Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
ABL1 ARHGEF11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ABL1 DNM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ABL1 FYB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ABL1 ASAP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PAK1 ABL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11121037
YWHAZ ACTN4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
CD44 ARHGEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12748184 16189514
YWHAZ CLTC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
MAPK1 CLTC â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10608864 10818153
CLTC CHUK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
FOXO4 TNFSF10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23630076
IL1R2 IL1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16971486 0603545103
IL1A IRAK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8599092 9430229
IL1A IRAK4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12538665 17507369
IL1A IL1R2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16971486 0603545103
ESR1 MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23250869 22430216
MAPK1 MAP3K5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16709866
MAPK1 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15778365
ESR1 MAPK12 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16885352 22399296
MAPK3 SQSTM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7717053 20154642
MAPK3 PPP2R5B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16456541 17200115
TP53 MAPK3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21187340 16050810
MAP3K14 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12049732 16691505
MAPK3 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16888388 16691505
MAPK3 GATA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22227582 11585926
MYC ARF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219602 17289033
MYC YBX3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12747840
MYC PDGFRB â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15226411 18697203
MYC PRKACA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15197457 12420224
ESR1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 3677090
AKT1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17942906 9804616
UBC NEDD4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7104155 19343052
MAPK11 PAK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PAK3 PAK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11278486 10075701
RAC1 PAK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11278486 11804587
PPP2R2A TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219546 17245430
TP53 PPP2R1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219546 17245430
TP53 PRKAA2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15866171 24874608
TP53 IFNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17564708 24180280
PIK3R3 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 32606738
TP53 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10766163 16713569
TP53 MMP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
TP53 PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7915517
ARPC2 ACTB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10592173 9600938
VASP ACTB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10592173 1318192
ACTB ARPC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10592173 9600938
HSPA8 PRKAA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 26902588 25961502
CRKL ERBB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
CRKL MAPK8 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7033842 16982329
CRKL ABI1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7907811 20598684
ACTG1 MAP3K14 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
ACTG1 CHUK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
CALM2 RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9813038 8918462
UBA52 H3-4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
CGN YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
GATA4 KDR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23284745 21354132
FBXW11 KDR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22711876 21900206
ARHGEF11 PLCG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ABI1 PLCG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7907811 20598684
ASAP1 PLCG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PLCG1 ALK â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18097461 9819383
PLCG1 ASAP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
MAP3K7 SHARPIN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16260783 16953224
TAB3 RBCK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16260783 16953224
ESR1 CCL5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12603855 26790618
CYBA NOX1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12716910 16762923
RAC1 CYBA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16189514 10486263
TUBB4A CHUK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
CAPZA1 CHUK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
RPS6KA5 RELA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216210 12628924
RELA CFTR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11114294
RELA MAP3K14 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15047705 22685329
MAP3K14 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18439422
PPP2R2A KSR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 15664191
KSR1 YWHAZ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9115393 9858547
PAK3 RAC1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11278486 10075701
ESR1 RAC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21118977 11060289
ARHGAP1 RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9535855 14749388
RAC1 CYFIP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9417078 16189514
UBC YWHAB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
YWHAB MARK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
YWHAB AFDN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
UBC RHOA â—¼   UBIQUITINATION ✅ 2.0 0.8 intact 5217531 15710384
RHOA GATA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22758628 12878473
RHOA AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15884057 11748077
TAB3 SHARPIN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16260783 16953224
GATA4 FGFR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21379568 19053175
FGFR1 AMOTL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21937427
YWHAZ IGF1R â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6547842 9581554
PIK3R3 IGF1R â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0611271104 17360667
ARHGEF12 IGF1R â—¼   COLOCALIZATION 2.0 0.8 intact 11724822 5214835
PKN1 AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1218925110 23223530
PRKACA AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MAPK8 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16306447
PTPRF AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15896785
BMI1 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6948569 19233177
ESR1 BMI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24559156 16582100
AKT3 BMI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22505453
ARHGEF2 RHOB â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 16917499 18287519
IRAK1 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218906 16884718
GNA12 ARHGEF11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11799111 10026210
ESR1 GNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19170076 18414489
ZRANB1 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19373254 7288828
ASAP1 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17255943 5219572
UBC YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
UBC ZRANB1 â—¼   DEUBIQUITINATION ✅ 2.0 0.8 intact 19373254 7288828
PPP2R5A PPP2R1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219546 17245430
PRKACA CACNA1D â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19074150
CAPZB DCTN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15473859 15738427
CAPZA1 DCTN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15473859 15738427
DCTN1 HDAC6 â—¼   COLOCALIZATION 2.0 0.8 intact 5215415 12024216
PPP6R2 PPP6C â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8208117 16769727
PPP6R1 PPP6C â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8208117 16769727
HSPA4 YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
ABI1 HSPA8 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15048123 5216987
YWHAQ HSPA8 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
HSPA8 MAP3K14 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSPA8 VASP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
