Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
ABL1 DNM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ABL1 EFNA5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ABL1 SP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ABL1 FLNA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ABL1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11753601 9916993
PRKCA ABL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10713049
ATF2 PABPC4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18083832 16129666
UBE2I ATM â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
MDM2 ATM â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 19816404 21986495
SP1 ATM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15837784 11466608
E2F3 ATM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18469863 12527885
E2F3 ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12527885 18319725
VDAC1 BCL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0907555106 19706527
FKBP8 BCL2 â—¼   DOWN_REGULATES ✅ - 2.0 0.8 ACSN 10409669 20139069
HIF1A BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12205045 20668552
E2F2 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11559537 18319725
DNMT1 BCL2L11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17626006 23394612
CREB1 BRCA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 9926942 6548521
EZH2 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 23624935 21406404
EP300 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23353771 23285190
BRCA1 CYP1B1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16567799
BRCA1 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18025037 16331276
FANCD2 BRCA1 â—¼   COLOCALIZATION 2.0 0.8 intact 11239454 5213674
CASP3 YWHAE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216271 12657644
HDAC1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20049841 20821348
EZH2 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20132185 21697275
RASSF1 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12024041
EGFR CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7945309
E2F3 CDC25A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15210709 18319725
E2F1 CDC25A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15210709 18319725
SLC25A11 CDKN1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
PCNA CDKN1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
FGFR3 CDKN1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RB1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9671466 14527674
AHR CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12203118 24431146
E2F3 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10030670 18319725
RPL27A CDKN1B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
CDKN1B CCND2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
AHR CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15077192 10398686
EZH2 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18980972 21765901
CDKN2A CDK6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15232106 5217098
AHR CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17070097 15111621
EZH2 CDKN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20574448
LRRK2 DDIT4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
SP1 DDIT4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15180327 17307335
E2F2 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7958836
E2F1 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14706452 18794899
E2F1 RASSF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23251702 20877461
E2F1 FANCD2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18438432
EGFR E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16299810
HDAC1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17980157 18319725
PTEN E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17218262
E2F1 E2F2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15014447 18319725
E2F1 DNMT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 15867357
E2F1 HSPA5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18840615
EGFR CRKL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16729043 5218694
SH3GL3 EMD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
EP300 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23403292 24998469
EP300 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16374512 11433299
IPO4 FANCD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1002603107 20805509
FANCD2 TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
FANCG RAB5A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RB1 MDM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218170 16374512
UBE2I MDM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12393906 20972456
SGK1 MDM2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 19756449 20438709
HIF1A MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12606552 15385570
RASSF1 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18566590
PRKCD MARCKS â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 8422248
PSMB5 TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
PSMB5 PSMB4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6175987 17948026
UBE2I SAFB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 21527249 25800734
SGK1 CREB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15733869 5217559
SP1 SGK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9415398 10614661
CREB1 SGK1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 15733869 5217559
DLST SLC25A11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
UBB TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
KPNB1 TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSPA5 TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TRAF6 TNIK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1001376 22904686
NGFR TRAF6 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 16252010 16630834
UBE2N UBE2I â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22661230 22635276
HDAC1 PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18691180 9650586
CREB1 PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7721872 12658356
PCNA CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16713569 9667749
NFKB2 CDK6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18504428
CREB1 CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20864035
CRKL ERBB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
CRKL ERBB3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
LTA4H ARPC3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
UBB NFKB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
SP1 EZR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19164283
ERBB2 CRK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
FLNA CRK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ERBB3 CRK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
CRK SP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
CRK DNM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PTEN FLNA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
SMAD4 HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10199400 11427533
SMAD4 AHR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11259615
CREBBP SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9679056 9679060
SMAD4 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9679056 9679060
SMAD4 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 9689110
HIF1A PTEN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18340011 19648120
DNMT1 PTEN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19339266 21229291
EZH2 PTEN â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 24719098 22956625
BMI1 PTEN â—¼   COLOCALIZATION 2.0 0.8 intact 19903340 8291464
PTEN BMI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19903340
PTEN SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12804776
HSPA5 BCAR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
E2F2 BCAR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
FN1 BCAR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16581250 8649368
SMURF1 BMPR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22298955 17317136
SP1 HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12847090 5216518
HDAC1 CTNNB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19166851 6823802
HDAC1 ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20037778 19435809
RB1 HDAC1 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
FGFR3 RHEB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HIF1A CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17382325 5219810
VHL HIF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218395 16511565
HIF1A ENO2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19828020
HIF1A BSG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19828020 22678117
HIF1A E2F3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20308562
HIF1A SP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19934262 15780936
SF3A1 SP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5212972 10976766
SP1 SF3A1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5212972 10976766
SP1 VCAM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11133225 7499419
SP1 CCNE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16516150 15818598
SP1 PRKCE â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 24825907 18249093
SP1 NFKB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7541912
SP1 GATA3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15486968
SP1 CDC25B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23160377 21242964
SP1 APRT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11870072 10976926
RB1 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10850422 7732011
EZH2 BMI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21465172 19351856
SLC25A6 FGFR3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
FGFR3 GATA3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CTNNB1 VHL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16983094 0606850103
PRKCA HDAC6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8307255 21952047
PRKCA PRKCE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16810323 5218785
CREB1 ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23466342 21054339
CREB1 CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17043650 16301994
CREB1 GH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16293792 22890843
CREB1 ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10698518
CREB1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 10775268
UBE2I DNMT3B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18762900 11735126
DNMT1 CFTR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1375221 10417323
YWHAE CDC25B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12871587 5216545
NFKB2 CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18504428
DLST SCFD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
CTNNB1 AHR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19651607 0902132106
RAB14 AP1G1 â—¼   COLOCALIZATION 2.0 0.8 intact 5219066 16962593
HSPA5 NFKB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
DNMT3B DNMT3A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20426865 15362956
RAB14 AHR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
E2F3 CCNE2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8618861 10733529
VDAC3 VDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
GATA3 VCAM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19674970 11397697
APC2 CTNNB1 â—¼   RELOCALIZATION ✅ - 0.8 0.8 Signor 10980707
CDKN1A CCNE1 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 16765349 5218735
MDM2 CDKN2A â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 7989562 20713054
EP300 HDAC1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 14968110 30110629 22778253 16787918 33742100 18722353 22731250
CCNE1 PCNA â—¼   PHYSICAL_INTERACTION 814.0 0.81 STRING 36370105
ARAF EMD â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 29777862 25852190
EP300 ATF2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 10327051 24069158
VHL ATM â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17353931 16678111
BRCA1 PMS2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 25184681 29656893
CD44 MTCH2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
FAF2 EMD â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22119785 34079125
VCAM1 EMD â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
EMD VAPB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 25910212
HDAC6 EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19344692 15102857 12718889 22778253 23133622
FANCG UBB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
