Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
SP1 AKAP12 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17626016 20568114
SFN AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20005908 8009659
ESR2 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16549430 17261755
SMAD4 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CSNK1D APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SMAD3 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ESR2 APP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15040833 16675543
SMAD4 APP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12099698 15242331
CDC25A CHEK2 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 11298456 5213933
MAPK14 CDC25A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19289404
YWHAE CDC25B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12871587 5216545
CDC25B SFN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15173315 5217050
SP1 CDC25B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23160377 21242964
CHEK2 MDC1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 16651405 10724175
EP300 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23403292 24998469
SMAD2 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
HIF1A CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17382325 5219810
ESR1 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23403292 24998469
SMAD4 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9679056 9679060
CREBBP SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9679056 9679060
ESR1 EP300 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16704985 11279135
ESR1 HES1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18414489 19039095
ESR1 GNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19170076 18414489
NFATC1 FHL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19075112 24087791
RBPJ FHL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17509614 9418910
FHL1 NRIP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19401155
SP1 FHL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16624878 0602109103
HIF1A HES1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20010940 28602625
RBPJ HES1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19866488 10520600
HIF1A SP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19934262 15780936
IKBKE TANK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 intact 21212807 8142110
SP1 MDC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18173747
SP1 NRIP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22629304 20200160
SMAD4 PIAS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SP1 PRNP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19064990
TGFBR2 SMAD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 21358634 9679059
TGFBR2 SMAD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 21358634 9679059
ZEB1 SMAD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21421563
SRC SP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
SP1 SRF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10602487 10330138
TGFBR2 USP15 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22344298 16027725
HIF1A SP1 â—¼   PHYSICAL_INTERACTION 819.0 0.81 STRING 36370105
TITIN FHL1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22778266 23414517
ESR1 TITIN â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33731348 25604459
DEAF1 FHL2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 32296183
EGFR FHL2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 29321665 15657067
FHL1 ESR1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 19401155 22094188
MDC1 CHEK2 â—¼   KO_DOWN_REGULATES ✅ - -0.83 0.82 PKG 28854368
MYPC1 TITIN â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 23414517 1429890
AKT1 MAPK14 â—¼   PHYSICAL_INTERACTION 830.0 0.83 STRING 36370105
ESR2 EP300 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 18765668 11500849
ESR1 SRPK1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33731348 31527615 21182205
CHEK2 CDC25C â—¼   PHOSPHORYLATION ✅ - 0.83 0.83 Signor 12835754
FHL1 PRIO â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 18482256 28671123
APP PRNP â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
ESR2 MYLK2 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 21182203 25604459
SMAD2 ESR1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 11555647 20207742
ESR1 MYLK2 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 21182203 25604459 21182205 31527615
FHL2 FHL1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 16713569 12432079
ENO1 SRC â—¼   PHYSICAL_INTERACTION 851.0 0.85 STRING 36370105
EGFR AKA12 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 31980649 20029029
AKT1 SMAD2 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 24412244 16362038
