CALM2
|
CALM3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
800.0
|
0.8
|
STRING
|
36370105
|
CALM1
|
CALM3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
800.0
|
0.8
|
STRING
|
36370105
|
CALM1
|
CALM2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
800.0
|
0.8
|
STRING
|
36370105
|
PRKACA
|
ACADVL
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19889959
|
BTRC
|
SKP1
|
â—¼ PROXIMITY
|
|
|
2.0
|
0.8
|
intact
|
29997244
20178071
|
EEF2K
|
CDK1
|
â—¼ PHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
6549277
18337751
|
MAPK14
|
DDB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
18806262
|
RPS6KB2
|
EEF2K
|
â—¼ PHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
11500364
5214384
|
EEF2K
|
RPS6KA1
|
â—¼ PHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
11500364
5214384
|
PRKACA
|
EZR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12840026
|
PRKACA
|
NFATC4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10611249
11749379
|
MAPK14
|
MAPKAPK2
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.8
|
0.8
|
Signor
|
14499342
|
EEF2
|
PA2G4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
804.0
|
0.8
|
STRING
|
36370105
|
CALM3
|
EEF2K
|
â—¼ PHYSICAL_INTERACTION
|
|
|
814.0
|
0.81
|
STRING
|
36370105
|
CALM2
|
EEF2K
|
â—¼ PHYSICAL_INTERACTION
|
|
|
814.0
|
0.81
|
STRING
|
36370105
|
CALM1
|
EEF2K
|
â—¼ PHYSICAL_INTERACTION
|
|
|
814.0
|
0.81
|
STRING
|
36370105
|
MAPK14
|
MAPKAPK2
|
â—¼ CORRELATES
|
|
+
|
0.82
|
0.82
|
CCLE
|
31978347
|
RAD18
|
ACACA
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.83
|
0.82
|
PKG
|
28854368
|
TULP3
|
RAD18
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
33961781
28514442
33187986
|
EEF2K
|
FBXW11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
854.0
|
0.85
|
STRING
|
36370105
|
TDP2
|
EEF2K
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.87
|
0.86
|
PKG
|
28854368
|
BTRC
|
FBXW11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
874.0
|
0.87
|
STRING
|
36370105
|
PPP1R8
|
PRKACA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
884.0
|
0.88
|
STRING
|
36370105
|
CALM3
|
EEF2K
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
3906654
3693353
11015200
|
CALM2
|
EEF2K
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
3906654
3693353
11015200
|
CALM1
|
EEF2K
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
3906654
3693353
11015200
|
MAPK14
|
PRKACA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
15649893
|
PRKACA
|
PRKAA2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
19942859
|
SKP1
|
FBXW11
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.93
|
0.93
|
mint
|
5212166
10644755
|
MAPK14
|
MAPKAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
943.0
|
0.94
|
STRING
|
36370105
|
SKP1
|
BTRC
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.96
|
0.96
|
mint
|
9660940
6547997
|
FBXW11
|
SKP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
969.0
|
0.96
|
STRING
|
36370105
|
SRP14
|
SRP9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
988.0
|
0.98
|
STRING
|
36370105
|
MAPK14
|
MAPKAPK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
991.0
|
0.99
|
STRING
|
36370105
|
BTRC
|
SKP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
999.0
|
0.99
|
STRING
|
36370105
|
HLCS
|
ACACA
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
7.0
|
1.0
|
Reactome
|
9630604
14766011
10677481
7732023
16134170
20153287
22123817
|
PRKACA
|
ACACA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
7907095
2900138
|
PRKAA1
|
ACACA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
32.0
|
1.0
|
Omnipath
|
19651622
11052978
20166139
9029219
18669648
18767875
2900138
12015362
20068231
18707149
7907095
7915280
16326698
18212344
|
PRKAA2
|
ACACA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
35.0
|
1.0
|
Omnipath
|
19651622
11052978
20166139
9029219
18669648
18767875
2900138
12015362
20068231
18707149
19061860
17519230
7907095
7915280
29899443
16326698
18212344
|
CDK1
|
BAD
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
9.0
|
1.0
|
ACSN
|
12049737
14551205
15279786
17303408
17660363
18414028
18590585
21725609
7575488
|
RPS6KA2
|
BAD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
55.0
|
1.0
|
Omnipath
|
11983683
10880354
20166139
9346240
11493700
9381178
15037618
15280015
10230394
10558990
8929531
19641507
18669648
10837486
10611223
15226424
12954615
10521512
10949026
15972258
18707149
12897128
19282669
16403219
17270021
|
RPS6KA1
|
BAD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
62.0
|
1.0
|
Omnipath
|
11983683
10880354
20166139
9346240
11493700
9381178
15037618
11152955
15280015
10230394
10558990
8929531
10976111
18669648
10837486
10611223
15226424
22558198
12954615
18246127
10521512
10949026
15972258
10679322
18039929
18707149
12897128
16403219
17270021
|
RPS6KB1
|
BAD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
14.0
|
1.0
|
Omnipath
|
15280015
10611223
12954615
9346240
11493700
10230394
10558990
8929531
9381178
19641507
17270021
10837486
|
CDK1
|
BAD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
17.0
|
1.0
|
Omnipath
|
18071308
16166315
24677263
12965220
15907327
26287183
21858202
25618528
12049737
16009721
19124971
16403219
17498878
|
PRKACA
|
BAD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
