Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
CHEK2 UBE2V2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 19001859 12364621
CHEK2 UBE2N â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 19001859 12364621
CHEK2 KAT5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 19001859 12364621
CHEK2 KAT5 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 16651405 10724175
CHEK2 UBE2V2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 16651405 10724175
CHEK2 UBE2N â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 16651405 10724175
HIF1A EGLN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218395 16511565
EGLN3 HIF1A â—¼   HYDROXYLATION ✅ 2.0 0.8 intact 5217229 15474027
EP300 HIPK2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 18695000 16917507
ESR1 EP300 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16704985 11279135
HIPK2 EP300 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 16917507 5218981
EP300 CCNT1 â—¼   ACETYLATION ✅ 2.0 0.8 intact 7265510 19387490
SKI EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17469184 10575014
UBE2D2 KAT5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
UBE2I KAT5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
KAT5 PIAS3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
KAT5 AR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10364196 5211544
PML MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15273249 16189514
MAPK14 SIAH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17003045
MAPK14 PIAS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16713578
PML STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12506013 16189514
STAT3 MYD88 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7567467 12244150
TPX2 DLST â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
UBE2N UBE2I â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22661230 22635276
UBE2I UBE2V2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22661230 22635276
SIAH1 ATN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
SIAH2 ATN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
VAV1 VAV2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9705280 11804587
HSPA5 TRAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
SPRY2 TRAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
HDAC3 SKI â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 12435627 19032343
AR NCOR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19351840 20610535
SIAH2 TINF2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 22064479 22634377
SIAH2 POT1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 22064479 22634377
SIAH2 RAP1A â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 22064479 22634377
RAP1A PLCE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11022048 12444546
SIAH2 TERF2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 22064479 22634377
ESR1 NFE2L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 24641954 20623181
USP19 HIF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22128162 21849505
HIF1A EGLN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218395 16511565
EGLN1 HIF1A â—¼   ENZYMATIC_REACTION ✅ 0.8 0.8 mint 7987706 20840591
HIF1A CD274 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24778419 27141364
EGLN1 HIF1A â—¼   HYDROXYLATION ✅ 2.0 0.8 intact 5217229 15474027
HIF1A EGLN2 â—¼   HYDROXYLATION ✅ 2.0 0.8 intact 5217229 15474027
HIF1A EGLN1 â—¼   HYDROXYLATION ✅ 0.8 0.8 mint 5217229 15474027
HIPK3 SIAH2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SIAH2 CACYBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5214111 11389839
SIAH2 TPP1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 22064479 22634377
ESR1 SIAH2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18414489 16141343
SIAH2 SNCAIP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16174773 15064394
AR CEBPD â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24810056 20610535
SNCA PIAS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
AR LATS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15131260 20610535
ESR1 EGLN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18414489 11850811
AR HSPA5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20610535 21125667
AR PEG10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20610535 17369855
SIAH1 HIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
HIPK3 ZYX â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SH3R1 SIAH1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 16230351
SIAH1 STAT3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 27871173 21988832
ESR1 RAP1A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19805454 31527615
PRIC3 SIAH2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
SIAH2 UBP19 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22128162 23500468
AFF1 CCNT1 â—¼   PHYSICAL_INTERACTION 819.0 0.82 STRING 36370105
KAT5 STAT3 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 12551922 16713569
TYK2 VAV â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 10673353 16189514
HIPK2 UBE2I â—¼   PHYSICAL_INTERACTION 831.0 0.83 STRING 36370105
HIPK2 SIAH1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
HIPK2 PML â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
PIAS2 TRAF2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 32296183 22184250
HIF1A STAT3 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
HIF1A KAT2B â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
