Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
ANK3 SMAD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
ANK3 SMAD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
BAG3 DVL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
JUN BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16229810 17434164
EP300 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23353771 23285190
BRCA1 IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11001824 19223505
SMAD3 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19768112 15735739
BRCA1 SOX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15574597
DVL2 CSNK1E â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
CSNK1E CDH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20940130
HIF1A EGLN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218395 16511565
EGLN3 HIF1A â—¼   HYDROXYLATION ✅ 2.0 0.8 intact 5217229 15474027
EP300 BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20660371 19102934
EP300 RECQL4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19299466
JUN FBXW7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21460851 20638938
MYC FBXW7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20638938 19366810
TERF1 KDM1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23455924 8417751
MYC KDM1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23455924 8417751
KDM1A MALT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23455924 8417751
KDM1A SMN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23455924 8417751
HIF1A KDM1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 32938217
SNAI1 KDM1A â—¼   COLOCALIZATION 2.0 0.8 intact 7903691 20389281
MTOR RPS6KA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15060135
MYC FGFR3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ERG MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25277175 20820186
MYC GEMIN4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17353931 17093053
NUAK1 LATS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7717767 19927127
PTPN11 CD274 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18173375 18759926
PTPN11 JAK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 8766559
RUVBL1 RELB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
RUVBL1 CTNNB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18087039 0710343105
UBC SNAI1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7718905 20385133
SMAD2 SNAI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19389392 18618014
SMAD4 SNAI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18618014 18832382
HIF1A SNAI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23979441 23496980
MARCHF7 USP7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
USP7 RELB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
UBA52 USP7 â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 26235645 9521656
RPS27A USP7 â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 26235645 9521656
USP7 UBA52 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16713569 26235645
USP7 RPS27A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17145710 26235645
LATS2 YAP1 â—¼   PHOSPHORYLATION ✅ - 0.8 0.8 Signor 22658639
USP9X MARCHF7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18410486
SNRPB GEMIN4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10725331 5212337
GEMIN4 NFKB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
GEMIN4 MAP3K1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
GEMIN4 DDX20 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10725331 5212337
SMAD2 UBA52 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
UBA52 SNCA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
UBA52 USP9X â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 26235645 9521656
RPS27A HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RPS27A USP9X â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 26235645 9521656
IRS2 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11505033 15705774
SMAD4 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8308197 22045334
UBC SMAD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8308197 22045334
MAP3K1 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 10085121
SMAD2 NANOG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21402155
SMURF1 SMAD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD3 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8308197 22045334
SMAD3 SMN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20123992 21965288
SMAD3 GATA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 11790301
SMAD3 NANOG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21402155
HIF1A PTEN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18340011 19648120
MAST1 PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15951562
SMURF1 PRICKLE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19379695
FGFR3 JUN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
UBC JUN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7104155 19343052
HIF1A JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15794924 19828020
JUN ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21384344 16786139
JUN NFKB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7541912
HTT BIRC5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SNCA BIRC5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CUL3 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NFE2L2 CUL3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21793854 20452971
USP9X RELB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HDAC6 RELB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
RELB NFKB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
CTNNB1 CDH1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12640114 5216233
GATA3 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20189993
PRKD1 CDH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15695390
MAP3K5 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MAP2K3 MAP3K5 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15866172 8974401
HNRNPM MAP3K1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
USP9X MAP3K1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
IRS4 MAP3K1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
MAP3K1 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218828 16845370
PRKD1 MAP3K1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 17496911 17703233
EIF4B RPS6KA1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5218723 16763566
EIF4B DDX3X â—¼   COLOCALIZATION 2.0 0.8 intact 8407815 22872150
LRRK2 LATS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
LRRK2 MAP2K3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19302196
FGFR3 DVL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
VHL HIF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218395 16511565
HIF1A HDAC5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19071119 6802010
HIF1A FLT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16601206 15192019
HIF1A BIRC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19828020 17043658
HIF1A CD274 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24778419 27141364
CTNNB1 IRS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15592430 12782598
IRS1 IRS4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 11912194
IRS2 IGF1R â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8662806 5221055
IGF1R GRB10 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6547677 9506989
VHL IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17486080 19509240
FGFR3 GATA3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HNRNPM USP9X â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
USP9X NFKB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
CTNNB1 VHL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16983094 0606850103
BIRC3 BIRC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23070005 18485876
IRAK1 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218906 16884718
SMAD1 GATA3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22219353
HDAC6 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
DDX20 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CEP55 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HTT UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SNCA HTT â—¼   COLOCALIZATION 2.0 0.8 intact 22119730 8292239
HTT MAP3K10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16713569 10801775
WWP1 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7104155 19343052
ZRANB1 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19373254 7288828
UBC PHB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7717349 20134482
UBC RCHY1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5220017 17568776
UBC NFKB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18617892 6804701
UBC ZRANB1 â—¼   DEUBIQUITINATION ✅ 2.0 0.8 intact 19373254 7288828
HDAC5 GATA3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0607926103 17075044
CTNNB1 NANOG â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 32448362 25921273
CTNNB1 SOX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 24291232 24482235
ERBB2 IRS4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
DDX3X NFKB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
NFKB2 HNRNPM â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
GATA3 ERG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21536859
HNRNPM MAST1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
PBX1 NANOG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19522013
PBX1 NANOG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19522013