SMAD4 EP300 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 18215124 25514493 10887155 22033265 9679056 14612423 9843571
ESR1 FHL2 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 31527615 15666801
CDC25B YWHAE â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
SRC EP300 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 26695438 10973497
PIAS1 ESR1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 31527615 11117529 15666801
ESR1 ESR2 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
CREBBP ESR1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
EGFR SFN â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
FHL2 TITIN â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 16713569 12432079
FHL1 AKA12 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 21900206 23414517
FHL1 MYPC1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 16407297 23414517
ESR1 EGFR â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11887937 17284441 20935677 28065597 16713569
SP1 EP300 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 10651903 34252870 16478997 11030335 11517158 15647279 17623675 17906698 28425985 32115405 31536933 12200149 24530506 23714681 10362258 22415975 16734381 19062177 10899165
SRC ESR2 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11032808 12630920 15604093 11013076 12095943
ESR2 NRIP1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 21182203 15604093 11500849
EP300 SMAD4 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
IKBKE TANK â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
AKT1 EP300 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
CREBBP SMAD3 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
CREBBP SMAD2 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
ESR1 NRIP1 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
EGFR AKT1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 31980649 25402006 24658140
SP1 SMAD3 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10878024 11114293 22227581 12228247 11432852 16714330
SP1 SMAD4 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10878024 18215124 11114293 21297662 22033265 16714330
CDC25A CHEK2 â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
SMAD2 SMAD3 â—¼   PHYSICAL_INTERACTION 899.0 0.89 STRING 36370105
FHL1 AKAP12 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
AKT1 SMAD3 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 25241761 16362038
SMAD3 CDC25A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21988832 15798217
DBN1 FHL1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
DEAF1 FHL1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
FHL1 EED â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
NRIP1 ESR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 9115274 26153859 8887632 16439465 26166704 9192902 21182203 23403292 33731348 7641693
ESR2 ESR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 19022902 19746436 10706629 12630920 9473491 21182203 29509190 17991765
SRC ESR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 17043237 17284441 17400812 15604093 11032808 17921256 18451880 15020686 12736255 11564893 23065768 10454579 20935677 17363140 16957778 14963108 11013076 29720121 15784253 24498420 17627277 12630920 22328528 14766010 24051437 7539106 27420286 15140878
ESR1 SRC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20160136 20460377 22865929
FHL1 PDE4DIP â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
FHL1 TXNIP â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
FHL1 HES1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
TGFBR2 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8774881 15104092
SP1 SMAD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21421563
SP1 SRC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10625617 19112177
ESR1 SP1 â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
FHL1 SUH â—¼   PHYSICAL_INTERACTION 0.91 0.91 HIPPIE 15710417 24952875 14999091 25609649
EP300 SP1 â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
CDC25C YWHAE â—¼   PHYSICAL_INTERACTION 919.0 0.91 STRING 36370105
FHL1 RING1 â—¼   PHYSICAL_INTERACTION 0.92 0.92 HIPPIE 15710417 14999091
ESR1 SRC â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
EP300 ESR1 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
FHL1 RBPJ â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
EGFR SRC â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
EP300 SMAD3 â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
CDC25C CHEK2 â—¼   PHYSICAL_INTERACTION 950.0 0.95 STRING 36370105
SRC EGFR â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 22227249 17284441 24658140 17158602 21278788 20333651 28065597 7527393 7797556 10777553 16713569 20624308 23175185 7506422 22973453 20935677 24189400 11983694 10075741 31980649 19704002 10358079 10971656 21268077 9020193 25402006 21573184 8845374