HDAC3 STAT3 â—¼   PHYSICAL_INTERACTION 845.0 0.84 STRING 36370105
STAT3 HIF1A â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 15735682 18985005 23604114 23991099
SIAH2 TRAF2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 12411493 16713569
SIAH2 SNCA â—¼   PHYSICAL_INTERACTION 849.0 0.85 STRING 36370105
LATS2 LATS1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 33961781 24255178 34079125 32707033 21233212
TP53BP2 PPP1CC â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 21998301 270751 8217559
SIAH1 SNCA â—¼   PHYSICAL_INTERACTION 849.0 0.85 STRING 36370105
EGLN3 SIAH2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 25202994 16958618 15210114
EP300 STAT3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 10205054 15653507 16713569 33531691 26504087 18782771 30110629 11923478 15735682 15649887 33742100 22116549
HIPK2 SIAH1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 19043406 19250734 23503458 33591310 18536714
KAT2B HIF1A â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 22908229 21148070 20620956 16543236
ESR1 STAT3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 23874500 11429412
MYD88 SIAH1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 32117091 21988832
HDAC3 ESR1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 31527615 16469706 14722073 26487511 20348541
SH3R1 SIAH2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 21586138 25438054
SIAH2 PEG3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16713569 10681424
ESR1 CCNT1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 15940264 31527615
SIAH1 PEG3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16713569 10681424
SIAH1 UBE2D3 â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
SIAH1 UBE2D1 â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
SIAH2 UBE2D2 â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
HDAC3 HIF1A â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 17273746 11641274
SIAH1 SIAH2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 33961781 26186194 16899216
SIAH2 LATS2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 27030211 25438054
PIAS1 ESR1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 11117529 15666801 31527615
PEG10 SIAH1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 12810624 25416956
SIAH1 SIAH2 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
EP300 STAT3 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
HIF1A EGLN3 â—¼   HYDROXYLATION ✅ 0.88 0.88 mint 5217229 15474027
STAT3 PML â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 12506013 16189514
PML HDAC3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16189514 11259576
PIAS3 STAT3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16189514 11429412 21988832 9724754 18037959 12804609 20516148
EGLN2 HIF1A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11292861 26644182 11292862 16511565 15474027 16155211 17353276 18264140
SIAH2 SYPH â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16713569 11786535
SIAH1 PIAS1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 17533377 27485016
AR EP300 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
EP300 KAT2B â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
KAT2B EP300 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 8684459 12888487 9267036 12419806 21413932 22384255 20870727 33051058
EP300 HIPK2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16917507 29170424
CCNT1 PML â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28555140 12727882
TRAF2 UBE2N â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 23453969 20047764 23007157 20577214 34117217 11057907 22184250
HDAC3 SKI â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17621263 16987993 19341714 19032343
SIAH2 PIAS1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17533377 27485016
SIAH2 VAV â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10207103 16713569
LATS1 ZYX â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10831611 16713569
AFF1 CCNT1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 20153263 21030982 27684187 19956800 24367103
UBP19 SIAH1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 27776223 33961781 22128162 23500468
SIAH1 SYPH â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16713569 11786535 25755825
SIAH1 DCC â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 31413325 9858595 16713569
TES ZYX â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 12695497 28378594
SNCA SNCAIP â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
TRAF2 UBE2N â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
PIAS3 STAT3 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
POT1 TINF2 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
ESR1 CCAR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21596782 20074560 17473282
CHEK2 TERF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 26799419 19375317
HIF1A EGLN3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25416956 18402654 18063574 16511565 15474027 31239290 24015760 17069766 17353276 16155211 30067985 26972000 23345396 15721254 18264140
EP300 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19887647 11782371 12738788 25728767 11867769 12479814 23065768 15308690 20388208 14761960 22227247 8799122 20348541 23403292 12714702 11581164 16713569 19838210 18765668 16645043 30418174 12574227
AR HMOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11965035 20610535