SOX2 NANOG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17211451
GEMIN5 SMN1 â—¼   COLOCALIZATION 2.0 0.8 intact 5214807 11714716
PTEN USP7 â—¼   PHYSICAL_INTERACTION 806.0 0.8 STRING 36370105
SMN1 SNRPB â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
BRCA1 SMAD3 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 19768112 15735739
IRS1 RPTOR â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 16354680 19561084 30240640
PTEN WWP1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 33470109 21532586 25547115
ITCH RPS27A â—¼   PHYSICAL_INTERACTION 810.0 0.81 STRING 36370105
LATS2 SAV1 â—¼   PHYSICAL_INTERACTION 811.0 0.81 STRING 36370105
LATS1 YAP1 â—¼   PHOSPHORYLATION ✅ - 0.81 0.81 Signor 22658639
CFTR BAG3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 26618866 31324722
BRCA1 KDM1A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22990118 26831064
ERG EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 35140242 28536097
HDAC6 EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19344692 15102857 12718889 22778253 23133622
HUWE1 USP9X â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 20023629 21907705
SOX2 KDM1A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30442713 28794006
MYC RPS27A â—¼   PHYSICAL_INTERACTION 819.0 0.82 STRING 36370105
MYC MIB1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21150319 29467282
MYC JUN â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21150319 20232342
SHC1 ERBB2 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 16729043 5218694
USP9X SMAD4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28115363 19135894
CTNB1 PTEN â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 20372837 20123964
AXIN1 USP9X â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22682247 17510365
IGF1R CTNB1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 27684187 22261717
IGF1R ERBB2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17307140 30898150
RHOB PAK4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
U5S1 USP9X â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28515276 22939629
CFTR USP9X â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31324722 17110338
SUV91 USP9X â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
ZN263 USP9X â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
UNK USP9X â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22939629 25737280
ZN408 USP9X â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
HEXI2 USP9X â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
MIB1 USP9X â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31462741 24239288
SUV3 USP9X â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
BIRC3 USP9X â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23524849 30948266
RHOB MINK1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
SAV1 AMOT â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30266805 24255178
LATS2 AFAD â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 24255178
NFKB2 UBC â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 14743216 18617892
RHOB CEP55 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
NFX1 DDX3X â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 29395067 31059266
TDRD3 DDX3X â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 18632687 29395067
RHOB IRS4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
SOX2 CTNB1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23539445 23667531
ZN263 NFX1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
USP9X YAP1 â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
HUWE1 RPS27A â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
RPTOR UNK â—¼   PHYSICAL_INTERACTION 827.0 0.82 STRING 36370105
RPTOR BAG3 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
BRCA1 TERF1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 34112789 19797051 29656893
BRCA1 TERF2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 34112789 25184681 19797051 29656893
CTNB1 EP300 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 15572674 33742100 15806138 26123998 33190089 11050151 32603375 30986748 15060161 30836930 26657156 12408825
USP9X YAP1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 22939629 26598551 29449692
BIRC2 BCL10 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16775419 33961781 10753917
SMAD4 JUN â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 10220381 25609649
SMAD3 WWP1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 32296183 25416956 25910212 15221015 15359284
FLT1 FLT4 â—¼   PHYSICAL_INTERACTION 829.0 0.83 STRING 36370105
PEG10 USP9X â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
SOX2 USP9X â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 23667531 31605775
HDAC6 CFTR â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 31501480 22069321 14675537
PEG10 IQCB1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
EP300 VHL â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CTNNB1 SMAD3 â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
NANOG SOX2 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
SNAI1 EP300 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28296173 25314079 32494626
MYC HIF1A â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28628118 15071503 28205554
CUL3 PEF1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 27716508 21145461
BCL10 BIRC3 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
SMAD2 CTNB1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 12000714 23246962 20571128 27684187
SMAD1 SMAD3 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 9111321 15761153 18729074
SMAD3 CTNB1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 12000714 22241478 20571128 21965288 27684187
CLK3 USP9X â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 32707033 23602568
KC1E USP9X â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 32707033 23455922
LATS2 CTNB1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 24360964 24255178
LATS2 AMOT â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 24225952 24101513 24106267 24255178 30266805
HDAC6 CTNB1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 18356165 23084749
PTPN11 ERBB2 â—¼   DEPHOSPHORYLATION ✅ - 0.84 0.84 Signor 32024694
IRAK1 MAP3K7 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
FBXW7 MCL1 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
HUWE1 UBA52 â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
CTNNB1 RUVBL1 â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
DDX20 GEMIN8 â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
ARRDC3 UBA52 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HuRI 32296183
EP300 SMAD1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 10205054 20851880 22365546 16613856 10673036
LATS2 SNAI1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 24157836 21952048
HIF1A JUN â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 25879517 19738058 11739718
LRRK2 PAK6 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 24510904 24947832 26375402
PAK4 PAK6 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 28514442 32707033 33961781 26186194
LATS2 USP9X â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 32707033 29183995 28720576 24255178
LATS2 LATS1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 33961781 24255178 34079125 32707033 21233212
RPS27A ZRANB1 â—¼   PHYSICAL_INTERACTION 853.0 0.85 STRING 36370105
IGF1R IRS1 â—¼   PHOSPHORYLATION ✅ + 0.85 0.85 Signor 17827393
HDAC6 RPS27A â—¼   PHYSICAL_INTERACTION 857.0 0.85 STRING 36370105
AMOT BAG3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 19615732 25036637
SMAD4 EP300 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9679056 25514493 18215124 9843571 14612423 10887155 22033265
EP300 SMAD3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9679056 15824515 15688032 16109717 15345715 20564330 9843571 15133024 10497242 17469184 15623506 10575014 15588252 18055455 16876108 21567395 11134049 12743039 11058129
MYC HUWE1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 17314511 16269333 26279298 18488021 29467282 31677785
MYC IRS4 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 17314511 30415952
YAP1 AXIN1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 24976009 29789528
BIRC3 BCL10 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 10753917 16395405 33961781 11466612 16775419
LRRK2 DVL2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 31046837 19625296
LATS1 ITCH â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 21212414 24107629 23564455 28416659 34079125 21383157
KC1E SAV1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 23455922 24255178
HDAC6 ERBB2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 20029029 31980649
PCM1 CEP55 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 34079125 26638075
ARRDC3 PRKAA2 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HuRI 32296183
GEMIN4 GEMIN5 â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
SMN2 SNRPB â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
ITCH LATS1 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
MYC EP300 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15616592 16287840 32140074 16126174 17157259 12776737
MYC KDM1A â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 32296183 30415952 29467282 23455924
MYC DDX20 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 17353931 17314511 29467282
MYC UBC â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 21150319 16996503 19131971
ITCH JUN â—¼   PHYSICAL_INTERACTION 869.0 0.87 STRING 36370105
ITCH JUN â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 17110928 16901904 19818398 19806201
