Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
HP APOA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19758344 7258755
NAP1L1 H2BC11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20002496
HBG2 HBA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 881729 5221191
HPX HBA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20430887 8855948
HBB HBA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
HBA1 HBA2 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
HBA2 NAP1L1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
HBA2 ATP6AP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
HBA2 PTEN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
HOXB6 HBA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15269212
NFE2 HBA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17196618 12920035
DNAJC5 HBA2 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
HBB HBA2 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
CTSD HBA2 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 5219353 17112520
CPM HBA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 8635221
GATA1 HBD â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1515647 21220744
KLF1 AHSP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17069580 16705186
SP1 CD163 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10725797
DLST NAP1L1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
EIF2S2 JUN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
EPAS1 FGF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17324924 18625704
ETV6 FLI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17606295 19829305
SP1 FGF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15158147 19302822
KLF1 FLI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12556498 18523154
KLF1 FLI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12556498
FLI1 KLF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12556498
SP1 GATA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18195733 7858429
GATA2 NOS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10713142
HPX HBB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20430887 8855948
KLF1 HBE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17548470 11069894
JUN HP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12384935 22243239
MYC VCAM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11318876 10528192
PTEN SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12804776
SP1 VCAM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11133225 7499419
GSTT1 HBB â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
SP1 EPAS1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22402494 17024177
MSL2 HBB â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
PNKP HBB â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
VCAM1 HBG2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
MYC JUN â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 21150319 20232342
AHSP HBA2 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
MYC SP1 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
MYC TSC1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 28205554 29467282 28628118
HBA2 HBQ1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HuRI 32296183
JUN SP1 â—¼   PHYSICAL_INTERACTION 856.0 0.85 STRING 36370105
HBA2 HP â—¼   PHYSICAL_INTERACTION 864.0 0.86 STRING 36370105
HBA1 HP â—¼   PHYSICAL_INTERACTION 864.0 0.86 STRING 36370105
HBA2 HBB â—¼   PHYSICAL_INTERACTION 0.86 0.86 HuRI 32296183
HBB HP â—¼   PHYSICAL_INTERACTION 869.0 0.86 STRING 36370105
HBA2 HBG2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
HBA2 HBD â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
HBA2 HBE1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
EGFR HSPA8 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
ATF2 BACH1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 23661758 20102225
EGFR STAT5A â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
HBA2 KRT34 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HuRI 32296183
SP1 JUN â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 25879517 16478997 17215518 16713569 33572115 10506225
HBA2 KRT31 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
MAPK6 APOA1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
HBA2 UBE3A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
HBA2 CD163 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11196644 16189277 17008602
HBA2 CYB5R4 â—¼   OXIDOREDUCTASE_ACTIVITY_ELECTRON_TRANSFER ✅ 3.0 0.9 Reactome 15858218 10611283 15131110
HBA2 CYB5RL â—¼   OXIDOREDUCTASE_ACTIVITY_ELECTRON_TRANSFER ✅ 3.0 0.9 Reactome 15858218 10611283 15131110
HBA2 CYB5R2 â—¼   OXIDOREDUCTASE_ACTIVITY_ELECTRON_TRANSFER ✅ 3.0 0.9 Reactome 15858218 10611283 15131110
HBA2 CYB5R1 â—¼   OXIDOREDUCTASE_ACTIVITY_ELECTRON_TRANSFER ✅ 3.0 0.9 Reactome 15858218 10611283 15131110
KLF1 HBD â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21220744 8916973 10575545
NFE2 AHSP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21232177
SP1 ATF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 2145272 12760745
ATF2 NOS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16497991
DAXX ATRX â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 23329831 29084956 24981860 26496610 14990586 29937341 31628488 27029610 23222847 23135716 20147399 28875424 15252119 27872097 25416818 28875283 12953102 24651726 31631027 22102817 34162889
HBB CD163 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11196644 16189277 17008602
HP CD163 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11196644 16189277 17008602
HBB CYB5R1 â—¼   OXIDOREDUCTASE_ACTIVITY_ELECTRON_TRANSFER ✅ 3.0 0.9 Reactome 15858218 10611283 15131110
HBB CYB5R2 â—¼   OXIDOREDUCTASE_ACTIVITY_ELECTRON_TRANSFER ✅ 3.0 0.9 Reactome 15858218 10611283 15131110
HBB CYB5R4 â—¼   OXIDOREDUCTASE_ACTIVITY_ELECTRON_TRANSFER ✅ 3.0 0.9 Reactome 15858218 10611283 15131110
HBB CYB5RL â—¼   OXIDOREDUCTASE_ACTIVITY_ELECTRON_TRANSFER ✅ 3.0 0.9 Reactome 15858218 10611283 15131110
EIF1 MAPK6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
EIF2S2 EIF1AX â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 641056 592399 429297
GATA1 FLI1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 10364157 12556498 12724402 16189514
FLI1 HMOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16310515 10022513
GATA1 MAPK6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
GATA1 NFE2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16648487 20564185
GATA1 KLF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20564185 8195185 18487511
HP HBB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9315856 7378053
MYC HSPA8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11983916 12695333
JUN VCAM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9468519 16271621
MYC KLF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
SP1 MACROD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18206366 15691879
STAT5A MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17927978 12048235 12967477
MYC NAP1L1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
MYC SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11274368 16713569