LRRK2 MMS19 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31046837 24725412
LRRK2 PCNA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31046837 24725412
VCAM1 ARPC3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
ANLN ARPC3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31586073 26496610
RHEB UBB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
VCAM1 FLNA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
ANLN FLNA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31586073 26496610
LRRK2 VDAC1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31046837 21370995
HIF1A SP1 â—¼   PHYSICAL_INTERACTION 819.0 0.82 STRING 36370105
CFTR FKBP8 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 26618866 31324722
CFTR ARF4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 26618866 31324722
DNMT3A DNMT3B â—¼   PHYSICAL_INTERACTION 819.0 0.82 STRING 36370105
RB1 E2F3 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 5219804 17380128
VCAM1 VDAC1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
IMPA2 FSCN1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31298480 26344197
VCAM1 FSCN1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
CCND2 RB1 â—¼   PHYSICAL_INTERACTION 820.0 0.82 STRING 36370105
UBB ZRANB1 â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
LRRK2 YWHAE â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
ACTA1 FLNA â—¼   PHYSICAL_INTERACTION 825.0 0.82 STRING 36370105
CASP3 MDM2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 25241761 9278461 24842904 9840926 21726810
CCND1 RFC1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 10353443 21654808
PELP1 EP300 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 33742100 11481323
PMS2 FAN1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 25659891 27880917 26496610 20603073 20603015 17148452
FAN1 PMS1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 25659891 27880917 26496610 20603073 20603015
PCNA CCNE2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
PCNA CCNE1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
FAF2 UBB â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194 18775313
UBE2I SMAD4 â—¼   PHYSICAL_INTERACTION ✅ 0.83 0.83 mint 5217094 15231748
HDAC6 CFTR â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 31501480 22069321 14675537
CFTR RAB5A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 26618866 21455491 19398555
ANLN LMO7 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 33961781 31586073 26496610
VAPB SNX2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
EP300 PCNA â—¼   PHYSICAL_INTERACTION 831.0 0.83 STRING 36370105
BRCA1 FANCD2 â—¼   UBIQUITINATION ✅ + 0.83 0.83 Signor 12485996
CCND1 EP300 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
EP300 VHL â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
GNL3 MDM2 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CFTR USP10 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
FANCD2 RPS27A â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
BRCA1 UBE2N â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
ABL1 RB1 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
NOC2L PES1 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
ABL1 EGFR â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
BRCA1 EZH2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 25531315 23624935
EGFR CD44 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 11606076 16565089 12093135 15597342 23265944
E2F1 E2F3 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 35140242 24981860 20106982
SNX2 EGFR â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 24797263 9819414
EGFR EMD â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 24797263 20937808 28065597
ELF3 EP300 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 35140242 15075319
CCNE1 CDK6 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 9716181 28628118 28205554
CFTR PSME2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 29924966 17110338
IPO4 KPNB1 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
DNMT3B EZH2 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
FANCI UBB â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
GNL3 RPL5 â—¼   PHYSICAL_INTERACTION 845.0 0.84 STRING 36370105
PES1 RPL5 â—¼   PHYSICAL_INTERACTION 845.0 0.84 STRING 36370105
ACTA1 ARPC3 â—¼   PHYSICAL_INTERACTION 845.0 0.84 STRING 36370105
CDKN1A EP300 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
HDAC6 UBB â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
ATM CREB1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16293623 17209043 15073328
CCNG1 MDM2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 12556559
CDKN1B CCNE1 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 34591612
SMAD4 TFE3 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 10557285 12551947
CFTR FAF2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 26618866 31324722 29924966
CFTR LMO7 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 26618866 29924966 17110338
CFTR AIMP1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 26618866 31324722 29924966
DNMT1 EZH2 â—¼   PHYSICAL_INTERACTION 849.0 0.85 STRING 36370105
CCND1 CDKN2A â—¼   PHYSICAL_INTERACTION 850.0 0.85 STRING 36370105
CDK6 CDKN1B â—¼   PHOSPHORYLATION ✅ - 0.85 0.85 Signor 16160006
EIF6 FBL â—¼   PHYSICAL_INTERACTION 851.0 0.85 STRING 36370105
GTPBP4 NOC2L â—¼   PHYSICAL_INTERACTION 851.0 0.85 STRING 36370105
MDM2 UBB â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
RPS27A ZRANB1 â—¼   PHYSICAL_INTERACTION 853.0 0.85 STRING 36370105
CDK6 PCNA â—¼   PHYSICAL_INTERACTION 856.0 0.85 STRING 36370105
E2F1 EP300 â—¼   PHYSICAL_INTERACTION 857.0 0.85 STRING 36370105
HDAC6 RPS27A â—¼   PHYSICAL_INTERACTION 857.0 0.85 STRING 36370105
PSMB4 PSME2 â—¼   PHYSICAL_INTERACTION 858.0 0.85 STRING 36370105
AHR RB1 â—¼   PHYSICAL_INTERACTION 858.0 0.85 STRING 36370105
ABL1 ERBB2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 22973453 16273093 19275932
BRCA1 RFC1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16713569 25184681 10783165
BRCA1 FLNA â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 22990118 20305393 16713569 26831064
SMAD4 EP300 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9679056 25514493 18215124 9843571 14612423 10887155 22033265
FANCD2 UBB â—¼   PHYSICAL_INTERACTION 859.0 0.86 STRING 36370105
MLH1 PCNA â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 15225546 32814904 28439008
ERBB3 HDAC6 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 20029029 31980649
HDAC6 ERBB2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 20029029 31980649
RAB5A AP1G1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 14665628 31980649
ERBB2 VAPB â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 26496610 24189400
EZR MISP â—¼   PHYSICAL_INTERACTION 0.86 0.86 HuRI 32296183
PSMB5 UBB â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
DNMT1 RPS27A â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
CREBBP MDM2 â—¼   PHYSICAL_INTERACTION 866.0 0.86 STRING 36370105
CDCA5 PDS5A â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
CDC25B YWHAE â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
PSMA3 UBB â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
PSMB4 UBB â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
BCAR1 ABL1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 7780740 8810278
SP1 BRCA1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 14710355 16713569 12706836 10720440 17766039
CFTR EMD â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 26618866 31324722 17110338
GNL3 PES1 â—¼   PHYSICAL_INTERACTION 869.0 0.87 STRING 36370105
HDAC1 VHL â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 22286234 11641274
CDK6 CDKN1A â—¼   PHOSPHORYLATION ✅ - 0.87 0.87 Signor 16508017
RB1 SP1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
BRCA1 CREBBP â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
FN1 VHL â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
CDKN1A MDM2 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
PSMB5 RPS27A â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
GTPBP4 RPL23 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
GNL2 RPL36 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
PCNA UBE2I â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
BCL2 FKBP8 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
EP300 MDM2 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
HIF1A MDM2 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
ATM BRCA1 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
CASP3 MDM2 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
NGFR TRAF6 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
ABL1 ATM â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
BRCA1 MLH1 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
FAN1 FANCD2 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
FAN1 MLH1 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
MDM2 RPL23 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
TRAF6 ZRANB1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
CCNE2 PCNA â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
DNMT1 DNMT3B â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
PELP1 TEX10 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
BRCA1 UBE2N â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 19712108 21965653 17873885
EP300 CCND1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15951563 10567390 11788592
E2F1 HDAC1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10734134 9468140 17980157 26468294 9468139
FKBP8 EGFR â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 20029029 31980649
AHR EP300 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10999956 17392787 21988832
SP1 EP300 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15647279 19062177 10651903 11517158 23714681 10899165 16478997 11030335 24530506 34252870 28425985 31536933 32115405 17623675 10362258 16734381 17906698 22415975 12200149
CDCA5 PDS5A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 21111234 15837422 26496610 31010829
PMS2 PCNA â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15225546 28439008 17148452
TEX10 PELP1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 21326211 22190735 33961781 24981860 26344197
CRK EGFR â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
CRKL EGFR â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
MDM2 RB1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
CTNNB1 HDAC1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
EP300 SMAD4 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
CCND2 CDKN1B â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
EIF6 GNL3 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
BCAR1 CRKL â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
CCNE1 RB1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
PCNA UBB â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
PARK2 UBE2N â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
BRCA1 ABL1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17352427 12024016
HDAC1 BRCA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 21102443 10220405 16713569
CCND1 BRCA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17334399 16713569 9244350
CDKN1B CCND1 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 34591612
CD44 ERBB2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11606076 28628118 12093135 17092940 28205554
EGFR CRKL â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 31980649 24658140 25402006 18271526 25754235 16729043 23397142
CREB1 EP300 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
MLH1 FAN1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 25659891 32296183 27880917 29051491 26496610 20603073 20603015 33961781 17148452
PCNA DNMT1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 20940144 20613874 24958773 9302295 26496610 30301766 12354094 23708667 22606318 10888872
BCAR1 CRKL â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 9498705 8810278 10753828 22974441 8978305 18835194
SP1 SMAD4 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10878024 18215124 21297662 16714330 11114293 22033265
GATA3 HDAC1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 29453984 34026424 26028330 31409898
HIF1A SP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12228247 17024177 17418410 15780936
DNMT1 EZH2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 31130994 16357870 22094255 28068325 21378168
VDAC1 VDAC3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 31536960 22939629 29128334 30021884
BAK1 BCL2L11 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
CDK6 CDKN1B â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