HMGA1 JUN â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 10357819 10428834
CTNB1 HIF1A â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 22865883 23246962 24650032 17220880 23671189
GRB10 IRS1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 8621530 12783867
KC1E PCM1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 34079125 23455922 26496610 26638075
KDM1A SNAI1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
UBA52 USP7 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
DDX20 GEMIN4 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
DDX20 GEMIN5 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CEP290 IQCB1 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
PARK2 SNCA â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
BRCA1 MYC â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
UBA52 UBE2D1 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
GEMIN5 SMN1 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
AMOTL2 YAP1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
GEMIN4 SMN1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
GEMIN8 SMN2 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
ARRDC3 ZRANB1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
FLT1 PTPN11 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
HIF1A EGLN3 â—¼   HYDROXYLATION ✅ 0.88 0.88 mint 5217229 15474027
EP300 SMAD2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11371641 21988832 10199400 12237408 11264182 15623506
GATA3 KDM1A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 35140242 26028330 31409898
MCL1 USP9X â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 23171055 20023629 21907705 21566062 23097624 34079080
YAP1 LATS1 â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 25283809
YAP1 CTNNB1 â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 22234184 8383887
LATS2 YAP1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 18640976 21041410 25670202 34404733 30865227 33368671 18413746 18565851 26578655 28205554 28754671 25751139 19797269 30472188 29183995 28628118 21832154 25796446 22863277 26598551 21041411 30266805 19919647
YAP1 CTNB1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 24976009 21376238 23245941 27173435 33643786 29789528 27684187
SMAD2 SMAD1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 9111321 28628118 18729074 28205554
IGF1R IRS1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 7559507 8776723 10082579 7541045 8530377 33991522 8895367 12220227 15629149 8662806
AMOT LATS1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 30266805 32292505 24101513 24255178 34079125 24366813
SMN1 DDX20 â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 11714716 5214807
PCM1 MIB1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 31462741 26638075 21956701 24121310 25795303 33961781 34079125
EP300 SMAD4 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
AMOT YAP1 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
FBXW7 JUN â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
ARRDC3 UBE2D1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HuRI 32296183
IGF1R SHC1 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
HUWE1 UBE2D1 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
GRB10 IGF1R â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
ARRDC3 BAG3 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HuRI 32296183
DVL2 BAG3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 31340145 16189514 16713569 21516116
NFKB2 FBXW7 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 14743216 25720964 22864569 33658012 32350066 22388891
CTNNB1 YAP1 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
AMOT YAP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 30266805 23564455 24976009 24225952 25751139 31501420 32292505 29891922 30472188 24106267 24255178 24101513 32755583 24366813 19615732 22385262
SMAD1 YAP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 19914168 21685363
IGF1R SHC1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 7559507 24051437 8776723 7541045 14764897 15629149 16113100
SMAD2 JUN â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11371641 20195357 10220381 25609649
HIF1A SMAD3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12228247 28471448 11486006 14741200
KC1E AXIN1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11884395 22682247 26496610 21988832
DVL2 WWP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 34139860 26701932 31340145
MARK4 USP9X â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 14676191 18254724
USP9X AFAD â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 9722616 10620020
SAV1 LATS2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 25670202 34404733 25692647 24255178 30266805
ITCH UBC â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
HIF1A UBC â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
BIRC2 UBE2D1 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
BRCA1 UBE2D1 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
EP300 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21102443 19887647 10655477 11782371 16713569 21212407 22787115
JUN BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12080089 25609649 16713569
MYC BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12646176 11916966 16713569 20215511 9788437 30415952 14612409
BRCA1 NFE2L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15520196
HIF1A EGLN3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25416956 18402654 18063574 16511565 15474027 31239290 24015760 17069766 17353276 16155211 30067985 26972000 23345396 15721254 18264140
EP300 JUN â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 27956703 21268080 21937452 24069158 11689449 14630807 11980644 10327051 12437352 12471036 24636898
EP300 HDAC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15102857 19344692
FBXW7 MYC â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 27795300 31569395 35140242 15150404 33494392 15498494 28007894 23750012 31638140 17646408 28209614 16023596 17157259 25716680 20970423 23791182 32021252 30606768 32345600 17873522 33821962 31152129 20848231 32047362 22524983 17314511 25720964 31285543 32350066 33086033 15103331
MCL1 HUWE1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16213503 21730980 22552282 32378766 28193319 20023629 15989957 21907705 27517746 21298030 34314700 21613222 33961781 25147182 29799788 20007713 19148187 21507240
SNAI1 KDM1A â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25639869 20562920 23011797 33961781 26186194 20389281 21300290
MTOR RPTOR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16847060 26522726 12604610 19619545 26348909 33378666 20169205 24036451 18570873 24516643 19299511 34031390 22424946 22356909 25940091 12719976 22544753 23263282 12150926 12665511 18505677 17277771 17461779 22493283 19114562 18722121 21071439 18030348 19446321 12718876 12747827 24375676 22258093 16837165 21045808 16962653 18955708 17565979 12408816 15467718 23953116 27043084 23911927 17043309 31601708 21177249 21614075 21795849 16631613 20381137 21321085 23297343 23872070 16354680 19875983 25446900 29059166 24337580 16603397 16183647 34171383 15066126 24403073 25332233 17386266 19145465 25007995 16798736 26678875 15268862 20427287 30865892 16919458 25273559 15459249 18519641 18504440 12150925
SMAD2 MYC â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11804592 28628118 28205554
MYC U5S1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17353931 17314511 29467282 30415952
SMAD1 MYC â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 15576399 22290435 22761862
MYC RHOG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC SNRPB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
MYC PHB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11983916 12695333
MYC UBA52 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC SMN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
MYC EIF4B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
AXIN1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19131971 20399964
NUAK1 USP9X â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 32707033 16306228 24785407 18254724
CDH1 PTPN11 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 16424155 16461340 17617594
PTPN11 MAP3K5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19287004
RPS6KA3 RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18722121
SIRT6 UBE2D1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
YAP1 LATS1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 18640976 27325643 32292505 27684187 27886176 21383157 18413746 33141042 26933062 24366813 31619268 28754671 30461308 27847303 25751139 29891922 17889669 30472188 28416659 25283809 24107629 22641346 18158288 25796446 22863277 20841485 24255178 21041411 34079125 30266805
YAP1 LATS2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 17974916 21832154 21205866
YAP1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23607968 22234184 23245941
TSC22D1 UBE2D1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
SHC1 ERBB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9710588 9019162 16713569 9756944 22973453 24658140 10085134 28065597 30898150 16843263 16273093 16729043 8665853
PTEN SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10427092 21206972
TEK SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14665640
MAP3K7 BCL10 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 17158449 15327770 10882101
