Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
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Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
FGFR3 CDK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CKS1B CDK2 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
GLI1 CDK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20647328
FOXO1 BMP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15688035 16100571
FOXO1 ABCB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18390843
SRC MAPK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16580177 9924018
FOS MAPK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7588633 12134156
AR MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14619959 20610535
MAPK1 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15263086 15466214
MLST8 RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12087098 9465032
AR PMAIP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17721441
CREB1 POLK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17099721
TNFRSF1A PTPN11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11786908 6731384
FRS2 PTPN11 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
IFNB1 PTPN11 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 10022928 18508557
PPP2CB PTPN11 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 17993263 15031289
PPP2R1A PTPN11 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 17993263 15031289
PTPN11 SRC â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 8288622 20308328
PTPN11 JAK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 8766559
RUVBL1 TNFRSF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
RUVBL1 TBK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
SFRP2 FZD5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 28840375
TUBB6 TNFRSF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
ATP5F1A TNFRSF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
FUS SEM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SEM1 FUS â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ELOC CUL2 â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 5219492 17183367
CUL2 ELOC â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 19327355 7014028
KCNA4 DLG4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5215250 11937501
HEY2 ARNT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10692439
SRC SHC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10964917 8755247
SHC1 INSR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6805769 9593725
RAC2 VAV1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 18589439 8990121
SRC VAV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1531699 1311423
VAV1 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1531699 1311423
SMAD3 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8308197 22045334
SMAD3 PPP2R1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
AR SMAD3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20739403 20610535
SMAD3 GLI2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19797115
SMAD3 BAMBI â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15240101
SMAD3 EPO â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14741200
CREB1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16862174
EIF4E SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12150994 23331499
SMAD3 PAX8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14623893
IFNG CAMK2B â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
IFNG CAMK2G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
TCF7 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19648923 26714756
TGFB1 BAMBI â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10519551 19758997
TGFB1 VTN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11796824 16189514
FGFR3 RELA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RELA BMP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17350185
RELA AGER â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18622638 19616578
CSNK2A1 RELA â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5212888 10938077
FOS RELA â—¼   PROXIMITY 2.0 0.8 intact 18172215 0705181105
RELA FOS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16189514 10488148
AR IL15 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22653339 20610535
NFKB1 IL15 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21343618 10906187
FGFR3 DVL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
GLI1 FRZB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16328026 17035233
CSNK1A1L GLI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16481469 23331499
UBC SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6504434 17936276
RRAS SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
SRC PTK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6672010 16291744
RALA SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10675331 12110590
SRC FOS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17160021 22105363
VTN SERPINE1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216470 12808446
AR SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1384159 20610535
ESR2 SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15217907
GLI2 BMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19103752 16880529
GLI2 BMP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18710724 20934421
