Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
GRB2 ACTR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
BMP2 ACTR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16446785
SP1 BBC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18811981
STAT3 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11279133
EGFR CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7945309
CCND1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11279133
DDB1 IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
DNAJA1 MAP3K1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
GRB2 DNAJA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
STAT3 EGFR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6731598 14966128
AREG EGFR â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 20430953 23010081
EGFR NRAS â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
EGFR KRAS â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
EGFR HRAS â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
EGFR HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 17673906
FANCA GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
DVL2 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
PAK2 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218167 16374509
SP1 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GRB2 PPP1CB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 PRDX1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 ACTR3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 ARPC1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 MYL6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 ARPC4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 MYL12A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 MPRIP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 DYNLL1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 TGOLN2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GRB2 MYH9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 DVL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
GRB2 MYH10 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 ARPC5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 RIT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GRB2 MYH14 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 HNRNPH2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 SPTBN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
FGFR1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9480847 16713569
MYH10 IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
MYH9 IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
MYL6 IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
MYL12A IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
PPP1CB IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
MYC IKBKG â—¼   COLOCALIZATION 2.0 0.8 intact 20970423 8045055
MYC PRKACA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15197457 12420224
MYC LAMP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11085504
AKT1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17942906 9804616
STAT3 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22943793 15810077
MYH10 MAP3K1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
MYH10 PAK2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 10639334 10047984
CDC42 PAK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11278486 11804587
MYL12A PAK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15800193 10047984
PAK1 PAK2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11278486 10075701
RHOQ PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9799731
STAT3 SOX2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20132009 18447642
STAT3 CDK4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22218594
STAT3 BIRC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12393476
MED28 YAP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7033846 16964398
YAP1 SLC9A3R1 â—¼   COLOCALIZATION 2.0 0.8 intact 10562288 5211984
FBXW11 YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22017875 21900206
CTNNA1 YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 23949920 23431053
PPP1CB NF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18071304
JUN AREG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22570239 20308529
SP1 AREG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14742435
CCND3 AREG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11469683 16713569
SP1 EZR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19164283
PRKACA EZR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12840026
ITGB1 JAM3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12070135 17525755
ITGB1 JAM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12070135 17525755
MYH9 PAK2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 10639334 10047984
HRAS DVL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
JUN MAPK9 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 18793328 10871633
JUN AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12832543 11192249
JUN BMP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11044605 21898398
JUN AFP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1708774 7537266
JUN CCN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20711235 20697347
JUN BMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19009553 18495116
MAPK9 JUN â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 19527717 7148309
SP1 BIRC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19120021
HSPH1 MAP3K1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
MAP2K7 MAP3K1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11306453 9639556
RUSC1 DVL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8153045 21516116
RIPK4 DVL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1232253 23371553
DVL2 RIPK4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 16273260 23371553
DVL2 RIPK4 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 16273260 23371553
RIPK4 DVL2 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 1232253 23371553
CDC42 PTK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11817894 15788770
GLI2 BMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19103752 16880529
GLI2 BMP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18710724 20934421
SP1 KRAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8887648 19994725
SP1 FGFR4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11981041 15475466
SP1 CCN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12888575 18481199
SP1 EPHB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9918860 10751319
SP1 CLDN4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23868418 16714763
SP1 BMP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21411747 17350185
SP1 BMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12220517 19009553
GATA4 FGFR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21379568 19053175
FGFR1 AMOTL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21937427
PRKACA AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CDK4 CCND2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
PRKCA PATJ â—¼   COLOCALIZATION 2.0 0.8 intact 17235357 5219531
ARHGEF2 RHOB â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 16917499 18287519
MYL6 PAK2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 10639334 10047984
MYH11 PAK2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 10639334 10047984
PAK2 MYH14 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 10639334 10047984
PAK2 MYL12A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10047984
EPHB2 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16298995 18713744
CFTR RHOQ â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15546864 11162552
MOB1A LATS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21084559 19739119
MOB1B LATS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21084559 19739119
PRKACA AK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
GATA4 BMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23632743 24866243
TGOLN2 NCSTN â—¼   COLOCALIZATION 2.0 0.8 intact 18201567 6174903
NCSTN LAMP1 â—¼   COLOCALIZATION 2.0 0.8 intact 18201567 6174903
SOX2 NTRK3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22265740
CLDN1 PATJ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5215403 12021270
PATJ CRB3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11964389 16129888