MALT1 BCL10 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21157432 31774199 23690623 25748427 17948050 20551178 17189706 21513986 22658522 22267217 14695475 22528498 27070702 31961340 11262391 24130731 27071417 33329596 19444310 27113748 25548215 11090634 30279415 19279678 25569716 18806265 33961781 29953499 19118383 27777308
SMAD2 SMAD4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9111321 25514493 11927552 28443643 21988832 20211142 15467747 12732634 25609649 15922743 12419246 9288972 21454478 19139564 24157709 18729074 22442258 17283070 16916642 15350224 17591701 11274206 15761153 31591477 26555259 9892009 9311995 10085121 9389648 10781087 12167862 10878024 18783722 27703004 18511908 28468752 19135894 10531362 12794086 15231748 21297662 12621041 19917253 11027280 24584437 16751102 31932471 10199400 21532621 12808092 33961781 11264182 11102446 11114293 12543979 23788427 15817471
SMAD1 SMAD4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9111321 17183365 16189514 32296183 31467278 12167862 14701756 12874272 28468752 15761153 24412244 10531362 15231748 11700304 11779505 26555259 9436979 21454478
SMAD3 SMAD4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9111321 16189514 25514493 11927552 28443643 21988832 20211142 15084259 12732634 19768112 15467747 20142324 25609649 15922743 12917407 12419246 20564330 24382352 19139564 32296183 24157709 18729074 22442258 10092624 17283070 15350224 17591701 15761153 31591477 10995777 26555259 9892009 9311995 15588252 12167862 10878024 25910212 27703004 33990575 28115363 18055455 22310290 19135894 10531362 12794086 15231748 21297662 22045334 19917253 24584437 27107012 29892012 29997244 21532621 27845895 21597466 25502805 11114293 12543979 23788427
SMAD4 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12374795 10022869
SMAD4 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 22775504 17452626 24625091
MAP3K7 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9380693
SMAD2 SMAD3 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
ITCH SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15350225 23331499
SMAD2 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18729074 9111321
SMAD3 JUN â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10903323 11306568 10220381 9732876 21829441
SMAD3 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 24424784 19597490 21798735
SMAD3 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12374795 10022869
AXIN1 DVL2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10829020 29659741 23892894 21245303
AXIN1 CTNB1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10228155 27902311 30181396 24976009 20128690 12421363 17318191 19166851 18632848 19131971 16890161 26496610 20531388 23892894 32533114 18593713 21242974 22682247 19223551 9734785 17510365 16199882 23959799 12805222 29045831 22509369 29789528 34079125
JUN RELB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15596805 17446175
JUN RHOB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21565167 24636898
CUL3 CAND1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21249194 16449638 22013077 12609982 21145461 22405651 26286618
RELB NFKB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 14743216 27609421 17962807 22864569 33961781 14678988 12505990 22388891
MALT1 RELB â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 17948050 18264101 21873235
PBX1 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 29437830 21746878
MINK1 PRICKLE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22037766
BCL9 CTNB1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 24360964 15294866 11955446 34079125 31073027 17052462
HIF1A KDM4C â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19828020 32938217
FLT4 RPS6KA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12601080
USP9X CTNB1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 26717875 27783990 10620020 34097426 31073027 14742711
ERBB2 CTNB1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 7702605 11245482 11950845
TTK RPS6KA1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
RPS6KA1 WWC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24269383
GATA3 TEK â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19674970
RPS6KA3 WWC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24269383
PARK2 UBA52 â—¼   PHYSICAL_INTERACTION 902.0 0.9 STRING 36370105
EPS15 UBC â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
PTPN11 IRS1 â—¼   DEPHOSPHORYLATION ✅ - 0.9 0.9 Signor 10660596
EP300 JUN â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
RPS27A UBE2D1 â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
FLT4 SHC1 â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
PARK2 RPS27A â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
CAND1 CUL3 â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
ERBB2 SHC1 â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
EGLN3 HIF1A â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
RNF115 UBE2D1 â—¼   PHYSICAL_INTERACTION 0.92 0.92 HuRI 32296183
FBXW7 MYC â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
SHC1 USP9X â—¼   PROTEIN_INTERACTION 0.93 0.93 HIPPIE 31980649 19380743
CTNNB1 EP300 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
FBXW7 JUN â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 14739463 31843895 30044990 29225075 16023596 28036276 33086033 29346117
ERBB2 PTPN11 â—¼   PHYSICAL_INTERACTION 939.0 0.94 STRING 36370105
MALT1 BCL10 â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 17948050 6177522
CTNNB1 AXIN1 â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 5219694 17318191
FBXW7 UBA52 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
JUN UBA52 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
EP300 SMAD3 â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
RPS27A USP7 â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
SMAD4 SMAD1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 17183365 5219486
KC1E DVL2 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 16189514 16713569 31340145 32707033 23455922
UBA52 UBC â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
RPS27A UBC â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
HIF1A EP300 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 17382325 5219810
SMN1 GEMIN2 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 11714716 5214807
SMAD1 SMAD4 â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
DDX20 SMN2 â—¼   PHYSICAL_INTERACTION 964.0 0.96 STRING 36370105
DDX20 GEMIN2 â—¼   PHYSICAL_INTERACTION 964.0 0.96 STRING 36370105
DDX20 SMN1 â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
BIRC2 UBC â—¼   PHYSICAL_INTERACTION 967.0 0.96 STRING 36370105
UBC UBE2D1 â—¼   PHYSICAL_INTERACTION 968.0 0.96 STRING 36370105
HIF1A EP300 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15280364 19589782 16543236 11823643 22807441 19666581 16189267 18047470 15342390 12042299 19680224 22735262 23448368 26135796 23618863 14691445 19696166 11959990 27320910 16847340 24821806 22789427 17906695 8917528 20620956 20000859 15261140 16081065 12778114 22219185 15154850 25192544 22075993 19071119 22908229 19940151 21187066 24421387 23880760 11940656 23966271 26826385 26944191 12588875 23746844 11063749 27808477 19074848 20603618 15155277 18268343 20829524 21148070 12914934 17502379 22684029 17382325 26751287
RICTOR MTOR â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 24036451
MTOR RICTOR â—¼   COLOCALIZATION ✅ 0.97 0.97 mint 21045808 8088164
HIF1A VHL â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15082527 11865071 11226425 10944113 14556007 11986208 15527772 17973296 12538644 26735336 24899725 12606543 21358672 24015760 16611863 23401859 18062927 21332579 15805242 19940151 12086861 27281823 23413029 33060856 11292862 24316222 16155211 24857547 22932900 29121446 11292861 12101228 15060148 18047470 16278378 21602890 27320910 12464182 26611735 32589900 18402654 25500545 12050673 18694926 26215701 10878807 25361009 11641274 22351759 34007068 18305400 21316481 11024059 34195792 26037477 34174286 33039559 10823831 26743088 31810986 10353251 15833858 17558023 11566883 23580587 27563096 18985005 19123984 25438054 12682018 18323857 23387829 17442832 33550096 18222538 18426857 17047048 12004076 34230460 23318261 33961781 12808024 21335603 12586829 17353276 11358837 28514442 20724477 16140212 12205091 20049704 16862177 11331613 32535973 15721254 14691445 15385570 10973499 15611064 17981124 28775317 12925778 26496610 17339318 30237125 20458141 20639890 17986458 19147576 28425505 11504942 22369643 18264140 16511565 12351678 14600153 30988076 17132228
GRB10 IGF1R â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 18286479 8764099 9369444 12697834 8621530 8776723 9506989 19165858
BCL9 CTNNB1 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
HUWE1 UBC â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
IRS1 PTPN11 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
HDAC6 UBC â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
SMAD1 YAP1 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
NFKB2 RELB â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
SMN1 SMN2 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
RPTOR MTOR â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 24036451
MTOR RPTOR â—¼   COLOCALIZATION ✅ 0.98 0.98 mint 21045808 8088164
UBC ZRANB1 â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
HUWE1 MCL1 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
UBC USP7 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
LATS1 YAP1 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
SMAD1 SMURF1 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
IGF1R IRS1 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
AXIN1 DVL2 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
