FOXO1
|
CASP3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19050291
15565601
|
CASP3
|
AKT1
|
â—¼ CLEAVAGE
|
✅
|
|
2.0
|
0.8
|
intact
|
17544405
5219985
|
CASP3
|
PIP5K1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11042212
|
CCND1
|
AR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16461912
0506281103
|
NCOA2
|
CCND1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
21505052
22581837
|
EGFR
|
CCND1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
7945309
|
EGFR
|
KPNA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
20692258
7987951
|
EGFR
|
NRAS
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
23220880
22908275
|
EGFR
|
H3C2
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
5216105
12577067
|
EGFR
|
PIK3CA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17496910
1845983
|
FOXO1
|
INS
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
22968147
21335550
|
FOXO1
|
PCK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11467835
|
TRAF2
|
IKBKE
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
HSP90AB1
|
IKBKE
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
TUBB
|
IKBKE
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
KRT19
|
KDM1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
23455924
8417751
|
BAIAP2
|
KDM1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
23455924
8417751
|
MYC
|
KDM1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
23455924
8417751
|
BLZF1
|
KDM1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
23455924
8417751
|
KDM1A
|
SSX2IP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
23455924
8417751
|
KDM1A
|
STX11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
23455924
8417751
|
SNAI1
|
KDM1A
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
7903691
20389281
|
MAPK14
|
MAP2K6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17255949
5219578
|
MAP2K6
|
MAPK14
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
8622669
7535770
|
MAP2K6
|
MAPK11
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
8622669
7535770
|
MAP2K6
|
MAPK8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11460167
10882101
|
MAP2K3
|
MAPK14
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
8622669
7535770
|
MAPK11
|
MAPK14
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23602568
21900206
|
MAPK14
|
MAPT
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20626350
15632108
|
RAF1
|
MAPK3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
20674547
15664191
|
MAPK3
|
MAPT
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19046355
9614189
|
MAPT
|
AKT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
0709180105
18292230
|
MTOR
|
PDPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5214238
11438723
|
MTOR
|
TRAF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
MTOR
|
AKT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5214238
11438723
|
AKT1
|
MTOR
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
17611497
18954143
|
MTOR
|
EIF3F
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16541103
|
MYC
|
PIK3R1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19602047
11509615
|
MYC
|
HSP90AB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11983916
|
MYC
|
PDGFRB
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
15226411
18697203
|
MYC
|
INS
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11799123
1917937
|
MYC
|
IGF2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
16707459
15355996
|
AKT1
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
17942906
9804616
|
EPO
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
11598010
12506011
|
MAPK8
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
7033842
16982329
|
PIK3R1
|
IGF1R
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.8
|
0.8
|
mint
|
6730400
7589433
|
AR
|
PIK3R1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12933816
|
PIK3R1
|
MAPK8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
7642542
16982329
|
TRAF2
|
RUVBL2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
H3C2
|
SNAI1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
7903691
20389281
|
TUBB
|
TNFRSF1B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
VIM
|
TNFRSF1B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
AR
|
TNFRSF1B
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
7476976
20610535
|
MAP3K20
|
MAP2K3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23331499
11836244
|
NEFL
|
KRT19
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
USHBP1
|
KRT19
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16189514
5217968
|
KRT19
|
KRT15
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16189514
5217968
|
EIF3F
|
FBXO32
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
6613251
18354498
|
USHBP1
|
SERTAD3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16189514
5217968
|
SERTAD3
|
USHBP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16189514
5217968
|
JUN
|
KRT16
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12954631
16214953
|
VIM
|
NEFL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
15383276
5217202
|
DCTN3
|
ACTR10
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
15473859
15738427
|
PDGFRB
|
PIK3CA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17496910
8702949
|
HSP90AB1
|
TRAF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
TUBB
|
TRAF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
RAF1
|
AKT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
19197339
7014125
|
KIT
|
PIK3CA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17496910
7520444
|
JUN
|
MAPK8
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
18793328
10871633
|
JUN
|
AKT1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12832543
11192249
|
JUN
|
MBP
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
20720108
11226757
|
JUN
|
KRT15
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16415016
22761689
|
AR
|
NGF
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20610535
15135217
|
PDPK1
|
IKBKB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
29312296
16207722
|
PDPK1
|
YWHAH
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12177059
|
PKN1
|
AKT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
1218925110
23223530
|
AKT1
|
PHLPP2
|
â—¼ DEPHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
17386267
15808505
|
MAPK8
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16306447
|
FGFR2
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
15863030
11353842
|
TUBB
|
IKBKB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
HSP90AB1
|
IKBKB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
TUBB
|
TRAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
TRAF1
|
GOLGA2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
20156660
27107012
|
IKZF3
|
GOLGA2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