CSNK1A1L GLI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16481469 18698484
FGFR3 IGFBP4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FOS BMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19009553 18495116
FOS NFKB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20188076
NFKB1 CSNK2A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19027835
NFKB1 BMP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17350185
NFKB1 AGER â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18622638 19616578
CREB1 TCF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20864035
HBEGF FGFR3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FGFR3 MAPK11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CREB1 ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23466342 21054339
CREB1 IL5RA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9742933
MAPK11 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11532940 11335727
AR INSR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20610535 20417685
UBC TBK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18636086 6804508
UBC PCGF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7998286 20601937
PPP2CB RALA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17540176
AR ESR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11371645 20610535
ATP5F1A TBK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
SOX2 ISL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20739473
TBX3 BMP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22387209 17173667
WNT5B FZD8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 26849959 20093360
GLI3 PTCH2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14691458
WNT5B FZD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16273260 15578921
IHH PTCH1 â—¼   PHYSICAL_INTERACTION ✅ - 0.81 0.81 Signor 9811851
CDK2 UCHL1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21319273 23543736
INSR SHC1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 9121430 10482988 8702728 7559507 12237775 9446569 11075717 9710204 10803466 10896916 9741627 10921922 9593725 10816433 9083103 15629149 7499194 10764799
HDAC2 FUS â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30737378 26949739
ESR2 PSMD1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 29509190 21182203 25604459
DLG4 FZD7 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 12067714
NDUFA13 UQCRC1 â—¼   PHYSICAL_INTERACTION 829.0 0.83 STRING 36370105
ESR2 UBE3A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 33456993 17962381 25408199
BRAF MAPK1 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
HEY2 HAND1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10924525
AR SRC â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
ADRM1 UBC â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 31064842 20059542
DROSHA FUS â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
CSNK1D MAPT â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
PLD1 RALA â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9688545 9207251
MAPK1 SHC1 â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
INSR PTPN11 â—¼   PHYSICAL_INTERACTION 866.0 0.86 STRING 36370105
RUVBL1 TTI1 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
PTK2 PTPN11 â—¼   PHYSICAL_INTERACTION 869.0 0.87 STRING 36370105
ATG14 NRBF2 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
NRBF2 PIK3R4 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
PBRM1 SMARCE1 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
UCHL1 UBC â—¼   CLEAVAGE ✅ + 0.87 0.87 Signor 9521656
SHC1 SRC â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
FOS SMAD3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 21829441 9732876
SRC ESR2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 12095943 12630920 15604093 11013076 11032808
HDAC2 RELA â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
CSNK2A1 HDAC2 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
SHC1 CSF3R â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 9824671 14557262 17001306
INSR SHC1 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
FRS2 PTPN11 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
FOXO1 SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11919188 19563779 17384280
NFKB1 IL1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17513725 17612514
FOS IL1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8688489
BRAF MAPK1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16508002 14654779 19933846
MAPK1 CSNK2A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19941816
MAPK1 KLC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21385839
MAPK1 FRS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12419216 12974390
PSMD1 UBC â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
HLA-C PTPN11 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 11513144 21339333 9605119
FRS2 PTPN11 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 11447289 17673906 25772309
CSNK2A1 TTI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 23263282
RALA PLD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10611224 9207251
PPP2CB AXIN2 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 intact 1203359 10698523 8285077
VAV1 SHC1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9209406 8677749 7539782
EPO VAV1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9209406 8677749 7539782
