Protein list:

Seperate proteins by space | Example

Select nodes using shift click or drag to add to this list
Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

Note this may take some time with > 30 proteins
Filter Graph:

0.5
Layout:
  🔂

Click a node or edge for more data...
Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
AP1M1 ENTR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8153045 21516116
HBB HBA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
HBA1 HBA2 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
HBB HBA2 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
EPOR CRKL â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11443118 11124936
STAT3 ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21677772 23911788
IRF8 BCL2L1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10430629 23677993
STAT3 BCL2L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11994401
TP53BP1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15970701 21914189
ESR1 CCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20404154 17932106
FLI1 CCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25108845 23108091
STAT5A CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15003515 21038417
ETV6 CR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10597047 12220513
SUMO2 CTBP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20176810 20098713
SUMO1 CTBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12769861 12679040
EPOR SOS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9209406 8400282
EPOR PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11598010 12506011
STAT5A EPOR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10882725 11013351
ESR1 MMP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22927007 24374826
ESR1 HBB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14695898 18252963
ESR1 MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23250869 22430216
ESR1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 3677090
ESR1 NFE2L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 24641954 20623181
STAT3 ETV6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15229229
ETV6 FLI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17606295 19829305
ETV6 MMP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11439334 10913166
GRB2 GAB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5212828 10913131
MAPK3 GAB2 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5217186 15356145
PIK3CA GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
GRB2 SPTBN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 LMNA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
MAPK3 GRB2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7739560 8816480
MAPK1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8994038
HDAC3 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22002311 18483244
NUP98 HNRNPUL1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19745842 7293793
STAT5A IL10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18768844 23797738
IL3 SOS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 1465135 8294403
RUNX1 IL3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9036972
IRF8 PTPN13 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22262849 18195016
UBE2I KAT5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
SUMO2 KAT5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22661230 22635276
SUMO1 KAT5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
KAT5 LMNA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
LRP6 PDGFRB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21245321 1019443108
MAPK3 SOS1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7739560 8816480
SUMO1 MDC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
UBE2I MDC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
STAT3 MMP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23967200 17460772
RUNX1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 29958106
MYC PDGFRB â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15226411 18697203
MYC PIK3R1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19602047 11509615
STAT3 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22943793 15810077
NFE2L2 PIK3R1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23708697 24180671
NUP88 NUP214 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
PDGFRB STAT3 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 17145802 17496910
PDGFRB PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 8702949
PDGFRB STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 9484840
PIK3R1 SOS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PIK3R1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25814554 15021914
PIN1 SOCS3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
STAT3 PTPN13 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24191246 15870198
