YWHAZ
|
H3C2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
19766566
8009287
|
H3C2
|
YWHAE
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
19766566
8009287
|
CCR1
|
FAN1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
28298427
20167430
|
YWHAZ
|
FSCN1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5217040
15161933
|
UBC
|
ICAM1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17174307
5219467
|
YWHAZ
|
KPNB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5217040
15161933
|
TRAP1
|
YWHAZ
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5217040
15161933
|
UBC
|
YWHAZ
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5217174
15324660
|
FAN1
|
CEP131
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.81
|
0.8
|
PKG
|
28854368
|
FAN1
|
PPDPF
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.81
|
0.8
|
PKG
|
28854368
|
MLH1
|
PMS2
|
â—¼ CORRELATES
|
|
+
|
0.81
|
0.81
|
CCLE
|
31978347
|
FACD2
|
FANCG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
18212739
31180492
|
FAN1
|
ZN703
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
27880917
25659891
|
PCNA
|
UHRF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
26496610
30357346
|
PMS2
|
FAN1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
27880917
20603073
26496610
25659891
17148452
20603015
|
FACD2
|
FAN1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
29051491
20603073
25135477
24794430
20603016
20603015
|
BLM
|
FACD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
15257300
25135477
31180492
|
FANCI
|
UBC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
843.0
|
0.84
|
STRING
|
36370105
|
PCNA
|
FACD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
19704162
25893307
31180492
|
MLH1
|
PCNA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
28439008
32814904
15225546
|
PCNA
|
UBC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
863.0
|
0.86
|
STRING
|
36370105
|
PSMD11
|
UBC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
868.0
|
0.86
|
STRING
|
36370105
|
FAN1
|
MLH1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
876.0
|
0.87
|
STRING
|
36370105
|
FAN1
|
FANCD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
876.0
|
0.87
|
STRING
|
36370105
|
PMS2
|
PCNA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
28439008
17148452
15225546
|
FAN1
|
GLB1
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
0.88
|
0.88
|
PKG
|
28854368
|
MLH1
|
FAN1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
33961781
27880917
29051491
32296183
20603073
26496610
25659891
17148452
20603015
|
MLH3
|
MLH1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
33961781
10615123
11292842
27229929
24443562
32814343
|
YWHAE
|
YWHAZ
|
â—¼ PHYSICAL_INTERACTION
|
|
|
899.0
|
0.89
|
STRING
|
36370105
|
H3C2
|
UHRF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
22064703
17673620
22348533
|
FANCI
|
FACD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
21719678
25168188
18931676
19561358
32510829
24794430
25319828
28684355
25489943
24451376
30456385
24623813
23993743
27773793
31180492
17460694
28575658
25862789
33795880
20603015
22855611
|
PMS1
|
MLH1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
33961781
25502805
10748159
26496610
20004149
11292842
17148452
16189514
|
YWHAZ
|
YWHAE
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.91
|
0.91
|
mint
|
20618440
7899808
|
BLM
|
MLH1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
941.0
|
0.94
|
STRING
|
36370105
|
FANCD2
|
UBC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
942.0
|
0.94
|
STRING
|
36370105
|
PMS2
|
MLH1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.99
|
0.99
|
HIPPIE
|
20706999
33961781
25502805
30770470
10748159
22939629
26496610
16338176
18768816
17148452
11793469
14676842
11429708
10037723
15225546
12799449
12584560
17581638
25077178
20533529
16083711
11292842
20978114
22252508
18206974
12810663
19015241
|
PCNA
|
RFC4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
996.0
|
0.99
|
STRING
|
36370105
|
PCNA
|
RFC3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
996.0
|
0.99
|
STRING
|
36370105
|
RFC3
|
RFC4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
PCNA
|
MLH1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
20154325
22118461
11274057
23840062
|
PCNA
|
FANCD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
PCNA
|
FANCI
|
â—¼ PHYSICAL_INTERACTION
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
PCNA
|
FANCD2
|
â—¼ SHARES_COMPLEX
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
PCNA
|
FANCI
|
â—¼ SHARES_COMPLEX
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
BLM
|
PCNA
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
12.0
|
1.0
|
ACSN
|
16697054
18931676
19622404
19686080
19772495
19847258
22266823
22657828
22973052
23253856
24089143
24095737
|
BLM
|
FANCG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
35.0
|
1.0
|
ACSN
|
12239151
12466554
12535671
12972610
14657033
14988723
15136767
15189446
16337602
16697054
17035102
18157158
18448394
18469862
18472307
18550849
18931676
19217833
19225445
19258535
19282663
19622404
19686080
19772495
19847258
20832754
21948210
22266823
22615860
22657828
23253856
23444773
24089143
24095737
8020957
|
BLM
|
FANCG
|
â—¼ SHARES_COMPLEX
|
|
|
35.0
|
1.0
|
ACSN
|
12239151
12466554
12535671
12972610
14657033
14988723
15136767
15189446
16337602
16697054
17035102
18157158
18448394
18469862
18472307
18550849
18931676
19217833
19225445
19258535
19282663
19622404
19686080
19772495
19847258
20832754
21948210
22266823
22615860
22657828
23253856
23444773
24089143
24095737
8020957
|
BLM
|
FANCI
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
35.0
|
1.0
|
ACSN
|
12239151
12466554
12535671
12972610
14657033
14988723
15136767
15189446
