Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
ABL1 ARHGEF11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PTGER4 ACTN4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
APAF1 CASP3 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 5214497 11550094
RRAS2 ARAF â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216198 12620389
AKT3 CASP3 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 17544405 5219985
CASP3 AKT1 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 17544405 5219985
CASP3 AKT2 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 17544405 5219985
CASP3 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17899380
CASP3 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9500443
CASP3 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17581882
TP63 CD44 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21930790 17935121
CD44 ARHGEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12748184 16189514
MAPK14 DDB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18806262
EGFR PTGS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19531499
EGFR ARF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24797263 20029029
EGFR ABCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12196520
EP300 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23403292 24998469
ESR1 EP300 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16704985 11279135
EP300 RELA â—¼   ACETYLATION ✅ 2.0 0.8 intact 5214468 11533489
MAPK14 NCOA3 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 16456540 5218295
MAPK14 FOS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18253836
NCOA3 MSH6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14966289 11747826
MYO6 TNFRSF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
NFATC2 IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17079331
FOS NFATC2 â—¼   PROXIMITY 2.0 0.8 intact 18172215 0705181105
TUBB6 TNFRSF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
ACTG1 TNFRSF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
CASP7 TNFRSF1A â—¼   COLOCALIZATION 2.0 0.8 intact 8095238 21157428
AR TP63 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21303954 20610535
IRF3 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6540704 18309294
IRF3 IFNA14 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19349300 11303025
ARPC2 ACTB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10592173 9600938
VASP ACTB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10592173 1318192
ACTB ARPC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10592173 9600938
AR APPL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12621049 20610535
CALM1 AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12799359 11988487
AR CALM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16619263 20610535
CALM1 ADCY8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16258073 10075700
ACTG1 TRAF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
CDK5 ACTR3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ARHGEF11 PLCG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
RRAS PLCG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
FCGR2A PLCG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7517665 8657103
FCGR1A PLCG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7517665 8657103
ABI1 PLCG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7907811 20598684
PLCG1 ALK â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18097461 9819383
PLCG1 AGTR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 9516477 6730883
TEC PLCG1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 11406363 15214048
TEC PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10823839 24317039
FOS SMAD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11854297
CREBBP SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9679056 9679060
SMAD4 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9679056 9679060
HES1 IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18976936 25733872
RELA PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14729949
PTEN AKT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 10644997
ESR1 HES1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18414489 19039095
HES1 NOTCH2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23037857 22172337
FGFR3 RELA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RELA NCOA3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16456540 5218295
RELA KITLG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19197368 14563684
PRKCZ RELA â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 12881425 5216561
FOS RELA â—¼   PROXIMITY 2.0 0.8 intact 18172215 0705181105
RELA FOS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16189514 10488148
ESR1 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23403292 24998469
CREBBP ELK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8941362
VAV2 RHOA â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 18589439 8990121
FOS RHOA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10085083 15068801
RHOA AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15884057 11748077
ANK2 NCK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
RRAS NCK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
DOCK1 NCK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
NCK1 PIK3CD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
NCK1 ARHGEF11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
FCGR2A VAV2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8986718 16546099
FCGR1A VAV2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8986718 16546099
IGF1R VAV2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11094073 17570479
AR PTGER2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12933667 20610535
ELK1 PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17505916 23818898
ESR1 PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19797124 20819530
VHL IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17486080 19509240
ARHGEF12 IGF1R â—¼   COLOCALIZATION 2.0 0.8 intact 11724822 5214835
RPS6KB1 AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5214238 11438723
ESR2 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16549430 17261755
NCOA3 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16877447 20305690
PRKCZ AKT1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 18650932 7232391
PTPRF AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15896785
FOS EDN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21239258 1918021