PALS1 CRB3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11964389 16129888
PALS1 PATJ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5215229 11927608
GRB2 MAP4K1 â—¼   PHYSICAL_INTERACTION 806.0 0.8 STRING 36370105
GRB2 HCLS1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 9670936
JAM3 JAM2 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 11823489 21982860
AMOTL1 NF2 â—¼   PHYSICAL_INTERACTION 810.0 0.81 STRING 36370105
CDC42 MAP3K11 â—¼   PHYSICAL_INTERACTION 811.0 0.81 STRING 36370105
LATS1 YAP1 â—¼   PHOSPHORYLATION ✅ - 0.81 0.81 Signor 22658639
ARPC1A ACTR2 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 24981860
RHOB CD44 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
CUL1 DDB1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21145461 22474075
RHOB EGFR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
FANCA CTBP1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23303816 24469828
HUWE1 MYH9 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 25147182 26496610
MYC CUL4A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30415952 20551172
MYC CTBP1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21150319 34147029
MYC JUN â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21150319 20232342
SOX2 PAK1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
RIPK4 CUL1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 29435596 26972000
RHOB PAK2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
SAV1 AMOT â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30266805 24255178
STK3 PRDX1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23455922 23386615
RHOB DLG1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
RHOB DLG5 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
MYH11 MYL6 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33961781 26496610
LAMP1 FZD2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
STK3 MOB1B â—¼   PHOSPHORYLATION ✅ + 0.82 0.82 Signor 21808241
SOS1 KRAS â—¼   GTPASE_REACTION ✅ + 0.82 0.82 Signor 25624485
CD44 FGFR1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 15597342
MYL6 MYH10 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 24981860
TANK BIRC2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 30561431 33961781 23524849 21903422
BIRC5 CDK4 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 10713676 16189514
SOX2 PAK2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
MOB1B MOB1A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 24366813 33961781
CFTR HSPA4 â—¼   PHYSICAL_INTERACTION 832.0 0.83 STRING 36370105
DNAJA2 HSPA4 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
CCND1 CUL1 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
MYC SP1 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
LATS1 STK4 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
EGFR CD44 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 11606076 16565089 12093135 15597342 23265944
AKT1 FANCA â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 14499622 11855836
SP1 STAT3 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
MOB1B STK3 â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
AMOT NF2 â—¼   PHYSICAL_INTERACTION 845.0 0.84 STRING 36370105
KRAS NRAS â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
MAP2K7 MAPK9 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
CCND1 STAT3 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 11279133 15659654
PRDX1 MYC â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 12196529 29467282 21988832
SP1 STAT3 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 17471507 24396070 21184768 16931573
SLC9A3R1 EZR â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 11285285 5213905
CFTR MYH9 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 22038833 29924966 26618866
CFTR PRDX1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 26618866 31324722 29924966
LATS1 STK4 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 24012335 15688006 33945069
NF2 AMOT â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 24981860
JUN SP1 â—¼   PHYSICAL_INTERACTION 856.0 0.85 STRING 36370105
EZR MSN â—¼   PHYSICAL_INTERACTION 857.0 0.85 STRING 36370105
CUL4B PRDX1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 21145461 28225217
MYC HUWE1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 17314511 16269333 26279298 18488021 29467282 31677785
MAPK9 JUN â—¼   PHYSICAL_INTERACTION ✅ + 0.86 0.86 Signor 9405416
PRDX1 EGFR â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 20029029 31980649 18271526 23956138
EGFR STAT3 â—¼   PHOSPHORYLATION ✅ + 0.87 0.87 Signor 22693070
AKT1 PAK1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24886428 23397142 14749719 12138087
YAP1 MPDZ â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 25796446 26933062 30472188 33961781 24255178 24366813
CUL4A CUL1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 17079684 21145461 32235678
MYL6B MYL6 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 22939629 33961781
MYH9 MYL6 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 22863883 33961781 22939629 26496610
PAK2 RAC2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 12176041 31871319
MYH14 MYL6 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 22863883 33961781
ITGB1 PXN â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
STK3 MOB1A â—¼   PHOSPHORYLATION ✅ + 0.87 0.87 Signor 23431053
STK3 STK4 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
GLTSCR2 GTPBP4 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
AMOTL2 YAP1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
BTRC FBXW11 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
BIRC2 IKBKG â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
HRAS NRAS â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
GRB2 MYH9 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 12577067 20936779 24189400
JUN STAT3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10490649 16713569
YAP1 LATS1 â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 25283809
LATS1 MOB1A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16061636 16674920 33141042 19739119 20624913 24255178 31941533
MOB1B LATS1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 16674920 19739119 33961781 24255178 34079125 24366813 18328708
AMOT LATS1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 30266805 32292505 24101513 24255178 34079125 24366813
STK4 MOB1B â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 22863277 24255178
DLG1 KCNA3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 7477295 9341123
IKBKG TANK â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
GRB2 PTK2 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
AMOT YAP1 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
BMP2 BMPR1B â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
BTRC YAP1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
CUL4A CUL4B â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17041588 31973889 23555860 18593899 33961781 16964240 21145461 30945288 32140073
EGFR PAK1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 31980649 24658140 12522133 25402006
EGFR AKT1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24658140 25402006 31980649
MED28 GRB2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16899217 15467741
MYC SP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16713569 11274368 18003922 17418410 15780936 32115405
MYC CDK4 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22094256 28205554 28628118 21988832
MYH9 MYH10 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22939629 16596254 26496610 24981860
AMOT YAP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 30266805 23564455 24976009 24225952 25751139 31501420 32292505 29891922 30472188 24106267 24255178 24101513 32755583 24366813 19615732 22385262
SP1 JUN â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 25879517 10506225 16713569 33572115 16478997 17215518
DVL2 DVL3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24643799 31340145 33961781 28514442
FGFR4 FGF1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 1709094 25241761 10336501 10736564 33961781 7680645 11714710
STK3 MOB1A â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 18362890 31941533 24255178 23972470
STK3 MOB1B â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24255178 32296183 19919647
AMOT MPDZ â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 33961781 24255178 34079125 16678097 19615732