HSPA8 YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
ESR1 HSPA8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11085516
ESR1 YWHAQ â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22329840
ESR1 MMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18313050 19861308
YBX3 MAP3K14 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TUBB4A MAP3K14 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TUBB2B MAP3K14 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
CAPZB CAPZA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
ACVR2B ACVR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16446785
ACVR2A ACVR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9748228 8612709
BMPR1A ACVR2B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7644468 7791754
VASP PFN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
H3-4 ARHGEF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
PFN1 YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
CEP170 YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
H3-4 RAPGEF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
YWHAZ RAPGEF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
VCL YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
YWHAZ AFDN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
PALS1 CRB3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11964389 16129888
SEPTIN6 SEPTIN2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
NEDD4 AKT1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 19953087 23195959 31390487
UBC SQSTM1 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 5216530 12857745
CFTR YWHAB â—¼   PHYSICAL_INTERACTION 812.0 0.81 STRING 36370105
CFTR YWHAZ â—¼   PHYSICAL_INTERACTION 812.0 0.81 STRING 36370105
MARK3 YWHAH â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
ACVR1 BMPR2 â—¼   PHYSICAL_INTERACTION 814.0 0.81 STRING 36370105
PCNA UBA52 â—¼   PHYSICAL_INTERACTION 816.0 0.81 STRING 36370105
ESR1 YWHAB â—¼   PHYSICAL_INTERACTION 818.0 0.81 STRING 36370105
RHOB CD44 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
MYC MYO5A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17353931 29467282
MYC DCTN1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17353931 29467282
PAK1 ESR1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 16452229 12374744
ESR1 RAP1A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19805454 31527615
PTPRF RHOA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31871319 25458010
IGF1R ERBB2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17307140 30898150
AKT3 AKT1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
BMI1 CAPZB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24457600 34316702
CFTR DCTN1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 26618866 31324722
RHOB MARK3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
ESR1 MARK2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19805454 31527615
WASF3 ABI1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
RHOB MARK2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
RHOB TULP3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
ARF6 CYTH3 â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
RHOA MAPK8 â—¼   PHYSICAL_INTERACTION ✅ + 0.82 0.82 Signor 8824197
ARHGEF1 RHOA â—¼   GTPASE_REACTION ✅ + 0.82 0.82 Signor 10836144
CYFIP1 WASF3 â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
CD44 FGFR1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 15597342
AKT1 FOXO4 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 10217147 16272144 15688030 11313479 11689711
SHARPIN RBCK1 â—¼   PHYSICAL_INTERACTION ✅ 0.83 0.83 mint 23032186 8410237
CCL5 SDC1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16189514 14637022
YWHAB IGF1R â—¼   PHYSICAL_INTERACTION ✅ 0.83 0.83 mint 9581554 6547842
FLT1 FLT4 â—¼   PHYSICAL_INTERACTION 829.0 0.83 STRING 36370105
HDAC6 CFTR â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 31501480 22069321 14675537
ESR1 ACTN1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 23403292 21182205 19805454 31527615
CFTR HSPA4 â—¼   PHYSICAL_INTERACTION 832.0 0.83 STRING 36370105
ESR1 TP53 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CALM2 ESR1 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
MYC ACTB â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 11839798 29467282
TIRAP IRAK1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 33961781 21903422
ESR1 IGF1R â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10749889 24051437 14764897 28555617 16113100
MARK2 CAPZB â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 32707033 26496610
IRAK1 MAP3K7 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
BAK1 TP53 â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
ACTN4 VCL â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
ACTN4 ESR1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 21078666 19805454 25604459
PLCG1 PDGFRB â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 6730306 1396585
ARF1 ASAP1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16223492 16332543
AKT2 AKT1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 28514442 12149249 9736715 12176337 11445557 33961781 14500673 11278835 11546794
RHOB PKN1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 34079125 31871319 34187934
PAK3 RAC1 â—¼   PHYSICAL_INTERACTION 850.0 0.85 STRING 36370105
MARK2 YWHAZ â—¼   PHYSICAL_INTERACTION 851.0 0.85 STRING 36370105
CHUK RELA â—¼   PHOSPHORYLATION ✅ + 0.85 0.85 Signor 10521409
MARK2 YWHAH â—¼   PHYSICAL_INTERACTION 857.0 0.85 STRING 36370105
ABL1 ERBB2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 22973453 16273093 19275932
PLCG1 ALK â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 11888936 9819383 14968112 9174053
HDAC6 ERBB2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 20029029 31980649
IGF1R PIK3R3 â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
PCNA UBC â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
ACVR2B BMPR1A â—¼   PHYSICAL_INTERACTION 864.0 0.86 STRING 36370105
ACTB CAPZA1 â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
MYC UBC â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 21150319 16996503 19131971
MYC WDR5 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 17353931 27320920 35140242 29467282 31767764 30415952
AKT1 PAK1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24886428 23397142 14749719 12138087
ESR1 ACTB â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 31527615 20308691 19805454 21182203 21182205 20348541
IRAK4 TIRAP â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 18221795 21903422
RHOA ARHGEF11 â—¼   PHYSICAL_INTERACTION ✅ 0.87 0.87 mint 7909059 20300064
MARK2 MARK3 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 32707033 19615732
NEDD4 UBA52 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
ACTN1 VCL â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
UBA52 UBE2V2 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
AKT1 CHUK â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
CFTR HSPA8 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
ALK PLCG1 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
CHUK MAP3K7 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
ARHGAP1 RHOA â—¼   GTPASE_REACTION ✅ - 0.87 0.87 Signor 32203420
HSPA4 PARK2 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
HDAC6 SQSTM1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
HSPA8 TP53 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
HSPA4 TP53 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
MAPK1 TP53 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
FLT4 KDR â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
ABL1 ABI1 â—¼   PHOSPHORYLATION ✅ + 0.87 0.87 Signor 21320496
ACTB CAPZB â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
PDGFRB PLCG1 â—¼   PHOSPHORYLATION ✅ + 0.87 0.87 Signor 7535778
CHUK RELA â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
ABL1 PLCG1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10708759 1383690 17474147
ACTN1 ACTN4 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 22863883 22939629
NEDD4 IGF1R â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 12697834 18286479 18632619 19165858
RBCK1 UBC â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
PKN1 ACTN1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 9030526 16189514 16713569 11802708
TNIP1 UBC â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
MAP3K5 YWHAZ â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
ESR1 HSPA8 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
TAB3 UBC â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
ESR1 HSPA4 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
YWHAB YWHAH â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
YWHAH YWHAZ â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
MAPK8 TP53 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
