Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
HSP90AB1 AIP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19375531 7021854
CCT8 CCT6A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
CEBPB HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9880553 10440232
CEBPB HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18266962
COA7 TRIM63 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 31391242 233395
E2F1 PDK4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18667418 21625432
ESRRG ESRRA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17157980 15821111
PPARG ESRRA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20519122 15821111
NR0B2 ESRRG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21459093 8150833
NR0B2 ESRRG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11705994 19721712
ESRRG NR0B2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11705994 14627819
NR3C1 FOXO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19059383 20079455
FOXO1 SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21149440 23430617
FOXO1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16670091 19289458
FOXO1 TRIM63 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21798082 18612045
FOXO1 TRIM63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18612045
NR3C1 FOXO3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22848740
FOXO3 SIRT1 â—¼   DEACETYLATION ✅ 2.0 0.8 Reactome 14976264 23665396
STAT5A LONP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15528381
NR0B2 PDK4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22698918 21081708
NR0B2 PPARGC1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18385139 16213225
NR0B2 SIRT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20375098
NR1H4 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21279417 15973435
NR3C1 TRIM63 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18615595 18612045
SP1 PDHA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8476854
THRAP3 PDK4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
STAT5A PDK4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22698918 17360981
SP1 TRIM63 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22469463 10954564
CCT2 CCT4 â—¼   CORRELATES + 0.8 0.8 CCLE 31978347
POLR2B RPAP1 â—¼   PHYSICAL_INTERACTION 807.0 0.8 STRING 36370105
PDK4 ODPA â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 11486000 19081061 27505672 12676647 11485553
CNOT10 CNOT2 â—¼   PHYSICAL_INTERACTION 810.0 0.81 STRING 36370105
CCT4 CCT6A â—¼   CORRELATES + 0.81 0.81 CCLE 31978347
CCT2 TCP1 â—¼   CORRELATES + 0.81 0.81 CCLE 31978347
PDHB PDK2 â—¼   PHYSICAL_INTERACTION 817.0 0.81 STRING 36370105
XPO1 CNOT2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26496610 26673895
PDK4 PDK2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
PDK4 SYNM â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
HSP90AB1 NR3C1 â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
AIP HSP90AA1 â—¼   PHYSICAL_INTERACTION 834.0 0.83 STRING 36370105
CEBPB SP1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 12665574 12847250 16651265
PPARG SP1 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
CCT3 CCT5 â—¼   CORRELATES + 0.84 0.84 CCLE 31978347
CCT8 PFDN5 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
CCT5 CCT7 â—¼   CORRELATES + 0.84 0.84 CCLE 31978347
PDK3 PDK2 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 33961781 28514442 32707033
PDK4 PDK3 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 33961781 28514442 32707033
CCT5 CCT8 â—¼   CORRELATES + 0.85 0.85 CCLE 31978347
CCT2 CCT3 â—¼   CORRELATES + 0.85 0.85 CCLE 31978347
PDK2 ODPA â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 11486000 27505672 12676647 11485553 34079125
NR1H4 PPARGC1A â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
CCT2 PFDN5 â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
CCT3 PFDN5 â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
CCT4 PFDN5 â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
CCT5 PFDN5 â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
CCT6A PFDN5 â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
CCT7 PFDN5 â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
PFDN5 TCP1 â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
CCT2 CCT7 â—¼   CORRELATES + 0.86 0.86 CCLE 31978347
CNOT11 CNOT7 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
DLAT PDHX â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
CCT2 CCT8 â—¼   CORRELATES + 0.87 0.87 CCLE 31978347
CNOT10 CNOT7 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
CNOT11 CNOT2 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
NCOR1 NR1H4 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
TRIM63 TTN â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
CCT6A TCP1 â—¼   CORRELATES + 0.87 0.87 CCLE 31978347
PDK3 PDHA1 â—¼   PHOSPHORYLATION ✅ - 0.87 0.87 Signor 11485553
ESRRA PPARGC1A â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
ESRRG PPARGC1A â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
HSP90AA1 HSP90AB1 â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
PDK3 ODPA â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 11486000 27505672 12676647 28514442 11485553 34079125
CNOT7 CNOT3 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 26344197 29395067 26186194 28514442
NR0B2 PPARG â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 16189514 19596656 11696534
CNOT1 CNOT11 â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
CCT6A CCT7 â—¼   CORRELATES + 0.89 0.89 CCLE 31978347
CCT6A CCT8 â—¼   CORRELATES + 0.89 0.89 CCLE 31978347
SP1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10547281 8657141 10850422
E2F1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15711575 12110166 18319725
ESRRA PDK4 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 16314495 18046414 18048642
ESRRA PPARGC1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23668787 16213225 21625432
ESRRG PDK4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17079227 23050013 19690166
FOXO3 TRIM63 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21798082 24920680 22531926