20156660
27107012
|
GOLGA2
|
IKZF3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
20156660
27107012
|
AKAP9
|
GOLGA2
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
7234073
19242490
|
GNG2
|
PIK3CA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17419683
16537363
|
CCND3
|
CCNE1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16609025
|
EPO
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
11598010
12506011
|
EPOR
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
11598010
12506011
|
PIK3CA
|
FGF23
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
15863030
11353842
|
MAP2K3
|
MAPK11
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
8622669
7535770
|
HSP90AB1
|
AR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
21730179
1105160108
|
NCOA2
|
AR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
12588987
5216126
|
AR
|
YWHAH
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
19996220
8009645
|
AR
|
SMYD3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20610535
24174655
|
AR
|
MBP
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20610535
7657701
|
NCOA2
|
H3C2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18022353
|
NCOA2
|
H4C6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18022353
|
DCTN3
|
DCTN5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
15473859
15738427
|
MEFV
|
CASP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16785446
0602081103
|
EPOR
|
EPO
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
29997244
20178071
|
USHBP1
|
KRT15
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16189514
5217968
|
H3C14
|
H3-3B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
000924
30021884
|
DYDC1
|
USHBP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16189514
5217968
|
EGFR
|
TUBA1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
801.0
|
0.8
|
STRING
|
36370105
|
ASH2L
|
HIST2H3C
|
â—¼ PHYSICAL_INTERACTION
|
|
|
803.0
|
0.8
|
STRING
|
36370105
|
IGF1R
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
806.0
|
0.8
|
STRING
|
36370105
|
PIK3R1
|
EGFR
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.81
|
0.81
|
mint
|
16273093
5218056
|
HIST2H3C
|
RBBP5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
812.0
|
0.81
|
STRING
|
36370105
|
EGFR
|
IGF1R
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
17047074
17307140
|
MYC
|
JUN
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
21150319
20232342
|
CASP5
|
CASP4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
AKT1
|
HSP90AB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
820.0
|
0.82
|
STRING
|
36370105
|
TRAF2
|
MTOR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
14743216
25241761
|
HIST2H3C
|
KMT2A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
829.0
|
0.83
|
STRING
|
36370105
|
AKT1
|
MAPK14
|
â—¼ PHYSICAL_INTERACTION
|
|
|
830.0
|
0.83
|
STRING
|
36370105
|
ACTR10
|
DCTN3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
834.0
|
0.83
|
STRING
|
36370105
|
IGF1R
|
IGF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
835.0
|
0.83
|
STRING
|
36370105
|
IGF1R
|
INS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
835.0
|
0.83
|
STRING
|
36370105
|
HIST2H3C
|
WDR5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
836.0
|
0.83
|
STRING
|
36370105
|
TUBA1A
|
TUBB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
837.0
|
0.83
|
STRING
|
36370105
|
EIF3F
|
MTOR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
32131492
16541103
|
MYC
|
CDR2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
10465786
20383333
|
AR
|
CCND1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
840.0
|
0.84
|
STRING
|
36370105
|
PARK2
|
TRAF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
845.0
|
0.84
|
STRING
|
36370105
|
MAPK8
|
JUN
|
â—¼ PHOSPHORYLATION
|
✅
|
|
0.85
|
0.85
|
mint
|
7148309
19527717
|
AKT1
|
FOXO1
|
â—¼ PHOSPHORYLATION
|
✅
|
-
|
0.85
|
0.85
|
Signor
|
21798082
|
AKT1
|
FOXO1
|
â—¼ RELOCALIZATION
|
✅
|
-
|
0.85
|
0.85
|
Signor
|
18423396
|
PKN1
|
TRAF2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
32296183
14741690
|
EGFR
|
RAF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
24658140
25402006
31980649
|
MYC
|
KDM1A
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
32296183
30415952
29467282
23455924
|
MYC
|
WDR5
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
17353931
27320920
35140242
29467282
31767764
30415952
|
WDR5
|
PDPK1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
28514442
33961781
26186194
27705803
|
KDM1A
|
SNAI1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
870.0
|
0.87
|
STRING
|
36370105
|
AKT1
|
AR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
870.0
|
0.87
|
STRING
|
36370105
|
NRAS
|
RAF1
|
â—¼ RELOCALIZATION
|
✅
|
+
|
0.87
|
0.87
|
Signor
|
21779497
|
HSP90AB1
|
MAPT
|
â—¼ PHYSICAL_INTERACTION
|
|
|
875.0
|
0.87
|
STRING
|
36370105
|
CDC25C
|
YWHAH
|
â—¼ PHYSICAL_INTERACTION
|
|
|
877.0
|
0.87
|
STRING
|
36370105
|
IKBKB
|
TRAF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
878.0
|
0.87
|
STRING
|
36370105
|
AKT1
|
PDK1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
27166089
27505672
34278744
|
PKN1
|
ACTN1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
9030526
16189514
16713569
11802708
|
GBP1
|
GBP2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
28514442
21151871
33961781
|
AKT1
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
880.0
|
0.88
|
STRING
|
36370105
|
AKT1
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
880.0
|
0.88
|
STRING
|
36370105
|
TNFRSF1B
|
TRAF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
881.0
|
0.88
|
STRING
|
36370105
|
INS
|
IGF1R
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
+
|
0.88
|
0.88
|
Signor
|
1851182
|
KRT34
|
MKRN3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.88
|
0.88
|
HuRI
|
32296183
|
RAF1
|
YWHAH
|
â—¼ PHYSICAL_INTERACTION
|
|
|
888.0
|
0.88
|
STRING
|
36370105
|
EGFR
|
AKT1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
24658140
25402006
31980649
|
AKT1
|
FOXO1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
889.0
|
0.89
|
STRING
|
36370105
|
KIT
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
889.0
|
0.89
|
STRING
|
36370105
|
PDPK1
|
PKN1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
10792047
10764742
16189514
10753910
|
PKN1
|
AKAP9
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
32296183
10358086
|
H3C2
|
H4C6
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.89
|
0.89
|
mint
|
7219095
19498464
|
EGFR
|
HSP90AB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
890.0
|
0.89
|
STRING
|
36370105
|
EGFR
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
893.0
|
0.89
|
STRING
|
36370105
|
ASH2L
|
WDR5
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
28514442
31544921
17925232
16253997
20305087