FANCI RPS27A â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
PSMA3 PSME2 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
ATM ABL1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9168116 17409407 10212258 20798688 11375976 9168117
CRKL ABL1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16443220 22286129 7493940 14604282 8978305 9820532 18835194 9710592 33961781 8524328 19823681 7926767 16955467 24412932
ABL1 EGFR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31980649 24658140 16273093 25402006 7678409
ABL1 MDM2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16702947 25624478 12110584
APC CASP3 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 10200466 17297457 9973322
SP1 ATF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 2145272 12760745
ATF2 RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18638549 15618023
ATF2 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23800081 10506225
ATM BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11114888 11278964 29656893 10783165 11016625 10866324 10550055 15713674 18344987 10608806 17478428
E2F1 ATM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22832221 23993922 12527885
PPP2CB ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15510216
BAK1 DBN1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
BCL2L11 BAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22492984 12242151
FKBP8 BCL2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15905180 15733859 17942410 12510191 17379601 33961781 15990872
CTNNB1 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17404573 16288908 12782598
E2F1 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11559537 18319725 11704823
BCL2L11 BCL2L2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 ACSN 23430059 23850759 9430630
BCL2L11 BCL2L2 â—¼   PROTEIN_INTERACTION 3.0 0.9 ACSN 23430059 23850759 9430630
E2F1 BCL2L11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23152504 19893569 16243973
BCL2L11 VDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12118373
EP300 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21102443 19887647 10655477 11782371 16713569 21212407 22787115
MLH1 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10783165 17148452 25184681 16786532 21240188 29656893
DNMT1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19943104 22197621 20631324
E2F2 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17106239
E2F3 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17106239
EZH2 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19079346 20574448
CASP3 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12149654
BRCA1 UBB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17873885 11320250 14636569
CFLAR CASP3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 9208847 9326610
CASP3 RFC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9235961 9351817
CASP3 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9348292
PCNA CCND1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15681588 7908906 8101826 33961781 7903056 21654808
NFKB2 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12808109 20420878 16990795
CDKN1A NGFR â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CREB1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25379405 14520699 21295542
HIF1A CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19342889 20138114 19940121
CREB1 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19340300
GATA3 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19340300
E2F1 BMI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23796898 17360938 16582100
E2F1 HSPA5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18840615
E2F1 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10914734 20837136
E2F1 SAFB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12629508
E2F1 DNMT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24502362 17575144 15867357
E2F3 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14576826 10766737 18319725
EP300 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10753885 15123636 15126619
SP1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10547281 8657141 10850422
ERBB3 EGFR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21278786 24189400 27756321 18803307 17148612 25315821 22439932 10527633 23436906 23866081 10572067
EGFR CRK â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16729043 9642287 31980649 10595738 22973453 24658140 11956190 16273093 9617486 25402006 12198159 8875975 9480911
EGFR HDAC6 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20029029 31980649 24658140 20133936 25402006
EGFR ERBB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11500850 25241761 30898150 17486068 11526509 9461599 23866081 17426253 10572067 11500516 24557338 8665853 15657067 19060928 16516204 19650109 20211985 25315821 23436906 21278786 25898135 32669362 1346931 24189400 21044682 18803307 16843263 28369073 7531698 16713569 17148612 21203579 17307140 1706616 16207817 7797556 12354693 11408594
GATA3 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19559773
EGFR BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17145710 17570479 15951569
PRKCA EMD â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 22986494 8463284 8034666
EP300 MDM2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15154850 20234175 16713569 11070080 9809062 28196907 15013777
EP300 PCNA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11268218 16713569 18263614 12937166 24939902 14988403 33742100
MDM2 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9809062 11070080 16713569
EP300 HDAC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15102857 19344692
GNL3 MDM2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 24769896 18426907 19033382 21132010
HDAC1 MDM2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15640443 33985974 12426395 30818224
HIF1A MDM2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12606552 10640274 25447306 15880652 19696166 25535359 17234751 15385570
PPP2CB MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11983168
PMS1 MLH1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 11292842 26496610 10748159 25502805 20004149 33961781 17148452
PPP2CB PRKCD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11959144
PRKCD CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 25639486
DNMT3B RASSF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19854132 12879017 18006804
TRAF6 UBE2N â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 18710948 17327397 15147900 17709375 21113135 27791197 19810754 24610907 29950522 27695001 27918549 31074699 34490261 18617513 30979779 25548215 11057907 19465916 29537486 31638574 15327770 19549727 31578830 27173435 28244869 29432170 23885119
HDAC1 PCNA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11929879 16189514 16713569 14988403
E2F3 PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15510213 18319725 11491305
CDK6 CCND2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 16713569 28628118 10022865 28205554 11360184 30217970 33961781 23602568 11358847 9178893
SP1 CDK6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12840223 11297539
FN1 CRK â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16581250 10777559 12640026
SP1 SMAD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21421563
SMAD4 FN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19516008 15525600 17452626
PTEN CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21385900
HIF1A HDAC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17273746 11641274 16511565 21148070 24015760
HDAC1 SP1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15647279 20072153 19062177 11909966 17894944 21636851 18003922 12176973 11896613 15557281 10409740 11517158 15713621 12665570 15722551 17906119 16478997 18850004 16121030 16883603 12091390 15155736 18948152 18059533 16713569 20385359 15528196 16734381 12200149 12847090
PRKCA CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11463380 17570479 20577053
SP1 NGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11839795 19114034 21123453
SP1 ABCC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9865734 23765166
VHL UBE2I â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 20844582 24002598 20300531
CTNNB1 ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15592430 10987283 12154096
DNMT1 DNMT3B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24423239 16481298 20155458
ELF3 ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11175365 12032832 12713734
E2F3 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18319725 14532106
GATA3 PDE3A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19559773
ABL1 CRKL â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
CDK6 CDKN1A â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
EP300 HDAC1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
GNL2 PES1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
GTPBP4 RPL36 â—¼   PHYSICAL_INTERACTION 902.0 0.9 STRING 36370105
CDK6 RB1 â—¼   PHYSICAL_INTERACTION 903.0 0.9 STRING 36370105
DNMT1 HDAC1 â—¼   PHYSICAL_INTERACTION 904.0 0.9 STRING 36370105
GNL2 RPL23 â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
EIF6 RPL38 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
PSMA3 RPS27A â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
PSMB4 RPS27A â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
GTPBP4 RPL38 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
GTPBP4 RPL27A â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
E2F2 RB1 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
E2F3 RB1 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
GNL2 RPL38 â—¼   PHYSICAL_INTERACTION 907.0 0.9 STRING 36370105
CCND2 CDKN1A â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
CDKN2A MDM2 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
PARK2 RPS27A â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
ERBB2 ERBB3 â—¼   PHYSICAL_INTERACTION 916.0 0.91 STRING 36370105
EP300 SP1 â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
CREBBP CTNNB1 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
CCND1 CDK6 â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
ERBB3 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 31862538
CDC25C YWHAE â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
SNX2 VPS26A â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
HDAC1 SP1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
FBL RSL1D1 â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
MDM2 RPL5 â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
RPS27A TRAF6 â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
BCAR1 CRK â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
HDAC1 RB1 â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
GTPBP4 NOC3L â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
NOC3L PES1 â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
ARAF MAP2K2 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
EIF6 PES1 â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
CTNNB1 EP300 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
DNMT1 UBB â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
ABCF3 GCN1L1 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
PES1 RSL1D1 â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
GNL2 RPL5 â—¼   PHYSICAL_INTERACTION 935.0 0.93 STRING 36370105
GNL2 RPL27A â—¼   PHYSICAL_INTERACTION 935.0 0.93 STRING 36370105
CCNE2 CDKN1B â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
BMF BCL2 â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 17289999 16697956 11546872
PCNA RPS27A â—¼   PHYSICAL_INTERACTION 939.0 0.94 STRING 36370105
CCND2 CDK6 â—¼   PHYSICAL_INTERACTION 939.0 0.94 STRING 36370105
EZH2 HDAC1 â—¼   PHYSICAL_INTERACTION 939.0 0.94 STRING 36370105
CDKN1A PCNA â—¼   PHYSICAL_INTERACTION 0.94 0.94 HuRI 32296183
APC2 CTNNB1 â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
CCND1 RB1 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
GTPBP4 RPL5 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
CDKN1A CCND2 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 16765349 5218735
ERBB2 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 5218411 16516204
RB1 HDAC1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 6550000 10779361
PRPF31 SF3A1 â—¼   PHYSICAL_INTERACTION 950.0 0.95 STRING 36370105
CCNE2 CDKN1A â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
UBB UBE2N â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
RPS27A UBB â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
PARK2 UBB â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
EIF6 RPL27A â—¼   PHYSICAL_INTERACTION 958.0 0.95 STRING 36370105