SIN3A SUMO1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17036045 5219211
USP7 SKP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19680264
STAT5A SOCS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23716134 24018353
SOCS3 STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 11331873
SUMO1 TP53BP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20016603 25114211
SUMO2 TP53BP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22661230 22635276
UBE2I TP53BP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22661230 22635276
MDC1 LMNA â—¼   KO_UP_REGULATES ✅ + 0.8 0.8 PKG 28854368
SUMO2 MDC1 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 32786267 19471022 22661230 19394292
LIMD1 EGLN3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26972000 22286099
CRKL SOCS1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25814554 29991678
ESR1 CTBP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 23403292 31527615
MYC CTBP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 21150319 34147029
GRB2 CYLD â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
CYLD LMNA â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 29568061 27591049
SKP1 ESR1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31527615 23770852
ETV6 SIN3A â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 12527908 11439334
TBL1Y HDAC3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
MYC XPOT â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17314511 29467282
MYC RUNX1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 21150319 29467282
TBL1Y NCOR1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
SUMO1 SIN3A â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 24654937 17036045
SUMO1 ZMYM2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17027752 16524884
GRB2 PDGFRB â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
TRIP6 LIMD1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
ECH1 TRAF3 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
TRAF3 ETV6 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 22792062 35140242
SUMO2 ETV6 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 12626745 19471022 35140242 21693764
ETV6 NID2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
ETV6 LRP5 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
ETV6 LRP6 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 35140242 26186194
KAT5 STAT3 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 12551922 16713569
MYC LMNA â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 21150319 17314511 29467282
LMNA PIAS2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 29568061 24623722 34079125
KAT5 MYC â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
BRCA1 UBC9 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 19287951 20016594
UBC9 TRAF3 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 24260396 32296183
ESR1 SUMO1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 15961505 31527615
NCOR1 ETV6 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 11001911 11439334
LMNA MDC1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 30179224 30419336 22412018
HDAC3 STAT3 â—¼   PHYSICAL_INTERACTION 845.0 0.84 STRING 36370105
LMNA UBC9 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 19596686 16248985
SUMO2 BRCA1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 21147198 20016594 20016603 22689573 21693764
PIN1 ETV6 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 33961781 32296183 16055720
MYC HDAC3 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 18483244 31155734 22002311 23079660
SUMO2 ZMYM2 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
HDAC3 ESR1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 16469706 26487511 14722073 31527615 20348541
ESR1 STAT3 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 23874500 11429412
PIK3R1 GRB2 â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 5220480 7642581
HBA2 HBB â—¼   PHYSICAL_INTERACTION 0.86 0.86 HuRI 32296183
NUP62 NUP54 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 27194810 32296183 25416956 8045926 21516116 28514442 16189514
UBC9 PIAS2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 11867732 32296183 14609633 19549727 20936779 12177000 21988832 16713569 25409927 25416956 16189514 16148010
NTAQ1 CEP85 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 32296183
HDAC6 CYLD â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 20593489 19893491
ETV7 ETV6 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 35140242 26186194
SOCS1 GRB2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 10022833 29991678
NUP62 TRAF3 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 10781837 33961781
NUP62 NUP88 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
BRCA1 MYC â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
CDKN1A STAT3 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
BRCA1 MDC1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