HIF1A EP300 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 18268343 15154850 12914934 19074848 25192544 22789427 20829524 21148070 17502379 26826385 22075993 16543236 19680224 20603618 19589782 11063749 23618863 26135796 27808477 22219185 15155277 11823643 17906695 19666581 21187066 16189267 8917528 23746844 19940151 19071119 26944191 15261140 24421387 20000859 12778114 14691445 12042299 22684029 12588875 17382325 23966271 15342390 22735262 27320910 26751287 24821806 23448368 11959990 15280364 11940656 19696166 20620956 16081065 22908229 18047470 16847340 22807441 23880760
CREBBP HIF1A â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
EP300 HIF1A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
SMAD2 SMAD4 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
SMAD3 SMAD4 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
HIF1A AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19144925 17220299 17488804 14726529 15277220
ESR1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11029009 15569929 18450422 20664923 15496458
SP1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19145069 15342781 21520171 18353772
SRC AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 11445557 25241761 23242524 18283331 12600984
AKT1 SFN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 20138985 15169778 9812896 17680028 11756412 11923280 20214616 16697215 10949026 10722653 20832730 18570873 18372248 11715018 20398329 17052453 18636226 15808505
AKT1 NRIP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10938135 17088940 16093479 16613989 11467847 7791761
AKT1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 18521086 26944939 11108261 17627277 20101208 17570479 15604293 23169992 26554417 16452229 15193262 7838153 12374744 11139588 26272591 11432835 20179234 11507039 9528769
AKT1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 17623675 18182168 16926151 20333651 19158375 17964260 17570479 11116148 25904863 21901101 23275565 16024795
AKT1 YWHAE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 20138985 15169778 9812896 17680028 11756412 11923280 20214616 16697215 10949026 10722653 20832730 18570873 18372248 11715018 20398329 17052453 18636226 15808505
AKT1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 25241761 15104092 16362038 21071413 18988627 26297431 15048128
SP1 APP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 19049493 8427604 15673661 9361293 21557719 18449948 14701757 8015372
CHEK2 CDC25A â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11438669 15459660 15810020 15867354 17296736 17464182 17568790 18048416 18566216 18756267 18931676 18971944 19686080 19788416 20019063 20126263
CHEK2 CDC25A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 52.0 1.0 Omnipath 18566216 12676583 15810020 18285803 12759351 14681206 20860841 16682204 9836640 10724175 29725502 23855452 20126263 18480045 11298456 20587702 15459660 20514219 22263797 27038604 17464182 14559997 12399544 17568790 24882577 19101576
CHEK2 CDC25B â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11438669 15459660 15810020 15867354 17296736 17464182 17568790 18048416 18566216 18756267 18931676 18971944 19686080 19788416 20019063 20126263
MAPK14 CDC25B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 19638579 12400006 17570479 16851915 11333986 15629715
CHEK2 CDC25B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 18566216 17464182 15810020 17568790 20126263 15459660
CHEK2 CDC25C â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11438669 15459660 15810020 15867354 17296736 17464182 17568790 18048416 18566216 18756267 18931676 18971944 19686080 19788416 20019063 20126263
CHEK2 CDC25C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 91.0 1.0 Omnipath 18566216 19165865 29774099 27427153 29302370 15810020 18321553 29425806 15707569 20860841 21152443 10681541 12711320 12505356 11551930 9836640 11333986 11583839 17097061 23880065 26485758 20637859 10744722 11240139 26633535 9889122 20599567 20068231 23788960 16481012 25914884 20126263 23705030 15791647 9278511 21924579 15629715 27801830 10097108 12814430 28094252 11313986 12941695 11728459 11053450 9278512 10557092 15459660 10435585 27038604 15150265 17464182 9543386 17568790 15282313 16488126 12478465 12835754
MAPK14 CDC25C â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 32.0 1.0 Omnipath 15150265 10744722 9836640 9543386 12941695 20068231 9278512 10681541 16189514 15791647 11551930 9278511 11333986 15629715 10557092
