Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
EGFR RAB7A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18776048 0806158105
EGFR HRAS â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
EGFR HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 17673906
EGFR ARF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24797263 20029029
EIF2AK3 SLC7A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19029953
CANX CISD2 â—¼   COLOCALIZATION 2.0 0.8 intact 20010695 7712851
RASA1 HRAS â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5221569 9219684
HRAS BLZF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TRIO RAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18212043 18066058
RAC1 KTN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 31871319 8769096
RAC1 KTN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8769096
PTPN2 ITGA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15592458 8284715
PTPN2 ITGA1 â—¼   COLOCALIZATION 2.0 0.8 intact 15592458 8284715
ITGA1 PTPN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15592458
PTPN2 GJA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24849651
FSCN1 RAB1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
RHOG DOCK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216557 12879077
RHOG ELMO1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216557 12879077
SLC16A7 KTN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
SYNE2 STXBP3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
CAV2 EGFR â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
RAB11B RAB7A â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
ATP6AP2 VMA21 â—¼   PHYSICAL_INTERACTION 806.0 0.8 STRING 36370105
ARHGDIA RAC1 â—¼   GTPASE_REACTION ✅ - 0.81 0.81 Signor 20696765
EGFR SPCS2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 20029029 31980649
ICAM1 GIT2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
ARF6 NCLN â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 17353931
RAB2A RAC1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31871319 26344197
RAC1 FAT1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31871319 31980649
PTPRF RHOA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31871319 25458010
RHOA FAT1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31871319 31980649
RAB1A RAB2A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 26344197
ELMO3 DOCK1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
DOCK5 DOCK1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 32203420 33961781
CD97 BET1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
BET1 STX6 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33961781 29568061
MMGT1 GOSR2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 32296183 27342126
TMEM9 STX6 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 32296183 33961781
RAB7A RHOG â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31871319 26496610
ELMO3 DOCK5 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
ELMO3 ELMO1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
TMX1 EPHA7 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
CXCR4 ITCH â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
HMOX2 CISD2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
STX6 STX10 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 34079125 33961781 26186194
VTI1B STX10 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
VTI1B VPS45 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
RAB7A ARL8B â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28325809 29360040 26344197
TRIO RHOG â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 25065758 32203420 31871319
DAAM1 RHOA â—¼   PHYSICAL_INTERACTION 833.0 0.83 STRING 36370105
BET1 GOSR2 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
SNX2 EGFR â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 24797263 9819414
RAC1 TRIO â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
DLG1 KCNJ12 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
STX10 VTI1B â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
DOCK5 ELMO1 â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
RAB11B RAB8A â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
GOSR2 SEC22B â—¼   PHYSICAL_INTERACTION 844.0 0.84 STRING 36370105
KTN1 RHOA â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 8769096 12773565 31871319 11162552 11689693
ELMO1 RHOG â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 21930703 12879077
ARF6 RAB1A â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 34079125 22939626
EGFR PTPRF â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24797263 31980649 24189400
DOCK1 RHOG â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 31871319 12879077
GOSR2 STX6 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 25416956 33961781 26186194
ELMO1 DOCK5 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 21930703 28514442 33961781 26186194 32203420
TRIO PTPRF â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 8643598 27880917
IL6ST JAK1 â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
RASA1 CAV2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15504032 12091389
BET1 GOSR2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 32296183 33961781 29568061
ATP6AP2 TMEM199 â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
VTI1B STX6 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 27791468 33961781 26186194 34079125
MMGT1 EMC10 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 32439656 22119785 26496610 27342126 33961781
RAB11B RAB1A â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
PTPRJ EGFR â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 19836242 9115287 19167335
EGFR RASA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 1633149 22973453 1385407 8647858 16273093 1850098
EGFR ARF6 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 34079125 24797263 20029029 31980649
RAB1A RAB8A â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 33961781 26824392
GOSR2 STX6 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
STX6 VPS45 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 34079125 33961781 26186194
RAB7A RAB2A â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 34079125 26344197 26496610
MAGT1 STT3B â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22939629 28720733 26344197
DOCK1 RAC1 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
EGFR RASA1 â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
RAB1A RAB8A â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
EGFR RHOA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
EGFR CAV2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31980649 24658140 15273741 25402006 16799092
EGFR JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8524316 15284024
NGF NTRK1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10713102 10490030 9857023 1849459 9083066 14985763 11738045 11729324
DOCK1 RAC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15723800 15247908 12134158 9808620 31871319 25468898 26344197
RAC1 TRIO â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21422296 25065758 31871319 32203420 11595749
DVL3 RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 12533515
RAC1 IQGAP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8702968 8756646
DAAM1 RHOA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 25241761 31871319 11779461 33961781 16630611 18218625 18162551
TRIO RHOA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31871319 26344197 10948190