YWHAB YWHAZ â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
MAPK1 MAPK3 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
CD44 ERBB2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11606076 28628118 12093135 17092940 28205554
PPP2R1A CFTR â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 5217765 15936019
CFTR PPP2R1A â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 5217765 15936019
CAPZB DCTN1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 33961781 27173435 26344197
VASP ABI1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 32296183 16055720 26186194 34079125
BMPR2 ACVR1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 7890683 28514442 7791754
IRAK1 IRAK4 â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
MARK3 YWHAB â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
ACVR2A BMPR1A â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
MARK3 YWHAZ â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
ABL1 ABI1 â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 5219329 17101133
CRKL ABL1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16443220 22286129 7493940 14604282 8978305 9820532 18835194 9710592 33961781 8524328 19823681 7926767 16955467 24412932
MYC ABL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21400515 23029531 19602047
TP53 BAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16713569 15077116
MYC CASP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MMP2 CD44 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16631740 11872628 1707285
MYC CD44 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22002305 22911891 19738061
PRKACA CD44 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16785995
YWHAZ FOXO4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 14690436 8006586 0352724
FOXO4 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11896584 11313479 11689711
MAPK1 RAP1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 27503831 16939974 9560161
MAPK1 YWHAB â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 27503831 16939974 9560161
MAPK1 RAC1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 17202194 15657136 21419341
RHOA MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10617617 9854026 12810709
ARF6 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17363898 16452216 15210957
MAPK1 GATA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11585926
MAPK3 RAP1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 27503831 16939974 9560161
MAPK3 YWHAB â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 27503831 16939974 9560161
MAPK3 RAC1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 17202194 15657136 21419341
RHOA MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10617617 9854026 12810709
ARF6 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17363898 16452216 15210957
MAPK3 ABI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21419341
MAPK3 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 14993270
MYC ACTG1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC HSPA8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11983916 12695333
MYC AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16846534 16489011 18562319
MYC UBA52 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC CUL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10970882 12835716
MYC PIK3C3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
MYC SQSTM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC ARF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC RHOA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22159222 20383141 22235332
MYC PEX14 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
RELA MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12027803 16713569
MYC CUL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16376880 16915296
FGFR1 NEDD4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19953087 25292214 21765395
ERBB2 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9774445
SQSTM1 IRAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12034707 10747026
TP53 HSPA8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 31027880 18431400
PRKACA PRKAA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19942859
PDGFRB CRKL â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10508235 9546424 9739761
PDGFB CRKL â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10508235 9546424 9739761
CRKL MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10592173 9710592 16982329
RPS6KA5 ACTG1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CALM2 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9859994 2550447 19608982
PDGFRB PIK3CB â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 2466336 1374684 9739761
PDGFRB PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17496910 16189514 11172806
PDGFB PIK3CB â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 2466336 1374684 9739761
PDGFB PLCG1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 1396585 8443409 9739761
KDR FBXW11 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
AXL PLCG1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 9178760 8026679 1201123
PLCG1 FGFR1 â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 8321198 6730542
FGFR1 PLCG1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12601080 1689310 1656221 25241761 23063561 8321198 9660748 20932831 18022941 19665973 15117958
PLCG1 ERBB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 22973453 16273093 1676673 1683701
FGFR1 PLCG1 â—¼   PROXIMITY ✅ 0.9 0.9 mint 8019672 20932831
PLCG1 FGFR1 â—¼   PROXIMITY ✅ 0.9 0.9 mint 8019672 20932831
PPP6C MAP3K7 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 intact 608155200 17079228 8204431
IRAK4 IRAK1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 24735611 12860405 19166926 18221795 12538665 17785851 11960013 16024789 16951688 17276401 21903422
CYTH3 ARF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18451304 9707577 10652516
ASAP1 ARF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11773070 16223492
AKT3 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19609947
RELA MMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19303700 20352621 17498959
AKT1S1 YWHAB â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 8008321 18372248 800723200
ERBB2 RHOA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
PKN1 RHOA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 8571127 31871319 10619026 12773565 9446575 9535835
ARHGEF11 RHOA â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 12220504 15210733 12730235
RHOA ARHGEF12 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 12220504 15210733 12730235
RHOA PFN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22820501 22479341 27228149
AKT1 DCTN1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
AKT1 PPP2R5B â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 Reactome 1325671 17200115 19576174
AKT2 BMI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23092893 22505453
MARK2 ARHGEF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 22072711
PKN1 ARHGEF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 14970201
HSPA8 CFTR â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 25961502 2799391 2204156
RHOD ARHGAP1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 31871319 27481945 27852748
ARHGEF11 RHOB â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 12220504 15210733 12730235
RHOB ARHGEF12 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 12220504 15210733 12730235
GNA12 ARHGEF12 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12515866 11094164 12024019
PPP2R1A GNA12 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 8238530 15525651 400508200
ESR1 PRKACA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11457657 10949931 17068199
AKT2 MYO5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17515613
HSPA8 HDAC6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 25961502 2799391 2204156
HSPA8 MAPK8 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
GATA4 ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19276186
ERBB2 PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16273093 17496910
AKT1S1 RPS6KA5 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MAPK8 BMPR2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
PIK3CB ALK â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11280786 11110708 18097461
ACVR2B BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 17295905 16446785
ABL1 CRKL â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
PARK2 UBA52 â—¼   PHYSICAL_INTERACTION 902.0 0.9 STRING 36370105
CHUK MAP3K14 â—¼   PHYSICAL_INTERACTION 904.0 0.9 STRING 36370105
ACTB ACTG1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HuRI 32296183
RHOA ROCK2 â—¼   PROTEIN_INTERACTION 0.91 0.91 HIPPIE 31871319 11350930