STK4 SAV1 â—¼   UP_REGULATES ✅ + 0.89 0.89 Signor 16930133
HRAS KRAS â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
BMP7 ACTR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 16446785
GLI2 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14691458 12533516
SOX2 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18456656 25482558
MYC CD44 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22002305 22911891 19738061
PRKACA CD44 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16785995
CUL4B DDB1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19651607 33969670 33357448 28225217 24292684 25189618 21145461 18593899 26496610 16678110 16964240 33536335 27113764 29499938 30898011 28886238 29738775 17392787 29846670 22939629 22038470 34026424 16949367 31911655 28446751 17041588 23238014 31973889 16861906 33961781 30945288 26344197 32140073
CUL4A DDB1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 22952844 17079684 22118460 15448697 26613412 22910413 25349427 21145461 22474075 27462452 16473935 15811626 18606781 26231201 18593899 16678110 16964240 33536335 19295130 25982117 33759138 16260596 27113764 21113133 30898011 28886238 26976604 27203177 17392787 25795299 22939629 26344197 14739464 27294876 10585395 27573245 31911655 17041588 20870715 27203182 31973889 32235678 16861906 19966799 22342275 34251884 17626091 19287380 30945288 16949367 32140073
EGFR STAT3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25241761 31980649 23956138 20145033 21573184 25402006 15485908 15657067 14966128 9756944 18258752 15284024 24189400 24240702 25754235 24135280 15950906 24658140 12873986 20067773 10358079
EGFR AREG â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16713569 28988771 10085134 8663535
STAT3 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18367518 21590492 23504318
FANCA FANCF â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 27986371 12724401 24469828 20347428 12973351 22705371 17082180 12444097 11750104 22343915 15082718 18550849 12649160 11063725 28215707 15262960 17396147 20064461 23303816 21109493 16116422 19321451 16720839
CDC42 GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MYC FGFR4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16846534 16489011 18562319
MYC NRAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC RHOG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC MSN â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12695333 11085504
MYC CUL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10970882 12835716
MYC AXIN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19149881 24299953
MYC BMP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC BZW1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
MYC CUL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16376880 16915296
MYC SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11274368 16713569
HRAS PAK1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15520807 17462920 20363321
NRAS PAK1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15520807 17462920 20363321
KRAS PAK1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15520807 17462920 20363321
SP1 PTTG1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12403781 14644503 18339849
STAT3 CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24287565 12147685
YAP1 BTRC â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
YAP1 LATS1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 18640976 27325643 32292505 27684187 27886176 21383157 18413746 33141042 26933062 24366813 31619268 28754671 30461308 27847303 25751139 29891922 17889669 30472188 28416659 25283809 24107629 22641346 18158288 25796446 22863277 20841485 24255178 21041411 34079125 30266805
PPP1CB MYL6 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 intact 410909200 8208729 15545284
JUN EZR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19164283
EZR PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11468295 16189514
AKT1 ITGB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16256741 10896934
HRAS PAK2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15520807 17462920 20363321
JUN RHOB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21565167 24636898
CUL1 TNIP2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12482991 14673179 11158290
MAP3K11 MAP3K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7600582 8910292 16253996
PAK2 CDC42 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 32296183 25416956 9535855 17353931 20696164 10320322 20936779 9822598 16204230 32707033 31871319 21311754
CDC42 MAP2K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9574518 9305638 23109003
GLI2 PRKACA â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 17283082 19056373 16611981
CDK4 PRDX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11986303
NRAS PAK2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15520807 17462920 20363321
KRAS PAK2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15520807 17462920 20363321
SAV1 STK3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 32707033 32296183 21988832 15688006 20920251 20562859 16930133 33961781 24255178 26186194 24981860 17379520 23455922 24366813
MOB1A STK4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 23386615 24255178 21516123 31941533
STK4 STK3 â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 24981860
STK3 STK4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 32707033 28628118 20562859 20920251 24981860 23386615 24255178 28205554 24366813 23455922 26344197
NF2 LATS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 26045165 24012335
TNIP2 BTRC â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12482991 14673179 11158290
TNIP2 FBXW11 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12482991 14673179 11158290
CTNNA1 CTBP1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
SOS1 KRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25624485 23331499 16293107
GATA4 CTNNA3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21598020 15302915
LEF1 CD1D â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15100293 20363964
MAP2K7 MAPK9 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16186825 9162092 17875933
BMPR1B GDF5 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
EZR SLC9A3R1 â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
SOS1 HRAS â—¼   GTPASE_REACTION ✅ + 0.9 0.9 Signor 23132018
CFTR SLC9A3R1 â—¼   PHYSICAL_INTERACTION 903.0 0.9 STRING 36370105
EGFR SOS1 â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
GRB2 SOS1 â—¼   RELOCALIZATION ✅ + 0.9 0.9 Signor 23452850
PTK2 PXN â—¼   PHOSPHORYLATION ✅ + 0.9 0.9 Signor 15688067
STK4 MOB1A â—¼   PHOSPHORYLATION ✅ + 0.91 0.91 Signor 21808241
DDB1 GPS1 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
FGF1 FGFR4 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
CUL4A GPS1 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
FBXW11 CUL1 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 25609649
DLG1 DLG3 â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 33961781 12351654 26496610
EGFR GRB2 â—¼   PHOSPHORYLATION 0.92 0.92 Signor 11726515
HRAS RALGDS â—¼   PHYSICAL_INTERACTION 926.0 0.92 STRING 36370105
CUL1 BTRC â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 17318178 5219675
EGFR STAT3 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
PAK1 CDC42 â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 5220560 7744004
PXN PTK2 â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 25795725
SOS1 HRAS â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 17084389 5219305
AKT1 STK4 â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 19940129 17932490
SLC9A3R1 CFTR â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 6548022 9671706
STK4 SAV1 â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 24981860
FGF1 FGFR1 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
MOB1A STK4 â—¼   PHYSICAL_INTERACTION 942.0 0.94 STRING 36370105
PTK2 PXN â—¼   PHYSICAL_INTERACTION 948.0 0.94 STRING 36370105
PAK1 PAK2 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 32707033 23455922 31980649
CCND2 CDK4 â—¼   PHYSICAL_INTERACTION 949.0 0.95 STRING 36370105
STK3 SAV1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 24981860
MSN SLC9A3R1 â—¼   PHYSICAL_INTERACTION 950.0 0.95 STRING 36370105
LATS1 STK3 â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