CTNNB1 APC â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 36950384
CCNE1 CDKN1B â—¼   PHYSICAL_INTERACTION 959.0 0.96 STRING 36370105
E2F1 SP1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 10850422 10409740 8657141 10547281 8657142
HIF1A EP300 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 17382325 5219810
CREB1 EP300 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 12665587 21268077 10506141 21212407 11313407 7870179 17476304 22787115 26944191 33846793
PCNA RFC3 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 12171929 24958773 12766176 14657243 10051561 9092549 26344197
EZH2 HDAC1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 16189514 21685935 15520282 10581039 24771265 31130994 22439931 26344197
RPS27A UBE2N â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
CCNE1 CDKN1A â—¼   PHYSICAL_INTERACTION 964.0 0.96 STRING 36370105
ABL1 CRK â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 31980649 9747873 11380621 15696159 8875975 9480911 21602891 18835194 18619508 12384576 8194526 11956190 19380743 24412932 9642287 17474147 8978305 12097319 17515907 33961781 12198159 7926767
CDK6 CCND1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15232106 16713569 10022865 24855949 17517622 33854235 11739795 14681455 24953629 11360184 33961781 10580009 17420273 21654808 11160398 9178893 19075005
RB1 E2F1 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 5219804 17380128
HIF1A EP300 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15280364 19589782 16543236 11823643 22807441 19666581 16189267 18047470 15342390 12042299 19680224 22735262 23448368 26135796 23618863 14691445 19696166 11959990 27320910 16847340 24821806 22789427 17906695 8917528 20620956 20000859 15261140 16081065 12778114 22219185 15154850 25192544 22075993 19071119 22908229 19940151 21187066 24421387 23880760 11940656 23966271 26826385 26944191 12588875 23746844 11063749 27808477 19074848 20603618 15155277 18268343 20829524 21148070 12914934 17502379 22684029 17382325 26751287
PCNA RFC1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 12171929 12192049 22939629 9649448 15225546 24958773 12045192 26496610 10353443 8861969 30301766 9092549 8999859 12400013 26344197
PCNA RFC4 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 9228079 12171929 16189514 22939629 24958773 26496610 10051561 12400013
HDAC1 DNMT1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 22274925 20613874 26794444 10615135 10888886 17707923 17934516 15870198 21670149 27593931 17967891 12473678 23708667
HIF1A VHL â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15082527 11865071 11226425 10944113 14556007 11986208 15527772 17973296 12538644 26735336 24899725 12606543 21358672 24015760 16611863 23401859 18062927 21332579 15805242 19940151 12086861 27281823 23413029 33060856 11292862 24316222 16155211 24857547 22932900 29121446 11292861 12101228 15060148 18047470 16278378 21602890 27320910 12464182 26611735 32589900 18402654 25500545 12050673 18694926 26215701 10878807 25361009 11641274 22351759 34007068 18305400 21316481 11024059 34195792 26037477 34174286 33039559 10823831 26743088 31810986 10353251 15833858 17558023 11566883 23580587 27563096 18985005 19123984 25438054 12682018 18323857 23387829 17442832 33550096 18222538 18426857 17047048 12004076 34230460 23318261 33961781 12808024 21335603 12586829 17353276 11358837 28514442 20724477 16140212 12205091 20049704 16862177 11331613 32535973 15721254 14691445 15385570 10973499 15611064 17981124 28775317 12925778 26496610 17339318 30237125 20458141 20639890 17986458 19147576 28425505 11504942 22369643 18264140 16511565 12351678 14600153 30988076 17132228
ERBB3 ERBB2 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 31862538
ERBB3 ERBB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 10799311 12896906 25241761 30523157 23680147 30898150 19411071 17426253 10572067 11173924 24557338 23866081 8665853 19060928 25326665 7592681 25315821 22733765 21075308 23436906 8816440 21278786 25898135 15812817 7538656 16843263 20227043 23688700 15504738 22806884 17148612 21203579 9130710
EGFR ERBB3 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
MDM2 RPS27A â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
DNMT1 PCNA â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
ABL1 CRK â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
MAPT PPP2CB â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
RFC1 RFC4 â—¼   PROTEIN_INTERACTION 0.98 0.98 HIPPIE 28514442 9488738 22939629 14681455 33961781 18245774 9092549 26344197
GTPBP4 PES1 â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
PRPF4 SF3A1 â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
DNMT1 RB1 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
CDK6 CDKN2A â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
EIF6 GNL2 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
EIF6 RPL36 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
CCND1 CDKN1A â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
EGFR ERBB2 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
EIF6 GTPBP4 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
CREB1 CREBBP â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
CCND1 CDKN1B â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
EIF6 RPL24 â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
RPL27A RPS27A â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
RPL38 RPS27A â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
RPL36 RPS27A â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
PMS2 MLH1 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 15225546 20706999 18206974 16338176 11793469 20533529 18768816 10037723 12799449 12810663 26496610 20978114 12584560 16083711 30770470 11292842 17581638 11429708 22939629 19015241 25077178 10748159 25502805 33961781 14676842 22252508 17148452
RFC3 RFC1 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 9488738 8692848 14681455 18245774 22939629 26344197
RFC3 RFC4 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 28514442 32296183 9488738 22939629 8692848 33961781 9092549 26344197
CRK BCAR1 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 31980649 9581808 22974441 15673687 10208419 12615911 10464310 15492270 12799422 18835194 8631823 10747099 11278916 16413489 10753828 16267043 10329689 19380743 10085298 14657239 27669437 17038317 9920935 11369773 11839772
GNL2 GTPBP4 â—¼   PHYSICAL_INTERACTION 989.0 0.99 STRING 36370105
TRAF6 UBE2N â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
RPL5 RPS27A â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
ELP3 IKBKAP â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
EIF6 RPL23 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
PSMA3 PSMB5 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
PSMB4 PSMB5 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CREBBP HIF1A â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
EIF6 RPL5 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPL23 RPS27A â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPL24 RPS27A â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPL23 RPL38 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPL23 RPL27A â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPL23 RPL36 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
PCNA RFC1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RFC1 RFC4 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PCNA RFC3 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PCNA RFC4 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPL36 RPL5 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPL38 RPL5 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPL27A RPL38 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPL24 RPL38 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPL24 RPL36 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPL27A RPL5 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL24 RPL5 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL36 RPL38 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL24 RPL27A â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL27A RPL36 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL23 RPL24 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
EP300 HIF1A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PSMA3 PSMB4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
RFC3 RFC4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
RPL23 RPL5 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ATM ABL1 â—¼   ENZYMATIC_REACTION ✅ 54.0 1.0 ACSN 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 9168117 9858600
ABL1 CRK â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 10837221 15459660 18835194 21051857 21199784 21435002
ABL1 BCAR1 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 10837221 15459660 18835194 21051857 21199784 21435002
ABL1 CRKL â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 10837221 15459660 18835194 21051857 21199784 21435002
ATM ABL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 44.0 1.0 Omnipath 17145710 17303408 22334513 11375976 11804596 23331499 21071413 16163361 17570479 18988627 9168116 23847781 9168117 20798688 15964794 19788416 9561848 22084676 12607003 10212258 15459660 11877377 15686624 17409407
PAK2 ABL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23331499 18161990 20841568 11121037
BRCA1 ABL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 12919958 12024016 17352427
ABL1 CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 100.0 1.0 Omnipath 8978305 9747873 9480991 19426560 17081983 23124138 16522685 16713569 20841568 18768933 8875975 25860930 21779437 19534553 16187300 17515907 21602891 16267043 20068231 10592173 17570479 8194526 7926767 11080615 25381819 12198159 9642287 15696159 18619508 18835194 11956190 22848689 11314030 9480911 19001122 19402756 20697350 12384576 24412932 7542925 11380621 12799422 19380743 12955086 17474147 17016520
ABL1 PRKCD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 18923184 17126298 9109492 16631755 19737086 28637715 20841568 10713049
ABL1 CRKL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 55.0 1.0 Omnipath 8978305 22581121 20841568 10837221 18768933 7493940 9710592 16955467 8524328 23331499 21199784 18794134 10592173 21051857 7926767 16443220 18835194 24165979 26500649 18809728 15459660 26192618 24412932 9053848 22286129 8083188 14604282 21435002 9820532 19823681
ABL1 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 32.0 1.0 Omnipath 23331499 12110584 20651945 29065514 22352870 16702947 25973395 27626309 21081495 27956626 20841568 14757045 19738896 15212693 28690977
ABL1 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 17254966 17908796 22276948 16195327
ABL1 BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 18083107 17129785 19534553 16212419 8810278 15951569 20841568 7780740
ABL1 DNM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17474147 20841568 19833721
ABL1 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 8242749 7828850 16158058 9071815 20841568
ABL1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 55.0 1.0 Omnipath 24430869 15192046 33889303 16273093 16943190 14760089 29880877 15618223 33574089 8910327 12631709 25173817 25402006 20841568 33947961 34107301 34469737 19915609 32019812 2022651 34290403 33707748 15329413 7678409 9733788 8490966 28338646 3263271 15901825 2022652 10069801 7506413 24658140 8408058 34385595 31980649 1314835 7741752 18668345 28724430 12648464 25073158 26079946 34155348
ABL1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 16099633 25164010 17618275 24465953 20841568 17318191 20840866
ABL1 SPTLC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 23629659
APC CTNNB1 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
APC CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 60.0 1.0 Omnipath 17145710 10545404 11166179 8259519 7890674 22083140 27902311 8638126 16212417 16798748 19061640 9286858 15327769 9482734 11533658 22056988 19576224 15327768 17318191 26496610 12628243 15355978 9065403 11712088 25241761 26910375 22682247 9065401 12000790 11707392 20219694 9707618 23840886 15525529 11251183 8628279 19631635 11972058 21664290
YWHAE ARAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 19608861 20936779 25852190 17979178
ARAF MAP2K2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 21988832 18039929 24746704 16189514 32296183 25852190 21779497 11909642
ATF2 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9990041 10915780 11850817 11410592 11739785 15691880 16405968 10464245 10500157 15314161 10066798
ATF2 FN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21479385 8335091 10471826 8703044 9151819
PRKCA ATF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 1661585 9436983 19176525 92095966