YWHAH MARK2 â—¼   PHYSICAL_INTERACTION ✅ 0.91 0.91 mint 19553522 8009002 0803887
YWHAZ MARK2 â—¼   PHYSICAL_INTERACTION ✅ 0.91 0.91 mint 5217040 15161933
RHOB ROCK2 â—¼   PROTEIN_INTERACTION 0.91 0.91 HIPPIE 34079125 31871319
HSPA4 HSPA8 â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
ABI1 CYFIP1 â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
ARHGEF11 RHOA â—¼   GTPASE_REACTION ✅ + 0.91 0.91 Signor 32203420
PXN VCL â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
ARHGEF12 RHOA â—¼   GTPASE_REACTION ✅ + 0.91 0.91 Signor 11094164
PKN1 RHOA â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
UBC WDR5 â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
FBXW11 CUL1 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 25609649
CUL1 UBC â—¼   PHYSICAL_INTERACTION 925.0 0.92 STRING 36370105
SQSTM1 UBC â—¼   PHYSICAL_INTERACTION 926.0 0.92 STRING 36370105
YWHAZ MARK3 â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 5217040 15161933
PIK3CB PIK3R3 â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
AKT3 MAP3K5 â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
MAP3K14 CHUK â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 16498412 5218365
HK1 RHOA â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
ACTB PFN1 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
ABI1 ABL1 â—¼   PHYSICAL_INTERACTION 948.0 0.94 STRING 36370105
ACTG1 ACTB â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 8153045 21516116
PPP2R2A PPP2R1A â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 17245430 5219546
RRAGD RRAGB â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 18497260 33961781 28716898 11073942 20381137 24337580 22424946
UBA52 WDR5 â—¼   PHYSICAL_INTERACTION 951.0 0.95 STRING 36370105
ACTN1 ACTN4 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
AKT1 MAP3K5 â—¼   PHYSICAL_INTERACTION 953.0 0.95 STRING 36370105
RRAGB RRAGD â—¼   PHYSICAL_INTERACTION 953.0 0.95 STRING 36370105
ACTR3B ARPC2 â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
UBA52 UBC â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
UBC TP53 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 17568776 5220017
RAC1 PAK3 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 11478794 25301945 11862216
PPP6C PPP6R2 â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
PPP6C PPP6R3 â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
ACTR2 ACTR3B â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
PPP6C PPP6R1 â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
ACTR3B ARPC4 â—¼   PHYSICAL_INTERACTION 967.0 0.96 STRING 36370105
AP3B1 ARF1 â—¼   PHYSICAL_INTERACTION 967.0 0.96 STRING 36370105
ABL1 ABI1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 17101133 9593709 12672821 9010225 18328268 8943360 20598684 11418237
KEAP1 SQSTM1 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
HDAC6 UBC â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
CUL1 FBXW11 â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
PDGFRB PLCG1 â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
FGFR1 PLCG1 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
RAC1 PAK1 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 5217506 15688026
ARPC2 ARPC4 â—¼   PROTEIN_INTERACTION 0.98 0.98 HIPPIE 11805826 11162547 22863883 33961781 24981860 22939629 26344197
ARHGEF11 RHOA â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
ARHGEF12 RHOA â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
ARHGAP1 RHOA â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
UBC ZRANB1 â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
FLT1 KDR â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
UBC USP21 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
NEDD4 UBC â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
ITGA2B ITGB3 â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
UBC UBE2V2 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
PAK1 RAC1 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 24625804 19327867 15143066 9535855 17245428 11134022 15673687 15289329 16492808 16551621 21029865 16678097 19596003 26175416 17389360 31871319 24056087 25843002 25150978 12879077 15212766 19693014 11030651 16630611 20810653 8107774 11130076 25468898 29615491 19732720 19270716 21474670 10706722 19277120 10802735 21167153 24172987 21454543 15548653 16002993 12650940 18426980 19961560 11950930 24792722 15688026 7744004 20936779 25819133 15075243 22581261
CAPZA1 CAPZB â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
PARK2 UBC â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
PAK1 RAC1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PPP2R1A PPP2R5B â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PPP2R1A PPP2R5E â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PPP2R1A PPP2R5A â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PPP2R1A PPP2R2A â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
ABL1 CRKL â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 10837221 15459660 18835194 21051857 21199784 21435002
ABL1 CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 22553782 24974292 29066624 15657060 20841568 28177918
ABL1 PXN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 7615549 15817476 11774284 16254239 15107421 12408869 15572663 11695992 15592455 16094384 10823820 20841568 16713569 9603926 7537852
ABL1 CRKL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 55.0 1.0 Omnipath 8978305 22581121 20841568 10837221 18768933 7493940 9710592 16955467 8524328 23331499 21199784 18794134 10592173 21051857 7926767 16443220 18835194 24165979 26500649 18809728 15459660 26192618 24412932 9053848 22286129 8083188 14604282 21435002 9820532 19823681
ABL1 PDGFRB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 14993293 19275932 20841568
ABL1 DNM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17474147 20841568 19833721
ABL1 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 10708759 19290927 12652307 1383690 16525023 8657103 20841568 17474147
ABL1 WASF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17623672 23354023 20841568
ABL1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 20841568 20101225 30692633
ABL1 ABI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 48.0 1.0 Omnipath 17145710 20598684 18328268 12591740 9593709 20841568 18083107 7590237 11418237 12672821 17389395 19534553 8943360 17101133 9010225 11163214 26428302 21320496
ACTR2 ARPC4 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR2 ARPC2 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR2 ACTR3 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR2 ACTR3 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR2 ARPC4 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR2 ARPC2 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
PAK1 ACTR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16293614 10467124 14749719 9843499 16702231 10511705 12054568 8625410
TP53 BAK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 22983126 18519674 21233848 15033822 15489892 15105295 10741712
AKT1 CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 42.0 1.0 Omnipath 11756412 11923280 16697215 20398329 18372248 15004527 15808505 20138985 20214616 15703181 17570479 28177918 18840507 15169778 11714830 10949026 16341064 11715018 18636226 10529400 9812896 17680028 19440551 10722653 20832730 18570873 17052453
PRKACA CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 29352269 15703181
AKT2 CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 9812896 15004527
AKT3 CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9812896
MAPK3 CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 38.0 1.0 Omnipath 15547943 20080742 29416675 12040186 15173823 12697810 11940578 19081073 19586613 16227978 12738796 16039586 17466630 17255949 18669648 15187187 19016842 19541618 19091303 19565474 17052211 18039929 18775330 10601235 12792650 11431469
MAPK1 CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 44.0 1.0 Omnipath 15547943 20080742 12040186 18083711 15173823 12697810 11940578 19081073 19586613 16227978 12738796 16039586 17466630 17255949 18669648 16888006 15187187 19016842 19541618 19091303 19565474 17052211 18039929 18775330 10601235 12792650 11431469
DNM2 CLTC â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10480952 7650016 7592972 10593899 14731593 2121367 9497313 8939989
DNM2 CLTC â—¼   GTPASE_REACTION ✅ 7.0 1.0 Reactome 10480952 7650016 7592972 10593899 2121367 9497313 8939989
AKT1 FOXO4 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 15987244 10358075 10102273 12857750
MAPK8 FOXO4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11689711 20959475 17570479 15538382 15212693
AKT3 FOXO4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 19216069 17680028 11756412 16680151 20214616 11463845 20452955 9829964 20398329 17646672 10217147
