DVL2
|
APC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
7890890
20224554
|
DVL1
|
APC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
20224554
10330181
|
DVL2
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
20156660
27107012
|
JAK2
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
9209406
8400282
|
ID4
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
PIK3CA
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
GRB2
|
SMAD3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
GRB2
|
DVL2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
20156660
27107012
|
MAPK3
|
GRB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
7739560
8816480
|
MAPK1
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
8994038
|
FGFR1
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
9480847
16713569
|
RAF1
|
MAPK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
20674547
15664191
|
MAPK1
|
MAP2K1
|
â—¼ PHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
23241949
8412360
|
FGF2
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
9490736
12750158
|
MAPK11
|
MAPK14
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23602568
21900206
|
RAF1
|
MAPK3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
20674547
15664191
|
MAPK3
|
SOS1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
7739560
8816480
|
MYC
|
FGFR3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
ISL1
|
MYC
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
21829621
24845569
|
MYC
|
PIK3R1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19602047
11509615
|
MYC
|
EZH2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
21941025
19197161
|
AKT1
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
17942906
9804616
|
STAT3
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
22943793
15810077
|
ID4
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
THRA
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16966610
0601600103
|
PIK3R1
|
IGF1R
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.8
|
0.8
|
mint
|
6730400
7589433
|
PIK3R1
|
JAK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
PIK3R1
|
SOS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
PIK3R1
|
STAT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
25814554
15021914
|
RIF1
|
ID2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16169070
5217955
|
SMAD2
|
SKIL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
15231748
5217094
|
SKIL
|
SETDB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
15231748
5217094
|
SMAD4
|
SKIL
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
22674574
|
SKIL
|
SMAD1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
12419246
12426322
|
STAT3
|
SOX2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20132009
18447642
|
STAT3
|
IL6ST
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
9169475
|
STAT3
|
KLF4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17129668
|
WNT1
|
DLX5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18495817
|
FZD7
|
WNT5A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
20457807
24865425
|
CTNNB1
|
FZD7
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12095419
15473860
|
WNT8A
|
FZD7
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23331499
10097073
|
SMAD1
|
HAND1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
22219353
|
SMAD5
|
HAND1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
22219353
|
ID1
|
ID3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
21156287
22564737
|
KLF4
|
ID3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
12087069
19618124
|
ID3
|
TCF3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
24492847
20191379
|
TCF3
|
ID2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
19321746
0900912106
|
ID1
|
ID2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
9779825
19896442
|
POU5F1
|
ID2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
17068183
|
CTNNB1
|
ID2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11572874
12095419
|
PAX6
|
ITGB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10954416
|
SMAD9
|
SMAD4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16189514
5217968
|
SMAD5
|
SMAD4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
15231748
5217094
|
MAPK13
|
SMAD4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
15231748
5217094
|
SMAD4
|
ID1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19079362
12296825
|
ACVR1B
|
SMAD4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16189514
9892009
|
SOCS1
|
JAK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
10421843
10064597
|
LIF
|
JAK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
12601009
15519241
|
LIFR
|
JAK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23331499
11294841
|
SMAD9
|
SMAD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
15231748
5217094
|
SMAD9
|
SMAD2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
15231748
|
SMAD2
|
NANOG
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
21402155
|
SMAD3
|
FGF2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17637743
25374926
|
ACVR1C
|
SMAD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23331499
9920806
|
SMAD3
|
NANOG
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
21402155
|
JAK2
|
LIF
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
12601009
15519241
|
PIK3CD
|
JAK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
11598010
12506011
|
SOCS1
|
JAK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
10421843
6731094
|
JAK2
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
11598010
12506011
|
JAK2
|
PIK3CB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
11598010
12506011
|
JAK2
|
SOS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
9209406
8400282
|
LIFR
|
JAK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23331499
11294841
|
RAF1
|
AKT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
19197339
7014125
|
HRAS
|
DVL2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
HRAS
|
PIK3CB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
9069260
21779497
|
GSK3B
|
AXIN1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5219694
17318191
|
WNT3A
|
AXIN1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
10428961
8666229
|
FZD5
|
AXIN1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
10428961
8666229
|
FZD4
|
DVL1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
27096005
19388021
|
FZD2
|
DVL1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23151663
19388021
|
FZD3
|
DVL1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
22944199
19388021
|
FGFR3
|
DVL2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
WNT10B
|
FZD1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19008118
12055200
|
WNT6
|
FZD1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12857724
8717036
|
ID1
|
FGFR1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
16557594
21876767
|
PIK3R3
|
IGF1R
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
0611271104
17360667
|
IGF1R
|
PIK3R2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17496910
7541045
|
IGF1
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19183465
12875741
|
AKT1
|
DLX5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
21619873
22298955
|
EZH2
|
BMI1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
21465172
19351856
|
AKT3
|
BMI1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
22505453
|
TCF3
|
ID1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
22564737
17490644
|
FGFR2
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
15863030
11353842
|
FGFR3
|
MAPK11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
FGFR3
|
ID1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
FGFR3
|
WNT7A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
FGFR3
|
LHX5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
FGFR3
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
15863030
11353842
|
KLF4
|
NANOG
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19522013
|
KLF4
|
NANOG
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19522013
|
SMAD9
|
SMAD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
8893010
11779505
|
SMAD1
|
SMAD5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
15231748
5217094
|
PIK3CD
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
9885561
10455108
|
PIK3CA
|
PIK3CB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
9885561
10455108
|
CTNNB1
|
PIK3CA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16219695
|
GSK3B
|
CTNNB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5219694
17318191
|
GSK3B
|
APC2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23331499
10698523
|
CTNNB1
|
NANOG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
32448362
25921273
|
CTNNB1
|
TBX3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15592430
17283120
|
CTNNB1
|
NEUROG1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15142975
15031118
|
CTNNB1
|
SOX2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
24291232
24482235
|
CTNNB1
|
POU5F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
32803659
21295277
|
PIK3CD
|
PIK3CB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
9885561
10455108
|
PIK3R2
|
SOS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19531499
9651378
|
EZH2
|
WNT2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
20368440
21512140
|
SOX2
|
ISL1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
20739473
|
POU5F1
|
LEFTY1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16954384
17068183
|
POU5F1
|
NANOG
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17211451
|
ACVR2B
|
ACVR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23331499
16446785
|
ACVR2A
|
ACVR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
9748228
8612709
|
BMPR1B
|
ACVR2B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
7644468
7791754
|
BMPR1B
|
ACVR2A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
7644468
7791754
|
BMPR1A
|
BMPR1B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10712517
|
ACVR2B
|
BMPR1B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23331499
16446785
|
BMPR1B
|
SMAD9
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19620713
11792802
|
TCF7
|
NANOG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
32448362
25921273
|
SOX2
|
NANOG
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17211451
|
INHBE
|
ACVR2A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
22710174
|
ID1
|
BMP4
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
20970407
21996749
|
TBX3
|
BMP4
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
22387209
17173667
|
SMAD9
|
SMAD5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
8893010
11779505
|
BMPR1A
|
ACVR2B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
7644468
7791754
|
ACVR2B
|
ACVR1C
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23331499
16446785
|
WNT5B
|
FZD8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
26849959
20093360
|
BMPR1A
|
SMAD9
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19620713
11792802
|
ID4
|
SOX2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
21531766
23613880
|
WNT4
|
FZD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23331499
14671310
|
WNT5A
|
FZD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
19910923
19582886
|
WNT2
|
FZD2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
24032637
|
WNT5B
|
FZD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16273260
15578921
|
WNT11
|
FZD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16273260
15578921
|
APC2
|
CTNNB1
|
â—¼ RELOCALIZATION
|
✅
|
-
|
0.8
|
0.8
|
Signor
|
10980707
|
IGF1R
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
806.0
|
0.8
|
STRING
|
36370105
|
FGFR1
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
808.0
|
0.8
|
STRING
|
36370105
|
SMAD1
|
DVL1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.81
|
0.81
|
HIPPIE
|
12650946
|
GSK3B
|
SMAD1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.81
|
0.81
|
HIPPIE
|
25241761
18045539
|
IL6ST
|
JAK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
814.0
|
0.81
|
STRING
|
36370105
|
ACVR1
|
BMPR2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
814.0
|
0.81
|
STRING
|
36370105
|
HOXA1
|
ID3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.81
|
0.81
|
HuRI
|
32296183
|
DVL1
|
DVL2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
817.0
|
0.81
|
STRING
|
36370105
|
DVL1
|
APC
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
20224554
11425858
|
MYC
|
RIF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
21150319
29467282
|
AXIN1
|
AXIN2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
22682247
20128690
|
ID2
|
ID4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
DVL1
|
SMAD4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
12650946
|
SOCS1
|
JAK1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
10707961
11133764
29991678
29674694
|
SMAD2
|
SMAD9
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
15231748
33961781
|
FGFR2
|
FGFR1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
AKT3
|
AKT1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
PCGF6
|
BMI1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
24981860
12167161
|
PCGF1
|
BMI1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
24981860
26687479
|
BMI1
|
PCGF3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
22493164
24981860
|
PCGF5
|
PCGF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
22493164
24981860
|
PCGF1
|
PCGF6
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
22493164
24981860
|
WNT7A
|
WNT5A
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
WNT7A
|
WNT7B
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
WNT16
|
WNT5A
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
WNT5A
|
WNT5B
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
WNT16
|
WNT11
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
KRAS
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
824.0
|
0.82
|
STRING
|
36370105
|
AKT1
|
GSK3B
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
0.82
|
0.82
|
Signor
|
15829723
|
AKT1
|
GSK3B
|
â—¼ PHOSPHORYLATION
|
✅
|
-
|
0.82
|
0.82
|
Signor
|
23552696
