Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
UBE2L6 IRF3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20308324 16914094
IRF3 HERC5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20308324 16914094
IRF3 IKBKE â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20304918 21182093
IRF3 TBK1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 18583960 6948053
IRF3 TBK1 â—¼   COLOCALIZATION 2.0 0.8 intact 17599067 5220070
STING1 IRF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22394562 18818105
RBCK1 IRF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18711448
IRF3 ISG15 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12354379
IRF3 IFIT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12354379
TRIM32 STING1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22745133 21074459
IFIT1 STING1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19416887 0900818106
IKBKE STING1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0900850106 19433799
STING1 IFIT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19416887 0900818106
TRAF3 MAP3K14 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
STUB1 MAP3K14 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
DDX3X MAP3K14 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
UBC MARCHF5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16874301 5218876
MARCHF5 DDX58 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19484123
IFIH1 ATG12 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0704014104 17709747
IFIH1 ATG5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0704014104 17709747
TP53 CASP10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14688482
TP53 CASP10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14688482
MAVS CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16406812 21419663
CASP8 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11002417
CASP8 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11002417
YWHAE CBL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11697890 8005785
ITCH CBL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12226085 5215735
CBL SRC â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5219404 17141222
HSP90AA1 CHUK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
CHUK IKBKB â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 12799363 23430059
RIPK1 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18949366 24323043
TP53 CSNK2A1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12393879 11239457
IKBKE CYLD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18636086 6804508
UBE2D2 CYLD â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25565632 31366726
CYLD RIPK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 19131965 23010170
UBC CYLD â—¼   DEUBIQUITINATION ✅ 2.0 0.8 intact 19373254 7288828
CYLD IKBKG â—¼   DEUBIQUITINATION ✅ 2.0 0.8 Reactome 12917691 15620648
CYLD RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17981138 19131965
DDX3X TBK1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 18583960 6948053
DDX58 IRF7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15361868 19479062
DDX58 UBB â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
DDX58 TRAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16153868 19479062
DDX58 TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16153868 19479062
G3BP1 DDX58 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 30804210 22912779
IFIH1 DHX58 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0606699104 17190814
TP53 DUT â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19015155 12096336
TP53 EIF2AK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19416861 10082513
IKBKB EIF2AK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10848580 16600570
G3BP1 EIF2AK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25784705 25520508
FADD IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16227629 23131831
PRKCA HDAC6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8307255 21952047
SRC HSP90AA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16844778 0604705103
HSP90AA1 MAVS â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20628368 16394098
HSP90AA1 TRAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AA1 MAP3K1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AA1 IKBKE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AA1 IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
IKBKE IFIH1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0700544104 17600090
IRF7 IFIH1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15361868 19479062
TRAF2 IFIH1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16153868 19479062
IFIH1 TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16153868 19479062
IFIH1 IKBKE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0700544104 17600090
IFIH1 RNF125 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0611551104 17460044
PPP1CA IFIH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23499489
PPP1CC IFIH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25865883 23499489
TRIM25 IFIH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18353649
IFIT3 IFIT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
IKBKB TP53 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 19196987 0812256106
RIPK1 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21119000 18362886
TRAF2 IKBKE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
UBC IKBKE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18636086 6804508
IKBKE TANK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 intact 21212807 8142110
SIKE1 IKBKE â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16281057
UBB IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
RIPK1 IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10880512 5212735
TBK1 IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
PPP1CC IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
RNF31 IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24469399 21455180
SQSTM1 IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16874300
STAT1 IRF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15778351
MAVS IRF7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15361868 19479062
RNF135 IRF7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15361868 19479062
TRAF2 IRF7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15361868 19479062
TRIM25 IRF7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15361868 19479062
IRF7 TRIM4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15361868 19479062
SQSTM1 MAP1LC3B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
UBB MAP3K1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
MAP3K1 TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9008162 10465784
MAP3K1 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218828 16845370
YWHAE MAP3K1 â—¼   COLOCALIZATION 2.0 0.8 intact 9452471 5221876
MAP4K1 SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
MAVS UBB â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
MAVS UBC â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
TP53 PPP1CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
TP53 PRKCG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10614633 9895308
STAT1 PTPN11 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 10022928 18508557
PTPN11 SRC â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 8288622 20308328
TP53 PYCARD â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16715133
TP53 PYCARD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
UBE2K RBCK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RBCK1 RNF31 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
TRAF2 RNF135 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16153868 19479062
RNF135 TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16153868 19479062
TRAF3 SIKE1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16306936 16281057
UBC SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6504434 17936276
TRAF2 STUB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TP53 STUB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21478269 17666403
TRAF3 TANK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TRAF2 TANK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TRAF2 TBK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
UBC TBK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18636086 6804508
TP53 YWHAE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18812399 8008642
TRIM31 TRAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
UBB TRAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TRAF2 TRIM4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16153868 19479062
UBB TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
VCP TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TRIM4 TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16153868 19479062
UBE2K TRIM31 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
UBE2D1 UBB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22842904 21857666
UBC USP15 â—¼   DEUBIQUITINATION ✅ 2.0 0.8 intact 19373254 7288828
VCP UBE2D1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