SOS1 EGFR â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 24797263 16713569 26005835 9447973 23956138 19531499 7510700 20473329 19289468 25754235 18271526 31959764 10675333 8621459
CUL1 GPS1 â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
MOB1A STK3 â—¼   PHYSICAL_INTERACTION 967.0 0.96 STRING 36370105
CDC42 PAK2 â—¼   PHYSICAL_INTERACTION 968.0 0.96 STRING 36370105
EGFR GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 19254954 7518560 31980649 9416834 7592693 23956138 14679214 10085134 7510700 27059931 21706016 25402006 16799092 16729043 8665853 15657067 24797263 12577067 8810325 7650032 11960376 23799367 25187647 8626525 10026169 19289468 18271526 21278786 7506413 17971399 8940013 20124286 11726515 9886492 10595738 24189400 9020117 19531499 20473329 9020193 8662998 8647858 1322798 8887653 10229072 16273093 25754235 31959764 11370743 16713569 21596750 9685397 24658140 31985874 22973453 11896612 20067773 17242169 19836242 8810340 21278788 30544639 7527043 9050991 11408594 8621459
SOS1 GRB2 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 5220480 7642581
PAK1 CDC42 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 9535855 11157984 21029865 16678097 19596003 23455922 9705280 31871319 25150978 12879077 12606577 10360579 31478661 10684602 8107774 21048135 23175184 18057010 10802735 21167153 15548653 12650940 18426980 7744004 20936779 24276241
SAV1 STK4 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 30266805 20562859 20920251 25692647 17517604 16930133 23386615 24255178 26186194 27173435 33961781 24366813 24981860 23455922
ARPC1A ARPC5L â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
CUL1 FBXW11 â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
SAV1 STK4 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
LATS1 MOB1A â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
GRB2 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 16729043 5218694
CDK4 CCND3 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 8153045 21516116
LATS1 MOB1B â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
SAV1 STK3 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
LATS1 YAP1 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
JUN MAPK9 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
CCND1 CDK4 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 28514442 25416956 25241761 8259215 9372967 29142209 9150368 18537972 16431923 33854235 24292678 9178893 33854239 9106657 14681455 8867812 8662825 17420273 19767775 16985050 19075005 12519773 21306487 26203195 24855949 23007395 11360184 10580009 11463845 17081987 8978686 16613857 15681588 21242975 15232106 9837900 24218572 27130439 10022865 25910212 9228064 12036906 23707388 23543736 27107012 23718855 19470470 31217276 10908655 8756624 25502805 17205132 33961781 20837141 19237565 21654808 11160398 7568034
ARPC4 ARPC5 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 12451597 11162547 26655834 22863883 33961781 24981860 22939629 26344197
HRAS SOS1 â—¼   PHYSICAL_INTERACTION 989.0 0.99 STRING 36370105
FGFR1 FGF1 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 16189514 25241761 10748122 8321198 23597563 1309595 11714710 9624181 11030354 7730326 11032250 28769084 1697263 22244757 1722683 22955284 10336501 8756477 18261743 18441324 1709094 8576175 33961781 8692946 1383494 18199118 10830168 14613973
CCND2 CDK4 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 28514442 16189514 14681455 32296183 9325318 11360184 30217970 28205554 15169570 10022865 17873913 25910212 27107012 28628118 33961781 26186194 11896535 9178893 11971966
CCND3 CDK4 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 28514442 16189514 25416956 21988832 33854235 9106657 14681455 21516116 23880157 16985050 32296183 10342870 26496610 19237555 9716181 11360184 30217970 15232106 14641107 25910212 27107012 16782892 33961781 26186194 11896535
ACTR3 ARPC5L â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
CCND3 CDK4 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
ACTR3 ARPC1A â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
ACTR2 ARPC5L â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
ARPC1A ARPC5 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
ACTR2 ARPC1A â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CUL4B DDB1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CDC42 PAK1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
ARPC4 ARPC5L â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
ARPC1A ARPC4 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
BTRC CUL1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CCND1 CDK4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EGFR GRB2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GRB2 SOS1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ACTR2 ARPC4 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR2 ACTR3 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR2 ARPC5 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR2 ACTR3 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR2 ARPC5 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR2 ARPC4 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
MYH9 ACTR2 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 12194823 16606694 19349987 21840487 24857661 25712372
PAK1 ACTR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16293614 10467124 14749719 9843499 16702231 10511705 12054568 8625410
MYC BBC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12695333 12384701 19815507 20145032 21835778
SP1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 10497251 22911796 19850937 9236224 17617380 9407106 15870300 22415074 10850422 9584162 10908361 22734486 16267018 9637785 19755513 11410592 11024050 15922873 12794082 20435036 22334592
MYC CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 7526316 21933022 17881732 12835716 14757441 19086036 8552398 19698176 19786833 18809243 18806825 8196642 11085504
JUN CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 16393119 21135252 8917510 17166846 19622016 11402335 20220142 22853846 17670745 10567390 17496887 19499154 9878062 21474819 17278098 15282324 15467760 15994313 14672732 15574422 22550166 10066798 17637753 20482821 15574764 11745411 11410592 18084253 20037604 12794082 10790372 16860316 24190040 17501623 17477349 19435822 10500157 11432833
LEF1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17360796 10318916 17666529 19620402 19653274 12748295 15798764 17885813
STAT3 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 16510571 19880237 17997399 15469392 16651438 21163886 22566696 16912181 22349830 16384639 12147685 21344490 20160059 19506034 20332458 23329648 11114718 17761947 22218594 15994929 21172343 18988190 18177723 24499623 21435102 19926637 18184402 17344214 22313388 23950841
CTBP1 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17666529 23343194 21285352 18974774 22761862 22290435 16039586 19619488 19623618 17143292
LEF1 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 19751508 10318916 7542250 11967263 22290435 19623618 12663502 23343194 11955436 22270359 22761862 16039586 15810077 10201372 19020303 17143292 12051714 8666229 18974774 16940750 14712077 17666529 21285352 19619488 15377999
JUN CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 18813803 19219074 16406505 16880536 16054035 19190345 17000779 17439715 8545107 16396903 11274345 20107231
MYC CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 8425218 15121849 2006410 17873522 21406394 12584560 17558397 20551172 15814658 16908182
CCND1 CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 63.0 1.0 Omnipath 26203195 17145710 8978686 12036906 23562856 25416956 16985050 23707388 19767775 9837900 17517622 19237565 9372967 25502805 23718855 9228064 7736585 15232106 11360184 20837141 21306487 25910212 25241761 27107012 9150368 18537972 9178893 31217276 8867812 10580009 23007395 11160398 19470470 19075005 9106657 8259215 10908655 8756624 23543736 24855949 7568034 24218572 8662825 31515488 17205132
SP1 CD44 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11316768 15111490 21193408 12972613 16943418 18372343 18596044 10976926 12091390 12943729
CUL4A DDB1 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
DDB1 CUL4A â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
DDB1 CUL4A â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
EGFR GRB2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 10404636 20430953 23010081 25987127 28513565