AKT1 FOXO4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 58.0 1.0 Omnipath 11756412 20452955 21798082 20398329 15538382 10217147 23331499 19216069 20214616 11463845 23180781 9829964 11313479 10102273 10518537 14690436 16680151 17646672 18988627 17522590 11896584 16272144 11689711 17680028 21620960 19664994 11864996
AKT2 FOXO4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 26.0 1.0 Omnipath 19216069 11896584 17680028 11756412 16680151 20214616 11463845 21620960 19664994 20452955 9829964 16272144 20398329 11313479 15538382 17646672 10217147
RELA IL1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 27371733 21131967 23195252 17612514 27076634 21106671
IL1A IL1R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 25241761 16971486 7878046 1833184 9862719 23395675 78780467878046
SQSTM1 KEAP1 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 15340068 16252010 20531300 21981924 23850759 25002027 26587781 26653790 26794443 27048822 28574505
SQSTM1 KEAP1 â—¼   PROTEIN_INTERACTION 11.0 1.0 ACSN 15340068 16252010 20531300 21981924 23850759 25002027 26587781 26653790 26794443 27048822 28574505
SQSTM1 KEAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 34.0 1.0 Omnipath 20378532 35044719 20495340 25416956 25939382 23117207 32075457 20452972 24322982 20562859 25910212 26043024 33397898 23795962 27631370 33603948 20421418 32296183 23242280 19615732 31169361 20173742 24011591 21482715
MARK3 MAPK1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 25435214 20179705 20141835 16364920 20130576 15035987 25907612
MAPK1 KSR1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 25435214 20179705 20141835 16364920 20130576 15035987 25907612
FGFR1 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MAPK1 CUL1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 31434245 22955283 12748172 16009132
MYC MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22789855 21933022 16596619 23617883 8013639 20144848
KSR1 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 19219045 19541618 8226933 10567369 1330321 7992057 9858547 8248196
MAPK1 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12975377 23602568 16424009 19058874 23397142 21707490
MAPK1 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 27342992 23405013
MAPK1 TNIP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 21988832 12220502 26046540 16713569
MAPK1 ABI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19917258 17855441 21419341 21900237
MAPK1 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 19604315 15542607 16964243 15212693 11604394
MAPK1 PXN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10753946 15494312 11784715 14636584
MAPK1 RPS6KA5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 46.0 1.0 Omnipath 20506250 15547943 18267068 15302935 12697810 11940578 12414794 17117922 23331499 21071413 23047924 20068231 16393692 9687510 17255949 15187187 19541618 19565474 17052211 15568999 19651622 14578350 11018520 15684425 11994045 11274345
MAPK1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 15655247 10949034 15528270 18372406 15461668 12118371 12466266 7495695 17615152 15059947 16076840 7491495 12093745 10409727 9528769 7838153
MAPK1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 10551811 17081983 8386367 17251036 91332050 17570479 1748630 7957875 27167001 15212693 1651323 15210690
MAPK1 PPP1R9B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 21704645 15980451 15728359
MAPK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 14965474 9765199 15116093 21675959 23443559 10781582 25241761 10446957 10958792 11409876 11709713 21147777 10673501 11551930 15867353 11875057 12091386
MAPK1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15073167 16888388 16691505
MAPK1 ARHGEF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18211802 19261619
MAPK12 RPS6KA5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15187187 19436832 15140942 20506250 21614932 16393692 11274345
MAPK12 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15187187 19436832 15140942 20506250 21614932 16393692 24818748 11274345
MAPK3 KSR1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 25435214 20179705 20141835 16364920 20130576 15035987 25907612
MAPK3 MARK3 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 25435214 20179705 20141835 16364920 20130576 15035987 25907612
FGFR1 MAPK3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MAPK11 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12738796 18039929 11274345 15187187
KSR1 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19219045 19541618 8226933 10567369 1330321 7992057 8248196
MAPK3 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 18463697 9155018 21071413 32482868 18988627 15210690
MAPK3 ARHGEF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 28096473 24043311 18211802 19261619
MAPK3 RPS6KA5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 20506250 15547943 15302935 12697810 12414794 17117922 20068231 16393692 19251839 17255949 15187187 19541618 19565474 18813292 17052211 15568999 19651622 14578350 11891214 11018520 15684425 11994045 11274345
MAPK3 HDAC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 24089523
MAPK3 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 10781582 11239457 10958792 28937686 9467949 10348343 24194938 9739174 16713569 12955074 10747897 17237827 25767119 18523266 12393879
MAPK3 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 10949034 18372406 15461668 9528769 12118371 14680484 17615152 15059947 16076840 7491495 12093745 15212693 15528270 7838153
MAPK3 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 27342992 23405013 18411303
MYC BMI1 â—¼   UP_REGULATES ✅ + 32.0 1.0 ACSN 11274345 11283614 12545156 14536078 15147722 15155580 15279786 17055429 17303408 17550342 17558397 17660363 17873522 18590585 18636226 20027199 20237412 20551172 20581311 20713526 20818389 21406394 21733352 2191300 21919891 22067385 23140366 23869868 25002027 28536364 7575488 9618481
RELA MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 12894581 18184402 7869034 17673602 12783888 11114727 17944672 9596659 19469019 21790895 19766095 17018379 8289784 18566231
ESR1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 22396492 21835891 15073177 18193094 11517191 21505052 22892083 8707895 19569049 14722073 18414489
MYC TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 10962037 10656696 8494784 10348347 19882681 16557594 19086036 15780936 14519204 16112647 11781835 7969121 11789587 9839551
MYC PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 7597041 18358094 22911891 18809243 1280813111085504 11085504
MYC ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20920219 21627565 7906953 23421821 20716114
MYC HSPA4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 1534087 14519204 1562593 10446203
CHUK MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17306568 17666529 23343194 21285352 15576399 21151179 22761862 22290435 16039586 19619488 19623618 17143292
PPP2R5A MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19131971 10026142 10995457 18042541 18559511 16680151
MAPK8 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 19651622 10551811 17081983 18767875 20068231 91332050 1651323 1748630 16713569 11243879 18669648 15210690
NEDD4 IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 21071413 18988627 12697834 19165858
PLCG1 PAK1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 19124833 9989831 15548136 19574218
RAC1 PAK1 â—¼   UP_REGULATES ✅ + 11.0 1.0 ACSN 11121431 11274345 11544274 11756498 15157156 15229651 18000759 19151919 24459205 27331412 9655398
RAC1 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 130.0 1.0 Omnipath 17145710 15229651 21167153 8107774 24792722 16551621 14579272 10023776 8805275 18325335 11134022 19693014 19277120 21474670 12650940 15673687 19961560 20711231 11950930 16678097 12123608 19270716 9744077 9148763 11689432 23331499 21029865 16368433 11121431 16492808 15075243 21454543 10592173 24172987 15212766 7493928 10793146 21070974 10706722 8910277 17245428 25819133 20936779 11030651 9989831 15157156 9535855 19359598 25150978 16049136 18854161 19628037 15688026 12879077 7744004 11728826 16002993 9764820 9032259 25843002 10224076 19732720 19596003 10802735 19893577 16212495 11130076 12480336 11152757 19327867 22117219 22581261
AKT1 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11435472 14749719 24886428 14585966 23397142 9032240 12138087
PAK1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 18521086 26944939 16778166 18755239 21893191 15178330 19205871 29548483 26554417 27003261 24505617 16452229 15193262 19557173 15642175 12374744 19465939 17604944 25447917 20179234
PAK1 PXN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 26598620 10330411 11096073 16717130 14580336 18986306 27542844 28214467 25472536 17440071 23317503
PAK1 ACTR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16293614 10467124 14749719 9843499 16702231 10511705 12054568 8625410
