249 7903886
MDC1 UIMC1 â—¼   PHYSICAL_INTERACTION 817.0 0.81 STRING 36370105
HNRNPM TARDBP â—¼   CORRELATES + 0.81 0.81 CCLE 31978347
MYC UFD1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30415952 29467282
FAF2 UFD1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26389662 18775313
DVL1 SMAD4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 12650946
MYC FAF2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 21150319 29467282
MYC SMC3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 29467282 17353931
MYC SMC1A â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 29467282 17353931
NPLOC4 UFD1L â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
UBL4A GET4 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 19615732 23246001 26186194 28514442
PTEN USP13 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
STAG1 STAG2 â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
SMAD4 SKP2 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 15314162 16865698
FAF2 UBL4A â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
MDC1 TOPBP1 â—¼   PHYSICAL_INTERACTION 855.0 0.85 STRING 36370105
EPCAM SPINT1 â—¼   CORRELATES + 0.85 0.85 CCLE 31978347
UBC UBQLN2 â—¼   PHYSICAL_INTERACTION 857.0 0.85 STRING 36370105
MYC PDS5A â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 29467282 17353931
CACYBP CTNNB1 â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
USP5 UBC â—¼   CLEAVAGE ✅ + 0.86 0.86 Signor 26235645
UBL4A FAF2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 19615732 23665563 23246001
FZR1 SKP2 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
MYC UBC â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 21150319 16996503 19131971
SMC3 PDS5A â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 17349791 26344197 31010829 19906707 15855230 21111234 17113138
G3BP1 PABPC1 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
MYC SKP2 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
AMFR BAG6 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
SMC1A WAPAL â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
ATXN3 RAD23A â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
MCL1 BECN1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 21139567 22219388 17446862
STAG1 WAPAL â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
STAG2 WAPAL â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
UIMC1 MDC1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 21622030 24240613 21857162 29656893 22990118
STAG2 SMC1A â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 17112726 10931856 29867216 26344197 24981860 26496610 23242214 31010829 19629043 29263825 17113138
RAD21 WAPAL â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
MDC1 TOPBP1 â—¼   KO_UP_REGULATES ✅ + 0.89 0.89 PKG 28854368
ITCH UBC â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
SMC3 WAPAL â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
AMFR FAF2 â—¼   PHYSICAL_INTERACTION 899.0 0.89 STRING 36370105
PDS5A WAPAL â—¼   PHYSICAL_INTERACTION 899.0 0.89 STRING 36370105
UBL4A BAG6 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 25713138 26344197 19615732 24981174 21636303 24581120 26496610 23246001 20676083 28514442 25535373
MYC FASN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14519204 12695333
VCP NPLOC4 â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 20414249 7903886
STAG1 RAD21 â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 17962804 6178082
STAG1 SMC1A â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 17112726 10931856 29867216 26344197 26496610 31010829 11076961 31807710 17113138
STAG1 SMC3 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 17349791 17112726 10931856 29867216 26344197 26496610 31010829 17962804 11076961 22885700 15855230 17113138
STAG2 STAG1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 29867216 24981860 31010829 17962804 11076961 30021884
GET4 UBL4A â—¼   PHYSICAL_INTERACTION 903.0 0.9 STRING 36370105
PDS5A STAG2 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
SMC1A SMC3 â—¼   CORRELATES + 0.91 0.91 CCLE 31978347
NEDD8 UBC â—¼   PHYSICAL_INTERACTION 925.0 0.92 STRING 36370105
AMFR VCP â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
UBC VCP â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
NPLOC4 UBC â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
STAG2 SMC3 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 17962804 6178082
PDS5A SMC1A â—¼   PHYSICAL_INTERACTION 959.0 0.95 STRING 36370105
STAG2 RAD21 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 17962804 6178082
PDS5A RAD21 â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
SMC1A STAG2 â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
SMC3 SMC1A â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 24981860 22939629 26496610 31807710 30021884 21880767 17112726 10931856 26344197 11590136 12759374 17349791 9789013 23242214 11877376 18832153 27173435 31010829 11076961 22885700 21111234 17113138
DLST OGDH â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
FAF2 VCP â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
PDS5A SMC3 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
SMC3 STAG2 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
BAG6 GET4 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
G3BP1 USP10 â—¼   PHYSICAL_INTERACTION 979.0 0.97 STRING 36370105
AMFR UBC â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
BAG6 UBL4A â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
ATXN3 VCP â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
ATXN3 UBC â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
UBC UIMC1 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
UBC USP5 â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
RAD23A UBC â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
SMC1A STAG1 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
SMC3 STAG1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
UFD1L VCP â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RAD21 SMC1A â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RAD21 SMC3 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RAD21 STAG2 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
NPLOC4 UFD1L â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