RB1 ATF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 1641004 11566021
PRKCE ATF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 24727247 22304920 24357804 25545367 26645581 25728676
SMAD4 ATF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10085140
ATM ATF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 24357804 25545367 15916964 28212892 25689427
BRCA1 ATM â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
MLH1 ATM â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9781043 16322221 16123081 11292842 10928988
ATM BRCA1 â—¼   ENZYMATIC_REACTION ✅ 54.0 1.0 ACSN 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 9168117 9858600
ATM FANCD2 â—¼   ENZYMATIC_REACTION ✅ 54.0 1.0 ACSN 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 9168117 9858600
ATM MDM2 â—¼   ENZYMATIC_REACTION ✅ 54.0 1.0 ACSN 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 9168117 9858600
MLH1 ATM â—¼   UP_REGULATES ✅ + 16.0 1.0 ACSN 12556884 15136767 15703371 16332722 16612326 16697054 16713580 16858402 17303408 17581638 18157157 18406444 18543256 19151707 19847258 20478261
PMS2 ATM â—¼   UP_REGULATES ✅ + 16.0 1.0 ACSN 12556884 15136767 15703371 16332722 16612326 16697054 16713580 16858402 17303408 17581638 18157157 18406444 18543256 19151707 19847258 20478261
ATM SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 23148884 18619531 22826432 27156884 29144413 29294106 23046908 17609267 18171990
ATM HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 27245613 24681585 21095578 18971907 21095582 27027353 23573973 27068951 25956861 23707302 26942179
ATM FANCI â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17412408 17525332 28636932 32117957
ATM E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 20972224 11459832 27679857 15494392 15140942 27028861 21543892 27025900 20860841 24741006 17570479 25101673 28812991 15838517 22174788
ATM EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 20471956 15494392 15140942 29590107 26170237 21108945 15838517 27220480
ATM FANCD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 16280053 17303408 15057286 12427531 15607958 25891850 16163361 21466974 20068231 14499622 17570479 12086603 19774700 23847781 14599770 15964794 22057367 28825622 12607003 17525332 15459660 16943440 15979372 11877377 27094386 15279770 28552166 12612651 19101576
ATM TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20932475 21872579
ATM MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 66.0 1.0 Omnipath 14654783 12383858 17936559 20651945 17303408 19816404 10611322 23150762 23277204 23386996 26416444 27258263 23002429 11331603 15865937 21556066 16163361 23708100 17570479 20514355 22264782 27177180 18265945 28690977 23847781 22264786 15140942 15964794 19788416 22624716 25201202 27462439 12607003 28050229 32350255 22649771 27956626 15459660 22976441 25247188 28904407 11877377 21859827 24534650 23405218 29290977 27568562
ATM CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 16293623 15073328 17525332 15212693 23642045 19115993
ATM RASSF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 31175105 22438769 19962312 27322327 10608806 22389451
ATM BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 79.0 1.0 Omnipath 26927092 17303408 15159397 24746700 12024016 10866324 30197789 12919958 11114888 26745677 26383678 34301763 12427729 11313470 16163361 28035057 20068231 25939603 26320175 17570479 19683496 22743550 10608806 23802008 23847781 21203981 15964794 12183412 12607003 17525332 19996295 15459660 11278964 19651622 21706030 11877377 20952512 10373534 19622773 10550055 27170701 15212693 23704879
BCL2 BAK1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 11704864 17446862 22039431 23064052 23377657 23430059 23850759 8929532
BCL2 BAK1 â—¼   PROTEIN_INTERACTION 8.0 1.0 ACSN 11704864 17446862 22039431 23064052 23377657 23430059 23850759 8929532
BCL2 BAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 17145710 9463381 14980220 11206074 17289999 26004684 11728179 20836993 19168699
BCL2L2 BAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17289999 18178565 25416956 10381646 15901672 32296183
BAK1 VDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9843949 10365962 10639121
BCL2 BMF â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 11546872 11704864 17446862 22039431 23064052 23377657 23430059 23850759 8929532
BCL2 BCL2L11 â—¼   PHYSICAL_INTERACTION 12.0 1.0 ACSN 10198631 11704864 15486085 15724238 17446862 22039431 23064052 23377657 23430059 23850759 8929532 9430630
BCL2 BCL2L11 â—¼   PROTEIN_INTERACTION 12.0 1.0 ACSN 10198631 11704864 15486085 15724238 17446862 22039431 23064052 23377657 23430059 23850759 8929532 9430630
BCL2 BMF â—¼   PROTEIN_INTERACTION 9.0 1.0 ACSN 11546872 11704864 17446862 22039431 23064052 23377657 23430059 23850759 8929532
PRKCA BCL2 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 10677502 10679481 10871288 11323415 16492141 20027184 9115213 9738012
SP1 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 14660675 20435036 12032828 10542244 15713621
E2F1 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17404573 11559537 12679318
CASP3 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 10409669 9395403 20139069 11948397
FKBP8 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 10409669 15990872 15733859 17942410 12510191 17379601 20139069
PRKCA BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 12039060 9115213 12213578 11323415 17610064 9738012 19117992 24212628 10677502
BCL2L11 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 38.0 1.0 Omnipath 17145710 9463381 16697956 9430630 17074758 17097560 19805519 18498746 26004684 14517273 10198631 21199865 20836993 26186194 15694340 17289999 17692808 11301022 23845444 21671007 9731710
PPP2CB BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15225643 9852076
BMF BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 16697956 11546872
CREBBP BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9829964 10753867 17565603 15337521 10454566
E2F1 BCL2L11 â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 11050388 11301023 11495903 14684737 15279786 17218262 17303408 17604722 17660363 18281283 18590585 19494111 7575488
E2F1 BCL2L11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17604722 11495903 11301023 18319725 19494111 11050388 18281283 14684737
BCL2L11 BCL2L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 17145710 9430630 16697956 15694340 17289999 21199865 9731710 32296183
BMF BCL2L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 25416956 32296183 11546872
PCNA BRCA1 â—¼   PHYSICAL_INTERACTION 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 E2F1 â—¼   PHYSICAL_INTERACTION 24.0 1.0 ACSN 10884389 11877377 12496474 15175241 15220350 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 18660752 19525936 19793801 20029420 20376879 21060331 21337561 24254977 7575488 7935440
BRCA1 FANCI â—¼   PHYSICAL_INTERACTION 55.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337601 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18448394 18472307 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 19995904 20029420 20173781 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 RB1 â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 11877377 15175241 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 19793801 20029420 21060331 21337561 24254977 7575488 7935440
BRCA1 FANCD2 â—¼   PHYSICAL_INTERACTION 69.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337601 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18448394 18472307 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 19995904 20029420 20081207 20173781 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
PCNA BRCA1 â—¼   SHARES_COMPLEX 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 RB1 â—¼   SHARES_COMPLEX 18.0 1.0 ACSN 11877377 15175241 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 19793801 20029420 21060331 21337561 24254977 7575488 7935440
BRCA1 E2F1 â—¼   SHARES_COMPLEX 24.0 1.0 ACSN 10884389 11877377 12496474 15175241 15220350 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 18660752 19525936 19793801 20029420 20376879 21060331 21337561 24254977 7575488 7935440
BRCA1 FANCD2 â—¼   SHARES_COMPLEX 69.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337601 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18448394 18472307 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 19995904 20029420 20081207 20173781 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 FANCI â—¼   SHARES_COMPLEX 55.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337601 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18448394 18472307 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 19995904 20029420 20173781 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 E2F1 â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 10884389 11877377 12496474 15175241 15220350 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 18660752 19525936 19793801 20029420 20376879 21060331 21337561 24254977 7575488 7935440
CREB1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9528858 19882681 18160048 23447579 11704836
SP1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15252835 17373631 18377656 19466541
E2F1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10660629 23285190 18660752 19466541 17106239 20068145 23108140
BRCA1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9926942 11394910 10196224 18025037 21245169 16735508 12647291
E2F1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9244350 18660752 18319725 11278247 12697828 16713569 12909625
BRCA1 FANCD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12887909 12485996 11239454 25652403 14499622 16713569
BRCA1 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11877377 21060331 19793801 21337561 15459660 20029420
E2F1 CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18660752 12389032 18319725
CASP3 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 25241761 9278461 21726810 24842904 9840926
CASP3 MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12888622 16606369 22535953 11162250
CASP3 BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 11511102 11447317 10712510
CASP3 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 25241761 9660939 10022118 9799125
CASP3 PAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9712143 9171063 11070003 9786869 16204230
CASP3 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 10822366 11420704 9092486
RB1 CCND1 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 Reactome 10207050 9447971 24876129 31543423 11416152 11032757 9190208 30711375 10499802
HIF1A CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23455892 20360945 20179204 15991006
SP1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 10497251 22911796 19850937 9236224 17617380 9407106 15870300 22415074 10850422 9584162 10908361 22734486 16267018 9637785 19755513 11410592 11024050 15922873 12794082 20435036 22334592
E2F1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 10504464 7929342 22768064 19876926 20220142 9584162 17998543 20655656 8618861 8137237 23078099 23543735 10594784
CTNNB1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 16628468 10318916 12095419 15111320 15735151 18679417 17360646 12782598 10201372 14557550 19778454 20300972 19662654 12589056 11943708 10915780 17693601 15592430 17109766
CREB1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 23447091 16503642 18957421 9990041 12504100 10915780 15116100 22271686 14764597 16522741 18713830 24065533 10201372 22751440 18988190 12391146
EP300 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 17306568 17666529 11788592 23343194 21285352 15576399 21151179 22761862 22290435 16039586 19619488 19623618 17143292
CDKN1B CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 17145710 9106657 10908655 17254966 25416956 7478582
CDKN1A CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 31.0 1.0 Omnipath 26203195 23443559 17145710 25416956 7478582 9837900 21988832 21516116 7777546 15232106 16082198 27107012 15695403 8657154 8242751 23007395 9106657 12383116 17556661 8756624 8662825 31515488
CDC25A CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 7575488 18590585 17303408 18073536 1075565 17568790 18786381 17660363 15279786
CTNNB1 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 19751508 10318916 7542250 11967263 22290435 11836555 19623618 12663502 23343194 11955436 22270359 22761862 16039586 15810077 10201372 19020303 17143292 12051714 17208333 8666229 18974774 16940750 14712077 17666529 21285352 19619488 15377999
CCND1 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 27.0 1.0 Omnipath 10498883 9315635 17303408 16236519 11520855 15279786 9190208 7575488 10385618 9736735 8490963 26225123 19237565 7736585 19075565 18590585 27507850 26121043 20068082 9425340 18786381 17660363 10778858 9380698 27430527