MTOR RPTOR â—¼   PHOSPHORYLATION ✅ + 0.98 0.98 Signor 19346248
RPS27A UBA52 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
LATS2 YAP1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
PARK2 UBC â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GEMIN2 SMN2 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GEMIN2 SMN1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
AXIN1 CTNNB1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
EP300 HIF1A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
MYC BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12032322 19882681 20940401 10375022 21668996 11916966 12646176 11983916
DVL2 CSNK1E â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 Reactome 12556519 21285348 11818547 11425858 10535959 16965538 10517632
CSNK1E CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 46.0 1.0 Omnipath 9312064 7641885 15265686 19718039 21602792 14966280 210606194 8655584 19705439 11818547 19029934 20093472 17430994 21606194 17884187 11955436 9482734 14747478 17570479 12176352 22017973 22433869 17143292 20006983 19072724 14704854 16965538 16443747 22007144 12000790 12114015 16547521 10488109 19020754 20940130 12417018 21640127 21087212 17127310 21796133 10023673
CSNK1E AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 21988832 10535959 22682247 11884395 26496610 11487578 12000790
CSNK1E DVL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 32888647 31515488 22609948 16189514 16713569 10517632
CSNK1E YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 24715453 23431053
UBE2D1 EGLN3 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
HIF1A EGLN3 â—¼   ENZYMATIC_REACTION ✅ 66.0 1.0 ACSN 10102273 10428030 10428780 10435632 10804084 10823814 11557773 11559532 11744734 11756417 11884613 12402042 12676992 12743597 14672622 14684737 14699081 14762718 15024076 15059920 15199147 15240700 15312748 15369676 15379897 15545625 16110315 16126909 16127144 16517405 16517406 16585195 16782875 16888645 17143338 17418790 17533374 17785433 18054315 18056423 18158893 18718909 19211554 20028863 20427344 20535745 20855962 21051947 21765015 22006996 22841746 22850421 22988108 24006507 25043024 25103413 25732824 7493931 7500013 7508926 8089148 8702901 8955077 9486205 9525945 9707622
HIF1A EGLN3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19828020 15156561 20727020 15823097 22555025
HIF1A EGLN3 â—¼   OXIDOREDUCTASE_ACTIVITY_ELECTRON_TRANSFER ✅ 16.0 1.0 Reactome 11292861 15652751 17182618 12615973 12788921 11598268 11292862 21335549 17434750 15474027 15247232 12351678 12912907 15987702 22286099 18337469
EGLN3 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 17145710 15652751 26972000 15721254 16391536 16511565 24990963 12351678 31515488 24145445 17353276 15474027
EP300 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 21988832 23331499 9169454 12237408 10199400 11264182 7878020 8047140 12958365 19171760 11371641 16027720 17074756 17469772 21269274 15623506
EP300 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 9843571 19419955 22033265 9679056 21269274
EP300 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12419246 14500836 10673036 22298955
EP300 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 75.0 1.0 Omnipath 24821806 12573436 17145710 16847340 12588875 19589782 11940656 25192544 11959990 18519678 23448368 22219185 11823643 12042299 15342390 23746844 19071119 19680224 27808477 15154850 19696166 8917528 17906695 18268343 22735262 21148070 15261140 19940151 23880760 22807441 35430356 14691445 12914934 20000859 12778114 26751287 16081065 22789427 16543236 24421387 17382325 17502379 22684029 21187066 19074848 23618863 23966271 20603618
EP300 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 9843571 11134049 12743039 15133024 15824515 15623506 16876108 21567395 16109717 17074756 20564330 10497242 15588252 17469184 15345715 11058129 10575014 16862174
EP300 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 17145710 22290435 19623618 11804596 23343194 22761862 16039586 12776737 17157259 17143292 12660246 15576399 21151179 15522869 17306568 19407812 17666529 21285352 19619488
EP300 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11050151 18987336 15806138 15060161 17410209
FBXW7 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 14739463 28036276 18930588 16023596
FBXW7 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 15498494 17145710 32047362 28007894 31569395 33821962 20399964 20970423 17157259 16023596 20852628 15103331 15150404
HUWE1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 26279298 16915296 34761308 16969074
HUWE1 MCL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 32378766 15989957 21507240 20023629 28939105 16543145 16213503
MTOR RICTOR â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10722653 11274345 11756498 12408816 12906785 16469695 16556040 16678438 17461779 17680028 18000759 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19151919 19446321 19568798 19706736 19720745 20027184 20338997 21157483 21474067 21533173 21621563 21708191 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MTOR RPTOR â—¼   PHYSICAL_INTERACTION 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
MTOR EIF4B â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 12150925 12408816 12844354 12867079 12906785 15755954 15905173 16286006 16469695 16679021 17368478 17680028 18391071 18492954 19022819 19339977 19568798 19597330 19864431 20647036 21157483 21177869 21233202 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MTOR EIF4B â—¼   SHARES_COMPLEX 31.0 1.0 ACSN 12150925 12408816 12844354 12867079 12906785 15755954 15905173 16286006 16469695 16679021 17368478 17680028 18391071 18492954 19022819 19339977 19568798 19597330 19864431 20647036 21157483 21177869 21233202 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MTOR RICTOR â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10722653 11274345 11756498 12408816 12906785 16469695 16556040 16678438 17461779 17680028 18000759 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19151919 19446321 19568798 19706736 19720745 20027184 20338997 21157483 21474067 21533173 21621563 21708191 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MTOR RPTOR â—¼   SHARES_COMPLEX 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
MTOR RPTOR â—¼   ENZYMATIC_REACTION ✅ 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
MTOR MYC â—¼   ENZYMATIC_REACTION ✅ 23.0 1.0 ACSN 12150925 12408816 12906785 15755954 16469695 17604271 17680028 18372248 18492954 19022819 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MTOR RPTOR â—¼   LOCALISATION ✅ 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
RPTOR MTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 139.0 1.0 Omnipath 15268862 24403073 20427287 22258093 21321085 19446321 15467718 19875983 17461779 12665511 12719976 16631613 21045808 21177249 23911927 24337580 25446900 24516643 18614546 12718876 12747827 16603397 17043309 18519641 22544753 25007995 27043084 19145465 23953116 19619545 16919458 24375676 15459249 16837165 16847060 25332233 12150926 22424946 26348909 12150925 18955708 20381137 22356909 17386266 17565979 18030348 16354680 20169205 19114562 21071439 27329724 35561222 16798736 15809305 22493283 17277771 15661536 16962653 1683716516603397 17604271 18676370 16183647 18505677 23297343 23872070 24036451 15066126 18570873 21614075 18722121 12408816 17599906
MTOR GRB10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15952796 21659605 21659604
MTOR IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 22570710 15952059 19561084 21282364 25973388 14769130 11287630 9335553 17698034 20863384
MYC AXIN1 â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 11274345 11283614 16713974 16940750 17558397 17873522 19131971 19366350 19751508 19836308 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 22270359 23732914 25002027 26885856
MYC AXIN1 â—¼   SHARES_COMPLEX 22.0 1.0 ACSN 11274345 11283614 16713974 16940750 17558397 17873522 19131971 19366350 19751508 19836308 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 22270359 23732914 25002027 26885856
JUN MYC â—¼   ENZYMATIC_REACTION ✅ 40.0 1.0 ACSN 11274345 11929833 11955436 11967263 12051714 15001769 15576399 15768032 15806138 16007074 16039586 16169192 16510874 17050667 17143292 17291450 17439715 17936032 18347071 18627596 19619488 19623618 20006983 20122174 20530697 20705860 20920541 21285352 21767405 22290435 22705350 22761862 23306204 23343194 24023259 25730849 26587781 7542250 8545107 8666229
RPTOR MYC â—¼   ENZYMATIC_REACTION ✅ 23.0 1.0 ACSN 12150925 12408816 12906785 15755954 16469695 17604271 17680028 18372248 18492954 19022819 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
BCL9 MYC â—¼   ENZYMATIC_REACTION ✅ 23.0 1.0 ACSN 11955436 11967263 12051714 15001769 15576399 16039586 17143292 17306568 17666529 17671186 17936032 19619488 19623618 20705860 21151179 21285352 22290435 22761862 23343194 24023259 25730849 7542250 8666229
MYC HIF1A â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10432118 11274345 11283614 11875494 16327802 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21093321 21372296 21406394 21765015 2191300 22067385 22461508 23124025 23390297 25002027
JUN MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 21835891 8276360 1774959 2498162 21607323 20410304 14523011 18037408
SMAD4 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11689553 17132729
HIF1A MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 20404562 23059786 19845622 18616527 15780936 21303984
