Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
PRKCZ ATP1A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12671055
MEF2D MEF2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8798771 9858528
H2BC14 H2BC9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2BC9 DSG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2BC9 NFE2L2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
CAD RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
MYC H2BC8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12747840
ACTBL2 LIMA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
FXR1 ACTG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
ACTG1 RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
ACTN4 RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
ATAD3A RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
FXR1 CAMK2B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
JAK2 CAMK2B â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
CDC37 RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
GAPDH CDK5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
TBP CDK5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CORO1C RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AA1 DNAJA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8204010 21360678
HSP90AB1 DNAJA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22011577 21700222
DNAJA1 RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
ETS1 DUSP6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20097731
MAPK1 DUSP7 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 8209350 9788880
UBE2C ENO2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
FOS ETS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16189514 8557686
PIK3CA FOS â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FOS TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11350971 10984493
FOS MAPK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7588633 12134156
SRC FOS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17160021 22105363
FXR1 PML â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
FXR1 MAPK7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
FXR1 MYO5B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
FYN PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12670391 8621607
FYN GAPDH â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PRKACA GAPDH â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
GJA1 SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11035005 5213074
TBP GTF2A1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17495528 14675539
SRC HSP90AA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16844778 0604705103
HSP90AA1 RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AA1 RIPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17145710 14743216
HSP90AB1 YWHAB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
HSP90AB1 RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
MYC HSP90AB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11983916
HSPA8 RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TP53 HSPB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
HSPB1 PRPS2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NFE2L2 IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21127061 27211851
TFAP2A IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16616959 9480831
JAK2 PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11598010 12506011
JAK2 PRKACA â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 10477722 10949031
SRC JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17570479 17158356
TP53 KLF4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10749849 16713569
MAPK1 LIMA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 23188829
PRKACA MAP1LC3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20713600
MAP2K6 NFE2L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 32911434 16951197
MAP2K6 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11460167 10882101
MAP3K2 YWHAE â—¼   COLOCALIZATION 2.0 0.8 intact 9452471 5221876
STK38 MAP3K2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17906693
SRC MAPK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16580177 9924018
RAF1 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 20674547 15664191
MAPK1 RPS6KA2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12832467 16626623
MAPK1 RPS6KA1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12832467 16626623
MAPK1 RPS6KA3 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12832467 16626623
MAPK1 PTPRR â—¼   COLOCALIZATION 2.0 0.8 intact 10601328 8213378
RPS6KA1 MAPK1 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
MAPK1 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15778365
MAPK1 MEF2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9069290 9384584
RPS6KA3 MAPK7 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12832467 16626623
MAPK7 RPS6KA2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12832467 16626623
MAPK7 RPS6KA1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12832467 16626623
MAPK7 NR4A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18429814
TBP MAPK8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17074809 19620725
YWHAB MDM4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16511560 5218386
YWHAE MDM4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16511560 5218386
MDM4 TP53 â—¼   COLOCALIZATION 2.0 0.8 intact 19521340 7290688
MEF2C NR4A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18079734
MYC PRKACA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15197457 12420224