INSR VAV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11094073 7535775
SMAD3 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15086314 23161884 16619037
HLA-C IFNG â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 11513144 21339333 9605119
RELA AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16713569 8798655
DVL2 CCDC88C â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 14750955 21031079 22643886
RYK DVL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15454084 23331499
DKK1 WNT9B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17804805 11448771 22807036
GLI1 SFRP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16328026 17035233 19930158
SRC PPP2R1A â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15637081 15004239 15564375
SRC PPP2CB â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15637081 15004239 15564375
NFKB1 SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12675842 11757833 15631825
FOS SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8917435 11223948 12390531
FGFR3 FRS2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10629055 9660748 18373495
FGFR3 FRS2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 12767520 17496910 17673906
ESR2 FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20155458 10037443
NFKB1 ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18234965 12527911 19763573
MAPK11 TCF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15719023
CREB1 RARB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath
PPP2R1A PPP2CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15936019 16039140
PPP2CB RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 2826472 11124802 10200280
DCTN4 DCTN2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 22863883 33961781 27173435 26186194 28718761 26344197
KLC1 KIF5A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 3130248 1607388 3134048
NRBF2 PIK3R4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 28059666 32296183 24785657
CAMK2B PRKAA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15980064
ESR2 GPX3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20034404
CSNK1A1L GLI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16481469 23331499
WNT9B FZD5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 30978219 25892522 28733458
CYC1 NDUFA13 â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
UBC USP8 â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
DLG4 KCNA4 â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
PPP2CB PPP2R2B â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
NDUFV2 UQCRC1 â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
TBK1 TANK â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 5220020 17568778
PPP2R1A PPP2CB â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 5217765 15936019
ARID1B SMARCE1 â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
PSMA4 UBC â—¼   PHYSICAL_INTERACTION 926.0 0.92 STRING 36370105
PTK2 SRC â—¼   PHYSICAL_INTERACTION 931.0 0.93 STRING 36370105
CKS1B CDK2 â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 8601310 5220942
ATP6V1C2 ATP6V1G1 â—¼   PHYSICAL_INTERACTION 940.0 0.94 STRING 36370105
KIF5A KLC1 â—¼   PHYSICAL_INTERACTION 942.0 0.94 STRING 36370105
PPP2R1A PPP2R2B â—¼   PHYSICAL_INTERACTION 944.0 0.94 STRING 36370105
TANK TBK1 â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
ADRM1 PSMA4 â—¼   PHYSICAL_INTERACTION 967.0 0.96 STRING 36370105
SERPINE1 VTN â—¼   PHYSICAL_INTERACTION 968.0 0.96 STRING 36370105
ADRM1 PSMD1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 32857986 19781552 26466095 31064842 16990800 22863883 33961781 26186194 32160516 16501559 28442575 26344197 28598414
TBK1 TANK â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 21931555 16189514 31114588 21988832 30420664 21903422 14743216 10581243 29395067 30561431 23286385 27035970 25409927 17823124 32707033 17568778 24488098 23007157 33961781 18307994 29251827
CUL2 ELOC â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 19327355 17183367 24076655 19339690 15966899 23563313 9447969 15601820 10449727 26735018 25661653 11384984 31444342 24981860 21145461 9122164 30166453 29991678
SRC SHC1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 10482988 16189514 7499252 9096689 9710204 18840094 8939605 9388490 26551075
ACTR1B DCTN4 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
ACTR1B DCTN2 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
ADRM1 UBC â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
MAPT PPP2CB â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
KLC1 KIF5A â—¼   PROTEIN_INTERACTION 0.98 0.98 HIPPIE 28514442 10491391 33961781 9624122 22939629 26344197
CYC1 NDUFV2 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
UBC UCHL1 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
CDK2 CKS1B â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
CYC1 UQCRC1 â—¼   PHYSICAL_INTERACTION 989.0 0.99 STRING 36370105
UBA1 UBC â—¼   PHYSICAL_INTERACTION 989.0 0.99 STRING 36370105
DLG4 KCNA4 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 11744724 8601796 12435606 9581762 7477295 11937501 11997254 11723117 8938729
DCTN2 DCTN4 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
ADRM1 PSMD1 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
GNB3 GNG5 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB3 GNG7 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