PAK1 ARHGEF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 22072711 17488622 14970201 19667072 19690332 29036929 24352660 28096473 20406887 18669648
PRKACA PPP1R9B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 12417592 16300646 18669648 20068231
SIRT6 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19408108 19135889
ESR1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 20080630 16115928 22787161 12750288 20696891 17681750 17699779
RELA TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 18269916 10348347 11032029 8051093 20061391 15155458 21332394 9890939 21887328
TP53 IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 15131018 11001824 12089352 20633551 24205274 17097318 10023442 17600529 17014845 8710868 12444079 16181796 22033326
TP53 CHUK â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15469934 11557753 17434128
TP53 MMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 18980971 22451655 23048035 10029407 9343394 19853299 11792711 19939245 17088079 17258390
TP53 PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 10321841 7915517 15358233 12217864 10516009 1705714 8570655 16980608 9707425 15950182 19789303 11313928 1356162 12384701 9858527 12947108 23390122 8524244 9651310 1352831 7909518 11032828 10910968 12485898 10618724
TP53 FGFR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22466965 18811981 16557594 24492005
TP53 PDGFRB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19952113 19763735 18697203
TP53 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12485897 18661553 19763735
TP53 FLT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16432214 20080630 17242190 20422012
TP53 MAPK8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 22607268 23376463 18374905 15958553 10854211 22353755
DYRK2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 111.0 1.0 Omnipath 29296831 21383696 14749479 11740489 20171273 25778922 15843377 33906076 10581258 15750624 15897882 15706352 26236013 24899407 33572115 17906639 20935676 24379358 17386256 15870257 26346493 12427754 34103685 17567906 11101524 17210684 18536714 15381073 19965871 26578795 26087959 28060750 21765464 20673369 34216619 16601678 17380123 33443163 18216278 21642861 15526030 22878263 17349959 16738336 20696760 19882354 16219768 17105820 16793543 17332358 24901999 16247456 24196445 26804244 15657359 27208501 18056705 21765463 23420876 22797063 16377624 19861417 18160537 12676607 20123963 15489221 17591690 20514025 23149944 19857493 17891183 27034505 11780126 21057547 25944899 26341817 17349958 20962272 22525275 19828042 12902982 19465479 15471885 15322239 11495913 12907596 32083004 25915850 20018442 24145406 26029824 21394211 12093737 33872315 20610713 20024960 26113041 20811699 18560558 21660965 16717128 11030628 17107963
MAPK8 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 11108663 12531896 16713569 11283254 10706102 19651615 27147566 9724739 15538975 9732264 10581258 10436023 17570479 9393873 11896587 12514174 15580310 18813780 11078726
MAPK11 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 15187187 17145710 19436832 15140942 10212189 20506250 21614932 16393692 17254968 11274345
ACTB RHOA â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 12805219 18001770 12732141 12429848 18923426
PFN1 ACTB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 17541406 8413665 563468 10600384 10411937 10592173 19000816 16189514 19338310 9463375
MAP3K7 PRKAA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16054096 16054095 15509864 19197243 17244528 18692468 15980064
PRKAA2 VASP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17082196 21945940
CRKL FLT4 â—¼   PHYSICAL_INTERACTION 56.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11335727 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15308668 15501236 15520864 15567848 15573129 15574420 16000375 16002046 16076871 16530705 16572188 16582911 16887996 17086423 17496910 17673906 17883421 18835194 19414323 19449109 19454690 21372296 22064427 22461508 22464172 23390297 24217602 24346288 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
CRKL KDR â—¼   PHYSICAL_INTERACTION 34.0 1.0 ACSN 10022831 11166270 11960372 12629515 13678960 15099563 15111329 15308668 15501236 15520864 15573129 16000375 16002046 16076871 16530705 16572188 17086423 17883421 18835194 19414323 19454690 21372296 22064427 22461508 22464172 23390297 24217602 24346288 25922287 26201938 8837607 9157999 9570538 9753319
CRKL KDR â—¼   SHARES_COMPLEX 34.0 1.0 ACSN 10022831 11166270 11960372 12629515 13678960 15099563 15111329 15308668 15501236 15520864 15573129 16000375 16002046 16076871 16530705 16572188 17086423 17883421 18835194 19414323 19454690 21372296 22064427 22461508 22464172 23390297 24217602 24346288 25922287 26201938 8837607 9157999 9570538 9753319
CRKL FLT4 â—¼   SHARES_COMPLEX 56.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11335727 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15308668 15501236 15520864 15567848 15573129 15574420 16000375 16002046 16076871 16530705 16572188 16582911 16887996 17086423 17496910 17673906 17883421 18835194 19414323 19449109 19454690 21372296 22064427 22461508 22464172 23390297 24217602 24346288 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
CRKL FLT4 â—¼   ENZYMATIC_REACTION ✅ 56.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11335727 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15308668 15501236 15520864 15567848 15573129 15574420 16000375 16002046 16076871 16530705 16572188 16582911 16887996 17086423 17496910 17673906 17883421 18835194 19414323 19449109 19454690 21372296 22064427 22461508 22464172 23390297 24217602 24346288 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
CRKL RAP1A â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 11353765 15169881 15308668 16000375 16076871 18835194 19454690 20189481 22464172
CRKL PXN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 8978305 7493940 9710592 10592173 11463817
RAC1 ACTG1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 18391171 16262445 11231582 9600938 15040784 12743368
RHOA ACTG1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 12805219 18001770 12732141 12429848 18923426
PDGFB PDGFRB â—¼   PHYSICAL_INTERACTION 5.0 1.0 ACSN 15099563 17145802 17496910 18633355 24359404
PDGFB PDGFRB â—¼   SHARES_COMPLEX 5.0 1.0 ACSN 15099563 17145802 17496910 18633355 24359404
PDGFB PDGFRB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 9739761 20577048 30150707 16189514 15207812 28267575 7679113 11297552 15207811 20534510 17981115 10806482 285049611903042 11903042 11331882 2850496
PDGFRB PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 34.0 1.0 Omnipath 17081983 7486683 2472219 16126727 15592455 7535778 16713569 23331499 1689310 11896612 15641795 16153436 16038803 23063561 1708307 7682059 15144186 12601080 1396585 8885868 8657103 8443409 23397142 15212693
KDR FLT4 â—¼   PHYSICAL_INTERACTION 34.0 1.0 ACSN 10022831 11166270 11960372 12629515 13678960 15099563 15111329 15308668 15501236 15520864 15573129 16000375 16002046 16076871 16530705 16572188 17086423 17883421 18835194 19414323 19454690 21372296 22064427 22461508 22464172 23390297 24217602 24346288 25922287 26201938 8837607 9157999 9570538 9753319
KDR FLT4 â—¼   SHARES_COMPLEX 34.0 1.0 ACSN 10022831 11166270 11960372 12629515 13678960 15099563 15111329 15308668 15501236 15520864 15573129 16000375 16002046 16076871 16530705 16572188 17086423 17883421 18835194 19414323 19454690 21372296 22064427 22461508 22464172 23390297 24217602 24346288 25922287 26201938 8837607 9157999 9570538 9753319
KDR PLCG1 â—¼   ENZYMATIC_REACTION ✅ 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
ESR1 KDR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16574784 18006642
KDR PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15212693 16835467 12598525 10672011
ACTR3 ARPC2 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR3 ARPC4 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR3 ARPC4 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR3 ARPC2 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ARPC2 ARPC4 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ARPC2 ARPC4 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
FLT1 PLCG1 â—¼   ENZYMATIC_REACTION ✅ 27.0 1.0 ACSN 10022831 11166270 11960372 12629515 13678960 15099563 15111329 15501236 15520864 15573129 16002046 16076871 16572188 17086423 19414323 21372296 22064427 22461508 23390297 24217602 24346288 25922287 26201938 8837607 9157999 9570538 9753319
FLT1 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 9299537 23331499 9398617 9600074 11312102 18988627 23397142
ERBB2 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 16273093 1676673 1683701
PRKACA PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 1370476 2479646