16337602
16697054
17035102
18157158
18448394
18469862
18472307
18550849
18931676
19217833
19225445
19258535
19282663
19622404
19686080
19772495
19847258
20832754
21948210
22266823
22615860
22657828
23253856
23444773
24089143
24095737
8020957
|
BLM
|
FANCD2
|
â—¼ UP_REGULATES
|
✅
|
+
|
35.0
|
1.0
|
ACSN
|
12239151
12466554
12535671
12972610
14657033
14988723
15136767
15189446
16337602
16697054
17035102
18157158
18448394
18469862
18472307
18550849
18931676
19217833
19225445
19258535
19282663
19622404
19686080
19772495
19847258
20832754
21948210
22266823
22615860
22657828
23253856
23444773
24089143
24095737
8020957
|
FANCD2
|
FAN1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
20603015
21331524
25135477
|
FANCD2
|
FANCI
|
â—¼ PHYSICAL_INTERACTION
|
|
|
66.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14614141
14624239
14726013
15242590
15375219
15377654
15459660
15485915
15703371
16337601
16337602
16697054
16713580
16818604
17303408
17349954
17965729
18082604
18082605
18085520
18087292
18448394
18472307
18543256
18584027
18809224
18931676
18995830
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
19995904
20029420
20064462
20173781
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22505525
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
FANCD2
|
FANCI
|
â—¼ SHARES_COMPLEX
|
|
|
66.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14614141
14624239
14726013
15242590
15375219
15377654
15459660
15485915
15703371
16337601
16337602
16697054
16713580
16818604
17303408
17349954
17965729
18082604
18082605
18085520
18087292
18448394
18472307
18543256
18584027
18809224
18931676
18995830
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
19995904
20029420
20064462
20173781
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22505525
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
FANCG
|
FANCD2
|
â—¼ UP_REGULATES
|
✅
|
+
|
35.0
|
1.0
|
ACSN
|
12239151
12466554
12535671
12972610
14657033
14988723
15136767
15189446
16337602
16697054
17035102
18157158
18448394
18469862
18472307
18550849
18931676
19217833
19225445
19258535
19282663
19622404
19686080
19772495
19847258
20832754
21948210
22266823
22615860
22657828
23253856
23444773
24089143
24095737
8020957
|
FANCG
|
FANCD2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
22.0
|
1.0
|
Omnipath
|
22615860
19622404
12972610
23253856
15136767
19282663
14988723
8020957
24095737
18931676
22266823
16697054
24089143
23444773
19772495
19847258
18550849
21948210
22657828
20832754
19686080
12535671
|
FANCI
|
FANCD2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
21719678
22855611
24451376
17460694
27773793
20603015
25168188
19561358
18931676
24623813
|
FANCG
|
FANCI
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
35.0
|
1.0
|
ACSN
|
12239151
12466554
12535671
12972610
14657033
14988723
15136767
15189446
16337602
16697054
17035102
18157158
18448394
18469862
18472307
18550849
18931676
19217833
19225445
19258535
19282663
19622404
19686080
19772495
19847258
20832754
21948210
22266823
22615860
22657828
23253856
23444773
24089143
24095737
8020957
|
FANCG
|
FANCI
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
20.0
|
1.0
|
Omnipath
|
22615860
19622404
12972610
23253856
19282663
8020957
24095737
18931676
22266823
16697054
24089143
23444773
19772495
19847258
18550849
21948210
22657828
20832754
19686080
12535671
|
MLH1
|
MLH3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
ACSN
|
15703371
16612326
16697054
18157157
18406444
19847258
20478261
|
MLH1
|
PMS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
ACSN
|
15703371
16612326
16697054
18157157
18406444
19847258
20478261
|
MLH1
|
PMS2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
40.0
|
1.0
|
ACSN
|
10882712
11900249
12556884
12648680
12947387
15136767
15703371
16332722
16612326
16697054
16713580
16858402
17036055
17303408
17581638
17884153
18157157
18406444
18543256
18931676
19151707
19473888
19595721
19596235
19596236
19622404
19686080
19805513
19809470
19847258
20173781
20478261
21376743
22101340
22257761
22373527
22743550
22824526
23085398
24050180
|
MLH1
|
PMS2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
45.0
|
1.0
|
Omnipath
|
25077178
17145710
10748159
17148452
11429708
18206974
19015241
16338176
20706999
15225546
25502805
19022408
12584560
26496610
14676842
16083711
11793469
10037723
11292842
22252508
17581638
12799449
18768816
20533529
31515488
20978114
12810663
|
YWHAZ
|
YWHAE
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
21988832
20936779
20618440
26496610
16376338
17979178
19766566
|
YWHAE
|
YWHAZ
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
21988832
20936779
20618440
26496610
16376338
17979178
19766566
|
PMS1
|
MLH1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.02
|
1.01
|
PKG
|
28854368
|
FAN1
|
ICAM1
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.09
|
1.09
|
PKG
|
28854368
|
FAN1
|
HMGCS1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.17
|
1.16
|
PKG
|
28854368
|
FAN1
|
CYP27A1
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.33
|
1.33
|
PKG
|
28854368
|
FAN1
|
SERPINB9
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.57
|
1.57
|
PKG
|
28854368
|
FAN1
|
LIMD2
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.59
|
1.58
|
PKG
|
28854368
|
FAN1
|
UHRF1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.75
|
1.74
|
PKG
|
28854368
|
FAN1
|
MID1IP1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-2.12
|
2.11
|
PKG
|
28854368
|
FAN1
|
RAB25
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
2.3
|
2.3
|
PKG
|
28854368
|
FAN1
|
GSTT2B
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
2.34
|
2.34
|
PKG
|
28854368
|
PMS1
|
PMS1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-7.89
|
7.88
|
PKG
|
28854368
|