BRCA1 TP53BP1 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
CRKL PIK3R1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
CTBP1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11751867 10196224 16713569 21102443 31636387
SOCS3 EPOR â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 10882725 12027890
SUMO1 ETV6 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 24654937 12626745 26871637 11078523
SIN3A HDAC9 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 12590135 11959865
MAPK1 MAPK3 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
MAPK1 STAT3 â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
GAB2 CRKL â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 9660791 10871282 11334882
ETV6 UBC9 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 25416956 16713569 10377438
MDC1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 21622030 17525332 15569676 29656893 12607005 19766185 12611903
BRCA1 SUMO1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 26831064 18025037 20016594
HDAC9 CTBP1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 20361981 16713569 11022042
EPOR GRB2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 9129019 7534299 8647802 16713569
PIAS2 MYC â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 17418410 16352593 18923429 17471507 11283613 30415952 20426839 19786833
MYC SKP1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 12963825 29467282 30415952 21988832 17314511
NUP88 NUP62 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 28514442 32296183 26344197
NUP62 PIN1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
SUMO2 PIAS2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 22578841 19394292 32786267 16524884 21252943 19217413 21693764
FLOT1 FLOT2 â—¼   CORRELATES + 0.89 0.89 CCLE 31978347
GAB2 PIK3R1 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
BBC3 BCL2L1 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
ETV6 PIN1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
PDGFRB CRKL â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10508235 9546424 9739761
ARHGAP32 CRKL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12446789 23331499
MYC FPGS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
STAT5B BCL2L1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20585448 11756417 22729867
MYC BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11916966 9788437 20215511 30415952 16713569 12646176 14612409
ESR1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11493692 27977889 10334989 11782371 16713569 17505062 15674350 19887647 20060929 11244506 16860316 17392432 31527615 16061635 16260778 12400015 1244506 25499220 29367421
BRCA1 ESR1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
BRCA1 NFE2L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15520196
ESR1 CCL7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20034404
RUNX1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10617663 23487742 23150456
KAT5 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17671089 20351180 16601686
SKP1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16376880 25241761
RUNX1 CR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10597047 10533284 12220513
UBE2I CTBP1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 20176810 20098713 12679040
SUMO1 CTBP1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 20176810 20098713 12679040
EPOR STAT5B â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9837784 22509308 8861946
SOCS3 EPOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10882725 12027890
EPOR GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8647802 16713569 7534299
NCOR1 ESR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 16469706 17400812 12145334 16713569 12738788 21182203 24051437
STAT5B ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11731618 11682625
STAT3 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21546410
ESR1 SUMO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15961505 24119295 18404132
ESR1 NID2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20034404
ESR1 INHBA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17951260 19763504 18414489
ESR1 SPATA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20034404
ESR1 FOXC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25303530 18414489
ESR1 SOCS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16055089 18414489
PIK3CA GAB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11002419 10995764 10448070
ITGA2B GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12005431 9566877 7997267
MYC HDAC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
HDAC9 NCOR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 12590135 16713569 11466315
STAT3 IL19 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 20966397 11564763 18669613
MYC LMNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
STAT5A MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17927978 12048235 12967477