NDUFA13 NDUFV2 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
PSMA4 PSMD1 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
PPP2CB PPP2R1A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CDK2 SMAD3 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 10197981 11283614 12193595 14536078 15147722 15241418 15279786 16156666 17055429 17303408 17660363 18590585 18636226 20027199 20713526 2191300 28536364 7575488
MAPK1 CDK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10962581 12359725
CDK2 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 34.0 1.0 Omnipath 10197981 15241418 19218245 25241761 15520018 20068231 17099224 16156666 16189514 19413330 14512875 12193595 15212693 19114991
CDK2 FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 21106439 19652536 7575488 18590585 17522590 17303408 27035875 19473886 24948874 15677884 15279786 23029264 19124971 17660363 17038621 20148668
CKS1B FOXO1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11516665 12820959 15071497 15147722 15340381 15459660 15668399 15688063 18931676 19622404 19686080
FOXO1 ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18301748 20713551 23763570 18390843
AR FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 18391971 17202144 16713569 12482965
CSNK1D FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 14710188 16511445 21233202 7641885 11980723 15121840
SMAD3 FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18391971 15084259
IL15 IL1A â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 10426994 10952726 11907067 14607946 15536084 16713974 17398124 17459805 19913445 20007590 21307131 25582338 7523571
RELA IL1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 27371733 21131967 23195252 17612514 27076634 21106671
FGFR3 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MAPK1 SMAD3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 10197981 16156666 27153775 29577978
MAPK1 FRS2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
VAV1 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 23331499 8900182 9013873
PPP2CB MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 18039929 16680151 16456541 10995457 18042541 7780739 18588945 2154696
SHC1 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10996427 23584453
MAPK1 MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 67.0 1.0 Omnipath 9614189 9832145 12387894 12766916 12765608 12414518 19413330 1330687 24116116 19415658 15302935 33961674 9716264 34493616 31178717 28066266 15324364 31065832 25573097 12801934 29298849 16165272 15883264 16115884 8166686 33952699 9565682 11181841 34536819 10737616 7566346 18315566 9771888 29760653 34480088 24301651 15542598 18055457 12226093 7488031 9199504 18510355 21731772
MAPK1 RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 43.0 1.0 Omnipath 12054624 15547943 20080742 14967450 12040186 15173823 12697810 11940578 7545671 16227978 21035469 12738796 16039586 9722592 17255949 15774499 15187187 19541618 19091303 19565474 17052211 19085255 11279232 9271440 18039929 18775330 11705993 10601235 12792650 11431469
MAPK1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 53.0 1.0 Omnipath 19218245 18032789 18729074 16156666 19914161 23331499 19914168 24080014 8226933 14512875 15520018 20736297 26497676 12193595 26297431 18988627 8388392 10197981 15241418 18775330 9604935 9380693
MAPK1 BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 14654779 21478863 19541618 16508002 19710016 19933846 15664191 29335436 8621729
MAPK1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 18511414 9725910 10318905
MAPK1 TNFRSF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 10702263 11606045
MAPK1 FOS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 49.0 1.0 Omnipath 12134156 20506250 15547943 8248197 7816602 15084594 12697810 8226933 20068231 18452278 12738796 16393692 17255949 17439715 15187187 19541618 23109003 19565474 17722974 17052211 7588633 8545107 16055710 8388392 18039929 12972619 18775330 21098038 9604935 11274345
MAPK1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15073167 16888388 16691505
MAPK1 TCF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 14592976 12810726
CSNK1D MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17570479 14761950
MLST8 PRR5 â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 12408816 12906785 16469695 17680028 18492954 18566586 19022819 19143635 19568798 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MLST8 PRR5 â—¼   SHARES_COMPLEX 18.0 1.0 ACSN 12408816 12906785 16469695 17680028 18492954 18566586 19022819 19143635 19568798 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MLST8 MMP9 â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 12150925 12408816 12906785 15755954 16469695 17680028 18492954 19022819 19568798 19864431 19930715 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26597054 27328425 27510662 27572739 28216025
MLST8 IFNG â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 12150925 12408816 12906785 15755954 16469695 17604271 17680028 18372248 18492954 19022819 19143636 19446321 19568798 19706736 19864431 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 28216025
AR PMAIP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20610535 17721441 16479009