OTUD5 UBB â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
CYLD UBC â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
UBD HDAC6 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 19033385 25422469 22797925 21090589
ITCH RPS27A â—¼   PHYSICAL_INTERACTION 810.0 0.81 STRING 36370105
UBC SQSTM1 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 5216530 12857745
TRIM25 UBB â—¼   PHYSICAL_INTERACTION 810.0 0.81 STRING 36370105
TRAF2 TRAF3 â—¼   PHYSICAL_INTERACTION 811.0 0.81 STRING 36370105
IKBKG MAVS â—¼   PHYSICAL_INTERACTION 812.0 0.81 STRING 36370105
ITCH TRAF6 â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
CASP8 TRAF6 â—¼   PHYSICAL_INTERACTION 816.0 0.81 STRING 36370105
DDX58 RPS27A â—¼   PHYSICAL_INTERACTION 817.0 0.81 STRING 36370105
ISG15 IRF3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 32726803 20308324
DDX58 IRF3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 18636086 16153868
TRI25 FBXW7 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25640309 31186535
MAVS ATG12 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22749352 17709747
MAVS CYLD â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30410068 18636086
CYLD DDX3X â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 27591049 31762063
G3BP1 DDX3X â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26777405 29395067
TRAF6 DDX3X â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 27507811 17353931
DHX58 DDX58 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17190814 31237466
TRAF2 FBXW7 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
HDAC6 G3BP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 32082291 18079183 21532619
MAVS PCBP2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25135833 19881509
OTUD5 TRAF3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 24763515 17991829
VAPA RAI14 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
TRIM25 UBE2D2 â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
HSP90AA1 SRC â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
RNF31 UBB â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
UBB UBE2D1 â—¼   PHYSICAL_INTERACTION 829.0 0.82 STRING 36370105
UBB UBE2L6 â—¼   PHYSICAL_INTERACTION 829.0 0.82 STRING 36370105
UBC UBE2L6 â—¼   PHYSICAL_INTERACTION 829.0 0.82 STRING 36370105
TM173 IRF3 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33086059 25636800 24622840 30018345
CBL ITCH â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 12226085 19341794
RIPK1 CYLD â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33654169 22848449 28900035 17981138 21408173
RNF31 CYLD â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 27307491 26670046 27591049 27458237 28189684 27545878
UBE2K DDX58 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 32513696 17719635
CYLD TRAF6 â—¼   PHYSICAL_INTERACTION 833.0 0.83 STRING 36370105
IKBKB SRC â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
USP15 USP4 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
CBL UBE2D1 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
TRIM32 UBE2D3 â—¼   PHYSICAL_INTERACTION 839.0 0.83 STRING 36370105
SRC CBL â—¼   PHOSPHORYLATION ✅ 0.84 0.84 mint 5219404 17141222
CYLD RIPK1 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
DDX58 RNF135 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
PRKCB RBCK1 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
RNF125 UBE2D1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HuRI 32296183
STAT1 SRC â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 14978237 10358079 9344858 16189514
SRC TRAF3 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 10635328 19419966
USP14 VCP â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
UBB UBC â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
PARK2 TRAF2 â—¼   PHYSICAL_INTERACTION 845.0 0.84 STRING 36370105
CYLD RNF31 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
HDAC6 UBB â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
RNF31 IKBKG â—¼   POLYUBIQUITINATION ✅ + 0.84 0.84 Signor 24469399
DDX58 WRIP1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 29053956 21903422
TRAF6 CASP8 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 16436380 27810922 16920630 30979779
TRAF6 IRF7 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 30927622 22095711 21743479 26224488 18710948 21183682 15361868
TP53 UBE2D1 â—¼   PHYSICAL_INTERACTION 851.0 0.85 STRING 36370105
UBB USP21 â—¼   PHYSICAL_INTERACTION 853.0 0.85 STRING 36370105
RPS27A TRIM25 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
TRIM25 UBC â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
IKBKG MAP3K14 â—¼   PHYSICAL_INTERACTION 856.0 0.85 STRING 36370105
HDAC6 RPS27A â—¼   PHYSICAL_INTERACTION 857.0 0.85 STRING 36370105
RBCK1 UBE2D3 â—¼   PHYSICAL_INTERACTION 859.0 0.85 STRING 36370105
RN125 DDX58 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 17460044 31827077
DDX58 TM173 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 18724357 22312431
DDX58 RN135 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 33373584 23950712 19484123 19017631 31006531
DDX58 PRKRA â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 28591694 23870315
VAPA FKBP8 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 32877691 26496610
MAVS FKBP8 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 32877691 30267576
TRAF6 SRC â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 22447928 10635328 16189514 29545793
ISG15 UBA7 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HuRI 32296183
TBK1 TM173 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 22745133 33086059 32383759 23542348 21903422 29899553 30943264 24622840 28763789 19433799 31534043 18724357 33139700 33767426 21074459 28346439 32678307 19416887
ATG5 MAVS â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 22749352 17709747
CASP8 TRAF2 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
HDAC6 CYLD â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 20593489 19893491
MAVS DDX3X â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 20127681 27980081
EIF2AK2 PRKRA â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
IKBKE TBK1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
UBA7 ISG15 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 17597759 32296183 14976209 16189514 18356159 16009940 16884686 22693631 25416956 20975683
MAVS TMEM173 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
TRAF6 TRAF2 â—¼   PHYSICAL_INTERACTION ✅ 0.87 0.87 mint 8153045 21516116
CSNK2A1 TP53 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
MAP3K14 TRAF3 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
TANK TRAF3 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
TRAF2 TRAF6 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
IFIH1 MAVS â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
IKBKE MAVS â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
ITCH UBE2D3 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
HDAC6 SQSTM1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
IRF1 STUB1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
MARCH5 UBE2D2 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
MAVS TRAF2 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
IKBKB MAP3K14 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
RPS27A USP21 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
IKBKE IRF3 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
IRF3 MAVS â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
IKBKB TRAF2 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
IRF1 STAT1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
IKBKE TRAF3 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
RBCK1 UBC â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
IRF7 IRF3 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11162841 18641315
MAVS TM173 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 23542348 20080758 24622840 18724357 22908223 22000020 22312431 19416887 22911572
CASP10 CASP8 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
CHUK TRAF2 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
TBK1 CYLD â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 18636086 25923723 29755980
MAVS IFIH1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33372174 16127453 19881509 21903422 30193849 17600090 22301138 27312109 33649232 22623778 19416887 32612200
IKBKG TANK â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
STAT1 IRF1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 16512786 10764778
TBK1 MAVS â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33372174 24643253 21903422 32511263 21813773 25636800 23028469 29125880 28346439 32366851 29743353 16153868
RIPK1 TRAF3 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 32296183 8612133
UBC USP15 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
CYLD IKBKG â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
IRF7 TRAF6 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
MAP3K14 TRAF2 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
IKBKG TBK1 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