STAT3 HMOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20568122 19129475
ESR1 KAT5 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31527615 17418098 16260778 22081016 11591700
NCOR1 PML â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11430826 10882117 16713569
STAT3 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21546410
UBE2L6 UBE2N â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16112642 16428300 16122702
UBE2N TRAF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18981220 14713952
DYRK2 SIAH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22878263
NCOR1 SKI â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10049357 12764135 19032343 11430826 14525983
NCOR1 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16713569 24051437 12145334 16469706 17400812 12738788 21182203
TINF2 TERF2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 23307557 15316005 28514442 21044950 15383534 15181449 15231715 19287395 16880378 15292264 20811636 26496610 33961781
HIF1A EGLN1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 24681946 20724477 31763849 15721254 20812988 25974097 16407130 27563096 26611735 29279301 17069766 22946054 15474027 20840591 17442832 33550096 23413029 18264140 25361009 18063574 16511565 34007068 16155211 19604478 17353276
AR PIAS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20610535 18656483 10628744
SIAH1 SNCAIP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16174773 15064394 14506261
PML UBE2I â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
PPP1CC PPP1R13B â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
PPP1CC TP53BP2 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
AR NCOR1 â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
EGLN2 HIF1A â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
EGLN3 HIF1A â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
EP300 ESR1 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
EGLN1 HIF1A â—¼   PHYSICAL_INTERACTION 935.0 0.93 STRING 36370105
HIF1A EP300 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 17382325 5219810
PIAS2 UBE2I â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
PIAS1 UBE2I â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
SIAH1 USP19 â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
HIF1A EP300 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15280364 19589782 16543236 11823643 22807441 19666581 16189267 18047470 15342390 12042299 19680224 22735262 23448368 26135796 23618863 14691445 19696166 11959990 27320910 16847340 24821806 22789427 17906695 8917528 20620956 20000859 15261140 16081065 12778114 22219185 15154850 25192544 22075993 19071119 22908229 19940151 21187066 24421387 23880760 11940656 23966271 26826385 26944191 12588875 23746844 11063749 27808477 19074848 20603618 15155277 18268343 20829524 21148070 12914934 17502379 22684029 17382325 26751287
HDAC3 NCOR1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 16917504 11466315 10944117 21258344 11509652 16195251 16469706 14722073 15601853 12628926 11931768 11804585 14527417 16980585 23752268 29523594 16713569 10860984 11013263
DLST OGDH â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
CACYBP SIAH1 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
TERF2 TINF2 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
DCC NTN1 â—¼   PHYSICAL_INTERACTION 989.0 0.99 STRING 36370105
UBE2N UBE2V2 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
EP300 HIF1A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PLK3 CHEK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 21376736 10973490 16481012 17918214 12242661 25404613 16189514 11901158 12493754
UBE2D2 EGLN3 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
UBE2D1 EGLN3 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
UBE2D3 EGLN3 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
HIF1A EGLN3 â—¼   ENZYMATIC_REACTION ✅ 66.0 1.0 ACSN 10102273 10428030 10428780 10435632 10804084 10823814 11557773 11559532 11744734 11756417 11884613 12402042 12676992 12743597 14672622 14684737 14699081 14762718 15024076 15059920 15199147 15240700 15312748 15369676 15379897 15545625 16110315 16126909 16127144 16517405 16517406 16585195 16782875 16888645 17143338 17418790 17533374 17785433 18054315 18056423 18158893 18718909 19211554 20028863 20427344 20535745 20855962 21051947 21765015 22006996 22841746 22850421 22988108 24006507 25043024 25103413 25732824 7493931 7500013 7508926 8089148 8702901 8955077 9486205 9525945 9707622
HIF1A EGLN3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19828020 15156561 20727020 15823097 22555025
HIF1A EGLN3 â—¼   OXIDOREDUCTASE_ACTIVITY_ELECTRON_TRANSFER ✅ 16.0 1.0 Reactome 11292861 15652751 17182618 12615973 12788921 11598268 11292862 21335549 17434750 15474027 15247232 12351678 12912907 15987702 22286099 18337469
EGLN3 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 17145710 15652751 26972000 15721254 16391536 16511565 24990963 12351678 31515488 24145445 17353276 15474027
KAT2B EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8684459 14500836 9267036 17496784 20870727
EP300 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11971970 10779504 24480624 17011549 16713569
EP300 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 18782771 15509516 8756628 10205054 7530500 15653507 15735682 19506034 16285960 16713569 11322950 7499365 15649887 9590694