MYC ZNF146 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
NUP88 NUP98 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 28514442 22480613 12589057
PDGFRB SOS1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7935391 8388543 9739761
PDGFRB PIK3CA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 2466336 1374684 9739761
PIK3CA SOS1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 21653832 16456001 10068651
SOCS3 SOCS1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 17363902 14512302 9885206
STAT5B SOCS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10821852 16306356 10359822
STAT5B STAT5A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15043997 17997837 14532269
STAT5A STAT5B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21542777 15043997 17997837
MDC1 BCL2L1 â—¼   KO_UP_REGULATES ✅ + 0.9 0.9 PKG 28854368
FLOT1 FLOT2 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
GRB2 SOS1 â—¼   RELOCALIZATION ✅ + 0.9 0.9 Signor 23452850
GRB2 PIK3R1 â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
PDGFRB PIK3R1 â—¼   PHYSICAL_INTERACTION 926.0 0.92 STRING 36370105
PIAS2 SUMO2 â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
NUP54 NUP98 â—¼   PHYSICAL_INTERACTION 940.0 0.94 STRING 36370105
NCOR1 SIN3A â—¼   PHYSICAL_INTERACTION 0.95 0.95 HIPPIE 17210713 16713569 11430826
PIK3R1 PDGFRB â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 7536927 6730373
UBE2I SUMO1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 5219915 17491593
MDC1 TP53BP1 â—¼   PHYSICAL_INTERACTION 951.0 0.95 STRING 36370105
CRKL EPOR â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 9344843 9129019 11443118
UBC9 SUMO2 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 33961781 25027693 26496610 23871147 24969970 20797634 26344197 30574775 16524884 17938407 16713569 31056421 21693764 19471022 30201799 32786267 12924945 28514442 16189514 21949651 17491593 16620772 22578841 11451954 28784659
SKP1 FBXL6 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 33961781 26344197 32576198 27705803 19159283
PIAS2 UBE2I â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
SEC13 SEC16A â—¼   PHYSICAL_INTERACTION 968.0 0.96 STRING 36370105
PIK3R1 PIK3CA â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 20018188 7383613
GAB2 GRB2 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
NUP214 NUP62 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
PIAS2 SUMO1 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
NUP214 NUP88 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
UBC9 SUMO1 â—¼   PHYSICAL_INTERACTION 0.99 0.99 HIPPIE 16494873 16732283 18359863 25502805 10961991 26496610 23871147 26264872 15931224 26344197 9497385 16524884 17938407 9920803 18691969 16713569 9353268 11735126 19684601 21518904 32296183 17353931 8921390 17956732 14673145 19785004 21212807 12924945 22411991 20501649 25416956 16189514 17491593 21949651 21174150 24352468 18264111 18211895
SUMO1 UBE2I â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
NUP54 NUP62 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
SUMO2 UBE2I â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
NUP98 SEC13 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
HBA1 HBB â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
GRB2 SOS1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PIK3CA PIK3R1 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
MYC HBA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 2463629 12695333
GRB2 CRKL â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
VEGFA CRKL â—¼   PHYSICAL_INTERACTION 34.0 1.0 ACSN 10022831 11166270 11960372 12629515 13678960 15099563 15111329 15308668 15501236 15520864 15573129 16000375 16002046 16076871 16530705 16572188 17086423 17883421 18835194 19414323 19454690 21372296 22064427 22461508 22464172 23390297 24217602 24346288 25922287 26201938 8837607 9157999 9570538 9753319
GRB2 CRKL â—¼   SHARES_COMPLEX 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
VEGFA CRKL â—¼   SHARES_COMPLEX 34.0 1.0 ACSN 10022831 11166270 11960372 12629515 13678960 15099563 15111329 15308668 15501236 15520864 15573129 16000375 16002046 16076871 16530705 16572188 17086423 17883421 18835194 19414323 19454690 21372296 22064427 22461508 22464172 23390297 24217602 24346288 25922287 26201938 8837607 9157999 9570538 9753319
CRKL PIK3R1 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
CRKL PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9092574 16135792 11418612 23397142 9461587 16982329
GAB2 ARHGAP32 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 12819203
MYC BBC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12695333 12384701 19815507 20145032 21835778
BBC3 BCL2L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17145710 16697956 15694340 19074266 28202514 15574335
MYC BCL2L1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 14517295 18802399 16316993 17331788