FOS NOTCH2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12208848 20876509
FOS VEGFD â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23157741 19136250
FOS EDN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9588211 16716598
FGFR3 WNT7A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FGFR3 KLHL20 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
AR CDK5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23941877 20610535
PRKCZ VHL â—¼   COLOCALIZATION 2.0 0.8 intact 5219754 17350623
ARHGAP1 RHOC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
GNA12 AKAP13 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14636890 11546812
GNA12 ARHGEF11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11799111 10026210
CACNA1C ACTN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
PRKCE ADCY7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17185372
PRKCE ADCY5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17185372
GNAQ AGTR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219925 17498700
GNA11 GNAQ â—¼   GTPASE_REACTION ✅ 2.0 0.8 Reactome 8073283 7937899
ADRA1B GNAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9481484 31160049
ADRA1A GNAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 31160049 1334487
ESR1 EDN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10432218 18414489
ESR1 WNT4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20126574
AR NRP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20739403 20610535
AR ABCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15520169 20610535
AR ESR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11371645 20610535
AR ADM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16376459 20610535
AR ADRA1D â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20610535 16964290
NCOA3 RAC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19305643 24918060
PLXNB1 RRAS â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 16702230 16799460
VASP PFN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
AGTR1 GNA12 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
RFXANK HLA-DOB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12938212 11258423
WNT2B LRP5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23209147 15578921
WNT10B LRP5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23209147 15578921
ADRA1A NTNG2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
CAV2 EGFR â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
KLHL20 CUL3 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 20389280 7900485
RPS6 RPS6KB1 â—¼   PHYSICAL_INTERACTION 810.0 0.81 STRING 36370105
NCK1 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 8662998 5221064
EGFR IGF1R â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17047074 17307140
EGFR ACTB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22366308 31980649
ACTB EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33742100 21988832
ESR1 MSH6 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 16260778 31527615
ESR1 RAP1A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19805454 31527615
PTPRF RHOA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31871319 25458010
NCK1 ABI2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33961781 26871637
AKT3 AKT1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
FOS ESR1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17317669 25303530
ESR1 CTBP2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23403292 31527615
CREB3 MYO5C â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
ARF6 CYTH3 â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
PLXNB1 RAC3 â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
ARHGEF1 RHOA â—¼   GTPASE_REACTION ✅ + 0.82 0.82 Signor 10836144
EGFR EPHA2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 24797263 15657067
ESR2 EP300 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 11500849 18765668
NFYB EP300 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 10075648 9799238 15454570
GAN CUL3 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 21145461 15983046 31944090
RHOC RHOA â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 31871319 33961781 31980649
KNG1 VHL â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
ESR1 ACTN1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 23403292 21182205 19805454 31527615
ESR2 ACTN1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 29509190 21182203 25604459
AKT1 MAPK14 â—¼   PHYSICAL_INTERACTION 830.0 0.83 STRING 36370105
EP300 VHL â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
IGF1R IGF2 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
ABL1 EGFR â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
EGFR CD44 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 11606076 16565089 12093135 15597342 23265944
EP300 FOS â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 19064921 21937452 11287611 24069158
ESR2 ACTB â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 21182203 21951318
ESR1 IGF1R â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10749889 24051437 14764897 28555617 16113100
EGFR PLCG1 â—¼   PHOSPHORYLATION ✅ + 0.84 0.84 Signor 1689310
ACTN4 ESR1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 21078666 19805454 25604459
PLCG1 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 9020117 6805619
ARF6 ARRB2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 11533043 16189514 11867621
CAV2 NCK1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16189514 12091389
AKT2 AKT1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 28514442 12149249 9736715 12176337 11445557 33961781 14500673 11278835 11546794
VHL EGLN1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 22286099 17986458 26215701
EP300 FOS â—¼   PHYSICAL_INTERACTION 850.0 0.85 STRING 36370105
CALM1 ESR1 â—¼   PHYSICAL_INTERACTION 850.0 0.85 STRING 36370105
AKT1 PTEN â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
ARHGEF11 PLXNB2 â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
CCNA1 FZR1 â—¼   PHYSICAL_INTERACTION 858.0 0.85 STRING 36370105
SMAD4 EP300 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9679056 25514493 18215124 9843571 14612423 10887155 22033265
PLCG1 ALK â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 11888936 9819383 14968112 9174053
AKT1 PTEN â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 12297295 19903340 12077256 28628118 20605778 28205554 10866658 20596030
ABI1 CYFIP2 â—¼   PHYSICAL_INTERACTION 859.0 0.86 STRING 36370105