MAVS TBK1 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
IKBKG RBCK1 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
IKBKE TANK â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
HDAC6 HSP90AA1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
PARK2 UBE2D2 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
UBC USP25 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
CBL UBC â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
MAVS DDX58 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 17190814 19454348 30193849 20007272 20406818 20434986 30558248 21292167 28594325 20080758 16177806 18200010 29053956 22301138 22022264 16153868 29263274 26494172 26061460 33372174 16585524 31433974 21844353 19164550 30267576 22623778 33976430 20071582 16127453 21903422 20554965 34544279 21102435 24478431 33649232 32612200 22114345 19193793 17709747
RPS27A UBE2L6 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
TRAF3 TBK1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 22792062 32779804 20174559 22908223 19380580 33187908 24763515 24622840 27135603 23308279 29125880 22079989 33411856 33372174 34084167 32324863 33608556 31404116 23717208 23986588 28049150 26928339 29920243 17991829 22330071
UBC UBE2D3 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
DDX58 UBC â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
PARK2 UBE2D3 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
ITCH UBC â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
TANK TRAF2 â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
STUB1 TP53 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
TBK1 TRAF2 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
RNF31 RPS27A â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
UBE2D2 UBE2K â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
PPP1CA PPP1CC â—¼   PHYSICAL_INTERACTION 899.0 0.89 STRING 36370105
TRIM25 IRF3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12692549 16153868 16846591
IRF3 RNF135 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12692549 16153868 16846591
IRF3 TRIM4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12692549 16153868 16846591
IRF3 IFIH1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12692549 16153868 16846591
IRF3 IFIT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11991981 18272581 12829834
IRF3 TBK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23843640 20304918 18636086
IRF3 IRF7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20483755 15367631 15664995
DDX58 IRF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 28346439 26811330 16153868
SNX5 PRKRA â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
TRI25 DDX58 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 30193849 20406818 23264040 21292167 25172487 28594325 34529741 17392790 34452305 31600868 31176400 32513696 19484123 29357390 30902577 23209422 30342007 34313226 20071582 29563291 24478431 20818395 23950712 31710640 34471099 22114345 28148787 27122586 19675569
TRI25 G3BP1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 26777405 29395067 29117863 34799561
IRF2 CASP8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17036321
SRC CBL â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 22203672 29899407 17141222 18996392 12941616 15135048 18273061 10829062 31120930 19861161 7782294 16713569 8635998 11994282 17094785 16636290
PRKCB CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12070292
TBK1 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10783893 21138416
TP53 DDX3X â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24180280 23584477 21325288
DDX58 SIKE1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10581243 12133833 19479062
DDX58 TRAF3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16858409 16306936 17190786
DDX58 TANK â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 19668221 19479062 17327220
DHX58 MAVS â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17020950
DHX58 IFIH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17020950
TP53 FBXW7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23518350 19366810 12824889
TP53 FBXW7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 31346036 12824889
HSP90AA1 TP53 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
TRAF3 IFIH1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16858409 16306936 17190786
SIKE1 IFIH1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10581243 12133833 19479062
TANK IFIH1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 19668221 19479062 17327220
IFIH1 TBK1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 23453971 22619329 24722368
IFIH1 TRAF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17020950 16306936 16858409
IFNG STAT1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12040185 7796299 8156998
IKBKG IKBKB â—¼   PHOSPHORYLATION ✅ 3.0 0.9 intact 8209688 506093200 16126728
PRKCB IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12070292
IKBKE TRIM4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 23453971 22619329 24722368
IKBKE RNF135 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 23453971 22619329 24722368
IKBKE TRIM25 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 23453971 22619329 24722368
MAVS IRF7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17020950 16153868
STAT1 ISG15 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16009940 17312100
TRAF6 MAVS â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 31390091 21903422 32511263 20080758 30527812 26221961 31806368 23545497 22908223 29125880 26385923 16153868 27348524
MAVS SIKE1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10581243 12133833 19479062
MAVS TANK â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 19668221 19479062 17327220
PCBP2 MAVS â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 25135833 19881509
TRAF3 RNF135 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16858409 16306936 17190786
RNF135 SIKE1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10581243 12133833 19479062
RNF135 TBK1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 23453971 22619329 24722368
RNF135 TANK â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 19668221 19479062 17327220
TRAF2 SIKE1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10581243 12133833 19479062
TRIM25 SIKE1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10581243 12133833 19479062
TANK SIKE1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10581243 12133833 19479062
SIKE1 TRAF6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10581243 12133833 19479062
SIKE1 TRIM4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10581243 12133833 19479062
STAT1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24655378 14602726
TRIM25 TANK â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 19668221 19479062 17327220
TANK TRIM4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 19668221 19479062 17327220
TRIM4 TBK1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 23453971 22619329 24722368
TRIM25 TBK1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 23453971 22619329 24722368
TP53 UBD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21396347 18431400
TRAF3 TRIM25 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16858409 16306936 17190786
TRAF3 TRIM4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16858409 16306936 17190786
ITCH UBE2D2 â—¼   PHYSICAL_INTERACTION 903.0 0.9 STRING 36370105
CHUK MAP3K14 â—¼   PHYSICAL_INTERACTION 904.0 0.9 STRING 36370105
UBB UBE2D2 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
CASP8 RIPK1 â—¼   CLEAVAGE ✅ - 0.9 0.9 Signor 10521396
IKBKG RNF31 â—¼   PHYSICAL_INTERACTION 909.0 0.9 STRING 36370105
TRAF2 RIPK1 â—¼   UP_REGULATES ✅ + 0.9 0.9 Signor 10795740
TRAF2 RIPK1 â—¼   UBIQUITINATION ✅ + 0.9 0.9 Signor 18621737
IFIT1 IFIT3 â—¼   CORRELATES + 0.9 0.9 CCLE 31978347
RPS27A UBE2D1 â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
TRAF6 UBC â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
PARK2 RPS27A â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
HSP90AA1 STUB1 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
PPP1CC WDR82 â—¼   PHYSICAL_INTERACTION 916.0 0.91 STRING 36370105
IRF3 TBK1 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
SQSTM1 TRAF6 â—¼   PHYSICAL_INTERACTION 919.0 0.91 STRING 36370105
TBK1 IRF3 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 17599067 5220070
TBK1 IRF3 â—¼   PHOSPHORYLATION ✅ 0.92 0.92 mint 6948053 18583960
TBK1 IRF3 â—¼   COLOCALIZATION ✅ 0.92 0.92 mint 17599067 5220070
CASP8 RIPK1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
IKBKG RIPK1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
RIPK1 TRAF2 â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
DDX58 TRIM25 â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
RPS27A TRAF6 â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
MAVS TRAF3 â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
SQSTM1 UBC â—¼   PHYSICAL_INTERACTION 926.0 0.92 STRING 36370105
RPS27A USP14 â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
OTUD5 RPS27A â—¼   PHYSICAL_INTERACTION 929.0 0.92 STRING 36370105