NCOR1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 22395773 20462215
NR0B2 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 24038081 16803864 11696534
NR0B2 SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20185821 20375098 21081708
SP1 NR3C1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12039077 14962081 15249123
PPARG NR3C1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 15531761
NR3C1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 15531761
NR3C1 STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16189514 8878484 9528750
PDK2 PDHA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16436377
PDK3 PDHA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16436377
PPARGC1A PDK4 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 16314495 18046414 18048642
SIRT1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15850715 21633182
SP1 SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23843607 20160399 23704280
CCT3 CCT6A â—¼   CORRELATES + 0.9 0.9 CCLE 31978347
SIRT1 FOXO3 â—¼   DEACETYLATION ✅ - 0.9 0.9 Signor 24003218
CCT2 CCT6A â—¼   CORRELATES + 0.9 0.9 CCLE 31978347
CCT4 CCT8 â—¼   CORRELATES + 0.9 0.9 CCLE 31978347
CCT3 CCT4 â—¼   CORRELATES + 0.9 0.9 CCLE 31978347
CCT5 CCT6A â—¼   CORRELATES + 0.91 0.91 CCLE 31978347
CNOT3 CNOT6L â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
PDHA1 PDHB â—¼   CORRELATES + 0.91 0.91 CCLE 31978347
CNOT3 CNOT2 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 5218748 16778766
CCT4 TCP1 â—¼   CORRELATES + 0.92 0.92 CCLE 31978347
DLAT PDHA1 â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
HSP90AA1 NR3C1 â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
PPARGC1A ESRRA â—¼   UP_REGULATES ✅ + 0.93 0.93 Signor 18074631
CCT4 CCT7 â—¼   CORRELATES + 0.93 0.93 CCLE 31978347
CCT7 TCP1 â—¼   CORRELATES + 0.93 0.93 CCLE 31978347
CCT8 TCP1 â—¼   CORRELATES + 0.93 0.93 CCLE 31978347
CCT3 TCP1 â—¼   CORRELATES + 0.93 0.93 CCLE 31978347
CCT3 CCT8 â—¼   CORRELATES + 0.94 0.94 CCLE 31978347
CCT7 CCT8 â—¼   CORRELATES + 0.94 0.94 CCLE 31978347
FOXO3 SIRT1 â—¼   PHYSICAL_INTERACTION 946.0 0.94 STRING 36370105
HSP90AB1 PTGES3 â—¼   PHYSICAL_INTERACTION 946.0 0.94 STRING 36370105
CNOT2 CNOT6L â—¼   PHYSICAL_INTERACTION 951.0 0.95 STRING 36370105
CCT2 CCT5 â—¼   CORRELATES + 0.95 0.95 CCLE 31978347
CCT3 CCT7 â—¼   CORRELATES + 0.95 0.95 CCLE 31978347
DLAT DLD â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
CNOT6L CNOT7 â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
DLD PDHB â—¼   PHYSICAL_INTERACTION 969.0 0.96 STRING 36370105
CNOT2 CNOT7 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
NCOR1 NR3C1 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
PDHB PDHX â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
CNOT1 CNOT6L â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
CNOT3 CNOT7 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
DLAT PDK3 â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
NCOR1 PPARG â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
HSP90AA1 PTGES3 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
DLD PDHX â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
DLAT PDHB â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
PPARG PPARGC1A â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
CCT2 CCT6A â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CCT3 CCT6A â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CCT4 CCT6A â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CCT6A CCT7 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CCT6A TCP1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CCT6A CCT8 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CNOT1 CNOT7 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
PDHA1 PDHB â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CCT4 CCT8 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CCT5 CCT6A â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CNOT1 CNOT2 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CNOT1 CNOT3 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CCT2 CCT3 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT2 CCT8 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT3 TCP1 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT3 CCT4 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT3 CCT7 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT4 CCT7 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT4 CCT5 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT7 CCT8 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT8 TCP1 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT2 CCT7 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT2 CCT4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT2 CCT5 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT2 TCP1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT3 CCT5 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT3 CCT8 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT4 TCP1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT5 TCP1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT5 CCT7 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT5 CCT8 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT7 TCP1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CNOT2 CNOT3 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
SP1 CAD â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 1346130 16675542 7905000 12746293
CEBPB PPARGC1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23564453 19491401 18467525 24353183
CEBPB PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 22473998 23934183 7557387 12524424 16431920 22610404 15110775 18694725 17242167 16054042 15158467 9950217 10862621 20829347
NR3C1 CEBPB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 25202013 9817600 9428795 11279134
CEBPB FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18391971 11893744
PDHA1 DLAT â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11752427 2188967 11935326 9242632