MYC PRPS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18677108
NR4A2 NR4A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12529383 23331499
RPS6KA2 NR4A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11883936
NR4A1 NR4A2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12529383 23331499
PAK1 RAF1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 17097642 5219317
PDPK1 PRKCZ â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12840507 9889098
TP53 PML â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216620 12915590
PRKAR1A PRKACA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 24855271 1252328
PRKCZ RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16189514 10620507
PRPSAP1 PRPS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
TIMM50 RAF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216198 12620389
TUBB4A RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TIMM50 RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
RUVBL2 RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
SLC25A3 RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
YWHAE RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
RUVBL1 RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
SLC25A5 RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
YWHAB RPS6KA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216182 12618428
SRPK1 YWHAB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
YWHAB STK38 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
YWHAE TBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10449590
TP53 TFAP2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18980971 16636674
TP53 YWHAE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18812399 8008642
YWHAB MAP3K2 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 5217174 15324660
ACTG1 RUVBL2 â—¼   PHYSICAL_INTERACTION 812.0 0.81 STRING 36370105
TUBB2A TUBB4B â—¼   PHYSICAL_INTERACTION 819.0 0.81 STRING 36370105
MEF2B MEF2D â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
BAG2 RAF1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25036637 31980649
CDC37 PDPK1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25036637 31980649
MEF2B MEF2A â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
MEF2A MEF2C â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25609649 33961781
MEF2B MEF2C â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
MYC MYO5A â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 29467282 17353931
NTRK1 PTPRR â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25921289 28065597
HSP90AA1 SRC â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
TUBB2A TUBB4B â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
CDC37 RAF1 â—¼   PHYSICAL_INTERACTION 829.0 0.82 STRING 36370105
MYC DPM1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 21150319 17314511 29467282
MYC HSPB1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 21150319 17314511 29467282
MAPK1 PTPRR â—¼   PHOSPHORYLATION ✅ + 0.83 0.83 Signor 11493009
PTPRR MAPK1 â—¼   DEPHOSPHORYLATION ✅ - 0.83 0.83 Signor 11493009
CDK9 TP53 â—¼   PHYSICAL_INTERACTION 839.0 0.83 STRING 36370105
CDC37 CDK5 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 9150368 23455922 33961781 21163940
PML FOS â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 9671405 16189514
HSP90AB1 HSPA8 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
PFDN1 PFDN5 â—¼   CORRELATES + 0.84 0.84 CCLE 31978347
TUBA1B TUBB4B â—¼   CORRELATES + 0.84 0.84 CCLE 31978347
MAPK1 RAF1 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
HSPB1 TP53 â—¼   PHYSICAL_INTERACTION 848.0 0.84 STRING 36370105
ETS1 SRC â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 15788656 25117710
PFDN1 PFDN6 â—¼   CORRELATES + 0.85 0.85 CCLE 31978347
RPS6KA2 RPS6KA3 â—¼   CORRELATES + 0.85 0.85 CCLE 31978347
SLC25A4 SLC25A5 â—¼   PHYSICAL_INTERACTION 858.0 0.85 STRING 36370105
PFDN6 VBP1 â—¼   CORRELATES + 0.85 0.85 CCLE 31978347
RIPK3 CDC37 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 14743216 21903422
MYC PDS5A â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 29467282 17353931
MYC TBP â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 15723054 16713569 8755740
PFDN4 VBP1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HuRI 32296183
IVNS1ABP PRPSAP1 â—¼   PHYSICAL_INTERACTION 864.0 0.86 STRING 36370105
PFDN5 VBP1 â—¼   CORRELATES + 0.86 0.86 CCLE 31978347
ACTG1 RUVBL1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
MYC IPO9 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 17314511 29467282 17353931
JAK2 RAF1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 8876196 9689060 11134016 10205168
MYC MMS19 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 17314511 29467282 17353931
PRPS1 PRPS2 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
PRPSAP1 PRPSAP2 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
SLC3A2 SLC7A5 â—¼   CORRELATES + 0.87 0.87 CCLE 31978347
HSPA8 TP53 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
MYC PFDN5 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
CDK9 MYC â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
MAPK1 TP53 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
HSPB1 BAG3 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 25036637 32814053 25277244 26496610 30559338
RAF1 CDC37 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 25036637 31980649 16335536 24292678 24189400 17979178 32707033 16611982
CDK9 CDC37 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 20305087 25036637 23455922 24981860 27684187 26186194 28514442 24189400 32707033