CCND1 CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 19075005 17517622 9178893 11739795 24855949 15232106 16713569 11360184 10580009 11160398
CCND1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 9190208 10498883 18590585 7575488 9315635 17303408 10385618 10778858 9736735 16236519 20068082 7736585 9425340 11520855 19075565 18786381 17660363 15279786
SP1 CD44 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11316768 15111490 21193408 12972613 16943418 18372343 18596044 10976926 12091390 12943729
CTNNB1 CD44 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18483247 12782598 17724465 10027409
FN1 CD44 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 1730778
E2F1 CDC25A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11154267 11799067 19633359
CDC25A CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 7575488 18590585 17303408 18073536 1075565 17568790 23429262 18786381 17660363 15279786
CDC25A CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 7575488 18590585 8617791 17303408 18073536 1075565 17568790 18786381 17660363 15279786
CDKN1A CDK6 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 14517297 17092340 9106657 18710949 24515438 20843055
RB1 CDKN1A â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 Reactome 10207050 9447971 24876129 31543423 11416152 11032757 9190208 30711375 10499802
E2F3 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17008321 10030670 22894933 17167174 15855772
SMAD4 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10878024 9618481 9865717 11786386 9307274 24052079 12429655 10962574 10415848
EZH2 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 21572997 21546904 24074410 21629038 22956625
DNMT3A CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20473858 15616584 16131836 24957603
E2F1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9748148 9191053 16923815 17008321 10030670 10702805 15048076 17167174
HDAC1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 12665570 19182791 15130752 18210215 16287849 17172847
HIF1A CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15071503 15190211 10559391 20043814 21362093
DNMT1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 21229291 21572997 19056828 16276353 9588214 21868513 23658227
EP300 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10362258 15509808 21858218 22000024 21245169
SP1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 101.0 1.0 Omnipath 9580699 15978937 15557281 11064455 16103879 19584258 20301197 20935676 15961274 15361832 11274368 11842244 15489892 15302882 10212208 12796485 23184467 14529564 12806965 9819384 10321829 10649433 12434298 18270969 18850004 16081043 9183012 21858218 10809237 9618481 16298343 11574165 10362258 11384995 15659839 14744793 10030670 17090534 10733944 19318349 12665570 18202149 17516505 15033443 22001409 17885207 10485470 9553133 15345676 15694838 22427654 17556661 10506225 23066038 15979845 18636159 14527674 24821727 15899840 14755691 12151347 24589735 18210215 23877711 11953011 21311948 15528212 15790310 10878024 22132221 12782287 12773551 8995437 21184768 12379120 17026958 24451377 10601254 8557703 16810128 16533812 7499379 10625687 15389873 16706751 12727210 21325288 16818630 18419600 15041706 23235480 19244234 15694666 23329847 18509005
MDM2 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17373842 25241761 20086099 14633995 14761977 20308078
CDK6 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 25121590 20102411 15964852 22375140 15232106 16713569 16508017 19440234
SMAD4 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9389648 9618481 17550342 12545156 11013220 15155580 11074002
SP1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17026958 9389648 9618481 17550342 12545156 11013220 15155580 11074002
PRKCA CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 17855660 10753973 11756412 15851482 16055744 15001356
CDKN1A CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 23443559 26186194 25241761 27107012 8756624 15169570 25416956 16765349 31515488 16189514 32296183
CDKN1A PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 67.0 1.0 Omnipath 23443559 25411249 20606006 8868473 15576034 16474839 25416956 20605778 16510448 18703516 23139781 11302688 11254741 26272819 16616141 21988832 11313979 7780738 17588519 12964161 25502805 10022118 8861913 16189514 26496610 16082198 8861969 17129767 18263614 26186194 22383522 22911014 7915843 7911228 27107012 23223023 17115032 32296183 19895794 18794347 19704162 10873631 9546435 8662825 31515488 21415862 9545252 11350925 12930846
CDKN1A RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 10498883 9315635 17303408 10486249 16236519 11520855 15279786 9190208 7575488 10385618 9736735 7736585 19075565 18590585 20068082 9425340 18786381 17660363 10778858 17556661
CDKN1A E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 9190208 10498883 18590585 7575488 9315635 17303408 10385618 10778858 9736735 16236519 20068082 7736585 9425340 11520855 19075565 18786381 17660363 15279786
CDKN1A CCNE2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 17145710 23443559 26186194 28514442 9840927 9840943 15232106 26496610 24358021
CDKN1A CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 17145710 23443559 31831640 21988832 9472014 17293600 11438644 9380407 12839982 16765349 9632134 25241761 8891332 9660939 8242751 9218599 11477082 8756624 8662825 8637717 9716181 13678583
RB1 CDKN1B â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 Reactome 10207050 9447971 24876129 31543423 11416152 11032757 9190208 30711375 10499802
SP1 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 9349726 12907235 18355800 10072762 19145069 21131823 22415074 15064717 15951157 16105842 23184467 15899840 12773549 12907249 10542271 16518840 11231912 19433067
E2F1 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15713665 21840777 22955272 23393547 19077036
CCNE1 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 17145710 31831640 8978686 8684460 17293600 9632134 17254967 9311993 20837141 27175940 9488039 25241761 8891332 9660939 7753174 19470470 9218599 12529437 9192873 8756624 17254966 12501191 9891079 10393546 9716181 11940657
CDK6 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 16160006 25241761 18615582 16782892 21439954 11360184
SGK1 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 42.0 1.0 Omnipath 26344141 15057270 26223520 12244303 15743786 23707388 19118035 20338997 11154281 18519679 26684356 33316141 12244302 15280662 27197201 18593906 25684140 18925875 24949832 17934340 11500365 18636226 20966355 15579463 16790529 21715331 26701207 19584721 20832730 12244301 18570873 21531565 22139837 23230143 18710949
YWHAE CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 14504289 16189514 12042314
CCNE2 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17254966 9840927 9858585 9840943
CDKN1B CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 25910212 16189514
CDKN1B CCNE2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17254966 9840927 9858585 9840943
CDKN1B CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 29.0 1.0 Omnipath 17145710 31831640 8978686 8684460 17293600 9632134 17254967 9311993 20837141 27175940 9488039 25241761 8891332 9660939 7753174 19470470 9218599 12529437 9192873 8756624 17254966 12501191 9891079 10393546 9716181 11940657
EP300 CDKN2A â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 32284348 19273602 32601262 10821856 28985506 33043019 31597407
CDKN2A CREBBP â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 32284348 19273602 32601262 10821856 28985506 33043019 31597407
BMI1 CDKN2A â—¼   DOWN_REGULATES ✅ - 7.0 1.0 ACSN 15640618 17936558 20818389 21383063 21678481 21685941 22796940
E2F3 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18663357 15175242 11883935 19340300
SP1 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10649433 22025288 15067344 17370299 21830402 17225865 12134028 19115249 16239970
E2F1 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 11314038 12766778 20664976 10914734 16211008 10594030 11062467 11705881 11526499 15716352 19641316 21765927 22621932 19115249 11870517 12695664 20580656 15175242 17912037
EZH2 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19954516 21572997 23289480 23826727
DNMT3B CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23397112 18006804 22461910 17149367 21757290
DNMT3A CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 26350239 19786833 20620135 17490527
E2F2 CDKN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18319725 11883935
E2F3 CDKN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15177020 15175242 18319725 11883935
E2F1 CDKN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11314038 16135794 11883935 12446760 18319725 15175242 11034215
BMI1 CDKN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 21383063 9308237 21678481 17936558 22796940 20818389 11283613 15640618 19404261 21685941
CDKN2A MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 57.0 1.0 Omnipath 12167711 18541670 23416275 9529249 17426254 12630860 17116689 12085228 15856024 10822382 19166854 12209154 12740913 17158541 16915296 17909018 25809483 9653180 14612427 22120712 16173922 10871849 18418067 24769896 9724636 21133853 10801444 19049976 9529248 16107876 18813780 20713054 18467333 15355988 18583933 20395212 11223036
CDKN2A CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 17881001 26186194 23602568 9751050 11739795 11556834 9380698 15232106 16713569 17955473 10491434 16915296 17909018
HIF1A DDIT4 â—¼   ENZYMATIC_REACTION ✅ 66.0 1.0 ACSN 10102273 10428030 10428780 10435632 10804084 10823814 11557773 11559532 11744734 11756417 11884613 12402042 12676992 12743597 14672622 14684737 14699081 14762718 15024076 15059920 15199147 15240700 15312748 15369676 15379897 15545625 16110315 16126909 16127144 16517405 16517406 16585195 16782875 16888645 17143338 17418790 17533374 17785433 18054315 18056423 18158893 18718909 19211554 20028863 20427344 20535745 20855962 21051947 21765015 22006996 22841746 22850421 22988108 24006507 25043024 25103413 25732824 7493931 7500013 7508926 8089148 8702901 8955077 9486205 9525945 9707622
HIF1A DDIT4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19828020 17307335 20176937
E2F1 RB1 â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 11877377 15175241 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 19793801 20029420 21060331 21337561 24254977 7575488 7935440
E2F1 RB1 â—¼   PROTEIN_INTERACTION 18.0 1.0 ACSN 11877377 15175241 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 19793801 20029420 21060331 21337561 24254977 7575488 7935440
E2F1 RB1 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 11877377 15175241 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 19793801 20029420 21060331 21337561 24254977 7575488 7935440
SP1 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9054613 12697671 10446910 18440323
E2F3 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14576826 7958836 12063292
E2F1 PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 7623816 12782299 14618416 20580656 9389735 11133765 8903355 9649317 23078099 12468739 1261188
E2F1 CCNE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 21653699 19564413 20220142 23518498 8668155 7623816 1059478 14618416 20410059 12565705 17471231 23543735 10594784 24335704 22185819 21454377 11526499 10504464 8618861 8649818
E2F1 RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 11533237 16081466 16738312 16188218 15618023 14681231 16230367 15985428 8264596 18583990 16601104 14627987 15016799 11268000 10490838 11818069
RB1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 90.0 1.0 Omnipath 17145710 23472054 12502741 22078878 8896460 12397079 9315635 20839231 16249186 11839806 8255752 11713253 20871633 15837424 8346196 19249677 16360038 8626527 12096339 15485814 16374512 18391203 9125176 16766265 9468140 8816798 12598654 10393912 9400991 9632788 12947005 19477924 15485920 17380128 10523633 10869426 7828850 18216119 8657117 12963846 25257171 17488475 28074012 15670817 11583618 7739537 10499802 8413249 11090181 8230483 22768064 29521627 10207050 9553123 7958924 11420730 23001041 16496386 9501179 19058874 1388726 9422723
CDK6 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 9190208 10498883 18590585 7575488 9315635 17303408 10385618 10778858 9736735 16236519 20068082 7736585 9425340 11520855 19075565 18786381 17660363 15279786
CCND2 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 9190208 10498883 18590585 7575488 9315635 17303408 10385618 10778858 9736735 16236519 20068082 7736585 9425340 11520855 19075565 18786381 17660363 15279786