ARHGAP35 RHOA â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
AKT1 APPL1 â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
AKT1 PRKCZ â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
EGFR PTPRF â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24797263 31980649 24189400
EGFR ARRB2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24658140 25402006 31980649
EGFR VAV2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24797263 10938113 11516622 19531499 22973453 12454019 10618391 18271526 20940296
AKT1 EP300 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 21901101 15224190 21775285 20333651 18182168 11116148
EP300 IRF3 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 12473110 11940575 9660935 11314014 20604809 9488451 21903422
ESR1 ACTB â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 31527615 20308691 19805454 21182203 21182205 20348541
RHOA ARHGEF11 â—¼   PHYSICAL_INTERACTION ✅ 0.87 0.87 mint 7909059 20300064
GIPC1 NRP1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 29755126 15978582 27481513 10414980
ABI1 ABI2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 32296183 33961781 26496610
AKT1 AR â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CACNA1S CALM1 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
CALM1 EGFR â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
ALK PLCG1 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
ARHGAP1 RHOA â—¼   GTPASE_REACTION ✅ - 0.87 0.87 Signor 32203420
ESR1 ESR2 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
BIRC2 TNFRSF1A â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
IL6 IL6ST â—¼   UP_REGULATES ✅ + 0.87 0.87 Signor 8511589
PPP3CB PPP3CC â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
ABL1 ABI1 â—¼   PHOSPHORYLATION ✅ + 0.87 0.87 Signor 21320496
CREBBP ESR1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
ABL1 PLCG1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10708759 1383690 17474147
ACTN1 ACTN4 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 22863883 22939629
ESR1 EGFR â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16713569 28065597 20935677 11887937 17284441
RAC3 ESR1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16331275 21217774
AR EP300 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
EGFR NCK1 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
EP300 SMAD4 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
BIRC2 TRAF1 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
AKT1 EP300 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
ACTR3B ARPC5L â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
EGFR ACTN4 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24658140 25402006 31980649 26320552
BIRC2 CASP3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16189514 17069460 9384571 11084335 19258326 11106668
EGFR AKT1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24658140 25402006 31980649
EGFR ARF6 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 34079125 24797263 20029029 31980649
VHL CUL2 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 6542648 18323857
ABI1 NCK1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 33961781 11557983 11418237
NCK1 RRAS â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17474147 10671570
CASP7 BIRC2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16189514 16339151 9384571 11084335 33961781 15580265 19258326
VASP ABI1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 32296183 16055720 26186194 34079125
FOS NFATC2 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
EP300 NCOA3 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
ARHGAP35 RHOA â—¼   GTPASE_REACTION ✅ - 0.89 0.89 Signor 32203420
CREBBP RELA â—¼   ACETYLATION ✅ + 0.89 0.89 Signor 16382138
CALM1 SLC9A1 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
ESR2 NCOA3 â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
ABL1 ABI1 â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 5219329 17101133
ABI2 ABL1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 17101133 7590236 12569093 33961781 27229929
ABL1 EGFR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31980649 24658140 16273093 25402006 7678409
ABL1 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19783996
BMP7 ACTR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 16446785
APC CASP3 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 10200466 17297457 9973322
RRAS2 ARAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17145710 12620389
AR CASP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22038727 20610535 23554843
EGFR RHOA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
NCK1 EGFR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31980649 9362449 24658140 10026169 8662998 16273093 25402006 1333047
EGFR CAV2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31980649 24658140 15273741 25402006 16799092
EGFR PLCG1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 1689310 11983899 14568990 15144186 12803489 12601080 24797263 9756944 9207933 19605547 7993895 7693694 9020117 12061819 16273093 25754235 16713569 22973453 7682059 8657103 8885868
RELA EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17881446 23379415
EP300 IRF3 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
EP300 NCOA3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16923966 10655477 9267036 23065768 16227615 20368990 11823864 10490106 25728767 33589584 10866661 15145939
EP300 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19887647 11782371 12738788 25728767 11867769 12479814 23065768 15308690 20388208 14761960 22227247 8799122 20348541 23403292 12714702 11581164 16713569 19838210 18765668 16645043 30418174 12574227
RELA MAPK14 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
GIPC1 MYO6 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 26971995 17353931 12857860 10198040 29467281 19855435 16908842
ESR2 TP63 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20034404
TP63 IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 27132513 8258457 23071313
RPS6KB1 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18769144
CREBBP IRF3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 ACSN 15265520 22331441 23422957
CREBBP IRF3 â—¼   PROTEIN_INTERACTION 3.0 0.9 ACSN 15265520 22331441 23422957
IRF3 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19349300 15355347 18309294
IRF3 IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20483755 27337441