MAP1LC3B SQSTM1 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
UBC VCP â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
IKBKG UBC â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
PPP1CA WDR82 â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
CBL SRC â—¼   PHYSICAL_INTERACTION 936.0 0.93 STRING 36370105
MAP3K14 CHUK â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 16498412 5218365
TBK1 TRAF3 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
IKBKG TRAF6 â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
OTUD5 UBC â—¼   PHYSICAL_INTERACTION 949.0 0.94 STRING 36370105
TRAF3 MAVS â—¼   PHYSICAL_INTERACTION 0.95 0.95 HIPPIE 22792062 26221961 23545497 22908223 19893624 20080758 30527812 24622840 29125880 22022264 22079989 31390091 33411856 16858409 30267576 22901541 21200404 32324863 33608556 19419966 32511263 31806368 26519536 27980081 32366851 33582548 27348524
RPS27A UBE2D2 â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
UBB UBE2K â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
RPS27A UBB â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
RPS27A UBC â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
UBB USP14 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
PARK2 UBB â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
UBC TP53 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 17568776 5220017
RPS27A UBE2K â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
TANK TBK1 â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
STUB1 UBE2D3 â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
STUB1 UBE2D2 â—¼   PHYSICAL_INTERACTION 968.0 0.96 STRING 36370105
UBC UBE2D1 â—¼   PHYSICAL_INTERACTION 968.0 0.96 STRING 36370105
TBK1 TANK â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 33961781 31114588 30420664 23286385 18307994 23007157 21931555 17568778 32707033 30561431 10581243 29395067 14743216 21988832 17823124 25409927 24488098 16189514 29251827 27035970 21903422
HDAC6 UBC â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
IFIT1 IFIT3 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
TRIM25 UBE2D1 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
UBC UBE2D2 â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
RNF31 UBE2D2 â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
CBL UBE2D2 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
MAVS TRAF6 â—¼   PHYSICAL_INTERACTION 979.0 0.97 STRING 36370105
CASP8 FADD â—¼   COLOCALIZATION ✅ 0.98 0.98 mint 5219431 17159907
IKBKB IKBKG â—¼   PHOSPHORYLATION ✅ 0.98 0.98 mint 8209688 16126728 506093200
RNF31 RBCK1 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 5219147 17006537
TBK1 TMEM173 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
UBC USP14 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
RNF31 UBC â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
UBC USP21 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
DDX58 MAVS â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
RPS27A TP53 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
CASP10 FADD â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
PARK2 UBC â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
UBC UBE2K â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
ATG12 ATG5 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
FADD RIPK1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CHUK IKBKG â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
IKBKB IKBKG â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
STUB1 UBE2D1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CASP8 FADD â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
TRAF3 IRF3 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15210742 16281057 14703513 9566918 17157040
IRF3 STING1 â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 12133833 15210742 22394562 16281057 18818105 16306936 19926846 19776740 22579474 19433799 24560620
IRF3 ISG15 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19367472 8524823 12604599 9446577
TBK1 IRF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 90.0 1.0 Omnipath 24549848 18583960 22072751 16380379 26811330 16127453 17618271 23478265 19153231 12692549 28618271 17599067 22388039 15841462 25636800 21903422 15210742 33990776 20532218 16699525 20170763 30842273 12702806 16306043 17018283 20628368 16914100 33411856 23746807 28159912 16394098 18356163 22904301 34379517 22810896 14703513 22750291 27548204 29800227 22079989 24056301 14679297 17706453 20511230 24396068 19211767 18440553 16281057 12524442 16625202 9463386 19893624 18636086 15749911 18818105 27125670 24807708 15695821 9566918 30496178 17526488 19656901 23028469 32351706 24371060 15367631 16199137 25803835 24622840 16155125
IKBKE IRF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 16127453 19153231 12692549 24722368 15210742 20532218 12702806 16380379 14703513 29800227 14679297 17706453 24396068 18440553 16281057 16625202 9463386 18818105 16199137 9566918 15695821 14739303 21138416 17526488 15212693 16914100
MAVS IRF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17020950 25636800 21903422 16153868 22750291
IKBKB IRF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 25070846 20604809 9566918 14703513 19153595 27992402 18272581 16914100
MAVS STING1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 19416887 18818105 20080758 20019757 22312431 22844514 23542348 18724357 24622840 22911572
TBK1 STING1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 25254379 22579474 24929887 24119841 26199418 25815785 27857881 21074459 33723219 21903422 33906974 29899553 30018345 29241549 23542348 30193098 19416887 18818105 22394562 29202128 33789998 19433799 18724357 24622840
TRAF6 MAP3K14 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11274345 12150927 12620219 14660645 15125833 16252010 17948050 18264787 18758450 18922473 19161412
CASP8 MAP3K14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11002417 10753878
RIPK1 MAP3K14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11116146 15047705
TRAF2 MAP3K14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 9275204 11278268 23543740 18997792 20385093 25416956 15084608 10755617 16713569 9334169 25246529 20348096 20651737 20184394 9020361
TRAF6 MAP3K14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9275204 11278268 25241761 16286467 10921914 16189514 10075662
TRAF3 MAP3K14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 26.0 1.0 Omnipath 17145710 18997794 9275204 15208311 11278268 23543740 18997792 14743216 15084608 32296183 25246529 20348096
MAP3K14 IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 16189514 9927690 14743216
MAP3K14 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 17145710 11278268 10195894 9520446 14743216 9689078 9346485 16285893 10733566 10779355 10072079 11460167 10022904 10713178
MAP3K14 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 69.0 1.0 Omnipath 17145710 11278268 16498412 30833792 23915189 9346485 11520989 10072079 17563756 18515365 10887201 16223731 12556537 16286467 14743216 9244310 20348096 10094049 15140882 15208311 20685151 25241761 9742107 10229185 9520446 15084608 15994789 10713178 9819420 17150968 11239468 16691505 26948423 20651737 9020361
PRKCA MBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10460230 2413024
ATG5 ATG12 â—¼   PHYSICAL_INTERACTION 7.0 1.0 ACSN 22093031 22166994 23030059 23301705 23725295 24070470 24257061
ATG5 ATG12 â—¼   SHARES_COMPLEX 7.0 1.0 ACSN 22093031 22166994 23030059 23301705 23725295 24070470 24257061
ATG12 ATG5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 11825910 20562859 17145710 12890687 17353931 22342342 9759731 9852036 23202584 11265251 12207896 12482611
FADD ATG5 â—¼   PHYSICAL_INTERACTION 16.0 1.0 ACSN 11003656 11583996 15325588 16498403 17462996 20531300 22362782 23377657 23725295 23787782 24070470 26587781 26972597 27984721 28574505 9488730
ATG5 CASP8 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 11003656 15325588 17462996 20531300 23725295 24070470 26587781 26972597 28574505 9488730
FADD ATG5 â—¼   SHARES_COMPLEX 16.0 1.0 ACSN 11003656 11583996 15325588 16498403 17462996 20531300 22362782 23377657 23725295 23787782 24070470 26587781 26972597 27984721 28574505 9488730
ATG5 CASP8 â—¼   SHARES_COMPLEX 10.0 1.0 ACSN 11003656 15325588 17462996 20531300 23725295 24070470 26587781 26972597 28574505 9488730
FADD ATG5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15778222
DDX58 CASP10 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18761323 16618810 11717445 12884866 16585540
RNF135 CASP10 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18761323 16618810 11717445 12884866 16585540
TRIM25 CASP10 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18761323 16618810 11717445 12884866 16585540
CASP10 TRIM4 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18761323 16618810 11717445 12884866 16585540
CASP10 IFIH1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18761323 16618810 11717445 12884866 16585540
CASP8 CASP10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 22864571 17159907 17145710 12887920 11832478 11717445 21737330 15280356 12198154 3031469 15659383 170210 8962078 22421964
