Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
GRB2 ACKR3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
TP53 APC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18431400
TP53 ATF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11350971 10984493
ATF2 RHOB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11160903 21565167
SP1 BBC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18811981
RUNX2 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17517365 23073173
HSP90AA1 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18266962
NFKB1 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11704864 11313951
TP53 FANCC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9063748
TP53 FANCC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
HSP90AA1 FANCC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18266962
TP53 GDF15 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17276395
SP1 GDF15 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11895857
JAK2 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9209406 8400282
CNTFR GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
DLG4 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
SP1 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
SF3B4 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
TNFRSF14 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GRB2 ACTG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 GSTM3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 AIRE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GRB2 RUVBL1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 LEPR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GRB2 HSP90AB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 TNFRSF14 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12796776 16932752
HSP90AA1 TAB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AA1 TAB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AA1 AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12799359 11988487
HSP90AA1 ZAP70 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16888650 5218924
TAB1 MAPK14 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5215125 11847341
MAPK14 RUNX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 29057206 20551513
RHOA OTUB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20553488 7717051
OTUB1 SMAD9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
JAK2 PRKCD â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
IFNGR1 PRKCD â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
RUVBL1 TAB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
RUVBL1 TAB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
SKIL IL36RN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SKIL SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12419246 12426322
BMX TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217965 16186805
TP53 PRKAA2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15866171 24874608
TP53 PRKAA1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15866171 24874608
TP53 CTSL â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17916908 20536385
TP53 MAP2K1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10529175 9724739
TP53 ROCK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21221513 17344417
IKBKB TP53 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 19196987 0812256106
TP53 GSK3B â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5216887 14744935
TP53 FASLG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10969818
TP53 TNFRSF10A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11382926
TP53 BIRC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16917513
TP53 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
SP1 CD83 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12182451
NFKB1 CD83 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19164127 12182451
RUNX2 AXIN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19585539 23300083
SF3B4 MAPK9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
SMAD1 BMP7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20375015 17127702
CAV1 ACTB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17502619 0611416104
SMAD9 ACTB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
ACTG1 IKBKB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
ACTG1 TAB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
SMAD1 HAND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22219353
SMAD5 HAND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22219353
BMP10 ACVRL1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17068149 17311849
MEF2C BMP10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22996691 15073151
ID1 ID3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21156287 22564737
SP1 AREG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14742435
NFKB1 FBP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11023824
ITGAV TGFBR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PDGFRB IL1R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0510973103 16477012
PDGFRB JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8657151 9484840
TGFBR2 USP15 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22344298 16027725
TGFBR2 BAMBI â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10519551 19758997
FKBP1A TGFBR2 â—¼   DOWN_REGULATES ✅ - 2.0 0.8 ACSN 11226255 14766396
SMURF2 TGFBR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22298955 15221015
TGFBR2 MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16360132
MAP3K7 IKBKB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219785 17363973
BMPR1B SMAD7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12857866 12519765
SMURF2 SMAD7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD7 ACVR2B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12857866 12519765
SMAD7 BAMBI â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10519551 19758997
SMAD7 ACVR2A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12857866 12519765
SMAD7 BMPR1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12857866 12519765
SMAD7 BMP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12857866 12519765
SMAD7 BMPR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12857866 12519765
SMAD7 TGFB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10519551 19758997
AXIN1 SMAD7 â—¼   COLOCALIZATION 2.0 0.8 intact 16601693 5218493
SMAD7 ACVR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10564272 23331499
SMAD7 ACVRL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 12023024
SMAD7 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10564272 23331499
JAK2 CNTFR â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12707266 7852997
JAK2 EBI3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22306691 12829785
TGFB1 BAMBI â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10519551 19758997
TGFB1 USP15 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22344298 16027725
RASA1 HRAS â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5221569 9219684
HRAS CAV1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8621645 5220985
RASA1 CAV1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6731661 15504032
GSK3B AXIN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219694 17318191
WNT3A AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10428961 8666229
FZD5 AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10428961 8666229
SMURF1 SMAD5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
RUNX2 SMURF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24631292 23042144
SMURF1 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22298955 17317136
SMURF1 BMPR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22298955 17317136
SP1 HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12847090 5216518
NFKB1 HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11931769 5215238
SP1 BIRC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19120021
SP1 CCR7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22718198 23649655
RHOA GATA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22758628 12878473
RHOA AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15884057 11748077
HSP90AB1 TAB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
SMURF2 SMAD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMURF2 SMAD5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SP1 MAP2K1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17889508 16452190
SP1 BMP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21411747 17350185
SP1 BMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12220517 19009553
SP1 PAX6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11574690
IGF1R YWHAG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
VHL IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17486080 19509240
IGFBP3 YWHAG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NFKB1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18031796
GATA4 MEF2C â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15843409 15253934
MEF2C SOST â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17696759
MEF2C RUNX2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath
