Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
IRF3 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21952047 23532979
CHD3 LUC7L2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
LUC7L2 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
LUC7L2 OFD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
HTT ATP5F1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ADRB2 SNCA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
ADRB2 LAMP2 â—¼   COLOCALIZATION 2.0 0.8 intact 7291579 19424180
ANAPC1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 8638126 9556553
CCT3 ANK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
HTT APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HSPA8 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MAP1LC3B APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SNCA APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MMP2 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CASP8 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CDK1 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CCT6A APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PINK1 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
APP PCNT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
CASP8 APP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10409650 10911620
IFIH1 ATG12 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0704014104 17709747
ATG4C HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
IFIH1 ATG5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0704014104 17709747
ATG7 ATG5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11265251
TP53 ATG7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1218395 22499945
BCL2L1 SNCA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CDK1 BCL2L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19917720
TP53 BNIP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21792176 11550088
EWSR1 BNIP3L â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
CLEC7A BNIP3L â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8153045 21516116
TP53 BNIP3L â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15607964
TP53 BNIP3L â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
TSC1 CALCOCO2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
GABARAPL2 CALCOCO2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
CALCOCO2 PTBP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
CHD3 CASP8 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
HTT CBL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RASSF1 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12024041
CCT2 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CCT3 XRCC6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
PPP2R1A CDK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8208439 17540176
HTT CHD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
XRCC6 CLTC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
TSC1 CTNNB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
CTNNB1 MMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17306568 12782598
CUL3 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
DDX58 TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16153868 19479062
DHX9 GGH â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
DYNLL1 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
EEF1A2 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
EEF1A2 TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
PPP2R1A EEF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8208439 17540176
HTT EEF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
KXD1 EWSR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
FASN EWSR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
PRUNE2 EWSR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
FASN HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TBC1D15 GABARAP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20562859
TP53INP2 GABARAPL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20010805 7714020
UBA5 GABARAPL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
GABARAPL2 TBC1D5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
GORASP2 MIF â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
HNRNPF HNRNPD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
PTBP1 HNRNPD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
HNRNPF TTN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
HSPA8 TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
OPTN HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11137014 5213395
HYPK HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
VCP HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PINK1 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TBC1D5 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TFG HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HTT PRUNE2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HTT UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SNCA HTT â—¼   COLOCALIZATION 2.0 0.8 intact 22119730 8292239
IFIH1 TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16153868 19479062
ITGB3 RABGAP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12606711 5216162
STX11 KXD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