|
FGF2
|
FGFR4
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
+
|
0.82
|
0.82
|
Signor
|
1385111
|
SOS1
|
KRAS
|
â—¼ GTPASE_REACTION
|
✅
|
+
|
0.82
|
0.82
|
Signor
|
25624485
|
MYC
|
PCGF6
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
35140242
30415952
29467282
|
AXIN1
|
DVL3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
22682247
12805222
20128690
|
WNT4
|
WNT5A
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
WNT4
|
WNT7B
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
WNT3A
|
WNT3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
AKT1
|
MAPK14
|
â—¼ PHYSICAL_INTERACTION
|
|
|
830.0
|
0.83
|
STRING
|
36370105
|
AXIN2
|
CTNNB1
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
0.83
|
0.83
|
Signor
|
11940574
|
AXIN1
|
DVL3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
834.0
|
0.83
|
STRING
|
36370105
|
CTNNB1
|
SMAD3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
837.0
|
0.83
|
STRING
|
36370105
|
NANOG
|
SOX2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
838.0
|
0.83
|
STRING
|
36370105
|
DVL1
|
SMAD3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
12650946
|
SMAD1
|
SMAD3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
9111321
15761153
18729074
|
SOCS1
|
IGF1R
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
32700452
9727029
29991678
|
SMAD5
|
ACVR1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
10652350
16189514
10583507
9748228
|
FZD8
|
WNT3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
839.0
|
0.84
|
STRING
|
36370105
|
GSK3B
|
CTNNB1
|
â—¼ PHOSPHORYLATION
|
✅
|
-
|
0.84
|
0.84
|
Signor
|
16293724
|
AXIN2
|
APC
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
+
|
0.84
|
0.84
|
Signor
|
10911903
|
MAPK1
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
847.0
|
0.84
|
STRING
|
36370105
|
KRAS
|
NRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
847.0
|
0.84
|
STRING
|
36370105
|
AXIN1
|
APC
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.85
|
0.85
|
mint
|
7025676
19131971
|
FZD8
|
WNT1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
15454084
11448771
|
AKT2
|
AKT1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
28514442
12149249
9736715
12176337
11445557
33961781
14500673
11278835
11546794
|
FGF2
|
FGFR3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
850.0
|
0.85
|
STRING
|
36370105
|
SMAD4
|
SMAD5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
853.0
|
0.85
|
STRING
|
36370105
|
CTNNB1
|
TCF7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
858.0
|
0.85
|
STRING
|
36370105
|
DVL2
|
APC
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
20224554
26496610
|
PIK3R1
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.86
|
0.86
|
mint
|
5220480
7642581
|
FGFR3
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
9045692
26344197
|
AKT1
|
SMAD2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
16362038
24412244
|
IGF1R
|
PIK3R3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
862.0
|
0.86
|
STRING
|
36370105
|
BHLHB9
|
OTX1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.86
|
0.86
|
HuRI
|
32296183
|
ACVR2B
|
BMPR1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
864.0
|
0.86
|
STRING
|
36370105
|
SOCS1
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
10022833
29991678
|
SMAD5
|
SMAD4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
10531362
16516194
16189514
15231748
|
SMAD3
|
SMAD9
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
28514442
15231748
33961781
26186194
|
JAK2
|
RAF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
9689060
11134016
8876196
10205168
|
PCGF2
|
BMI1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
28514442
20601937
33961781
24981860
|
HRAS
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
871.0
|
0.87
|
STRING
|
36370105
|
NRAS
|
RAF1
|
â—¼ RELOCALIZATION
|
✅
|
+
|
0.87
|
0.87
|
Signor
|
21779497
|
MAPK1
|
MAPK14
|
â—¼ PHYSICAL_INTERACTION
|
|
|
874.0
|
0.87
|
STRING
|
36370105
|
PIK3R2
|
PIK3R3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
874.0
|
0.87
|
STRING
|
36370105
|
PIK3R1
|
PIK3R2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
876.0
|
0.87
|
STRING
|
36370105
|
SMAD3
|
SMAD9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
876.0
|
0.87
|
STRING
|
36370105
|
HRAS
|
NRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
877.0
|
0.87
|
STRING
|
36370105
|
JAK1
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
11527382
8536716
|
AXIN2
|
GSK3B
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
12183362
10966653
33961781
23602568
32707033
23455922
29568061
30824926
|
IL6ST
|
JAK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
879.0
|
0.88
|
STRING
|
36370105
|
SMAD2
|
SMAD1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
9111321
28628118
18729074
28205554
|
GSK3B
|
SMAD3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
21310903
18172167
|
FGF2
|
FGFR3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
14613973
9045692
10574949
|
FGFR2
|
FGFR3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
28514442
23972473
33961781
|
ACVR1
|
SMAD1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
16189514
10583507
10652350
9748228
28847510
10085121
9136927
|
AKT1
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
880.0
|
0.88
|
STRING
|
36370105
|
AKT1
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
880.0
|
0.88
|
STRING
|
36370105
|
BMP4
|
BMPR2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
880.0
|
0.88
|
STRING
|
36370105
|
ID3
|
MYF5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.88
|
0.88
|
HuRI
|
32296183
|
JAK2
|
STAT3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
885.0
|
0.88
|
STRING
|
36370105
|
MAPK1
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
887.0
|
0.88
|
STRING
|
36370105
|
JAK1
|
STAT3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
888.0
|
0.88
|
STRING
|
36370105
|
ID3
|
TCF3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
888.0
|
0.88
|
STRING
|
36370105
|
FGFR2
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
24440983
22726438
|
MAPK1
|
STAT3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
889.0
|
0.89
|
STRING
|
36370105
|
MYC
|
MLH1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
12584560
29467282
|
MYC
|
GSK3B
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
16247449
11877389
14563837
20713710
19131971
21150319
31638140
8247524
29467282
33541412
|
SMAD3
|
SKIL
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
22442258
16959829
11306568
10531062
12764135
17469184
12426322
15231748
11691834
|
SMAD2
|
SKIL
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
18729074
16959829
22442258
10531062
12764135
33961781
12426322
15231748
25059663
11691834
|
JAK2
|
STAT3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
10925297
11294897
15156153
30413785
15284024
11350938
12626508
12576423
11940572
10918587
12244095
8626374
9211920
19834108
26775640
14551213
27351213
23838182
|
SMAD4
|
SMAD9
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
32296183
16189514
10583507
25502805
25609649
31932471
15231748
|
DVL1
|
DVL2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
24643799
28514442
20224554
33961781
26186194
31340145
|
DVL2
|
DVL3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
24643799
31340145
33961781
28514442
|
BMPR2
|
ACVR1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
7890683
28514442
7791754
|
ACVR2A
|
INHBA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
889.0
|
0.89
|
STRING
|
36370105
|
BMPR2
|
BMP4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
28126904
12045205
7673243
7644468
8702914
|
DUSP9
|
MAPK14
|
â—¼ PHYSICAL_INTERACTION
|
|
|
891.0
|
0.89
|
STRING
|
36370105
|
SKIL
|
SMAD3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
893.0
|
0.89
|
STRING
|
36370105
|
HRAS
|
KRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
893.0
|
0.89
|
STRING
|
36370105
|
FGFR2
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
894.0
|
0.89
|
STRING
|
36370105
|
SKIL
|
SMAD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
894.0
|
0.89
|
STRING
|
36370105
|
ACVR2A
|
BMPR1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
896.0
|
0.89
|
STRING
|
36370105
|
AXIN1
|
APC
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
16199882
22682247
10228155
29045831
18786926
20128690
19131971
26496610
10811618
9734785
29713058
23277359
17510365
|
AXIN2
|
APC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
10966653
10911903
9554852
|
PIK3CD
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
11002419
10995764
10448070
|
PIK3CB
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
11002419
10995764
10448070
|
JAK2
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
7500025
17474147
8536716
8950973
|
JAK1
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
8536716
11527382
|
MAPK1
|
DUSP9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
8287191
255844
21908610
|
MAPK1
|
MAP2K1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
10567369
19219045
8013650
|
MAPK1
|
MAP2K2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
10567369
19219045
8013650
|
MAPK1
|
DUSP9
|
â—¼ DEPHOSPHORYLATION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
17208316
22569528
20463170
|
MAPK1
|
POU5F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
23024368
|
MAPK11
|
MAPK14
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
MAPK14
|
DLX5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
18056716
|
MAPK3
|
MAP2K2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
10567369
19219045
8013650
|
MAPK3
|
MAP2K1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
10567369
19219045
8013650
|
MAPK3
|
DUSP9
|
â—¼ DEPHOSPHORYLATION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
17208316
22569528
20463170
|
FGF2
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
9490736
29436393
12750158
|
MAPK3
|
POU5F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
23024368
|
SMAD2
|
MYC
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
11804592
28628118
28205554
|
MYC
|
RAF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
17314511
9315742
28628118
28205554
|
SMAD1
|
MYC
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
3.0
|
0.9
|
ACSN
|
15576399
22290435
22761862
|
RBPJ
|
MYC
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
18490439
10644343
16847353
|
DLX5
|
MYC
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
19497851
|
MYC
|
MEIS1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12747840
|
MYC
|
FGFR4
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12695333
|
MYC
|
AKT1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
16846534
16489011
18562319
|
MYC
|
NRAS
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12695333
|
MYC
|
AXIN2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
19149881
24299953
|
MYC
|
WNT10B
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12747840
|
MYC
|
GSK3B
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12695333
|
MYC
|
BMP4
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12695333
|
MYC
|
SMARCAD1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12747840
|
AXIN1
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
19131971
20399964
|
SMAD4
|
SKIL
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
10531062
12764135
15761153
17469184
25609649
33961781
15231748
25059663
|
STAT3
|
CTNNB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
20830236
|
WNT7A
|
FZD7
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
19497282
22944199
23290138
|
FZD7
|
DVL1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
14636582
22179044
19388021
|
SMAD1
|
ID3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
18372118
21056086
|
SMAD5
|
ID3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
18372118
21056086
|
HOXD1
|
ITGB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
21501586
|
AKT1
|
ITGB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
16256741
10896934
|
SMAD2
|
SMAD4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
9111321
25514493
11927552
28443643
21988832
20211142
15467747
12732634
25609649
15922743
12419246
9288972
21454478
19139564
24157709
18729074
22442258
17283070
16916642
15350224
17591701
11274206
15761153
31591477
26555259
9892009
9311995
10085121
9389648
10781087
12167862
10878024
18783722
27703004
18511908
28468752
19135894
10531362
12794086
15231748
21297662
12621041
19917253
11027280
24584437
16751102
31932471
10199400
21532621
12808092
33961781
11264182
11102446
11114293
12543979
23788427
15817471
|
AKT1
|
SMAD4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
16362038
23397142
|
SMAD1
|
SMAD4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
9111321
17183365
16189514
32296183
31467278
12167862
14701756
12874272
28468752
15761153
24412244
10531362
15231748
11700304
11779505
26555259
9436979
21454478
|
SMAD3
|
SMAD4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
9111321
16189514
25514493
11927552
28443643
21988832
20211142
15084259
12732634
19768112
15467747
20142324
25609649
15922743
12917407
12419246
20564330
24382352
19139564
32296183
24157709
18729074
22442258
10092624
17283070
15350224
17591701
15761153
31591477
10995777
26555259
9892009
9311995
15588252
12167862
10878024
25910212
27703004
33990575
28115363
18055455
22310290
19135894
10531362
12794086
15231748
21297662
22045334
19917253
24584437
27107012
29892012
29997244
21532621
27845895
21597466
25502805
11114293
12543979
23788427
|
SMAD2
|
SMAD3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
899.0
|
0.9
|
STRING
|
36370105
|
ACVR1B
|
SMAD2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
11024047
12063393
14978253
|
SMAD2
|
ACVR1C
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
11024047
12063393
14978253
|
MAPK11
|
SMAD2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
23331499
20820849
|
ACVR1C
|
SMAD2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
23331499
9920806
16709598
|
SMAD2
|
SMAD1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
18729074
9111321
|
AKT1
|
SMAD3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
16362038
25241761
|
ACVR1B
|
SMAD3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
11024047
12063393
14978253