NFKB1 BMP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17350185
NFKB1 AMH â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15383177
NFKB1 TLR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19779021 12686724
NFKB1 TNFRSF10A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21243522
NFKB1 BIRC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9294162 9733516
AKT3 BMI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22505453
BIRC3 BIRC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23070005 18485876
HSP90AB1 IKBKB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
YWHAG ARHGEF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
ARHGEF2 RHOB â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 16917499 18287519
SMAD9 SMAD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8893010 11779505
SMAD1 SMAD5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD1 RUNX2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19664780 24692107
ACVRL1 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9748228 23331499
SMAD1 RUNX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17215250 22298955
ACVR2B ACVRL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16446785
BAMBI ACVRL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10519551 23331499
GSK3B APC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 10698523
ACVR2B ACVR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16446785
BMP8B ACVR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 10504300
ACVR2A ACVR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9748228 8612709
BMPR1B ACVR2B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7644468 7791754
BMPR1B ACVR2A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7644468 7791754
BMPR1A BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10712517
ACVR2B BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16446785
BAMBI BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10519551 23331499
BMPR1B SMAD9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19620713 11792802
SMAD6 ACVR2A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12857866 12519765
ID1 BMP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20970407 21996749
LITAF SMAD5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SMAD9 SMAD5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8893010 11779505
SMAD6 BMP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12857866 12519765
GATA4 BMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23632743 24866243
SMAD6 ACVR2B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12857866 12519765
BMPR1A ACVR2B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7644468 7791754
ACVR2B ACVR1C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16446785
SMAD6 BMPR1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12857866 12519765
BMP8B BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 10504300
BAMBI BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10519551 23331499
SMAD6 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10564272 23331499
NOG BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22298955 12478285
BMPR1A SMAD9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19620713 11792802
SMAD6 BMPR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12857866 12519765
NOG BMPR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22298955 12478285
BMP6 AMHR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16446785
GATA4 NKX2-5 â—¼   PHYSICAL_INTERACTION 801.0 0.8 STRING 36370105
ACVR1 BMP7 â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
BMPR1B FKBP1A â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
ACVR1 FKBP1B â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
MAPK14 TAB1 â—¼   PHOSPHORYLATION ✅ - 0.8 0.8 Signor 19393267
SMAD6 SMURF1 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
HSP90AA1 MAP3K5 â—¼   PHYSICAL_INTERACTION 807.0 0.8 STRING 36370105
HSP90AB1 MAP3K5 â—¼   PHYSICAL_INTERACTION 807.0 0.8 STRING 36370105
GRB2 HCLS1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 9670936
CAV1 RHOA â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 31871319 20460433 9647788
GSK3B SMAD1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 25241761 18045539
ACVR1 BMPR2 â—¼   PHYSICAL_INTERACTION 814.0 0.81 STRING 36370105
BIRC3 OTUB1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23524849 30948266
CD83 BMPR2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
AXIN1 AXIN2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22682247 20128690
MRAP2 ACVR1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
MRAP2 BMPR2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
AREG SNX11 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
TAB1 MAP3K7 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 5218828 16845370
RHOB CAV1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
AKT3 AKT1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
RHOB DLG1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
AKT1 HSP90AB1 â—¼   PHYSICAL_INTERACTION 820.0 0.82 STRING 36370105
ACVRL1 BMP10 â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
GRB2 PDGFRB â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
AKT1 GSK3B â—¼   DOWN_REGULATES ✅ - 0.82 0.82 Signor 15829723
AKT1 GSK3B â—¼   PHOSPHORYLATION ✅ - 0.82 0.82 Signor 23552696
GRB2 ZAP70 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 23267066 7629168
ACTB CAV1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 17502619 28734243
CAV1 BMX â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16189514 11751885
SMAD7 TAB1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 12589052 11737269
CCR5 JAK2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 11278738 11591716
ZAP70 RASA1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 7760813 16189514
AXIN1 DVL3 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 22682247 12805222 20128690
RHOC RHOA â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 31871319 33961781 31980649
WWP2 AMOT â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 31048545 33961781 26186194 25071155
BMPR2 BMP6 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 11401330 10504300
AKT1 MAPK14 â—¼   PHYSICAL_INTERACTION 830.0 0.83 STRING 36370105
AXIN1 DVL3 â—¼   PHYSICAL_INTERACTION 834.0 0.83 STRING 36370105
SMURF1 SMAD6 â—¼   RELOCALIZATION ✅ - 0.83 0.83 Signor 22298955
RASA1 GRB2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 16189514 12441060 16713569
RUNX2 SMAD1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10531362 10962029 17215250 20851880
SMAD5 ACVR1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10652350 16189514 10583507 9748228
AXIN2 APC â—¼   PHYSICAL_INTERACTION ✅ + 0.84 0.84 Signor 10911903
SMAD7 WWP2 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
IKBKB NFKB1 â—¼   PHOSPHORYLATION ✅ - 0.84 0.84 Signor 11158290
AXIN1 APC â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 7025676 19131971
RHOB ROCK1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 34079125 31871319 34187934
AKT2 AKT1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 28514442 12149249 9736715 12176337 11445557 33961781 14500673 11278835 11546794
ACVR1 FKBP1A â—¼   PHYSICAL_INTERACTION 850.0 0.85 STRING 36370105
RUNX2 SMAD1 â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
SMAD1 SMAD6 â—¼   PHYSICAL_INTERACTION 855.0 0.85 STRING 36370105
BMP7 ACVR1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 8006002 18070108 16189514
SMAD7 AXIN1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16601693 18593713
SMAD5 RUNX2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 10531362 22966907
ARRDC3 PRKAA2 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HuRI 32296183
ACVR2B BMPR1A â—¼   PHYSICAL_INTERACTION 864.0 0.86 STRING 36370105
GSK3B TP53 â—¼   PHYSICAL_INTERACTION 866.0 0.86 STRING 36370105
SMAD7 SMAD6 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 26555259 9256479
HDAC1 VHL â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 22286234 11641274
HDAC1 REST â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 18806873 10491605
ACTG1 RUVBL1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
ACVR2B BMP2 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
BBC3 BCL2 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
BIRC2 TNF â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
SMURF2 SMAD7 â—¼   UBIQUITINATION ✅ - 0.87 0.87 Signor 18448069
SMAD7 SMURF2 â—¼   RELOCALIZATION ✅ + 0.87 0.87 Signor 19352540
RHOA SMURF1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
APC DLG1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 30126976 23185543
GRB2 SF3B4 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 17474147 21988832
MAPK14 TP53 â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
AXIN2 GSK3B â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 12183362 10966653 33961781 23602568 32707033 23455922 29568061 30824926
BMPR2 BMP7 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 7644468 7791754
SMURF1 SMURF2 â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
SP1 NFKB1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 18083845 16740634 33572115 7933095