JUN EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16170369 23455325 15923621 16423552 10803405 18604200
SP1 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 1282800 17616668 18575762 19538880 15665278 18202149 20435036 21705183 18007664 21464950 23821666 15533438 9819401 10830317 8393457 16087726 20407012 18391986
AREG EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 23331499 23762360 21071413 10209155 10085134 29045902 2466334 20513444 16713569
PRKCA EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 39.0 1.0 Omnipath 11447289 8321321 11313945 25402006 12040186 20888375 15302935 6321473 1860884 12878187 6090944 19568798 14585353 17496910 21386996 24658140 2984676 11940581 31980649 15212693 85012702 19615955 2987962 12845332 3379075 7805884 10816576 15567848 16488589
EGFR GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 109.0 1.0 Omnipath 9544989 10595738 23956138 27059931 10026169 16273093 11726515 24697349 21596750 19289468 7518560 21706016 23799367 9050991 16317285 16713569 25402006 11370743 24797263 8647858 8887653 9416834 21278786 16799092 8662998 10229072 11896612 7592693 19509291 8810325 24189400 19836242 11960376 7506413 18271526 15657067 10085134 24658140 17242169 7510700 8940013 7650032 8810340 11084343 12577067 7527043 31980649 11408594 19531499 20124286 23178716 9886492 23181695 9020117 8479540 14679214 12648464 1322798 17991782 16729043 17971399
EGFR EZR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 1382070 31980649 24658140 12560083 9230083 15212693 10377409 15647376
EGFR SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9544989 19531499 9447973 16713569 12577067
EGFR PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 16713569 16919435 25402006 10806474 29435030 20473329 7657702 19339212 17496910 15657067 24658140 19625610 7529872 20802513 31980649 10545505 24043698 15951569
EGFR STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 17145710 23956138 12070153 20145033 14967450 20032199 21573184 25402006 10358079 23894143 14966128 24135280 25241761 14963038 24189400 15657067 24658140 15485908 15950906 18258752 31980649 9756944 22693070 12873986 15951569 15284024
FANCA FANCF â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 8020957
FANCA FANCF â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 8020957
FANCA FANCD2 â—¼   UP_REGULATES ✅ + 35.0 1.0 ACSN 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 8020957
FANCA FANCD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 22615860 19622404 12972610 23253856 15136767 19282663 14988723 8020957 24095737 18931676 22266823 16697054 24089143 23444773 19772495 19847258 18550849 21948210 22657828 20832754 19686080 12535671
UBE2T FANCD2 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 12239151 16916645 18931676 19264559 19622404 19686080 20457011 22615860
FANCF FANCD2 â—¼   UP_REGULATES ✅ + 35.0 1.0 ACSN 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 8020957
UBE2T FANCD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 18931676 22615860 12239151 19622404 17768402 19686080
FANCF FANCD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 22615860 19622404 12972610 23253856 15136767 19282663 14988723 8020957 24095737 18931676 22266823 16697054 24089143 23444773 19772495 19847258 18550849 21948210 22657828 20832754 19686080 12535671
FGFR1 GRB2 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 17505008 18757403 21666749 11689702 11739186 18381441 19809159 21160078 14534538 15448205
FGFR4 GRB2 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 17505008 18757403 21666749 11689702 11739186 18381441 19809159 21160078 14534538 15448205
GRB2 MAP3K1 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10086337 10465784 10567412 10811803 10982827 11274345 11447289 11668179 11777939 12040186 12048245 12175651 12419216 12640133 12738796 12782630 14585353 15170913 15567848 15574420 15863030 16102570 16227978 16488589 16582911 16887996 17496910 17496911 17673906 18855897 19449109 19568798 19615955 21102635 21614932 24027568 26552706 7510700 8551221 9379049 9582321
GRB2 KSR1 â—¼   PHYSICAL_INTERACTION 53.0 1.0 ACSN 10086337 10567412 10811803 10843677 10982827 11023813 11034387 11062502 11274345 11385609 11447289 11777939 11907067 12040186 12175651 12419216 12640133 12782630 14585353 14724641 14764585 15169888 15173823 15536084 15547943 15567848 15574420 15735649 15863030 16102570 16227978 16488589 16582911 16887996 17178906 17395718 17496910 17613518 17673906 19289794 19449109 19541618 19565474 19568798 19615955 21102635 22435554 24027568 26552706 7510700 8551221 8929532 9510155
SOS1 GRB2 â—¼   PROTEIN_INTERACTION 1.0 1.0 HIPPIE 28514442 16520382 31980649 32062451 8493579 21988832 14679214 7510700 7514169 21706016 10319320 32203420 9872323 9797459 34407391 16906159 10716926 12577067 8810325 7629168 11960376 7664271 8626525 15192046 7629138 11997436 8943292 10207103 8695800 10570290 10025673 8112292 11726515 8816480 20473329 7559490 7773779 9447984 19380743 7642581 7527391 9716598 9344843 10477741 16713569 19323566 7516467 17474147 9569023 8188688 16893902 11964172 9478994 33961781 8479541 28166272 9009162
GRB2 MAP3K1 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10086337 10465784 10567412 10811803 10982827 11274345 11447289 11668179 11777939 12040186 12048245 12175651 12419216 12640133 12738796 12782630 14585353 15170913 15567848 15574420 15863030 16102570 16227978 16488589 16582911 16887996 17496910 17496911 17673906 18855897 19449109 19568798 19615955 21102635 21614932 24027568 26552706 7510700 8551221 9379049 9582321
GRB2 KSR1 â—¼   SHARES_COMPLEX 53.0 1.0 ACSN 10086337 10567412 10811803 10843677 10982827 11023813 11034387 11062502 11274345 11385609 11447289 11777939 11907067 12040186 12175651 12419216 12640133 12782630 14585353 14724641 14764585 15169888 15173823 15536084 15547943 15567848 15574420 15735649 15863030 16102570 16227978 16488589 16582911 16887996 17178906 17395718 17496910 17613518 17673906 19289794 19449109 19541618 19565474 19568798 19615955 21102635 22435554 24027568 26552706 7510700 8551221 8929532 9510155
HRAS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
KRAS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
JUN GRB2 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 11274345 12738796 17439715 18039929 26587781 8545107
NRAS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
GRB2 KSR1 â—¼   ENZYMATIC_REACTION ✅ 53.0 1.0 ACSN 10086337 10567412 10811803 10843677 10982827 11023813 11034387 11062502 11274345 11385609 11447289 11777939 11907067 12040186 12175651 12419216 12640133 12782630 14585353 14724641 14764585 15169888 15173823 15536084 15547943 15567848 15574420 15735649 15863030 16102570 16227978 16488589 16582911 16887996 17178906 17395718 17496910 17613518 17673906 19289794 19449109 19541618 19565474 19568798 19615955 21102635 22435554 24027568 26552706 7510700 8551221 8929532 9510155
GRB2 ITGB1 â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 10086337 10426994 10567412 10811803 10982827 11447289 11777939 11777960 11907067 12175651 12640133 15536084 15567848 15574420 16339513 16582911 16713974 16887996 17070508 17100878 17496910 17673906 18490724 19449109 26552706 8551221
GRB2 MAP2K7 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10982827 11274345 11447289 11756498 11777939 12040186 12175651 12640133 12738796 14585353 15567848 15574420 15863030 16102570 16582911 16887996 17496910 17673906 18000759 18855897 19151919 19449109 19568798 21614932 24027568 26552706 27331412 7510700 8551221
GRB2 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12522133
GRB2 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 10806474 12558988 8649427 8816475 11119718 16298995 7597091 7997267 9148935 12110680 12005431 10085298 16713569 10749687 10354709 21900206
GRB2 MAP4K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 9346925 9891069 9788432 17474147 11279207
GRB2 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 145.0 1.0 Omnipath 9544989 9872323 7642581 15746962 11726515 8621483 23334917 16520382 11997436 21706016 10359574 8950973 7664271 16713569 16893902 16906159 21988832 19323566 9009162 10716926 11964172 7629168 9815779 10592173 9716598 8647802 28166272 7773778 7773779 18778683 8188688 10319320 8810325 9344843 23452850 11960376 8816480 10025673 7510700 8940013 12955078 9697839 12345678 10477741 8493579 8943292 12577067 7862167 9199344 8112292 7898932 10207103 8695800 19531499 10570290 7760801 20005866 19380743 9447984 8235613 8479540 7527391 14679214 8479541 17474147 7514169 7629138