MDC1 CHEK2 â—¼   ENZYMATIC_REACTION ✅ 59.0 1.0 ACSN 11331603 11850621 11877377 12086603 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15242590 15279786 15375219 15377654 15459660 15485915 15798197 15964794 16163361 16332722 16531125 16713580 16805667 16818604 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17660363 18006705 18087292 18469862 18543256 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19282663 19342888 19622404 19686080 19772495 19793801 20051983 20723763 21376743 22743550 23847781 24050180 7575488 9407949 9488723
MDC1 CHEK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 12607004 18087292 17303408 20723763 18678890 19793801 9488723 12919958 24050180 15279786 7575488 16163361 18584027 18583988 22743550 16531125 23847781 18590585 15964794 21376743 12551934 12607003 17660363 15459660 19772495 11877377 18809224 11850621 9407949 18006705
HIF1A CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12542982 20547241 17452336 15907483 19489936 15342390 15184875
SP1 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23297421 20096088 9765204 21191649 21464950 12200429 20130956 12169688 15576380 15184875 15713621 18571793
CREBBP SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 16751102 18003620 9679056 15750622 17283070 20403362 17074756 15231748
CREBBP SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 15849193 10497242 15467747 18003620 9679056 15990875 15750622 19589780 17074756 17283070 9679060
CREBBP ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9192902 18765668 16417649 11113179 8616895 11782371 14766010 17400812
CSNK1D HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20699359
SP1 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 1282800 17616668 18575762 19538880 15665278 18202149 20435036 21705183 18007664 21464950 23821666 15533438 9819401 10830317 8393457 16087726 20407012 18391986
ESR1 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12894229 12421825 8200909 21705183
MAPK14 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 15187187 18039929 19138820 7535770 12738796 17139251 16932740 23397142 16785992 11274345
SRC EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 232.0 1.0 Omnipath 16414009 17081983 25958313 16943190 15618223 19935697 19305428 25402006 24797263 29285309 7488034 15592458 17389395 16461772 20562096 19275932 17897439 15899872 17570479 2803273 23636329 23246962 25505586 23175185 15615697 23349873 16849545 25356505 11983694 24189400 11756413 25748412 26325669 26150526 14512423 18789131 14750954 31978707 25573954 27495374 20071362 18707149 28759036 16729043 26494466 27716204 25537504 17237269 18687633 25884760 29036202 26936397 17575160 20926745 20935677 15282306 23702846 15476828 9069259 19336574 20421302 15660394 23866081 19377510 9777370 22426783 29321659 33706413 25841779 19840943 18669648 12397069 16843263 18957516 34088769 25077442 14963038 19836242 17653080 19625610 16936701 11960379 15548697 18295415 17523611 21268077 20333651 21399647 23376850 11250711 23942551 19704002 22927910 11160627 31952541 10777553 17016520 2543678 19258037 33883672 17646646 28102297 23873690 26771606 21573184 23119029 19151764 16713569 7797556 25955608 15302935 20407013 28513565 23119185 9990038 21080693 20190765 25347738 14630916 15708852 21822308 20628053 25301722 24658140 19690143 27564112 20802523 29124875 33657368 12101233 21787862 14764607 17284441 12878163 26290602 15951569 16543144 15212693 17971399 14523024 10971656 21278788 8845374 22430206 18083107 29641465 18234969 18460189 17551925 22957061 26571308 17043637 20371672 10358079 16799092 19154417 23066441 28065597 12842895 18180459 17158602 18271526 15657067 25159151 34367939 24919575 10075741 25366117 24349301 17561374 16862179 20215522 31980649 24335899 16037379 18451158 14530278 16505275 12063263 23449029 11311660
EGFR EPB41 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 2171679 1647028
EGFR ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 20809984 17284441 16713569 11887937
HIF1A ENO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19828020 8955077 15459207
SRC ENO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 8578591 7629021 15592455 15951569 96108162 15212693 24841372
EP300 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 9843571 19419955 22033265 9679056 21269274
EP300 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 9843571 11134049 12743039 15133024 15824515 15623506 16876108 21567395 16109717 17074756 20564330 10497242 15588252 17469184 15345715 11058129 10575014 16862174
EP300 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 21988832 23331499 9169454 12237408 10199400 11264182 7878020 8047140 12958365 19171760 11371641 16027720 17074756 17469772 21269274 15623506