MAP1LC3B KXD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
SCOC MAP1LC3B â—¼   COLOCALIZATION 2.0 0.8 intact 22354037 8398502
PINK1 MAP1LC3B â—¼   COLOCALIZATION 2.0 0.8 intact 20153330 7557104
MTMR14 MAP1LC3B â—¼   COLOCALIZATION 2.0 0.8 intact 19590496 7904087
TP53 MMP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
UBC NBR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19427866 7034152
UBC NBR1 â—¼   COLOCALIZATION 2.0 0.8 intact 19427866 7034152
UBC NEDD4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7104155 19343052
OPTN ZBTB48 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TP53 PPP2R1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219546 17245430
RB1CC1 TSC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16043512
VCP RNF115 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TRAF6 TAX1BP1 â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 17703191 5226445
VCP TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
VCP UBXN4 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
UBXN4 VCP â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
CCND1 CDK1 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
HNRNPL SRSF7 â—¼   CORRELATES + 0.8 0.8 CCLE 31978347
KBTBD6 KBTBD7 â—¼   PHYSICAL_INTERACTION 809.0 0.8 STRING 36370105
APP SNCA â—¼   PHYSICAL_INTERACTION 811.0 0.81 STRING 36370105
HNRNPD HNRNPF â—¼   PHYSICAL_INTERACTION 815.0 0.81 STRING 36370105
CASP8 TRAF6 â—¼   PHYSICAL_INTERACTION 816.0 0.81 STRING 36370105
DDX58 IRF3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 18636086 16153868
ATG3 MAP1S â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
HYPK CHD3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 16169070 23272104
CHD3 XRCC6 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30585729 28977666
DHX9 XRCC6 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30585729 15723802
WDFY3 FLCN â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
KEAP1 NBR1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30126895 33545068
TNIP1 NBR1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30561431 33545068
STX11 VAMP3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
MAP1LC3B NBR1 â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
GJA1 NEDD4 â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
GABARAP NBR1 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
RPS20 TUFM â—¼   PHYSICAL_INTERACTION 825.0 0.82 STRING 36370105
STK4 RASSF1 â—¼   PHYSICAL_INTERACTION ✅ 0.83 0.83 mint 24981860
CHD3 TRIM28 â—¼   PHYSICAL_INTERACTION 833.0 0.83 STRING 36370105
CASP8 CUL3 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CHD4 CHD3 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 24981860 28977666 22939629 32744500 9885572
STK4 RASSF5 â—¼   PHYSICAL_INTERACTION ✅ 0.84 0.84 mint 24981860
HNRNPL SAFB2 â—¼   CORRELATES + 0.84 0.84 CCLE 31978347
ATG3 GABARAPL2 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
SAFB2 SFPQ â—¼   CORRELATES + 0.84 0.84 CCLE 31978347
TRAF6 CASP8 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 16436380 27810922 16920630 30979779
CCT2 CCT3 â—¼   CORRELATES + 0.85 0.85 CCLE 31978347
GABARAPL2 LZTR1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HuRI 32296183
ATM PRKDC â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 10464290 10608806
CUL3 PRKDC â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 26949739 21145461
PCNT OFD1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 26496610 34079125
BNIP3 BNIP3L â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
DHX9 ILF2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 23986595 22863883 22939629
CALCOCO2 UBC â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
HSPA8 TP53 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
TAX1BP1 UBC â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
HNRNPD PTBP1 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
CHD3 CHD4 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
HTT OPTN â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
HNRNPL PTBP1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
CBL SLA2 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
TNIP1 UBC â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
ATG5 ATG3 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 20562859 24186333 28514442 33024031
ATM PEX5 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 10567403 26344566
PINK1 TRAP1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 31300519 17579517
PRKDC TP53 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
OPTN ZNF670 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HuRI 32296183
HTT VCP â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
UBXN4 VCP â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
CBL UBC â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
ILF2 PRKDC â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 9442054 17389650 20808282
MAP1LC3B NEDD4 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
STK4 MAP1S â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 23455922 24255178 24366813
DDX58 UBC â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
ATG16L1 RB1CC1 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