FADD CASP10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 16585540 17145710 15069192 12887920 9045686 11717445 9228018 20829884 15659383
CASP10 RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11002417 16186808 12887920
TRIM25 CASP8 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18761323 16618810 11717445 12884866 16585540
FADD CASP8 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 11003656 15325588 17462996 20531300 23725295 24070470 26587781 26972597 28574505 9488730
TRAF2 CASP8 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15024054 20696707 19278658 10837247 19416807 21235526
DDX58 CASP8 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18761323 16618810 11717445 12884866 16585540
CASP8 IFIH1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18761323 16618810 11717445 12884866 16585540
CASP8 RNF135 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18761323 16618810 11717445 12884866 16585540
CASP8 TRIM4 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18761323 16618810 11717445 12884866 16585540
FADD CASP8 â—¼   SHARES_COMPLEX 10.0 1.0 ACSN 11003656 15325588 17462996 20531300 23725295 24070470 26587781 26972597 28574505 9488730
IRF1 CASP8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17036321 14993214 22427665 23255602
SRC CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 27432652 16619028 19470771 27109099 27195913 19383910 30501030 24100030 22074016
IRF1 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14993214 19129219
TRAF2 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17145710 12887920 20203691 16227629 21741934 17047155 22421964 30054040 11340079
FADD CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 82.0 1.0 Omnipath 22864571 17145710 11717445 19524512 34591612 15280356 17047155 27552911 12911633 25043603 21458669 11788820 19176810 21525013 21988832 22179575 25939870 12702723 21737330 21741934 26437781 25911380 9228018 21785459 20829884 23972990 21620750 12220669 9774341 17159907 10521396 27321185 17290218 27560715 20103630 24098568 20203691 14612908 8681377 18485876 12107169 15659383 22421964 20448643 9343261 20125124 8681376 12887920 19060883 21737329 23142077 22173242 26972597 22274400 19935698 16410793
CASP8 RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 39.0 1.0 Omnipath 17145710 11002422 34389694 19524512 8657102 17047155 10469655 21458669 21419663 21525013 12842894 18570872 21741934 10521396 11002417 12884866 20203691 22421964 11042193 20125124 12887920 12215447 19935698
HSP90AA1 CBL â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 17177598 16187797 15284455 16849543 16969069 16953218 17699773 17372273 17712310
PRKCA CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10358153 17570479 25814554 11024037
SRC CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 50.0 1.0 Omnipath 9525940 7782294 16713569 18273061 10829062 10799548 10934191 12604776 9890970 17570479 9013636 15135048 17094785 25784557 8635998 10092522 12522270 8621719 17141222 16636290 11239464 19861161 11994282 12941616 14739300 22203672 8849724 15212693
IKBKG CHUK â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 11340079 12133805 12799363 15199157 15485931 16818229 17363905 17485448 17693255 18716620 20138012 20300203 20531300 21217011 22435554 23430059 28462531
IKBKG CHUK â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 11340079 12133805 12799363 15199157 15485931 16818229 17363905 17485448 17693255 18716620 20138012 20300203 20531300 21217011 22435554 23430059 28462531
TRAF2 CHUK â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 11274345 12847084 15592525 17462996 18641653 19392652 19509052 21133840 21232017 23430059 23850759 24378531 26587781
CHUK MAP3K1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 9008162 19666475 9689078 12221085
TP53 CHUK â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15469934 11557753 17434128
IKBKG CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 74.0 1.0 Omnipath 17145710 17485448 16938294 11865184 11877453 16970925 22435554 17244613 17568778 17363905 16818229 15084594 15485931 24369075 20300203 21217011 12799363 23180781 14743216 16319058 21703539 19666608 20098747 12612076 16126728 15218526 23430059 9751060 20138012 18716620 20368414 10837071 25355947 15836773 23109003 20531300 17702576 17363973 15214841 12459277 17561400 21640763 16285893 28462531 12709429 10968790 15199157 26192618 12133805 16497931 11864612 17693255 17072322 11340079
SRC CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17145710 12707358
MAP3K1 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18182252 9819420 9008162 10713178
TRAF2 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 15725726 12547194 11359906 25241761 20449947 9244310 16713569 23007157 10795740 24323043 19150425
EIF2AK2 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10723127 10648614
TRAF6 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15836773
CHUK IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 91.0 1.0 Omnipath 9346484 24911653 20932476 28514442 11971985 16970925 12210728 9346485 17965022 16713569 12486103 9891086 15456791 11057907 20434986 16129692 16260493 21903422 21724995 16286467 14743216 16319058 18949366 10779355 25748427 25852190 12244103 11585904 9751060 15218526 10094049 10837071 9914500 21575199 9721103 25241761 10195894 9689078 15214841 21784860 17561400 21640763 16285893 10733566 16186825 16493424 10022904 12709429 12351658 10968790 12547194 15691841 15620648 15327770 11864612 11460167 14636585 17693255 17072322 9346241
CHUK CYLD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19481526 24614225
CSNK2A1 OTUD5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 32071088 30232733 33417762 22245969
CSNK2A1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 53.0 1.0 Omnipath 23443559 15358769 9315650 19413330 11285227 11551930 11883897 22975381 11709713 16083285 1088347 33745968 16552184 10884347 10747897 10673501 7936649 12628923 25241761 21127074 16964247 24725084 10606744 10348343 10951572
CSNK2A1 DDX58 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 26354181 21068236
CSNK2A1 G3BP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 27022092 33065005 32302571 32302572 12642610 27083003 23163895 11604510 31171631 27920254
RBCK1 CYLD â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 26997266 27591049 27545878 24098568 27458237 27307491 22435550
IKBKB CYLD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 19481526 24614225 15870263
IKBKE CYLD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 19287453 18636086 27844253 20863366 19481526 29755980
CYLD TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 12917691 12917689 16230348 29933112 18382763
CYLD TRAF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 12917691 23405219 17851586
CYLD DDX58 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18467330 18636086
CYLD IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 21988832 15341735 15870263 22990857 12917689 12917691 16627981 20932475 26802121 12917690
DDX58 TRIM4 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 19017631 20403326 24755855 19484123 17392790
IRF1 DDX58 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17516545 22391244 21811588
TRIM25 DDX58 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 20406818 30902577 20818395 24478431 34471099 23950712 34452305 34529741 18353649 35075101 18948594 27122586 32513696 17392790
RNF125 DDX58 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17460044
RNF135 DDX58 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 19017631 23950712 19484123 35089988
DHX58 DDX58 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 17190814 16116171 17020950 16210631
DDX58 MAVS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 61.0 1.0 Omnipath 17145710 20554965 16127453 33372174 20007272 35075101 21419663 16585524 20406818 19052324 17020950 21903422 19164550 24478431 17190814 16713980 18200010 18948594 19193793 16177806 34544279 16153868 23843640 16785313 16301520 21844353 16125763 19036819 18977754 21102435 33976430 22301138 17709747 21200404 29263274 26494172 23499489 18207245 19881509 22844514 20080758
DDX58 TBK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 16177806 17020950 15210742 15210743 23950712 16306936 16127453 17468758 16281057 12702806 17327220 16858409 21419663
DDX58 TRAF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17020950 16306936 16858409 21844353
DDX58 IKBKE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 16177806 17020950 15210742 15210743 23950712 16306936 16127453 17468758 12702806 17327220 16858409 16281057
IRF1 EIF2AK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 7543195 8622878 9333018
PRKRA EIF2AK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 10988289 24778252 21903422 9687506 11985496 16785445 32296183 12368348 11238927 23455922
EIF2AK2 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23597922 9135145 11278865 16516295 10637230
EIF2AK2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 17451862 16083285 1088347 10082513 10348343 10884347 16552184 9315650 9737981 19413330 16713569 10747897