49.0
|
1.0
|
Omnipath
|
11983683
10880354
20166139
9346240
11493700
9381178
18794113
12931191
15280015
10230394
10558990
8929531
18669648
10837473
10837486
10611223
12954615
10949026
10851172
15123689
18707149
16403219
17270021
|
CDK1
|
EEF2K
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
12.0
|
1.0
|
Omnipath
|
18337751
14709557
20012461
12171600
11500363
|
CDK1
|
RPS6KB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
40.0
|
1.0
|
Omnipath
|
17081983
15208671
15070696
15798205
17570479
18669648
15774499
12935893
12586835
12555062
15809305
12740386
11279232
9271440
15235105
12036952
11914378
11872747
14993219
11705993
16964243
|
EEF2K
|
EEF2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
65.0
|
1.0
|
Omnipath
|
22669845
17081983
18614030
20166139
18767875
21307130
23184662
91085562
21112387
28060762
12194824
19413330
24958351
16858730
3906654
25686034
18188169
16083285
24574971
20068231
30214154
24955726
2261989
11500363
25623400
18669648
8386634
2704236
22352903
20837011
9133370
17287340
2458772
29610153
21203441
19651622
11500364
30218597
12171600
15024086
3693353
18212344
19152646
|
RPS6KA1
|
EEF2K
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
22.0
|
1.0
|
Omnipath
|
11171059
11500364
14709557
20837011
15024086
|
MAPK13
|
EEF2K
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
16.0
|
1.0
|
Omnipath
|
18337751
11500363
14709557
12171600
|
MAPK14
|
EEF2K
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
14709557
17570479
12171600
|
RPS6KB1
|
EEF2K
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
22.0
|
1.0
|
Omnipath
|
11171059
11500364
14709557
23102376
15024086
21203441
|
PRKACA
|
EEF2K
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
18.0
|
1.0
|
Omnipath
|
11500364
11171059
14709557
15024086
|
PRKAA2
|
EEF2K
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
19.0
|
1.0
|
Omnipath
|
11500364
11171059
14709557
15024086
|
RPS6KA2
|
EEF2K
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
11500364
11171059
14709557
15024086
|
PRKAA1
|
EEF2K
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
21.0
|
1.0
|
Omnipath
|
11171059
22669845
11500364
14709557
15024086
|
FBXW11
|
SKP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
23.0
|
1.0
|
Omnipath
|
17145710
25609649
10321728
25900982
15070733
12165731
10230406
21145461
26496610
24500709
10023660
10066435
25332235
19615732
19159283
27705803
10644755
25515538
|
MAPK12
|
MAPKAPK5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
15187187
18039929
9628874
12738796
11274345
|
MAPK12
|
MAPKAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
12738796
18039929
11274345
15187187
|
MAPK12
|
MAPKAPK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
12738796
18039929
11274345
15187187
|
MAPK13
|
MAPKAPK5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
15187187
18039929
9628874
12738796
11274345
|
MAPK13
|
MAPKAPK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
12738796
18039929
11274345
15187187
|
MAPK13
|
MAPKAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
15187187
9207191
18039929
12738796
16189514
11274345
|
MAPK14
|
MAPKAPK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
63.0
|
1.0
|
Omnipath
|
21675959
16456544
23602568
17395714
21988832
10581204
23331499
21071413
27898710
23047924
10922375
12738796
11551945
26496610
25852190
18988627
15629715
18669648
15187187
11042204
26186194
25241761
8846784
17906627
14499342
9922370
7923353
9768359
18039929
25255283
7592979
17255097
11274345
23455922
|
MAPK14
|
MAPKAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
24.0
|
1.0
|
Omnipath
|
23602568
10581204
23331499
21071413
12738796
26496610
16189514
25852190
15187187
8626550
26186194
25241761
17906627
9922370
18039929
11157753
31515488
11274345
23455922
|
MAPK14
|
MAPKAPK5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
21.0
|
1.0
|
Omnipath
|
15187187
20936779
18039929
9628874
23331499
12738796
11274345
11157753
18988627
18669648
|
MAPK14
|
NFATC4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
16.0
|
1.0
|
Omnipath
|
15649893
16648474
11997522
10747897
18347059
17255949
11274345
12697810
|
PRKACA
|
MAPKAPK5
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
17947239
20734105
20849292
19166925
|
RPS6KA2
|
NFATC4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
15187187
21233202
16286006
15657420
15239952
|
PRKACA
|
PPP1R8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
10.0
|
1.0
|
Omnipath
|
9407077
18669648
20068231
|
PRKACA
|
PRKAA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
12764152
17023420
27784766
|
DDB2
|
EEF2K
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.36
|
1.35
|
PKG
|
28854368
|
SETX
|
EEF2K
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.39
|
1.38
|
PKG
|
28854368
|
TDP2
|
TDP2
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-2.0
|
1.99
|
PKG
|
28854368
|
RAD18
|
EEF2K
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-2.06
|
2.05
|
PKG
|
28854368
|
RAD18
|
RAD18
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-4.39
|
4.38
|
PKG
|
28854368
|
DDB2
|
DDB2
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-5.71
|
5.7
|
PKG
|
28854368
|
SETX
|
SETX
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-8.56
|
8.55
|
PKG
|
28854368
|