KRT16 KRT76 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
HNRNPL SFPQ â—¼   CORRELATES + 0.89 0.89 CCLE 31978347
ATG16L1 ATG3 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
CTNNB1 IRF3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 20453844 9541017 16154084
IRF3 IFIH1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12692549 16153868 16846591
DDX58 IRF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 28346439 26811330 16153868
ATG3 ATG12 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 11825910 32296183 20562859 20723759 17353931 24186333 23202584 30778222 28514442 34079125
WDFY3 ATG12 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20417604
TP53 ATM â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 9843217 9733515 9733514
DOCK7 BCL2L1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
BNIP3L BCL2L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10467396 9973195 16189514
CBL PPP2R1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11053437 12593796 12815057
CDK1 NEK9 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16079175 12101123 21642957
CDK1 RANBP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 26051540 17570479
KEAP1 CUL3 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 15367669 28186440 15572695 20864537 25742418 33130828 20534351 20027226 30765703 32854194 23727018 25628777 26757824 17439941 16449638 16790436 21357422 19818716 32341456 20421418 22245129 26219975 22558124 32296183 24896564 15983046 30383469 18251510 24127568 22911784 33391509 15282312 20865015 24322982 21145461 20599909 17822677 22448038 18417180 30273379 15601839
SNCA DOCK7 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
GABARAP TBC1D25 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21383079 26902585
TP53INP2 GABARAPL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20010805 19056683
TP53 GGH â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16980608
TP53 GSTP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18505928
PCNT HSPA8 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 25961502 2799391 2204156
TP53 HSPA8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 31027880 18431400
TP53 KBTBD7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16980608
TNIP1 OPTN â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 30561431 32296183 25416956 25910212 26871637 21988832 21516116 28514442 23414517 33545068
PINK1 TUFM â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 33113344
XRCC6 PRKDC â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 8422676 20711232 19303849 26175416 28345663 30585729 17308091 22939629 26496610 10750018 15941674 33005030 21969602 15520013 10064605 21575865 26446488
PRKDC VCP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16140914
SFPQ PTBP1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 8449401 15975576 17507659 16713569 10653975 11514619
RB1CC1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16061648 21775823
ATG3 MAP1LC3B â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
CCT3 CCT6A â—¼   CORRELATES + 0.9 0.9 CCLE 31978347
CCT2 CCT6A â—¼   CORRELATES + 0.9 0.9 CCLE 31978347
CHD4 CHD5 â—¼   CORRELATES + 0.9 0.9 CCLE 31978347
DYNLL1 GABARAPL2 â—¼   PHYSICAL_INTERACTION 0.91 0.91 HuRI 32296183
TRAF6 UBC â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
KRT16 KRT71 â—¼   PHYSICAL_INTERACTION 0.91 0.91 HuRI 32296183
ATM TP53 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
PINK1 UBC â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
ATG7 GABARAPL2 â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
ANK2 GABARAP â—¼   PHYSICAL_INTERACTION 929.0 0.92 STRING 36370105
UBC VCP â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
RASSF1 STK4 â—¼   PHYSICAL_INTERACTION 935.0 0.93 STRING 36370105
XRCC6 PRKDC â—¼   RELOCALIZATION ✅ + 0.93 0.93 Signor 19133841
ATG7 ATG12 â—¼   PHYSICAL_INTERACTION 0.94 0.94 HIPPIE 20562859 11890701 12482611 28253953 11096062
ATG12 ATG7 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
GABARAP WDFY3 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
ATG7 MAP1LC3B â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
GABARAPL2 UBA5 â—¼   PHYSICAL_INTERACTION 946.0 0.94 STRING 36370105
ATG7 GABARAP â—¼   PHYSICAL_INTERACTION 948.0 0.94 STRING 36370105
EEF2 SERBP1 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
RPL8 SERBP1 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
ATG3 GABARAP â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
BNIP3L BNIP3 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 10381623 6594431
UBC TP53 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 17568776 5220017
RPS20 SERBP1 â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
ATG12 ATG16L1 â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
PRKDC GGH â—¼   KO_DOWN_REGULATES ✅ - -0.97 0.96 PKG 28854368
ATG3 ATG5 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
BCL9 CTNNB1 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
MAP1LC3B OPTN â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
BCL2L1 TP53 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
OPTN UBC â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
NBR1 UBC â—¼   PHYSICAL_INTERACTION 979.0 0.97 STRING 36370105
PRKDC XRCC6 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