TRAF2 FADD â—¼   PHYSICAL_INTERACTION 74.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 1134007 11438547 11460167 11583996 11875494 12215447 12646658 12702723 12724420 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 15760909 16406523 16498403 16713974 16940415 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19597341 19632174 19838173 20038811 20184663 20435894 20452955 20531300 21133840 21232017 21411734 21826665 22427918 22955274 23010170 23069999 23170255 23377657 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 27984721 28574505 8910423 9488730 9759866
RIPK1 FADD â—¼   PHYSICAL_INTERACTION 90.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 1134007 11438547 11460167 11583996 11875494 12215447 12646658 12702723 12724420 12811837 1431106 14607933 14625680 14660645 14730360 14744430 15099563 15592525 15699106 15760909 16406523 16498403 16713974 16940415 17301840 17462996 17916596 18264787 18545270 18633355 18641653 19392652 19411070 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20038811 20184663 20435894 20452955 20531300 21133840 21232017 21411734 21826665 22421439 22427918 22955274 23010170 23069999 23073834 23170255 23377657 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24366341 24378531 24699077 24958845 26024392 26201938 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 8910423 9184224 9217161 9488730 9759866
TRAF2 FADD â—¼   SHARES_COMPLEX 74.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 1134007 11438547 11460167 11583996 11875494 12215447 12646658 12702723 12724420 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 15760909 16406523 16498403 16713974 16940415 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19597341 19632174 19838173 20038811 20184663 20435894 20452955 20531300 21133840 21232017 21411734 21826665 22427918 22955274 23010170 23069999 23170255 23377657 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 27984721 28574505 8910423 9488730 9759866
RIPK1 FADD â—¼   SHARES_COMPLEX 90.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 1134007 11438547 11460167 11583996 11875494 12215447 12646658 12702723 12724420 12811837 1431106 14607933 14625680 14660645 14730360 14744430 15099563 15592525 15699106 15760909 16406523 16498403 16713974 16940415 17301840 17462996 17916596 18264787 18545270 18633355 18641653 19392652 19411070 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20038811 20184663 20435894 20452955 20531300 21133840 21232017 21411734 21826665 22421439 22427918 22955274 23010170 23069999 23073834 23170255 23377657 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24366341 24378531 24699077 24958845 26024392 26201938 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 8910423 9184224 9217161 9488730 9759866
TRAF2 FADD â—¼   ENZYMATIC_REACTION ✅ 74.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 1134007 11438547 11460167 11583996 11875494 12215447 12646658 12702723 12724420 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 15760909 16406523 16498403 16713974 16940415 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19597341 19632174 19838173 20038811 20184663 20435894 20452955 20531300 21133840 21232017 21411734 21826665 22427918 22955274 23010170 23069999 23170255 23377657 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 27984721 28574505 8910423 9488730 9759866
SQSTM1 FADD â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 12702723 15340068 16252010 16498403 20531300 21981924 23069999 25002027 26587781 28574505 9184224
FADD IKBKG â—¼   ENZYMATIC_REACTION ✅ 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
MAP3K1 FADD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11034606 10640736 16061179 15001534
STAT1 FADD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10848577
FADD RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 16585540 22864571 26733177 11002422 11854271 19524512 21458669 21525013 21052097 26865630 21741934 23972990 21620750 26186194 27560715 24098568 20203691 16227629 32296183 18485876 32024820 22890322 11464215 21737329 12887920 21183682 19524513 26972597 19373245 22848449 24577083
HDAC6 HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19158084 18591380 18266962
UBE2L6 HERC5 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 16407192 17289916 16815975 16352599
ISG15 HERC5 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 16407192 17289916 16815975 16352599
STAT1 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 9880553 21430289 12940076 10440232
TP53 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15358769 15284248 24451373 18996350
PRKCG HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 26804907 24117238
HSP90AA1 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 1310678 16844778 16189514 18266962
HSP90AA1 RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10744744 17145710 12441346 14743216
HSP90AA1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 12427754 10557093 21460846 16713569 11507088
RNF125 IFIH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17460044
IFIH1 IKBKE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 16177806 17020950 15210742 15210743 16306936 16127453 12702806 16858409
IFIH1 TBK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 16177806 17020950 15210742 15210743 16306936 16127453 12702806 16858409
IFIH1 MAVS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 19416887 22301138 17600090 17020950 19052324 21903422 16410796 16785313 16713980 23499489 16127453 33372174 16125763
IRF1 IFIT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19351818 21056555 20137113
STAT1 IFIT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21056555 17050680 17933493
IFNG STAT1 â—¼   ENZYMATIC_REACTION ✅ 69.0 1.0 ACSN 10485906 10754326 10820262 10952726 11134049 11399519 11489965 11579131 11777960 11830590 11870632 11875494 11964313 12193701 12223527 12413632 12433365 12796776 12811837 12818165 12907458 12967644 14607900 14607933 14660645 14764699 15465827 15634932 15644117 15699106 15778339 15811952 15814715 16127449 16286920 16424049 16713974 16878026 17016554 17260466 17404308 17485448 17513775 17559085 17689680 1825141 18272812 18345002 19833085 19879327 20038811 20819927 21097505 21149606 21263073 21411734 21930765 23390297 24658051 25960930 26755705 2965306 6357187 6425450 7594497 8683106 8871614 9834059 9864217
PTPN11 IFNG â—¼   DOWN_REGULATES ✅ - 34.0 1.0 ACSN 10358138 11447289 11449354 11572860 12138178 12176909 1238444 12393695 12421919 12707331 12773515 12917349 15169881 15240681 15699106 15713798 16204085 19833085 20363967 20435894 21469115 22483603 22513334 22683124 22952938 22955274 25355530 26667266 26755705 27474009 8976179 8986721 9751747 9765283
IFNG STAT1 â—¼   DOWN_REGULATES ✅ - 69.0 1.0 ACSN 10485906 10754326 10820262 10952726 11134049 11399519 11489965 11579131 11777960 11830590 11870632 11875494 11964313 12193701 12223527 12413632 12433365 12796776 12811837 12818165 12907458 12967644 14607900 14607933 14660645 14764699 15465827 15634932 15644117 15699106 15778339 15811952 15814715 16127449 16286920 16424049 16713974 16878026 17016554 17260466 17404308 17485448 17513775 17559085 17689680 1825141 18272812 18345002 19833085 19879327 20038811 20819927 21097505 21149606 21263073 21411734 21930765 23390297 24658051 25960930 26755705 2965306 6357187 6425450 7594497 8683106 8871614 9834059 9864217
IRF2 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12479817 18281489 10859338 10454342
STAT1 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 70.0 1.0 Omnipath 12759422 14735146 26170288 8823363 1833631 8647290 7619083 11416037 12130529 16162660 21178011 9218597 12493643 17283162 15217838 10830295 24200694 7957928 19476491 9271410 19262492 7565811 9880553 17878383 9748323 21039465 17016440 10881178 21530491 17270146 12052885 15055356 10201928 18616672 13678429 19124156 9491997 24478085 8509377 8990168 12893768 16380218 23740952 17105733 16195385 23419754 19935876 7796811 17558024 19929594 10713330 23645984 9548487 11390994 12223098 15931263 17689680 18802113 18787082 10440232 20004484 10373559 10585866 10707961 12403783 23582260 10982806 9059994 16785492 22767256
IFNG STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 29796172 23285134 18566411 28430601 28143527 24366643 24608040 17947699 25950470 19846878 27378243 18950705 27570112 15051500 17986321 26467650 23657944 20087684 9649436 22823229 14517275 22178447 22425562 23352233 23562842 28445952 11960596 17997851 24443556 26934444 24777831 11972023 12725866 26113305 22162832 29925830 10707961 23840250 25753288 9454765
TRAF2 IKBKB â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 11274345 12847084 15592525 17462996 18641653 19392652 19509052 21133840 21232017 23430059 23850759 24378531 26587781
IKBKB MAP3K1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 9008162 19666475 9689078 12221085
TRAF2 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 27387502 15725726 12547194 11359906 25241761 20449947 16713569 18362886 23007157 10795740 21119000 19150425
MAP3K1 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17145710 9819420 9008162 16286467 9689078 16285893 9520401