ACVR1 SMAD1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16189514 10583507 10652350 9748228 28847510 10085121 9136927
BMP4 BMPR2 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
PDGFRB RASA1 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
BMP2 BMPR1B â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
BCL2 TP53 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
CSF1R GRB2 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
HSP90AA1 HSP90AB1 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
TGFBR2 TGFB1 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 8044119 21054789
SMAD6 SMAD1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11483516 12857866 9436979 9256479
BMPR2 ACVR1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 7890683 28514442 7791754
ACVR2A INHBA â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
BMPR2 BMP4 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28126904 12045205 7673243 7644468 8702914
INHBA FST â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 7887917 16198295
RGMB BMP2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 25938661 15671031
HDAC1 NFKB1 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
SMURF1 SMAD7 â—¼   UBIQUITINATION ✅ - 0.89 0.89 Signor 12519765
SMAD7 SMURF1 â—¼   RELOCALIZATION ✅ + 0.89 0.89 Signor 19352540
JAK2 LEPR â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
SMAD5 SMURF1 â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
SMAD1 SMURF2 â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
ACVR2A BMPR1A â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
IL1RN IL1R1 â—¼   PHYSICAL_INTERACTION ✅ - 0.89 0.89 Signor 2876877
IKBKB MAP3K7 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
TAB1 TAB2 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
ATF2 MAPK9 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
AXIN1 APC â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16199882 22682247 10228155 29045831 18786926 20128690 19131971 26496610 10811618 9734785 29713058 23277359 17510365
AXIN2 APC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10966653 10911903 9554852
SP1 ATF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 2145272 12760745
ATF2 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17258390 22542937 15546613
JAK2 GRB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 7500025 17474147 8536716 8950973
RASA1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12441060 16713569
HRAS HSP90AA1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16024644 15118125 15284455
HSP90AA1 BIRC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 14614132 15894266 15218035
TP53 MAPK14 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11437382 15132979 14570892
TSC22D1 OTUB1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
SKIL SMAD7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 23154975 16442497
TP53BP2 TP53 â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 21513714 8152471
TP53 TNFRSF10C â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14623878 11495702
TP53 TNFRSF10A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15289308 11313989
SP1 CXCL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11115149 7479086 11112786
PRKAA2 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21673972
SMAD1 ID3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18372118 21056086
SMAD5 ID3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18372118 21056086
CAV1 PDGFRB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10066366 11168929 23331499
TGFBR2 SMURF2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15496141 11163210 11278251
TGFBR2 SMURF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15496141 11163210 11278251
TAB1 TAB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 14670075 14743216 10882101 17626013 21988832 18021073 19393267 27880917 19675569 12242293 16845370 32410369 33961781 25260751 21903422
WWP2 SMAD7 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 22773947 31546607 21258410
SP1 SMAD7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16714330 10843994
AXIN1 SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16601693
SMAD7 BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10564272 23331499 15761153
SP1 IFNGR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11477089 17339358
JAK2 CSF2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 2681215 1400495 1396555
IL31RA JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 18926762
TGFB1 SMURF2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15496141 11163210 11278251
TGFB1 SMURF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15496141 11163210 11278251
FKBP1A TGFB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11960000 23734213
AXIN1 GSK3B â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25241761 17601533 21988832 10228155 24976009 30181396 20128690 12511557 17318191 16293724 23455922 28546513 17318175 19303846 18632848 19131971 16890161 26496610 23892894 23602568 22613765 18593713 29568061 21242974 22682247 19759537 11738041 22270359 24451375 9734785 32707033 21502811 17510365 10481074 16199882 26912724 23959799 29045831 22509369 29789528 19202075 12584189
APC2 AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 9601641 10980707
ACVR2A SMURF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12151385 12857866 11278251
BMP2 SMURF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12151385 12857866 11278251
ACVR2B SMURF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12151385 12857866 11278251
SMURF1 SMAD6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11278251 22298955 29950561
HDAC1 SP1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15647279 20072153 19062177 11909966 17894944 21636851 18003922 12176973 11896613 15557281 10409740 11517158 15713621 12665570 15722551 17906119 16478997 18850004 16121030 16883603 12091390 15155736 18948152 18059533 16713569 20385359 15528196 16734381 12200149 12847090
NFKB1 CCR7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19164127 11830455 22158872
SP1 CSF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7811231 8524292 11418664
RHOA DLG4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9870943 9870942 16202622
ACVR2A SMURF2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12151385 12857866 11278251
BMP2 SMURF2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12151385 12857866 11278251
BMPR1B SMURF2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12151385 12857866 11278251
BMPR2 SMURF2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12151385 12857866 11278251
ACVR2B SMURF2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12151385 12857866 11278251
BMPR1A SMURF2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12151385 12857866 11278251
SP1 NFKB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20427719 20538607 9151857
AKT1 GSK3B â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19713527 8524413 23824745 16009706 29464284 20856200 19995607 16123141 20682768 27563096 14645548 15688030 22337773 11035810 17428466 18505846 15470047 14701753 16282323
NFKB1 BIRC2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 21725609 23178297 23572150
NFKB1 IL1RN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20032313 12423202
NFKB1 IL17C â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21628458
AKT2 BMI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23092893 22505453
SMAD1 TNFRSF11B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11139569 14672939
RHOB DLG4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9870943 9870942 16202622
RHOC DLG4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9870943 9870942 16202622
GSK3B FZD5 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
AMHR2 ACVR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 14746809 16446785
SMAD6 ACVR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23455153 23331499 10564272
ACVR1 SMAD9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10583507 16189514 11792802
SMAD6 BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10564272 23331499 15761153
ACVR2A ACVR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12682303 9032295 8612709
NOG BMP4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10657699 12700180 11706034
BMPR2 BMP2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10880444 10712517 25938661 7791754
ACVR2B BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 17295905 16446785
BMPR1A FAM83G â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24554596
HSP90AA1 TP53 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
ACTB ACTG1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HuRI 32296183
GDF2 ACVRL1 â—¼   PHYSICAL_INTERACTION ✅ + 0.91 0.91 Signor 17068149
APC GSK3B â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
FBP1 FBP2 â—¼   PHYSICAL_INTERACTION 0.91 0.91 HuRI 32296183
BMP4 BMPR1A â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
AXIN2 GSK3B â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
HDAC1 SP1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
HDAC1 TP53 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
BMP7 NOG â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
IL1R1 IL1RN â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