CTNNB1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 21533051 19778454 16510874 12095419 17360646 18852287 15576399 19561604 20300972 19662654 15579438 17724465 9727977 24447505 18679417 12907606
SMAD3 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 15930298 20516082 14993291 17132729 16205635 25238097 11689553 17114344
MYC CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9632747 19176757 23364919 10523846
MYC PTEN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23135913 19578399 12695333
MYC ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20920219 21627565 7906953 23421821 20716114
MYC VHL â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22286234 12695333
MYC BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17170079 19287963 20508797 19602047
JUN MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 29.0 1.0 Omnipath 15806138 16510874 22290435 18627596 19623618 11929833 23343194 15768032 22761862 17050667 16039586 20122174 17291450 20920541 17143292 20006983 17439715 15576399 21767405 23306204 8545107 22705350 18347071 16007074 16169192 21285352 20530697 19619488 11274345
CTNNB1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 19751508 7542250 11967263 22290435 19623618 16574648 23343194 11955436 22270359 22761862 16039586 15810077 17143292 12051714 8666229 22943793 15576399 21151179 16940750 17306568 17666529 21285352 19619488
MYC SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 11804592
MYC SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 11804592
NUAK1 LATS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 19369195 18691976 19927127 19690332 19413330 18669648
PTPN11 ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 9756944 16273093 16729043 32024694
PTPN11 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 26.0 1.0 Omnipath 7515062 11788580 7935386 9535915 11781100 10660596 9756938 7513703 8505282 9303488
PTPN11 IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 28065597 23331499 11779860 7642582 10082579 8895367
RPTOR EIF4B â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 12150925 12408816 12844354 12867079 12906785 15755954 15905173 16286006 16469695 16679021 17368478 17680028 18391071 18492954 19022819 19339977 19568798 19597330 19864431 20647036 21157483 21177869 21233202 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
RPTOR EIF4B â—¼   SHARES_COMPLEX 31.0 1.0 ACSN 12150925 12408816 12844354 12867079 12906785 15755954 15905173 16286006 16469695 16679021 17368478 17680028 18391071 18492954 19022819 19339977 19568798 19597330 19864431 20647036 21157483 21177869 21233202 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
RPTOR HIF1A â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 12150925 12777372 15755954 15854902 16469695 16915281 17991864 19299511 19864431 19942859 20484410 22025673 22841746 23087689 26159692
RPS6KA1 RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 18220336 19369195 21325048 18722121 18439900 19413330 18669648 25361081
PRKAA2 RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 18220336 19369195 18722121 18439900 20083114 19413330 18669648
SMAD3 SNAI1 â—¼   PHYSICAL_INTERACTION 20.0 1.0 ACSN 11074002 11279127 11792802 12702545 12809600 15265520 16179589 16713975 17018611 17563753 18768831 19597490 21041997 21042762 21577210 21614932 22331441 22514743 8515656 9389648
SMAD4 SNAI1 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16179589 16510505 16617148 16713975 16831886 17018611 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18768831 18832382 19208835 19412634 19597490 20731704 21041997 21042762 21199805 21317430 21577210 21614932 21883379 22006115 22331441 22406545 22514743 22945800 8515656 9389648
SMAD3 SNAI1 â—¼   SHARES_COMPLEX 20.0 1.0 ACSN 11074002 11279127 11792802 12702545 12809600 15265520 16179589 16713975 17018611 17563753 18768831 19597490 21041997 21042762 21577210 21614932 22331441 22514743 8515656 9389648
SMAD4 SNAI1 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16179589 16510505 16617148 16713975 16831886 17018611 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18768831 18832382 19208835 19412634 19597490 20731704 21041997 21042762 21199805 21317430 21577210 21614932 21883379 22006115 22331441 22406545 22514743 22945800 8515656 9389648
SNAI1 PTEN â—¼   DOWN_REGULATES ✅ - 66.0 1.0 ACSN 10048576 11283614 11708773 12490555 12545156 12668723 14623871 14673164 15111329 15151915 15155580 15181457 15448698 15459715 16001073 16079281 16232121 16510505 16556862 16617148 16716598 16831886 17018611 17055429 17093497 17403902 17490644 17537911 17550342 17563753 17615296 17671186 18172008 18297062 18832382 19208835 19412634 19564415 19597490 19935649 20027199 20702634 20706219 20713526 20731704 21041997 21051859 21159887 21199805 21317430 21577210 21685935 21883379 2191300 22006115 22286765 22406545 22439866 22514743 22796940 22945800 23140366 23869868 8844971 9157999 9618481
SMAD4 SNAI1 â—¼   UP_REGULATES ✅ + 41.0 1.0 ACSN 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16179589 16510505 16617148 16713975 16831886 17018611 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18768831 18832382 19208835 19412634 19597490 20731704 21041997 21042762 21199805 21317430 21577210 21614932 21883379 22006115 22331441 22406545 22514743 22945800 8515656 9389648
SNAI1 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 71.0 1.0 Omnipath 16502042 16424022 18347060 19874710 23054398 11912130 12668723 21081648 24168186 20455091 16617148 19635798 24424621 15300012 22775504 12508111 25025961 23637992 20576520 24228088 18701475 20562920 22562246 23424071 21685935 15026811 24504364 18801366 19055748 18321996 17060462 23295740 22128911 23752226 24293287 16273209 19893985 18385519 23671646 17724139 24305977 20801642 10655587 15492833 19789323 21846773 19784072 17082242 17671186 22911555 14673164 16804902 17490644 23658826 18519590 12579345 22158034 17655524 24095903 18565826 20053763 15311212 15448698 19179606 12161443 22614005 18773488 21796367 24448241 16322400
SMAD3 SNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 20731704 9389648 18832382 16831886 17563753 22406545 11074002 21317430 16617148 17671186
LATS2 SNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 34335956 27840647 26831822 21952048 24168186
PRKD1 SNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 20940406 24954011 25122124 28056869 24565133 19923321 26848698 22791710 25203322 22276203 29789636
SNAI1 CDH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 15169839 17615296 22796940 20818389 21685935 20519943 12508111 11309385 17018611 22514743 19597490 14673164
USP7 MARCHF7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 27302477 23105109 16713569 18410486
ITCH YAP1 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 10940313 11318614 16469705 16861923 18552861 18628966 21107885 21383157
LATS2 YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 36.0 1.0 Omnipath 22863277 20048001 18413746 24525530 15302935 19797269 17974916 18640976 18369314 29179447 18669648 25670202 26578655 29680477 18565851 21233212 21041410 18158288 19919647 18220336 21832154 22658639 21041411 24976283 26598551
AMOT YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 32755583 21205866 26269582 21808241
LATS1 YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 48.0 1.0 Omnipath 22863277 24366813 35044719 20048001 18413746 17889669 15302935 21383157 23752589 17974916 18640976 22641346 23027127 20841485 18369314 29179447 18669648 24255178 18565851 21909427 21170084 25283809 29487715 18158288 29496737 18220336 22658639 35210364 27325643 19141641 21041411 25180175 27322327 27847303
YAP1 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19914168 35044719 23431053 21685363
VHL UBE2D1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
PEX5 UBE2D1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 21554508 19208625 17726030 18359941 10562279
UBE2D1 HIF1A â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
MAP3K7 PRKAA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16054096 16054095 15509864 19197243 17244528 18692468 15980064
FLT1 SHC1 â—¼   PHYSICAL_INTERACTION 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
FGFR3 SHC1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9045692 9480847 18840094 7559490
SHC1 FLT4 â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
FLT1 SHC1 â—¼   SHARES_COMPLEX 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
SHC1 FLT4 â—¼   SHARES_COMPLEX 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
FLT1 SHC1 â—¼   ENZYMATIC_REACTION ✅ 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
IGF1R SHC1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 10086337 10826997 12175651 12444011 12767520 16931767 17145802 19030972 21540285 24103846 24782617
SHC1 FLT4 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
ERBB2 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 28065597 23331499 9756944 16273093 8026468 9710588 10085134 24658140 9590694 16713569 16729043 16843263
IRS1 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 9202037 10807918 7499194
FLT4 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 9388490 7675451 9096689 15592455 9121430 9446569 10891441 11687594 23331499 10921922 10482988 10764799 12522270 9685404 10896916 9927207 8662748 8702728 12237775 8610109 9741627 9710204 10816433 11075717
IGF1R SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 12767520 15629149 7541045 17145710 8776723 7559507 14764897 17570479 16113100 24051437 17673906
FLT3 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 72.0 1.0 Omnipath 19901323 9388490 20230923 15769897 9096689 16497976 9121430 15592455 9446569 10891441 17389395 11687594 18578522 10921922 10482988 10764799 18452278 20068231 18669648 12522270 9685404 10896916 9927207 12237775 8702728 8610109 19651622 9741627 9710204 19664994 17016520 10816433 11075717