NEDD4 UBC â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
NEDD4L UBC â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
RASSF5 STK4 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
ATG3 ATG7 â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
EEF2 RPL8 â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
EEF2 RPS20 â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
ATG12 ATG3 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
ATG16L1 ATG5 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CCT2 CCT6A â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CCT3 CCT6A â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
ATG12 ATG5 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CCT2 CCT3 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL8 RPS20 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
PRKDC IRF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11867762
ATG101 RB1CC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20562859 23392225 19597335
DYNLL1 AMBRA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 27173435 20921139
CDK1 ANAPC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 19652693 18590585 7575488 16565220 17303408 12124778 17570479 17660363 14657031 15279786 15917306 15302935
ATG5 ATG12 â—¼   PHYSICAL_INTERACTION 7.0 1.0 ACSN 22093031 22166994 23030059 23301705 23725295 24070470 24257061
ATG5 ATG12 â—¼   SHARES_COMPLEX 7.0 1.0 ACSN 22093031 22166994 23030059 23301705 23725295 24070470 24257061
ATG12 ATG3 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 22093031 22166994 23030059 23301705 23725295 24070470 24257061
ATG7 ATG12 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 20562859 15197469 11265251 11890701 9759731 11100732 18704115 11096062 12482611
ATG12 ATG5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 11825910 20562859 17145710 12890687 17353931 22342342 9759731 9852036 23202584 11265251 12207896 12482611
ATG5 ATG16L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 20562859 23262492 22342342 20639872 23392225 12665549 23202584 18448665 25484072 28594407 10406794 21575909 22847423
RB1CC1 ATG16L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 20562859 23262492 23392225 24954904 24100292
ATG16L1 CLTC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20639872
ATG5 ATG3 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 22093031 22166994 23030059 23301705 23725295 24070470 24257061
ATG3 BNIP3L â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 22166994 23030059 23301705 23377657 23725295 24070470
ATG7 ATG3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15197469 11825910
ATG3 MAP1LC3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 20562859 11825910 17145710 16303767 11100732 11265251 17227760
ATG3 GABARAP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11825910 17145710 16303767 20562859
ATG3 GABARAPL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 20562859 17145710 17353931 16303767
ATG4A GABARAPL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12473658 17347651
ATG5 CASP8 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 11003656 15325588 17462996 20531300 23725295 24070470 26587781 26972597 28574505 9488730
ATG5 CASP8 â—¼   SHARES_COMPLEX 10.0 1.0 ACSN 11003656 15325588 17462996 20531300 23725295 24070470 26587781 26972597 28574505 9488730
WDFY3 ATG5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20417604
GABARAP ATG7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 20562859 17145710 11890701 16303767 11096062
ATG7 GABARAPL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 15197469 20562859 17145710 11890701 16303767 11096062
ATG7 MAP1LC3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 20562859 17145710 11890701 16303767 22170151 11100732
ATG7 GABARAP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 20562859 17145710 11890701 16303767 11096062
XRCC6 ATM â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
ATM TRIM28 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 73.0 1.0 Omnipath 25128619 22496453 34194047 30323812 26158765 16862143 28607002 19584288 20858735 28851455 18285803 34419074 17833484 22491012 25404613 21642969 28439615 27364555 27602502 26671524 23096706 23935532 28739276 24754998 25905708 28847822 24461736 23318425 23346550 17178852 27432546 27820601 17942393 21868291 32060145 22205726 25846574 26293668 25533843 23034801 23352131 28249048 23633913 17525332 18657500 24794298 23645696 26212333 23050241 22715096 27376578 23370278 24657165 29540829 25173936 19071136 28847828 20424263 34518220 25956864 23554604
ATM PEX5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 26344566 10567403 26967755
ATM TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20932475 21872579
ATM PRKDC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 47.0 1.0 Omnipath 17189255 12231622 17303408 24492479 10464290 22230547 15677476 16822724 28985363 29088817 16163361 32868446 19549901 25818648 22923485 19103741 17570479 27939942 19808981 23847781 22355272 24714417 15964794 21376743 31983282 25224041 16908529 12607003 19244120 17525332 15459660 34249431 28107384 12186630 25714019 11877377 26553138 27568553 19535303 15507430 26578593