STAT3 BCL2L1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 15805299 20067773 15184887 15469392 16651438 11369651 16912181 17880940 16384639 21344490 20069389 18222423 21172343 21184768 21435102 18544087 18790750 20654581 11850821
STAT5A BCL2L1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 10979976 10428780 20585448 10727459 12946994 10435632 11731240 10428030 10964754 15545372 19339209 11756417 16214938 15626738
STAT5A BCL2L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10428780 19211554 10652277 11085453 10435632 10428030 11756417
STAT5B BCL2L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10428780 19211554 10435632 10428030 11756417
TP53BP1 BRCA1 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11042216 11877378 17243194 18087291 19342239 20646866 9748285
MDC1 BRCA1 â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 12607003 15279786 15459660 17303408 17660363 18001824 18006705 18087291 18583988 18590585 18678890 7575488 9407949
MYC BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12032322 19882681 20940401 10375022 21668996 11916966 12646176 11983916
CTBP1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20818429 21681822 23303449
BRCA1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9926942 11394910 10196224 18025037 21245169 16735508 12647291
MDC1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 18087291 17525332 12607005
BRCA1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11244506 12400015 15674350 10334989 16713569 11493692
STAT3 CCL2 â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
STAT3 CCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 24429361 19741199 17710228 19736311 12488502 20493732 19404962
HDAC3 CCL7 â—¼   DOWN_REGULATES ✅ - 11.0 1.0 ACSN 11399519 11875494 15644117 16127449 17260466 17681149 17689680 21234400 23390297 6357187 8871614
NCOR1 CCL7 â—¼   DOWN_REGULATES ✅ - 11.0 1.0 ACSN 11399519 11875494 15644117 16127449 17260466 17681149 17689680 21234400 23390297 6357187 8871614
NCOR1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 22253232 20466759 20696891 24821728 24821727
STAT3 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23178160 19372587 15286705 18320073 15063116 16923815 9694869 22328012 12438313 11773079 20654581 10023678 19329556 21184768 11114718
ESR1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 15557281 16628468 20696891 16847062 12151347 11517191 15378598 11274368 16469747 17681750 20301197 22787161 23349794
MYC CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 41.0 1.0 Omnipath 15190211 14519204 15616584 12408868 19174556 21949397 10319992 12553001 16204065 12545156 20878079 21042278 21400515 20190815 16706751 23804320 15757889 10920185 19270520 16452181 12408820 15528212 22371483 12565816 17885207 12384701 11274368 19150257 20551174 15899785 21120446 15071503 15474507 22814619 12835716 12748190 16738884 15711923 18636159
HDAC3 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9618481 17550342 12545156 15155580 22796940 22370643 16533812 17508028
MYC CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 15528212 9618481 12545156 17550342 10454538 15155580 11283613 10920185 11283614
MAPK1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 20519948 19364816 28368408
CDKN1A STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 25241761 16189514 10764767
EPOR STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8977232 15644415 10374881 27752093
EPOR PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 7559499 15644415 16713569 24113870 9162069
STAT5A ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11731618 22201800 11682624 11682625
ESR1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 22396492 21835891 15073177 18193094 11517191 21505052 22892083 8707895 19569049 14722073 18414489
ESR1 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 16267616 12400015 17272396 18252963 18497067 10866309 19420388 19398483 16249470 14647449 15774498 12208749 10995484
MAPK3 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 10949034 18372406 15461668 9528769 12118371 14680484 17615152 15059947 16076840 7491495 12093745 15212693 15528270 7838153
NCOR1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 16469706 12738788 12145334 17400812 16713569 21182203
MAPK1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 15655247 10949034 15528270 18372406 15461668 12118371 12466266 7495695 17615152 15059947 16076840 7491495 12093745 10409727 9528769 7838153
ESR1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11029009 11689445 16169518 23065768 16713569
PIK3R1 ETV6 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 19345670 9918857 19438505 23168613 27795560 31066629 17764812 11027663
ETV6 STAT5A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 31066629 17764812 19345670 23168613
ETV6 SOS1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 19345670 23168613 27795560 31066629 17764812