EP300 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 75.0 1.0 Omnipath 24821806 12573436 17145710 16847340 12588875 19589782 11940656 25192544 11959990 18519678 23448368 22219185 11823643 12042299 15342390 23746844 19071119 19680224 27808477 15154850 19696166 8917528 17906695 18268343 22735262 21148070 15261140 19940151 23880760 22807441 35430356 14691445 12914934 20000859 12778114 26751287 16081065 22789427 16543236 24421387 17382325 17502379 22684029 21187066 19074848 23618863 23966271 20603618
SIAH1 HIPK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 19043406 19788416 9403064 23503458 18536714 19250734 19607803 20682032 21466614
SIAH2 HIPK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 19788416 9403064 19607803 20682032 21466614
HIPK2 SKI â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 21071413 12874272 18988627
HIPK2 PML â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 17081983 27689990 27308327 26539288 19015637
NFE2L2 HMOX1 â—¼   ENZYMATIC_REACTION ✅ 14.0 1.0 ACSN 10441483 10821856 10874044 11279008 11909699 12356737 12511571 15521073 16219762 17512463 18761713 19027064 19747488 23850759
NFE2L2 HMOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 72.0 1.0 Omnipath 24211276 21382013 23000247 21908612 17942419 18381655 31257023 12745069 22107958 18586007 23904790 24434148 21622983 21808062 22245129 16951197 22370642 23571756 24844779 21658364 11274184 20083128 14747657 15870071 17313370 24759106 20558128 14688281 23525690 21597468 22541814 21443188 21635873 18704831 22521774 16407140 22793650 18006113 22459801 24035498 24140584 23413426 22901690 18771089 24755082 20345481 16551619 23294286 23046979 15122755 16945925 23347118 23738042 21037234 23479260 19056485 19679681 22484158 18202225 24024136 16480751 19931411 20402460 17408602 21982894 25337552 24503931 19454702 23826208 20643109 18567745
HIF1A HMOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 11592948 19828020 20819234 17389506 10600883 11356853 15805230 18799519 17122584 17996129 20526373 15050899 20833713 14970910 19254160
NFE2L2 HMOX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10874044 18241676 12356737 18535259 12511571 10821856
AR KAT2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18945670 20610535 11328859 23095762
KAT2B AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11971970 10779504
KAT5 RBBP8 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
PML KAT5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19150978
KAT5 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 12551922 16713569
KAT5 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11591700 10364196 19150978 11994312 16713569
MAPK14 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 23331499 10201984 18691976 17502367 17570479
MAPK14 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23216744 22431515 12138194 15879307
MAPK14 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 30644418 24424504 21820033 16282370
PLK3 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 18519666 20889502 26784107
PLK3 SNCA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 19889641 26120904 22828320 23677647 21849493 25009465
TYK2 STAT3 â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
STAT3 HIF1A â—¼   DOWN_REGULATES ✅ - 24.0 1.0 ACSN 10347215 10973499 12223527 14607900 14670306 15218058 15356132 15573129 16418395 18776941 18985005 19380816 20093776 20237412 20406969 20581311 21840487 23124025 23454751 23953057 24857661 27216177 28186502 7543512
STAT3 CD274 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19088198 21268011 27141364
STAT3 HIF1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19265129 18644974 16007214 20924113 17597020 23991099
STAT3 CEBPD â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10867011 17471507 24011072 15389878 15486993 9163525 25787076 15930175 9528783 16293640
TYK2 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 29145629 21098725 12626585 10542297 23331499 15261459 8662928 30910759 23673666 14565860 12023369 30029643 14764663 18389480 23124025 25516297
PIAS3 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 11709556 21988832 23331499 12804609 9388184 18037959 15138572 11429412 11266437 20516148 9724754 16189514 19569236
STAT3 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15735682 18985005 10973499
UBE2D3 HIF1A â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
UBE2D3 EGLN1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
AR UBE2D3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20610535
UBE2D1 HIF1A â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
UBE2D1 EGLN1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
HDAC3 NCOR1 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 11399519 11875494 15644117 16127449 17260466 17681149 17689680 21234400 23390297 6357187 8871614
HDAC3 NCOR1 â—¼   SHARES_COMPLEX 11.0 1.0 ACSN 11399519 11875494 15644117 16127449 17260466 17681149 17689680 21234400 23390297 6357187 8871614
NCOR1 HDAC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 11509652 11013263 16195251 11931768 16469706 21258344 17694085 10860984 16917504 10944117 23752268 16713569 14527417 11466315 11804585 12628926 15601853
AR NCOR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 15598662 11971970 16469706 14593076 15256534 23518348 16713569 12089345 16914745 20812024 20974212
NCOR1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 16469706 12738788 12145334 17400812 16713569 21182203