AKT1 GSK3B â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
ACTB RUVBL1 â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
RHOA ROCK1 â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
AKT3 MAP3K5 â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
ACVR2A BMP7 â—¼   PHYSICAL_INTERACTION 940.0 0.94 STRING 36370105
ACVRL1 GDF2 â—¼   PHYSICAL_INTERACTION 940.0 0.94 STRING 36370105
FST INHBA â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
ATF2 MAPK14 â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
AKT1 HSP90AA1 â—¼   PHYSICAL_INTERACTION 946.0 0.94 STRING 36370105
SP1 TP53 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
ACTG1 ACTB â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 8153045 21516116
AKT1 MAP3K5 â—¼   PHYSICAL_INTERACTION 953.0 0.95 STRING 36370105
ACVR2B INHBA â—¼   PHYSICAL_INTERACTION 953.0 0.95 STRING 36370105
ACVR2A BMP2 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
CSF1R GRB2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 10025673 8262059 7597091 9380408 9178909
HDAC1 RBL1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 10490602 9724731 16189514
ITGAV TGFB1 â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
IKBKB NFKB1 â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
MAPK14 TAB1 â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
APC GSK3B â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 11166179 29045831 21118991 8638126 11251183 23602568 29568061
HDAC1 NFKB1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 25241761 12972430 17962807 24448807 11931769 14678988 16319923 17827154
ROCK1 RHOA â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 21281639 31431478 8816443 14660612 12773565 8798490 31871319
BMPR1A BMP2 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 19804412 7261592
SMAD7 SMURF2 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
BMP2 RGMB â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
HRAS RASA1 â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
TP53 TP53BP2 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
SMAD7 SMURF1 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
SMAD1 SMURF1 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
BMP2 BMPR1A â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
BBC3 BCL2 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 15694340 16697956 14681455 17289999 33961781 11463392 26431330
MAP3K7 TAB2 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
AXIN1 GSK3B â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
APC AXIN1 â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 10421629 10581160 11487578 11955436 11967263 12051714 12554650 15001769 15327768 16039586 16288291 16940750 17143292 17318175 17936032 19619488 19751508 20006983 20705860 22270359 23343194 24023259 25730849 7542250 8638126 8666229
APC USP15 â—¼   PHYSICAL_INTERACTION 61.0 1.0 ACSN 10023660 10671552 11348595 11900249 11955436 11967263 12051714 12648680 12820959 15001769 15071497 15340381 15459660 15688063 15703371 16039586 16697054 16713974 16940750 17143292 17652783 17884153 17928543 17936032 18196958 18805092 18931676 19250909 19258535 19270156 19352404 19366350 19411070 19576224 19597341 19619488 19622404 19686080 19751508 19809470 19836308 19847258 19849719 20006983 20558317 20705860 20843316 20976471 21411632 22270359 22682247 22730322 23343194 23732914 24023259 25730849 26885856 7542250 7641885 8666229 9694792
APC AXIN1 â—¼   PROTEIN_INTERACTION 26.0 1.0 ACSN 10421629 10581160 11487578 11955436 11967263 12051714 12554650 15001769 15327768 16039586 16288291 16940750 17143292 17318175 17936032 19619488 19751508 20006983 20705860 22270359 23343194 24023259 25730849 7542250 8638126 8666229
APC USP15 â—¼   SHARES_COMPLEX 61.0 1.0 ACSN 10023660 10671552 11348595 11900249 11955436 11967263 12051714 12648680 12820959 15001769 15071497 15340381 15459660 15688063 15703371 16039586 16697054 16713974 16940750 17143292 17652783 17884153 17928543 17936032 18196958 18805092 18931676 19250909 19258535 19270156 19352404 19366350 19411070 19576224 19597341 19619488 19622404 19686080 19751508 19809470 19836308 19847258 19849719 20006983 20558317 20705860 20843316 20976471 21411632 22270359 22682247 22730322 23343194 23732914 24023259 25730849 26885856 7542250 7641885 8666229 9694792
GSK3B APC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 16944320 11166179 16799642 11967263 14663202 8524413 12554650 8638126 17910481 15327768 10581160 11487578 17318175 15465828 10228155 15020233 10421629 10698523 9832503
AXIN1 APC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 16199882 20128690 19131971 11297546 9554852 22682247 10228155 26496610 23277359 10811618 9734785
ATF2 GRB2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 11274345 12738796 18039929 20506250
ATF2 TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 20068037 15356147 11490006 10748079 12509451 10688670 10318823 10913190 10954918 16888805 15546613 20018859 9826775 8816436 8552071
MAPK9 ATF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 55.0 1.0 Omnipath 17145710 17081983 18767875 20506250 25416956 19255142 19413330 20028971 8654373 12788955 11994493 11566021 10777545 7535770 8709204 17875713 20068231 16393692 15192015 7737130 18669648 10066798 602896 11896587 12110590 32296183 11971971 19651622 19436832 16533805 11865055 19822663 11823524 31515488 7737129 11274345
MAPK14 ATF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 104.0 1.0 Omnipath 17081983 18767875 21098032 20506250 26359454 19690332 11060298 19413330 12788955 10085140 22037767 11566021 17079470 19647037 10581204 10777545 7535770 23331499 7839144 19324872 21071413 21614932 20068231 16393692 15304344 17570479 17380123 18988627 7737130 18669648 15187187 9305639 7737129 15140942 602896 11896587 17548358 12110590 7824938 8663524 33893075 12024021 11078583 11971971 9707433 17258390 10821277 19651622 19436832 11259586 27726305 11781825 9430721 27142525 10909971 12118074 15569672 15212693 9753474 11274345 10903740 26987986
BCL2 BBC3 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 11463391 11463392 11704864 17446862 22039431 23064052 23377657 23430059 23850759 8929532
BCL2 BBC3 â—¼   PROTEIN_INTERACTION 10.0 1.0 ACSN 11463391 11463392 11704864 17446862 22039431 23064052 23377657 23430059 23850759 8929532
TP53 BBC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 23916609 14665630 18397889 17390010 22763818 11463391 15988033 16462759 17280505 22948151 16151013 20190809 23678107 17989286 17360476 11756653 20331637 21835778 15790310 17440969 20478995 17047080 12384701 18657356 18755897 15489892 18579560 11463392 11572983 15007388 17610896
TP53 BBC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12574499 11463391 11463392 14634023 14684737
BBC3 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17145710 16697956 15694340 11463392
NFKB1 BCL2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 11313951 11704864 21725609 23178297 23572150
BCL2 GRB2 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 11463391 11463392 11532940 11704864 12566895 12667443 14764585 15516985 17446862 19289794 19565474 22039431 23064052 23377657 23430059 23850759 24027568 8929532 9069260 9872359
GATA4 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18653721 17098826 19602725 16469847
NFKB1 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 16254192 11567031 17673602 18031796 12835724 15120608 20332461 14978135 20446017 18566231 19259124 14739605 21503108 20103608 17098279 18158998 12032828 19233129 16022909 18761399 18987666 15934930 21224428 16453001
SP1 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 14660675 20435036 12032828 10542244 15713621
TP53 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 41.0 1.0 Omnipath 17693666 8183578 10037739 16738310 18397889 19521340 18487508 21666495 16294215 21656028 22869582 19714248 10744634 8174112 17592775 11782367 19137013 20428827 18682598 11713302 11313951 20501806 9649502 24814047 15767042 24098340 11193470 10329733 21859835 22266868 10953306 19555669 23638218 14684736 19411072 20530667 24155778 8205530 20840522 9000137 15326476
TP53 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 12667443 19555669 8205530 19007744 11313951
AKT1 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 21303971 11882383 17680028 20214616 22094462 20398329 21506126 20028971 12040186 18218901
MAPK14 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 29050237 16714293 19336399 11495898
AKT3 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 21303971 11882383 17680028 20214616 22094462 20398329 21506126 20028971 12040186 18218901
TP53 GDF15 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 17762884 12011055 10618379 17191121 11895857 21586550 10777512 12767058 20230799 17276395 16435911 11994274 17569660
HRAS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
ZAP70 GRB2 â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 10562324 10925299 11353765 11438547 11875494 12415267 12731048 12811837 15735648 16713974 17371980 20435894 20814939 21059766 23414611 23508573 23620508 23886063 24378531 7600293 8478617 8642247 9625766 9738502
PDGFRB GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 7935391 16713569 7486683