ETV6 GOLGB1 â—¼   PHYSICAL_INTERACTION 13.0 1.0 Reactome 29025582 28028030 24854988 28751768 19345670 17268528 23168613 27795560 30559310 31066629 17764812 16761019 21705501
ETV6 STAT5B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 31066629 17764812 19345670 23168613
ETV6 SPTBN1 â—¼   PHYSICAL_INTERACTION 13.0 1.0 Reactome 29025582 28028030 24854988 28751768 19345670 17268528 23168613 27795560 30559310 31066629 17764812 16761019 21705501
ETV6 PIK3CA â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 19345670 9918857 19438505 23168613 27795560 31066629 17764812 11027663
MAPK3 ETV6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 12435397 15060146 18022807
FLI1 ITGA2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12356738 15466856 10194443 15232614
STAT5A GAB2 â—¼   PHYSICAL_INTERACTION 14.0 1.0 Reactome 16627759 22411868 11090077 26515730 20111072 15498859 10698507 12468433 12796379 30552988 23103841 31066629 15003515 17356133
STAT5B GAB2 â—¼   PHYSICAL_INTERACTION 14.0 1.0 Reactome 16627759 22411868 11090077 26515730 20111072 15498859 10698507 12468433 12796379 30552988 23103841 31066629 15003515 17356133
GRB2 GAB2 â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 10086337 10358164 10567412 10811803 10849428 10982827 11447289 11449354 11777939 12175651 12393695 12640133 15567848 15574420 16076871 16212621 16582911 16887996 17496910 17673906 19449109 19909365 26552706 8551221 9763606
MAPK3 GAB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 12008033 15356145
GRB2 GAB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 17145710 16371368 25416956 21706016 15143164 10391903 19172738 10913131 11027663 9973481 10973965 20936779 10068651 11882361 32296183 16199887 24737791 15010462 19523899 16253990 19380743 31515488 11782427
MAPK1 GAB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 12008033 15356145
GAB2 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 17145710 18950707 11334882 10068651 10982827 16253990 9973481 10871282 16135792 16219545 10973965 11782427 9885561 14530346
STAT5B GOLGB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 31066629 17764812 19345670 23168613
PIK3CA GOLGB1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 19345670 9918857 19438505 23168613 27795560 31066629 17764812 11027663
SOS1 GOLGB1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 19345670 23168613 27795560 31066629 17764812
PIK3R1 GOLGB1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 19345670 9918857 19438505 23168613 27795560 31066629 17764812 11027663
STAT5A GOLGB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 31066629 17764812 19345670 23168613
SPTBN1 GOLGB1 â—¼   PHYSICAL_INTERACTION 13.0 1.0 Reactome 29025582 28028030 24854988 28751768 19345670 17268528 23168613 27795560 30559310 31066629 17764812 16761019 21705501
STAT5B GRB2 â—¼   PHYSICAL_INTERACTION 14.0 1.0 Reactome 16627759 22411868 11090077 26515730 20111072 15498859 10698507 12468433 12796379 30552988 23103841 31066629 15003515 17356133
SOS1 GRB2 â—¼   PHYSICAL_INTERACTION 1.0 1.0 HIPPIE 8810325 33961781 8695800 7510700 8626525 34407391 16520382 10570290 16906159 16893902 7642581 8816480 9447984 12577067 11964172 8112292 8493579 7664271 16713569 7516467 19380743 9009162 10207103 17474147 10477741 32062451 7629138 21706016 20473329 19323566 9872323 32203420 7514169 21988832 28166272 28514442 9716598 11997436 9344843 15192046 10716926 8479541 14679214 8943292 31980649 7629168 7559490 9478994 7527391 8188688 11960376 10025673 11726515 7773779 10319320 9569023 9797459
STAT5A GRB2 â—¼   PHYSICAL_INTERACTION 14.0 1.0 Reactome 16627759 22411868 11090077 26515730 20111072 15498859 10698507 12468433 12796379 30552988 23103841 31066629 15003515 17356133
GRB2 VEGFA â—¼   PHYSICAL_INTERACTION 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
GRB2 VEGFA â—¼   SHARES_COMPLEX 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
GRB2 PIK3R1 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
GRB2 VEGFA â—¼   ENZYMATIC_REACTION ✅ 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
PDGFRB GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 7935391 16713569 7486683
GRB2 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 145.0 1.0 Omnipath 9544989 9872323 7642581 15746962 11726515 8621483 23334917 16520382 11997436 21706016 10359574 8950973 7664271 16713569 16893902 16906159 21988832 19323566 9009162 10716926 11964172 7629168 9815779 10592173 9716598 8647802 28166272 7773778 7773779 18778683 8188688 10319320 8810325 9344843 23452850 11960376 8816480 10025673 7510700 8940013 12955078 9697839 12345678 10477741 8493579 8943292 12577067 7862167 9199344 8112292 7898932 10207103 8695800 19531499 10570290 7760801 20005866 19380743 9447984 8235613 8479540 7527391 14679214 8479541 17474147 7514169 7629138
MYC HBB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 1904416 12695333 24725430