21285357
15960975
21531708
15199122
17178841
25666610
16892064
15960974
18066051
23870121
23508102
21884981
32076268
33022573
22939629
16878130
31076518
27705803
19556245
17500065
19131338
33961781
24981860
16603732
26186194
|
ASH2L
|
RBBP5
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
25416956
31544921
17925232
12482968
16253997
21124902
20305087
21516116
21285357
32296183
21220120
15199122
17178841
16892064
15960974
23870121
23508102
26886794
16878130
31076518
17500065
19556245
19131338
33961781
24981860
16603732
23414517
34079125
|
BAK1
|
TRAF2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
ACSN
|
22039431
23430059
23850759
|
AR
|
CASP3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
22038727
20610535
23554843
|
FOXO1
|
CCND1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
22266855
12391153
|
EGFR
|
TRAF2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
31980649
24658140
23972990
25402006
18271526
|
PKN1
|
EGFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
21749319
|
FOXO1
|
PCK2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
10385407
|
PKN1
|
FOXO1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
12560069
|
SNAI1
|
KDM1A
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
25639869
20562920
23011797
33961781
26186194
20389281
21300290
|
AR
|
KDM1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
20610535
16079795
22052438
|
MAPK11
|
MAPK14
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
PKN1
|
MAPK14
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
17145710
17251915
12761180
|
MAPK14
|
H3-3B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
11278789
10806218
12917630
|
MAPK3
|
BAIAP2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
17202194
15657136
21419341
|
MAP2K3
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
8226933
|
MTOR
|
AKT1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
25241761
18566587
25792870
15718470
14970221
24670654
10910062
18505677
29567957
22337773
21177249
26293922
19299511
18566586
30639242
21045808
11438723
22084251
23872070
21343617
22307628
|
MYC
|
RAF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
17314511
9315742
28628118
28205554
|
MYC
|
FGFR4
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12695333
|
MYC
|
AKT1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
16846534
16489011
18562319
|
MYC
|
NRAS
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12695333
|
MYC
|
EIF4B
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12747840
|
MYC
|
CDC25C
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12747840
22446629
|
PKN1
|
PGM1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
15378030
|
AR
|
PIK3R1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
22740037
12063252
20610535
|
SNAI1
|
VIM
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
12632084
19538137
17273560
|
PKN1
|
SNAI1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
15833848
|
PKN1
|
PGAM1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
12189148
|
PKN1
|
VIM
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
9175763
16713569
|
PDGFRB
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
2466336
1374684
9739761
|
TRAF1
|
TRAF2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
28514442
10544141
25241761
20385093
14557256
21903422
14743216
32296183
29748372
11181075
15383523
8702708
8069916
19287455
16713569
9718306
25996949
9500555
33961781
|
AKT1
|
RAF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
16189514
25241761
28628118
10576742
19197339
19058874
28205554
|
IKBKB
|
NGF
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
8837778
11244088
8599092
|
PDPK1
|
AKT1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
16189514
9368760
11825911
14500673
10698680
31467278
12149249
27563096
11313365
11278835
22569334
26264872
10226025
32876514
26256536
21775285
11438723
11445557
23397142
|
MTCP1
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
10983986
16189514
11707444
|
PKN1
|
ARHGEF2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
14970201
|
PKN1
|
MAP2K3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
11238375
17145710
12761180
|
AR
|
MID1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
24913494
20610535
|
CASP4
|
CASP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12843244
9491891
9039262
|
EPOR
|
EPO
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
28514442
9030560
29997244
9808045
17327410
9774108
26481148
15358619
10318834
8662939
|
EPO
|
EPOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
904.0
|
0.9
|
STRING
|
36370105
|
AKT1
|
MTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
905.0
|
0.9
|
STRING
|
36370105
|
ACTR10
|
KRT31
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.91
|
0.91
|
HuRI
|
32296183
|
YWHAH
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.92
|
0.92
|
mint
|
8005785
11697890
|
MAP2K6
|
MAPK14
|
â—¼ PHYSICAL_INTERACTION
|
|
|
922.0
|
0.92
|
STRING
|
36370105
|
MTOR
|
AKT1
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.92
|
0.92
|
Signor
|
21592956
|
PDGFRB
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
926.0
|
0.92
|
STRING
|
36370105
|
MAP2K3
|
MAPK14
|
â—¼ PHYSICAL_INTERACTION
|
|
|
928.0
|
0.92
|
STRING
|
36370105
|
NRAS
|
RAF1
|
â—¼ PROXIMITY
|
✅
|
|
0.93
|
0.93
|
mint
|
30194290
|
AKT1
|
PDPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
937.0
|
0.93
|
STRING
|
36370105
|
NRAS
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
945.0
|
0.94
|
STRING
|
36370105
|
AKT1
|
FOXO1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.95
|
0.95
|
HIPPIE
|
10358075
25241761
10358014
16076959
31844113
18786403
|
PIK3R1
|
PDGFRB
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.95
|
0.95
|
mint
|
7536927
6730373
|
WDR5
|
KMT2A
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.95
|
0.95
|
mint
|
24981860
|
PIK3R1
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.97
|
0.97
|
mint
|
20018188
7383613
|
AR
|
NCOA2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
977.0
|
0.97
|
STRING
|
36370105
|
ASH2L
|
KMT2A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
985.0
|
0.98
|
STRING
|
36370105
|
KMT2A
|
RBBP5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
985.0
|
0.98
|
STRING
|
36370105
|
KMT2A
|
WDR5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
985.0
|
0.98
|
STRING
|
36370105
|
ACTR10
|
DCTN5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
987.0
|
0.98
|
STRING
|
36370105
|
TRAF1
|
TRAF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
987.0
|
0.98
|
STRING
|
36370105
|
RBBP5
|
WDR5
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.99
|
0.99
|
HIPPIE
|
28514442
31544921
17925232
16253997
20305087
15960975
30089852
21531708
21220120
15199122
17178841
25666610
31685992
15960974
27320920
23508102
21884981
32076268
33022573
16878130
28813667
17041588
31076518