CSF1R GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9178909 9380408 10025673 8262059
JAK2 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8536716 8950973 7500025 17474147 19273609
GRB2 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17496910 16713569 17673906 11352655
NFKB1 HSP90AA1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 17724475 21725609 23178297 23572150
TP53 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15358769 15284248 24451373 18996350
HSP90AA1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 12427754 10557093 21460846 16713569 11507088
HSP90AA1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 19356729 18266962 10995457 25714412 16189514 12176997 12586360 15843522
MAP3K5 MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 10644746 12775720 23857585 8622669 15632108 21177868 17392283 16648474 27577261 33685990 17438131 20570725 17442957 20068182 15817653 15917303 21835346 20799279 16709866 12101183
MAP3K7 MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12589052 17965022 15692051 17947236
ZAP70 MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23109003 26390817 15735649 15735648
MAPK14 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 26822034 17726008 21303975 18451303
MAPK14 TAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 28.0 1.0 Omnipath 24443058 22216226 33204339 19393267 25241761 11847341 16648477 12429732 14592977 22307082 17570479 26391660 17126905 21900206
MAPK14 MAP2K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15187187 18039929 12738796 11274345 12697810
MAPK14 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 57.0 1.0 Omnipath 21675959 26247731 20213747 17535811 20506250 15657900 9315650 15642743 19413330 11283254 22975381 10581258 16083285 1088347 21614932 16393692 10884347 21050851 16552184 10747897 15187187 17906639 25789565 15140942 11258706 24818748 19436832 10781582 10212189 17172861 10348343 11078726 11274345
MAPK14 MEF2C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 21902831 9069290 23331499 9858528 9384584 10330143 9753748 10805738 16189514 18988627 26660426
PRKCD TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17906639 16314418 16377624
PRKCD IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 17496910 11940581 21386996 11884618 11447289 19615955 16488589 6321473 8321321 12845332 11313945 12040186 19568798 15567848 14585353
SMURF2 SKIL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11389444 23331499 15221015
TNF CXCL1 â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10925299 11112697 11438547 11875494 12646658 12811837 1431106 14607933 14625680 15099563 15699106 16713974 17916596 18633355 19411070 20038811 20184663 20435894 21133840 21411734 21826665 22595692 22955274 23170255 23430059 23508573 23510023 23567181 23769623 24092389 24378531 26201938 8910423
TNF TAB2 â—¼   ENZYMATIC_REACTION ✅ 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
TNF MAP3K7 â—¼   ENZYMATIC_REACTION ✅ 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
JAK2 TNF â—¼   DOWN_REGULATES ✅ - 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
HDAC1 TNF â—¼   DOWN_REGULATES ✅ - 15.0 1.0 ACSN 10754326 10952726 11875494 12907458 14660645 14668329 15465827 15644117 16878026 17404308 17485448 21234400 22796940 23390297 7594497
TNF CCR2 â—¼   DOWN_REGULATES ✅ - 34.0 1.0 ACSN 10623817 10925299 11112697 11438547 11875494 12646658 12811837 1431106 14607933 14625680 15099563 15699106 16713974 17916596 18633355 19411070 20038811 20184663 20435894 21133840 21411734 21826665 22595692 22955274 23170255 23430059 23508573 23510023 23567181 23769623 24092389 24378531 26201938 8910423
LITAF TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 22138218 12177065 11708771 10200294 16804395 16872372 17283168 12655064 21980379
SP1 TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 23733894 12759366 27030318 22534375 7649977 12509451 12378384 15175554 18357389 10829018 11390427 17897957 18218727 8258705 12560487 17047073 21320120 7918637 16847329 10559188 18930140 20068037 1618817 21784970 10688670 10913190 17307735 18467438 21411747 11500175 20221720 20701940
NFKB1 TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 74.0 1.0 Omnipath 17513725 12058956 24337575 12657243 17704137 12471036 17707233 7624137 11259437 12686724 16433741 26114754 20237317 7876168 16707469 12117498 14976218 10485496 15465827 8622636 15812247 21138578 18990758 10748079 15013838 15749903 16916598 17646159 10754326 16040075 10837498 18285351 11675405 11739517 15743782 20066113 20617556 17085785 8530146 8805669 10919279 14960579 1740105 10963848 16055086 9742085 17292554 10553096 11312646 15543947 17442180 16285952 10079106 11297551 10551799 10201927 12907458 8679226 9281604 22782967 8219230 11749970 9916895 11094063 11490006 7895918 1618817 16483936 18057724 20722069 16569682 9452482 17407192 17082635
NFKB1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10348347 11032029 8051093 12145335 20097177
TP53 BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 27.0 1.0 Omnipath 19363521 19470765 19067706 17124180 11714700 16432013 18698017 21443519 12235242 20236666 22266808 16595680 15361831 23838170 17916908 15087401 15377848 19018856 19439469 22503977 17699779 11965534 15657147 18022393 18027854
TP53 IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 15131018 11001824 12089352 20633551 24205274 17097318 10023442 17600529 17014845 8710868 12444079 16181796 22033326
TP53 HSP90AB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15052775 15284248 21478269
TP53 LITAF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10321740 21836606 17283168 15197774
TP53 CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10684646 20610713 17014845 11076533
TP53 HRAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21552926 9662334 11127813 21552928
TP53 IGFBP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10101800 23810988 15661074 7566179 15713654 18084616 9525742 20003326
TP53 PDGFRB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19952113 19763735 18697203
TP53 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 12732139 10618379 22264233 23706820 14514686 8183578 14761612 16138117 18593586 23063463 8119773
TP53 SP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 19846904 15790310 11118296 11384995 21611785 7478550 15967108 18419600 19244234 9865734 18769160
TP53 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12485897 18661553 19763735
TP53 FASLG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17196791 9889415 20393600 9841917
TP53 AFP â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 11572852 14522900 11798803 11891535 18212064 15743813 16203738 18573881 15657445 9891062
TP53BP2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 14985081 16139958 8875926 25502805 8016121 21513714 31515488 16713569 8668206 18275817 11839776
HDAC1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 17145710 10521394 11099047 22266186 20633551 18765668 20075864 17827154 11313951 14976551 25241761 19303885 12426395 19011633 16697957 16959611 16107876 10777477
MAPK9 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 79.0 1.0 Omnipath 12356735 14665630 26158765 18778462 12969974 12861053 15254178 17135248 18669630 12384533 17363488 17698850 11283254 10706102 21454683 18931691 11551930 11397945 14612532 15064747 15963507 11175334 11423984 27147566 29234486 24657168 10581258 14517211 17353187 10673500 22030623 14527925 22728651 17525747 15629715 9393873 11447225 15671037 22285752 17245430 15140942 28673515 23871434 11078726 20041275 11896587 16731759 17121812 33514736 11861384 25431954 12810724 17967874 12955074 21832239 16818520 12756247 23798621 11526498 20009884 16713569 10202145 11850826 11896572 10710310 10570149 12959929 15269203 11583595 21148320
GSK3B TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 23840442 12064478 11709713 9372954 11483158 16552184 17570479 14744935 16713569 21929745 12048243 21900206
PRKAA1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 28797070 15866171
TP53 TNFRSF10C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 14623878 10435597 10933923 18431400
TP53 BIRC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19211844 11965534 11714700
TP53 IGFBP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 7566179 17409411 18431400
TP53 HSP90AB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 23443559 18431400 11707401 22939624
CXCL2 CXCR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 8702798 9260277 16189514 1379593 12964882
CXCL1 CXCR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 8702798 9195914 10699158 16189514 1379593 12964882
CSF2 CXCL1 â—¼   ENZYMATIC_REACTION ✅ 21.0 1.0 ACSN 10426994 11015446 11280761 11460167 11777960 11907067 12193690 12907458 14660645 15536084 16713974 17301840 18264787 20805416 21133840 21232017 21765015 22869907 24030977 24699077 24958845
NFKB1 CXCL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8530498 7479086 15958549 10530453 16040075 11112786
HDAC1 AXIN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21734722 17666529 15576399 22761862 22290435 19923891 20682799
AXIN2 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15611123 10966653 10911903 888800000547 9554852 22745173 9566905 22322943
