Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
E2F4 DHFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11564866 18319725
E2F1 RRM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19416980
PTEN E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17218262
E2F4 E2F3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17531812
TP53 E2F3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20428827
E2F3 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11564866 18319725
E2F3 TYMS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15574595 10733529
E2F3 RRM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1501447 10733529
TP53 E2F4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15574328 24096481
E2F4 RRM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17531812 14688249
E2F4 NDC80 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17531812
E2F4 SP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17531812
E2F4 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12789259 18319725
E2F4 PBK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15782160 18319725
E2F4 NDC80 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18319725 16135806
KRAS ERBB2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
NRAS ERBB2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
TP53 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10766163 16713569
ESR1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 3677090
YBX1 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12446674 8163940
SP1 KRAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8887648 19994725
MYC VCAM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11318876 10528192
MYC TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11139609
NF1 NRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 2116237 2121370
PBK PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 24012691
PTEN SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12804776
SP1 SMARCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18243132
SP1 VCAM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11133225 7499419
TP53 STK11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17108107 21317932
TP53 STK11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23995788 21317932
TP53 TFDP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15574328 24096481
TFDP1 TYMS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14618416
TP53 TFDP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15574328 24096481
TP53 TH â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16133124 19618851
YBX1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12835324 16963428
TP53 YBX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18504427 22417301
USF1 TYMS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12782596
TFDP1 E2F4 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 24981860
NDC80 SPC25 â—¼   CORRELATES + 0.81 0.81 CCLE 31978347
MYC CHD8 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30415952 29467282
TP53 YBX1 â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
NDC80 SPC24 â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
ESR1 TP53 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
TP53 DHFR â—¼   KO_DOWN_REGULATES ✅ - -0.84 0.83 PKG 28854368
MYC SP1 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
E2F1 E2F3 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 35140242 24981860 20106982
E2F3 TFDP1 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
KRAS NRAS â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
PTEN TP53 â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
SPC24 SPC25 â—¼   CORRELATES + 0.86 0.86 CCLE 31978347
E2F1 DHFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11564866 8441401 18319725
E2F3 DHFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15014447 10733529 18319725
E2F4 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 14576826 10208422
SP1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10547281 8657141 10850422
E2F3 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14576826 10766737 18319725
E2F4 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14576826 10766737 18319725
E2F1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11564866 18319725 90001421
TFDP2 E2F4 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 16360038 32296183 10090723 26186194 9501179 28514442
E2F4 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17531812 12789259 20946668
E2F4 TYMS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11799066
E2F4 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11564866 12150994 18319725
ESR1 STK11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21689749 22226967 18414489
ESR1 TYMS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10875244
USF1 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 8900159 21050451
MYC YBX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12080043 18414489
MYC NRAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11274368 16713569
SH3GL2 TYMS â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
SP1 STK11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22412893 23995788
TP53 TYMS â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21351099 9260894
ESR1 SP1 â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
SPC24 SPC25 â—¼   PHYSICAL_INTERACTION 0.91 0.91 HuRI 32296183
NDC80 SPC24 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
TFDP2 E2F3 â—¼   PHYSICAL_INTERACTION 0.94 0.94 HIPPIE 33961781 7739537 8755520 26186194 28514442
SP1 TP53 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
TFDP1 E2F1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 24981860
TFDP2 E2F1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 33961781 35140242 7739537 8755520 26186194 9368098 9501179 28514442 9704927
SPC25 NDC80 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 14699129 14681455 20360068 28514442 15961401 33961781 24981860 22939629 26186194 25416956 34079125
TP53 TP53BP1 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
E2F1 TFDP1 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
E2F4 TFDP1 â—¼   PHYSICAL_INTERACTION 989.0 0.98 STRING 36370105
NDC80 SPC25 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
SP1 DHFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 9363748 1834700 8552092 1597451 8622648 9591776 9819401 11389717 11158299 1740417 1820211 12788094 3945313
E2F1 DHFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 8441401 14618416 8816912 20580656 7494286 12565705 10597240 15481443 9096302 9819401 10336493
TFDP1 DHFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16135794 14618416 18793430 11158299 12788094
E2F3 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14576826 7958836 12063292
ESR1 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22791811 20215421 12697671 10446910
TP53 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21715977 20805247 8557038 11795482 17210690 22952705
SP1 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9054613 12697671 10446910 18440323
E2F1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 8208548 2721961 7753559 11705881 24038073 8355712 1549358 1567856 12629508
E2F1 TYMS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 7623816 14679120 14618416 15280655 14726656 10914714 9748140
E2F1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22241525 8557038 15706352 21441950 12675512 23954287 12625370
TFDP2 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 26186194 9704927 9368098 8755520 9501179 7739537
E2F1 TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 20211142 15133492 22327218 7892279 16360038 9199321 8405995 9704927 8816798 9780002 8657117 9464260 22629304 7739537 27705803 25368385 9501179 8816502 8832394
E2F1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22480684 11739724 12625370
E2F3 TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8755520 7739537 8657117 8832394
E2F4 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 24573694 17132729 17699159 11689553 12757710
ESR1 ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 24559156 16115928 16467118 17992604 19915977 15199112 21127199 21761336 21907803 20551150 11713584 1358436 20629094 18768663 19005469 9242384 20889718 10698518 16467117
MYC ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20920219 21627565 7906953 23421821 20716114
ERBB2 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 15173068
SP1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 12237165 19351845 11345900 21235772 23209644 12429135 18006846 10982795 22622808 15691879 21191649
ESR1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 22396492 21835891 15073177 18193094 11517191 21505052 22892083 8707895 19569049 14722073 18414489
ESR1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 20080630 16115928 22787161 12750288 20696891 17681750 17699779
SP1 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 24019072 17023546 12576336 8756632 18793716 9503023
KRAS KSR1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
TP53 KRAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11514734 18555006 10953306 14741382 19107228 20124454 8274455 16061648 10448271
NRAS KSR1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
SP1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11470523 9492315 2284094 8437848 7753559 8355712 2057364
MYC PTEN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23135913 19578399 12695333
MYC TYMS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12747840 18677108
MYC SHMT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12138190 18628958
MYC TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 10962037 10656696 8494784 10348347 19882681 16557594 19086036 15780936 14519204 16112647 11781835 7969121 11789587 9839551
TP53 PTEN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 22957312 15843377 12917634 21637289 17344317 12839924 11545734 18172008 19173293 20554748 19079342 14984207
STK11 PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 25763354 17875968 15987703 16107342 11035045 12077256 18321849 23379765 21779440 12297295 25336918
TP53 PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 21336307 18431400 18339852 12620407 17409411 18172008 17823410 16713569 21518799 21483453
TP53 RRM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12615712 16713569
TP53 SP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 19846904 15790310 11118296 11384995 21611785 7478550 15967108 18419600 19244234 9865734 18769160
SP1 TYMS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10875244 9218479 11855856
STK11 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20815019 11430832 17108107 16713569
TP53BP1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 25579814 12110597 25837623 16713569 14978302 22653443 26022179 27546791 8016121 12351827 15611139 15364958 14985081 19433796 17805299 25651062 11877378 17634560 22084066 20307547
TP53BP1 TP53BP1 â—¼   KO_DOWN_REGULATES ✅ - -9.54 9.53 PKG 28854368