CUL2 VHL â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16503656 22086907 28514442 9751722 10823831 15060148 11865071 21942715 27697924 20049704 26743088 11779168 17439941 12604794 9122164 21145461 15611064 19030229 21685897 12048197 10421634 28775317 15601820 10449727 24469044 11384984 10587522 18173839 22286099 17339318 16261165 16611863 23401859 15966899 22234250 9447969 17353931 26751167 18323857 25661653 33137104 11024059 18187417 18523483 10318914 26735018 24981860 33961781 31444342 26846855 17132228
ANK1 ACTB â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16904324 11222639 17223356
ACTB ANK2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16904324 11222639 17223356
NFYB ACTB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 1762920
CALM1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9859994 2550447 19608982
CALM1 CAMK2G â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10860555 20668654
CALM1 ADCY1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 2022671 7685187 8417150
ANK1 ACTG1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16904324 11222639 17223356
ACTG1 ANK2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16904324 11222639 17223356
ESR1 C3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10418989 8961270 17478088
AKT1 SMAD4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16362038 23397142
SMAD4 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12226080 16713569
PTGER2 IL6 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 21209948 22025564 25916550
CYTH3 ARF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18451304 9707577 10652516
RHOA ARHGAP35 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18829532 9407060 16308318
ARHGAP35 RHOA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15102857 12429740 16707504
ARHGAP35 RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15102857 10592173 32203420
FGB RAP1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16040750 14754902 10446041
RAP1A APBB1IP â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 17624957 15469846 16757337
RELA AGT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10628750 8833654 8613256
RELA AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16713569 8798655
ARHGEF11 RHOA â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 12220504 15210733 12730235
RHOA ARHGEF12 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 12220504 15210733 12730235
RHOA PFN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22820501 22479341 27228149
EPHB1 NCK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 9430661
VAV2 ARHGAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8994827 9032261 9822605
AR PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18386814 16317058
ESR2 FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20155458 10037443
FGF9 FGFR3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 14613973 8576175 10574949
CDK5 CORO1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 26823173
PRKCZ AKT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18353613 9512493
BIRC2 TRAF1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 11907583 16713569 21988832 20447407 9384571 8943045 25996949 33961781 23524849 16891304 30561431 8548810 21903422
ARHGEF11 RHOC â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 12220504 15210733 12730235
GNA13 ARHGEF11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11799111 10026210
RHOC ARHGEF12 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 12220504 15210733 12730235
GNA12 ARHGEF12 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12515866 11094164 12024019
AGTR1 GNAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17498700 31160049 11313903
RRAS2 PIK3CD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19561613
NCOA3 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 26153859 20392877 15383283 14766010 25728767 21182203 15145444 18484708 11376110 14966289 9346901 20181721 26166704 16331275 28844863 11389589 11050174 12630920 19491275 17158759 23403292 12714702 17646391 9192892 11353774 16923966 18645020 16713569 30418174 10490106 9765300 12554772 26487511
ESR2 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 29509190 12630920 17991765 21182203 19022902 10706629 19746436 9473491
ESR1 NOTCH2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19376833
ESR1 RPS6KB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22286763 21292829 18414489
NCOA3 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10965917 17108143 19305643
GNA13 ARHGEF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11313914 15951850 22661716
NCOA3 ESR2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11500849 11376110 17158759 10681591 21182203 12554772 9765300 11389589
ESR2 NOTCH2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19376833
FGB APBB1IP â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16040750 14754902 10446041
SRGAP3 SLIT2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16857672 11672528 21655271
WNT8A LRP5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23209147 15578921 32196115
IL6R IL6ST â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
ACTB ACTG1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HuRI 32296183
EGFR VAV2 â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
ARHGEF11 RHOA â—¼   GTPASE_REACTION ✅ + 0.91 0.91 Signor 32203420
ARHGEF12 RHOA â—¼   GTPASE_REACTION ✅ + 0.91 0.91 Signor 11094164
AKT1 ARRB2 â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 18191226 19122674 19262695
EGFR PLCG1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
EP300 RELA â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
GIPC1 MYO6 â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
CREBBP RELA â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
ESR1 NCOA3 â—¼   PHYSICAL_INTERACTION 929.0 0.93 STRING 36370105
EP300 ESR1 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
RPS6KB1 RPS6 â—¼   PHOSPHORYLATION ✅ + 0.93 0.93 Signor 15809305
ATP6V0B ATP6V0C â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
ARRB2 AGTR1 â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 11226259 11279203 15611106 28298427
AKAP13 RHOA â—¼   PHYSICAL_INTERACTION 940.0 0.94 STRING 36370105
ACTB PFN1 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
ABI1 ABL1 â—¼   PHYSICAL_INTERACTION 948.0 0.94 STRING 36370105
ACTG1 ACTB â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 8153045 21516116
GIPC1 ACTN1 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 10198040 16713569
ABI2 ABL1 â—¼   PHYSICAL_INTERACTION 950.0 0.95 STRING 36370105