EP300 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 75.0 1.0 Omnipath 24821806 12573436 17145710 16847340 12588875 19589782 11940656 25192544 11959990 18519678 23448368 22219185 11823643 12042299 15342390 23746844 19071119 19680224 27808477 15154850 19696166 8917528 17906695 18268343 22735262 21148070 15261140 19940151 23880760 22807441 35430356 14691445 12914934 20000859 12778114 26751287 16081065 22789427 16543236 24421387 17382325 17502379 22684029 21187066 19074848 23618863 23966271 20603618
SP1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 12237165 19351845 11345900 21235772 23209644 12429135 18006846 10982795 22622808 15691879 21191649
ESR2 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 14754635 24284820 15207704 18784357 11566442 12630920 22820289 19001520 18511514 14676837 19207817 22622808 21763263 18339713 15087130
ESR1 NRIP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20200160 10379892 16391242 22071320 18414489
NRIP1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 9192902 23331499 8887632 9115274 7641693 26166704 12554755 26153859 21182203 16439465
MAPK14 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23216744 22431515 12138194 15879307
SMAD3 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11555647 23331499
PIAS1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15666801 11117529
IKBKE ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23816933 20863366 19940156
SRC ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 15784253 25364741 17400812 16957778 17627277 15140878 11032808 23065768 12736255 7539106 17921256 27472465 14963108 24487689 25275301 12630920 22865929 14766010 30148069 11013076 15020686 9500442 17284441
ESR1 ESR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 12630920 9473491 19746436 21182203 10706629 10022879
ESR2 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11013076 12095943 12630920 11032808
SRC FERMT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 26037143 30248333
RING1 FHL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15710417 14999091
FHL1 RBPJ â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 24952875 15710417 9418910 14999091
SRF FHL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22456196 15610731 17975004
RBPJ HES1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 10520600 11120788 21311046 10066785 17611704 12814948 9819428 10933396 11866432 10205173 7566092 22718343
IKBKE TANK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 17823124 21212807 21138416 21931555 12133833 17568778 25852190 23007157 10759890
MAPK14 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 23331499 10197981 15241418 14512875 16156666 15520018
MAPK14 NFATC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 15649893 20516082 16648474 12944472 11997522 10788511 15304486 10747897 17255949 10652349 11274345 12697810
PIAS1 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 14514699 21988832 23331499 15028714 15231748
SMAD3 SMAD2 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10454538 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23869868 8515656 9312026 9389648 9618481 9670020 9865696
SMAD4 SMAD2 â—¼   PHYSICAL_INTERACTION 52.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11399519 11792802 11875494 12193690 12545156 12702545 12809600 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 17055429 17260466 17550342 17689680 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23390297 23784029 23869868 6357187 8515656 8871614 9312026 9389648 9618481 9670020
SMAD2 SP1 â—¼   PHYSICAL_INTERACTION 40.0 1.0 ACSN 10454538 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23869868 8515656 9312026 9389648 9618481 9670020
SMAD2 SP1 â—¼   SHARES_COMPLEX 40.0 1.0 ACSN 10454538 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23869868 8515656 9312026 9389648 9618481 9670020
TGFBR2 SMAD2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11274345 14557817 15265520 16474430 17934056 20060931 20519943 21614932 22703233 24132110 24336330
SMAD2 SMAD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16052471 11376804 11456453 9812998
TGFBR2 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 10678166 9463378 11792802 11133108 19920116 14557817 11278410 15178549 20060931 17934056 21614932 8980228 9311995 20519943 21900405 15548370 19010789 15104092 16474430 30093905 11274345 9865696
SMAD2 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 110.0 1.0 Omnipath 15613484 17145710 25609649 15817471 20211142 21532621 24584437 18729074 23788427 12419246 16916642 9288972 9892009 21454478 17510063 10531362 15231748 11027280 12167862 21988832 9389648 23331499 12543979 18568018 21071413 19135894 18511908 15467747 12808092 11927552 25514493 15350224 18988627 12732634 10878024 9111321 9311995 9346908 10199400 11264182 12957874 11114293 15761153 11274206 12621041 17272273 24157709 26555259 12374795 22442258 10781087 15922743 11102446 17591701 18783722 16751102 19139564 19917253 9346966 21297662 17283070 12794086