CCNE1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 7575488 18590585 18687693 9315635 17303408 17660363 12006580 11420722 15279786
CREBBP E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10753885 15126619 12748276 15123636 8932363
NDN E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 24392139 9422723 14593116
E2F1 PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15510213 18319725 11491305
E2F1 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18319725 14532106
SP1 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 1282800 17616668 18575762 19538880 15665278 18202149 20435036 21705183 18007664 21464950 23821666 15533438 9819401 10830317 8393457 16087726 20407012 18391986
PRKCE EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 33.0 1.0 Omnipath 11447289 21749319 8321321 11313945 12359306 25402006 12040186 23830194 6321473 1860884 27016036 6090944 19568798 14585353 17496910 21386996 17942932 20692258 24658140 1556153 2984676 18042729 11940581 11185568 19615955 2987962 23205726 12845332 10816576 3379075 15567848 16488589 16793002
PRKCD EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 11447289 8321321 11313945 12040186 15302935 6321473 1860884 6090944 19568798 14585353 17496910 21386996 2984676 11940581 85012702 19615955 2987962 12845332 3379075 15567848 16488589 17956904
PTEN EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16288286 10648629 17218262 12040186 15584861
PRKCA EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 39.0 1.0 Omnipath 11447289 8321321 11313945 25402006 12040186 20888375 15302935 6321473 1860884 12878187 6090944 19568798 14585353 17496910 21386996 24658140 2984676 11940581 31980649 15212693 85012702 19615955 2987962 12845332 3379075 7805884 10816576 15567848 16488589
EGFR CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 32.0 1.0 Omnipath 19104148 27401557 15371335 16099633 22558232 30747223 12040186 26509276 24816560 12740122 25500543 17318191 19568798 21423209 14585353 34227224 23640056 17496910 17052462 24240237 25164010 14517306 21903109 22200182 16952352 20858269 28035485 9233779
EGFR CRKL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 31980649 23397142 18271526 24658140 25402006 16729043
EGFR EZR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 1382070 31980649 24658140 12560083 9230083 15212693 10377409 15647376
EGFR ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 17145710 23436906 7929151 21278786 24189400 23866081 17148612 12648464 27756321 18803307 10527633 10572067 22439932
EGFR ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 65.0 1.0 Omnipath 17081983 16207817 21044682 17148612 24557338 16713569 21203579 10233167 20471394 17389395 17486068 21278786 11500516 11279155 11500850 17426253 16843263 19650109 25241761 24189400 15657067 17307140 18803307 1706616 12354693 10572067 24355130 11408594 19060928 12648464 16516204 15951569 23436906 20211985
EGFR CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 52.0 1.0 Omnipath 10595738 9480991 16273093 9617486 25402006 17399949 8662907 8875975 21602891 20068231 8194526 12198159 9642287 11956190 24658140 26656091 9480911 31980649 15212693 26473374 16729043 17016520
EGFR ARF4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12446727
EGFR HDAC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 20133936 31980649 22896792 20029029 24658140 21151618 25402006 23084749
EGFR PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 21220489 24655521 23542172 29140271 28157503 26725162 22238610 25825764 17115032 26719139 28102297 22692198 28666590 25073158 20670598 20587074 23593472 25675097
PCNA EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 18263614 11268218 16713569
PRKCD EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 11020388 17434128 12379484 15006641 18053091 15212693 12590608
EP300 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 9843571 19419955 22033265 9679056 21269274
EP300 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 75.0 1.0 Omnipath 24821806 12573436 17145710 16847340 12588875 19589782 11940656 25192544 11959990 18519678 23448368 22219185 11823643 12042299 15342390 23746844 19071119 19680224 27808477 15154850 19696166 8917528 17906695 18268343 22735262 21148070 15261140 19940151 23880760 22807441 35430356 14691445 12914934 20000859 12778114 26751287 16081065 22789427 16543236 24421387 17382325 17502379 22684029 21187066 19074848 23618863 23966271 20603618
EP300 CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17306568 17666529 23343194 21285352 15576399 21151179 22761862 22290435 16039586 19619488 19623618 17143292
EP300 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11050151 18987336 15806138 15060161 17410209
FANCD2 FAN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20603015 21331524 25135477
PCNA FANCD2 â—¼   PHYSICAL_INTERACTION 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
FANCD2 FANCI â—¼   PHYSICAL_INTERACTION 66.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14614141 14624239 14726013 15242590 15375219 15377654 15459660 15485915 15703371 16337601 16337602 16697054 16713580 16818604 17303408 17349954 17965729 18082604 18082605 18085520 18087292 18448394 18472307 18543256 18584027 18809224 18931676 18995830 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 19995904 20029420 20064462 20173781 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
PCNA FANCD2 â—¼   SHARES_COMPLEX 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
FANCD2 FANCI â—¼   SHARES_COMPLEX 66.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14614141 14624239 14726013 15242590 15375219 15377654 15459660 15485915 15703371 16337601 16337602 16697054 16713580 16818604 17303408 17349954 17965729 18082604 18082605 18085520 18087292 18448394 18472307 18543256 18584027 18809224 18931676 18995830 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 19995904 20029420 20064462 20173781 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
FANCG FANCD2 â—¼   UP_REGULATES ✅ + 35.0 1.0 ACSN 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 8020957
FANCG FANCD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 22615860 19622404 12972610 23253856 15136767 19282663 14988723 8020957 24095737 18931676 22266823 16697054 24089143 23444773 19772495 19847258 18550849 21948210 22657828 20832754 19686080 12535671
FANCI FANCD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 21719678 22855611 24451376 17460694 27773793 20603015 25168188 19561358 18931676 24623813
FANCG FANCI â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 8020957
FANCG FANCI â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 22615860 19622404 12972610 23253856 19282663 8020957 24095737 18931676 22266823 16697054 24089143 23444773 19772495 19847258 18550849 21948210 22657828 20832754 19686080 12535671
PCNA FANCI â—¼   PHYSICAL_INTERACTION 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
PCNA FANCI â—¼   SHARES_COMPLEX 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
LRRK2 MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 22924508 24113872 26123245 24165324 25977830 22303461
SGK1 MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 15650334 17570479 16982696
HDAC1 MDM2 â—¼   PHYSICAL_INTERACTION 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
HDAC1 MDM2 â—¼   SHARES_COMPLEX 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
HDAC1 MDM2 â—¼   DOWN_REGULATES ✅ - 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
UBE2I MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15169778 15340381 15147722 12820959 10722742 19459846 18006823 10721693 19440234
MDM2 UBB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19805293 22056774 17290220
MDM2 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 15880652 25535359 12606552 25447306 17234751 19696166 10640274
MDM2 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 16374512 21990374 7791904 28615518 33185004 20871633 10078201
PCNA MLH1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 20154325 22118461 11274057 23840062
MLH1 PMS1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 ACSN 15703371 16612326 16697054 18157157 18406444 19847258 20478261
MLH1 PMS2 â—¼   PHYSICAL_INTERACTION 40.0 1.0 ACSN 10882712 11900249 12556884 12648680 12947387 15136767 15703371 16332722 16612326 16697054 16713580 16858402 17036055 17303408 17581638 17884153 18157157 18406444 18543256 18931676 19151707 19473888 19595721 19596235 19596236 19622404 19686080 19805513 19809470 19847258 20173781 20478261 21376743 22101340 22257761 22373527 22743550 22824526 23085398 24050180
MLH1 PMS2 â—¼   PROTEIN_INTERACTION 40.0 1.0 ACSN 10882712 11900249 12556884 12648680 12947387 15136767 15703371 16332722 16612326 16697054 16713580 16858402 17036055 17303408 17581638 17884153 18157157 18406444 18543256 18931676 19151707 19473888 19595721 19596235 19596236 19622404 19686080 19805513 19809470 19847258 20173781 20478261 21376743 22101340 22257761 22373527 22743550 22824526 23085398 24050180
MLH1 PMS1 â—¼   PROTEIN_INTERACTION 7.0 1.0 ACSN 15703371 16612326 16697054 18157157 18406444 19847258 20478261
MLH1 PMS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 45.0 1.0 Omnipath 25077178 17145710 10748159 17148452 11429708 18206974 19015241 16338176 20706999 15225546 25502805 19022408 12584560 26496610 14676842 16083711 11793469 10037723 11292842 22252508 17581638 12799449 18768816 20533529 31515488 20978114 12810663
PRKCD FSCN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 19651622 8647875 8999969 20068231
PCNA RFC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 8999859 12400013 15225546 19285992 10353443 12192049 9649448 26496610 12045192 12171929 24958773 8861969 9092549
SGK1 CREB1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 15733869 2052361 18088355 10826704 7608156
SGK1 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 11175347 12356771 15733869 8887554 9528766 11018520 11698596 11160957 11969286 12235136 7958915 9829964 9687510 18088355 11909979 8688081
UBE2N TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 18710948 1551980 17327397 11057907 15147900 18981220 21113135 17709375 31074699 19549727 18617513 24610907 27791197 29432170 19465916 23885119 15327770 27173435 21872579 25548215
UBE2N PCNA â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 10880451 16224103 16518696 17652783 18157158 18196958 18525240 18647995 19217833 19258535 19851286 20675655
UBE2N PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 18772547 12820959 18525240 19459846 19258535 19440234 17652783 15147722 10880451 15169778 19851286 10722742 18647995 18006823 18157158 16224103 20675655 16518696 18196958 15340381 10721693
E2F2 PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15510213 18319725 11491305
PCNA DNMT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 17991895 18384127 31235252 28073635 12354094 9302295
RB1 CDK6 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 Reactome 10207050 9447971 24876129 31543423 11416152 11032757 9190208 30711375 10499802
CCND2 CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10477583 17517622 16713569
CDK6 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 43.0 1.0 Omnipath 10498883 9315635 17303408 11416152 15081408 16236519 19690332 16936279 11520855 16107892 19413330 15279786 16360038 9190208 14627988 7575488 24417566 8822197 10385618 9736735 9139732 7736585 19075565 29372101 18590585 27507850 22682621 20068082 9425340 25549286 18786381 17660363 15809340 27811360 10778858 9380698
CDK6 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 17208333
CRK CRKL â—¼   PHYSICAL_INTERACTION 84.0 1.0 ACSN 10022831 10086337 10426994 10567412 10811803 10849428 10982827 11062502 11166270 11335727 11353765 11385609 11447289 11449354 11526404 11532940 11579131 11687500 11777939 11907067 11960372 12175651 12393695 12629515 12640133 12670391 13678960 15099563 15111329 15169881 15308668 15501236 15520864 15536084 15567848 15573129 15574420 16000375 16002046 16076871 16530705 16572188 16582911 16713974 16887996 17086423 17397400 17496910 17673906 17883421 18250477 18287025 18835194 19109239 19414323 19449109 19454690 19909365 20189481 20805416 21149606 21372296 21826665 22064427 22461508 22464172 23087689 23390297 23523669 24217602 24346288 24751819 24795729 25922287 25960930 26201938 26552706 7682895 8551221 8837607 9157999 9314552 9570538 9753319
CRKL BCAR1 â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 10426994 11062502 11353765 11385609 11447289 11526404 11579131 11687500 11907067 12670391 15169881 15308668 15536084 16000375 16076871 16713974 17397400 18250477 18287025 18835194 19109239 19454690 19909365 20189481 20805416 21149606 21826665 22464172 23087689 23523669 24751819 24795729 25960930 7682895 9314552