TBK1 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 10783893 21903422 21138416 10195894 14743216 16207722 10022904 14560022
IKBKG IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 150.0 1.0 Omnipath 17145710 16938294 20932476 35339487 18266324 16260493 27929056 25979343 19666608 26496610 12133833 12192055 9751060 21423167 19706536 15836773 17561400 22099304 23986494 19959994 15327770 25400026 24266532 18450452 12657630 20434986 11583588 20200955 20300203 21903422 22990857 14743216 20167598 20098747 16126728 19656241 25852190 16906147 10195894 17000764 18329793 16186825 16547522 16611882 18037881 10968790 16497931 25286246 18462684 18207244 16603398 17965022 17977820 24240172 17568778 15084594 16129692 23506214 16319058 23123196 18949366 15218526 22605335 20368414 10837071 19820708 10980203 23131831 17363973 15214841 25304104 16493424 15184390 15691841 11864612 15802604 17693255 21455180 11865184 20211142 11971985 16970925 24469399 24618592 12486103 11057907 24369075 19365808 18583959 27426725 12612076 19422324 10094049 23109003 21803029 12459277 21640763 16285893 18266467 12709429 15620648 17072322 19815509 15749833
SRC IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 17145710 12645577 12707358 15456896
TRAF6 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 16260493 15691841 15620648 15327770 10195894 16186825 16493424 17965022 10094049 10837071
MAVS IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17145710 16177806 16153868 21903422 17468758 18207245
TRAF3 IKBKE â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 12692549 15210742 16306936 16281057 14530355 17526488 17047224 14703513 23453971
TRAF3 IKBKE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 16177806 15210742 15210743 16306936 16127453 17468758 12702806 17327220 16858409 24763515
TBK1 IKBKE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17599067 16177806 15210742 15210743 16306936 16127453 17468758 12702806 18353649 17327220 16858409
MAVS IKBKE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 17145710 15210743 16127453 19153231 17020950 25636800 15210742 16306936 12702806 16177806 27419230 36056146 19546225 19380491 16858409 21200404 24706939 18207245 17468758 17327220
IKBKE TBK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17599067 16177806 15210742 15210743 16306936 16127453 17468758 12702806 17327220 24622840 16858409
IKBKE STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 24065129 17502367 24416652 29186193 24058806 22520844
IKBKE TANK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 17823124 21212807 21138416 21931555 12133833 17568778 25852190 23007157 10759890
IKBKE IRF7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 16625202 25225665 9786932 15210742 22787218 10893229 26712804 16127453 12702806 16380379 15367631 12692549 17706453 16199137 16914100
TRAF6 IKBKG â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 18180283 18347055 21220427 16547522
RNF31 IKBKG â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 11280761 11460167 14660645 17301840 18264787 21133840 21232017 24699077 24958845
TRAF2 IKBKG â—¼   ENZYMATIC_REACTION ✅ 84.0 1.0 ACSN 10542212 10754326 10820262 10925299 10952726 11112697 11274345 11280761 11438547 11460167 11875494 12133805 12433365 12646658 12811837 12907458 1431106 14607933 14625680 14660645 15099563 15199157 15465827 15485931 15536066 15592525 15644117 15699106 15749903 16243976 16413922 16713974 16818229 16878026 16970925 17237376 17254973 17301840 17363905 17404308 17462996 17485448 17693255 17916596 18264787 18345002 18633355 18641653 18716620 19392652 19411070 20038811 20138012 20184663 20300203 20435894 21133840 21217011 21232017 21411734 21807870 21826665 22435554 22955274 23086447 23170255 23390297 23422957 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 2649237 28462531 7594497 8910423 9743347
RIPK1 IKBKG â—¼   ENZYMATIC_REACTION ✅ 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
RBCK1 IKBKG â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 11280761 11460167 14660645 17301840 18264787 21133840 21232017 24699077 24958845
MAP3K1 IKBKG â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 9008162 19666475 9689078 12221085
TRAF2 IKBKG â—¼   DOWN_REGULATES ✅ - 84.0 1.0 ACSN 10542212 10754326 10820262 10925299 10952726 11112697 11274345 11280761 11438547 11460167 11875494 12133805 12433365 12646658 12811837 12907458 1431106 14607933 14625680 14660645 15099563 15199157 15465827 15485931 15536066 15592525 15644117 15699106 15749903 16243976 16413922 16713974 16818229 16878026 16970925 17237376 17254973 17301840 17363905 17404308 17462996 17485448 17693255 17916596 18264787 18345002 18633355 18641653 18716620 19392652 19411070 20038811 20138012 20184663 20300203 20435894 21133840 21217011 21232017 21411734 21807870 21826665 22435554 22955274 23086447 23170255 23390297 23422957 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 2649237 28462531 7594497 8910423 9743347
IKBKG STAT1 â—¼   DOWN_REGULATES ✅ - 38.0 1.0 ACSN 11280761 11438547 11460167 12133805 12811837 14660645 15145317 15199157 15485931 15536066 15573129 16818229 16970925 17237376 17254973 17301840 17363905 17485448 17693255 18264787 18716620 19833085 20138012 20300203 21133840 21217011 21232017 21807870 22435554 23086447 23422957 23430059 24378531 24699077 24766893 24958845 2649237 28462531
TRAF6 IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 17562858 17728323 17947236 14695475 18180283 15620648 15125833 12867425 11057907
RIPK1 IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 10880512 21383699 21458669 14653779 10980203 17702576 9927690 16603398 16547522 16965765 10755617
TANK IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 21988832 19854139 25861989 17468758 20484576 12133833 16189514 21419663
TRAF2 IRF1 â—¼   ENZYMATIC_REACTION ✅ 49.0 1.0 ACSN 10820262 10925299 11112697 11274345 11280761 11438547 11460167 11875494 12433365 12646658 12811837 1431106 14607933 14625680 14660645 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18345002 18633355 18641653 19392652 19411070 20038811 20184663 20435894 21133840 21232017 21411734 21826665 22955274 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 8910423
STAT1 IRF1 â—¼   ENZYMATIC_REACTION ✅ 46.0 1.0 ACSN 10485906 10754326 10820262 10952726 11134049 11399519 11830590 11875494 11964313 12193701 12223527 12433365 12796776 12811837 12907458 12967644 14607900 14607933 14660645 14764699 15465827 15644117 15699106 15814715 16127449 16878026 17016554 17260466 17404308 17485448 17513775 17559085 17689680 18272812 18345002 19833085 19879327 21097505 21263073 21930765 23390297 25960930 6357187 7594497 8683106 8871614
TP53 IRF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15509808 9806359 12732645 11350897
STAT1 IRF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 10528163 9218597 10068671 18694960 11752148 17270146 12077266 20825659 24478085 11694349 9307237 8621447 18401423 9806359 22002246 10764778 16140971 19122651 18497060 7678055 8647845 10666420 8168491 9259325 21200019 17558387
IRF1 IRF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 7630638 7507207 9054665 8152803 15560761 10321737 12493643 1431317
STAT1 IRF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 24012417 16512786 10764778 17918184
STAT1 IRF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22951020
TANK IRF7 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15210742 16281057 14703513 9566918 17157040
TRAF3 IRF7 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15210742 16281057 14703513 9566918 17157040
STAT1 IRF7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 22951020 11877397 16628196 22252317 12768031 15767254 15664995
TRAF6 IRF7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 22095711 18710948 21743479 30927622 15361868
TBK1 IRF7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 16625202 17599067 9786932 15210742 22787218 26712804 16127453 12702806 15367631 12692549 16380379 17706453 16199137 16914100
UBE2L6 ISG15 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11157743 15485925 18583345 15131269
ITCH RIPK1 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 10940313 11318614 16469705 16861923 18552861 18628966 19131965 20068034 21107885 21383157
PCBP2 ITCH â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19881509
ITCH MAVS â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 19881509 27736772
KDM1A TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 17805299 26334721 19381457
MAP1LC3B SQSTM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 18083104 23022382 35044719 26413874 25416956 22434781 31053714 24023838 19250911 17580304 23333919 20452972 24668264 28085563 21900206 20562859 20010802 25007327 32296183 33302793 24582747 33436498 16169070
RIPK1 MAP3K1 â—¼   PHYSICAL_INTERACTION 27.0 1.0 ACSN 10465784 11274345 11668179 12048245 12738796 14730360 15170913 15592525 17462996 17496911 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26587781 26653790 28574505 28765050 9379049 9582321
TRAF2 MAP3K1 â—¼   PHYSICAL_INTERACTION 27.0 1.0 ACSN 10465784 11274345 11668179 12048245 12738796 14730360 15170913 15592525 17462996 17496911 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26587781 26653790 28574505 28765050 9379049 9582321