SMAD2 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 19558215 10878024 12631740 11013220 11114293
SMAD2 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 21988832 26186194 12543979 9111321 15084259 9311995 25878769 18729074 12700238
SMAD4 SMAD3 â—¼   PHYSICAL_INTERACTION 72.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013125 11013220 11074002 11114293 11224571 11279127 11283613 11283614 11376132 11399519 11792802 11875494 12193690 12545156 12702545 12809600 14976548 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 16831886 17018611 17055429 17260466 17550342 17563753 17689680 17705132 18353785 18768831 18832382 19208835 19597490 19815509 19901969 20027199 20713526 20731704 21041997 21042762 21098712 21252118 21317430 21577210 21614932 2191300 22331441 22514743 22652804 23140366 23338822 23390297 23784029 23869868 25374926 6357187 8515656 8871614 8893010 9312026 9389648 9618481 9670020
SMAD3 SP1 â—¼   PHYSICAL_INTERACTION 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
SMAD3 SP1 â—¼   SHARES_COMPLEX 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
TGFBR2 SMAD3 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11274345 14557817 15265520 16474430 17934056 20060931 20519943 21614932 22703233 24132110 24336330
SMAD3 SP1 â—¼   ENZYMATIC_REACTION ✅ 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
SMAD3 ZEB1 â—¼   DOWN_REGULATES ✅ - 22.0 1.0 ACSN 11074002 11279127 11792802 12702545 12809600 14976548 15265520 16179589 16713975 16831886 18768831 18832382 19208835 19597490 20731704 21042762 21317430 21614932 22331441 8515656 8893010 9389648
SMAD4 SMAD3 â—¼   LOCALISATION ✅ 72.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013125 11013220 11074002 11114293 11224571 11279127 11283613 11283614 11376132 11399519 11792802 11875494 12193690 12545156 12702545 12809600 14976548 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 16831886 17018611 17055429 17260466 17550342 17563753 17689680 17705132 18353785 18768831 18832382 19208835 19597490 19815509 19901969 20027199 20713526 20731704 21041997 21042762 21098712 21252118 21317430 21577210 21614932 2191300 22331441 22514743 22652804 23140366 23338822 23390297 23784029 23869868 25374926 6357187 8515656 8871614 8893010 9312026 9389648 9618481 9670020
SMAD3 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 104.0 1.0 Omnipath 25609649 9843571 15084259 20211142 21532621 24584437 18729074 23788427 12419246 18923419 9892009 19768112 10531362 15231748 9679060 12167862 21988832 12150994 23331499 12543979 18568018 21071413 19135894 15467747 25502805 9732876 11927552 16189514 12917407 25514493 15350224 10995777 18988627 10092624 12732634 25910212 10878024 9111321 20564330 27107012 9311995 12957874 20142324 11114293 32296183 15588252 15761153 24157709 26555259 29892012 17469184 22442258 16714330 21597466 15922743 22045334 17591701 24382352 22310290 19139564 19917253 29997244 31515488 28115363 10942775 21297662 17283070 12794086
SMAD4 ZEB1 â—¼   PHYSICAL_INTERACTION 36.0 1.0 ACSN 11074002 11279127 11792802 12490555 12702545 12743038 12809600 14623871 15265520 16510505 16617148 16713975 16831886 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18832382 19208835 19412634 19839049 20519943 20731704 21199805 21224848 21317430 21614932 21883379 22006115 22406545 225147423 22945800 9389648
SMAD4 SP1 â—¼   PHYSICAL_INTERACTION 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
SMAD4 SP1 â—¼   SHARES_COMPLEX 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
SMAD4 ZEB1 â—¼   SHARES_COMPLEX 36.0 1.0 ACSN 11074002 11279127 11792802 12490555 12702545 12743038 12809600 14623871 15265520 16510505 16617148 16713975 16831886 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18832382 19208835 19412634 19839049 20519943 20731704 21199805 21224848 21317430 21614932 21883379 22006115 22406545 225147423 22945800 9389648
TGFBR2 SMAD4 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11274345 14557817 15265520 16474430 17934056 20060931 20519943 21614932 22703233 24132110 24336330
SMAD4 SP1 â—¼   ENZYMATIC_REACTION ✅ 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
SMAD4 ZEB1 â—¼   UP_REGULATES ✅ + 36.0 1.0 ACSN 11074002 11279127 11792802 12490555 12702545 12743038 12809600 14623871 15265520 16510505 16617148 16713975 16831886 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18832382 19208835 19412634 19839049 20519943 20731704 21199805 21224848 21317430 21614932 21883379 22006115 22406545 225147423 22945800 9389648
TGFBR2 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8774881 20060931 11274345 21614932
SP1 TGFBR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 18053089 11507078 22028617 15647279 11687969 10982796 12750289 15895377 10766860 9632722 15905358
MDC1 MDC1 â—¼   KO_DOWN_REGULATES ✅ - -3.38 3.37 PKG 28854368