|
SMAD3
|
ACVR1C
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
11024047
12063393
14978253
|
ACVR1B
|
SMAD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
14517293
23331499
9605406
|
AKT1
|
RAF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
16189514
25241761
28628118
10576742
19197339
19058874
28205554
|
AXIN1
|
DVL2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
10829020
29659741
23892894
21245303
|
AXIN1
|
GSK3B
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
25241761
17601533
21988832
10228155
24976009
30181396
20128690
12511557
17318191
16293724
23455922
28546513
17318175
19303846
18632848
19131971
16890161
26496610
23892894
23602568
22613765
18593713
29568061
21242974
22682247
19759537
11738041
22270359
24451375
9734785
32707033
21502811
17510365
10481074
16199882
26912724
23959799
29045831
22509369
29789528
19202075
12584189
|
APC2
|
AXIN1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
23331499
9601641
10980707
|
DVL1
|
GSK3B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
10428961
16914735
20837657
|
WNT2
|
FZD4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
24032637
|
FGFR1
|
FGF2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
10748122
16829530
9174056
19627396
7520751
23597563
15096041
10950949
11030354
7730326
8609172
21693575
17086194
23597562
10574979
1697263
10490103
1722683
11786412
26267536
15548653
14505356
22539306
1709094
8868466
19696444
8692946
18199118
14613973
|
IGF1R
|
IGF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
26027733
21645859
8452530
|
AKT1
|
GSK3B
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
19713527
8524413
23824745
16009706
29464284
20856200
19995607
16123141
20682768
27563096
14645548
15688030
22337773
11035810
17428466
18505846
15470047
14701753
16282323
|
POU5F1
|
AKT1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
23041284
20683952
|
AKT2
|
BMI1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
23092893
22505453
|
MAPK11
|
TCF3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
15719023
|
SOCS1
|
JAK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
27144517
11133764
21508344
|
PIK3CA
|
SOS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
21653832
16456001
10068651
|
RBPJ
|
GSK3B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
GSK3B
|
FZD5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
CTNNB1
|
TCF7
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
15473860
17724465
10489374
|
CTNNB1
|
BMP4
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
10601040
12782598
15907834
|
DVL3
|
CTNNB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
10644691
10806215
|
DVL3
|
PIK3CB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
PIK3CB
|
SOS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
21653832
16456001
10068651
|
PIK3R2
|
PIK3CB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
22402981
8596638
11733063
|
PIK3R2
|
SOS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
21653832
16456001
10068651
|
SOS1
|
KRAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
25624485
23331499
16293107
|
AKT2
|
POU5F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
23041284
|
AKT3
|
POU5F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
23041284
|
INHBC
|
ACVR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12651901
|
ACVR1
|
SMAD9
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
10583507
16189514
11792802
|
ACVR2A
|
ACVR1B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12682303
9032295
8612709
|
INHBE
|
ACVR2B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
22710174
|
ACVR2B
|
BMPR1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
23331499
17295905
16446785
|
WNT8A
|
FZD8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
23331499
28733458
10097073
|
WNT9B
|
FZD5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
30978219
25892522
28733458
|
WNT3A
|
FZD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
21078818
18212053
10601008
|
INHBC
|
ACVR1B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12651901
|
WNT10B
|
FZD5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
23331499
11092808
12055200
|
SOS1
|
HRAS
|
â—¼ GTPASE_REACTION
|
✅
|
+
|
0.9
|
0.9
|
Signor
|
23132018
|
GRB2
|
SOS1
|
â—¼ RELOCALIZATION
|
✅
|
+
|
0.9
|
0.9
|
Signor
|
23452850
|
GRB2
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
908.0
|
0.9
|
STRING
|
36370105
|
JAK2
|
SOCS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
909.0
|
0.91
|
STRING
|
36370105
|
APC
|
GSK3B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
910.0
|
0.91
|
STRING
|
36370105
|
BMP4
|
BMPR1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
919.0
|
0.92
|
STRING
|
36370105
|
AXIN2
|
GSK3B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
920.0
|
0.92
|
STRING
|
36370105
|
MAP2K2
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
924.0
|
0.92
|
STRING
|
36370105
|
NRAS
|
RAF1
|
â—¼ PROXIMITY
|
✅
|
|
0.93
|
0.93
|
mint
|
30194290
|
AKT1
|
GSK3B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
934.0
|
0.93
|
STRING
|
36370105
|
PIK3CB
|
PIK3R3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
934.0
|
0.93
|
STRING
|
36370105
|
POU5F1B
|
SOX2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
937.0
|
0.93
|
STRING
|
36370105
|
PIK3CB
|
PIK3R2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
938.0
|
0.93
|
STRING
|
36370105
|
SOS1
|
HRAS
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.94
|
0.94
|
mint
|
17084389
5219305
|
CTNNB1
|
AXIN1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.94
|
0.94
|
mint
|
5219694
17318191
|
EZH2
|
JARID2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
939.0
|
0.94
|
STRING
|
36370105
|
NANOG
|
POU5F1B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
940.0
|
0.94
|
STRING
|
36370105
|
PIK3CA
|
PIK3R3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
941.0
|
0.94
|
STRING
|
36370105
|
FGF2
|
FGFR2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
942.0
|
0.94
|
STRING
|
36370105
|
APC2
|
CTNNB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
943.0
|
0.94
|
STRING
|
36370105
|
NRAS
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
945.0
|
0.94
|
STRING
|
36370105
|
PIK3CB
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
947.0
|
0.94
|
STRING
|
36370105
|
SMAD4
|
SMAD1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.95
|
0.95
|
mint
|
17183365
5219486
|
DVL1
|
DVL3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.95
|
0.95
|
HIPPIE
|
32296183
10330181
|
SMAD4
|
SMAD9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
950.0
|
0.95
|
STRING
|
36370105
|
ACVR2B
|
INHBA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
953.0
|
0.95
|
STRING
|
36370105
|
ID2
|
TCF3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
955.0
|
0.95
|
STRING
|
36370105
|
ID1
|
TCF3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
955.0
|
0.95
|
STRING
|
36370105
|
FGF2
|
FGFR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
957.0
|
0.95
|
STRING
|
36370105
|
MAP2K2
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
958.0
|
0.95
|
STRING
|
36370105
|
CTNNB1
|
APC
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.96
|
0.96
|
mint
|
36950384
|
LIF
|
LIFR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.96
|
0.96
|
HIPPIE
|
8999038
8662595
16051226
9852103
12601009
|
SOCS1
|
JAK2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.96
|
0.96
|
HIPPIE
|
11314018
14517242
14522994
10421843
19287004
29674694
10064597
18508766
9202126
9344848
11971965
11713228
29991678
28258213
10455112
|
RAF1
|
MAP2K1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.96
|
0.96
|
mint
|
7014125
19197339
|
SMAD1
|
SMAD4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
960.0
|
0.96
|
STRING
|
36370105
|
NANOG
|
POU5F1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
962.0
|
0.96
|
STRING
|
36370105
|
MAP2K1
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
963.0
|
0.96
|
STRING
|
36370105
|
IL6ST
|
LIF
|
â—¼ PHYSICAL_INTERACTION
|
|
|
967.0
|
0.96
|
STRING
|
36370105
|
APC
|
GSK3B
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
11166179
29045831
21118991
8638126
11251183
23602568
29568061
|
SOS1
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.97
|
0.97
|
mint
|
5220480
7642581
|
PIK3R1
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.97
|
0.97
|
mint
|
20018188
7383613
|
JAK1
|
STAT3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
11722592
15284024
11294897
8272872
11751884
11350938
12626508
12576423
11940572
10918587
12244095
8626374
9566874
25065853
31462771
14551213
|
AXIN2
|
CTNNB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
969.0
|
0.97
|
STRING
|
36370105
|
FGF2
|
FGFR2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
1697263
28514442
11121055
10950949
11390973
9700203
33961781
18199118
26267536
10830168
17981115
|
CTNNB1
|
GSK3B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
969.0
|
0.97
|
STRING
|
36370105
|
MAP2K1
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
971.0
|
0.97
|
STRING
|
36370105
|
KRAS
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
972.0
|
0.97
|
STRING
|
36370105
|
IGF1
|
IGF1R
|
â—¼ PHYSICAL_INTERACTION
|
|
|
973.0
|
0.97
|
STRING
|
36370105
|
MAP2K1
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
974.0
|
0.97
|
STRING
|
36370105
|
SKIL
|
SMAD4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
979.0
|
0.98
|
STRING
|
36370105
|
HRAS
|
RAF1
|
â—¼ PROXIMITY
|
✅
|
|
0.98
|
0.98
|
mint
|
18273062
6540139
|
RAF1
|
HRAS
|
â—¼ PROXIMITY
|
✅
|
|
0.98
|
0.98
|
mint
|
18273062
6540139
|
MAP2K2
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
984.0
|
0.98
|
STRING
|
36370105
|
PIK3CD
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
986.0
|
0.98
|
STRING
|
36370105
|
AXIN1
|
DVL2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
987.0
|
0.98
|
STRING
|
36370105
|
PIK3CA
|
PIK3R2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
987.0
|
0.98
|
STRING
|
36370105
|
HRAS
|
SOS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
989.0
|
0.99
|
STRING
|
36370105
|
POU5F1
|
SOX2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
992.0
|
0.99
|
STRING
|
36370105
|
AXIN1
|
CTNNB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
995.0
|
0.99
|
STRING
|
36370105
|
GRB2
|
SOS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
AXIN1
|
GSK3B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
APC
|
AXIN1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
26.0
|
1.0
|
ACSN
|
10421629
10581160
11487578
11955436
11967263
12051714
12554650
15001769
15327768
16039586
16288291
16940750
17143292
17318175
17936032
19619488
19751508
20006983
20705860
22270359
23343194
24023259
25730849
7542250
8638126
8666229
|
APC
|
CTNNB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
999.0
|
1.0
|
STRING
|
36370105
|
APC
|
AXIN1
|
â—¼ PROTEIN_INTERACTION
|
|
|
26.0
|
1.0
|
ACSN
|
10421629
10581160
11487578
11955436
11967263
12051714
12554650
15001769
15327768
16039586
16288291
16940750
17143292
17318175
17936032
19619488
19751508
20006983
20705860
22270359
23343194
24023259
25730849
7542250
8638126
8666229
|
MYC
|
APC
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
22911891
12695333
|
GSK3B
|
APC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
28.0
|
1.0
|
Omnipath
|
16944320
11166179
16799642
11967263
14663202
8524413
12554650
8638126
17910481
15327768
10581160
11487578
17318175
15465828
10228155
15020233
10421629
10698523
9832503
|
AXIN1
|
APC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
16199882
20128690
19131971
11297546
9554852
22682247
10228155
26496610
23277359
10811618
9734785
|
APC
|
CTNNB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
60.0
|
1.0
|
Omnipath
|
17145710
10545404
11166179
8259519
7890674
22083140
27902311
8638126
16212417
16798748
19061640
9286858
15327769
9482734
11533658
22056988
19576224
15327768
17318191
26496610
12628243
15355978
9065403
11712088
25241761
26910375
22682247
9065401
12000790
11707392
20219694
9707618
23840886
15525529
11251183
8628279
19631635
11972058
21664290
|
FGFR1
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
Reactome
|
17505008
18757403
21666749
11689702
11739186
18381441
19809159
21160078
14534538
15448205
|
FGFR4
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
Reactome
|
17505008
18757403
21666749
11689702
11739186
18381441
19809159
21160078
14534538
15448205
|
GRB2
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
54.0
|
1.0
|
ACSN
|
10086337
10567412
10811803
10843677
10982827
11034387
11062502
11385609
11447289
11532940
11777939
11907067
12040186
12175651
12419216
12479806
12566895
12640133
12782630
14585353
14764585
15169888
15516985
15536084
15547943
15567848
15574420
15735649
15863030
16102570
16227978
16488589
16582911
16887996
17178906
17395718
17496910
17673906
18039929
19289794
19449109
19541618
19565474
19568798
19615955
21102635
22435554
24027568
26552706
7510700
8551221
8929532
9069260
9510155
|
SOS1
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
1.0
|
1.0
|
HIPPIE
|
28514442
16520382
31980649
32062451
8493579
21988832
14679214
7510700
7514169
21706016
10319320
32203420
9872323
9797459
34407391
16906159
10716926
12577067
8810325
7629168
11960376
7664271
8626525
15192046
7629138
11997436
8943292
10207103
8695800
10570290
10025673
8112292
11726515
8816480
20473329
7559490
7773779
9447984
19380743
7642581
7527391
9716598
9344843
10477741
16713569
19323566
7516467
17474147
9569023
8188688
16893902
11964172
9478994
33961781
8479541
28166272
9009162
|
GRB2
|
RAF1
|
â—¼ SHARES_COMPLEX
|
|
|
54.0
|
1.0
|
ACSN
|
10086337
10567412
10811803
10843677
10982827
11034387
11062502
11385609
11447289
11532940
11777939
11907067
12040186
12175651
12419216
12479806
12566895
12640133
12782630
14585353
14764585
15169888
15516985
15536084
15547943
15567848
15574420
15735649
15863030
16102570
16227978
16488589
16582911
16887996
17178906
17395718
17496910
17673906
18039929
19289794
19449109
19541618
19565474
19568798
19615955
21102635
22435554
24027568
26552706
7510700
8551221
8929532
9069260
9510155
|
HRAS
|
GRB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
Reactome
|
19946327
11429702
11157491
18757403
21666749
21711248
18381441