RIPK1 MAP3K1 â—¼   SHARES_COMPLEX 27.0 1.0 ACSN 10465784 11274345 11668179 12048245 12738796 14730360 15170913 15592525 17462996 17496911 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26587781 26653790 28574505 28765050 9379049 9582321
TRAF2 MAP3K1 â—¼   SHARES_COMPLEX 27.0 1.0 ACSN 10465784 11274345 11668179 12048245 12738796 14730360 15170913 15592525 17462996 17496911 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26587781 26653790 28574505 28765050 9379049 9582321
RIPK1 MAP3K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11369754
MAP4K1 MAP3K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8824585 23331499 9003777
TRAF2 MAP3K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 10346818 17145710 25241761 16636664 10755617 18635759 25260751
MAVS TRAF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 22901541 19893624 17020950 18818105 21200404 16306936 18207245 19546225 22844514 22792062 19193783 34610835 16858409
MAVS TBK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 21813773 15210743 16127453 33372174 17020950 25636800 21903422 15210742 16753195 16306936 12702806 24643253 16177806 27419230 16153868 16858409 29743353 17468758 17327220
OTUD5 TRAF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 17991829
PPP1CA TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 16501611 16713569 15231748 15178317
PPP1CC TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 17145710 17274640 15178317 16501611
PRKCA TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 18812399 9935181 15659650 9315650 19933256 16713569 9571186 1454855
PRKCA SDC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 9556568 11916978 14670076 12571249 12377772
PRKCA PTPN11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16055440 11781100
PRKCA SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 17496910 11940581 21386996 10527887 2996780 11447289 19615955 16488589 6321473 8321321 12845332 11313945 2136766 17570479 12040186 19568798 15567848 14585353
PRKCB SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 17496910 11940581 21386996 11447289 19615955 16488589 6321473 8321321 12845332 11313945 12040186 19568798 15567848 14585353
PRKCG SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 17496910 11940581 21386996 11447289 19615955 16488589 6321473 8321321 12845332 11313945 12040186 19568798 15567848 14585353
PTPN11 STAT1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 10358138 11447289 11572860 12138178 12270932 12707331 15240681 15699106 15713798 19833085 9751747
PTPN11 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 18757826 18482983 10698938 17974954 14687660 24632723 20308328
PTPN11 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 18508557 12270932 18832710 18988627
RBCK1 RNF31 â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 11280761 11460167 14660645 17301840 18264787 21133840 21232017 24699077 24958845
RBCK1 RNF31 â—¼   SHARES_COMPLEX 9.0 1.0 ACSN 11280761 11460167 14660645 17301840 18264787 21133840 21232017 24699077 24958845
TRAF2 RIPK1 â—¼   PHYSICAL_INTERACTION 92.0 1.0 ACSN 10465784 10734135 10925299 11003656 11112697 11274345 11280761 1134007 11438547 11460167 11583996 11668179 11875494 12048245 12215447 12556535 12646658 12655147 12702723 12724420 12738796 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15170913 15310755 15592525 15699106 15760909 16406523 16498403 16713974 16940415 17301840 17462996 17496911 17916596 18264787 18292600 18633355 18641653 18855897 19392652 19411070 19524513 19597341 19632174 19838173 20038811 20184663 20435894 20452955 20531300 21133840 21232017 21411734 21614932 21826665 22427918 22955274 23010170 23069999 23070005 23170255 23377657 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 27984721 28574505 28765050 8910423 8974401 9379049 9488730 9582321 9759866
TRAF2 RIPK1 â—¼   SHARES_COMPLEX 92.0 1.0 ACSN 10465784 10734135 10925299 11003656 11112697 11274345 11280761 1134007 11438547 11460167 11583996 11668179 11875494 12048245 12215447 12556535 12646658 12655147 12702723 12724420 12738796 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15170913 15310755 15592525 15699106 15760909 16406523 16498403 16713974 16940415 17301840 17462996 17496911 17916596 18264787 18292600 18633355 18641653 18855897 19392652 19411070 19524513 19597341 19632174 19838173 20038811 20184663 20435894 20452955 20531300 21133840 21232017 21411734 21614932 21826665 22427918 22955274 23010170 23069999 23070005 23170255 23377657 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 27984721 28574505 28765050 8910423 8974401 9379049 9488730 9582321 9759866
STAT1 RIPK1 â—¼   ENZYMATIC_REACTION ✅ 46.0 1.0 ACSN 10485906 10754326 10820262 10952726 11134049 11399519 11830590 11875494 11964313 12193701 12223527 12433365 12796776 12811837 12907458 12967644 14607900 14607933 14660645 14764699 15465827 15644117 15699106 15814715 16127449 16878026 17016554 17260466 17404308 17485448 17513775 17559085 17689680 18272812 18345002 19833085 19879327 21097505 21263073 21930765 23390297 25960930 6357187 7594497 8683106 8871614
SQSTM1 RIPK1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 12702723 15340068 16252010 16498403 20531300 21981924 23069999 25002027 26587781 28574505 9184224
TRAF2 RIPK1 â—¼   ENZYMATIC_REACTION ✅ 92.0 1.0 ACSN 10465784 10734135 10925299 11003656 11112697 11274345 11280761 1134007 11438547 11460167 11583996 11668179 11875494 12048245 12215447 12556535 12646658 12655147 12702723 12724420 12738796 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15170913 15310755 15592525 15699106 15760909 16406523 16498403 16713974 16940415 17301840 17462996 17496911 17916596 18264787 18292600 18633355 18641653 18855897 19392652 19411070 19524513 19597341 19632174 19838173 20038811 20184663 20435894 20452955 20531300 21133840 21232017 21411734 21614932 21826665 22427918 22955274 23010170 23069999 23070005 23170255 23377657 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 27984721 28574505 28765050 8910423 8974401 9379049 9488730 9582321 9759866
TRAF2 RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 45.0 1.0 Omnipath 8702708 8612133 25416956 16713569 18621737 25882049 16291755 18981220 21741934 21232017 20577214 11181075 10795740 23972990 21119000 15175328 20203691 21810480 21282461 9712898 32296183 23007157 25716317 20448643 12887920 24735611 15258597 24434549 19815541 16603398 11479302 9020361
SQSTM1 RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 26416459 10356400 19850933
TRIM25 RNF135 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 19017631 20403326 24755855 19484123 17392790
RNF135 TRIM4 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 19017631 20403326 24755855 19484123 17392790
TRAF6 SQSTM1 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 11274345 12620219 14660645 15125833 15340068 15721744 16252010 17948050 18264787 18758450 18922473 19161412 20531300 21981924 25002027 26587781 28574505
TRAF6 SQSTM1 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 11274345 12620219 14660645 15125833 15340068 15721744 16252010 17948050 18264787 18758450 18922473 19161412 20531300 21981924 25002027 26587781 28574505
TBK1 SQSTM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 24818040 25040165 29147513 28655770 31810986 28871090 25505069 32966780 27846364 31444413 27404485 34996837 32835772 24886973 30223576 29930914 29973599 27005665 22921120 25723488 25972374 33084718
SQSTM1 TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 15870274 27458013 10747026 27681126 16079148 16189514 18382763 16874300 11244088 17389358
SRC STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 11839738 10918587 9344858 7543024 15322115 10358079 14978237 11294897 7690989 16189514 12637327 11438544 10748192 7657660 12817007 9355737 11152457 10982844 7592750
STAT1 ZC3HAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22951020
STAT1 TRIM25 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17069755
TANK TBK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 16127453 17568778 27035970 25409927 23286385 18307994 24488098 21419663 21988832 21903422 15210742 14743216 16189514 19820708 21931555 10581243 23007157 17823124 17468758 17327220
TANK TRAF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 20562859 21988832 21903422 8710854 12005438 14743216 10581243 16713569 23007157 10759890
TRAF3 TBK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 27135603 15210743 16127453 15210742 16306936 12702806 23986588 22792062 16177806 20389019 17991829 20174559 16858409 23717208 34084167 22330071 17468758 17327220 24622840
UBE2D1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15169778 15340381 15147722 12820959 10722742 19459846 18006823 10721693 19440234
TP53 UBB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 18172499 18695251 24667498 22056774 17290220 17592138 12421820 18413597 20173098 19556538 21857681 17470788 18359851 19805293 19196987 12640129
TRIM25 TRIM4 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 19017631 20403326 24755855 19484123 17392790
UBE2L6 UBA7 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11157743 15485925 18583345 15131269