BCL10 MALT1 â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 11280761 11356195 11460167 12356734 14660645 16809782 16818229 17052756 17301840 17363905 17462996 17948050 18264101 18264787 20685844 21133840 21199863 21232017 21873235 24560716 24699077 24958845
BCL10 MALT1 â—¼   SHARES_COMPLEX 22.0 1.0 ACSN 11280761 11356195 11460167 12356734 14660645 16809782 16818229 17052756 17301840 17363905 17462996 17948050 18264101 18264787 20685844 21133840 21199863 21232017 21873235 24560716 24699077 24958845
SMAD3 SMAD4 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
SMAD2 SMAD4 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
SMAD4 SMAD3 â—¼   PHYSICAL_INTERACTION 72.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013125 11013220 11074002 11114293 11224571 11279127 11283613 11283614 11376132 11399519 11792802 11875494 12193690 12545156 12702545 12809600 14976548 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 16831886 17018611 17055429 17260466 17550342 17563753 17689680 17705132 18353785 18768831 18832382 19208835 19597490 19815509 19901969 20027199 20713526 20731704 21041997 21042762 21098712 21252118 21317430 21577210 21614932 2191300 22331441 22514743 22652804 23140366 23338822 23390297 23784029 23869868 25374926 6357187 8515656 8871614 8893010 9312026 9389648 9618481 9670020
SMAD4 SMAD2 â—¼   PHYSICAL_INTERACTION 52.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11399519 11792802 11875494 12193690 12545156 12702545 12809600 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 17055429 17260466 17550342 17689680 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23390297 23784029 23869868 6357187 8515656 8871614 9312026 9389648 9618481 9670020
SMAD4 SMAD3 â—¼   PROTEIN_INTERACTION 72.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013125 11013220 11074002 11114293 11224571 11279127 11283613 11283614 11376132 11399519 11792802 11875494 12193690 12545156 12702545 12809600 14976548 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 16831886 17018611 17055429 17260466 17550342 17563753 17689680 17705132 18353785 18768831 18832382 19208835 19597490 19815509 19901969 20027199 20713526 20731704 21041997 21042762 21098712 21252118 21317430 21577210 21614932 2191300 22331441 22514743 22652804 23140366 23338822 23390297 23784029 23869868 25374926 6357187 8515656 8871614 8893010 9312026 9389648 9618481 9670020
SMAD4 SMAD2 â—¼   PROTEIN_INTERACTION 52.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11399519 11792802 11875494 12193690 12545156 12702545 12809600 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 17055429 17260466 17550342 17689680 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23390297 23784029 23869868 6357187 8515656 8871614 9312026 9389648 9618481 9670020
SMAD4 SMAD3 â—¼   LOCALISATION ✅ 72.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013125 11013220 11074002 11114293 11224571 11279127 11283613 11283614 11376132 11399519 11792802 11875494 12193690 12545156 12702545 12809600 14976548 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 16831886 17018611 17055429 17260466 17550342 17563753 17689680 17705132 18353785 18768831 18832382 19208835 19597490 19815509 19901969 20027199 20713526 20731704 21041997 21042762 21098712 21252118 21317430 21577210 21614932 2191300 22331441 22514743 22652804 23140366 23338822 23390297 23784029 23869868 25374926 6357187 8515656 8871614 8893010 9312026 9389648 9618481 9670020
SMAD2 SMAD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16052471 11376804 11456453 9812998
SMAD3 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 104.0 1.0 Omnipath 25609649 9843571 15084259 20211142 21532621 24584437 18729074 23788427 12419246 18923419 9892009 19768112 10531362 15231748 9679060 12167862 21988832 12150994 23331499 12543979 18568018 21071413 19135894 15467747 25502805 9732876 11927552 16189514 12917407 25514493 15350224 10995777 18988627 10092624 12732634 25910212 10878024 9111321 20564330 27107012 9311995 12957874 20142324 11114293 32296183 15588252 15761153 24157709 26555259 29892012 17469184 22442258 16714330 21597466 15922743 22045334 17591701 24382352 22310290 19139564 19917253 29997244 31515488 28115363 10942775 21297662 17283070 12794086
USP9X SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22298955 19135894 20016939
JUN SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10220381 9312063 9732876
SMAD2 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 110.0 1.0 Omnipath 15613484 17145710 25609649 15817471 20211142 21532621 24584437 18729074 23788427 12419246 16916642 9288972 9892009 21454478 17510063 10531362 15231748 11027280 12167862 21988832 9389648 23331499 12543979 18568018 21071413 19135894 18511908 15467747 12808092 11927552 25514493 15350224 18988627 12732634 10878024 9111321 9311995 9346908 10199400 11264182 12957874 11114293 15761153 11274206 12621041 17272273 24157709 26555259 12374795 22442258 10781087 15922743 11102446 17591701 18783722 16751102 19139564 19917253 9346966 21297662 17283070 12794086
SMAD1 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 34.0 1.0 Omnipath 17183365 9436979 24412244 11779505 31467278 21454478 10531362 15231748 12167862 23331499 21071413 11700304 12874272 16189514 18988627 20957627 9111321 15761153 32296183 26555259 14701756 14534577
MAP3K7 MAP2K3 â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 10391247 11280761 11460167 11477091 12620219 14633987 14660645 15082531 15125833 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20164171 21041997 21133840 21232017 22941947 23681101 24403530 24699077 24958845
IRAK1 MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12242293 17197697
MAP3K7 MAP2K3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17299140 21902831 23331499 8663074 12791976
SMAD3 SMAD2 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10454538 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23869868 8515656 9312026 9389648 9618481 9670020 9865696
SMAD3 SMAD2 â—¼   PROTEIN_INTERACTION 41.0 1.0 ACSN 10454538 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23869868 8515656 9312026 9389648 9618481 9670020 9865696
SMURF1 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10458166 23331499 15221015 20207742 15231748
WWP1 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 15221015 15946939 15359284
SMAD2 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 21988832 26186194 12543979 9111321 15084259 9311995 25878769 18729074 12700238
AXIN1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11438668 23331499 18988627
SMURF1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10458166 23331499 15221015 15761153 15231748
SMAD3 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23331499 9732876 10220381 11306568 21829441 10903323
PTEN IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16288286 10648629 17218262 12040186 15584861
BCL9 AXIN1 â—¼   PHYSICAL_INTERACTION 28.0 1.0 ACSN 11955436 11967263 12051714 15001769 15576399 16039586 16288291 16940750 17143292 17306568 17666529 17671186 17936032 19619488 19623618 19751508 20006983 20705860 21151179 21285352 22270359 22290435 22761862 23343194 24023259 25730849 7542250 8666229
BCL9 AXIN1 â—¼   SHARES_COMPLEX 28.0 1.0 ACSN 11955436 11967263 12051714 15001769 15576399 16039586 16288291 16940750 17143292 17306568 17666529 17671186 17936032 19619488 19623618 19751508 20006983 20705860 21151179 21285352 22270359 22290435 22761862 23343194 24023259 25730849 7542250 8666229
BCL9 AXIN1 â—¼   ENZYMATIC_REACTION ✅ 28.0 1.0 ACSN 11955436 11967263 12051714 15001769 15576399 16039586 16288291 16940750 17143292 17306568 17666529 17671186 17936032 19619488 19623618 19751508 20006983 20705860 21151179 21285352 22270359 22290435 22761862 23343194 24023259 25730849 7542250 8666229
DVL2 AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10329628 10829020 21245303 23892894 16713569 17529994
AXIN1 MAP3K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 20128690 23331499 11408485 10829020 21071413 15262978 11884395 10575011 12878610
AXIN1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 52.0 1.0 Omnipath 20128690 20531388 16890161 27902311 22509369 18593713 16199882 23331499 9482734 21071413 26496610 19244247 22773187 17318191 10196136 18988627 17208333 19131971 24976009 22682247 10228155 12805222 12000790 10488109 9501208 9601641 18632848 9554852 19166851 23959799 12421363 9734785 11940574
PRICKLE1 SMURF1 â—¼   PHYSICAL_INTERACTION 28.0 1.0 ACSN 11226259 14657501 14704854 14722617 14744429 14747478 15265520 15265686 15618519 15761148 16263762 17127310 17884187 18497258 18851840 19020754 19379695 19565474 19853559 20006983 20930545 21087212 21397842 21572392 22017973 22949611 7641885 8655584
PRICKLE1 SMURF1 â—¼   SHARES_COMPLEX 28.0 1.0 ACSN 11226259 14657501 14704854 14722617 14744429 14747478 15265520 15265686 15618519 15761148 16263762 17127310 17884187 18497258 18851840 19020754 19379695 19565474 19853559 20006983 20930545 21087212 21397842 21572392 22017973 22949611 7641885 8655584
SMURF1 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 14701756 17676934 15221015 19914168 21708152 22298955 24828823 19917253 16611643 17510966 15761153 22670624 22152476 17289590 15231748 21685363 27447855