19103595
21160078
9857065
20179196
|
KRAS
|
GRB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
Reactome
|
19946327
11429702
11157491
18757403
21666749
21711248
18381441
19103595
21160078
9857065
20179196
|
NRAS
|
GRB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
Reactome
|
19946327
11429702
11157491
18757403
21666749
21711248
18381441
19103595
21160078
9857065
20179196
|
GRB2
|
PIK3R1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
32.0
|
1.0
|
ACSN
|
10086337
10567412
10811803
10849428
10982827
11335727
11447289
11449354
11532940
11777939
12175651
12393695
12640133
15308668
15567848
15574420
16000375
16076871
16530705
16582911
16887996
17496910
17673906
18835194
19449109
19454690
22064427
22464172
24217602
25922287
26552706
8551221
|
GRB2
|
ITGB1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
26.0
|
1.0
|
ACSN
|
10086337
10426994
10567412
10811803
10982827
11447289
11777939
11777960
11907067
12175651
12640133
15536084
15567848
15574420
16339513
16582911
16713974
16887996
17070508
17100878
17496910
17673906
18490724
19449109
26552706
8551221
|
IL6ST
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
7963520
9013873
|
FGFR2
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
22726438
19735729
26103942
20554525
23420874
|
JAK2
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
8536716
8950973
7500025
17474147
19273609
|
GRB2
|
SOS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
145.0
|
1.0
|
Omnipath
|
9544989
9872323
7642581
15746962
11726515
8621483
23334917
16520382
11997436
21706016
10359574
8950973
7664271
16713569
16893902
16906159
21988832
19323566
9009162
10716926
11964172
7629168
9815779
10592173
9716598
8647802
28166272
7773778
7773779
18778683
8188688
10319320
8810325
9344843
23452850
11960376
8816480
10025673
7510700
8940013
12955078
9697839
12345678
10477741
8493579
8943292
12577067
7862167
9199344
8112292
7898932
10207103
8695800
19531499
10570290
7760801
20005866
19380743
9447984
8235613
8479540
7527391
14679214
8479541
17474147
7514169
7629138
|
GRB2
|
HRAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
17496910
16713569
17673906
11352655
|
NRAS
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
RAF1
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
25435214
20179705
20141835
16364920
20130576
15035987
25907612
|
HRAS
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
MAPK1
|
MAP2K2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
11802164
15239952
21779496
11802165
15260967
|
FGFR4
|
MAPK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
19652666
12419216
18452557
12974390
|
FGFR3
|
MAPK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
19652666
12419216
18452557
12974390
|
FGFR1
|
MAPK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
19652666
12419216
18452557
12974390
|
FGFR2
|
MAPK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
19652666
12419216
18452557
12974390
|
MAPK1
|
SMAD3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
10197981
16156666
27153775
29577978
|
MAPK1
|
SMAD2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
10197981
16156666
27153775
29577978
|
MYC
|
MAPK1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
22789855
21933022
16596619
23617883
8013639
20144848
|
MAP2K2
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
68.0
|
1.0
|
Omnipath
|
21675959
11704645
9694850
17081983
7565670
12750173
19690332
12932319
11823456
18799465
15592455
11337027
18083107
21365009
12788955
11134045
19219045
17389395
9447970
15342917
23331499
19534553
17569879
7559390
23047924
8226933
8223433
17272394
15851026
15811950
19494114
18988627
18669648
11549292
23519423
19541618
18691976
1381507
16293107
17906627
11986622
19933846
8376945
19053285
16094384
11971971
17192257
11136732
11948414
8388392
7898932
9731057
11730323
18039929
11118451
19369195
12920017
15951569
15466214
10746662
|
DUSP9
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
9030581
23331499
21908610
11988087
18296638
9922370
|
MAPK14
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
20.0
|
1.0
|
Omnipath
|
15187187
21675959
18039929
12738796
11157753
22521293
17255949
11238443
11274345
12697810
|
MAP2K1
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
149.0
|
1.0
|
Omnipath
|
21675959
9694850
17081983
10757792
11319218
18799465
15592455
12788955
19415658
12697810
17389395
9447970
15342917
8226933
15851026
12270934
12644307
17255949
10998418
11242034
1378617
1381507
17906627
11986622
8376945
8157000
7992057
11948414
9731057
19651622
11251083
11266467
18707149
14743221
11279118
11704645
12750173
12932319
16497976
11337027
23331499
12048245
7559390
17272394
15811950
19494114
18669648
18691976
11741894
15972258
19053285
16094384
17192257
7898932
24623782
9166761
19369195
21336309
12920017
15466214
17016520
19901323
1712480
19690332
11823456
9032297
11134045
12876277
19534553
10995751
20068231
21506533
8223433
8248196
16153436
12594221
10567369
19933846
17563371
11730323
29175850
11352917
16135787
15951569
19058874
15212693
23241949
9560161
91184134
18083107
16887817
18578522
17569879
21071413
9148935
18452278
1330321
8670897
19541618
10777511
15935618
12925710
11971971
9765155
11136732
11118451
12082107
12952943
10746662
21768338
|
MAPK13
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
12738796
18039929
11274345
15187187
|
MAPK1
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
12975377
23602568
16424009
19058874
23397142
21707490
|
MAPK1
|
GSK3B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
8.0
|
1.0
|
Omnipath
|
16039586
28646232
18451303
|
MAPK1
|
SMAD4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
12801888
|
MAPK1
|
SMAD2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
25.0
|
1.0
|
Omnipath
|
23331499
10197981
34504019
18775330
20659902
8226933
9620846
16156666
9604935
18988627
12193595
11027280
8388392
27153775
31995604
|
MAPK1
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
43.0
|
1.0
|
Omnipath
|
17081983
18767875
15849194
19690332
11409918
14654779
23331499
23180781
8226933
20068231
18988627
21917714
18669648
19541618
18691976
16407412
19933846
9922370
15664191
8388392
19651622
10801873
8349614
18775330
9604935
|
MAPK1
|
FGFR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
27342992
23405013
|
MAPK1
|
LIFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
8.0
|
1.0
|
Omnipath
|
30851421
7777512
|
MAPK1
|
STAT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
59.0
|
1.0
|
Omnipath
|
18448488
19413330
11335711
9343414
15465816
25584415
12576423
11350938
20068231
12681450
12763138
9872331
11780390
18491316
18669648
11404481
10521505
18691976
20058876
15979846
14551213
10446219
|
MAPK1
|
SMAD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
53.0
|
1.0
|
Omnipath
|
19218245
18032789
18729074
16156666
19914161
23331499
19914168
24080014
8226933
14512875
15520018
20736297
26497676
12193595
26297431
18988627
8388392
10197981
15241418
18775330
9604935
9380693
|
MAPK1
|
SOS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
23331499
10197981
8816480
9922370
8626428
|
MAPK1
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
17.0
|
1.0
|
Omnipath
|
10551811
17081983
8386367
17251036
91332050
17570479
1748630
7957875
27167001
15212693
1651323
15210690
|
MAPK1
|
SMAD1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
14.0
|
1.0
|
Omnipath
|
17289590
19914168
9335504
19914161
|
MAPK1
|
TCF3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
8.0
|
1.0
|
Omnipath
|
14592976
12810726
|
DUSP9
|
MAPK14
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
9.0
|
1.0
|
Omnipath
|
9030581
26186194
23602568
21908610
11988087
18296638
|
MAPK14
|
TCF3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
15719023
17570479
|
MAPK14
|
GSK3B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
8.0
|
1.0
|
Omnipath
|
26822034
17726008
21303975
18451303
|
MAPK14
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
18.0
|
1.0
|
Omnipath
|
15187187
21675959
18039929
12738796
23397142
11238443
11274345
12697810
|
MAPK14
|
MAP2K1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
15187187
18039929
12738796
11274345
12697810
|
MAPK14
|
STAT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
23331499
10201984
18691976
17502367
17570479
|
MAPK14
|
EZH2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
21902831
30022044
17570479
27494834
28067271
|
MAPK14
|
FGFR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
10.0
|
1.0
|
Omnipath
|
15187187
18039929
18411303
12738796
20626350
11274345
|
MAPK14
|
SMAD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
23331499
10197981
15241418
14512875
16156666
15520018
|
MAPK14
|
MAP2K2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
12738796
18039929
11274345
15187187
|
KRAS
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
NRAS
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
HRAS
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
RAF1
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
25435214
20179705
20141835
16364920
20130576
15035987
25907612
|
MAPK3
|
MAP2K2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
11802164
15239952
21779496
11802165
15260967
|
FGFR4
|
MAPK3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
19652666
12419216
18452557
12974390
|
FGFR1
|
MAPK3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
19652666
12419216
18452557
12974390
|
FGFR3
|
MAPK3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
19652666
12419216
18452557
12974390
|
FGFR2
|
MAPK3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
19652666
12419216
18452557
12974390
|
MAPK3
|
SMAD2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
10197981
16156666
27153775
29577978
|
MAPK3
|
SMAD3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
10197981
16156666
27153775
29577978
|
MAPK11
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
12738796
18039929
11274345
15187187
|
MAP2K2
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
101.0
|
1.0
|
Omnipath
|
19901323
17081983
11704645
9694850
12750173
1411546
19690332
12932319
18799465
16497976
18083107
11134045
8626767
9006895
17389395
19219045
15342917
9447970
16887817
23331499
17569879
7867743
7559390
21071413
19534553
8226933
20068231
8223433
17272394
93330262
15851026
15811950
26987942
18988627
19494114
18669648
19541618
11242034
15466476
18691976
1381507
17906627
11986622
19933846
8376945
11971971
17192257
11136732
11948414
7898932
7687743
9731057
19651622
11730323
16464493
18983981
11251083
11118451
15580310
19369195
18707149
12920017
15951569
15466214
10746662
15212693
|
MAP2K1
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
106.0
|
1.0
|
Omnipath
|
9694850
17081983
11319218
18799465
17389395
9447970
15342917
8226933
15851026
12270934
12644307
11242034
1381507
17906627
9677429
11986622
8376945
7992057
11948414
7687743
9731057
19197339
11704645
7565670
12750173
12932319
8626767
23331499
12048245
7559390
17272394
15811950
26987942
19494114
18669648
18691976
17192257
8388392
7898932
16464493
19369195
12920017
15466214
19690332
11134045
19534553
10995751
7867743
8223433
8248196
10567369
19933846
17563371
1518847
11730323
18983981
16186792
16135787
15951569
19058874
15212693
10748187
9560161
9925641
9733512
18083107
11104681
9006895
17569879
21071413
7731720
1330321
93330262
19541618
15466476
12925710
11971971
11136732
11118451
10746662
|
DUSP9
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
9030581
23331499
25241761
21908610
11988087
18296638
9922370
|
MAPK13
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
12738796
18039929
11274345
15187187
|
MAPK3
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
23331499
18463697
9155018
21071413
32482868
18988627
15210690
|
MAPK3
|
SMAD2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
47.0
|
1.0
|
Omnipath
|
17081983
16156666
19413330
11027280
9620846
33676893
23331499
8226933
20068231
18988627
12193595
18491316
18691976
8388392
19651622
10197981
18775330
19115199
9604935
15212693
|
MAPK3
|
STAT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
73.0
|
1.0
|
Omnipath
|
18448488
19413330
11335711
9343414
23331499
15465816
25584415
12576423
11350938
20068231
12681450
10417333
12763138
9872331
18988627
11780390
18491316
18669648
11404481
10521505
18691976
19723038
20058876
14551213
10446219
|
MAPK3
|
SMAD1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
23331499
10197981
9335504
|
MAPK3
|
FGFR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
27342992
23405013
18411303
|
MAPK3
|
SMAD4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
28115363
12801888
|
MAPK3
|
SMAD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
23331499
10197981
15241418
24080014
18775330
8226933
16156666
9604935
12193595
8388392
|
MAPK3
|
LIFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
10.0
|
1.0
|
Omnipath
|
18624908
30851421
7777512
28122243
22306348
|
MAPK3
|
TCF3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
9.0
|
1.0
|
Omnipath
|
14592976
|
MAPK3
|
SOS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
29145629
7478566
23331499
8816480
7739560
17570479
9922370
|
MAPK3
|
GSK3B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
16039586
28646232
|
MAPK3
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
14654779
23331499
19541618
18691976
16407412
19933846
9446616
9922370
15664191
18988627
|
MYC
|
AXIN1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
22.0
|
1.0
|
ACSN
|
11274345
11283614
16713974
16940750
17558397
17873522
19131971
19366350
19751508
19836308
20027199
20237412
20551172
20581311
20713526
21406394
2191300
22067385
22270359
23732914
25002027
26885856
|
MYC
|
AXIN1
|
â—¼ SHARES_COMPLEX
|
|
|
22.0
|
1.0
|
ACSN
|
11274345
11283614
16713974
16940750
17558397
17873522
19131971
19366350
19751508
19836308
20027199
20237412
20551172
20581311
20713526
21406394
2191300
22067385
22270359
23732914
25002027
26885856
|
STAT3
|
MYC
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
33.0
|
1.0
|
ACSN
|
10347215
11875494
12193690
12223527
12907458
14607900
14670306
15218058
15356132
15465827
15573129
16418395
17404308
18776941
19380816
20093776
20237412
20406969
20435894
20580461
20581311
21372296
21765015
21840487
22461508
23124025
23390297
23454751
23953057
24857661
27216177
28186502
7543512