HDAC3 SIN3A â—¼   PHYSICAL_INTERACTION 27.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC3 NCOR1 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 11399519 11875494 15644117 16127449 17260466 17681149 17689680 21234400 23390297 6357187 8871614
HDAC3 SIN3A â—¼   SHARES_COMPLEX 27.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC3 NCOR1 â—¼   SHARES_COMPLEX 11.0 1.0 ACSN 11399519 11875494 15644117 16127449 17260466 17681149 17689680 21234400 23390297 6357187 8871614
HDAC3 SIN3A â—¼   UP_REGULATES ✅ + 27.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
NCOR1 HDAC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 11509652 11013263 16195251 11931768 16469706 21258344 17694085 10860984 16917504 10944117 23752268 16713569 14527417 11466315 11804585 12628926 15601853
MAPK3 HDAC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 24089523
TRAF3 IL10 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 15749884 16306937 16713974 17404308 20547845
IL10 STAT3 â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 10433356 10542212 10623821 11207245 11875494 12818165 14607900 14610620 15282297 15579430 16200688 16424049 16713974 17404308 19833085 20184663 21115385 21191065 21220452 21840487 26755705 7512720 7521688 7543512 9834059
STAT3 IL10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 21398617 18403020 10903771 25108026 24315995 21157434 12857749 28011648 31886314 18765795 19124156 18848473 12817009 16606674 21385272 21041726 28713870 22378047 15034082 17404037 15972681
IL10 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 24513872 20681025 29682323 25512602 19890111 25762897
IRF8 IL12B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 12393459 12417340 12876285 15837792 18055870 19487420 10861061 19893639
RUNX1 IL3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11997340 9036972 20506188 15735013 10023677 8180380
STAT5A IL3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15358227 14627821 24367002 10064602 12574125
IRF8 MYC â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10734131 11672593 11875494 11964313 12032143 12417340 12811837 16243976 16413922 16597464 17404308 17485448 22461508 23390297 24091328
STAT3 IRF8 â—¼   DOWN_REGULATES ✅ - 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
KAT5 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 12551922 16713569
KAT5 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12776177 19150978 15572685 34650217
MAPK3 LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17496910 18039929 19541618 21965663 20974802 19565474 15547943 12063245 12738796 11226259
MAPK1 LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17496910 18039929 19541618 21965663 20974802 19565474 15547943 12063245 12738796 11226259
MAPK1 SKP1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 31434245 22955283 12748172 16009132
MYC MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22789855 21933022 16596619 23617883 8013639 20144848
NFE2L2 MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19454702 23708697 17467702 21808062
MAPK1 STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 9804779 25241761 18775330 10194762 8226933 10996427 9604935 8388392 12091337
MAPK1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 10551811 17081983 8386367 17251036 91332050 17570479 1748630 7957875 27167001 15212693 1651323 15210690
MAPK1 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12975377 23602568 16424009 19058874 23397142 21707490
MAPK1 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23331499 10197981 8816480 9922370 8626428
MAPK1 RUNX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16046550 17015473
MAPK1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 59.0 1.0 Omnipath 18448488 19413330 11335711 9343414 15465816 25584415 12576423 11350938 20068231 12681450 12763138 9872331 11780390 18491316 18669648 11404481 10521505 18691976 20058876 15979846 14551213 10446219
MAPK3 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 18463697 9155018 21071413 32482868 18988627 15210690
MAPK3 STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 9804779 20508164 23331499 24263804 18775330 10194762 12407017 8226933 17502367 34188118 9604935 18988627 31932645 8388392 12091337
MAPK3 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 29145629 7478566 23331499 8816480 7739560 17570479 9922370
MAPK3 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 73.0 1.0 Omnipath 18448488 19413330 11335711 9343414 23331499 15465816 25584415 12576423 11350938 20068231 12681450 10417333 12763138 9872331 18988627 11780390 18491316 18669648 11404481 10521505 18691976 19723038 20058876 14551213 10446219
MDC1 TP53BP1 â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 12607003 15279786 15459660 17303408 17660363 18001824 18006705 18087291 18583988 18590585 18678890 7575488 9407949
MDC1 TP53BP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16009723 17145710 18087291 17925396 12607005