TRIO RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9464532 10948190
CANX B2M â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 14681859 2450918 10064069
CXCR4 ITCH â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19116316 34927784 24489825 28264927 22275353
PLXNB2 HMOX2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
KTN1 RHOG â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31871319 11162552 11689693
BMPR2 ZFYVE16 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 17356069 8893010 9136927
ELMO1 DOCK1 â—¼   PHYSICAL_INTERACTION ✅ 0.91 0.91 mint 12134158 5215575
HLA-B B2M â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 8624811 5220994
STX6 VTI1B â—¼   PHYSICAL_INTERACTION 925.0 0.92 STRING 36370105
RAC1 ARHGDIA â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 8376617 22157745
RAB1A RAB7A â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
ARHGDIA RAC1 â—¼   PHYSICAL_INTERACTION 949.0 0.95 STRING 36370105
DOCK1 ELMO1 â—¼   PHYSICAL_INTERACTION 949.0 0.95 STRING 36370105
LAMTOR3 LAMTOR2 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 8153045 21516116
DOCK1 ELMO1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 21930703 16495483 15723800 28514442 18768751 15247908 12134158 11595183 20732417 33961781 26186194 26882976 20016009
NGF NTRK1 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
EMC10 MMGT1 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
HRAS RASA1 â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
VPS45 STX16 â—¼   PROTEIN_INTERACTION 0.98 0.98 HIPPIE 12110575 32296183 33961781 28514442
STX16 VPS45 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
B2M HLA-B â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
ARHGDIA RHOA â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
MAGT1 STT3B â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
LAMTOR2 LAMTOR3 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
HRAS CDKN2A â—¼   UP_REGULATES ✅ + 15.0 1.0 ACSN 10358164 12134164 12447393 14764585 16102570 17673906 20841469 24027568 24954210 7510700 7673236 8551221 9069260 9763606 9846483
PTPN2 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 15592458 15588985 9488479 10488121 11514572 11479308
ICAM1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16799092 17145710
PTPRJ EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19836242 9115287 19167335
EGFR SCAMP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9658162
EGFR RASA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 8647858 16273093 7991458 1850098 17570479 1633149 1385407
RHOG ARHGDIG â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 19581409 8939998 11967128 11689693
JAK1 IL6ST â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 8390097 9238703 16051226 11943154
JAK1 IFNGR1 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
JAK1 IFNGR1 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
IL6ST JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 7896787 23331499 11468294 9388212 21220115 24710148 11742534 23663276 12487370
PTPN2 JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 23331499 15588985 15780598 11909529
JAK1 IFNGR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 12133952 8232552 8550631 8156998 7796299 7615558 8649432 19041276
HRAS FRS2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
RASA1 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 10769036 11389730 23331499 18829532 7628625 9219684 10592173 8663024 16713569 26721396 8360177 8537347 1904555 10394594 2833817
RASA1 CAV2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12091389 23331499 15504032
NGF NTRK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 50.0 1.0 Omnipath 17145710 8155326 9083066 11729324 27908981 22666365 17404842 24224055 25611061 14985763 9290260 9857023 28090201 12067229 23772401 10490030 11114882 27229480 1706478 11738045 10713102 9547236 1849459 9775403 17409494
ARHGDIA RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 27.0 1.0 Omnipath 17245428 22157745 11368848 17353931 11513579 10346909 9490022 20696765 22393046 27173435 19961560 16189514 11513578 10673424 21900206
ELMO1 RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15247908 17145710 15723800 14638695
TRIO RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9464532 8643598 10798395 32203420 10847683 11595749 21422296
DOCK1 RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 17145710 15723800 15247908 9808620 25533347 10592173 12134158
RAC1 MAP3K11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 11713255 16212495 8910292 12480336 11152757 9427749
RHOA KTN1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 7787244 11933159 8769096 9822636 8912005 11689693
RHOA DAAM1 â—¼   PHYSICAL_INTERACTION 53.0 1.0 ACSN 11226259 11698448 11729192 11739775 11779461 11992112 12194823 12361600 12740575 14657501 14704854 14744429 14747478 15265686 15279786 15618519 15761148 16713974 17127310 17303408 17517963 17660363 17884187 18037882 18256687 18423981 18497258 18590585 18851840 19020754 19366350 19565474 19836308 19853559 20006983 20535745 21178402 22017973 22949611 23732914 24857661 24919149 26885855 26885856 27048821 27066895 7479854 7575488 7641885 8655584 9362522 9660866 9822605
RHOA DAAM1 â—¼   SHARES_COMPLEX 53.0 1.0 ACSN 11226259 11698448 11729192 11739775 11779461 11992112 12194823 12361600 12740575 14657501 14704854 14744429 14747478 15265686 15279786 15618519 15761148 16713974 17127310 17303408 17517963 17660363 17884187 18037882 18256687 18423981 18497258 18590585 18851840 19020754 19366350 19565474 19836308 19853559 20006983 20535745 21178402 22017973 22949611 23732914 24857661 24919149 26885855 26885856 27048821 27066895 7479854 7575488 7641885 8655584 9362522 9660866 9822605
CXCR4 RHOA â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 15261139 15882617 17035340 20535745 20644254 21521526 22025564 23034983 23402812 23567181 24277834
ARHGDIA RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 10489445 20628200 11368848 17353931 9490022 9113980 25416956 20711218 16189514 15659383 14749388 11149925
DAAM1 RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11779461 25241761 18218625 20810787 19365405
RHOA KTN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 12773565 11689693 8769096 11162552
ITCH CXCR4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 28264927 19116316 24489825
NTRK1 FRS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 21071413 10092678
SEC22B RAB1A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 21532587 24917561 20966969 17287728
SEC22B SEC23IP â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 22013193 10982397 23378591 20545907 18843296 10825291 20679433 11035026
RAB1A SEC23IP â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 21532587 24917561 20966969 17287728
STX10 RAB9A â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 18195106 25343031 16885419 19620288 18946081 17488291 8440258
STX16 RAB9A â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 18195106 25343031 16885419 19620288 18946081 17488291 8440258
RHOG ELMO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12879077 17145710 21930703
RHOG KTN1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 7787244 11933159 8769096 9822636 8912005 11689693
MAP4K4 SLC9A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22216214 11369779 20936779
PTDSS1 SCARB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12016218 8999945