Protein list:

Seperate proteins by space | Example

Select nodes using shift click or drag to add to this list
Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

Note this may take some time with > 30 proteins
Filter Graph:

0.5
Layout:
  🔂

Click a node or edge for more data...
Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
PDHX AGTRAP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8153045 21516116
DLD GCSH â—¼   OXIDOREDUCTASE_ACTIVITY_ELECTRON_TRANSFER ✅ 2.0 0.8 Reactome 16263718 9242632
PDHX EWSR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
STAT5A INS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11415999 10373481
YY1 NR3C1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12039077 10030686
PAX6 PDHX â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12783165
YY1 PDHX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22951020
STAT5A PDK4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22698918 17360981
PDHB PDK2 â—¼   PHYSICAL_INTERACTION 817.0 0.81 STRING 36370105
HDAC6 EP300 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 15102857 19344692 12718889 22778253 23133622
FOXD4 PDK2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
FOXD4 PDK3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
PDK4 PDK2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
EP300 PCNA â—¼   PHYSICAL_INTERACTION 831.0 0.83 STRING 36370105
DLAT OGDH â—¼   PHYSICAL_INTERACTION 844.0 0.84 STRING 36370105
PAX6 CDX2 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 10506141
PDK3 PDK2 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 33961781 28514442 32707033
PDK4 PDK3 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 33961781 28514442 32707033
PDHB PDK1 â—¼   PHYSICAL_INTERACTION 851.0 0.85 STRING 36370105
DLAT PDHX â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
PDK1 PDK3 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
PDK3 PDHA1 â—¼   PHOSPHORYLATION ✅ - 0.87 0.87 Signor 11485553
PDHA1 PDK1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
PDK1 PDK2 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
EP300 YY1 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
EP300 PAX6 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10506141 35140242
PDHX PDK1 â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
CDX2 INS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16002547 7698771 12783165
DLAT GCSH â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 24256811 10103005 24341803
DLD GCSH â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 24256811 10103005 24341803
YY1 EP300 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22951020
EP300 HDAC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15102857 19344692
GCSH OGDH â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 24256811 10103005 24341803
PDHA1 GCSH â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 24256811 10103005 24341803
PDHX GCSH â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 24256811 10103005 24341803
GCSH PDHA2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 24256811 10103005 24341803
PDHB GCSH â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 24256811 10103005 24341803
STAT5B INS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10830280 10821852 10373481
NR3C1 STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16189514 8878484 9528750
PDK2 PDHA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16436377
PDK3 PDHA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16436377
PDK1 PDHA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16436377
PDK2 PDK1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 12573248 26496610 26186194 29568061 28514442 32707033 16189514
PDK2 PDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16189514 12573248
STAT5B STAT5A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15043997 17997837 14532269
STAT5A STAT5B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21542777 15043997 17997837
PDHA1 PDHB â—¼   CORRELATES + 0.91 0.91 CCLE 31978347
DLAT PDHA1 â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
DLAT DLD â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
DLD PDHB â—¼   PHYSICAL_INTERACTION 969.0 0.96 STRING 36370105
PDHB PDHX â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
DLAT PDK3 â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
DLD PDHX â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
DLAT PDHB â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
PDHA1 PDHB â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
PCNA EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 18263614 11268218 16713569
CDX2 GCG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9933606 17901057 11773447 14765989 17263687 10506141 16574312
PDHA1 DLAT â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11752427 2188967 11935326 9242632
DLAT PDHA2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11752427 2188967 11935326 9242632
DLAT PDK3 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
DLAT PDK1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
DLAT PDK4 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
DLAT PDK2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDHX DLD â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11752427 2188967 11935326 9242632
PDHA1 DLD â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11752427 2188967 11935326 9242632
DLD PDHA2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11752427 2188967 11935326 9242632
DLD PDK4 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
DLD PDK1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
DLD PDK2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
DLD PDK3 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
EP300 STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 21988832 14726487 15509516 9989503 9773981 26504087
EP300 YY1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11486036 7758944 18542060 9199306 17510411
NEUROD1 GCG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15906379 21824254 20592023 19223471 9685329
PAX6 INS â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 22426149 15047618 22974359 15180990 20943817 22403172 22764048 12426319 18199433 11845228 9224716 10891400 21983268 9230347
NEUROD1 INS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 10636926 20943817 17449132 18252719 12665509 15797719 15944145 19619559 15906379 12684063 22172402 15993959 8552091 12426319 16825292 17927952 17259388 19264802 11799123 15664997 15862113 23927931 24732800 9685329 18035054 11756538 17569705 17785922 16461554 10545951 22974359 17299998 16186386 20616010 21084850 15650322 17300753 16055439 11549279 19689288 9230347
PDHX PDHA1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11752427 2188967 11935326 9242632
PDHA1 PDK4 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDHA1 PDK3 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDHA1 PDK2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDHA1 PDK1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDK1 PDHA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 45.0 1.0 Omnipath 17081983 20166139 18767875 17474719 7782287 19415658 15302935 11485553 20068231 19341700 22195962 82003483 18691976 18088087 16436377 7273851 12676647 20058876 11486000 18212344
PDK3 PDHA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 44.0 1.0 Omnipath 17081983 20166139 18767875 17474719 7782287 19415658 15302935 11485553 20068231 19341700 82003483 18691976 18088087 16436377 7273851 12676647 20058876 11486000 18212344
PDK4 PDHA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 48.0 1.0 Omnipath 17081983 20166139 18767875 17474719 7782287 19690332 19415658 15302935 11485553 19341700 82003483 18691976 18088087 16436377 17487921 7273851 12676647 18220336 11486000 19081061 18212344
PDK2 PDHA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 40.0 1.0 Omnipath 12676647 19415658 17081983 82003483 20166139 18767875 17474719 18691976 22910903 11485553 11486000 7782287 19341700 16436377 7273851 18212344 15302935
PDHA2 PDK4 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDHA2 PDK3 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDHA2 PDK1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDHA2 PDK2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDK4 PDHA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 16436377 14966024
PDHX PDHA2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11752427 2188967 11935326 9242632
PDHX PDHB â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11752427 2188967 11935326 9242632
PDHB PDK1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDHB PDK4 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDHB PDK3 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDHB PDK2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDHX PDK3 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDHX PDK2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDHX PDK4 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDHX PDK1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000