17500065
19556245
27705803
24981860
33961781
16603732
26186194
31400120
|
GNB3
|
GNG5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
994.0
|
0.99
|
STRING
|
36370105
|
GNB3
|
GNG7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
994.0
|
0.99
|
STRING
|
36370105
|
RBBP5
|
WDR5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
996.0
|
0.99
|
STRING
|
36370105
|
JUN
|
MAPK8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
GNB3
|
GNG2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
ASH2L
|
RBBP5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
ACSN
|
11302744
12874027
17168535
19407509
|
ASH2L
|
WDR5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
ACSN
|
11302744
12874027
17168535
19407509
|
ASH2L
|
WDR5
|
â—¼ SHARES_COMPLEX
|
|
|
4.0
|
1.0
|
ACSN
|
11302744
12874027
17168535
19407509
|
ASH2L
|
RBBP5
|
â—¼ SHARES_COMPLEX
|
|
|
4.0
|
1.0
|
ACSN
|
11302744
12874027
17168535
19407509
|
MAPK14
|
CASP3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
8.0
|
1.0
|
Omnipath
|
14970175
33176141
29414778
|
CASP3
|
AR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
8626669
9535906
16713569
9208847
|
CASP3
|
MAPT
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
12888622
16606369
22535953
11162250
|
CASP3
|
VIM
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
8.0
|
1.0
|
Omnipath
|
11423904
10469173
11514563
|
CASP3
|
IKBKB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
9367996
11741536
|
CASP3
|
EIF4B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
11274152
10672017
|
CASP3
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
9.0
|
1.0
|
Omnipath
|
17544405
12124386
10579725
|
MYC
|
CCND1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
7526316
21933022
17881732
12835716
14757441
19086036
8552398
19698176
19786833
18809243
18806825
8196642
11085504
|
JUN
|
CCND1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
39.0
|
1.0
|
Omnipath
|
16393119
21135252
8917510
17166846
19622016
11402335
20220142
22853846
17670745
10567390
17496887
19499154
9878062
21474819
17278098
15282324
15467760
15994313
14672732
15574422
22550166
10066798
17637753
20482821
15574764
11745411
11410592
18084253
20037604
12794082
10790372
16860316
24190040
17501623
17477349
19435822
10500157
11432833
|
JUN
|
CCND1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
18813803
19219074
16406505
16880536
16054035
19190345
17000779
17439715
8545107
16396903
11274345
20107231
|
MYC
|
CCND1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
8425218
15121849
2006410
17873522
21406394
12584560
17558397
20551172
15814658
16908182
|
JUN
|
EGFR
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
16170369
23455325
15923621
16423552
10803405
18604200
|
AR
|
EGFR
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
11.0
|
1.0
|
Omnipath
|
15305378
19318561
21613411
19258514
15650253
17242169
18692155
15288768
11556855
20610535
|
MAPK3
|
EGFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
22.0
|
1.0
|
Omnipath
|
1651322
17081983
3138233
15901825
16785992
1939237
91332050
27531070
17570479
2543683
2115882
34086370
17192257
1651323
15302935
|
MAPK11
|
EGFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
15187187
18039929
12738796
16932740
11274345
|
MAPK14
|
EGFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
11.0
|
1.0
|
Omnipath
|
15187187
18039929
19138820
7535770
12738796
17139251
16932740
23397142
16785992
11274345
|
AR
|
EGFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
18358509
12534934
22260327
15288768
18951974
|
EGFR
|
PIK3R1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
23.0
|
1.0
|
Omnipath
|
17496910
26918608
7797556
25241761
19531499
16273093
8662998
14967450
16713569
21701776
|
AKT1
|
FOXO1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
15987244
10358075
10102273
12857750
|
FOXO1
|
IL7R
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
21532575
19285438
19136962
18978794
|
FOXO1
|
FBXO32
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
21798082
20079455
15109499
17540700
15125842
|
AR
|
FOXO1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
9.0
|
1.0
|
Omnipath
|
18391971
17202144
16713569
12482965
|
AKT1
|
FOXO1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
90.0
|
1.0
|
Omnipath
|
21440011
10358014
11756412
10358076
31308176
20452955
21798082
11410590
20398329
11311120
11544290
28279977
10217147
15132996
23331499
19216069
11237865
20214616
11463845
16076959
11030146
12228231
9829964
18951090
23180781
17570479
10102273
18593906
17646672
16680151
12456685
18423396
18985696
18988627
17962350
30728292
16670091
18786403
14664696
25241761
16341064
11980723
10358075
2984676
13679577
12560069
10377430
11251083
17680028
2987962
17254970
11864996
20041807
|
CD14
|
IKBKE
|
â—¼ PHYSICAL_INTERACTION
|
|
|
9.0
|
1.0
|
Reactome
|
12692549
15210742
14530355
17526488
17047224
14703513
19656901
17823124
23453971
|
KDM1A
|
H3-3B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17277772
24371278
19098913
18187655
|
KDM1A
|
H3C2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17277772
24371278
19098913
18187655
|
KDM1A
|
H4C6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17277772
24371278
19098913
18187655
|
KDM1A
|
H3C14
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17277772
24371278
19098913
18187655
|
KDM1A
|
H3C2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
16223729
20210320
18343668
20228790
15620353
|
KDM1A
|
AR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
17277772
16079795
|
TRAF2
|
MAP2K6
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
14.0
|
1.0
|
ACSN
|
11274345
12556535
12655147
12738796
15592525
17462996
18641653
18855897
19392652
21133840
21232017
21614932
23850759
24378531
|
TNFRSF1B
|
MAP2K6
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
14.0
|
1.0
|
ACSN
|
11274345
12556535
12655147
12738796
15592525
17462996
18641653
18855897
19392652
21133840
21232017
21614932
23850759
24378531
|
TRAF2
|
MAP2K6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
12655147
21614932
12738796
11274345
18855897
|
MAP3K20
|
MAP2K6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
23331499
11836244
14697338
11042189
|
PKN1
|
MAP2K6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
11238375
17145710
12761180
|
MAP2K6
|
MAPK12
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
22.0
|
1.0
|
Omnipath
|
23331499
10848581
11010976
11242034
11062067
21614932
12738796
11274345
11238375
19230643
19413330
18083107
18988627
9790884
18855897
|
MAP2K6
|
MAPK11
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
18291705
23331499
9362518
11242034
8622669
9430721
21614932
12738796
11274345
11727828
9790884
18855897
8621675
|
MAP2K6
|
MAPK14
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
96.0
|
1.0
|
Omnipath
|
10480932
19901323
17081983
7914033
9362518
18767875
17322306
8622669
18855897
16342939
16497976