ACTN1 ACTN4 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
CACNA1C CALM1 â—¼   PHYSICAL_INTERACTION 953.0 0.95 STRING 36370105
ACTR3B ARPC2 â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
C3 CR1 â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
ACTR2 ACTR3B â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
NCK1 ABL1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 11494134 17474147 10967110 12379115 10372803 7926767
ABL1 ABI1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 17101133 9593709 12672821 9010225 18328268 8943360 20598684 11418237
IL6 IL6ST â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
CREBBP NCOA3 â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
AR NCOA3 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
ARHGEF11 RHOA â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
ARHGEF12 RHOA â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
ARHGAP1 RHOA â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
ACTR3 ARPC5L â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
ACTR2 ARPC5L â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
ARPC2 ARPC5L â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
ABL1 NCK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 10372803 23331499 22327338 11494134 10967110 12379115 17474147 20841568 7926767
ABL1 CDK5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 19901323 26944284 15689152 19690332 16497976 24975575 19413330 20841568 18083107 19534553 20068231 19700222 9038181 14757045 23348931 11113134 10896159 18691976 28646794 29063113 24600352 12372285 19369195 18794154 15212693
ABL1 NCOA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18765637 20841568
ABL1 ABI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12569093 17101133 7590236
ABL1 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 10708759 19290927 12652307 1383690 16525023 8657103 20841568 17474147
ABL1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 55.0 1.0 Omnipath 24430869 15192046 33889303 16273093 16943190 14760089 29880877 15618223 33574089 8910327 12631709 25173817 25402006 20841568 33947961 34107301 34469737 19915609 32019812 2022651 34290403 33707748 15329413 7678409 9733788 8490966 28338646 3263271 15901825 2022652 10069801 7506413 24658140 8408058 34385595 31980649 1314835 7741752 18668345 28724430 12648464 25073158 26079946 34155348
ABL1 ARHGAP35 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15084284 20841568
ABL1 DDB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 12107171 20841568
ABL1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 20841568 20101225 30692633
ABL1 ABI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 48.0 1.0 Omnipath 17145710 20598684 18328268 12591740 9593709 20841568 18083107 7590237 11418237 12672821 17389395 19534553 8943360 17101133 9010225 11163214 26428302 21320496
ACTR2 ARPC2 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR2 ACTR3 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR2 ACTR3 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR2 ARPC2 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
CASP3 APAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12874265 21827945 11550094
RRAS ARAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10848612 12620389
MAPK14 CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 14970175 33176141 29414778
BIRC2 CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 9990849 12042762 9384571 17069460 11382748 11106668 16189514 11084335
CASP3 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 8626669 9535906 16713569 9208847
CASP3 NFATC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 16455648 17613518 19900451 9390557
CASP3 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 17544405 12124386 10579725
CD44 SLC9A1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 16104017 9712871 15090545 8901634 11350981 17050540 15035633
PTGS2 EGFR â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 18633355 20138012 21847358 23010081 23390297 25987127
AR EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 15305378 19318561 21613411 19258514 15650253 17242169 18692155 15288768 11556855 20610535
ESR1 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12894229 12421825 8200909 21705183
CAMK2G EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 3138233 10347170 16799092 1309762 7805884 7505275 92065884 15302935
PRKCE EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 33.0 1.0 Omnipath 11447289 21749319 8321321 11313945 12359306 25402006 12040186 23830194 6321473 1860884 27016036 6090944 19568798 14585353 17496910 21386996 17942932 20692258 24658140 1556153 2984676 18042729 11940581 11185568 19615955 2987962 23205726 12845332 10816576 3379075 15567848 16488589 16793002
MAPK14 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 15187187 18039929 19138820 7535770 12738796 17139251 16932740 23397142 16785992 11274345
AR EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18358509 12534934 22260327 15288768 18951974
PTEN EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16288286 10648629 17218262 12040186 15584861
EGFR PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 89.0 1.0 Omnipath 19901323 17081983 16273093 9207933 2472219 16497976 15592455 16126727 16713569 24797263 17389395 8578591 23331499 7991458 1689310 20068231 17570479 9176240 12803489 16153436 7993895 16038803 7805859 15864276 1708307 7682059 15144186 11983899 12601080 9756944 15212693 14568990 12061819 9020117 8885868 12648464 8657103 15951569 17016520 7693694
EGFR ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 20809984 17284441 16713569 11887937
EGFR VAV2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 17389395 19531499 11516622 26910843 10938113 10618391 12577067 12454019 17016520
EGFR CALM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 41.0 1.0 Omnipath 17145710 19901323 20029029 12359306 16497976 25402006 17389395 18578522 16799092 20068231 3415247 7925415 18669648 12153558 24658140 17287340 14960328 18707149 17016520
EGFR NCK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 1333047 23331499 31980649 10026169 16273093 9362449 8662998 24658140 25402006 15951569 9843575
EP300 PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12057991 17395887 17237818 12471036
AKT2 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17964260 16926151
AKT1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 17623675 18182168 16926151 20333651 19158375 17964260 17570479 11116148 25904863 21901101 23275565 16024795