NOG BMP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17145710 12478285
BMP7 ACVR2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 9748228 7790373 12667445
BMP7 ACVR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11282024 8006002 31619522 122976748006002 16189514 12297674
BMP7 BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15621726 106311828605097 8605097 10631182
BMP7 BMPR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 18342887 16446785 7791754 7644468
BMP7 ACVR2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9748228 23331499 16446785
BMP7 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 16189514 7791754 12297674 8605097
RHOC ACTB â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 21576392 15507212 22275430 16439214 23222643 24914801 22094460
ACTB RHOA â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 12805219 18001770 12732141 12429848 18923426
MAP3K7 PRKAA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16054096 16054095 15509864 19197243 17244528 18692468 15980064
RHOC ACTG1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 21576392 15507212 22275430 16439214 23222643 24914801 22094460
RHOA ACTG1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 12805219 18001770 12732141 12429848 18923426
BMP10 ACVRL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17068149
BMP10 ACVR2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16049014
BMP10 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16049014
BMP10 BMPR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15621726 16049014
BMP10 ACVR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 30246251 30246252 27252362 31127068
BMP10 BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15621726 31127068 16049014
TGFB1 ID3 â—¼   DOWN_REGULATES ✅ - 27.0 1.0 ACSN 11133108 11708773 12490555 14557817 15111329 15181457 15252039 15548370 16474430 16607286 16716598 17615296 17934056 18403754 19010789 19109155 19920116 20519943 20644162 21041997 21278795 21900405 21909923 22703233 7594497 9157999 9335507
SP1 ITGAV â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10504395 23319049 12136940 23345412
PDGFRB RASA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 11896619 1375321 23331499 8382774 1314164 7486683 1850098 10697503 16713569
TGFB1 TGFBR2 â—¼   PHYSICAL_INTERACTION 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
TGFBR2 FKBP1A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 20207738 7823948 21358634 23525077
TGFB1 TGFBR2 â—¼   SHARES_COMPLEX 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
TGFB1 TGFBR2 â—¼   ENZYMATIC_REACTION ✅ 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
CAV1 TGFBR2 â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 11102446 17517963 18458534 19411448 20855962 21051947 21150282 21729786 22411312 22874531 23907124 25364523 26828520
SP1 TGFBR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 18053089 11507078 22028617 15647279 11687969 10982796 12750289 15895377 10766860 9632722 15905358
SMURF1 TGFBR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 11278251 15221015 22298955 15761148 21572392 27048878 22949611
TGFB1 TGFBR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 122.0 1.0 Omnipath 1310899 22874531 8047140 11279127 22710166 7878020 16424049 17673906 24132110 18922473 22943793 12729750 16446785 20519943 7706250 15761153 7594497 15548370 15761148 15265520 19010789 26194464 7852346 12717440 17768418 19050695 11133108 14557817 11278410 19920116 22949611 22703233 23331499 23070005 20060931 17070508 21614932 1333888 10716993 16572188 20860622 11323414 21900405 12724770 8106553 23034983 26192618 2871107 12809600 11382746 21372296 20538542 16200688 11792802 26201938 24403530 15099563 11013220 17979848 21054789 23784029 15003992 20644162 8515656 7935686 11157754 20856203 18382895 15282297 18855897 9865696 21441952 10678166 16127449 21041659 10026191 22315516 12767520 17404308 19732719 20616810 21071413 17934056 12738796 18423981 21098712 19747910 9311995 15034927 11274345 12154066 18758450 24336330 21278795 26966341 9261125 16474430 15653932 18490733 8242742 19038247 19109155
TGFBR2 SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11278251 15221015 11163210
IL1RN IL1R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 20959797 17145710 8142597 2876877 24332029 7589429 11641511 9062194
TAB2 MAP3K7 â—¼   PHYSICAL_INTERACTION 25.0 1.0 ACSN 10391247 11280761 11460167 11477091 12620219 14633987 14660645 15082531 15125833 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20164171 21041997 21133840 21232017 22941947 23681101 24403530 24699077 24958845
TAB2 MAP3K7 â—¼   SHARES_COMPLEX 25.0 1.0 ACSN 10391247 11280761 11460167 11477091 12620219 14633987 14660645 15082531 15125833 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20164171 21041997 21133840 21232017 22941947 23681101 24403530 24699077 24958845
IKBKB MAP3K7 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 20300203 9744859 17047224 11460167 17496917 14514672
MAP3K7 IL2RA â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 10391247 11280761 11460167 12620219 14633987 14660645 15082531 15125833 15282297 16200688 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20060931 20164171 21041997 21133840 21232017 22941947 24403530 24699077 24958845
SMAD6 MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11737269 10748100
SMAD7 MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12589052
TAB1 MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 88.0 1.0 Omnipath 17145710 16289117 18180283 10838074 24912525 23934659 10882101 19556242 11259596 19026643 14670075 17299140 23331499 22158122 12372426 21903422 17560374 21071413 23180781 19775907 14743216 17348859 20200282 26432169 18988627 10094049 8638164 11809792 10702308 25241761 19232515 14633987 18456659 10921914 20538596 15590691 16845370 27468689 12975377 12242293 17172402 22167179 12429732 12624112 12859960 16260783 11460167
TAB2 MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 112.0 1.0 Omnipath 17145710 11477091 17301840 18180283 10838074 24912525 16251197 10882101 19556242 15125833 19955178 31250519 36130827 17363905 17158449 11259596 19026643 24699077 14670075 18641653 24061540 24403530 23331499 22158122 12372426 21903422 27426733 21071413 23180781 14743216 18021073 21133840 20200282 26432169 21232017 18264787 20194509 10391247 18988627 22081109 8638164 16799562 11809792 19232515 12620219 14633987 19161412 20538596 22941947 23681101 20932475 15590691 12609980 16845370 27468689 12242293 11280761 15082531 26192618 14660645 24958845 17172402 15327770 25642820 22167179 20164171 16603398 17384642 11460167 21041997
MAP3K7 PRKAA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16054096 16054095 15509864 19197243 17244528 20615388 18692468 15980064
MAP3K7 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 57.0 1.0 Omnipath 24911653 11129660 25195736 16006187 16260493 15502405 14530355 10779355 28159912 10094049 10837071 15836773 25659581 10195894 9689078 17363973 10807933 15214841 16186825 16493424 10022904 18316610 10187861 12547194 33895773 28475177 16301747 15691841 15620648 15327770 29748387 19632174 11460167 17965022
TAB2 TAB1 â—¼   PHYSICAL_INTERACTION 16.0 1.0 ACSN 10391247 11274345 12620219 14660645 14704854 14960582 15082531 17127310 17884187 18264787 18762249 18855897 19020754 19136967 20194509 23070005
TAB2 TAB1 â—¼   SHARES_COMPLEX 16.0 1.0 ACSN 10391247 11274345 12620219 14660645 14704854 14960582 15082531 17127310 17884187 18264787 18762249 18855897 19020754 19136967 20194509 23070005
SMAD7 TAB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 17384642
TGFB1 SMAD7 â—¼   UP_REGULATES ✅ + 27.0 1.0 ACSN 11133108 11708773 12490555 14557817 15111329 15181457 15252039 15548370 16474430 16607286 16716598 17615296 17934056 18403754 19010789 19109155 19920116 20519943 20644162 21041997 21278795 21900405 21909923 22703233 7594497 9157999 9335507
SMAD7 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 10887185 15855807 9886263 20631490 22656308 19214138 23633623 14600158 10753944 11912247 11385614 11180003 17928287 19010789 22496417 22841502 17074765 15496141 11448947
SMURF1 SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 22773947 12151385 23331499 22921829 21071413 18988627 11278251 12408818 12519765 22152476 27292644 20937913 15221015 24700460 14722617 16720724 23959799
TGFB1 SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 19010789 14718519 16474430 17934056 20519943 9335507 21900405 11133108 14557817 15548370 19920116
SMAD7 TAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 11737269
SMAD7 SMURF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 26435193 22773947 15231748 23331499 22921829 16641086 17719543 21791611 26679521 11163210 27292644 20937913 15221015 18448069 22624557 32283253 23973329 16061177 14722617 19352540
JAK2 IFNGR1 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
JAK2 IFNGR1 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
IFNGR1 JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 11438544 15864272 17063185 23898330 12040185 7499845