|
MYC
|
BMI1
|
â—¼ UP_REGULATES
|
✅
|
+
|
32.0
|
1.0
|
ACSN
|
11274345
11283614
12545156
14536078
15147722
15155580
15279786
17055429
17303408
17550342
17558397
17660363
17873522
18590585
18636226
20027199
20237412
20551172
20581311
20713526
20818389
21406394
21733352
2191300
21919891
22067385
23140366
23869868
25002027
28536364
7575488
9618481
|
STAT3
|
MYC
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
19289167
17204573
18184402
22317895
20067773
15184887
15469392
10464281
9325164
20654581
21573184
17959148
22349830
9874564
20581311
19259613
|
SMAD4
|
MYC
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
11689553
17132729
|
CTNNB1
|
MYC
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
21533051
19778454
16510874
12095419
17360646
18852287
15576399
19561604
20300972
19662654
15579438
17724465
9727977
24447505
18679417
12907606
|
SMAD3
|
MYC
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
9.0
|
1.0
|
Omnipath
|
15930298
20516082
14993291
17132729
16205635
25238097
11689553
17114344
|
MYC
|
WNT2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
19609274
22710352
17485441
20945354
19149881
|
MYC
|
ITGB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
11381265
16878156
12695333
|
MYC
|
ID2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
12447693
12695333
12824180
18437010
18483244
12545167
|
MYC
|
ID3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
22564737
12695333
|
TCF3
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
22.0
|
1.0
|
Omnipath
|
19751508
7542250
11967263
22290435
19623618
23343194
11955436
22270359
22761862
16039586
15810077
17143292
12051714
8666229
22943793
15576399
21151179
16940750
17306568
17666529
21285352
19619488
|
TCF7
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
17306568
17666529
23343194
21285352
15576399
21151179
22761862
22290435
16039586
19619488
19623618
17143292
|
GSK3B
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
73.0
|
1.0
|
Omnipath
|
17081983
18463697
21646472
30037819
26751215
25647305
2663470
20080742
19797085
30003124
16855632
12040186
18679417
11018017
23331499
29229669
16611981
21071413
24265759
20068231
10671551
16039586
17570479
16023596
29258530
12615961
18669648
21113395
22461507
19131971
8247524
16247449
20604938
19575820
15150404
22481935
23668310
19651622
17444818
23964270
20537194
22893788
27684546
24662831
25333250
20399964
11877389
14563837
18408012
17052453
18455992
15212693
16371461
11274345
|
CTNNB1
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
23.0
|
1.0
|
Omnipath
|
19751508
7542250
11967263
22290435
19623618
16574648
23343194
11955436
22270359
22761862
16039586
15810077
17143292
12051714
8666229
22943793
15576399
21151179
16940750
17306568
17666529
21285352
19619488
|
DVL3
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
29.0
|
1.0
|
Omnipath
|
15806138
16510874
22290435
18627596
19623618
11929833
23343194
15768032
22761862
17050667
16039586
20122174
17291450
20920541
17143292
20006983
17439715
15576399
21767405
23306204
8545107
22705350
18347071
16007074
16169192
21285352
20530697
19619488
11274345
|
MYC
|
SMAD2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
23331499
11804592
|
MYC
|
SMAD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
23331499
11804592
|
NRAS
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
31135801
24897931
8665852
17998941
11136978
21779505
8052307
12121613
1716764
26085527
21779497
12094235
|
FGFR4
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
Reactome
|
17505008
18757403
21666749
11689702
11739186
18381441
19809159
21160078
14534538
15448205
|
PIK3CA
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
999.0
|
1.0
|
STRING
|
36370105
|
KRAS
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
31135801
24897931
8665852
17998941
11136978
21779505
8052307
12121613
1716764
26085527
21779497
12094235
|
FGFR3
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11353842
9632781
14534538
9182757
|
STAT3
|
PIK3R1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
11733515
24218138
23963458
15793565
16293640
|
HRAS
|
PIK3R1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
9069260
25241761
10212255
11313862
9150145
16713569
15021914
|
JAK1
|
PIK3R1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
9774657
15021914
7544789
|
IGF1R
|
PIK3R1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
8603569
17496910
25241761
8697095
7642582
17570479
18595745
7589433
|
JAK2
|
PIK3R1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
8702385
12706299
16135792
17474147
|
CTNNB1
|
PIK3R1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
10477752
25241761
16219695
11716761
|
FGFR1
|
PIK3R1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
17496910
18412956
25241761
15117958
|
PIK3R1
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
10527852
16799564
19442713
|
PIK3R1
|
PIK3CB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
8596638
25241761
20713702
27107012
11733063
21825134
32814053
26496610
8139559
14729945
10358930
14665640
|
PIK3R1
|
PIK3CD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
9113989
8596638
21827948
12147247
11733063
22020336
24165795
31031754
14665640
|
PIK3R1
|
SOS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
17474147
19531499
25241761
|
SKIL
|
SMAD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
25.0
|
1.0
|
Omnipath
|
12764135
23331499
21071413
22442258
11306568
16959829
10531062
12793438
17469184
15231748
11691834
12426322
|
SKIL
|
SMAD4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
23.0
|
1.0
|
Omnipath
|
12764135
25609649
23331499
25059663
15761153
10531062
17510063
12793438
17469184
15231748
|
SKIL
|
SMAD2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
31.0
|
1.0
|
Omnipath
|
12764135
15221015
23331499
18729074
22442258
25059663
16959829
18334480
10531062
17510063
15496141
12793438
15231748
11691834
12426322
|
STAT3
|
POU5F1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
19151334
20505821
15277698
18212089
17068183
|
STAT3
|
JAK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
11418623
12517932
12244150
27774606
12093291
12759422
|
LIFR
|
STAT3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
7.0
|
1.0
|
ACSN
|
11306493
19833085
21840487
22595692
24857661
7512720
7521688
|
JAK1
|
STAT3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
15.0
|
1.0
|
ACSN
|
10426994
11907067
12244150
12811837
15536084
16081783
16713974
16785506
19833085
20856220
21840487
23124025
24751819
7512720
7521688
|
LIF
|
STAT3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
7.0
|
1.0
|
ACSN
|
11306493
19833085
21840487
22595692
24857661
7512720
7521688
|
JAK2
|
STAT3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
12.0
|
1.0
|
ACSN
|
11867689
14610620
19833085
20237318
20406969
20581311
21840487
22754783
24091328
27216177
7512720
7521688
|
STAT3
|
FGF2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
33.0
|
1.0
|
ACSN
|
10347215
11875494
12193690
12223527
12907458
14607900
14670306
15218058
15356132
15465827
15573129
16418395
17404308
18776941
19380816
20093776
20237412
20406969
20435894
20580461
20581311
21372296
21765015
21840487
22461508
23124025
23390297
23454751
23953057
24857661
27216177
28186502
7543512
|
STAT3
|
SOCS1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
18843197
14630083
16432158
20003295
20357037
10809230
|
IL6ST
|
STAT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
8.0
|
1.0
|
Omnipath
|
12040451
12361954
8272872
18060032
|
JAK1
|
STAT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
121.0
|
1.0
|
Omnipath
|
18691551
20169197
19901323
12626585
12759422
15805299
10918587
9305919
15261459
21420464
8272872
10851062
12093291
17878297
12626508
12351624
12040185
16497976
15592455
20966397
8662928
18941194
17389395
23331499
11306517
8756628
12576423
11350938
12244150
18669613
7796300
11294897
24710148
11163236
11722592
11418623
8085155
12244095
21690253
14764663
9535918
21098725
9083098
8662591
22905257
14565860
27774606
8626374
19723038
29145629
26260587
9566874
24501689
25297818
9651359
11940572
11429593
11564763
12517932
14551213
8662795
19535621
23124025
18389480
15284024
11706020
11850821
17016520
9582023
17595657
|
MAP2K1
|
STAT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
9305919
7719937
7568001
10602027
12681450
7719938
7544001
7528668
|
JAK3
|
STAT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
23331499
10037026
23109003
11406370
12495636
16189514
12207328
10825200
12934099
18988627
30029643
|
JAK2
|
STAT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
167.0
|
1.0
|
Omnipath
|
10918587
8272872
16319070
18718905
15592455
34066153
23166634
33986510
17389395
29162862
29449694
33512408
21098725
9083098
17565041
27748760
27344175
34031055
29290793
21285325
33846242
33774038
9566874
25962054
20826784
14551213
26188635
26008966
15284024
26175413
21481791
33774344
26307676
9305919
10925297
15615703
12626508
16497976
32087696
16469875
31914141
23331499
11350938
28978186
16306356
33824475
18988627
17401459
19147545
15151905
12637586
34433042
8626374
15950906
27181202
24793791
20455003
21575192
32094172
15322111
17016520
34247191
19901323
12626585
27086926
21166956
23906537
31976162
9211920
12576423
22306293
10207096
12075083
11294897
26787900
12244095
14701810
33909625
11803465
17360477
28827891
33820781
19159681
18939995
11445068
27941883
11429593
30054295
26675255
11850821
9582023
34067421
34707127
15786731
25986861
27351213
34118143
15077188
26699492
12595539
21071413
18498667
22153071
15156153
33513694
25915428
11940572
12529382
18525315
24501689
33839684
24316223
19834108
9575217
|
FGFR3
|
STAT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
54.0
|
1.0
|
Omnipath
|
19901323
10918587
9305919
8272872
12626508
16497976
15592455
17389395
12576423
11350938
11294897
12244095
9083098
8626374
9566874
11940572
11429593
14551213
11850821
17016520
9582023
|
MAP2K2
|
STAT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
17142955
9305919
7719937
7568001
10602027
12681450
7719938
7544001
7528668
|
FGFR4
|
STAT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
54.0
|
1.0
|
Omnipath
|
19901323
10918587
9305919
8272872
12626508
16497976
15592455
17389395
12576423
11350938
11294897
12244095
9083098
8626374
9566874
11940572
11429593
14551213
11850821
17016520
9582023
|
STAT3
|
WNT5A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
19424602
17203201
|
FZD7
|
WNT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
Reactome
|
10862746
20006983
17433286
23396967
15143170
15169958
21316585
16495441
20940229
23140633
|
DVL2
|
WNT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
AXIN1
|
WNT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11336703
17529994
18077588
17569865
|
DVL1
|
WNT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
WNT1
|
DVL3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
WNT1
|
GSK3B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11336703
17529994
18077588
17569865
|
WNT1
|
FZD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
Reactome
|
11448771
11029007
15459103
12205098
22000856
22653731
11357136
15084453
23256519
23791946
|
WNT1
|
FZD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
Reactome
|
10862746
20006983
17433286
23396967
15143170
15169958
21316585
16495441
20940229
23140633
|
WNT1
|
CTNNB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
33.0
|
1.0
|
Omnipath
|
21108734
7641885
15265686
19718039
21602792
210606194
8655584
19705439
19029934
20093472
17430994
21606194
17884187
14747478
16554443
18936100
22017973
22433869
17143292
20006983
19072724
14704854
16965538
16443747
22007144
16547521
19020754
20940130
21640127
21087212
17127310
15208637
21796133
|
WNT1
|
FZD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
14642436
15578921
|
WNT1
|
FZD8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
15454084
1545408415454080
11448771
|
WNT1
|
FZD9
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
91476519147651
9147651
|
WNT1
|
FZD1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
10557084
22944199
15578921
16936075
24032637
|
DVL2
|
FZD7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
11.0
|
1.0
|
Reactome
|
23821037
15936275
10698942
9716412
17130287
9674432
17627283
11358862
11101902
12015986
14636582
|
FZD7
|
WNT11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
Reactome
|
10862746
20006983
17433286
23396967
15143170
15169958
21316585
16495441
20940229
23140633
|
WNT2
|
FZD7
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
23815780
|
WNT11
|
FZD7
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
10862746
|
WNT3A
|
FZD7
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
18215320
|
WNT3
|
FZD7
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
25892522
18313787
24032637
|
WNT5A
|
FZD7
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
10990458
|
CTNNB1
|
AXIN2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
24447505
15473860
11809809
22615875
11809808
12711682
11940574
|
TCF3
|
AXIN2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
19751508
7542250
8666229
11955436
11967263
22270359
16940750
12051714
|
CTNNB1
|
AXIN2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
17.0
|
1.0
|
Omnipath
|
10966653
19751508
7542250
8666229
17143292
11955436
11967263
23343194
22270359
9554852
22699938
16039586
16940750
9566905
19619488
15766563
12051714
|
AXIN2
|
GSK3B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
15611123
10966653
10911903
888800000547
9554852
22745173
9566905
22322943
|
ID3
|
TCF3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
13.0
|
1.0
|
Omnipath
|
9242638
22354994
11175815
12614353
15016815
10915743
9525934
8759016
|
WNT7A
|
FZD10
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
12857724
18567805
|
WNT7B
|
FZD10
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
15923619
|
CTNNB1
|
ID2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
15252039
19751508
7542250
17615296
8666229
11708773
11967263
11955436
22270359
16940750
12051714
15181457
|
SMAD3
|
SMAD4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
999.0
|
1.0
|
STRING
|
36370105
|
SMAD2
|
SMAD4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
999.0
|
1.0
|
STRING
|
36370105
|
SMAD4
|
SMAD3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