ALK PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17145710 11888936 23331499 14968112 9174053
AXL PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9178760
RHOA PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 12071848
FGFR1 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 17081983 20932831 1656221 16126727 15592455 9660748 19665973 7991458 1689310 8321198 8050374 16153436 17496910 25241761 16038803 10459043 23063561 1708307 7682059 15144186 12601080 9052794 8885868 8657103 15212693
MAPK8 PXN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 20068231 18713649 12853963 23890137
MAP3K7 TAB3 â—¼   PHYSICAL_INTERACTION 25.0 1.0 ACSN 10391247 11280761 11460167 11477091 12620219 14633987 14660645 15082531 15125833 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20164171 21041997 21133840 21232017 22941947 23681101 24403530 24699077 24958845
MAP3K7 TAB3 â—¼   SHARES_COMPLEX 25.0 1.0 ACSN 10391247 11280761 11460167 11477091 12620219 14633987 14660645 15082531 15125833 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20164171 21041997 21133840 21232017 22941947 23681101 24403530 24699077 24958845
CHUK MAP3K7 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 20300203 9744859 17047224 11460167 17496917 14514672
IRAK1 MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12242293 17197697
TAB3 MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 17145710 21903422 14633987 14743216 17158449 17384642 14670075 22081109
PPP6C MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 17079228
MAP3K7 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 17145710 14960582 16893890 15836773 33895773 12547194 25241761 24911653 2547194 9742107 18949366 11274345 20200282 20194509 10094049 18855897 10187861
MAP3K7 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15692051 17947236 11865055 17965022 17186025
MAP3K7 KSR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11741534 12941695
MAP3K7 MAP3K14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17145710 10094049
IRAK4 IRAK1 â—¼   PHYSICAL_INTERACTION 30.0 1.0 ACSN 10679398 11274345 11592085 12620219 12682231 12738796 14504095 14660645 14662834 15099563 15125833 15802534 16252010 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 23070005 23681101 23811849 26885855 27048821 27066895 9469432
IRAK4 TIRAP â—¼   PHYSICAL_INTERACTION 25.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
IRAK4 TIRAP â—¼   SHARES_COMPLEX 25.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
IRAK4 IRAK1 â—¼   SHARES_COMPLEX 30.0 1.0 ACSN 10679398 11274345 11592085 12620219 12682231 12738796 14504095 14660645 14662834 15099563 15125833 15802534 16252010 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 23070005 23681101 23811849 26885855 27048821 27066895 9469432
IRAK4 IRAK1 â—¼   ENZYMATIC_REACTION ✅ 30.0 1.0 ACSN 10679398 11274345 11592085 12620219 12682231 12738796 14504095 14660645 14662834 15099563 15125833 15802534 16252010 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 23070005 23681101 23811849 26885855 27048821 27066895 9469432
IRAK4 FLT3 â—¼   DOWN_REGULATES ✅ - 25.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
IRAK4 IRAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 17145710 17785851 18252867 17276401 16024789 14625308 15084582 21903422 15292196 25452754 19775907 18221795 15905496 19166926 12538665 12860405 14751757 12496252 11960013 24735611 26143580 17337443
RBCK1 SHARPIN â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 11280761 11460167 14660645 17301840 18264787 21133840 21232017 24699077 24958845
RBCK1 SHARPIN â—¼   SHARES_COMPLEX 9.0 1.0 ACSN 11280761 11460167 14660645 17301840 18264787 21133840 21232017 24699077 24958845
RELA CCL5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 12820969 11478739 17510282 19786024 12050170 21138578 12122011 19828633 18367595 22030901 18502824 16707500 10926836 11413310 20663893 22388040 15144466 9120310 12603855 26096887 11259372 21189258 12388374 15972972 11389171 25523420 18525004
CYBA RAC1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 16636067 18347018 12716910 16329988 16762923
ITGA2B RAP1A â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 14754902 8755247 11940607 17218263 18434644 10964917 10446041
ITGB3 RAP1A â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 14754902 8755247 11940607 17218263 18434644 10964917 10446041
PRKACA RAP1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 8463283 9867809
RAPGEF2 RAP1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10608883 10934204 10608844
RAP1A AFDN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10922060 10224125
RELA CUL1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9990852 10514433 9859996 9990853 7628694
CUL1 MAP3K14 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9346238 15340381 16303288 8706131
AKT1 CUL1 â—¼   ENZYMATIC_REACTION ✅ 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
AKT1 CUL1 â—¼   DOWN_REGULATES ✅ - 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
CHUK FBXW11 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9346238 15340381 16303288 8706131
CHUK RELA â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 9315679 9914500 9721103 10593898 9135156
AKT2 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 19609947 12048203 10485710
AKT1 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 15710601 12048203 25241761 19442713 11278366 10485711 15800029 19609947 17570479 17660512 18515365 19088076 10485710
MAP3K14 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 69.0 1.0 Omnipath 17145710 11278268 16498412 30833792 23915189 9346485 11520989 10072079 17563756 18515365 10887201 16223731 12556537 16286467 14743216 9244310 20348096 10094049 15140882 15208311 20685151 25241761 9742107 10229185 9520446 15084608 15994789 10713178 9819420 17150968 11239468 16691505 26948423 20651737 9020361
CHUK H3-4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12789342 2789342
CHUK RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 49.0 1.0 Omnipath 17145710 15611276 22110409 19609947 10521409 20863851 20051109 20363318 12767944 26999213 12842894 21903422 19110719 15858576 16382138 22155370 23894194 16046471 15128824 21569639 16846590 8246997 15485852 25341660 15494311 11983155 15980040 15489227 15849198 14636585 23343355
RELA FBXW11 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 10321728 9990852 10066435 9859996 10514424 10230406
RPS6KA5 RELA â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17462920 12628924 19197368 19122653 18385332
PRKACA RELA â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17462920 12628924 19197368 19122653 18385332
RELA AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20186924 18031796 20649564
RELA IFNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 23932714 15955070 22547704 19570999 10074115 21209118 17079305 7799921 17496231 15699120 12077266 8035474 17785777 12005436 24185615 10848607 16125763 9446577 20855868 24656046 23857586
RPS6KA5 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 17145710 27768872 19197368 22187158 20204068 22216091 19706715 30240634 25241761 11931769 19910110 21791059 23536830 23485395 22312446 19789307 24705157 27009097 17255956 12628924
PRKACA RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 11931769 15833743 9150141 17959673 9660950 16135789 12628924
TIRAP IRAK1 â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
TIRAP FLT3 â—¼   DOWN_REGULATES ✅ - 25.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
IGF1R MAP3K5 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10086337 10826997 11274345 12175651 12444011 12556535 12655147 12767520 16931767 17145802 17673906 19030972 21540285 24103846 24782617
YWHAQ MAP3K5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17145710 15023544 17389591 19880523
AKT2 MAP3K5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 14500571 23603750 12697749 11154276 27363949
AKT1 MAP3K5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 16532036 14500571 11154276 30677014 17184578
MAP3K5 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 50.0 1.0 Omnipath 17634293 20348951 15247305 21785467 12194869 12221076 18818208 18029441 19667122 21726807 16760468 21212517 19749799 26147002 25310587 33573023 26375285 16648474 15944157 7839144 12456653 25915038 26853469 21856198 31575661 10521505 25702873 19029119 20156337 16928747 15020250 20452983 15242986 18570871 16845370 20871632 21040800 27203743 19783996 21931634 23608534 21697492 25619840 26964622 12758252 16632641 28881794 17210579 34048499 20921231
RAC1 NOX1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 16636067 18347018 12716910 16329988 16762923
RAC1 AKT1 â—¼   ENZYMATIC_REACTION ✅ 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
ARHGEF2 RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11595749 16189514 9857026