MYC CDK9 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 17700062 12944920 30415952 26687678 19818711 11673469
DSG1 DSC1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 19136012 24981860 9606214
JAK2 FYN â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 10551884 16713569
TBP TP53 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
YWHAB YWHAE â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
PML TP53 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
MAPK8 TP53 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
DNAJA1 HSPA8 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
PFDN2 VBP1 â—¼   CORRELATES + 0.88 0.88 CCLE 31978347
HSP90AA1 HSP90AB1 â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
RAF1 YWHAE â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
MEF2D MEF2A â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 8798771 25609649 9858528 20590529
SRC FYN â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 16966330 31980649 28514442 19711372 9169421
RAF1 FYN â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 7517401 16189514 16713569
MYC PML â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 17146439 21150319 32592588 30415952 15735755
NR4A1 PML â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 12032831 16713569 16189514
PFDN2 PFDN5 â—¼   CORRELATES + 0.89 0.89 CCLE 31978347
MAPK1 ATP1A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15069082 14976217
MYC ACTG1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
BAG2 RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14978028 12502846 8692945
CDC37 SRC â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 32707033 31980649 11085988
MAPK1 DUSP3 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 intact 211739200 12840032 8214413
MAPK1 DUSP6 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 Reactome 17208316 22569528 20463170
DUSP7 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9788880
MAPK7 ELK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10473620
TFAP2A ETS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 1945412 8247540
TP53 ETS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15469934 14586398
TBP FOS â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 7685215 16713569 8065335 16055710
FOS PRKACA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10535756 1331087 1663213
FOS GJA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8606973 17895291 12064606
MYC FXR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
PRKACA FYN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20658524
FYN TUBA1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7678277 11826099
YWHAE GAPDH â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MYC GAPDH â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
HSP90AA1 TP53 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
MYC HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 28914785 12644583
HSP90AB1 NR4A1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
HSPA8 MAPK8 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MYC HSPA8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11983916 12695333
TP53 HSPA8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 31027880 18431400
NR1I2 KLF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19129222
MAPK1 YWHAB â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 27503831 16939974 9560161
MAPK1 RAP1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 27503831 16939974 9560161
MAPK1 RPS6KA3 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
MEF2C MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9069290 17210568 9988769
SGK1 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19447520
PRKCZ MAPK7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20538799 11158308
MAPK7 RPS6KA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 11544482 16626623
MYC RAF1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 28205554 17314511 28628118 9315742
TFAP2A MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9632747 8276360 7555706
MYC SLC25A3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
MYC PFDN6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
MYC UBE2C â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840 22170434
NR1I2 PRKCZ â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19129222
PAK1 RAF1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11733498 12551923 17097642 9823899 9234708 10205168
RAF1 PAK1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15520807 17462920 20363321
TP53 PML â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14992722 18056437 14715247
TFAP2A PRKACA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7958425 12169688 16790435
YWHAB PRKCZ â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
RAP1A RAF1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 9564038 8756332 7791872 9867809 10454553 7862125 16189514 9115221
SRC RAF1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 7517401 8876196 17097642 16189514 10205168
YWHAE RAF1 â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 8005785 11697890
TP53 SLC25A5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24076372 9671769 12080472
TP53 TMEM33 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16980608
PDPK1 SGK1 â—¼   PHYSICAL_INTERACTION 903.0 0.9 STRING 36370105
MAPK1 DUSP6 â—¼   PHOSPHORYLATION ✅ - 0.9 0.9 Signor 15632084
DUSP6 MAPK1 â—¼   DEPHOSPHORYLATION ✅ - 0.9 0.9 Signor 12840032
MAPK1 RPS6KA2 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