IRF3 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9463386 9488451 11940575 9660935 21903422 10024886 11314014
EP300 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15965232
EP300 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 19608861 25400040 11567019 12419806 17617622 11533489 20333651 12456660 15152190 16846590 9096323 20064247 16382138 16713569 15171256 16135789
EP300 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11971970 10779504 24480624 17011549 16713569
EP300 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 9843571 19419955 22033265 9679056 21269274
MAPK14 NCOA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 22147914 16135815 20068231 19413330 16456540 16964243 18669648 15383283 15302935
MAPK14 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23216744 22431515 12138194 15879307
MAPK14 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 30644418 24424504 21820033 16282370
MAPK14 ARRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12738796 18039929 11274345 15187187
MAPK14 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12842894 15128824 15485852 10521409 15489227 15849198 15212693 12767944
MAPK14 EEA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16138080
MAPK14 SLC9A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 9776729 20068231 11604491 18701649 18669648
MAPK14 ELK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 52.0 1.0 Omnipath 9130707 20506250 8622669 23331499 21614932 16393692 20126313 17570479 18988627 23322625 10637505 15187187 26516701 15140942 11145955 11309409 8887554 9235954 8548291 15782123 20727996 8262053 19436832 12665513 12887893 11701445 12947314 15212693 11274345
MAPK14 NFATC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 15649893 20516082 16648474 15121840 12944472 10788511 11030334 10747897 17255949 11274345 12697810
CALM1 NFATC2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 8576111 8631904 10860980 9727000 8799126
PPP3CB NFATC2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 8576111 8631904 10860980 9727000 8799126
NFATC2 PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23105117 18006811 21871017
PRKCZ NFATC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17398070 12021260
PPP3CB NFATC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 9660947 11062529 12594826 18676376 8631904 11030334
PPP3CC NFATC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9660947 11062529 18676376 11030334
AR TNFRSF1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20610535
CASP7 TNFRSF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11755217 16189514
CD14 IRF3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 14517278 15210742 14703513 9566918 17823124 17157040
SMAD4 IRF3 â—¼   DOWN_REGULATES ✅ - 25.0 1.0 ACSN 10925299 11074002 11279127 11399519 11792802 11875494 12193690 12702545 12809600 15265520 15644117 16127449 16179589 16713975 17260466 17689680 18768831 21042762 21614932 22331441 23390297 6357187 8515656 8871614 9389648
IRF3 IFNA4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11846978 11884139 12242290 9786932 9707562 12821121 16380379 17785777 9446577 10692430
IRF3 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 59.0 1.0 Omnipath 10521456 17138826 19218087 10082512 15582653 21903422 17015689 23746807 23824799 16154084 15502848 25002588 9660935 14668346 17761676 12473110 20581830 9488451 25733689 18309294 9566918 10024886 17126870 16155125 15107417 17296604 11314014
CUL2 VHL â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
CUL2 VHL â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
DIAPH1 ACTB â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 12805219 18001770 12732141 12429848 18923426
RHOC ACTB â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 21576392 15507212 22275430 16439214 23222643 24914801 22094460
ACTB RHOA â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 12805219 18001770 12732141 12429848 18923426
PFN1 ACTB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 17541406 8413665 563468 10600384 10411937 10592173 19000816 16189514 19338310 9463375
AKT1 APPL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 25241761 10490823 25814554 12621049
CALM1 TRPC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 12601176 15104175 18215135 11290752 11248050
RHOC ACTG1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 21576392 15507212 22275430 16439214 23222643 24914801 22094460
RHOA ACTG1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 12805219 18001770 12732141 12429848 18923426
DIAPH1 ACTG1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 12805219 18001770 12732141 12429848 18923426
C3 CR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 10382758 2551147 9988761 2141838
FGF21 FGFR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16597617 25772309
ACTR3 ARPC2 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR3 ARPC2 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
PLCG1 FGFR3 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 19147536 16091734 10652257 10918587 19749790 18337450 16844695
NCK1 PLCG1 â—¼   ENZYMATIC_REACTION ✅ 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
FGFR3 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 17496910 12601080 17081983 16038803 1689310 1708307 7682059 15144186 8885868 16126727 15592455 8657103 16153436
ALK PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17145710 11888936 23331499 14968112 9174053
RHOA PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 12071848
TGFBR2 SMAD4 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11274345 14557817 15265520 16474430 17934056 20060931 20519943 21614932 22703233 24132110 24336330
SMAD4 ITGA11 â—¼   ENZYMATIC_REACTION ✅ 14.0 1.0 ACSN 11074002 11279127 11792802 12702545 12809600 15265520 16179589 16713975 21042762 21614932 22331441 23784029 9389648 9670020
SMAD4 ACTA2 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 8515656 9389648
TGFBR2 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8774881 20060931 11274345 21614932
SMAD4 FOS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 9732876 10942775
IL6 TGFBR2 â—¼   ENZYMATIC_REACTION ✅ 21.0 1.0 ACSN 11306493 15099563 15356132 15573129 18209571 18555777 18555778 19581928 20138012 23034983 23567181 24011634 24346288 25002027 25582338 26201938 26268945 27557510 7590867 8837607 9845545
IL6 IL6R â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
IL6 IL6R â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
CD14 IL6 â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