RAP1A TINF2 â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
TINF2 TPP1 â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
TINF2 POT1 â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
TINF2 TERF2 â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
RAP1A TINF2 â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
TINF2 TPP1 â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
TINF2 POT1 â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
TINF2 TERF2 â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
RAP1A POT1 â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
POT1 TERF2 â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
POT1 TPP1 â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
RAP1A POT1 â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
POT1 TERF2 â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
POT1 TPP1 â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
RAP1A TPP1 â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
RAP1A TERF2 â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
RAP1A TPP1 â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
RAP1A TERF2 â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
TERF2 TPP1 â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
TERF2 TPP1 â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
NTN1 DCC â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 11248093 11989976 17613518 17959595 19543238 19931333 20173780 20495383 22920895 26618107 9765224
NTN1 DCC â—¼   SHARES_COMPLEX 11.0 1.0 ACSN 11248093 11989976 17613518 17959595 19543238 19931333 20173780 20495383 22920895 26618107 9765224
NTN1 DCC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 19721007 8861902 26190107 9950216 11239160 25881791 10399920 12810718
NFE2L2 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 24466341 17640564 18588981 15655294 22951256
UBE2D2 HIF1A â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
HIF1A EGLN2 â—¼   ENZYMATIC_REACTION ✅ 66.0 1.0 ACSN 10102273 10428030 10428780 10435632 10804084 10823814 11557773 11559532 11744734 11756417 11884613 12402042 12676992 12743597 14672622 14684737 14699081 14762718 15024076 15059920 15199147 15240700 15312748 15369676 15379897 15545625 16110315 16126909 16127144 16517405 16517406 16585195 16782875 16888645 17143338 17418790 17533374 17785433 18054315 18056423 18158893 18718909 19211554 20028863 20427344 20535745 20855962 21051947 21765015 22006996 22841746 22850421 22988108 24006507 25043024 25103413 25732824 7493931 7500013 7508926 8089148 8702901 8955077 9486205 9525945 9707622
HIF1A EGLN1 â—¼   ENZYMATIC_REACTION ✅ 66.0 1.0 ACSN 10102273 10428030 10428780 10435632 10804084 10823814 11557773 11559532 11744734 11756417 11884613 12402042 12676992 12743597 14672622 14684737 14699081 14762718 15024076 15059920 15199147 15240700 15312748 15369676 15379897 15545625 16110315 16126909 16127144 16517405 16517406 16585195 16782875 16888645 17143338 17418790 17533374 17785433 18054315 18056423 18158893 18718909 19211554 20028863 20427344 20535745 20855962 21051947 21765015 22006996 22841746 22850421 22988108 24006507 25043024 25103413 25732824 7493931 7500013 7508926 8089148 8702901 8955077 9486205 9525945 9707622
HIF1A EGLN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 23487784 12839937 22075993 20574527 15563275 19628018 18072750 24558194 22451659 16157596
HIF1A EGLN1 â—¼   OXIDOREDUCTASE_ACTIVITY_ELECTRON_TRANSFER ✅ 16.0 1.0 Reactome 11292861 15652751 17182618 12615973 12788921 11598268 11292862 21335549 17434750 15474027 15247232 12351678 12912907 15987702 22286099 18337469
HIF1A EGLN2 â—¼   OXIDOREDUCTASE_ACTIVITY_ELECTRON_TRANSFER ✅ 11.0 1.0 Reactome 11292861 12615973 12788921 11598268 11292862 21335549 17434750 15474027 15247232 12351678 12912907
EGLN1 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 32.0 1.0 Omnipath 19604478 20840591 16511565 23413029 12351678 15474027 22946054 15652751 16407130 25361009 31763849 32755251 16391536 15721254 20724477 24145445 17353276 18264140 26611735
EGLN2 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 15652751 16391536 15721254 16511565 24990963 11292862 12351678 24145445 17353276 11292861 15474027
TNK2 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 17494760 17045208 22168167 26546517 21318111 22566699 23597703 28055971 25699576 25950519 25347744 23424109 20623637 31819114 20383201 26814148
AR UBE2I â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10383460 8798622 19692572 12764129
UBE2I AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10383460 8798622 19692572 12764129
PIAS1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15666801 11117529
ESR1 PSMD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18457947 9253789 12648521 11696545 23580568
LATS1 ZYX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10831611 16713569
ESR1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8299561 11000528 22391641
ESR1 NRF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18048642 21486948 23892277
AR ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 12389206 11032808 16713569 11000528 18988627
AR AKR1C3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 23579488 23995860 22971343
HIPK3 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9725910
PIAS2 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11117529 9920921 12177000 16713569 11477070 12764129
UBE2D2 EGLN1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499