GRB2 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17496910 16713569 17673906 11352655
HUWE1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 26279298 16915296 34761308 16969074
MAP3K1 IKBKG â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 9008162 19666475 9689078 12221085
IKBKG TNIP2 â—¼   ENZYMATIC_REACTION ✅ 38.0 1.0 ACSN 11280761 11438547 11460167 12133805 12811837 14660645 15145317 15199157 15485931 15536066 15573129 16818229 16970925 17237376 17254973 17301840 17363905 17485448 17693255 18264787 18716620 19833085 20138012 20300203 21133840 21217011 21232017 21807870 22435554 23086447 23422957 23430059 24378531 24699077 24766893 24958845 2649237 28462531
TANK IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 21988832 19854139 25861989 17468758 20484576 12133833 16189514 21419663
AKT1 IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20837477 20098747 17660512
BIRC2 IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 19223549 12867425 20301198
JUN MYC â—¼   ENZYMATIC_REACTION ✅ 40.0 1.0 ACSN 11274345 11929833 11955436 11967263 12051714 15001769 15576399 15768032 15806138 16007074 16039586 16169192 16510874 17050667 17143292 17291450 17439715 17936032 18347071 18627596 19619488 19623618 20006983 20122174 20530697 20705860 20920541 21285352 21767405 22290435 22705350 22761862 23306204 23343194 24023259 25730849 26587781 7542250 8545107 8666229
STAT3 MYC â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
JUN MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 21835891 8276360 1774959 2498162 21607323 20410304 14523011 18037408
STAT3 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 19289167 17204573 18184402 22317895 20067773 15184887 15469392 10464281 9325164 20654581 21573184 17959148 22349830 9874564 20581311 19259613
LEF1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19620402 18202148 17132729 19653274
SP1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11470523 9492315 2284094 8437848 7753559 8355712 2057364
MYC TYMS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12747840 18677108
MYC CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 7526316 11511535 10508165 9339900 15988028 20857481 11060032 14519204 14660677 10956386 21790895 11264343
MYC ITGB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11381265 16878156 12695333
MYC CDK4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 15208653 12835716 24951594 21384303 14519204 22395148 10688915 17728244 11983916 18414489
MYC BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17170079 19287963 20508797 19602047
MYC HSPA4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 1534087 14519204 1562593 10446203
JUN MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 29.0 1.0 Omnipath 15806138 16510874 22290435 18627596 19623618 11929833 23343194 15768032 22761862 17050667 16039586 20122174 17291450 20920541 17143292 20006983 17439715 15576399 21767405 23306204 8545107 22705350 18347071 16007074 16169192 21285352 20530697 19619488 11274345
PAK2 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 25326649 16081735 14749374 22020439 29695509
LEF1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 19751508 7542250 11967263 22290435 19623618 23343194 11955436 22270359 22761862 16039586 15810077 17143292 12051714 8666229 22943793 15576399 21151179 16940750 17306568 17666529 21285352 19619488
MAPK9 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10551811 34160558 26235622 25893300 25438055 20140016 33928666 11243879
DVL3 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 15806138 16510874 22290435 18627596 19623618 11929833 23343194 15768032 22761862 17050667 16039586 20122174 17291450 20920541 17143292 20006983 17439715 15576399 21767405 23306204 8545107 22705350 18347071 16007074 16169192 21285352 20530697 19619488 11274345
MYC CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 8425218 15121849 11602341 2006410 17873522 21406394 12584560 17558397 20551172 15814658 16908182
MYC CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21988832 11602341 17093053 22094256
MYH10 MYL6 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9354661 8662509 11331307 11942626
MYH10 MYH14 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9354661 8662509 11331307 11942626
MYH10 MYH11 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9354661 8662509 11331307 11942626
MYH10 RHOB â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 12185584 2966156 8702756 17151359 3839510
MYH10 PPP1CB â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 9354661 8662509 11331307 11942626
SOS1 PAK1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 19124833 9989831 15548136 19574218
AKT1 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11435472 14749719 24886428 14585966 23397142 9032240 12138087
RAC2 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9705280 23331499 10224076
CDC42 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 60.0 1.0 Omnipath 17145710 810774 10360579 21167153 8107774 10559936 9705280 12650940 16678097 23331499 21029865 10684602 18057010 15020669 21070974 11340065 21048135 15003621 20936779 10934474 11413130 15788770 15713627 9535855 23109003 11950587 19628037 7744004 12879077 12606577 24276241 10224076 19596003 8973630 19812368 11248548 10802735 18719708 10613909 10461188 23455922
PAK1 PXN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 26598620 10330411 11096073 16717130 14580336 18986306 27542844 28214467 25472536 17440071 23317503
PAK1 NF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 39.0 1.0 Omnipath 17081983 14580336 21481793 23162742 22105362 18071304 20068231 19036346 18669648 20302846 15378014 27285107 28090172 27345717 19165420 14981079 26555075 19651622 19691289 22567403 11719502 25893302 11782491
PAK1 ACTR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16293614 10467124 14749719 9843499 16702231 10511705 12054568 8625410
PAK1 CTBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 28007610 12872159 16999872 18354494 20361981 23291169
PAK1 ARHGEF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 22072711 17488622 14970201 19667072 19690332 29036929 24352660 28096473 20406887 18669648
PAK1 MAP3K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 24699410 12228228
PAK1 DYNLL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 21988832 19557173 15193260 15642175 30464262 18650427 15504720 19289209 21062069 23038268 32814053 20507214 18084006 19863079
STAT3 CCND3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16084951 18310224 15184887
STAT3 BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 19880237 26512963 15184887 15469392 16651438 18242580 16397018 21344490 20826784 24431073 15077160 12393476 19284568 17880940 17533050 17932422 22984561
MAPK9 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20871632 18691976
MAP3K1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17563747 11278353
FGFR4 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 54.0 1.0 Omnipath 19901323 10918587 9305919 8272872 12626508 16497976 15592455 17389395 12576423 11350938 11294897 12244095 9083098 8626374 9566874 11940572 11429593 14551213 11850821 17016520 9582023
BTRC YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20048001 23431053 24976009 21900206
AMOT YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 32755583 21205866 26269582 21808241
AKT1 YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 79.0 1.0 Omnipath 27979972 25360797 26804165 28273460 25751140 24101154 25751139 34052254 25362852 28114269 28793266 26265440 31239271 25601544 28474680 33630828 26119935 27144834 27425596 25531778 34206989 34465890 21945154 25195862 31792377 18640976 28775168 32015438 32523092 22234184 33536280 33622361 30600590 24362629 34155345 24658687 21060948 33162394 20153295 26668327 21730131 26549256 21666719 25605730 26039999 34226698 20823509 34516278 27033705 32064037 32271880 32513743 33990468 24812269 32053631 32929029 34058200 25772246 26364602 27765911 26678338 27979971 33552953 28171658 34129887 21376238 28416665 25998128 25109332 12535517 31988076 26933062 26598551 25373897
LATS1 YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 48.0 1.0 Omnipath 22863277 24366813 35044719 20048001 18413746 17889669 15302935 21383157 23752589 17974916 18640976 22641346 23027127 20841485 18369314 29179447 18669648 24255178 18565851 21909427 21170084 25283809 29487715 18158288 29496737 18220336 22658639 35210364 27325643 19141641 21041411 25180175 27322327 27847303