MAPK1 PTPRR â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
PFDN2 PFDN6 â—¼   CORRELATES + 0.9 0.9 CCLE 31978347
CDC37 CDK9 â—¼   PHYSICAL_INTERACTION 909.0 0.9 STRING 36370105
ACTG1 CDC37 â—¼   PHYSICAL_INTERACTION 0.91 0.91 HuRI 32296183
BAG3 HSPA8 â—¼   PHYSICAL_INTERACTION 916.0 0.91 STRING 36370105
FYN CDC37 â—¼   PHYSICAL_INTERACTION 0.92 0.92 HIPPIE 33961781 25036637 31980649 28514442 32707033
PFDN5 PFDN6 â—¼   CORRELATES + 0.92 0.92 CCLE 31978347
TUBA1B TUBB2A â—¼   CORRELATES + 0.92 0.92 CCLE 31978347
PRPS1 PRPSAP2 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
PRPS2 PRPSAP2 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
PRPS1 PRPSAP1 â—¼   PHYSICAL_INTERACTION 936.0 0.93 STRING 36370105
HSP90AA1 HSPA8 â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
HSP90AA1 RAF1 â—¼   PHYSICAL_INTERACTION 942.0 0.94 STRING 36370105
DUSP6 MAPK1 â—¼   PHYSICAL_INTERACTION 944.0 0.94 STRING 36370105
PRPS2 PRPSAP1 â—¼   PHYSICAL_INTERACTION 944.0 0.94 STRING 36370105
YWHAB RAF1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 19595761 8009093
BAG2 HSPA8 â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
TP53 MDM4 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 7290688 19521340
TP53 MDM4 â—¼   COLOCALIZATION ✅ 0.96 0.96 mint 7290688 19521340
TUBA1B TUBB2A â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
MAP2K5 MAPK7 â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
FYN SRC â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
PRKACA PRKAR1A â—¼   PHYSICAL_INTERACTION 968.0 0.96 STRING 36370105
SLC3A2 SLC7A5 â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
MAP2K5 MAP3K2 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
MAPK1 RPS6KA1 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
RAF1 RAP1A â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
CDC37 HSP90AB1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
PFDN1 PFDN6 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
PFDN1 VBP1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
PFDN1 PFDN4 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
PFDN1 PFDN2 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
PFDN1 PFDN5 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CDC37 HSP90AA1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PFDN2 VBP1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PFDN2 PFDN6 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PFDN2 PFDN4 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PFDN2 PFDN5 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RUVBL1 RUVBL2 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
MDM4 TP53 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PFDN4 PFDN5 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PFDN4 PFDN6 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PFDN5 VBP1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PFDN5 PFDN6 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PFDN6 VBP1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GTF2A1 TBP â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
MAPK7 MEF2D â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 18767875 18691976 20068231 9753748 16964243 10849446 18669648 16356933
MYC CAD â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 7739536 10931841 11673469 10657901 12177005 14519204 9111322 9811896 10567564 17706770 24771621 11983916
PRKACA CAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 37.0 1.0 Omnipath 19651622 17081983 1359877 18767875 17322306 18691976 4092695 19664994 20068231 18707149 23429703 11986331 17206380 14991569 19664995 18669648 33771897
MAPK1 CAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10659854 12438317 15890648
BAG3 HSPA8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 25036637 27474740 23824909 21233200 9873016 26496610 16189514 21423662
CAMK2B ETS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 12475968
TP53 CDK5 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 10604467 17591690 12064478 18490454 10500146
FYN CDK5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 24872417 19901323 9038181 10896159 18691976 20506281 29063113 20068231 16497976 19413330 14757045 12372285
CDK5 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 44.0 1.0 Omnipath 9372954 21317932 11483158 11740489 19413330 19664995 21600237 11554766 11709713 16552184 10884347 16377624 17591690 15866171 17287340 17967874 92065884 11780126 12064478 10570149 26146988 15701641 17117479 17108107 14702041
CDK5 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 10544291 12801906 19369195 18691976 9271228 21442427 27169346 17192257 29196663 19415658 7488156
CDK5 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 20058876 17114649 12176333 12950086 19298660 19664994 12176334 15542607 19413330 23537649 19036346 19664995 21825040 11604394
CDK5 MEF2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 16371476 16484498 22622902 12691662 12586839
CDK9 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 24173284 9372954 11483158 9315650 19413330 19664995 23603988 24202322 11709713 16083285 1088347 16552184 10884347 24286312 10747897 17942552 16741955 17287340 92065884 12064478 10348343 14702041
HSPA8 DNAJA1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 20084477 20809635 24012426 7828728 20072699
DUSP3 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 11971192 12204117
DUSP3 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 12840032 23331499 10224087 12204117 18988627
DUSP4 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 9020184 16038800 18988627