HLA-G PTPN11 â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10925299 11438547 11489965 11513144 11875494 11994457 12055234 12811837 15081523 15778339 16287995 16713974 17100877 20435894 23414611 23508573 24378531 9625766 9751747
PTPN11 IFNG â—¼   DOWN_REGULATES ✅ - 34.0 1.0 ACSN 10358138 11447289 11449354 11572860 12138178 12176909 1238444 12393695 12421919 12707331 12773515 12917349 15169881 15240681 15699106 15713798 16204085 19833085 20363967 20435894 21469115 22483603 22513334 22683124 22952938 22955274 25355530 26667266 26755705 27474009 8976179 8986721 9751747 9765283
FRS2 PTPN11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 23331499 10650943 9632781 11360177 11447289 29997244 12974390 16189514 25159185
INSR PTPN11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 8135823 9832615 7493946 9593725
PTPN11 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 23335101 7589239 10082579 21726809 14572662 15561106 8986614 16189514 10655584 19698715 16920701 15598735
PTPN11 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 18950707 23109003 16371368 17722974 22315502 16107703 9660791 8080844 9632795 15790353
PTPN11 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 18757826 18482983 10698938 17974954 14687660 24632723 20308328
TANK TBK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 16127453 17568778 27035970 25409927 23286385 18307994 24488098 21419663 21988832 21903422 15210742 14743216 16189514 19820708 21931555 10581243 23007157 17823124 17468758 17327220
AR TNFRSF1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20610535
DVL2 FZD7 â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 23821037 15936275 10698942 9716412 17130287 9674432 17627283 11358862 11101902 12015986 14636582
FZD7 NOX1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 16636067 18347018 11779461 12716910 8947551 16329988 16762923
TCF3 AXIN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 19751508 7542250 8666229 11955436 11967263 22270359 16940750 12051714
FGFR3 SHC1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9045692 9480847 18840094 7559490
SHC1 HBEGF â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 18721752 21376233 8617750 8665853
PTK2 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11980671 10592173 16713569 10725339 10749687 9566877
TGFB1 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 12767520 22710166 19010789 16474430 19920116 22943793 17934056 20519943 12809600 21900405 11133108 14557817 15548370 17673906
SRC SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 55.0 1.0 Omnipath 19901323 9388490 8939605 9096689 10971656 16497976 15592455 9121430 10891441 17389395 11687594 10329689 10482988 20068231 17570479 16189514 9685404 23109003 7516469 9927207 18840094 15688026 15212693 1409579 14963047 9710204 26551075 17016520 11075717
INSR SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 93.0 1.0 Omnipath 9083103 17145710 19901323 10803466 20230923 16497976 9121430 15592455 9446569 17389395 18578522 7559507 7537849 10482988 10764799 10921922 18452278 20068231 10592173 7499194 18669648 15629149 12522270 9685404 10896916 9927207 9593725 12237775 8702728 8610109 19651622 15212693 9741627 9710204 19664994 7685165 8626723 17016520 10816433 11075717
SRC VAV1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17686471 8986718 11007481 10395673 9099726
TGFB1 SMAD3 â—¼   PHYSICAL_INTERACTION 30.0 1.0 ACSN 10678166 11013220 11133108 11278410 11792802 12154066 12717440 12724770 14557817 15265520 15548370 16474430 17934056 19010789 19050695 19109155 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22703233 22710166 24132110 24336330 7594497 9311995 9865696
TGFB1 SMAD3 â—¼   SHARES_COMPLEX 30.0 1.0 ACSN 10678166 11013220 11133108 11278410 11792802 12154066 12717440 12724770 14557817 15265520 15548370 16474430 17934056 19010789 19050695 19109155 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22703233 22710166 24132110 24336330 7594497 9311995 9865696
TGFB1 SMAD3 â—¼   ENZYMATIC_REACTION ✅ 30.0 1.0 ACSN 10678166 11013220 11133108 11278410 11792802 12154066 12717440 12724770 14557817 15265520 15548370 16474430 17934056 19010789 19050695 19109155 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22703233 22710166 24132110 24336330 7594497 9311995 9865696
SMAD3 GLI1 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 8515656 9389648
SMAD3 GLI2 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 8515656 9389648
IL15 SMAD3 â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 10426994 10952726 11907067 14607946 15536084 16713974 17398124 17459805 19913445 20007590 21307131 25582338 7523571
SMAD3 IFNG â—¼   DOWN_REGULATES ✅ - 25.0 1.0 ACSN 10925299 11074002 11279127 11399519 11792802 11875494 12193690 12702545 12809600 15265520 15644117 16127449 16179589 16713975 17260466 17689680 18768831 21042762 21614932 22331441 23390297 6357187 8515656 8871614 9389648
SMAD3 SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 19643931 15840021 19563779 12551947 24330518 9792626 19132220 19887897 11590145 9765209 19586629 18333754 16169848 15561701 10092624 10557285 20093492 11387330 9606191 17761371 23063463 15198928 9380693
SMAD3 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 26553048 27974707 10708950 19214138
TGFB1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21557273 24899689 24075003 24485922 28756206 32196115
SMAD3 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 23331499 11248024 11280774 12226080 16713569 11707452