JUN BCL9 â—¼   PHYSICAL_INTERACTION 78.0 1.0 ACSN 10391247 11274345 11929833 11955436 11967263 11973335 12051714 12417340 12711682 15001769 15060161 15082531 15208637 15279786 15327769 15337521 15576399 15768032 15806138 15834423 16007074 16007092 16039586 16169192 16510874 16547505 16554443 16940750 17050667 17143292 17291450 17303408 17306568 17439715 17565603 17660363 17666529 17671186 17936032 18347071 18590585 18627596 19216735 19506021 19619488 19623618 19751508 19751731 19879327 19901072 20006983 20107328 20122174 20144767 20530697 20705860 20920541 20964627 21151179 21285352 21416054 21681822 21767405 22020335 22270359 22290435 22705350 22761862 23296977 23306204 23343194 24023259 25730849 26587781 7542250 7575488 8545107 8666229
JUN BCL9 â—¼   SHARES_COMPLEX 78.0 1.0 ACSN 10391247 11274345 11929833 11955436 11967263 11973335 12051714 12417340 12711682 15001769 15060161 15082531 15208637 15279786 15327769 15337521 15576399 15768032 15806138 15834423 16007074 16007092 16039586 16169192 16510874 16547505 16554443 16940750 17050667 17143292 17291450 17303408 17306568 17439715 17565603 17660363 17666529 17671186 17936032 18347071 18590585 18627596 19216735 19506021 19619488 19623618 19751508 19751731 19879327 19901072 20006983 20107328 20122174 20144767 20530697 20705860 20920541 20964627 21151179 21285352 21416054 21681822 21767405 22020335 22270359 22290435 22705350 22761862 23296977 23306204 23343194 24023259 25730849 26587781 7542250 7575488 8545107 8666229
JUN BCL9 â—¼   ENZYMATIC_REACTION ✅ 78.0 1.0 ACSN 10391247 11274345 11929833 11955436 11967263 11973335 12051714 12417340 12711682 15001769 15060161 15082531 15208637 15279786 15327769 15337521 15576399 15768032 15806138 15834423 16007074 16007092 16039586 16169192 16510874 16547505 16554443 16940750 17050667 17143292 17291450 17303408 17306568 17439715 17565603 17660363 17666529 17671186 17936032 18347071 18590585 18627596 19216735 19506021 19619488 19623618 19751508 19751731 19879327 19901072 20006983 20107328 20122174 20144767 20530697 20705860 20920541 20964627 21151179 21285352 21416054 21681822 21767405 22020335 22270359 22290435 22705350 22761862 23296977 23306204 23343194 24023259 25730849 26587781 7542250 7575488 8545107 8666229
JUN IRS2 â—¼   ENZYMATIC_REACTION ✅ 37.0 1.0 ACSN 11274345 11955436 11967263 12051714 12417340 15001769 15279786 15337521 16007092 16039586 16510874 17143292 17303408 17439715 17565603 17660363 17936032 18590585 19619488 19623618 19879327 20006983 20144767 20530697 20705860 20920541 21285352 22020335 23296977 23343194 24023259 25730849 26587781 7542250 7575488 8545107 8666229
CTNNB1 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20300972 19671687 16007074 9990071
JUN GJA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8606973 16978907 12064606 15618352 10421804
JUN CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17146436 18347071 16007074
HIF1A BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22925504 16847054 19245702 23732337
CTNNB1 BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19778454 17005722 19662654 11517919 16288908
CUL3 NFE2L2 â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 15703371 16697054 17312394 17884153 18931676 19560419 19622404 19686080 19809470 19818716 19847258 23030059 23850759
NFKB2 RELB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 17145710 20126461 16551621 17072323 16970925 16793322 12709443 11687592 9681829 17962807 14743216 17254973 15218526 7925301 16108830 12927781 17561400 15371334 16285893 15145317 19098713 12505990 17548614 17072322
CDH1 CTNNB1 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
CDH1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 91.0 1.0 Omnipath 17145710 7542250 11348595 9512503 10652321 19016843 16909210 9233779 17220478 16219695 27177845 25344754 11245482 22752307 16983094 16212417 16574648 18593713 9535896 9819408 12830000 10772923 11801604 23180380 8227214 16546130 10085258 22056988 9700170 12640114 24424122 10381631 17087658 24798214 11226248 12875984 9405455 11712088 12061792 17909039 22158051 11960376 14706341 11254878 15023525 12169098 21255999 16125672 22850631 16126725 11113628 25468996 9326449 17524503 17057644 7876318 11401320 22715382 7954478 18593907 21152425 22375065
IGF1R MAP3K5 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10086337 10826997 11274345 12175651 12444011 12556535 12655147 12767520 16931767 17145802 17673906 19030972 21540285 24103846 24782617
MAP3K5 MAP2K3 â—¼   ENZYMATIC_REACTION ✅ 14.0 1.0 ACSN 11274345 12556535 12655147 12738796 15592525 17462996 18641653 18855897 19392652 21133840 21232017 21614932 23850759 24378531
MAP3K5 MAP2K3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 23331499 11029458 16709866 12655147 21614932 12738796 11274345 19880523 21771788 19805025 8974401 19920149 18855897
MAP3K1 MAP2K3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 7839144 17143273 11971971 9639556
RPS6KA1 EIF4B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 15187187 21233202 17924679 16286006 16083285 15071500 17664694 16763566 19114553 19413330 15239952
DVL2 LRRK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 20006983 19625296
LRRK2 SNCA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 20127702 22924508 22658533 24907399 19576176
BCL9 SMAD1 â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 10391247 11955436 11967263 12051714 15001769 15082531 15576399 16039586 17143292 17936032 19619488 20705860 22290435 22761862 23343194 24023259 25730849 7542250 8666229
BCL9 SMAD1 â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 10391247 11955436 11967263 12051714 15001769 15082531 15576399 16039586 17143292 17936032 19619488 20705860 22290435 22761862 23343194 24023259 25730849 7542250 8666229
BCL9 IRS2 â—¼   ENZYMATIC_REACTION ✅ 37.0 1.0 ACSN 11274345 11955436 11967263 12051714 12417340 15001769 15279786 15337521 16007092 16039586 16510874 17143292 17303408 17439715 17565603 17660363 17936032 18590585 19619488 19623618 19879327 20006983 20144767 20530697 20705860 20920541 21285352 22020335 23296977 23343194 24023259 25730849 26587781 7542250 7575488 8545107 8666229
BCL9 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 17145710 15294866 23331499 11955446 17052462 15371335 24360964 15208637
HIF1A VHL â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
VHL HIF1A â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
HIF1A VHL â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 12205091 15930297 21887475 22150821 22396654 15962286 23159849 17482131 17140440 16883594
VHL HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 123.0 1.0 Omnipath 17145710 21332579 24857547 12682018 26496610 11292861 11024059 15060148 16278378 12586829 17353276 12004076 12205091 17339318 10823831 11226425 21602890 16862177 15611064 12351678 16140212 11865071 26037477 16611863 10973499 23401859 25361009 11331613 18305400 25438054 14691445 17047048 12538644 22932900 18985005 26735336 21358672 18323857 10878807 19147576 16511565 17973296 23413029 24316222 11986208 12808024 12464182 23318261 22369643 19940151 15721254 20724477 21335603 16391536 23387829 18694926 26743088 14556007 18264140 10353251 15082527 11358837 11292862 11566883 12050673 19123984 17558023 27281823 15805242 11641274 25500545 34174286 24899725 12606543 32535973 17132228 24015760 12086861 11504942 35589690 26215701 22351759 12925778 18222538 17986458 14600153 10944113 23580587 26611735 18426857 20049704
HIF1A FLT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 7539918 1823643 12829734 9159130 13130303 9746763 12080085 11566883 10403805 8943284 15451019 11528470 9278421 16887934 9295307
IGF1R IRS1 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10086337 10826997 11274345 12175651 12444011 12556535 12655147 12767520 16931767 17145802 17673906 19030972 21540285 24103846 24782617
JAK3 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 7544789 9233603 7499365
IGF1R IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 44.0 1.0 Omnipath 7541045 12444011 19030972 10082579 16931767 21798082 12220227 11259577 12767520 10826997 23331499 17827393 7504175 21071413 7559507 11572799 27856640 12175651 17570479 15829723 18988627 15629149 11557037 20670944 8530377 21540285 8776723 25886138 8662806
RPS6KA1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17709744 15364919 17081983 21798082
IGF1R CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17496910 22558232 12040186 19568798 14585353
IGF1R IRS4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 9553137 18988627 11316748
IGF1R GRB10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 19165858 8776723 8764099 8621530 12697834 9506989
IGF1R IRS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 8662806 9852124 10471495
PAK4 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 28007610 22173096 26068882 25560280 23543898 30755582 29330094 29399291 25335797
PRKD1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 26895471 19141652 29108267
PRKD1 HDAC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 21357900 22865920 28681592 16584705 11114197 25514029 26137861 20621068 19655095 25362149 15367659 11081517
FLT3 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17496910 22558232 17851558 12040186 19568798 22126602 14585353
JAK3 IRS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 7499365
NUAK2 LATS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 19369195 18691976 19927127 19690332 19413330 18669648
ERBB2 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 17496910 7702605 7999105 22558232 14517306 11245482 11950845 12040186 19568798 23576562 14585353 23640056
SOX2 NANOG â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17068183 16153702 21816365 19829295
SOX2 NANOG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22745796 23939864 15860457 18537119 17324942 19522013
RHOD PAK6 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11784792 28486133 22665057 31871319 17916560