DYRK2 GLI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 19685005 21965663 21709260 12063245 18794343 25660620 9932450 18455992
DYRK2 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20831597 22307329
PPP1CB RHOB â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 9354661 8662509 11331307 11942626
MYH9 PPP1CB â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 9354661 8662509 11331307 11942626
MYH11 PPP1CB â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 9354661 8662509 11331307 11942626
PPP1CB MYH14 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 9354661 8662509 11331307 11942626
PPP1CB AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20186153 14633703
LEF1 AXIN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 19751508 7542250 8666229 11955436 11967263 22270359 16940750 12051714
BMP7 BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15621726 106311828605097 8605097 10631182
SP1 EZR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21628504 19164283
PRKCA EZR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 14504278 15531580 10970850 11387207 21899702 15843435 9516463 15647376
SLC9A3R1 EZR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 11285285 20937695 11684085 9314537 15020681 23414517
ITGB1 PTK2 â—¼   ENZYMATIC_REACTION ✅ 14.0 1.0 ACSN 12731048 18037882 19161977 19454690 19487819 20644254 20814939 22067905 22470492 24202395 9003039 9456329 9763606 9973479
PRKCA ITGB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12138200 12435334 20926684 11700305 10592173
ITGB1 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 8649427 21909923 8878413 10545505 7657702 9003039 19339212 19487819 19161977 16189514 16919435 7529872 19889638
ACTR3 ARPC5 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR3 ARPC4 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR3 ARPC5 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR3 ARPC4 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
MYH9 ACTR3 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 12194823 16606694 19349987 21840487 24857661 25712372
ARPC4 ARPC5 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ARPC4 ARPC5 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
MYH9 ARPC4 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 12194823 16606694 19349987 21840487 24857661 25712372
MYH9 MYH14 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9354661 8662509 11331307 11942626
MYH9 MYH11 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9354661 8662509 11331307 11942626
MYH9 RHOB â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 12185584 2966156 8702756 17151359 3839510
MYH9 ARPC5 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 12194823 16606694 19349987 21840487 24857661 25712372
CDC42 PXN â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10934474 11248548 11340065 15001467 15003621 15020669 15169870 15882626 16329184 17517963 17785506 18719708 19741094 21178402 22126964 22821962 27248291 7761442 9831565
PTK2 PXN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 109.0 1.0 Omnipath 16298995 26053221 15688067 15572663 15592455 7963537 17389395 25405379 26546726 9658172 15107421 22581436 10823820 16254239 25226367 15817476 10330411 9756887 19543320 9054445 10545505 18707149 29127427 15494312 10764815 7537852 9442086 33823745 12408869 20419088 20655620 22270917 18669648 28373581 10455189 16094384 23936270 19138410 22638989 11337490 11514617 27402964 16713569 7615549 10931187 11774284 26700725 27708220 20068231 20473365 28928239 7561682 34475475 28427224 28068967 8922390 24885567 23209645 27669437 15212693 26711338 9422762 11304546 28214467 26697169 12065577 28415719 10753828 11919182 24364863 9230116 11113628 21741599 10417825 15252114 24642576 22044652 21034468
HRAS KSR1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
HRAS FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
HRAS FGFR4 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
HRAS SOS1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
SP1 HRAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 8106522 8208618 3012774 11559711 21931711 8027084 1776841
SOS1 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 12628188 10208427 16713569 10913276 23331499 18454158 15507210 10592173 17673906 17496910 26721396 20133692 19141281 23132018 11560935 9447984 9690470 17084389
HRAS RALGDS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 17145710 11786539 20936779 10922060 25241761 24441586 11313862 7972015 9150145 15031288 9154803 8550624 9038168 10783161 7809086 10545207
JUN KSR1 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 11274345 12738796 17439715 18039929 26587781 8545107
SP1 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 20148354 8355696 8892460 1406636 19437621 9054614 17502875
MAPK9 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 73.0 1.0 Omnipath 17143273 17145710 17637567 12584171 20506250 11948398 15378002 16824735 9687508 8654373 20028971 12788955 9305638 15302935 26091349 33822843 18362184 17875713 16393692 9405416 17570479 1922387 18252863 25561726 7737130 10490605 17189706 11896587 34408980 11274345 20178741 8525045 16076903 7992057 19527717 7600582 17215518 8985011 11801649 19118012 11278395 8001819 8137421 19436832 16533805 8945519 12881422 9315636 10385525 12093796 14523011 19910486 15212693 8157646 12040039 11562357
PAK2 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21177766
JUN CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 18813803 19219074 16406505 16880536 16054035 19190345 17000779 17439715 8545107 16396903 11274345 20107231
JUN CCND3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 18813803 19219074 16406505 16880536 16054035 19190345 17000779 17439715 8545107 16396903 11274345 20107231
LEF1 BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17005722 19620402 11517919 16288908 17063141
SP1 BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 17350596 17876054 21131823 18175117 20660371 22334592 22734486 21433308 22773958 21093004 19120021 17124180
AKT1 CUL1 â—¼   ENZYMATIC_REACTION ✅ 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
AKT1 CUL1 â—¼   DOWN_REGULATES ✅ - 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
CUL1 GLI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17053147 15340381 16611981 18813803 16651270 12820959 19797085 15071497 15688063 16371461
KRAS KSR1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
NRAS KSR1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
MAP3K1 MAP2K7 â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10465784 11274345 11668179 12048245 12738796 15170913 15592525 17462996 17496911 18641653 18855897 19392652 21133840 21232017 21614932 23850759 24378531 9379049 9582321
MAP4K1 MAP3K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8824585 23331499 9003777
KRAS MAP3K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12228228 23331499 8649450 7744823
CDC42 MAP3K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 7600581 17161586 23109003 9487126 7601337 9305638
MAP3K1 MAP2K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 10713157 19392652 18855897 9379049 26696630 17462996 12947395 18641653 23331499 23850759 12048245 11668179 21133840 21614932 21232017 12738796 9582321 24378531 22903704 11242034 10465784 15592525 17110930 26192618 9312068 17496911 11274345 15170913
DVL2 FZD2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL2 FZD1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
PRKCA DVL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12958364 11940581 21386996 11313945 15567848
FZD4 DVL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12958364 27096005 23331499
DVL3 FZD1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
CDC42 MAP3K11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 10559936 16253996 23331499 15020669 11340065 15003621 10934474 11413130 17161586 25241761 11950587 9427749 10799501 9829970 11248548 8910292 18719708 10613909 10461188
CDC42 PAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 17145710 8107774 10559936 25416956 10320322 23331499 15020669 11340065 15003621 20936779 10934474 11413130 17353931 9535855 11950587 19628037 32296183 16204230 20696164 11248548 9822598 18719708 10613909 9823899 10461188
BTRC GLI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 17053147 15340381 16611981 18813803 16651270 12820959 19797085 15071497 15688063 16371461