TIRAP IL6 â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
IL6 IL6R â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
FOS IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 10037779 10542237 9671466 2511437 25567680 20351184 24994901 11356008 11028561 12667961 18502099
RELA IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 114.0 1.0 Omnipath 26596471 19124729 10373597 9523851 23595969 28270510 21537341 17982049 15226358 18243142 12200447 20371366 24664372 23874122 14532843 18942706 10975857 21278793 10469356 22547075 17490702 11459775 23335080 10569191 19707556 19687301 7499267 8290595 23857586 24676671 18061164 11058167 12887736 15013753 15158360 22661093 20935672 20511231 17350185 10903137 16112536 27413250 21810609 16984731 16166627 18469854 12881425 24012417 23386688 22105366 8752656 12176740 27371733 22578249 18057724 20351184 10329846 19164127 10542237 11564778 20221401 15517885 19122653 20534538 7876168 27211851 9516466 18996370 8824277 18310089 21104991 25888873 12359431 11327783 20066113 20100571 19703987 19469019 21106671 16960103 18502099 16043358 21996739 20650996 22021035 11120852 12672795 12058956 18483242 22189669 14976218 17495236 11007957 21131967 11975924 27337441 9182853 10963848 17040605 11504280 15756023 10823821 17932106 19966855 20696864 12177065 8679226 9199307 17196927 20457835 21098092 17532054
AR IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12237244 8824277 19074897 11049111 17374439 11410519 20610535 19363165
IL6 IL6ST â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 17145710 14557255 19715447 3136546 12829785 18775332 7744001 8293462 15895091 11251120 2788034 1995637
IL6 IL6R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 55.0 1.0 Omnipath 17145710 8702737 7744001 23663276 15895091 9028955 1995637 23331499 12829785 3136546 21071413 14656210 28265003 12643274 7893704 18923185 11238858 8706672 8676083 18067990 2788034 14557255 18775332 9694899 7744875
RHOA PTEN â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10953004 11698448 11729192 11739775 11992112 12194823 12361600 12740575 12778124 14657501 14744429 15761148 15793569 17517963 18037882 18423981 20008297 20351293 20535745 21178402 21642958 21840487 22949611 24857661 24919149 26885855 27048821 27066895 7479854 9362522 9660866 9822605
PTEN AKT1 â—¼   DOWN_REGULATES ✅ - 22.0 1.0 ACSN 10753747 11747822 12040186 15721744 16288286 16982858 17218262 17409395 19440036 19847259 19945467 20609352 21084277 22179046 22465479 23732914 24030100 24254977 25364523 26597054 27328425 27572739
AKT1 PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 19903340 15987703 10790335 20596030 10592173 20605778 10866658 12077256 11035045 16107342 12297295
PTEN AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 15205473 24480624
PTEN IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16288286 10648629 17218262 12040186 15584861
ARHGAP35 RHOA â—¼   DOWN_REGULATES ✅ - 5.0 1.0 ACSN 17517963 18829532 22411312 8360177 9819392
RELA AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 24466341 16619263 14576180 15517885 14715080
RELA AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20186924 18031796 20649564
RELA EDN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21334436 10969841 18226221
RELA TRAF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 19343319 17673602 14991743 19383900 17018379 9733827 9733516 10823821 11297551
RELA BIRC2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15050749 17673602 12687011 12714587 15756023 12010810 18566231 16453001 20103608
RELA PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 43.0 1.0 Omnipath 16001969 9266823 19783677 12471036 17673602 10827178 16210649 20669087 12466023 15517885 15013753 12622742 20600530 14645117 18294142 19618291 12067569 15655349 17556653 18973191 14988266 12871860 20103608 19284764 15555528 21149600 11082190 15234907 9041934 22001128 16820889 18752821 19766095 15997464 8995303 9710122 12349897 15387324 15368354 18057724 15547942 16624933 17767925
PRKCZ RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 11684013 21515635 15210811 21131967 12881425 34230209 16189514 17183360 33864076 27466442
CREBBP RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 10542243 14597638 18241676 17138826 15140884 9096323 16713569 12456660 10454579 16382138 19608861 9806899 25314079 11931769 12163591 12881425 9659924 15171256 9548485 16291753 17362989 25733689 17434128 15334063 15806143 10235267 17296604
CD14 TIRAP â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16267105 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
CD14 TIRAP â—¼   SHARES_COMPLEX 26.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16267105 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
FGB TIRAP â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 21873236 11544529 22454496 16439361 15944945 12724322 17726518
NCOA3 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10777539 14966289 22977234 15798179 22608253 11747826
AR CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9822653 15350180 16492776 16344550 11161315 18819102 18031230 20610535
CREBBP ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9192902 18765668 16417649 11113179 8616895 11782371 14766010 17400812
CREBBP AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 20541699 9822653 15691881 12810069 9482849 16713569
IL13RA1 TIMP3 â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20856220 21115385 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 7543512 9834059
IL6R IL6ST â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 11238858 8706672 23331499 3136546 14656210 9694899 15895091 23663276 7744875 2788034
ARHGEF1 RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9789025 12748184 32203420 9113980 9641915 10836144 11149925
ARHGEF11 RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17145710 21988832 32203420 20300064 15530360 10526156
ARHGEF12 RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 9789025 17145710 15364580 23405219 32203420 9113980 9641915 20300064 10592173 11373293 12515866 11094164 11149925
ARHGAP1 RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 32203420 9535855 9548756 9407060 11927263 31467278 16189514 20660160 14749388
AKAP13 RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19696020 11696353 12423633 32203420
VAV2 RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9789025 32203420 9113980 9641915 10592173 11909943 11149925
RHOA DIAPH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 22820501 12773565 18218625 16109481 15864301