JAK2 CSF2 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 11015446 11306493 11777960 11867689 12393492 12811837 14610620 19833085 20406969 20805416 21765015 22323450 22869907 23046136 24030977 24091328 27216177
JAK2 IL4R â—¼   PHYSICAL_INTERACTION 40.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26755705 27216177 2965306 7512720 7521688 7543512 9535722 9834059
JAK2 IL4R â—¼   SHARES_COMPLEX 40.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26755705 27216177 2965306 7512720 7521688 7543512 9535722 9834059
JAK2 CSF2 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 11015446 11306493 11777960 11867689 12393492 12811837 14610620 19833085 20406969 20805416 21765015 22323450 22869907 23046136 24030977 24091328 27216177
JAK2 IL4R â—¼   ENZYMATIC_REACTION ✅ 40.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26755705 27216177 2965306 7512720 7521688 7543512 9535722 9834059
JAK2 INHBA â—¼   DOWN_REGULATES ✅ - 32.0 1.0 ACSN 10485906 11867689 12223527 12401408 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26755705 27216177 7512720 7521688 7543512 9535722
MPL JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 24931576 23331499 10918061 7534285 10224114 10979953 7543416
IL4R JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 8609418 18852293 12223527
LEPR JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 17145710 23331499 30044226 17312100 8608603 18718905 12657512 21166956 9092791
JAK2 MAP3K5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19287004
JAK2 CCR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9670957
TGFB1 FKBP1A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 20207738 7823948 21358634 23525077
SP1 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 12186868 9580699 2808430 12615726 22415074 27974707 12138160 10964912 9242631 15178441 23437118 23936544 11114293 8325508 16714330 11278686 10212284 9837963 11054406 23806282 15979845
SP1 HRAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 8106522 8208618 3012774 11559711 21931711 8027084 1776841
RASA1 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 10769036 11389730 23331499 18829532 7628625 9219684 10592173 8663024 16713569 26721396 8360177 8537347 1904555 10394594 2833817
IGF1R RASA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18988627 23331499 7642582
AXIN1 WNT3A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
GSK3B AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 102.0 1.0 Omnipath 20128690 16944320 11738041 20043192 12511557 11967263 16890161 22613765 14663202 23602568 8524413 24451375 19303846 12554650 8638126 22509369 18593713 16199882 21988832 23331499 19759537 10428961 9482734 22270359 19202075 17570479 16293724 15327768 10581160 17318191 11487578 22773187 26496610 16568235 17318175 19131971 15465828 26912724 25241761 24976009 21242974 22682247 10228155 23579495 12584189 23959799 15020233 10421629 10488109 11278246 9501208 18632848 10481074 10535959 10318824 9554852 17601533 9832503 21502811 9734785 23455922
SMURF1 RHOA â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 14657501 14722617 14744429 15265520 15761148 16472676 21572392 22949611
SMURF1 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 14701756 17676934 15221015 19914168 21708152 22298955 24828823 19917253 16611643 17510966 15761153 22670624 22152476 17289590 15231748 21685363 27447855
SMURF1 RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 15761148 21572392 16472676 16622418 28658604 15710384 14744429 14657501 22949611
SMURF1 SMAD5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 17676934 20484049 11278251 15221015 19914168 22298955 18641638 22670624 15231748 12857866
SMURF1 RUNX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17145710 14701828 16299379 12738770
HDAC1 BMI1 â—¼   UP_REGULATES ✅ + 22.0 1.0 ACSN 11283614 12545156 12668723 15151915 15155580 15465827 16232121 17055429 17508028 17550342 20027199 20713526 20818389 21234400 21733352 2191300 21919891 22370643 22796940 23140366 23869868 9618481
NFKB1 BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17553314 20126979 14739605 23838170
SP1 BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 17350596 17876054 21131823 18175117 20660371 22334592 22734486 21433308 22773958 21093004 19120021 17124180
NFKB1 FASLG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 14563113 12655294 15160330 16770006 10671224
SP1 FASLG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 10075666 20617570 11254710 11053446 14563113 10754388 18293083 15659839 11970950 12655294 17192273 11745351 15173177 15004200 10671224
CSF2 IL4R â—¼   ENZYMATIC_REACTION ✅ 21.0 1.0 ACSN 10426994 11015446 11280761 11460167 11777960 11907067 12193690 12907458 14660645 15536084 16713974 17301840 18264787 20805416 21133840 21232017 21765015 22869907 24030977 24699077 24958845
IL4R INHBA â—¼   DOWN_REGULATES ✅ - 32.0 1.0 ACSN 10485906 11867689 12223527 12401408 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26755705 27216177 7512720 7521688 7543512 9535722
NFKB1 CSF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9190901 11418664 12760745 8135780 8934574 14741709 18285351 10608823
IGF1R MAP3K5 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10086337 10826997 11274345 12175651 12444011 12556535 12655147 12767520 16931767 17145802 17673906 19030972 21540285 24103846 24782617
AKT2 MAP3K5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 14500571 23603750 12697749 11154276 27363949
AKT1 MAP3K5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 16532036 14500571 11154276 30677014 17184578
RHOA ROCK1 â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 11698448 11729192 11739775 11992112 12194823 12361600 12740575 14657501 14744429 15761148 17517963 18037882 18423981 20535745 21178402 22949611 24857661 24919149 26885855 27048821 27066895 7479854 9362522 9660866 9822605
ARHGEF2 RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 9789025 22072711 32203420 9113980 9641915 10592173 9857026 20810787 16189514 24525234 11149925
RHOA ROCK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 55.0 1.0 Omnipath 17145710 12361600 25010901 23151663 7479854 27048821 22949611 21281639 26885855 8798490 12727213 17673200 11729192 8816443 10592173 11698448 27066895 11739775 11992112 20535745 18423981 24857661 21178402 23109003 9660866 9822605 17517963 14660612 15774750 12740575 14744429 9535835 12773565 15761148 24919149 26192618 9362522 18037882 14657501 12194823
SMAD6 TAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 11737269
CDK8 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19914168 19914161
RHOB ROCK1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11283606 15699075 8816443 11294240 8617235
SP1 CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15531587 10684646 23280667 21631282 17108117
SMURF2 SMAD5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 20484049 15221015 22298955 15231748
SMURF2 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 14701756 23331499 15221015 11016919 22298955 11158580 32296183 15231748 20937913
SP1 ID1 â—¼   UP_REGULATES ✅ + 21.0 1.0 ACSN 10048576 10964912 11007770 11013220 11114293 15001984 15592504 16079281 16556862 16716598 16831886 17490644 17705132 18353785 18832382 19564415 20589835 21252118 22439866 23338822 8844971
SP1 IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 10720440 21447702 7497000 15345673 17170218 7491107 17049831 17014845 10982795 17486080
SP1 CTSL â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11742542 14563703
SP1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19145069 15342781 21520171 18353772
SP1 IGFBP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12200149 11517158 15247904
IGF1R YWHAG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12767520 10826997 12444011 21540285 17145710 17353931 19030972 16931767 15324660 12175651
AKT1 BMI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22505453 23092893
AKT1 PRKAA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 19376078 16340011 16083285 26506913 27784766 24467442
AKT1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 99.0 1.0 Omnipath 17428466 15207235 17145710 12052830 10729337 8250835 11756412 11923280 16914735 17623045 16697215 8524413 12054501 20398329 18372248 21506126 20028971 12040186 15808505 16543730 20138985 23331499 21303971 16009706 10385618 20214616 23180781 9373175 16039586 15829723 18988627 16282323 11577096 11035810 18669648 18216173 15169778 12851486 16123141 11882383 23109003 9065430 18691976 22094462 10949026 22710759 11715018 12459251 18636226 17192257 11254732 11278246 20858269 9812896 9582355 15023346 17680028 19369195 7945242 12900420 23552696 18387957 10722653 20832730 18570873 12147701 18505846 17052453 17693255 18218901
AKT1 AKT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11546794 14500673 12176337 11445557 9736715 12149249 11278835
AKT1 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15184909 25241761 22689577 15856005 10485711 17660512
AKT1 YWHAG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 20138985 15169778 9812896 17680028 11756412 11923280 20214616 16697215 10949026 10722653 20832730 18570873 18372248 11715018 20398329 17052453 18636226 15808505
MEF2C BMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23632743 24866243 20412016 23314833