CRK CRKL â—¼   SHARES_COMPLEX 84.0 1.0 ACSN 10022831 10086337 10426994 10567412 10811803 10849428 10982827 11062502 11166270 11335727 11353765 11385609 11447289 11449354 11526404 11532940 11579131 11687500 11777939 11907067 11960372 12175651 12393695 12629515 12640133 12670391 13678960 15099563 15111329 15169881 15308668 15501236 15520864 15536084 15567848 15573129 15574420 16000375 16002046 16076871 16530705 16572188 16582911 16713974 16887996 17086423 17397400 17496910 17673906 17883421 18250477 18287025 18835194 19109239 19414323 19449109 19454690 19909365 20189481 20805416 21149606 21372296 21826665 22064427 22461508 22464172 23087689 23390297 23523669 24217602 24346288 24751819 24795729 25922287 25960930 26201938 26552706 7682895 8551221 8837607 9157999 9314552 9570538 9753319
CRKL BCAR1 â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 10426994 11062502 11353765 11385609 11447289 11526404 11579131 11687500 11907067 12670391 15169881 15308668 15536084 16000375 16076871 16713974 17397400 18250477 18287025 18835194 19109239 19454690 19909365 20189481 20805416 21149606 21826665 22464172 23087689 23523669 24751819 24795729 25960930 7682895 9314552
CRK CRKL â—¼   ENZYMATIC_REACTION ✅ 84.0 1.0 ACSN 10022831 10086337 10426994 10567412 10811803 10849428 10982827 11062502 11166270 11335727 11353765 11385609 11447289 11449354 11526404 11532940 11579131 11687500 11777939 11907067 11960372 12175651 12393695 12629515 12640133 12670391 13678960 15099563 15111329 15169881 15308668 15501236 15520864 15536084 15567848 15573129 15574420 16000375 16002046 16076871 16530705 16572188 16582911 16713974 16887996 17086423 17397400 17496910 17673906 17883421 18250477 18287025 18835194 19109239 19414323 19449109 19454690 19909365 20189481 20805416 21149606 21372296 21826665 22064427 22461508 22464172 23087689 23390297 23523669 24217602 24346288 24751819 24795729 25922287 25960930 26201938 26552706 7682895 8551221 8837607 9157999 9314552 9570538 9753319
CRKL BCAR1 â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 10426994 11062502 11353765 11385609 11447289 11526404 11579131 11687500 11907067 12670391 15169881 15308668 15536084 16000375 16076871 16713974 17397400 18250477 18287025 18835194 19109239 19454690 19909365 20189481 20805416 21149606 21826665 22464172 23087689 23523669 24751819 24795729 25960930 7682895 9314552
BCAR1 CRKL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 8978305 9498705 18835194 10592173 8810278 10753828 12345678 8943292 23770091
CRKL BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 8978305 9498705 18835194 10592173 8810278 10753828 12345678 8943292 23770091
SP1 EZR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21628504 19164283
PRKCA EZR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 14504278 15531580 10970850 11387207 21899702 15843435 9516463 15647376
CRK BCAR1 â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 11146654 11353765 12094222 12432077 14697347 15169881 15308668 16000375 16076871 18835194 19454690 20189481 22464172 9808620
CRK BCAR1 â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 11146654 11353765 12094222 12432077 14697347 15169881 15308668 16000375 16076871 18835194 19454690 20189481 22464172 9808620
BCAR1 CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 9920935 11369773 11278916 15673687 8662907 9581808 8631823 8070403 10747099 12065577 10329689 16267043 10592173 10208419 17038317 18835194 20627867 16413489 10753828 8943292 9860979 11839772 14657239 12799422 19380743 15492270 10085298 12615911
PRKCA FLNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12704190 21807941 24309511
SMAD4 SP1 â—¼   PHYSICAL_INTERACTION 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
SMAD4 SP1 â—¼   SHARES_COMPLEX 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
SMAD4 SP1 â—¼   ENZYMATIC_REACTION ✅ 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
UBE2I SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 21988832 31515488 16189514 15637079 16713569 12621041 29892012 15231748
UBE2I HDAC1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11960997 12032081 15199155 24068740
HDAC1 EZH2 â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 15465827 17018611 17563753 21234400 21577210 21685935 22514743 22796940
HDAC1 EZH2 â—¼   SHARES_COMPLEX 8.0 1.0 ACSN 15465827 17018611 17563753 21234400 21577210 21685935 22514743 22796940
HDAC1 BMI1 â—¼   UP_REGULATES ✅ + 22.0 1.0 ACSN 11283614 12545156 12668723 15151915 15155580 15465827 16232121 17055429 17508028 17550342 20027199 20713526 20818389 21234400 21733352 2191300 21919891 22370643 22796940 23140366 23869868 9618481
UBE2I HDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12820959 15340381 11960997
RHEB FKBP8 â—¼   PHYSICAL_INTERACTION 6.0 1.0 ACSN 12906785 17991864 18466115 19022819 19143635 23087689
RHEB FKBP8 â—¼   PROTEIN_INTERACTION 6.0 1.0 ACSN 12906785 17991864 18466115 19022819 19143635 23087689
RHEB FKBP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 18676370 18658153 17991864 19222999
CTNNB1 CREBBP â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 10769018 11050151 18160704 15060161 11973335 10775268
HIF1A CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12542982 20547241 17452336 15907483 19489936 15342390 15184875
SP1 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23297421 20096088 9765204 21191649 21464950 12200429 20130956 12169688 15576380 15184875 15713621 18571793
CREB1 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 47.0 1.0 Omnipath 10866654 18599546 15585582 7870178 8028671 11313407 16007092 8413673 11564156 15691881 9829964 15073328 20403362 11259575 17476304 17707401 20541704 16799563 7870179 11123304 27789289 7913207 12933667 8663317 8004670 11483993 12198160 9413984
CREBBP CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10769018 21751375 11973335 17410209 18347063 16476742 23273993
LRRK2 KPNB1 â—¼   PHYSICAL_INTERACTION 20.0 1.0 ACSN 10089876 10811803 10898494 11030334 11148124 11262396 11274345 11402342 11406367 14627704 17593948 17662023 18287025 19836308 21709260 21983832 7650486 8068174 9374532 9973469
LRRK2 KPNB1 â—¼   SHARES_COMPLEX 20.0 1.0 ACSN 10089876 10811803 10898494 11030334 11148124 11262396 11274345 11402342 11406367 14627704 17593948 17662023 18287025 19836308 21709260 21983832 7650486 8068174 9374532 9973469
LRRK2 KPNB1 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 10089876 10811803 10898494 11030334 11148124 11262396 11274345 11402342 11406367 14627704 17593948 17662023 18287025 19836308 21709260 21983832 7650486 8068174 9374532 9973469
HIF1A VHL â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
VHL HIF1A â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
HIF1A VHL â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 12205091 15930297 21887475 22150821 22396654 15962286 23159849 17482131 17140440 16883594
HIF1A ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12067980 20099200 17452336 19128456 17433259
VHL HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 123.0 1.0 Omnipath 17145710 21332579 24857547 12682018 26496610 11292861 11024059 15060148 16278378 12586829 17353276 12004076 12205091 17339318 10823831 11226425 21602890 16862177 15611064 12351678 16140212 11865071 26037477 16611863 10973499 23401859 25361009 11331613 18305400 25438054 14691445 17047048 12538644 22932900 18985005 26735336 21358672 18323857 10878807 19147576 16511565 17973296 23413029 24316222 11986208 12808024 12464182 23318261 22369643 19940151 15721254 20724477 21335603 16391536 23387829 18694926 26743088 14556007 18264140 10353251 15082527 11358837 11292862 11566883 12050673 19123984 17558023 27281823 15805242 11641274 25500545 34174286 24899725 12606543 32535973 17132228 24015760 12086861 11504942 35589690 26215701 22351759 12925778 18222538 17986458 14600153 10944113 23580587 26611735 18426857 20049704
RB1 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15674338
SP1 GH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 1427648 8754847 2181288 2659342 10698168 2033067
SP1 CYP1B1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12801909 23376040
SP1 ACTA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15933209
SP1 CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11160217 9339900 19753117
SP1 ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 18234965 7565762 10411657 23133566 10860921 9458366 17363581 7621073 8103518 10644769
SP1 AHR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 9778040 16410262 21569840 20478378
SP1 RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 18801742 12760745 8007947 1588949 17384411 21465530 15618023 7896792
SP1 FN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 15908479 16341057 9671487 1845987 8803927 2542772 7565693 15608673 9566920 1404598 2170405 10421838
SP1 BSG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22678117 20629990 21470566 20384626 24906624 11814679
AP1G1 DNM2 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10480952 7650016 7592972 10593899 14731593 2121367 9497313 8939989
DNM2 SH3GL3 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 16732277 16339507 25748042 17088212 29559111 17088211 9808461
AP1G1 DNM2 â—¼   GTPASE_REACTION ✅ 7.0 1.0 Reactome 10480952 7650016 7592972 10593899 2121367 9497313 8939989
PRKCA MARCKS â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1527003 7989336 9808756 11588141 8132675 17081983
PRKCA CFTR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 92316961 15212693 26888287 1377674
PRKCA MARCKS â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 79.0 1.0 Omnipath 17081983 20166139 18767875 17322306 1650359 11162562 1560845 19413330 19664995 8034575 6957862 21762971 18578522 91317794 20068231 11930178 18452278 17570479 16116087 18491316 18669648 17962038 8557118 17287340 15316066 8422248 19651622 20058876 15239673 17924679 2473066 19664994 18707149 18510355 15212693 18212344
PRKCA PDE3A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 24248367 25593322 19261611 16153182
PRKCA ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 17496910 11940581 21386996 11447289 19615955 16488589 6321473 8321321 12845332 11313945 18799465 9855018 12040186 19568798 15567848 14585353
CREB1 FN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 2170405 22357921 8648265 15908479 1845987 8803927 2542772 15608673 1404598 1320003 12372774
RB1 CCND2 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 Reactome 10207050 9447971 24876129 31543423 11416152 11032757 9190208 30711375 10499802
CTNNB1 CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17666529 23343194 21285352 18974774 22761862 22290435 16039586 19619488 19623618 17143292
CCND2 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 32.0 1.0 Omnipath 10498883 9315635 17303408 16236519 11520855 15279786 16326706 9190208 7575488 9003781 10385618 9736735 7736585 19075565 18590585 20068082 9425340 8449399 18786381 17660363 19651622 11254678 8343202 10778858
ERBB2 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 17496910 7702605 7999105 22558232 14517306 11245482 11950845 12040186 19568798 23576562 14585353 23640056
APC2 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23331499 23840886 10021369 8638126 16510875 10980707 10074433 9823329
ERBB2 ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 44.0 1.0 Omnipath 17145710 23680147 17148612 24557338 19411071 21203579 7592681 23688700 23331499 21278786 12648465 22806884 27531070 17570479 30898150 29066975 17426253 16843263 9130710 20227043 25241761 10799311 8816440 22733765 10572067 19060928 11173924 21075308 23436906 7538656 15504738
RAB5A RAB14 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 16522682 16154996 14617813 23519112
PRPF31 PRPF4 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
E2F2 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18319725 14532106
AHR CYP1B1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 17012224 9478971 19287966 17709388 23275542 21742528 12801909 19376845 17511620 19805408 12376470 12859982 18059014 17785579 14728982 19789301 16115918 10051545 21703235 24299737 22138065 22187486 19126602 12213569
CCNE1 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 7575488 18590585 9315635 17303408 17660363 12006580 11420722 15279786
CCNE2 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 7575488 18590585 10207050 9315635 17303408 19638577 17660363 12006580 11420722 15279786
E2F3 RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19015245 9711036 24287699 16449662
RB1 E2F3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 17380128 8657117 17488475 10779361 7739537 8832394
RB1 E2F2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 16360038 17380128 12502741 8657117 17488475 8246996 16189514 22569856 7739537 8832394