ATM TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 452.0 1.0 Omnipath 25301947 21720806 23549171 10713094 16501611 15077171 24886358 17570479 19375142 22028490 16916644 14712210 19303885 9407038 11927276 26700820 28356518 15226429 10723129 19788889 12064478 19705844 26673821 22179422 20931131 19062161 27030982 22891162 17157788 19056039 15758953 12049739 15361830 26620371 25865756 22615843 10196661 10656682 11313957 25088203 15140942 12519769 16319535 24469230 12776195 17234789 27511909 29238697 24608431 12927814 16783362 11875057 16436515 22778557 15181149 12702572 10500142 15178764 28842590 28145533 11591448 17855337 22726545 20206688 26824362 21317290 26104798 24704793 9765199 11314044 16906133 17174997 21593792 17967874 10771484 15585169 19625493 15178448 17596534 16288207 15048074 18353733 24057508 19535302 29344296 23708100 29872395 23705030 25043304 33761896 18431490 21404020 15024084 22559321 12151394 24078877 12080066 33982778 16893723 10958792 18289945 27183917 26337656 29170437 18765533 10744722 21748595 18056442 24820418 15489892 16390936 24086335 28140789 23091651 34523970 32001619 23418564 15279808 21317932 21188172 27559048 16818505 17616578 11551930 19010925 11709713 24711418 28654064 18339864 11173129 17486112 10570149 29774100 18381438 21994612 29558908 15258567 9372954 25860929 16858402 33692124 15775976 34107253 19923893 24958101 10436023 14752509 19962312 19071090 26438152 26093282 20123963 22444248 9843217 17525332 15456784 23533526 11780126 20353948 29290977 11096068 28102346 18855897 20372057 24395704 23890999 15725625 15806145 34103468 18345031 16997395 16293623 28477117 19828454 27630139 12071847 22002314 21315088 27177180 12645530 12890678 26113041 15794754 18560558 22099307 9885574 28903382 15665826 24877058 18332866 10611322 24380814 14871840 19934315 22975381 16489034 18406507 21440540 33687951 10608806 23892398 20730097 16914171 15782130 15177184 22055193 18490454 25867001 24349352 18045533 20663147 17535811 20506250 23982736 22375140 15700044 15279774 19266268 24358288 18697815 14729946 20637859 12242661 12771937 17371838 31940492 19409520 10528155 24037342 17257427 11121242 15310764 23148227 28915641 26928575 21423215 11865061 16949371 27810895 18449195 20711232 27389279 22213803 16713569 10446957 22797063 16478990 29048667 15489221 17241873 21187893 21441950 23907539 20005840 9733514 26244501 21614094 12082529 10467728 10714958 32061892 16636671 29147215 10673501 12091386 25202122 21465263 19544417 25823026 24078903 24038750 22198295 21480565 15177039 28182994 28208785 18674635 20183804 18818083 9925639 17712528 15254178 11483158 27940348 26675349 26261212 19717643 12606585 24559687 14871926 23150668 21329876 28153791 12518062 12767922 23824039 11711532 19251701 28118604 15078887 12393500 17456577 20976220 23380594 12519780 20810927 15533933 22420423 17108107 20145032 18032786 18785202 22037398 23184057 31968249 16729035 12588868 21614932 11546806 18614045 14757188 15029243 14968111 22649771 25512053 34496248 18604166 17609585 17976513 16223874 25433195 18985806 9363941 15159397 34282274 29301278 24505404 26056062 23577291 18272544 18715874 19536869 29334356 10801407 15155458 25201202 24376853 19907922 23525106 14643431 28340339 28051100 19085961 15212693 22201816 20026654 16322229 20080565 9733515 15632067 18672098 22577550 25691451 12637545 12548019 11672523 26984736 12324477 16552184 22084686 10864201 14744854 21532626 17118344 19482562 9561848 12511424 17668048 23358251 18511169 21460853 22022355 12939400 21415014 17292432 25651062 23168260 12111733 16648554 30361254 23678107
ATM RASSF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 31175105 22438769 19962312 27322327 10608806 22389451
TP53 BCL2L1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 22869582 9582400 9989972 11713584 18172861 23519249 12705879 9000137 11713302
TP53 BCL2L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 24814347 12667443 16151013 26556313 14963330 16713569 20837658 24474649 21900206
BNIP3 BCL2L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16189514 10625696
PINK1 BCL2L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23953109 24013390 28486788 18974096 26188358 31367011 34064109 22617334 12633850 21840391 20363734 17369848 27398719
BCL2L1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 24814347 12667443 16151013 26556313 14963330 16713569 20837658 24474649 21900206
BCL9 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 17145710 15294866 23331499 11955446 17052462 15371335 24360964 15208637
CAPZB DYNLL1 â—¼   PHYSICAL_INTERACTION 28.0 1.0 Reactome 17274799 9490716 10679020 10562278 11306556 24891604 16723730 18086915 17283181 18664496 11035033 25453831 18046453 11285137 19564404 8642258 12198549 15728195 10903204 15878873 7691276 8909537 23839779 9150144 10559986 25233431 10036229 24806965
DDX58 CASP8 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18761323 16618810 11717445 12884866 16585540
CASP8 IFIH1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18761323 16618810 11717445 12884866 16585540
CDK1 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20937773
TP53 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 24189068 8702807 10669755 22270849 12808109 17942917 19086036 20731879 16061648 20554748 24460719 11798189 10082575 15205322 18769160 19800042