72.0
|
1.0
|
ACSN
|
10454538
10925299
10964912
11007770
11013125
11013220
11074002
11114293
11224571
11279127
11283613
11283614
11376132
11399519
11792802
11875494
12193690
12545156
12702545
12809600
14976548
15001984
15095404
15155580
15265520
15644117
16127449
16179589
16713975
16831886
17018611
17055429
17260466
17550342
17563753
17689680
17705132
18353785
18768831
18832382
19208835
19597490
19815509
19901969
20027199
20713526
20731704
21041997
21042762
21098712
21252118
21317430
21577210
21614932
2191300
22331441
22514743
22652804
23140366
23338822
23390297
23784029
23869868
25374926
6357187
8515656
8871614
8893010
9312026
9389648
9618481
9670020
|
SMAD4
|
SMAD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
52.0
|
1.0
|
ACSN
|
10454538
10925299
10964912
11007770
11013220
11074002
11279127
11283613
11283614
11399519
11792802
11875494
12193690
12545156
12702545
12809600
15001984
15095404
15155580
15265520
15644117
16127449
16179589
16713975
17055429
17260466
17550342
17689680
17705132
18353785
18768831
19815509
19901969
20027199
20713526
21042762
21252118
21614932
2191300
22331441
23140366
23338822
23390297
23784029
23869868
6357187
8515656
8871614
9312026
9389648
9618481
9670020
|
SMAD4
|
SMAD3
|
â—¼ PROTEIN_INTERACTION
|
|
|
72.0
|
1.0
|
ACSN
|
10454538
10925299
10964912
11007770
11013125
11013220
11074002
11114293
11224571
11279127
11283613
11283614
11376132
11399519
11792802
11875494
12193690
12545156
12702545
12809600
14976548
15001984
15095404
15155580
15265520
15644117
16127449
16179589
16713975
16831886
17018611
17055429
17260466
17550342
17563753
17689680
17705132
18353785
18768831
18832382
19208835
19597490
19815509
19901969
20027199
20713526
20731704
21041997
21042762
21098712
21252118
21317430
21577210
21614932
2191300
22331441
22514743
22652804
23140366
23338822
23390297
23784029
23869868
25374926
6357187
8515656
8871614
8893010
9312026
9389648
9618481
9670020
|
SMAD4
|
SMAD2
|
â—¼ PROTEIN_INTERACTION
|
|
|
52.0
|
1.0
|
ACSN
|
10454538
10925299
10964912
11007770
11013220
11074002
11279127
11283613
11283614
11399519
11792802
11875494
12193690
12545156
12702545
12809600
15001984
15095404
15155580
15265520
15644117
16127449
16179589
16713975
17055429
17260466
17550342
17689680
17705132
18353785
18768831
19815509
19901969
20027199
20713526
21042762
21252118
21614932
2191300
22331441
23140366
23338822
23390297
23784029
23869868
6357187
8515656
8871614
9312026
9389648
9618481
9670020
|
SMAD4
|
FGF2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
20.0
|
1.0
|
ACSN
|
11013125
11074002
11279127
11376132
11792802
12702545
12809600
15265520
16179589
16713975
18768831
21042762
21098712
21614932
22331441
22652804
23784029
25374926
8515656
9389648
|
SMAD4
|
ID1
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
13.0
|
1.0
|
ACSN
|
11074002
11279127
11792802
12702545
12809600
15265520
16713975
16831886
17490644
18832382
21614932
23850759
9389648
|
SMAD4
|
SMAD3
|
â—¼ LOCALISATION
|
✅
|
|
72.0
|
1.0
|
ACSN
|
10454538
10925299
10964912
11007770
11013125
11013220
11074002
11114293
11224571
11279127
11283613
11283614
11376132
11399519
11792802
11875494
12193690
12545156
12702545
12809600
14976548
15001984
15095404
15155580
15265520
15644117
16127449
16179589
16713975
16831886
17018611
17055429
17260466
17550342
17563753
17689680
17705132
18353785
18768831
18832382
19208835
19597490
19815509
19901969
20027199
20713526
20731704
21041997
21042762
21098712
21252118
21317430
21577210
21614932
2191300
22331441
22514743
22652804
23140366
23338822
23390297
23784029
23869868
25374926
6357187
8515656
8871614
8893010
9312026
9389648
9618481
9670020
|
SMAD2
|
SMAD4
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
16052471
11376804
11456453
9812998
|
SMAD3
|
SMAD4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
104.0
|
1.0
|
Omnipath
|
25609649
9843571
15084259
20211142
21532621
24584437
18729074
23788427
12419246
18923419
9892009
19768112
10531362
15231748
9679060
12167862
21988832
12150994
23331499
12543979
18568018
21071413
19135894
15467747
25502805
9732876
11927552
16189514
12917407
25514493
15350224
10995777
18988627
10092624
12732634
25910212
10878024
9111321
20564330
27107012
9311995
12957874
20142324
11114293
32296183
15588252
15761153
24157709
26555259
29892012
17469184
22442258
16714330
21597466
15922743
22045334
17591701
24382352
22310290
19139564
19917253
29997244
31515488
28115363
10942775
21297662
17283070
12794086
|
SMAD5
|
SMAD4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
20957627
23331499
14534577
16516194
16189514
10531362
15231748
|
SMAD2
|
SMAD4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
110.0
|
1.0
|
Omnipath
|
15613484
17145710
25609649
15817471
20211142
21532621
24584437
18729074
23788427
12419246
16916642
9288972
9892009
21454478
17510063
10531362
15231748
11027280
12167862
21988832
9389648
23331499
12543979
18568018
21071413
19135894
18511908
15467747
12808092
11927552
25514493
15350224
18988627
12732634
10878024
9111321
9311995
9346908
10199400
11264182
12957874
11114293
15761153
11274206
12621041
17272273
24157709
26555259
12374795
22442258
10781087
15922743
11102446
17591701
18783722
16751102
19139564
19917253
9346966
21297662
17283070
12794086
|
SMAD1
|
SMAD4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
34.0
|
1.0
|
Omnipath
|
17183365
9436979
24412244
11779505
31467278
21454478
10531362
15231748
12167862
23331499
21071413
11700304
12874272
16189514
18988627
20957627
9111321
15761153
32296183
26555259
14701756
14534577
|
SMAD9
|
SMAD4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
20957627
25502805
10583507
31515488
16189514
15231748
|
SMAD4
|
ID1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
9389648
18832382
16831886
11074002
17490644
|
JAK1
|
LIFR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
ACSN
|
11306493
19833085
21840487
22595692
24857661
7512720
7521688
|
JAK1
|
LIF
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
ACSN
|
11306493
19833085
21840487
22595692
24857661
7512720
7521688
|
JAK1
|
JAK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
92.0
|
1.0
|
ACSN
|
10485906
11160275
11306493
11371360
11489965
11579131
11777960
11867689
11870632
11964313
12223527
12401408
12413632
12496409
12754507
12811837
12818165
1439146
14607900
14610620
14657224
15099563
15356132
15573129
15634932
15778339
15811952
15814715
16243976
16286920
16413922
16424049
16713974
17016554
17404308
17485448
17559085
17683974
18209571
18250477
1825141
18272812
18451175
18555777
18555778
19581928
19833085
20038811
20138012
20184663
20237318
20406969
20510870
20581311
20819927
20856220
21097505
21115385
21149606
21411734
21469115
21840487
22595692
22754783
23034983
23124025
23390297
23567181
24011634
24030977
24091328
24346288
24418198
24658051
25002027
25582338
26201938
26268945
26755705
27216177
27557510
2965306
6425450
7512720
7521688
7543512
7590867
8837607
9535722
9834059
9845545
9864217
|
JAK1
|
IL6ST
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
8390097
9238703
16051226
11943154
|
JAK1
|
LIF
|
â—¼ SHARES_COMPLEX
|
|
|
7.0
|
1.0
|
ACSN
|
11306493
19833085
21840487
22595692
24857661
7512720
7521688
|
JAK1
|
JAK2
|
â—¼ SHARES_COMPLEX
|
|
|
92.0
|
1.0
|
ACSN
|
10485906
11160275
11306493
11371360
11489965
11579131
11777960
11867689
11870632
11964313
12223527
12401408
12413632
12496409
12754507
12811837
12818165
1439146
14607900
14610620
14657224
15099563
15356132
15573129
15634932
15778339
15811952
15814715
16243976
16286920
16413922
16424049
16713974
17016554
17404308
17485448
17559085
17683974
18209571
18250477
1825141
18272812
18451175
18555777
18555778
19581928
19833085
20038811
20138012
20184663
20237318
20406969
20510870
20581311
20819927
20856220
21097505
21115385
21149606
21411734
21469115
21840487
22595692
22754783
23034983
23124025
23390297
23567181
24011634
24030977
24091328
24346288
24418198
24658051
25002027
25582338
26201938
26268945
26755705
27216177
27557510
2965306
6425450
7512720
7521688
7543512
7590867
8837607
9535722
9834059
9845545
9864217
|
JAK1
|
LIFR
|
â—¼ SHARES_COMPLEX
|
|
|
7.0
|
1.0
|
ACSN
|
11306493
19833085
21840487
22595692
24857661
7512720
7521688
|
SOCS1
|
JAK1
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
6.0
|
1.0
|
ACSN
|
10485906
12193701
12223527
12811837
21469115
23124025
|
JAK1
|
INHBA
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
32.0
|
1.0
|
ACSN
|
10485906
11867689
12223527
12401408
14610620
14657224
15099563
16243976
16413922
17404308
17485448
18250477
18451175
19833085
20184663
20406969
20510870
20856220
21097505
21115385
21469115
21840487
23124025
23390297
24030977
24091328
26755705
27216177
7512720
7521688
7543512
9535722
|
IL6ST
|
JAK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
7896787
23331499
11468294
9388212
21220115
24710148
11742534
23663276
12487370
|
JAK3
|
JAK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
20.0
|
1.0
|
Omnipath
|
11641425
19901323
20135364
17259970
12207328
10825200
11909529
15659558
12559972
9553136
|
SOCS1
|
JAK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
19.0
|
1.0
|
Omnipath
|
23331499
10950967
12223527
10485906
26192618
10707961
12193701
18988627
10201892
10856136
21469115
23663276
11133764
23124025
12811837
9202126
|
JAK1
|
PIK3R2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
9774657
15021914
|
SMAD3
|
SMAD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
41.0
|
1.0
|
ACSN
|
10454538
10964912
11007770
11013220
11074002
11279127
11283613
11283614
11792802
12545156
12702545
12809600
15001984
15095404
15155580
15265520
16179589
16713975
17055429
17550342
17705132
18353785
18768831
19815509
19901969
20027199
20713526
21042762
21252118
21614932
2191300
22331441
23140366
23338822
23869868
8515656
9312026
9389648
9618481
9670020
9865696
|
SMAD3
|
SMAD2
|
â—¼ PROTEIN_INTERACTION
|
|
|
41.0
|
1.0
|
ACSN
|
10454538
10964912
11007770
11013220
11074002
11279127
11283613
11283614
11792802
12545156
12702545
12809600
15001984
15095404
15155580
15265520
16179589
16713975
17055429
17550342
17705132
18353785
18768831
19815509
19901969
20027199
20713526
21042762
21252118
21614932
2191300
22331441
23140366
23338822
23869868
8515656
9312026
9389648
9618481
9670020
9865696
|
ACVR1B
|
SMAD2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
23331499
9346908
11389842
9892009
18988627
14517293
|
SMAD2
|
SMAD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
21988832
26186194
12543979
9111321
15084259
9311995
25878769
18729074
12700238
|
SMAD3
|
FGF2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
20.0
|
1.0
|
ACSN
|
11013125
11074002
11279127
11376132
11792802
12702545
12809600
15265520
16179589
16713975
18768831
21042762
21098712
21614932
22331441
22652804
23784029
25374926
8515656
9389648
|
DVL1
|
SMAD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
23331499
15888125
12650946
15955531
|
AXIN1
|
SMAD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
11438668
23331499
18988627
|
AKT1
|
SMAD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
23331499
25241761
15104092
16362038
21071413
18988627
26297431
15048128
|
GSK3B
|
SMAD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
23331499
18172167
21071413
21310903
23077590
28756206
19114991
19002158
|
LIF
|
LIFR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
ACSN
|
11306493
19833085
21840487
22595692
24857661
7512720
7521688
|
LIF
|
LIFR
|
â—¼ SHARES_COMPLEX
|
|
|
7.0
|
1.0
|
ACSN
|
11306493
19833085
21840487
22595692
24857661
7512720
7521688
|
LIF
|
IL6ST
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
17145710
971648712707269
14527405
12707269
10811661
16051226
9143707
9716487
|
LIF
|
LIFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
33.0
|
1.0
|
Omnipath
|
19833085
7521688
23331499
24710148
12601009
11306493
9852103
24857661
7512720
16051226
9143707
9716487
8999038
10428964
21840487
22595692
26192618
8662595
|
JAK2
|
IL6ST
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
8390097
9238703
16051226
11943154
|
JAK2
|
LIFR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
8390097
9238703
16051226
11943154
|
SOCS1
|
JAK2
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
6.0
|
1.0
|
ACSN
|
10485906
12193701
12223527
12811837
21469115
23124025
|
JAK2
|
INHBA
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
32.0
|
1.0
|
ACSN
|
10485906
11867689
12223527
12401408
14610620
14657224
15099563
16243976
16413922
17404308
17485448
18250477
18451175
19833085
20184663
20406969
20510870
20856220
21097505
21115385
21469115
21840487
23124025
23390297
24030977
24091328
26755705
27216177
7512720
7521688
7543512
9535722
|
IL6ST
|
JAK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
23331499
7896787
8174677
9716487
|
SOCS1
|
JAK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
33.0
|
1.0
|
Omnipath
|
10421843
23331499
21071413
10455112
14522994
10064597
28258213
19287004
18508766
11314018
18988627
11971965
11713228
10975987
9202126
9344848
|
JAK2
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
18.0
|
1.0
|
Omnipath
|
11134016
8876196
9689060
10205168
|
JAK2
|
EZH2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
8.0
|
1.0
|
Omnipath
|
27468692
27494834
25038756
24469040
30159126
|
HRAS
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
999.0
|
1.0
|
STRING
|
36370105
|
RAF1
|
HRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
14.0
|
1.0
|
ACSN
|
10358164
11532940
12566895
14764585
15516985
16102570
19289794
19565474
24027568
7510700
8551221
9069260
9763606
9846483
|
RAF1
|
HRAS
|
â—¼ SHARES_COMPLEX
|
|
|
14.0
|
1.0
|
ACSN
|
10358164
11532940
12566895
14764585
15516985
16102570
19289794
19565474
24027568
7510700
8551221
9069260
9763606
9846483
|
RAF1
|
HRAS
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
14.0
|
1.0
|
ACSN
|
10358164
11532940
12566895
14764585
15516985
16102570
19289794
19565474
24027568
7510700
8551221
9069260
9763606
9846483
|
KRAS
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
53.0
|
1.0
|
Omnipath
|
10958680
12750173
9516156
12932319
9665134
10783161
8805624
1386920
1639773
8340422
8601312
19595761
23331499
16041367
21071413
8332195
9446616
10882715
25852190
10531446
1996324
19029954
8503013
16093354
19541618
23153539
16293107
1708096
19933846
26721396