DUSP4 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 8626452 15315965 32296183 18988627 7535768
DUSP6 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12840032 23331499 8626780 18060821 8910287 8670865 9596579 14690430 15632084 9922370 17322878
ELK4 FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23063436 9734357 8764983 9111305 9130707 8986626 11846562 20637912
MAPK8 ELK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 9020136
ETS1 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 8552081 10358095 20534573 11782450 15572696
ETS1 FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9349499 8262053 1722028
ETS1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12145208 19022222 8649821 10510472
MAPK7 ETS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 8761310 12048211 20361728 25885538 8552081 11948414
MAPK1 ETS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 21494553 21449613 25241761 16045329 23991633 20361728 11570862 22521293 11948414
FOS RAF1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11274345 12738796 15067049 16393692 16394015 18039929 19667062 21385848 22634314 23430059 9064320
TP53 FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 8604347 17174366 8668332 1946467 10082525 10214938 1508692 8649776 10529369 12173040
FOS IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 10037779 10542237 9671466 2511437 25567680 20351184 24994901 11356008 11028561 12667961 18502099
FOS MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11939505 2463066 1696944 8276360 9950153 2139817 2498162 21607323 20410304 8490168 7654239
PRKACA FOS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 9920881 20068231 18452278 8248197 1545828
RPS6KA1 FOS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 15187187 21233202 9920881 23331499 7601337 16286006 20068231 18452278 18988627 16393692 8248197 1545828 15239952 16055710
MAPK1 FOS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 49.0 1.0 Omnipath 12134156 20506250 15547943 8248197 7816602 15084594 12697810 8226933 20068231 18452278 12738796 16393692 17255949 17439715 15187187 19541618 23109003 19565474 17722974 17052211 7588633 8545107 16055710 8388392 18039929 12972619 18775330 21098038 9604935 11274345
RPS6KA3 FOS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 15187187 21233202 9920881 15719069 12134156 16286006 16393692 8248197 17570479 1545828 15239952 23936765
FYN RPS6KA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18156174 12601080
FYN JUP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 14517306
FYN NFE2L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 23781297 24116287 27340506 27047795 23830626 19666107 23041058 28383481 26674355 27230643 23434765 27233051 29261130 16513647 19538984 25534706 26640614 17403689 28708100 20865015 21097520
MYC GAPDH â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 11274345 11283613 11283614 11704864 15199147 17055429 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 25002027 28536364
MAPK1 GJA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 22028470 9535909 19664994 9535905 12637502 15605363 8631994 17570479
SRC GJA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 33.0 1.0 Omnipath 24508467 19901323 16492141 21856279 10871288 11514593 10679481 15782139 9592087 16189514 30448479 30095367 19284610 26706150 30323740 27280719 9278444 24670366 15350848 16916748 23718910 22342665 15534005 29587860 23596415
MAPK7 GJA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 9535909 19664994 9535905 19701097 12637502 16189514 8631994
PIK3CA GOLGB1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 19345670 9918857 19438505 23168613 27795560 31066629 17764812 11027663
TBP GTF2A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 7969171 10675336 18206971 1644819 16412700 8051080 10581267 9566876 9003783 9603936 8751448 10617594 8552077 10078202 10523649 10985861 8626665 7823952 9343426
PRKACA GYS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 6263629 18691976 196939 2117608 19413330
TP53 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15358769 15284248 24451373 18996350
HSP90AA1 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 1310678 16844778 16189514 18266962
HSP90AA1 RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 25036637 19011619 16093354 8962087 18266962 8408024 23118896 22939624 24462205 16189514 17699868 20039095 16504566 20159553 17409432 16330544 15618521
HSP90AA1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 12427754 10557093 21460846 16713569 11507088
TP53 HSP90AB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15052775 15284248 21478269
TP53 HSP90AB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 23443559 18431400 11707401 22939624
SRC HSP90AB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17855507
PRKG1 HSPB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11383510 33524056 19593530 18720982 17570479 21131586 17351657
HSPB1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 25241761 16169070 16713569 17184779
JAK2 IL6 â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
JAK2 IL6 â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
JAK2 IL6 â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
SRC JAK2 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 11476890 12094222 16919435 17496910 17517963 25572304 26552706 27216177
JAK2 RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 11134016 8876196 9689060 10205168
SRC JUP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 8081883 14517306 23911551
MEF2A KLF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19106103 15988006 19696400 19696221