HLA-G IFNG â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10925299 11438547 11489965 11513144 11875494 11994457 12055234 12811837 15081523 15778339 16287995 16713974 17100877 20435894 23414611 23508573 24378531 9625766 9751747
IFNG RELA â—¼   ENZYMATIC_REACTION ✅ 48.0 1.0 ACSN 10485906 10679398 11489965 11579131 11777960 11870632 11964313 12133954 12413632 12759422 12818165 14607900 14668329 15079071 15536066 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17145890 17404308 17550372 17559085 1825141 18272812 19171876 19833085 20038811 20138012 20819927 21149606 21224476 21411734 23430059 24658051 26755705 2965306 6425450 8383323 8580069 8641346 9743347 9834059 9864217
NFKB1 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 12759422 21642544 21243522 9374532 10227974 16481345 17556653 19732956 21224476 14662860 12757742 18690006 17407192
RELA IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 17035338 12759422 12105194 21243522 9374532 10227974 20643337 19929594 19732956 21224476 23195252 23667107 12842891 14662860 12757742 18690006 17407192 10075983
CREB1 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 20979795 11907114 20006311 12928400 16713974 22413812 7759501 12626576 9834094 15879136 20685939 18641343 9503023
FOS IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19285436 16713974 7759501 8756632 12842891 12432566
FOS MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 16554298 11774399 21238464 18809380 23508111 21474819 15319566 10935492 21940623 24173318 16882662 21047770 9136992 23955082 23176293 12032150
NFKB1 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 18298869 12105194 11376631 14600595 17673602 17922642 15605368 14755547 20332461 18357389 17186550 11060311 18566231 9679762 16687076 17121934 18843978 21963718 18056465 20103608 17174275 15536164 19303700 17158602 7860222 19539355 9500201 19783786 18567920 15175338 17498959 10359016 18801463 19454280 19662350 12193473 16014933
RELA MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 48.0 1.0 Omnipath 18298869 12105194 11376631 14600595 17673602 23423566 17922642 15605368 14755547 20332461 18357389 21502320 17186550 11060311 18566231 9679762 16554298 16687076 17121934 15086314 18843978 21963718 18056465 20103608 21238464 17174275 15536164 18028425 17158602 17590163 19303700 7860222 19539355 9500201 22587999 19783786 18567920 15175338 17498959 19616091 10359016 18801463 19454280 24755270 19662350 12193473 16014933
MMP9 TGFB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10652271 21900405 25241761
PDCD4 EIF4E â—¼   DOWN_REGULATES ✅ - 7.0 1.0 ACSN 12482958 17053147 17968323 17991735 18372920 19356152 23070007
FOS TGFB1 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 15067049 15749884 16243976 16327802 16393692 16394015 16413922 16713974 17404308 17485448 19667062 20547845 21372296 21385848 22634314 23390297 23430059 9064320
TGFB1 SRC â—¼   ENZYMATIC_REACTION ✅ 56.0 1.0 ACSN 10671552 11133108 11348595 11476890 11955436 11967263 12051714 12426320 14557817 15001769 15279786 15548370 16039586 16099633 16371504 16474430 16919435 17143292 17303408 17496910 17517963 17660363 17928543 17934056 17936032 18037882 18590585 19010789 19029934 19109155 19171760 19619488 19734908 19920116 20519943 20644162 20705860 21278795 21666923 21900405 22007144 22174153 22203675 22370635 22674073 22703233 23343194 24023259 25572304 25730849 26552706 27216177 7542250 7575488 7594497 8666229
RELA TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19385047 23195252 28148567 14600158 16365456 21255844 15051419
CSNK2A1 HDAC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 19007248 16565220 20166139 17081983 20230923 25609639 19413330 19415658 20388487 20068231 18452278 18669648 18691976 17287340 12176973 19651622 12082111 19691289 24526703 18510355 18212344
NDUFV2 NDUFA13 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094
NDUFV2 NDUFA13 â—¼   SHARES_COMPLEX 10.0 1.0 ACSN 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094
ATG14 PIK3R4 â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 17106237 17446862 18612260 22093031 22166994 22421439 22885520 23030059 23301705 23377657 23725295 24070470 27754749 28645028
ATG14 PIK3R4 â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 17106237 17446862 18612260 22093031 22166994 22421439 22885520 23030059 23301705 23377657 23725295 24070470 27754749 28645028
CREB1 RELA â—¼   PHYSICAL_INTERACTION 21.0 1.0 ACSN 11579131 12417340 15079071 15187187 15279786 15337521 15536066 16007092 16713974 17303408 17550372 17565603 17660363 18590585 19171876 19879327 20144767 23430059 7575488 8383323 9743347
NFKB1 RELA â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
CREB1 RELA â—¼   PROTEIN_INTERACTION 21.0 1.0 ACSN 11579131 12417340 15079071 15187187 15279786 15337521 15536066 16007092 16713974 17303408 17550372 17565603 17660363 18590585 19171876 19879327 20144767 23430059 7575488 8383323 9743347
CREB1 RELA â—¼   DOWN_REGULATES ✅ - 21.0 1.0 ACSN 11579131 12417340 15079071 15187187 15279786 15337521 15536066 16007092 16713974 17303408 17550372 17565603 17660363 18590585 19171876 19879327 20144767 23430059 7575488 8383323 9743347
RELA AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 24466341 16619263 14576180 15517885 14715080
RELA SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12675842 10839991 15631825 11757833