11136732
10205168
20802526
31980649
7760835
18775988
8307946
12917261
11134016
20080631
8180183
1990291
|
AKT1
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
51.0
|
1.0
|
Omnipath
|
19197339
11971957
18767875
20230923
10576742
20068231
17570479
16189514
18669648
25241761
18691976
10576741
10618391
20688159
21745501
12087097
12801936
12048182
22798428
16854453
19058874
11997508
|
HRAS
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
147.0
|
1.0
|
Omnipath
|
17145710
18273062
9523700
1639773
8601312
19595761
20133694
11032808
9154803
10882715
14654780
1996324
19222999
16301319
11948414
8530446
7969158
11313862
9150145
20080631
1990291
12750173
15031288
12932319
9665134
8805624
8340422
1386920
23331499
16916524
16041367
23180781
18988627
20178605
15688026
15664191
22169110
11733498
7862125
8180183
19063885
12391160
9144171
8035810
9020159
14724584
19696784
21779497
9261098
12173045
12620389
8628317
19914712
1708096
19933846
26721396
7730360
10205168
8332187
16803888
18775988
12917261
9099670
10545207
25684575
8670882
10783161
12379659
10887184
17569879
21071413
8332195
7523381
10531446
24929361
8503013
16093354
19541618
10369681
8911690
18073111
11136732
10922060
7760835
11134016
|
NRAS
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
46.0
|
1.0
|
Omnipath
|
9867809
12750173
12932319
9001246
9665134
8805624
1386920
1639773
8340422
8601312
19595761
23331499
21071413
8332195
10531446
10882715
7811320
1996324
18988627
21779497
8636091
8503013
7766599
16093354
19541618
8180183
1708096
19933846
32296183
9525741
8876196
11136732
10205168
21478863
7760835
18775988
12917261
11134016
18641128
20080631
9488663
1990291
|
RAF1
|
MAP2K2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
47.0
|
1.0
|
Omnipath
|
7565670
12750173
18799465
16364241
11909642
19219045
21988832
23331499
15342917
8933152
9671314
8393135
9808624
8223433
16189514
18988627
18669648
19541618
16293107
10969079
10567369
8157000
11136732
11948414
7898932
9069260
18039929
19369195
8607979
10327068
17116858
24746704
12920017
16129686
19058874
15466214
|
RAF1
|
MAP2K1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
143.0
|
1.0
|
Omnipath
|
10757792
18337766
18799465
15342917
23728975
26496610
15866172
17053865
11242034
9351825
9677429
8157000
7992057
11948414
11604401
16129686
10677502
12695496
19197339
7565670
12750173
7936666
1326789
19219045
23331499
18556463
10976102
18988627
15485920
15175348
18691976
16407412
10409742
9311917
17192257
7898932
8621729
23934108
11684694
21336309
7624324
12920017
11948406
15466214
11042690
12907640
9032297
27169363
12876277
8933152
8223433
8248196
8131746
12594221
10969079
10567369
17979178
17724343
24746704
19058874
10958680
8090753
21071413
7731720
7873542
1330321
8503013
16093354
19541618
8394352
15466476
25155755
11136732
9069260
94178255
8607979
10327068
10359597
8039496
20212043
|
PIK3R2
|
HRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
31135801
24897931
8665852
17998941
11136978
21779505
8052307
12121613
1716764
26085527
21779497
12094235
|
HRAS
|
PIK3CB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
31135801
24897931
8665852
17998941
11136978
21779505
8052307
12121613
1716764
26085527
21779497
12094235
|
HRAS
|
MAP2K2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
HRAS
|
FGFR1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
Reactome
|
19946327
11429702
11157491
18757403
21666749
21711248
18381441
19103595
21160078
9857065
20179196
|
HRAS
|
FGFR4
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
Reactome
|
19946327
11429702
11157491
18757403
21666749
21711248
18381441
19103595
21160078
9857065
20179196
|
HRAS
|
SOS1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
Reactome
|
19946327
11429702
11157491
18757403
21666749
21711248
18381441
19103595
21160078
9857065
20179196
|
SOS1
|
HRAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
41.0
|
1.0
|
Omnipath
|
12628188
10208427
16713569
10913276
23331499
18454158
15507210
10592173
17673906
17496910
26721396
20133692
19141281
23132018
11560935
9447984
9690470
17084389
|
HRAS
|
PIK3CD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
9069260
9113989
9235916
21779497
11739523
10545207
|
HRAS
|
PIK3CA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
20.0
|
1.0
|
Omnipath
|
9069260
9113989
8052307
24412244
17540175
9931431
11313862
14724584
10592173
9150145
8665852
10783161
|
DVL1
|
AXIN1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11336703
17529994
18077588
17569865
|
AXIN1
|
FZD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11336703
17529994
18077588
17569865
|
AXIN1
|
FZD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11336703
17529994
18077588
17569865
|
AXIN1
|
WNT3A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11336703
17529994
18077588
17569865
|
AXIN1
|
WNT8B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11336703
17529994
18077588
17569865
|
AXIN1
|
WNT8A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11336703
17529994
18077588
17569865
|
AXIN1
|
DVL1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
ACSN
|
10428961
16288291
16940750
19751508
22270359
8666229
|
AXIN1
|
DVL1
|
â—¼ SHARES_COMPLEX
|
|
|
6.0
|
1.0
|
ACSN
|
10428961
16288291
16940750
19751508
22270359
8666229
|
DVL2
|
AXIN1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
10329628
10829020
21245303
23892894
16713569
17529994
|
GSK3B
|
AXIN1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
102.0
|
1.0
|
Omnipath
|
20128690
16944320
11738041
20043192
12511557
11967263
16890161
22613765
14663202
23602568
8524413
24451375
19303846
12554650
8638126
22509369
18593713
16199882
21988832
23331499
19759537
10428961
9482734
22270359
19202075
17570479
16293724
15327768
10581160
17318191
11487578
22773187
26496610
16568235
17318175
19131971
15465828
26912724
25241761
24976009
21242974
22682247
10228155
23579495
12584189
23959799
15020233
10421629
10488109
11278246
9501208
18632848
10481074
10535959
10318824
9554852
17601533
9832503
21502811
9734785
23455922
|
DVL1
|
AXIN1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
18.0
|
1.0
|
Omnipath
|
12556519
11278246
10862053
10330403
10330181
10428961
9482734
10196136
11027605
18339531
|
AXIN1
|
CTNNB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
52.0
|
1.0
|
Omnipath
|
20128690
20531388
16890161
27902311
22509369
18593713
16199882
23331499
9482734
21071413
26496610
19244247
22773187
17318191
10196136
18988627
17208333
19131971
24976009
22682247
10228155
12805222
12000790
10488109
9501208
9601641
18632848
9554852
19166851
23959799
12421363
9734785
11940574
|
DVL1
|
WNT8A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
DVL1
|
FZD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
DVL1
|
FZD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
DVL1
|
WNT8B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
DVL1
|
GSK3B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11336703
17529994
18077588
17569865
|
DVL1
|
WNT3A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
SMAD1
|
DVL1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
12650946
23331499
16621789
|
DVL1
|
CTNNB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
23331499
25241761
10806215
20006983
15735151
|
DVL2
|
WNT11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
11.0
|
1.0
|
Reactome
|
23821037
15936275
10698942
9716412
17130287
9674432
17627283
11358862
11101902
12015986
14636582
|
DVL2
|
WNT8A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
DVL2
|
FZD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
DVL2
|
FZD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
DVL2
|
GSK3B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11336703
17529994
18077588
17569865
|
DVL2
|
WNT3A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
DVL2
|
WNT5A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
11.0
|
1.0
|
Reactome
|
23821037
15936275
10698942
9716412
17130287
9674432
17627283
11358862
11101902
12015986
14636582
|
DVL2
|
WNT8B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
FZD4
|
DVL2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
12958364
27096005
23331499
|
WNT8B
|
FZD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
Reactome
|
11448771
11029007
15459103
12205098
22000856
22653731
11357136
15084453
23256519
23791946
|
DVL3
|
FZD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
GSK3B
|
FZD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11336703
17529994
18077588
17569865
|
WNT11
|
FZD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
Reactome
|
10862746
20006983
17433286
23396967
15143170
15169958
21316585
16495441
20940229
23140633
|
WNT3A
|
FZD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
Reactome
|
11448771
11029007
15459103
12205098
22000856
22653731
11357136
15084453
23256519
23791946
|
WNT8A
|
FZD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
Reactome
|
11448771
11029007
15459103
12205098
22000856
22653731
11357136
15084453
23256519
23791946
|
WNT5A
|
FZD1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
10557084
|
WNT3
|
FZD1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
10557084
|
WNT3A
|
FZD1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
21078818
10557084
11029007
10601008
|
WNT2
|
FZD1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
10557084
|
WNT7B
|
FZD1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
15923619
|
FZD1
|
CTNNB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
29.0
|
1.0
|
Omnipath
|
7641885
15265686
19718039
21602792
210606194
8655584
19705439
19029934
20093472
17430994
21606194
17884187
14747478
22017973
22433869
17143292
20006983
19072724
14704854
16965538
16443747
22007144
16547521
19020754
20940130
21640127
21087212
17127310
21796133
|
WNT2B
|
FZD4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
24032637
21856951
|
WNT7B
|
FZD4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
15923619
24032637
|
WNT5A
|
FZD4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
23331499
10990458
16602827
|
LIFR
|
IL6ST
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
23331499
21071413
24710148
12047380
9716487
8999038
16254248
|
FGF2
|
FGFR1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
ACSN
|
11874475
18232728
18633355
18776941
19508171
19631971
21098712
22652804
23123598
25374926
9242465
|
FGF2
|
FGFR3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
22298955
16597617
866304410574949
9045692
15780951
10574949
8663044
25772309
|
FGF2
|
FGFR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
22.0
|
1.0
|
Omnipath
|
17145710
23331499
18332103
26267536
7687739
16597617
25772309
10830168
11390973
10950949
11121055
17981115
8663044
|
FGF2
|
FGFR4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
7680645
8530375
16597617
1385111
86630448530375
8663044
25772309
|
FGF2
|
FGFR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
41.0
|
1.0
|
Omnipath
|
17145710
15096041
8868466
10490103
16597617
11030354
23597562
1722683
14613973
17086194
14505356
9174056
7730326
25772309
11786412
16829530
10950949
23597563
10574979
26267536
|
FGFR1
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
9.0
|
1.0
|
Reactome
|
17505008
18757403
21666749
11689702
21711248
11739186
21160078
14534538
15448205
|
FGFR1
|
SOS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
11353842
8780727
11447289
7559490
9182757
|
KRAS
|
FGFR1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
Reactome
|
19946327
11429702
11157491
18757403
21666749
21711248
18381441
19103595
21160078
9857065
20179196
|
NRAS
|
FGFR1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
Reactome
|
19946327
11429702
11157491
18757403
21666749
21711248
18381441
19103595
21160078
9857065
20179196
|
EZH2
|
FGFR1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
17.0
|
1.0
|
Omnipath
|
22179855
22312437
21512140
23933322
24737471
23932971
23918806
19053175
19502792
24928441
23424038
24032713
24474760
20634887
18704159
24652950
22072987
|
FGFR1
|
PIK3R2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
17496910
15117958
|
FGFR1
|
CTNNB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
10.0
|
1.0
|
Omnipath
|
17496910
25241761
22558232
11401320
12040186
19568798
14585353
|
IGF1
|
IGF1R
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
ACSN
|
11237532
12181198
17145802
19631971
|
IGF1
|
IGF1R
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
30.0
|
1.0
|
Omnipath
|
21798082
23331499
8452530
21071413
12067807
1852007
21645859
8408032
14604834
19258508
11287679
23675206
19029956
2877871
|
IGF1R
|
CTNNB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
17496910
22558232
12040186
19568798
14585353
|
IGF1R
|
PIK3R3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
17496910
25241761
9415396
9524259
|
PIK3CA
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
25793261
19117013
21041639
24950409
21816939
|
AKT1
|
BMI1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
22505453
23092893
|
AKT1
|
CTNNB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
19.0
|
1.0
|
Omnipath
|
20858269
23331499
20028971
11882383
21303971
17680028
20214616
22094462
17287208
17374729
20398329
21506126
21402455
12040186
19623618
12063252
18218901
|
AKT1
|
EZH2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
12.0
|
1.0
|
Omnipath
|
22391560
24526064
29864144
34230470
16224021
26517694
|
AKT1
|
GSK3B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
99.0
|
1.0
|
Omnipath
|
17428466
15207235
17145710
12052830
10729337
8250835
11756412
11923280
16914735
17623045
16697215
8524413
12054501
20398329
18372248
21506126
20028971
12040186
15808505
16543730
20138985
23331499
21303971
16009706
10385618
20214616
23180781
9373175
16039586
15829723
18988627
16282323
11577096
11035810
18669648
18216173
15169778
12851486
16123141
11882383
23109003
9065430
18691976
22094462
10949026
22710759
11715018
12459251
18636226
17192257
11254732
11278246
20858269
9812896
9582355
15023346
17680028
19369195
7945242
12900420
23552696
18387957
10722653
20832730
18570873
12147701
18505846
17052453
17693255
18218901
|
AKT1
|
AKT2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
11546794
14500673
12176337
11445557
9736715
12149249
11278835
|
AKT1
|
POU5F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
23041284