KLF4 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 18511453 16244670 17308127 21132436 17659301
MAP3K2 MAP2K5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 21988832 12912994 23331499 19903815 11073940 11274363 24975362 25861671
MAP2K5 MAPK7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 7759517 11544482 24975362 23612709 7646528 23331499 16189514 11782488 12011113 30132833 12912994 15917464 11242034 32296183 29483645 11739740 20667468 9790194 12628002 25861671
MAP3K2 MAP2K6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12738796 18855897 11274345 21614932
PAK1 MAP2K6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 7592586 11304531 15677464 11309380 14970210
MAP3K2 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8226933 15315965 17052767 11971971
RAF1 MAPK1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 25435214 20179705 20141835 16364920 20130576 15035987 25907612
MYC MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22789855 21933022 16596619 23617883 8013639 20144848
NFE2L2 MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19454702 23708697 17467702 21808062
PRKCZ MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11035106 12942541 23109003 12900386 15721486
MAPK1 PML â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 22935031 29416846 23293771 23316480 15093545
MAPK1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 10551811 17081983 8386367 17251036 91332050 17570479 1748630 7957875 27167001 15212693 1651323 15210690
MAPK1 RCAN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 17496910 18039929 19541618 21965663 24751678 19565474 15547943 12063245 12738796 11226259
MAPK1 RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 43.0 1.0 Omnipath 17081983 18767875 15849194 19690332 11409918 14654779 23331499 23180781 8226933 20068231 18988627 21917714 18669648 19541618 18691976 16407412 19933846 9922370 15664191 8388392 19651622 10801873 8349614 18775330 9604935
MAPK1 RPS6KA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 8939914 12832467 9915826 17906627 32296183 19282669
MAPK1 RPS6KA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 60.0 1.0 Omnipath 17081983 32814053 20385094 11532940 7601337 23331499 15342917 8939914 21071413 23047924 20068231 11335727 9687510 12618428 18988627 18669648 23519423 23109003 18691976 12594221 9915826 17906627 8202512 9430688 19651622 12832467 11500364 14966081 29997244 25730857 8387505 10411321 18212344
MAPK1 PTPRR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 26186194 16148006 25241761 10601328 10419510 9857190 18083107 11493009
MAPK1 NR4A2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17681692
MAPK1 NR4A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11883936
MAPK1 RPS6KA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 21988832 18156174 12016217 25241761 12832467 23602568 8939914 10480933 9915826 17906627 10980595 10856237 19282669
MAPK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 14965474 9765199 15116093 21675959 23443559 10781582 25241761 10446957 10958792 11409876 11709713 21147777 10673501 11551930 15867353 11875057 12091386
MAPK1 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 19604315 15542607 16964243 15212693 11604394
PTPRR MAPK7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 12042304
MAPK7 SGK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 19369195 18691976 16189514 11254654
MAPK7 MEF2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 23331499 9858528 10330143 9753748 16189514 27713878 18988627 17785444 10849446 12586839
MAPK7 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22046506 9461566
MAPK7 MEF2C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 11238956 9069290 20936779 25689862 23331499 22661957 21071413 9384584 9753748 12640115 16189514 18988627
MAPK7 PML â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 28153789 26539288 23730625 23316480 20832753
TP53 MAPK8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 22607268 23376463 18374905 15958553 10854211 22353755
PRKCZ MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10962008 8702918 18667433 17646398
MAPK8 YWHAB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 7890696 15696159 15071501
MAPK8 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 11108663 12531896 16713569 11283254 10706102 19651615 27147566 9724739 15538975 9732264 10581258 10436023 17570479 9393873 11896587 12514174 15580310 18813780 11078726
MAPK8 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 19651622 10551811 17081983 18767875 20068231 91332050 1651323 1748630 16713569 11243879 18669648 15210690
MAPK8 NR4A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 22002310 17023523
TP53 MDM4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 16492744 18172009 21750655 20036872 21422812 17510313 9926934 18336191 19521340 20372076 10469568 20080970 22290440 21394211 23474762
MDM4 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 74.0 1.0 Omnipath 25609649 18677113 28487147 24445145 30045945 20515689 26148237 22266850 11528400 19521340 21088494 16713569 15916963 9226370 12874296 21925390 16024788 25825738 24667498 16227609 24127580 8895579 20174603 18485870 12963717 15604276 25464845 12370303 10608892 23028042 25961923 26186194 17110929 22374672 26876197 17301054 23671280 21965653 17875722 22807444 10075736 19305137 17080083 29023092 27114532 20724842 10827196 19255450 24659749 28035068 23946421 20705607 19075013 21075307 12393902 11223036
MEF2A NR4A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10531067 11385620 10933397 23536182 10944115 11046135