TFCP2 NFE2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16648487
SP1 NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7541039
EIF1 EIF5 â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
EIF2S2 EIF5B â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
EIF1AX EIF5B â—¼   PHYSICAL_INTERACTION 936.0 0.93 STRING 36370105
EIF1AX EIF2S2 â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
AHSP HBA1 â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
HBA1 HBE1 â—¼   PHYSICAL_INTERACTION 949.0 0.94 STRING 36370105
EIF1 EIF1AX â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
EIF1 EIF2S2 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
HBA1 HBG2 â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
HBA1 HBD â—¼   PHYSICAL_INTERACTION 968.0 0.96 STRING 36370105
EIF2S2 EIF5 â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
ATRX DAXX â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
ATF2 JUN â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
HBA1 HBB â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
SP1 APOA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 22901716 11278817 10829013 15164326 15375792 11121483 23293065
HP APOA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15533931 19758344 17824618
MYC HBA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 2463629 12695333
TFCP2 HBA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 2233727 20421208 18629613 8157699 9753426 10491335
AHSP HBA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17145710 25156257 18179859 15550245 12192002
GATA1 AHSP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16186125 21232177
ATF2 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 10366004 10327051 8530413 12052888 15068801 12751796 9502786 9141200 9252389 11238729 12903123 19255142 11736649 16511568 9819389
ATF2 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 25609649 20102225 15546613 2320002 10327051 1827203 9445037 26496610 20195357 16511568 20511396 10207054 8027667 23661758 31515488 18641343 1828107
BACH1 HMOX1 â—¼   DOWN_REGULATES ✅ - 4.0 1.0 ACSN 10821856 10874044 12356737 12511571
BACH1 HBB â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 15175654 14660636 16824198 8887638 15809329
BACH1 HMOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 12511571 17942419 22107958 20083128 14747657 18550526 20501657 23737527 17257585 12356737 18771089 22698995 20345481 14580148 23479260 19439223 22735309 17409198 21982894 15233805 20643109 21555518
BACH1 HMOX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12356737 10874044 10821856 12511571
CTCF MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 10625678 8649389 2284094 12032779 19568426 24725430 12524457 8246978 12897849 9591631 1795697
SP1 CTSD â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11165043 7786196 8195246
SP1 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 1282800 17616668 18575762 19538880 15665278 18202149 20435036 21705183 18007664 21464950 23821666 15533438 9819401 10830317 8393457 16087726 20407012 18391986
JUN EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16170369 23455325 15923621 16423552 10803405 18604200
PTEN EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16288286 10648629 17218262 12040186 15584861
EGFR STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 23331499 31980649 10358079 24658140 25402006 18586824 16729043
EIF5 EIF2S2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 10805737 11092890 9395514 16189514
ETV6 STAT5A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 31066629 17764812 19345670 23168613
GATA1 FCGRT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10395650 12217383 15304324 11971001
JUN FGF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9456251 10913304 10559225 11281649 11551904 23485603 23331079
FLI1 GATA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 8510925 20110178 21205096 12724402
FLI1 GATA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12556498 12724402 16189514 10364157
GATA1 GATA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19114560 12432220 20670937 14695898 21853041
GATA1 HBB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 18586828 22164220 12556498 15358512 20564185 12556492 1559609 3243278 15833715 12379744 14695898 21220744 2461328 2911469 12193659 17196618
GATA1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 24336126 19522008 12832487
GATA2 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19522008 22951020
KLF1 HBB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 12556498 9418858 10575545 20676097 10468560 11287616 10535918 19220418 9668528 8195185 21610079 10706605 8916973 14764531 21539536 8924208 8918890 9207479 7753194 11259590 10652365 7829533 8901569 7682653 10990462 15833715 21220744 19251649 9545245 11238130 9603943 9707565 9778250 15384985 9422764 16705186
NFE2 HBB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 9478996 18308612 16287851 12582249 7918632 12000849 12379744 12031797 9558374 10891470
MYC HBB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 1904416 12695333 24725430
MYC HMOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12695333 10600159
JUN HMOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8774698 24755082 8872603 20486760 20833713 18689604
SPP1 ITGA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19417209
VCAM1 ITGA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 22623428 19738201 11751331
JUN MYC â—¼   ENZYMATIC_REACTION ✅ 40.0 1.0 ACSN 11274345 11929833 11955436 11967263 12051714 15001769 15576399 15768032 15806138 16007074 16039586 16169192 16510874 17050667 17143292 17291450 17439715 17936032 18347071 18627596 19619488 19623618 20006983 20122174 20530697 20705860 20920541 21285352 21767405 22290435 22705350 22761862 23306204 23343194 24023259 25730849 26587781 7542250 8545107 8666229
SP1 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 20148354 8355696 8892460 1406636 19437621 9054614 17502875
JUN MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 21835891 8276360 1774959 2498162 21607323 20410304 14523011 18037408
JUN SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15557322 15790955 20339243 21467818 19880446 14990565 16491116 17360982
JUN NOS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11382920 17933457 20371606 16453281 18556800 17919072
JUN MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 29.0 1.0 Omnipath 15806138 16510874 22290435 18627596 19623618 11929833 23343194 15768032 22761862 17050667 16039586 20122174 17291450 20920541 17143292 20006983 17439715 15576399 21767405 23306204 8545107 22705350 18347071 16007074 16169192 21285352 20530697 19619488 11274345
SP1 MKI67 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21611785 22890831 22125028 20963645
SP1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11470523 9492315 2284094 8437848 7753559 8355712 2057364
MYC PTEN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23135913 19578399 12695333
SP1 NOS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12759366 19105596 15722551 18624763 12684688 9614091 10574932 10713142 15061658 12270858 15180995
SP1 SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 24240095 11126367 17689681