15592455
8974401
7997261
15735649
18291705
23331499
8626699
21071413
16083285
21614932
18452278
12738796
20068231
9808624
11727828
16189514
18988627
17255949
9790884
16153436
18669648
26538579
14970210
16282370
11242034
18691976
18088087
11304531
15972258
10781613
17192257
18586681
10734320
20551513
19651622
15212693
7592586
16157584
21402774
9582275
15674326
9528766
7693711
12758252
11309380
7750576
17255097
17016520
15659558
11274345
15735648
|
MAP2K3
|
MAPK12
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
23331499
11242034
11062067
21614932
12738796
11274345
11238375
19413330
18083107
18855897
|
MAPK12
|
MAPT
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
76.0
|
1.0
|
Omnipath
|
9832145
19562805
12387894
9546672
19413330
15632108
1330687
19415658
15302935
9353289
9202310
20068231
9565682
11181841
7566346
12435421
17287340
9771888
17078951
19651622
9735171
10620503
11104762
12226093
9199504
18510355
|
MAP2K3
|
MAPK14
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
91.0
|
1.0
|
Omnipath
|
12589052
11279118
17081983
20213747
7914033
18767875
17322306
23602568
8622669
18855897
19690332
23904011
9162092
11426938
15592455
18083107
7997261
12384504
15735649
18291705
23331499
17389395
7535770
19534553
7839144
21071413
16083285
21614932
20068231
12738796
16189514
17255949
18669648
16153436
14970210
26186194
16407200
11242034
18691976
18088087
11304531
15972258
10781613
17192257
18586681
10734320
19651622
7592586
16157584
19369195
9582275
15674326
9528766
7693711
9841871
12758252
11309380
7750576
15212693
15659558
11274345
15735648
|
MAPK14
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
18.0
|
1.0
|
Omnipath
|
15187187
21675959
18039929
12738796
23397142
11238443
11274345
12697810
|
MAPK14
|
H3C2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
20626350
11278789
|
MAPK14
|
AR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
30644418
24424504
21820033
16282370
|
MAPK14
|
CDC25C
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
32.0
|
1.0
|
Omnipath
|
15150265
10744722
9836640
9543386
12941695
20068231
9278512
10681541
16189514
15791647
11551930
9278511
11333986
15629715
10557092
|
MAPK14
|
JUN
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
12475989
17689131
17570479
25483191
|
NRAS
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
RAF1
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
25435214
20179705
20141835
16364920
20130576
15035987
25907612
|
FGFR4
|
MAPK3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
19652666
12419216
18452557
12974390
|
FGFR2
|
MAPK3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
19652666
12419216
18452557
12974390
|
MAPK3
|
FGF23
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
19652666
12419216
18452557
12974390
|
MAPK11
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
12738796
18039929
11274345
15187187
|
MAPK3
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
23331499
18463697
9155018
21071413
32482868
18988627
15210690
|
MAPK3
|
ARHGEF2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
28096473
24043311
18211802
19261619
|
MAPK3
|
H3-3B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
15994958
11278789
12917630
|
MAPK3
|
MBP
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
10.0
|
1.0
|
Omnipath
|
10339476
16401070
1939237
1699809
|
MAPK3
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
14654779
23331499
19541618
18691976
16407412
19933846
9446616
9922370
15664191
18988627
|
MAPK8
|
MAPT
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
34342183
17314187
33557920
15312816
17761554
33762974
33842885
12614922
15136685
17270732
15228592
28758999
34385305
8506352
15994305
|
PKN1
|
MAPT
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
46.0
|
1.0
|
Omnipath
|
9565682
11181841
9614189
9832145
11104762
12387894
12226093
19562805
12714590
19857203
12435421
9546672
9771888
19413330
9199504
8999860
|
MTOR
|
EIF4B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
31.0
|
1.0
|
ACSN
|
12150925
12408816
12844354
12867079
12906785
15755954
15905173
16286006
16469695
16679021
17368478
17680028
18391071
18492954
19022819
19339977
19568798
19597330
19864431
20647036
21157483
21177869
21233202
21981924
23087689
24795729
24973821
25002027
25730849
26159692
28216025
|
MTOR
|
EIF4B
|
â—¼ SHARES_COMPLEX
|
|
|
31.0
|
1.0
|
ACSN
|
12150925
12408816
12844354
12867079
12906785
15755954
15905173
16286006
16469695
16679021
17368478
17680028
18391071
18492954
19022819
19339977
19568798
19597330
19864431
20647036
21157483
21177869
21233202
21981924
23087689
24795729
24973821
25002027
25730849
26159692
28216025
|
MTOR
|
MYC
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
23.0
|
1.0
|
ACSN
|
12150925
12408816
12906785
15755954
16469695
17604271
17680028
18372248
18492954
19022819
19446321
19568798
19706736
19864431
21157483
21981924
23087689
24795729
24973821
25002027
25730849
26159692
28216025
|
MTOR
|
AKT1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
45.0
|
1.0
|
ACSN
|
10722653
10949026
11274345
11715018
11756412
11756498
11923280
12408816
12906785
15169778
15808505
16469695
16697215
17052453
17461779
17680028
18000759
18372248
18492954
18570873
18636226
18925875
19022819
19143635
19151919
19568798
19720745
20027184
20138985
20214616
20338997
20398329
20832730
21157483
21474067
21981924
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
9812896
|
MTOR
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
80.0
|
1.0
|
Omnipath
|
18000759
20027184
21157483
11756412
11923280
24670654
16697215
11438723
21592956
20398329
17461779
18372248
21177249
21045808
20338997
15808505
16221682
20138985
20489726
15899889
20214616
8978681
21474067
14970221
19203586
17660512
15718470
19568798
20333297
23006971
15169778
25241761
18566586
19720745
17517883
18925875
22084251
10949026
14761976
11715018
19143635
17277771
18636226
10910062
15047712
9812896
18505677
21343617
19844585
17680028
19151919
18566587
9736715
23872070
10722653
20832730
18570873
17013611
17052453
12408816
15364915
11274345
|
JUN
|
MYC
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
40.0
|
1.0
|
ACSN
|
11274345
11929833
11955436
11967263
12051714
15001769
15576399
15768032
15806138
16007074
16039586
16169192
16510874
17050667
17143292
17291450
17439715
17936032
18347071
18627596
19619488
19623618
20006983
20122174
20530697
20705860
20920541
21285352
21767405
22290435
22705350
22761862
23306204
23343194
24023259
25730849
26587781
7542250
8545107
8666229
|
MYC
|
PDK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
20.0
|
1.0
|
ACSN
|
11274345
11283613
11283614
11704864
16517405
16517406
17055429
17558397
17785433
17873522
20027199
20237412
20551172
20581311
20713526
21406394
2191300
22067385
25002027
28536364
|
JUN
|
MYC
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
21835891
8276360
1774959
2498162
21607323
20410304
14523011