MYC PIN1 â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 11274345 11283614 16713974 16940750 17558397 17873522 19131971 19366350 19751508 19836308 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 22270359 23732914 25002027 26885856
MYC PIN1 â—¼   SHARES_COMPLEX 22.0 1.0 ACSN 11274345 11283614 16713974 16940750 17558397 17873522 19131971 19366350 19751508 19836308 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 22270359 23732914 25002027 26885856
STAT3 MYC â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
MYC VEGFA â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10432118 11274345 11283614 11875494 16327802 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21093321 21372296 21406394 21765015 2191300 22067385 22461508 23124025 23390297 25002027
STAT3 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 19289167 17204573 18184402 22317895 20067773 15184887 15469392 10464281 9325164 20654581 21573184 17959148 22349830 9874564 20581311 19259613
MYC VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 19738061 19147754 17785433 22002305 18809243 19398483 12368264 23028984
MYC PIAS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21811581 22053792 12545156 17471507
PIN1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 26655473 15048125 30723410 23716601
PDGFRB PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 10752619 8564419 1372092 7486683 7692233 7536927 16713569 11710529 8382612 8086421 11896612 8670861 8388538 9153411 1330535 17496910 1314164 16135792 7680644 19864249 10697503 15377662
PDGFRB STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17496910 9484840 25241761
PIAS2 SUMO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 16204249 21988832 25416956 19217413 16189514 14609633 16524884 12764129
PIK3R1 SPTBN1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 19345670 9918857 19438505 23168613 27795560 31066629 17764812 11027663
VEGFA PIK3R1 â—¼   ENZYMATIC_REACTION ✅ 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
STAT3 PIK3R1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11733515 24218138 23963458 15793565 16293640
PIK3R1 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17474147 19531499 25241761
PTPN13 TRIP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 10826496 17591779 10400701 16713569
STAT3 SOCS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18843197 14630083 16432158 20003295 20357037 10809230
STAT3 SOCS3 â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
STAT5A SOCS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17609438 10359822 19115200 12468433 21397011 12198248 11713228 15778369
STAT3 SOCS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 18489773 22179221 15184887 21994466 20032196 12565872 11682619 23782265 22943202 19628067 23335796 12639901 18571793 23104276 16293640 23027374 22739025 21098664 11788008 18237746 19535626 23303450 20357037 16783372 22575502 16709613 14688368 19332118 23439558 10359822 19910459 19759305 11159537 16300827 16718380
SPTBN1 SOS1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 19345670 23168613 27795560 31066629 17764812
STAT5A SPTBN1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 31066629 17764812 19345670 23168613
STAT5B SPTBN1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 31066629 17764812 19345670 23168613
STAT3 STAT5B â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 23073628 15790786 11369651 15007386 12481435 15526160 28403213 10358045 28192400 17546049 9355737
STAT3 STAT5A â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 23073628 15790786 11369651 15007386 12481435 15526160 28403213 10358045 28192400 17546049 9355737
STAT3 VEGFA â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
STAT3 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 49.0 1.0 Omnipath 22076197 19880237 12824281 20232316 18320073 20482858 17557905 21354136 19020709 17937859 20880395 25101566 16007214 19284568 19336759 20236940 10744750 11960372 15688401 19082717 21344490 20939432 17533737 21733558 18021292 20720018 11744720 23104276 16540670 11960378 20043094 21278793 21418908 15665043 15735682 21172343 23756865 20052595 17169602 18184402 21731766 23911788 12545153 22313388 16899623 20709526 18408167
STAT3 VEGFA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17987801 16716598 13130303 7768934 11528470 9278421
STAT5A ZMYM2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 21330321 14660670 17698633 10935490
STAT5B ZMYM2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 21330321 14660670 17698633 10935490
UBE2I SUMO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 47.0 1.0 Omnipath 21212807 25416956 16713569 18691969 17938407 11735126 25502805 15931224 26496610 16732283 24352468 17353931 18359863 10666456 21174150 8921390 9353268 12924945 21949651 32296183 16524884 17956732 18264111 12764129 10961991 14673145 19684601 17698038 16494873 31515488 23871147 17491593
MDC1 MDC1 â—¼   KO_DOWN_REGULATES ✅ - -3.38 3.37 PKG 28854368
TP53BP1 TP53BP1 â—¼   KO_DOWN_REGULATES ✅ - -9.54 9.53 PKG 28854368