NPLOC4 VCP â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
RAD21 STAG1 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
SMC1A SMC3 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
VCP UFD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 23443559 16234241 26389662 16525503 18775313 26712280 27913212 15371428 20414249 26549226 16822850 18199748 23333620 17872946 19275885 24248593 20442859 27226613
NPLOC4 UFD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 16322459 18775313 18586029 15371428 20414249 26389662 36087575 32296183 17202270 24248593 20442859 11574150
AMFR VCP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 20126661 22328510 16407162 16987818 17681147 26712280 16275660 21636303 17872946 18835813 19828134 22119785 23333620 23383273 26424800 21343306 21914798 16186510 15331598 17311810
MYC AURKA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20890087 20519624 14744757 20682043
MCL1 BECN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 21353614 17446862 21139567
CTNNB1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 21533051 19778454 16510874 12095419 17360646 18852287 15576399 19561604 20300972 19662654 15579438 17724465 9727977 24447505 18679417 12907606
DVL1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 25241761 10806215 20006983 15735151
CTNNB1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 19751508 7542250 11967263 22290435 19623618 16574648 23343194 11955436 22270359 22761862 16039586 15810077 17143292 12051714 8666229 22943793 15576399 21151179 16940750 17306568 17666529 21285352 19619488
MYC HSPA4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 1534087 14519204 1562593 10446203
SMAD4 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11689553 17132729
MYC SKP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 24259667 12963825 12769844 23792459 21245140 24177224 23277542
MYC TXN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16099847 12695333
MYC PTEN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23135913 19578399 12695333
SKP2 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 17145710 24259667 12963825 12769844 17157259 23277542 20852628 16376880 35260179 26038816
VCP NPLOC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 34262183 31623962 20442859 32814053
SNAI1 PTEN â—¼   DOWN_REGULATES ✅ - 66.0 1.0 ACSN 10048576 11283614 11708773 12490555 12545156 12668723 14623871 14673164 15111329 15151915 15155580 15181457 15448698 15459715 16001073 16079281 16232121 16510505 16556862 16617148 16716598 16831886 17018611 17055429 17093497 17403902 17490644 17537911 17550342 17563753 17615296 17671186 18172008 18297062 18832382 19208835 19412634 19564415 19597490 19935649 20027199 20702634 20706219 20713526 20731704 21041997 21051859 21159887 21199805 21317430 21577210 21685935 21883379 2191300 22006115 22286765 22406545 22439866 22514743 22796940 22945800 23140366 23869868 8844971 9157999 9618481
STAG2 RAD21 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17145710 28430577 12034751 11590136 25173175 22885700 29263825
SMAD4 ZEB1 â—¼   PHYSICAL_INTERACTION 36.0 1.0 ACSN 11074002 11279127 11792802 12490555 12702545 12743038 12809600 14623871 15265520 16510505 16617148 16713975 16831886 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18832382 19208835 19412634 19839049 20519943 20731704 21199805 21224848 21317430 21614932 21883379 22006115 22406545 225147423 22945800 9389648
SMAD4 SNAI1 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16179589 16510505 16617148 16713975 16831886 17018611 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18768831 18832382 19208835 19412634 19597490 20731704 21041997 21042762 21199805 21317430 21577210 21614932 21883379 22006115 22331441 22406545 22514743 22945800 8515656 9389648
SMAD4 ZEB1 â—¼   SHARES_COMPLEX 36.0 1.0 ACSN 11074002 11279127 11792802 12490555 12702545 12743038 12809600 14623871 15265520 16510505 16617148 16713975 16831886 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18832382 19208835 19412634 19839049 20519943 20731704 21199805 21224848 21317430 21614932 21883379 22006115 22406545 225147423 22945800 9389648
SMAD4 SNAI1 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16179589 16510505 16617148 16713975 16831886 17018611 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18768831 18832382 19208835 19412634 19597490 20731704 21041997 21042762 21199805 21317430 21577210 21614932 21883379 22006115 22331441 22406545 22514743 22945800 8515656 9389648
SMAD4 ZEB1 â—¼   UP_REGULATES ✅ + 36.0 1.0 ACSN 11074002 11279127 11792802 12490555 12702545 12743038 12809600 14623871 15265520 16510505 16617148 16713975 16831886 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18832382 19208835 19412634 19839049 20519943 20731704 21199805 21224848 21317430 21614932 21883379 22006115 22406545 225147423 22945800 9389648
SMAD4 SNAI1 â—¼   UP_REGULATES ✅ + 41.0 1.0 ACSN 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16179589 16510505 16617148 16713975 16831886 17018611 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18768831 18832382 19208835 19412634 19597490 20731704 21041997 21042762 21199805 21317430 21577210 21614932 21883379 22006115 22331441 22406545 22514743 22945800 8515656 9389648
SNAI1 ZEB1 â—¼   UP_REGULATES ✅ + 66.0 1.0 ACSN 10048576 11283614 11708773 12490555 12545156 12668723 14623871 14673164 15111329 15151915 15155580 15181457 15448698 15459715 16001073 16079281 16232121 16510505 16556862 16617148 16716598 16831886 17018611 17055429 17093497 17403902 17490644 17537911 17550342 17563753 17615296 17671186 18172008 18297062 18832382 19208835 19412634 19564415 19597490 19935649 20027199 20702634 20706219 20713526 20731704 21041997 21051859 21159887 21199805 21317430 21577210 21685935 21883379 2191300 22006115 22286765 22406545 22439866 22514743 22796940 22945800 23140366 23869868 8844971 9157999 9618481
USP5 UBC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 19285159 20622874 22878415 26235645 18482987 19373254 16007098 31663737 25970461 27848959 17550899 26876099 24681967 23314748 17980597 16564012 27066941 17692280 22428841 8841133 22216260 24424410 34648286
MDC1 CDA â—¼   KO_DOWN_REGULATES ✅ - -2.82 2.81 PKG 28854368
MDC1 MDC1 â—¼   KO_DOWN_REGULATES ✅ - -3.38 3.37 PKG 28854368
PMS1 PMS1 â—¼   KO_DOWN_REGULATES ✅ - -7.89 7.88 PKG 28854368