18037408
|
MYC
|
CCNE1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
18802399
20607601
14519204
22583478
9188852
11983916
11509615
|
MYC
|
H4C6
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
12747840
12695333
|
JUN
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
29.0
|
1.0
|
Omnipath
|
15806138
16510874
22290435
18627596
19623618
11929833
23343194
15768032
22761862
17050667
16039586
20122174
17291450
20920541
17143292
20006983
17439715
15576399
21767405
23306204
8545107
22705350
18347071
16007074
16169192
21285352
20530697
19619488
11274345
|
PPP2R5D
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
19131971
10026142
10995457
18042541
18559511
16680151
|
CDR2
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
10465786
20383333
|
KMT2A
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
20677832
16510874
|
MAPK8
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
25.0
|
1.0
|
Omnipath
|
19651622
10551811
17081983
18767875
20068231
91332050
1651323
1748630
16713569
11243879
18669648
15210690
|
NRAS
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
31135801
24897931
8665852
17998941
11136978
21779505
8052307
12121613
1716764
26085527
21779497
12094235
|
FGFR4
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
Reactome
|
17505008
18757403
21666749
11689702
11739186
18381441
19809159
21160078
14534538
15448205
|
PIK3CA
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
999.0
|
1.0
|
STRING
|
36370105
|
PIK3R1
|
FGF23
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11353842
9632781
14534538
9182757
|
KIT
|
PIK3R1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
27.0
|
1.0
|
Omnipath
|
9092574
17496910
1382595
11071635
25241761
24728074
7509796
7537096
12878163
10022833
16713569
7520444
17452978
9233773
|
EPOR
|
PIK3R1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
23331499
7559499
15644415
16713569
24113870
9162069
|
IGF1R
|
PIK3R1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
8603569
17496910
25241761
8697095
7642582
17570479
18595745
7589433
|
IL7R
|
PIK3R1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
9233603
7522165
|
PDGFRB
|
PIK3R1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
38.0
|
1.0
|
Omnipath
|
10752619
8564419
1372092
7486683
7692233
7536927
16713569
11710529
8382612
8086421
11896612
8670861
8388538
9153411
1330535
17496910
1314164
16135792
7680644
19864249
10697503
15377662
|
PIK3R1
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
10527852
16799564
19442713
|
WDR5
|
RBBP5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
ACSN
|
11302744
12874027
17168535
19407509
|
WDR5
|
RBBP5
|
â—¼ SHARES_COMPLEX
|
|
|
4.0
|
1.0
|
ACSN
|
11302744
12874027
17168535
19407509
|
TRAF2
|
TNFRSF1B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
22.0
|
1.0
|
ACSN
|
10465784
11274345
11668179
12048245
12556535
12655147
12738796
15170913
15592525
17462996
17496911
18641653
18855897
19392652
21133840
21232017
21614932
23070005
23850759
24378531
9379049
9582321
|
TRAF2
|
TNFRSF1B
|
â—¼ SHARES_COMPLEX
|
|
|
22.0
|
1.0
|
ACSN
|
10465784
11274345
11668179
12048245
12556535
12655147
12738796
15170913
15592525
17462996
17496911
18641653
18855897
19392652
21133840
21232017
21614932
23070005
23850759
24378531
9379049
9582321
|
TNFRSF1B
|
MAP2K3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
14.0
|
1.0
|
ACSN
|
11274345
12556535
12655147
12738796
15592525
17462996
18641653
18855897
19392652
21133840
21232017
21614932
23850759
24378531
|
TNFRSF1B
|
TRAF2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
40.0
|
1.0
|
Omnipath
|
8702708
10206649
16713569
8069916
7544915
18161752
14743216
9162022
15572357
18671942
9461607
8855313
11907088
8710854
11112773
15485837
9168896
8548810
7639698
|
TNFRSF1B
|
TRAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
18429822
9168896
8548810
9162022
16713569
7859281
8069916
|
FZD7
|
CYBA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
16636067
18347018
11779461
12716910
8947551
16329988
16762923
|
CD14
|
CCL2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
25.0
|
1.0
|
ACSN
|
11274345
11964313
12620219
12682231
12907458
14607900
14660645
15749884
15749903
16127449
16243976
16413922
16713974
16878026
17404308
17485448
17704786
18633355
20547845
21372296
21826665
23508573
23681101
23811849
9743347
|
JUN
|
CCL2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
19162185
18024959
18443042
14752027
22674286
23583295
19299558
12667961
10918580
19371341
26554515
|
PKN1
|
CDR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
9637778
32296183
25416956
|
JUN
|
VIM
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
7986748
14654785
2922288
16831196
|
AKT1
|
VIM
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
20856200
|
HESX1
|
NPPA
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
8.0
|
1.0
|
Omnipath
|
16909307
12023302
20874724
15081310
11847222
9295358
19799869
16166646
|
TRAF2
|
TRAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
49.0
|
1.0
|
ACSN
|
10820262
10925299
11112697
11274345
11280761
11438547
11460167
11875494
12433365
12646658
12811837
1431106
14607933
14625680
14660645
15099563
15592525
15699106
16713974
17301840
17462996
17916596
18264787
18345002
18633355
18641653
19392652
19411070
20038811
20184663
20435894
21133840
21232017
21411734
21826665
22955274
23170255
23430059
23508573
23510023
23567181
23769623
23850759
24092389
24378531
24699077
24958845
26201938
8910423
|
TRAF2
|
TRAF1
|
â—¼ SHARES_COMPLEX
|
|
|
49.0
|
1.0
|
ACSN
|
10820262
10925299
11112697
11274345
11280761
11438547
11460167
11875494
12433365
12646658
12811837
1431106
14607933
14625680
14660645
15099563
15592525
15699106
16713974
17301840
17462996
17916596
18264787
18345002
18633355
18641653
19392652
19411070
20038811
20184663
20435894
21133840
21232017
21411734
21826665
22955274
23170255
23430059
23508573
23510023
23567181
23769623
23850759
24092389
24378531
24699077
24958845
26201938
8910423
|
TRAF2
|
MAP2K3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
14.0
|
1.0
|
ACSN
|
11274345
12556535
12655147
12738796
15592525
17462996
18641653
18855897
19392652
21133840
21232017
21614932
23850759
24378531
|
TRAF2
|
TRAF1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
49.0
|
1.0
|
ACSN
|
10820262
10925299
11112697
11274345
11280761
11438547
11460167
11875494
12433365
12646658
12811837
1431106
14607933
14625680
14660645
15099563
15592525
15699106
16713974
17301840
17462996
17916596
18264787
18345002
18633355
18641653
19392652
19411070
20038811
20184663
20435894
21133840
21232017
21411734
21826665
22955274
23170255
23430059
23508573
23510023
23567181
23769623
23850759
24092389
24378531
24699077
24958845
26201938
8910423
|
TRAF2
|
IKBKB
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
13.0
|
1.0
|
ACSN
|
11274345
12847084
15592525
17462996
18641653
19392652
19509052
21133840
21232017