VEGFD FLT4 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 12881528 11532940 9435229 8617204 8700872
VEGFD FLT4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11279005 16336962 16633338 11532940 21148085 9435229
NCK1 DOCK1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15788770 11817894 18212043 18066058 12149262
KITLG TEC â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 16129412 7536744 12192036 10679268 7526158 9038210
ITGA11 IGF2 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 17420280 17600088 19913614 20129924 25076207 26148229
ITGA11 ACTA2 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 17420280 17600088 19913614 20129924 25076207 26148229
FOS PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15772294 11278336 9620167 17556653 12057991 8906578 17440114
IGF2 IGF1R â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 1310594 3019338 2839228 1845984 2969892 3011795 3013881 22140443 19139090 16981855
IGF2 IGF1R â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 11237532 15003992 17145802 17600088 24668028
ESR1 IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17170218 20021813 16087727 19250214 10982795 24281069 18414489 15595626
AR IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19318566 15033751 17202144 19250214 20610535
IGF2 IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 9972281 23331499 22810696 20980691 14604834 11867533
ESR1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11029009 15569929 18450422 20664923 15496458
AR AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 20589722 11278645 17896924 18687691 22740037 12621049 12063252 22970326
PRKCZ AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 11585925 15884057 14560023 16189514 11748077 18353613 11723139 10085094
AKT1 SLC9A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 20026127 16475831 18757828 10400637 33655882
AKT1 AKT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11546794 14500673 12176337 11445557 9736715 12149249 11278835
AKT1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 18521086 26944939 11108261 17627277 20101208 17570479 15604293 23169992 26554417 16452229 15193262 7838153 12374744 11139588 26272591 11432835 20179234 11507039 9528769
AKT1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 17470458 18349820 29861848 16210317 21601007 17570479 11404460 22155408 12621049 14555644 11156376
AKT1 RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11943559 23331499 25241761 21071413 12183455 15149849 11438723
ESR1 FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 8114761 9528985 18414489 10037443 21813366 11726205
RPS6KA1 FOS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 15187187 21233202 9920881 23331499 7601337 16286006 20068231 18452278 18988627 16393692 8248197 1545828 15239952 16055710
FGF9 FGFR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 23331499 16597617 25772309 8576175 10574949 8663044 15231666
CDK5 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 27917404 22014572 22275373 27902483 25982277 17043241 33932081 33038264 33974920 32846021 25851605 21799006 24424504 29423094 30414425 25691442 7565807 33994848
CDK5 STXBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12963086 15489225 16189514 9933594
PRKCZ AKT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 9512493 25241761 12162751 9305920
BIRC2 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 16339151 9384571 16189514 11084335
GNA13 ARHGEF12 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12515866 11094164 12024019
AKT3 CREB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 19216069 17680028 11756412 16680151 20214616 11463845 20452955 9829964 20398329 17646672 10217147
RPS6KB1 RPS6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 56.0 1.0 Omnipath 17053147 17081983 33676898 19339977 92042229 20484036 16286006 20647036 11438723 17360704 1737763 17121928 11108711 20227368 22408430 27312851 12668683 16083285 15051500 20146692 15471950 18423201 17570479 20039704 21460850 21602892 1985906 30034573 21233202 24662264 29892299 19720745 12586835 12713446 20464435 26824026 15809305 16810323 86287375 24396066 24578720 20616057 24205356 19203585 15905173 14993219 17726024 20832730 22530122 17052453 7705100 15358595
RPS6KA1 RPS6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 21233202 29892299 17081983 19369195 16083285 21418524 17360704 17664694 17287340 18187866 18669648 18974095
ESR2 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 14754635 24284820 15207704 18784357 11566442 12630920 22820289 19001520 18511514 14676837 19207817 22622808 21763263 18339713 15087130
ESR1 CAV2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12711000 12138116 18414489
ESR1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8299561 11000528 22391641
RPS6KB1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 29128895 23242584 22114931 23460185 19925796 19112174 7838153
RPS6KA1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 10949034 15528270 19925796 15461668 25336146 11139588 12118371 30034315 15059947 16076840 7491495 12093745 11432835 10411321 11507039 9528769 7838153
AR ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 12389206 11032808 16713569 11000528 18988627
AKT2 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 11139588 11432835 11507039 9528769 7838153
ESR1 ESR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 12630920 9473491 19746436 21182203 10706629 10022879
NCOA3 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 14966121 11747336 15563469 16713569 10965917 21047772
CASP7 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9535906 16713569
GNA13 ARHGEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 14607242 9641916 9641915 16189514 12681510
DLL3 NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 29910816 11823422 16921404 22353464
AGT AGTR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 12006574 21464395 10193788 10993080 16189514 15930094 9797979 16597412 17346243
RPS6KA1 VASP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 8182057 14679200 21423205 24097826 20463151 21451103 18637808
RPS6KA1 SLC9A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 27049728 23431433 10400637
ADM RAMP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11693189 30139742 15361343 15692146 12565884 9620797
ADM2 RAMP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 21658025 30139742 12684503
CAMK2G ADCY3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 9768837 8798667