MAPK7 MEF2C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 11238956 9069290 20936779 25689862 23331499 22661957 21071413 9384584 9753748 12640115 16189514 18988627
IKBKB NFKB1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 9315679 9914500 9721103 10593898 9135156
NFKB1 PRKACB â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17462920 12628924 19197368 19122653 18385332
NFKB1 SRXN1 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 18761713 19027064 19747488 21725609 23178297 23572150
NFKB1 BIRC3 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 21725609 23178297 23572150 9294162 9733516
NFKB1 BIRC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 15231833 15050749 19343319 17673602 17000776 11880364 10733571 9733516 18566231 12010810 15723831 10823821 11297551
NFKB1 CXCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17363596 28266569 15132979 15722553
NFKB1 EBI3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9733827 15728491 24214980
NFKB1 IL2RA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 1777483 9135552 11781710 8455627 8029023 7636248
NFKB1 BIRC2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15050749 17673602 12687011 15756023 9733516 12010810 18566231 16453001 20103608
IKBKB NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 57.0 1.0 Omnipath 31598684 11976329 16713569 10469655 29485707 26999213 12842894 10835356 27187478 27402796 18782567 27554194 12482991 25241761 10022904 15199157 19519322 15489227 19250910 15212693 11158290 11297557
GSK3B NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 26999213 12871932 11425860 24618402 18669648 17693123
SMAD1 SMAD6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10692396 17215250 22219353 22072987
SMAD1 ID1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18381431 15331632 20522807 12296825
SMAD1 BMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 14551209 11786386 21471203 19836350 11585340 22072987
BMPR1A SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11438941 24412244 19620713 9136927 16189514 11792802
GSK3B SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 18045539 25241761
ACVR1 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 19651622 9748228 23331499 9335504 10085121 10652350 9136927 10583507 16189514 11792802 18988627
BMPR1B SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 9748228 23331499 9335504 10085121 19620713 9766532 9136927 11792802 15212693
SMAD6 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23331499 9256479 9335505 9436979 21071413 18988627 11483516 12857866
MAP2K1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 17081983 21105670 16964243 14617795 30711629 18547980 8382613 17188038 17192257 15020233
GDF2 ACVRL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17068149 25237187
GSK3B DVL3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
GSK3B WNT3A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
AKT3 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 12851486 15023346 21303971 11882383 17680028 9065430 23109003 20214616 22094462 23552696 20398329 21506126 20028971 12040186 18218901
AKT2 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 17145710 21303971 11882383 17680028 9065430 20214616 22094462 23552696 12434148 20398329 21506126 26051358 16293724 20028971 12040186 9712142 18218901
CCL3L1 CCR5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 11170631 10364178 10477718 16298345 11734558 11449371 11700073 9790730 22633458 12964882
AMH ACVR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 14656470
BMPR2 ACVR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 21071413 16446785 7791754 7890683
INHBA ACVR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16189514 11266516
BMP6 ACVR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12297674
BMP2 ACVR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8006002 28977600
GDF2 ACVR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 27252362 19996292
ACVR1 SMAD5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9748228 23331499 10652350 10583507 16189514 11792802 10504300
BMP4 BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 7811286 8702914 11282024 8006002
BMPR2 BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 21071413 16446785 18756288 10712517 7791754
AMHR2 BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 16446785 14746809 11420127
BMP6 BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11401330 10504300
BMP2 BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 7811286 12700180 9872992 10712517 15064755 19229295
BMP15 BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15621726 12044914 12419820 1204491412419820
BMPR1B SMAD5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 19620713 9766532 11792802
INHBA ACVR2A â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11117535 8196624 15123686 8622651 9032295
ACVR2A GDF1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15485907 21229555 21356369 15150278 15531507
GDF2 ACVR2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22622516 19996292
TDGF1 ACVR2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 12682303
INHBA ACVR2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 11266516 10746731 1646080 11266510 24018044 9605406 12466190
GDF7 ACVR2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16049014
BMP2 ACVR2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17483092 10880444 21702718 17295905 25938661 20959140
BMP6 ACVR2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10504300
BMP4 BMPR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 8702914 23331499 21071413 16446785 12045205 8006002 7673243 7644468
BMP4 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 8702914 26330344 20860622 21054789 11241215 8006002 16189514 7644468
SMAD5 SMAD6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10692396 16436528 22219353
INHBA FST â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 7678220 8033815 12697670 1592877 16198295
FST INHBA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 16198295 24627466 7887917 22037168
NOG BMP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 10657699 12700180 19804412 15064755
BMP2 ACVR2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 23331499 20385559 16446785 28977600 15064755 18988627 17295905
BMP2 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 51.0 1.0 Omnipath 17145710 17483092 10880444 10712517 26330344 21054789 16672363 10881198 11263668 20860622 15064755 18937504 25938661 15621726 12700180 10692589 19804412
BMP2 BMPR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 10880440 23331499 11263668 23180781 18342887 16446785 10880444 10712517 7791754 17295905 25938661 24337809
GDF1 ACVR2B â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15485907 21229555 21356369 15150278 15531507
INHBA ACVR2B â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11117535 8196624 15123686 8622651 9032295
GDF2 ACVR2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15851468 27252362 26047946
INHBA ACVR2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 8622651 16446785 9202237
BMP6 ACVR2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 21071413 16446785 10504300
ACVR2B ACVR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 23180781 8622651 16446785 12364468 18988627
NKX2-5 GATA4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19479054 15653675 16137232
BMP5 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11580864 16189514
BMPR2 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18756288 7791754 10712517
BMP6 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11401330 12297674 10504300
GDF6 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9525338 160490149525338 16049014
GDF7 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16049014
BMP15 BMPR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15621726 23331499 12419820 16446785
GDF2 BMPR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 28646109 15851468
BMP6 BMPR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 21071413 16446785 11401330 10504300
GDF7 BMPR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16049014
GDF6 BMPR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 9525338 16446785 18988627 160490149525338 16049014
WNT3A DVL3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
INHBA ACVR1B â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11117535 8196624 15123686 8622651 9032295
INHBA ACVR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 81675688397373 8167568 8397373 16189514 9605406 7890768
INHBA BAMBI â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10918299
AMH AMHR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 8889695 23331499 8119126 16446785 18988627 79972308889695 7997230
WNT3A FZD5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17117926 22753465 24032637
TDGF1 GDF1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15485907 21229555 21356369 15150278 15531507
TDGF1 ACVR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19874624 11909953
GDF1 ACVR1B â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15485907 21229555 21356369 15150278 15531507
GDF1 ACVR1C â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15485907 21229555 21356369 15150278 15531507