23430059
23850759
24378531
26587781
|
TRAF1
|
TRAF2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
37.0
|
1.0
|
Omnipath
|
8702708
15383523
16713569
8069916
21903422
25996949
9500555
14743216
11181075
15323523
25241761
14557256
20385093
32296183
10544141
12887920
19287455
8548810
9718306
31515488
29748372
|
TRAF2
|
TRAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
37.0
|
1.0
|
Omnipath
|
8702708
15383523
16713569
8069916
21903422
25996949
9500555
14743216
11181075
15323523
25241761
14557256
20385093
32296183
10544141
12887920
19287455
8548810
9718306
31515488
29748372
|
TRAF2
|
MAP2K3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
12655147
21614932
12738796
11274345
18855897
|
TRAF2
|
IKBKB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
18.0
|
1.0
|
Omnipath
|
27387502
15725726
12547194
11359906
25241761
20449947
16713569
18362886
23007157
10795740
21119000
19150425
|
JUN
|
CCL5
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
11413310
10760799
19828633
10075858
20862675
26096887
7513046
|
IL6
|
IL6R
|
â—¼ PHYSICAL_INTERACTION
|
|
|
35.0
|
1.0
|
ACSN
|
11306493
11867689
12754507
1439146
14610620
15099563
15356132
15573129
18209571
18555777
18555778
19581928
19833085
20138012
20406969
21115385
21840487
23034983
23567181
24011634
24091328
24346288
24418198
25002027
25582338
26201938
26268945
27216177
27557510
7512720
7521688
7543512
7590867
8837607
9845545
|
IL6
|
IL6R
|
â—¼ SHARES_COMPLEX
|
|
|
35.0
|
1.0
|
ACSN
|
11306493
11867689
12754507
1439146
14610620
15099563
15356132
15573129
18209571
18555777
18555778
19581928
19833085
20138012
20406969
21115385
21840487
23034983
23567181
24011634
24091328
24346288
24418198
25002027
25582338
26201938
26268945
27216177
27557510
7512720
7521688
7543512
7590867
8837607
9845545
|
CD14
|
IL6
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
25.0
|
1.0
|
ACSN
|
11274345
11964313
12620219
12682231
12907458
14607900
14660645
15749884
15749903
16127449
16243976
16413922
16713974
16878026
17404308
17485448
17704786
18633355
20547845
21372296
21826665
23508573
23681101
23811849
9743347
|
IL6
|
IL6R
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
35.0
|
1.0
|
ACSN
|
11306493
11867689
12754507
1439146
14610620
15099563
15356132
15573129
18209571
18555777
18555778
19581928
19833085
20138012
20406969
21115385
21840487
23034983
23567181
24011634
24091328
24346288
24418198
25002027
25582338
26201938
26268945
27216177
27557510
7512720
7521688
7543512
7590867
8837607
9845545
|
AR
|
IL6
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
12237244
8824277
19074897
11049111
17374439
11410519
20610535
19363165
|
JUN
|
IL6
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
24.0
|
1.0
|
Omnipath
|
26513016
10542237
21069809
15389813
15158360
20225236
12667961
20371366
20511231
20862675
8453101
10202034
18502099
10037779
8830832
19687301
21098092
25567680
20351184
17341596
11120852
21312239
24676671
|
IL6
|
IL6R
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
55.0
|
1.0
|
Omnipath
|
17145710
8702737
7744001
23663276
15895091
9028955
1995637
23331499
12829785
3136546
21071413
14656210
28265003
12643274
7893704
18923185
11238858
8706672
8676083
18067990
2788034
14557255
18775332
9694899
7744875
|
JUN
|
RAF1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
6.0
|
1.0
|
ACSN
|
11274345
12738796
17439715
18039929
26587781
8545107
|
AKT1
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
51.0
|
1.0
|
Omnipath
|
19197339
11971957
18767875
20230923
10576742
20068231
17570479
16189514
18669648
25241761
18691976
10576741
10618391
20688159
21745501
12087097
12801936
12048182
22798428
16854453
19058874
11997508
|
PKN1
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
15849194
11733498
|
YWHAH
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
12801936
11697890
8702721
17979178
|
NRAS
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
46.0
|
1.0
|
Omnipath
|
9867809
12750173
12932319
9001246
9665134
8805624
1386920
1639773
8340422
8601312
19595761
23331499
21071413
8332195
10531446
10882715
7811320
1996324
18988627
21779497
8636091
8503013
7766599
16093354
19541618
8180183
1708096
19933846
32296183
9525741
8876196
11136732
10205168
21478863
7760835
18775988
12917261
11134016
18641128
20080631
9488663
1990291
|
JUN
|
INS
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
8.0
|
1.0
|
Omnipath
|
1310538
9062890
9270011
7862133
20424231
22563476
14578290
8264634
|
JUN
|
NGF
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
11905996
11733514
8717334
2111020
|
JUN
|
IFNB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
9660935
18035482
22065573
10848607
20048166
22083261
17376932
|
AR
|
JUN
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
11577103
11518798
9211894
8798722
16713569
9591784
17721441
|
MAPK8
|
JUN
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
202.0
|
1.0
|
Omnipath
|
17143273
17804415
10617656
8846788
15958389
11948398
10882101
20028971
12697749
15894542
20514406
14612408
17875713
9891069
17570479
18922473
11809792
8586671
11896587
12185592
12871843
7992057
7600582
11278395
8137421
8001819
10493750
14557262
16549498
18707149
9169478
11460167
15289320
8157646
16007099
20506250
22110360
15378002
9687508
12740383
20732415
9305638
19270716
23331499
10747973
16291755
16393692
12832416
18988627
10713700
18669648
12087092
14633987
8525045
15677475
16076903
16166642
18650425
15590691
1608942
19910486
18212344
11562357
12228228
16740711
14701799
19690332
10871633
12531896
16713569
8654373
16983342
19664995
15302935
10962563
15068801
8621542
8607977
18362184
10393177
20068231
9808624
14572659
8224842
10585392
9407028
17363973
19527717
19436832
14517282
12407442
9487126
9692890
14523011
15212693
10908726
11108663
13130464
10064600
18429822
15299005
9774977
11907583
12963725
16824735
19413330
10617104
17055484
21071413
18452278
16434970
16157600
7737130
23816567
10987838
17189706
9561845
9575168
1460037
7652575
18617513
24113186
11971971
11801649
25098452
20058876
16533805
9184210
18003900
9315636
10385525
18957422
12881422
11274345
12052834
15749833
|
JUN
|
CCND3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
18813803
19219074
16406505
16880536
16054035
19190345
17000779
17439715
8545107
16396903
11274345
20107231
|
IKBKB
|
CD14
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
15064760
15814722
16115877
16603398
16547522
|
IFNB1
|
IFNAR2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
15312780
9121453
10395669
9334213
15778442
12842042
17969444
|
IFNA4
|
IFNAR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
21856167
|
IFNB1
|
IFNAR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
23331499
8181059
10395669
7623815
11278538
1127853810395660
|
IFNA16
|
IFNAR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
21856167
|
IFNA21
|
IFNAR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
21856167
|