RELA NFKB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 16778171 20427719 23362108 16513645 1740105 20596645 16513841 19469019 8454856 21420936 16135789 9417120
RELA ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18234965 21054339 19763573 12527911 22927901 10026303
RELA IFNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 23932714 15955070 22547704 19570999 10074115 21209118 17079305 7799921 17496231 15699120 12077266 8035474 17785777 12005436 24185615 10848607 16125763 9446577 20855868 24656046 23857586
NFKB1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 88.0 1.0 Omnipath 17145710 16209943 25609649 8428580 12947093 16970925 17072323 2050119 15657065 21270162 11976329 16793322 21544861 22261743 8657102 9824778 11880271 9450761 17962807 21988832 25355951 9722548 18215660 14743216 15799966 10799898 16105840 15218526 8798655 14690596 22139845 22808155 11571291 17072327 16740634 10498867 8255759 8246997 15214841 16846590 15371334 16285893 17072322 17855547 18321863 16493424 7479976 15145317 17561400 20110362 9426183 23687337 12414801 11970949 20154269 20237821 24175631 24634218 34100597 14645533 17982102 21763497 16204234 9437432 20547752 15818410 7628694
CSNK2A1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 34049972 15016307 10938077 27630163
TBK1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 12842894 17562815 15128824 15485852 10521409 15489227 15849198 14560022 19958770 12767944
IL15 IL12RB2 â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 10426994 10952726 11907067 14607946 15536084 16713974 17398124 17459805 19913445 20007590 21307131 25582338 7523571
DVL2 NOX1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 16636067 18347018 11779461 12716910 8947551 16329988 16762923
DVL2 FZD2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL2 FZD1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL2 CSNK2A1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7744250 21285348 10698942 9192851 9214626
FZD4 DVL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12958364 27096005 23331499
CSNK1D DVL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21316585 22609948 29426949 31579410
GLI1 PTCH1 â—¼   ENZYMATIC_REACTION ✅ 27.0 1.0 ACSN 11001584 11960000 12138125 14555646 15087129 15520176 16054035 16158046 16328026 16396903 16406505 16571352 16880536 17000779 17035233 17638910 18754008 18813803 19081070 19190345 19219074 19736394 20107231 21059263 21442356 22354771 23031257
GLI1 SFRP1 â—¼   ENZYMATIC_REACTION ✅ 27.0 1.0 ACSN 11001584 11960000 12138125 14555646 15087129 15520176 16054035 16158046 16328026 16396903 16406505 16571352 16880536 17000779 17035233 17638910 18754008 18813803 19081070 19190345 19219074 19736394 20107231 21059263 21442356 22354771 23031257
GLI3 GLI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12435627 14723851 10075717 16571352 19667090
GLI2 GLI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16571352 15175043 12165851 9636069
GLI1 PTCH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19860666 21076395 11719506 16571352 15087129
PRKAA1 GLI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 26843621 26190112
GLI2 GLI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 18813803 16880536 19190345 18698484 15087129 17845852 19049965 11001584 20107231 20712011 15520176 16406505 17000779 16413481 16571352 16396903 9609833 18497536 14555646 9216996 20581804 11493558 15140221 16054035 20143239
RPS6KB1 GLI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 26512695 29163356 28735864 25476449 22439934 24661902 23880852 25134527
GLI1 PTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 16158046 18813803 19219074 16880536 21059263 11960000 19190345 15087129 21442356 16328026 19736394 11001584 12138125 20107231 15520176 16406505 17000779 16571352 16396903 14555646 17035233 16054035
GLI1 PTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 16158046 18813803 19219074 16880536 21059263 11960000 19190345 15087129 21442356 16328026 19736394 11001584 12138125 20107231 15520176 16406505 17000779 16571352 16396903 14555646 17035233 16054035
SRC PTK2 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 11476890 12531888 16919435 17496910 17517963 20027185 25572304 26552706 27216177 8892616
AR SRC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19305643 10454563 18687691 17108144 17079466
ESR2 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11013076 12095943 12630920 11032808
SRC PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21780115 15032589 11526404 23109003 22880054 10488096
SRC AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 28144231 15062576 20570899 25133482 21318111 11032808 25950519 21512132 17525795 12933816 20383201 24728074 24948875 24868554 25547388 19117998 21956655 17045208 15027889 24859991 15466214 26829214 21886458