TBP MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20886042 7880838 9797456 15876353 14506152
MYC TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 10962037 10656696 8494784 10348347 19882681 16557594 19086036 15780936 14519204 16112647 11781835 7969121 11789587 9839551
PPP2R5D MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19131971 10026142 10995457 18042541 18559511 16680151
RPS6KA1 NR4A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11274386 18669648 16223362
NR4A1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 23071566 17139261
PDPK1 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 11134074 21726627 21209852 10995762 23885116 26009991 26238471 10551809 25335797
PAK1 RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 67.0 1.0 Omnipath 28007610 19421139 26333361 22096607 15849194 12952546 30197477 12551923 23162742 25733387 17097642 22105362 18465753 23331499 24924700 10801448 26257058 21917714 12719581 11376654 25843685 15664191 19165420 23576562 23506953 10205168 24505617 28415790 18775988 22983922 9234708 12952943 16129686 25472536 11733498 11948406 9823899 11897507
PDPK1 SGK1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11500365 11687500 11747822 12670391 15802604 16286006 17680028 18802401 19109239 19122654 20932932
SRC PDPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 20643654 14585963 16314505 11481331 15212693 12738763 1148133 15302935
PDPK1 RPS6KA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 25241761 10480933 17906627 19956600 10856237 28314444
PDPK1 RPS6KA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 20058876 18767875 10480933 7642538 17906627 27028868 9430688
PDPK1 RPS6KA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19369195 10480933 17192257 17906627
PDPK1 PRKCZ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 12887331 14500673 11222751 18691976 10075713 20332120 9768361 9748166 17335005 10357815 16189514 11141077 16051884 11781095 10764742 14604996
PDPK1 SGK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 16286006 25384981 18802401 12387817 17916563 23331499 11807089 16189514 12023960 10191262 22042038 10357815 24760523 11500365 23317821 20932932 12912918 15209375 24864229 17680028
PDPK1 PRKACA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 16026785 20732331 15481030 22493239 10698939 9707564 8706898 20137943 21774789 17192257 22154087 20481595 12372837 16765046
SRC PIK3CA â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 12682286 15314172 20861220 18657504 11689445 12431978 25587652 11044445 22266855 11029403 11029009
SRC PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12750372 10592173 17275257 10830300
PRKACA PPP2R5D â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9688562 17110335 17301223 29294329
PRKAR1A PRKACA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 17145710 15655353 17353931 26687711 11834733 24855271 32296183 24700472 9405392 25477193
PRKACA TFAP2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10037142
PRKACA PTPRR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11749379 10601328
PRKACA RAP1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 8463283 9867809
PRKACA SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 19651622 17081983 20166139 2474754 18088087 15546918 19664994 11804588
PRKACA RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 53.0 1.0 Omnipath 19007248 11971957 20166139 18767875 20230923 9001246 10576742 23331499 20068231 7935389 18669648 18691976 9922370 15664191 19651622 12801936 9091312 10862777 9710607 11997508
PRKCZ SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 17496910 11940581 21386996 10527887 11447289 19615955 16488589 6321473 8321321 12845332 11313945 16189514 12040186 19568798 15567848 14585353
PRKCZ YWHAB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 16189514 10620507 21900206
PRKG1 PTS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10531334
RAF1 YWHAB â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 10358164 11532940 12566895 14764585 15516985 16102570 19289794 19565474 24027568 7510700 8551221 9069260 9763606 9846483
RAF1 YWHAB â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 10358164 11532940 12566895 14764585 15516985 16102570 19289794 19565474 24027568 7510700 8551221 9069260 9763606 9846483
SRC RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 7692235 12551923 7517401 17097642 15258589 9689060 16189514 16630891 10998357 11376654 29063113 8876196 10205168 28846113 12952943 22592532 11134016 15710605 16170185
RAP1A RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 9867809 9115221 7791872 12446733 8756332 16189514 7862125 12873387 10454553
RAF1 YWHAE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 19608861 16093354 16041367 11697890 8702721 16189514 25852190 7644510 15459208 17979178
RAF1 YWHAB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 8085158 12620389 16093354 19595761 7882972 16041367 24255178 11697890 7935795 8702721 10848612 16189514 25852190 7644510 12360521 10620507
SRC RAP1A â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 14754902 8755247 11940607 17218263 18434644 10964917 10446041
SRC RPS6KA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18156174 12601080
TP53 SGK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9058378 18430410 19756449 8647846
YWHAE YWHAB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 20936779 17085597 12507503 24255178 17979178
YWHAB YWHAE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 20936779 17085597 12507503 24255178 17979178