24497960
|
TCF3
|
ID1
|
â—¼ UP_REGULATES
|
✅
|
+
|
7.0
|
1.0
|
ACSN
|
15169839
16831886
17018611
17299729
17490644
18832382
22564737
|
CTNNB1
|
TCF3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
12107263
15327769
23331499
9488439
11136974
|
FGFR2
|
SOS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
11353842
8780727
11447289
7559490
9182757
|
FGFR3
|
SOS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
11353842
8780727
11447289
7559490
9182757
|
SMAD1
|
ID1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
18381431
15331632
20522807
12296825
|
BMPR1A
|
SMAD1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
11438941
24412244
19620713
9136927
16189514
11792802
|
GSK3B
|
SMAD1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
23331499
18045539
25241761
|
ACVR1
|
SMAD1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
28.0
|
1.0
|
Omnipath
|
19651622
9748228
23331499
9335504
10085121
10652350
9136927
10583507
16189514
11792802
18988627
|
BMPR1B
|
SMAD1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
17.0
|
1.0
|
Omnipath
|
9748228
23331499
9335504
10085121
19620713
9766532
9136927
11792802
15212693
|
FGFR4
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
9.0
|
1.0
|
Reactome
|
17505008
18757403
21666749
11689702
21711248
11739186
21160078
14534538
15448205
|
PIK3R3
|
PIK3CA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
8596638
22402981
9415396
11733063
26496610
25814554
|
NRAS
|
PIK3CA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
8052307
7820549
9150145
8665852
21779497
|
KRAS
|
MAP2K1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
NRAS
|
MAP2K1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
MAP2K1
|
GSK3B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
17081983
21105670
16964243
14617795
30711629
18547980
8382613
17188038
17192257
15020233
|
GSK3B
|
DVL3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11336703
17529994
18077588
17569865
|
GSK3B
|
WNT8B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11336703
17529994
18077588
17569865
|
GSK3B
|
WNT3A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11336703
17529994
18077588
17569865
|
GSK3B
|
WNT8A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11336703
17529994
18077588
17569865
|
GSK3B
|
FZD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11336703
17529994
18077588
17569865
|
AKT3
|
GSK3B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
17.0
|
1.0
|
Omnipath
|
12851486
15023346
21303971
11882383
17680028
9065430
23109003
20214616
22094462
23552696
20398329
21506126
20028971
12040186
18218901
|
AKT2
|
GSK3B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
20.0
|
1.0
|
Omnipath
|
17145710
21303971
11882383
17680028
9065430
20214616
22094462
23552696
12434148
20398329
21506126
26051358
16293724
20028971
12040186
9712142
18218901
|
GSK3B
|
CTNNB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
183.0
|
1.0
|
Omnipath
|
22415718
11967263
27158593
29455668
19303846
19797085
8638126
19293931
23056571
22662165
25352148
16611981
27068260
28337019
10671551
21743491
20688898
16293724
23721711
23552738
18687691
28977889
19622173
12051714
25241761
27683053
28549350
22699938
19565571
23076981
21562161
19575820
20219694
20537194
10330181
21986938
29183346
27773936
11251183
19711366
21035499
19675674
7542250
23151663
24451375
14663202
23804296
8524413
25639486
23770025
18070361
26892600
30143633
9233789
19667122
27507058
19061640
19223551
29387014
23331499
16199882
11533658
18644116
24501426
24913829
11835406
17318191
26014148
25366337
28183999
22640743
26910375
12000790
12114015
18387957
19107203
9832503
16371461
29805709
27462866
20137080
27902311
12040186
19576224
25644994
12615961
19060929
25897075
12851486
15465828
17053159
18952601
10228155
15020233
17444818
20140245
26453498
17052453
16944320
24015932
23602568
24975844
24931005
28948000
20080742
23209942
30271168
28220106
16520547
28430641
11818547
25546293
27672271
11955436
11154277
26373837
16039586
23778311
28697793
20302655
25136145
26905812
22216350
8666229
12957350
23109003
10074433
28529629
20215423
21329734
11254732
9501208
27098453
27281614
30279527
19631635
25482131
18455992
24403311
11274345
|
AKT2
|
CTNNB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
21303971
11882383
17680028
20214616
22094462
17287208
20398329
21506126
20028971
12040186
18218901
|
FZD5
|
CTNNB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
29.0
|
1.0
|
Omnipath
|
7641885
15265686
19718039
21602792
210606194
8655584
19705439
19029934
20093472
17430994
21606194
17884187
14747478
22017973
22433869
17143292
20006983
19072724
14704854
16965538
16443747
22007144
16547521
19020754
20940130
21640127
21087212
17127310
21796133
|
AKT3
|
CTNNB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
21303971
11882383
17680028
20214616
22094462
20398329
21506126
20028971
12040186
18218901
|
APC2
|
CTNNB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
23331499
23840886
10021369
8638126
16510875
10980707
10074433
9823329
|
WNT2
|
CTNNB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
29.0
|
1.0
|
Omnipath
|
7641885
15265686
19718039
21602792
210606194
8655584
19705439
19029934
20093472
17430994
21606194
17884187
14747478
22017973
22433869
17143292
20006983
19072724
14704854
16965538
16443747
22007144
16547521
19020754
20940130
21640127
21087212
17127310
21796133
|
WNT3A
|
CTNNB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
31.0
|
1.0
|
Omnipath
|
21108734
7641885
15265686
19718039
21602792
210606194
8655584
19705439
19029934
20093472
17430994
21606194
17884187
14747478
22017973
22433869
17143292
20006983
24535659
19072724
14704854
16965538
16443747
22007144
16547521
19020754
20940130
21640127
21087212
17127310
21796133
|
CTNNB1
|
TCF7
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
25678599
19358846
16442529
15735151
17143293
9065401
|
MAPK11
|
MAP2K2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
12738796
18039929
11274345
15187187
|
KRAS
|
MAP2K2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
NRAS
|
PIK3CB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
31135801
24897931
8665852
17998941
11136978
21779505
8052307
12121613
1716764
26085527
21779497
12094235
|
KRAS
|
PIK3CB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
31135801
24897931
8665852
17998941
11136978
21779505
8052307
12121613
1716764
26085527
21779497
12094235
|
PIK3R3
|
PIK3CB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
8596638
22402981
11733063
25814554
|
FGFR4
|
SOS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
11353842
8780727
11447289
7559490
9182757
|
NRAS
|
SOS1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
Reactome
|
19946327
11429702
11157491
18757403
21666749
21711248
18381441
19103595
21160078
9857065
20179196
|
KRAS
|
SOS1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
Reactome
|
19946327
11429702
11157491
18757403
21666749
21711248
18381441
19103595
21160078
9857065
20179196
|
SOS1
|
NRAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
23331499
7923364
11560935
9690470
21779497
8493579
|
PIK3R2
|
KRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
31135801
24897931
8665852
17998941
11136978
21779505
8052307
12121613
1716764
26085527
21779497
12094235
|
KRAS
|
FGFR4
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
Reactome
|
19946327
11429702
11157491
18757403
21666749
21711248
18381441
19103595
21160078
9857065
20179196
|
PIK3R2
|
NRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
31135801
24897931
8665852
17998941
11136978
21779505
8052307
12121613
1716764
26085527
21779497
12094235
|
POU5F1
|
NANOG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
20925113
17506876
16153702
20526341
19829295
22855527
17068183
|
POU5F1
|
NANOG
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
18662995
22745796
15860457
20505756
18537119
19522013
18687992
17272500
18338330
17068183
|
POU5F1
|
SOX2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
20505756
12136102
17324942
15988017
17068183
|
INHBB
|
ACVR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
11266516
|
BMPR2
|
ACVR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
23331499
21071413
16446785
7791754
7890683
|
INHBA
|
ACVR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
16189514
11266516
|
ACVR1
|
SMAD5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
9748228
23331499
10652350
10583507
16189514
11792802
10504300
|
BMP4
|
BMPR1B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
7811286
8702914
11282024
8006002
|
BMPR2
|
BMPR1B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
23331499
21071413
16446785
18756288
10712517
7791754
|
BMPR1B
|
SMAD5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
23331499
19620713
9766532
11792802
|
SOX2
|
NANOG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17068183
16153702
21816365
19829295
|
SOX2
|
NANOG
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
22745796
23939864
15860457
18537119
17324942
19522013
|
INHBA
|
ACVR2A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
11117535
8196624
15123686
8622651
9032295
|
INHBB
|
ACVR2A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
11117535
8196624
15123686
8622651
9032295
|
NODAL
|
ACVR2A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
11952836
|
INHBA
|
ACVR2A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
11266516
10746731
1646080
11266510
24018044
9605406
12466190
|
INHBC
|
ACVR2A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
12651901
22710174
|
INHBB
|
ACVR2A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
11266516
1246619011266510
12466190
|
BMP4
|
BMPR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
20.0
|
1.0
|
Omnipath
|
8702914
23331499
21071413
16446785
12045205
8006002
7673243
7644468
|
BMP4
|
BMPR1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
22.0
|
1.0
|
Omnipath
|
8702914
26330344
20860622
21054789
11241215
8006002
16189514
7644468
|
INHBA
|
ACVR2B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
11117535
8196624
15123686
8622651
9032295
|
INHBB
|
ACVR2B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
11117535
8196624
15123686
8622651
9032295
|
LEFTY2
|
ACVR2B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
11952836
|
INHBC
|
ACVR2B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
12651901
22710174
|
INHBB
|
ACVR2B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
9202237
|
INHBA
|
ACVR2B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
23331499
8622651
16446785
9202237
|
NODAL
|
ACVR2B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
23331499
16446785
11952836
|
ACVR2B
|
ACVR1B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
23331499
23180781
8622651
16446785
12364468
18988627
|
NRAS
|
FGFR4
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
Reactome
|
19946327
11429702
11157491
18757403
21666749
21711248
18381441
19103595
21160078
9857065
20179196
|
WNT2
|
FZD8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
23815780
|
WNT3
|
FZD8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
18528331
15454084
|
WNT3A
|
FZD8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
22653731
20093360
22303445
|
WNT5A
|
FZD8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
20093360
21518267
|
BMPR2
|
BMPR1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
18756288
7791754
10712517
|
AKT3
|
TBX3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
25595898
|
PAX6
|
SOX2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
19666824
17825048
11358870
|
WNT3A
|
DVL3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
FZD2
|
DVL3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
DVL3
|
WNT8A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
DVL3
|
WNT8B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
INHBA
|
ACVR1B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
11117535
8196624
15123686
8622651
9032295
|
INHBA
|
ACVR1B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
81675688397373
8167568
8397373
16189514
9605406
7890768
|
INHBB
|
ACVR1B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
11117535
8196624
15123686
8622651
9032295
|
INHBB
|
ACVR1B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
11266516
15196700
12032389
|
INHBB
|
ACVR1C
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
15196700
|
WNT4
|
FZD2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
12325120
|
WNT4
|
FZD6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
10557084
15265686
21541287
|
WNT3A
|
FZD6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
21128903
21665003
|
WNT3A
|
FZD5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
17117926
22753465
24032637
|
WNT3A
|
FZD2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
18215320
19910923
|
WNT7A
|
FZD5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
12857724
23331499
18567805
1285772412857720
|
WNT7A
|
FZD9
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
15705594
|
WNT5A
|
FZD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
16273260
21903638
15578921
17804197
24032637
|
WNT5A
|
FZD2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
2808370
9389482
19008118
24032637
19910923
|
WNT5A
|
FZD6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
16273260
21665003
|
WNT5A
|
FZD5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
23331499
11029007
9054360
|
WNT2
|
FZD5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
18302287
24032637
|
WNT2
|
FZD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
19038973
24032637
|
WNT2
|
FZD9
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
23331499
12138115
19038973
|
NODAL
|
ACVR1B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
19874624
11952836
|
FZD2
|
WNT8A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
Reactome
|
11448771
11029007
15459103
12205098
22000856
22653731
11357136
15084453
23256519
23791946
|
FZD2
|
WNT8B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
Reactome
|
11448771
11029007
15459103
12205098
22000856
22653731
11357136
15084453
23256519
23791946
|
ACVR1C
|
NODAL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
15485907
21229555
21356369
15150278
15531507
|
NODAL
|
ACVR1C
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
12606401
15531507
|