SRC PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 216.0 1.0 Omnipath 27351421 23242524 16254240 12370821 21940449 26142360 17525734 10593973 14604860 17389395 19171305 22402981 19339212 22353809 9748249 8941336 17570479 12464388 25226367 15611085 15817476 25241761 26393679 27978555 26833789 11927607 17828307 25913180 26866924 15247219 10085298 12387730 19055942 9507031 21454698 10973994 32814053 21057587 27931517 27438371 18793427 19695571 15735019 18560762 10592173 25319025 24389213 21852560 26689988 14984767 7505391 19568240 20103658 20822514 25868388 23275294 28423510 23764511 19625610 15561106 17192257 19138410 19369195 17088251 12753909 28701735 29190494 17016520 15598735 18814847 11821402 11418135 15728464 16291744 25067788 11602246 16713569 22287273 9032297 7997267 12960434 11369622 20616959 26079101 19534553 10931187 22710722 20068231 25866790 21347260 9822703 28202937 16153436 11980671 21855630 19826415 18464795 7529876 20621036 9330873 21473875 9425168 28956212 12615911 15951569 25814554 12876384 17438336 15212693 16966330 20705914 20847951 23729178 20407018 12558988 25127991 25918719 12590707 16360410 8054685 18814027 11696015 22800863 17117420 12495636 11278488 9864370 21776383 18083107 22814579 22194915 20515733 11119718 9148935 10428489 15743500 20655298 23065768 28213315 26923073 24015220 17289681 12110680 22006118 24164353 23109003 18935208 10753828 18233957 8816475 25118939 19664994 25530216 16760434 9330875 21266176 21034468
SRC RRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 17474147 15212693 10570155 11682467
SRC DLG4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 24981431 16990796 14529711 18721130
CREB1 SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18471910 20136501 17721610
VTN SERPINE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 11113116 12808446 11796824 8830783 16713569 9065424
GLI2 PTCH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 14691458 9636069 16571352 15087129 19574535
GLI3 GLI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 21234400 20562908 9216996 19032343 12435627 16406505 19114989 16880536 16054035 11001584 17000779 16169709 16413481 15087129 16396903 19809516 20107231
CSNK1D GLI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 21233202 7641885 16611981 21536646 19797085 18455992 16371461
GLI2 PTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 18813803 16880536 19190345 18698484 15087129 17845852 19049965 11001584 20107231 20712011 15520176 16406505 17000779 16413481 16571352 16396903 9609833 18497536 14555646 9216996 11493558 15140221 16054035 20143239
GLI2 PTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 18813803 16880536 19190345 18698484 15087129 17845852 19049965 11001584 20107231 20712011 15520176 16406505 17000779 16413481 16571352 16396903 9609833 18497536 14555646 9216996 11493558 15140221 16054035 20143239
VTN ITGB8 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 7525578 7559467 17968485 9251239 7685013 9443892
CSNK2A1 VTN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9733784 31291285
VTN ITGB8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11156415
IHH PTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23331499 29274272 9811851
IHH PTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 23331499 115627869811851 19399989 20083481 29274272 11562786 9811851
NFKB1 IFNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 15955070 17079305 7799921 17496231 15699120 10074115 20855868 24656046 10848607 12077266 8035474 17785777 20048166 21209118 16125763 12005436 22427889 21343618
NFKB1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 14576180 15517885 20159994 12165860 16619263
RPS6KB1 PDCD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 33.0 1.0 Omnipath 17053147 19339977 28692058 16286006 19901084 27028868 20647036 11108711 23415227 12482958 18296647 18423201 23466868 21233202 25573956 19720745 12713446 16357133 21378410 28899909 15905173 20661426 20832730 24405715 17052453
CREB1 TNFSF11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12364326 23439434 19880655 16914731 17053039 15731115
CAMK2G CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 11175347 12356771 15733869 8887554 9528766 11018520 11698596 11160957 11969286 12235136 7958915 9829964 9687510 11909979 8688081
CAMK2B CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 11175347 12356771 15733869 8887554 9528766 11018520 11698596 11160957 11969286 12235136 7958915 9829964 9687510 11909979 8688081
INSR PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 9507031 17389395 19664994 20068231 17570479 17016520 7529876 16153436
AR UBC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17409431 20610535 17721441
UCHL1 UBC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23801757 22284438 20622874 16169070 20439756 9521656 2532544 27066941
CSNK2A1 ARNT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 16129408 18669648
CSNK1D GLI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21233202 7641885 16611981 21536646 19797085 18455992 16371461
ARNT EPO â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 8089148 10207038 20631191 11782478 8663540 8408001
GLI3 PTCH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 19860666 17419683 28533268 24276242 10077605 16571352 15087129
GLI3 PTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 21234400 20562908 9216996 19032343 12435627 16406505 19114989 16880536 16054035 11001584 17000779 16169709 16413481 15087129 16396903 19809516 20107231
RYK FZD8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15454084 17035295
GLI3 PTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 21234400 20562908 9216996 19032343 12435627 16406505 19114989 16880536 16054035 11001584 17000779 16169709 16413481 15087129 16396903 19809516 20107231
SFRP1 FZD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 6172602
SFRP1 FZD6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 10347172