DLAT PDHA2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11752427 2188967 11935326 9242632
DLAT PDK3 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
DLAT PDK4 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
DLAT PDK2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDHX DLD â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11752427 2188967 11935326 9242632
PDHA1 DLD â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11752427 2188967 11935326 9242632
DLD PDHA2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11752427 2188967 11935326 9242632
DLD PDK4 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
DLD PDK2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
DLD PDK3 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
SP1 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9054613 12697671 10446910 18440323
E2F1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15711575 12110166 20971808
PPARGC1A ESRRA â—¼   PHYSICAL_INTERACTION 23.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16314495 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
PPARGC1A ESRRA â—¼   ENZYMATIC_REACTION ✅ 23.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16314495 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
NR0B2 ESRRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 11705994 15604093
PPARGC1A ESRRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 12181319 18063693 15337744 12522104 32296183 18441008 15100410
NR0B2 ESRRG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11705994 23331499 14963109 20516075 21459093
FOXO1 PPARGC1A â—¼   PHYSICAL_INTERACTION 5.0 1.0 ACSN 10364186 15668399 16122419 19449109 25464856
FOXO3 FOXO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19244250 16100571 18202312 23509296 19690465
FOXO1 PDK4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19703515 21081708 17079227 15047604 12820900
SIRT1 FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 24003218 22013015 14976264 18235501 15220471 14980222 22395773 15788402 15692560
FOXO1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16670091 12966085 17317207
FOXO3 SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23525956 20816089 15604409 23262029
SIRT1 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 24003218 14976264 14980222 15126506 21713995 15917664
PTGES3 HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 43.0 1.0 Omnipath 16565516 10642522 11447118 26804907 15916966 11413142 16403413 21988832 11812147 19875381 19740745 14761955 12077419 10811660 20039095 22806877 25036637 20048054 19996313 18285346 20661446 22315411 23022381 18172314 20159553 22729780 22504172 16289154 9817749 14987994 8114727
HSP90AA1 NR3C1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 32.0 1.0 Omnipath 16131566 8089152 10903152 26804907 31467278 8645634 15916966 24949977 21511880 19875381 9334248 12093808 16189514 20195357 24462205 10066374 14987994 8898375 8621522 8139547
PPARG NCOR1 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 11399519 11875494 15644117 16127449 17260466 17681149 17689680 21234400 23390297 6357187 8871614
PPARG NCOR1 â—¼   SHARES_COMPLEX 11.0 1.0 ACSN 11399519 11875494 15644117 16127449 17260466 17681149 17689680 21234400 23390297 6357187 8871614
SIRT1 NCOR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22395773 15175761 16713569
NCOR1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 15175761 11877444 15604093 16127449 11903058 22078880 23703729 9121466 21775429 17468099
NR1H4 NR0B2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 15817812 11705994 15692145 18842595 22345554 23546875 11030332 20185821 24498423 22683342 23607861 11518759
NR3C1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 24811171 27777311 10649448 8754811 11279134
PDHX PDHA1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11752427 2188967 11935326 9242632
PDHA1 PDK4 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDHA1 PDK3 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDHA1 PDK2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDK3 PDHA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 44.0 1.0 Omnipath 17081983 20166139 18767875 17474719 7782287 19415658 15302935 11485553 20068231 19341700 82003483 18691976 18088087 16436377 7273851 12676647 20058876 11486000 18212344
PDK4 PDHA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 48.0 1.0 Omnipath 17081983 20166139 18767875 17474719 7782287 19690332 19415658 15302935 11485553 19341700 82003483 18691976 18088087 16436377 17487921 7273851 12676647 18220336 11486000 19081061 18212344
PDK2 PDHA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 40.0 1.0 Omnipath 12676647 19415658 17081983 82003483 20166139 18767875 17474719 18691976 22910903 11485553 11486000 7782287 19341700 16436377 7273851 18212344 15302935
PDHA2 PDK4 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDHA2 PDK3 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDHA2 PDK2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDK4 PDHA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 16436377 14966024
PDHX PDHA2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11752427 2188967 11935326 9242632
PDHX PDHB â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11752427 2188967 11935326 9242632
PDHB PDK4 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDHB PDK3 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDHB PDK2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDHX PDK3 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDHX PDK2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDHX PDK4 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PPARG SP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16269451 15111490 15908479 11777901
PPARG PPARGC1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16513826 32991581 29182484
SIRT1 PPARGC1A â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 15205477 15744310 15989956 18687677 19590512 19960022
SIRT1 PPARGC1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23142079 21633182 19553684
SIRT1 PPARGC1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15744310 20640476 24003218 19553684