AKT1
|
EIF4B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
18836482
17570479
25749412
|
PDPK1
|
NRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
10228164
15314172
11689445
28539435
11726503
19879889
8635462
|
PDPK1
|
AKT1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
8.0
|
1.0
|
ACSN
|
11687500
11747822
12670391
15802604
17680028
18802401
19109239
19122654
|
IGF1R
|
PDPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
20044479
11054117
17570479
20643654
|
PDPK1
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
156.0
|
1.0
|
Omnipath
|
15505410
12538620
12176337
19951971
24352480
11752451
19401591
11369519
10698680
10601311
15718470
24950409
20481595
24169049
10570282
16798838
14993273
11500365
9368760
19844585
17680028
7637810
9169478
26256536
7722458
9094314
12750173
11438723
18802401
9252186
23331499
18456494
9104825
10592173
16189514
20361045
18988627
11278835
20163786
20333297
20041157
12808134
19602588
8630736
10207050
11241670
10438924
9868760
25912234
20153221
25582703
11445557
21775285
12149249
14666721
18596232
9512493
23397142
11809791
12167717
21798082
16033886
10679787
16787925
29562639
15550174
21071413
8978681
10833263
19203586
10226025
26937223
14500673
20161206
11136732
11825911
11042193
9642236
22569334
18662999
9736715
12242303
11313365
11598012
11134526
|
PDPK1
|
PKN1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
23.0
|
1.0
|
Omnipath
|
10753910
10467162
10792047
16189514
26296974
10764742
18669648
|
FGF3
|
FGFR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
23331499
75926248663044
16597617
8663044
7592624
25772309
|
IGF2
|
IGF1R
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
Reactome
|
1310594
3019338
2839228
1845984
2969892
3011795
3013881
22140443
19139090
16981855
|
IGF2
|
IGF1R
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
ACSN
|
11237532
15003992
17145802
17600088
24668028
|
AR
|
IGF1R
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
19318566
15033751
17202144
19250214
20610535
|
INS
|
IGF1R
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
23331499
1851182
18988627
|
IGF2
|
IGF1R
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
9972281
23331499
22810696
20980691
14604834
11867533
|
AR
|
AKT1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
20589722
11278645
17896924
18687691
22740037
12621049
12063252
22970326
|
PPP2R5D
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
10.0
|
1.0
|
Omnipath
|
18039929
19216069
10026142
10995457
18042541
20452955
18559511
18588945
16680151
16406523
|
INS
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
29432553
23912456
11679435
23866690
17335965
24646332
23798298
|
PHLPP2
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
11.0
|
1.0
|
Omnipath
|
18511290
15899889
19797085
17386267
15808505
19261608
|
PIK3CA
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
25793261
19117013
21041639
24950409
21816939
|
PDK1
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
25.0
|
1.0
|
Omnipath
|
12176337
15743829
12682057
11445557
15899889
12149249
10833263
15718470
11278835
10226025
11087733
14500673
16341064
19897009
9368760
24012393
11825911
9512493
9736715
11313365
9868760
15364915
|
AKT1
|
IKBKB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
15184909
25241761
22689577
15856005
10485711
17660512
|
AKT1
|
AR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
30.0
|
1.0
|
Omnipath
|
17470458
18349820
29861848
16210317
21601007
17570479
11404460
22155408
12621049
14555644
11156376
|
AKT1
|
H3-3B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
12588998
12529330
|
AKT1
|
YWHAH
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
18.0
|
1.0
|
Omnipath
|
20138985
15169778
9812896
17680028
11756412
11923280
20214616
16697215
10949026
10722653
20832730
18570873
18372248
11715018
20398329
17052453
18636226
15808505
|
FGF18
|
FGFR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
23331499
10751172
16597617
8663044
25772309
|
FGF23
|
FGFR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
16597617
16081635
12032146
1608163512032140
|
FGF22
|
FGFR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
23331499
16597617
12591959
8663044
25772309
|
MAPK8
|
CDC25C
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
8.0
|
1.0
|
Omnipath
|
12742231
20220133
8119945
7513216
|
PKN1
|
MARCKS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
44.0
|
1.0
|
Omnipath
|
17081983
20166139
18767875
17322306
11162562
19413330
19664995
18578522
91317794
20068231
11930178
16116087
18669648
17114649
8557118
17287340
14963034
19651622
20058876
18707149
18212344
15708490
|
PA2G4
|
AR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
10.0
|
1.0
|
Omnipath
|
17145710
15583694
9565586
12165860
|
FGFR4
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
9.0
|
1.0
|
Reactome
|
17505008
18757403
21666749
11689702
21711248
11739186
21160078
14534538
15448205
|
NRAS
|
PIK3CA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
8052307
7820549
9150145
8665852
21779497
|
KMT2A
|
H3C2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
12453419
20210320
24680668
29897600
31485071
20541251
24235145
20452361
|
MAP2K3
|
MAPK11
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
18291705
11704645
23331499
11242034
19369195
21614932
14724572
12738796
11274345
18083107
18855897
|
NCOA2
|
AR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
27.0
|
1.0
|
Omnipath
|
9717843
12588987
15684378
14593076
24239470
15563469
18780293
12810069
16713569
10601285
14966121
10935543
10454556
|
CASP1
|
AR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
9535906
16713569
|
MAPK8
|
AR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
24424504
21512132
21820033
16282370
|
MAPK8
|
H3-3B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
15994958
11278789
12917630
|
FGF23
|
FGFR4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
16597617
16081635
25772309
|
NRAS
|
FGFR4
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
Reactome
|
19946327
11429702
11157491
18757403
21666749
21711248
18381441
19103595
21160078
9857065
20179196
|
CARD18
|
CASP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
10.0
|
1.0
|
Omnipath
|
15383541
27043298
11051551
11536016
11432859
|
CASP1
|
MEFV
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
16785446
16037825
17431422
18577712
|
CASP1
|
CASP5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
11051551
11536016
11432859
15383541
|
EPO
|
EPOR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
49.0
|
1.0
|
Omnipath
|
17145710
8662939
9442088
15358619
9030560
9974393
9774108
18586265
23331499
2163696
10318834
21889455
17327410
16982323
29997244
9808045
|
FGF18
|
FGFR4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
10751172
16597617
25772309
|
CARD18
|
CASP5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
11051551
11536016
11432859
15383541
|