CTNNB1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 16628468 10318916 12095419 15111320 15735151 18679417 17360646 12782598 10201372 14557550 19778454 20300972 19662654 12589056 11943708 10915780 17693601 15592430 17109766
CTNNB1 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 19751508 10318916 7542250 11967263 22290435 11836555 19623618 12663502 23343194 11955436 22270359 22761862 16039586 15810077 10201372 19020303 17143292 12051714 17208333 8666229 18974774 16940750 14712077 17666529 21285352 19619488 15377999
CDK1 TSC1 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 14551205 15279786 17303408 17660363 18414028 18590585 7575488
TP53 CDK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 10825186 11593387 12874009 19472317 10514438 11313928 16807237 8270002 17942917 9275177 20395210 11032828 19861536 12889596 19067706
CDK1 TSC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 11444800 14551205 18414028 20006582
CDK1 GJA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 22960107 23828237 22739962 22737133 17570479 15605363 9472011 24815185 26033246 17629739 16718370
CDK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 24173284 12767922 1584757 20661218 26029996 2141171 9467949 17570479 20808790 7862459 11327730 11078726 27726420 8357826 16713569 2156209
TRIM28 CHD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18082607 11230151 24018422 16169070 21642969
TP53 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 11564862 20697347 20729811 21691299 19411072 24473123 20064927 18245266 18758483 18372914
VCP CUL3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 33444648 11733065 28115426 15652483 10811609 29153394
CUL3 KEAP1 â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 15703371 16697054 17312394 17884153 18931676 19560419 19622404 19686080 19809470 19818716 19847258 23030059 23850759
CUL3 KEAP1 â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 15703371 16697054 17312394 17884153 18931676 19560419 19622404 19686080 19809470 19818716 19847258 23030059 23850759
KEAP1 CUL3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 20534351 30273379 15983046 24896564 15282312 17439941 32341456 26219975 32296183 26757824
TP53 FASN â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12734185 19861536
NBR1 GABARAP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 20562859 23022382 21620860 24879152 19250911
WDFY3 GABARAP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20562859 24668264
NBR1 GABARAPL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 20562859 23022382 21620860 19250911
MAPK7 GJA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 9535909 19664994 9535905 19701097 12637502 16189514 8631994
TP53 HTT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22399227 15996546 16978870 16278683
TP53 HTT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18431400 32814053 16713569 10823891
VCP KEAP1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 33444648 11733065 28115426 15652483 10811609 29153394
KEAP1 MAP1LC3B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 20452972 20495340 22872865 15983046
MAP1LC3B NBR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 20562859 23022382 21620860 24879152 19250911
TP53 MMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 18980971 22451655 23048035 10029407 9343394 19853299 11792711 19939245 17088079 17258390
PINK1 TRAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17579517
PINK1 UBC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 24784582 25857750
PRKDC TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 79.0 1.0 Omnipath 15355354 19398950 15254178 9372954 11483158 7862459 16713569 11875057 11551930 11883897 12548019 25168287 8502477 11709713 10446957 28145533 22726545 24886358 16552184 12242661 17570479 10196661 10747897 9885574 10673501 12091386 22355272 9765199 15489221 9561848 10801407 22504299 22444248 15177184 11042698 10358069 10470151 10606744 9744860 16397295 12959929 12064478 27130668 10951572 12111733 25937999 15381073 28102346 9363941 19918261
PRKDC TRIM28 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19444312 27432546 23370278
TP53 RASSF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 23779024 23038753 21364923
RASSF5 RASSF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11857081 16713569 22195963
RASSF1 STK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 20562859 17145710 24366813 26186194 14729613 26578655 24255178 20920251 22683405 15109305 23386615 17598981 21808241 23455922
STK4 RASSF5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 20562859 16892067 24366813 24255178 11864565 15109305 16713569 17517604 23455922
RASSF5 STK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 20562859 16892067 24366813 24255178 11864565 15109305 16713569 17517604 23455922
TP53 RNF123 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10562557 21422812 22085928 11593391
SEC23A TFG â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 17005010 23479643 12235121 19638414 25619252 21478858 22675024 17192411 22157747 25586378
PRKDC ATM â—¼   KO_DOWN_REGULATES ✅ - -1.5 1.49 PKG 28854368
ATM ATM â—¼   KO_DOWN_REGULATES ✅ - -2.25 2.25 PKG 28854368
PRKDC PRKDC â—¼   KO_DOWN_REGULATES ✅ - -4.22 4.21 PKG 28854368