FBXW11 GLI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 17053147 15340381 16611981 18813803 16651270 12820959 19797085 15071497 15688063 16371461
PRKACA GLI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 16611981 20027184 16885213 17419683 19056373 19996099
SP1 CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11160217 9339900 19753117
SP1 PRKACA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12759366 16574895 16790435 9458366 9415398 12169688 10949931 12694408 11562358
SP1 HSPA4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 7553870 9060426 2674689 24669866
SP1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19145069 15342781 21520171 18353772
SP1 TYMS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10875244 9218479 11855856
FGF1 FGFR1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 14517404 16272825 16682805 26183471 9242465
FGF1 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 49.0 1.0 Omnipath 16597617 8756477 1383494 8576175 9624181 1722683 11714710 23331499 21071413 14613973 10830168 16189514 23597563 25241761 22244757 7730326 25772309 1309595 18441324 18940940 11032250 10336501 11030354 8663044
FGF1 FGFR4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 11714710 7680645 25241761 16597617 25772309 10336501 1385111 10736564 8663044
FGFR1 SOS1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11353842 8780727 11447289 7559490 9182757
KRAS FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
NRAS FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
AKT1 STK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 19369195 20231902 20086174
AKT1 PRKACA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 20016067 23331499 17680028 20214616 17688959 20398329 16537363 17052453 19575820
AKT1 STK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 22619175 19369195 19737514 19940129 17932490 23431053 11805089 24872389 23893242 17726016
AKT1 MAP3K11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 26152725 17570479 12458207
AKT1 AGAP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19176382 21460185 22450747
CCND3 CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 43.0 1.0 Omnipath 11896535 25416956 16985050 34591612 21988832 14597415 17517622 16782892 10342870 21516116 23880157 15232106 16189514 11360184 26496610 25910212 26186194 27107012 10477583 19237555 32296183 14641107 9106657 9508775 31515488 9716181
CCND2 CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 25910212 17517622 27107012 11896535 10477583 9325318 31515488 16189514 32296183
PRKCA SLC9A3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17613530 20571032 12881487
PRKCA CFTR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 92316961 15212693 26888287 1377674
PRKCA KRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 20802526 34333552 23331499 25713064 27791178 18458061 9922370 18182391 16483930
PRKCA EPHB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 17496910 11940581 21386996 11447289 19615955 16488589 6321473 8321321 12845332 11313945 12040186 19568798 15567848 14585353
PRKCA F11R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 7646439 11027562
PRKCA PPP1R14A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 15003508 12030846 12495628 11287002 18835557 32471307 15665049 12563012 15184667 12604330 15212693
SOS1 PAK2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 19124833 9989831 15548136 19574218
PAK2 NF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 28007610 17081983 20302846 15378014 18071304 11719502 11782491 14981079
PRKACA CFTR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 28003367 23060444 25867080 21455600 30600261 1716180 28242698 19328185 32102849 92316961 19095655 14602047 7530719 10581361 11053017 9385646 25330774 15657296 1377674
SLC9A3R1 CFTR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 17145710 9671706 12471024 15553237 17110338 10852925 17244609 9677412 28360110 18754678 12403779 11158634 19446522 11304524 9613608
SAV1 STK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 20562859 21988832 17379520 24366813 16930133 26186194 17145710 24255178 20920251 21084559 15688006 32296183 29063833 23455922
SAV1 STK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 20562859 17145710 24366813 16930133 26186194 24255178 20920251 21084559 23386615 25692647 17517604 23455922
STK4 MOB1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 24255178 23386615 23431053 21808241 18328708
STK3 MOB1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23972470 18362890 23431053 21808241 32513747 30038061
STK3 MOB1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 19878874 32296183 23431053 21808241 18328708 19919647
STK3 LATS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 22195963 29970086 19962312 15688006 30038061
STK4 LATS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15688006
PRKACA NF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 15743831 33058421 22516197 18071304 17175165 16652148 16267393 18835652 11703924 15378014 17566081 27285107 14724586 14981079 11719502 25925953 17998937 11782491 26997273
PRKACA SPTBN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 9798950 20166139 20068231 18669648 17088250
PRKACA NEDD4L â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 30453017 15328345 15677482
LEF1 CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17666529 23343194 21285352 18974774 22761862 22290435 16039586 19619488 19623618 17143292
LEF1 CCND3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17666529 23343194 21285352 18974774 22761862 22290435 16039586 19619488 19623618 17143292
STK4 MOB1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18328708 22863277 23431053 21808241
FGFR4 SOS1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11353842 8780727 11447289 7559490 9182757
SPTBN1 SOS1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 19345670 23168613 27795560 31066629 17764812
NRAS SOS1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
KRAS SOS1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
SOS1 NRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 7923364 11560935 9690470 21779497 8493579
KRAS FGFR4 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
KRAS RALGDS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10783161 7809086 21988832
BMP4 BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 7811286 8702914 11282024 8006002
GDF5 BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 8702914 15890363 9525338 11282024 16127465 15569154 19229295
BMP6 BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11401330 10504300
BMP2 BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 7811286 12700180 9872992 10712517 15064755 19229295
NRAS FGFR4 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
NF2 AMOT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 19615732 24366813 26045165 21481793 26549023 23414517
PYGO2 LEF1 â—¼   PHYSICAL_INTERACTION 20.0 1.0 Reactome 12163411 16169192 11955446 18347063 17458864 22186018 15294866 16005293 16510874 19487454 9490669 17425782 19493659 18498752 17052462 22190459 18404694 11988739 17428831 22617422
MAP3K11 MAP2K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 17496910 18000759 15574420 19151919 11777939 18855897 21614932 12738796 11274345 12040186 19568798 10187804 14585353
MAP2K7 MAPK9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 11489946 9362518 18855897 23331499 9890973 11062067 21614932 12738796 11389443 11242024 12624093 11847100 16153436 16076903 17192257 15755722 19369195 19822663 14523011 11274345
MAP4K1 MAP3K11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23331499 9346925 9003777 11053428 18988627
FZD2 DVL3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
MYH11 RHOB â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 12185584 2966156 8702756 17151359 3839510
MYL6 RHOB â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 12185584 2966156 8702756 17151359 3839510
RHOB MYH14 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 12185584 2966156 8702756 17151359 3839510
MYH11 MYH14 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9354661 8662509 11331307 11942626
MYL6 MYH14 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9354661 8662509 11331307 11942626
MYH11 MYL6 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9354661 8662509 11331307 11942626
RALGDS RIT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17145710 10545207