RAC1 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17251915 12213839 18423204 18426980 10592173 22252525 10930450
RAC1 PAK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 9744077 10023776 8805275 16212495 12480336 11152757 25301945 11728826 11478794 8910277
RAC1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 34.0 1.0 Omnipath 18000759 20027184 21157483 11756412 11923280 16697215 20398329 17461779 18372248 20338997 15808505 20138985 20214616 21474067 19568798 15169778 19720745 18925875 10949026 11715018 19143635 12393431 18636226 10617634 9812896 17680028 19151919 10722653 20832730 18570873 17052453 12408816 11274345
IGF1R YWHAB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 12767520 10826997 12444011 21540285 15629149 17353931 19030972 14651979 17145710 16931767 9581554 12175651
AKT1 YWHAB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 20138985 15169778 9812896 17680028 11756412 11923280 20214616 16697215 10949026 10722653 20832730 18570873 18372248 11715018 20398329 17052453 18636226 15808505
MAPK8 YWHAB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 7890696 15696159 15071501
YWHAB YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17085597 12657644 12426317 15071501
ROCK2 RHOA â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11283606 15699075 8816443 11294240 8617235
PRKACA RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 12654918 21572420 20591975 8599934 16109481 34088899 11162591 15890975
ARHGEF1 RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9789025 12748184 32203420 9113980 9641915 10836144 11149925
ARHGEF2 RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 9789025 22072711 32203420 9113980 9641915 10592173 9857026 20810787 16189514 24525234 11149925
ARHGEF18 RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11085924 20810787 18256687
ARHGEF11 RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17145710 21988832 32203420 20300064 15530360 10526156
ARHGEF12 RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 9789025 17145710 15364580 23405219 32203420 9113980 9641915 20300064 10592173 11373293 12515866 11094164 11149925
ARHGAP1 RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 32203420 9535855 9548756 9407060 11927263 31467278 16189514 20660160 14749388
RHOA ROCK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23109003 12727213 17673200 17446864 11350930
RHOA PKN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 8571127 12773565 16189514 9446575 10619026 9535835
RHOA MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15659383 25241761 8824197
ESR1 IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17170218 20021813 16087727 19250214 10982795 24281069 18414489 15595626
IGF1R YWHAZ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12767520 10826997 12444011 21540285 19030972 16931767 9581554 12175651
IGF1R PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17496910 25241761 9415396 9524259
AKT1 MMP2 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 17409395 17680028 18471976 19440036 19930715 19945467 20214616 20398329 20609352 21084277 22131018 23572150 23589069 24030100 25136802 26597054 27328425 27510662 27572739 29556339
AKT1 RRAGB â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17517883 17277771 18372248 12524439 17386266
AKT1 RRAGD â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17517883 17277771 18372248 12524439 17386266
ESR1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11029009 15569929 18450422 20664923 15496458
PPP2R2A AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 18039929 19216069 18077353 19556239 19996169 10026142 10995457 18042541 20452955 18559511 18588945 16680151 20360384 16406523
PPP2R5B AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 18039929 19216069 10026142 10995457 18042541 20452955 18559511 18588945 16680151 16495456 16406523
AKT1 BMI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22505453 23092893
AKT1 ITGB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 18578522 10896934
AKT1 IRAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 11976320
AKT1 PRKACA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 20016067 23331499 17680028 20214616 17688959 20398329 16537363 17052453 19575820
AKT1 AKT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11546794 14500673 12176337 11445557 9736715 12149249 11278835
AKT1 YWHAZ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 11756412 9705322 11923280 16697215 20398329 18372248 12865427 15071501 15808505 20138985 20214616 15883165 15169778 10949026 12861023 11715018 18636226 9812896 17680028 11956222 10722653 20832730 18570873 16376338 17052453
AKT1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 18521086 26944939 11108261 17627277 20101208 17570479 15604293 23169992 26554417 16452229 15193262 7838153 12374744 11139588 26272591 11432835 20179234 11507039 9528769
AKT1 YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 20138985 15169778 9812896 17680028 11756412 11923280 20214616 16697215 10949026 10722653 20832730 18570873 18372248 11715018 20398329 17052453 18636226 15808505
AKT1 YWHAH â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 20138985 15169778 9812896 17680028 11756412 11923280 20214616 16697215 10949026 10722653 20832730 18570873 18372248 11715018 20398329 17052453 18636226 15808505
AKT1 AKT1S1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 63.0 1.0 Omnipath 18000759 17081983 17510057 12820960 21157483 11756412 11923280 16697215 19690332 19446321 20398329 17461779 18372248 19413330 15808505 20138985 23415227 20214616 12524439 20068231 14973226 19568798 18669648 17329361 15169778 12869586 17386266 19720745 17517883 11352916 10949026 11715018 19143635 17277771 18636226 19651622 9812896 17680028 19151919 10722653 20832730 18570873 17052453 12408816 11274345
PRKACA CFTR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 28003367 23060444 25867080 21455600 30600261 1716180 28242698 19328185 32102849 92316961 19095655 14602047 7530719 10581361 11053017 9385646 25330774 15657296 1377674
HSPA8 CFTR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 21148293 10666020 19878303 21697503
RHOB PKN1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 14514689 21351730 10619026 9988689 18006505 24128008
ARHGEF11 ERBB2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 12220504 15210733 12196628 12730235
ERBB2 ARHGEF12 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 12220504 15210733 12196628 12730235
AKT3 PRKACA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20016067 17680028 20214616 17688959 20398329 16537363 17052453 19575820
PRKACA ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 22266331 9891036 15193262
PRKACA VASP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 8182057 20058876 20166139 14679200 7925440 8836115 94237860 16197368 10851246 9685341 17287340 10922374 12576312
PRKACA YWHAZ â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 29109150 11956222 12861023 16376338 19451227
PRKACA ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18799465 9855018
ERBB2 DOCK7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18426980 27018747
MAPK11 RPS6KA5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 15187187 19436832 23331499 15140942 21071413 20506250 21614932 16393692 9687510 11274345
ESR1 ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 24559156 16115928 16467118 17992604 19915977 15199112 21127199 21761336 21907803 20551150 11713584 1358436 20629094 18768663 19005469 9242384 20889718 10698518 16467117
ERBB2 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 15173068
ESR1 CAV2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12711000 12138116 18414489
AKT2 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 11139588 11432835 11507039 9528769 7838153
MAP3K14 FBXW11 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9346238 15340381 16303288 8706131
AKT2 AKT1S1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 17329361 19651622 17081983 17386266 17517883 12524439 11352916 20068231 18372248 19413330 17277771 14973226 18669648 23682635
AKT3 AKT1S1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17440074 17517883 18372248 17277771
MAPK8 YWHAZ â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 18985696 25862939 15696159 11956222 19788416 21081103 15071501 18559254 7890696
YWHAH YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21827211 12657644 12426317 15071501
PIK3R3 PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 8596638 22402981 11733063 25814554
BMPR2 ACVR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 21071413 16446785 7791754 7890683
BMPR2 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18756288 7791754 10712517
ROCK2 RHOB â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11283606 15699075 8816443 11294240 8617235
YWHAZ YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21827211 12657644 12426317 15071501