NEK7
|
DRC7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
SPRED2
|
NEK7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
MAVS
|
NEK7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
ISY1
|
NEK7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
MMAB
|
NEK7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
USP12
|
NEK7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
RASSF2
|
NEK7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
RBM5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
GJA5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
GNAO1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
PSAT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
NXPE1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
KLRC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
SLC25A11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
ZHX1-C8ORF76
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
PYGO1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
POC1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
FAHD2A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
EGFL8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
THAP7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
SPATA17
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
IDH1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
MYNN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
TDO2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
SP6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
TRNAU1AP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
DNASE1L1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
RBM17
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
TUBB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
RAP1B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
HSD3B1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
RAB31
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
PSMD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
FUT2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
MAGEA2B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
PRAM1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
HLA-DRB3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
THBS3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
CNOT3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
MFI
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
EVA1B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
MYBPHL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
EPCAM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
PPEF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
PSMC4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
LEG1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
PIAS4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
LGALS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
C1ORF216
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
TPX2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
RAB3C
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
KIF14
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
28630147
|
RECQL4
|
APEX1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19567405
|
LUC7L2
|
NASP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16169070
5217955
|
APEX1
|
TNF
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19376732
17637837
|
DDIT4L
|
P4HB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
EML4
|
NEK6
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
16890222
31409757
|
MAVS
|
NLRP3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
25816776
24048902
|
NLRP3
|
PYCARD
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
5215008
11786556
|
P4HB
|
PLK4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
SUMO2
|
PIAS4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
15383276
5217202
|
XRCC5
|
PIAS4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
7986053
19779455
|
UBE2N
|
SUMO2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
22661230
22635276
|
LAMP3
|
NEK7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
33961781
28514442
|
TNFA
|
NEK7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
26186194
|
ZN669
|
NEK7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
33961781
28514442
|
ZN669
|
ANKS3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
33961781
28514442
|
ANKS3
|
NEK8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
33961781
27173435
|
SRPK2
|
CPSF6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
33961781
23602568
|
SMC1A
|
CTCF
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
33196849
18219272
|
LAMP3
|
NEK6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
33961781
28514442
|
LUC7L
|
LARP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
26186194
|
PARK7
|
PRDX6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
31536960
29128334
|
TKT
|
PGK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
24981860
26344197
|
NEK7
|
EMAL4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
27173435
31409757
|
MAVS
|
NALP3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
23582325
26494172
|
DYL1
|
NEK7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
27173435
32707033
|
NEK7
|
NEK8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
27173435
32707033
|
NEK7
|
PDIA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
27173435
32707033
|
AHSA1
|
FKBP4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
25036637
22504172
|
PIAS4
|
SUMO2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
841.0
|
0.84
|
STRING
|
36370105
|
ANKS3
|
ANKS6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
843.0
|
0.84
|
STRING
|
36370105
|
NEK6
|
NEK7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
847.0
|
0.84
|
STRING
|
36370105
|
ANKS3
|
NEK7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
33961781
27173435
32707033
|
ANKS6
|
NEK7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
33961781
27173435
32707033
|
PRDX6
|
PCNA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
26030842
20849852
|
PCNA
|
APEX1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
10559261
11601988
16189514
|
P4HA2
|
NEK7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
28514442
27173435
|
NEK6
|
EMAL4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
31409757
17353931
|
PYCARD
|
CASP1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.86
|
0.86
|
mint
|
34589402
|
HDAC2
|
RREB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
21258344
23752268
|
PGK1
|
PCNA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
26030842
20849852
|
NEK7
|
NALP3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
34512673
32814053
31189953
31762063
26814970
31866999
|
NEK9
|
DYL1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
33961781
27173435
20562859
25852190
26496610
|
NEK6
|
DYL1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
32707033
17353931
|
NEK8
|
ANKS6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
27173435
32707033
26638075
|
NLRP3
|
PYCARD
|
â—¼ PHYSICAL_INTERACTION
|
|
|
884.0
|
0.88
|
STRING
|
36370105
|
P4HA2
|
P4HB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
886.0
|
0.88
|
STRING
|
36370105
|
NCAPD2
|
SMC4
|
â—¼ CORRELATES
|
|
+
|
0.89
|
0.89
|
CCLE
|
31978347
|
NEK9
|
NEK7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
33961781
27173435
20562859
12840024
32707033
|
SRPK2
|
LUC7L
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
33961781
26186194
26167880
28514442
23602568
34133714
32707033
|
NEK9
|
NEK6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
33961781
17353931
20873783
12840024
26186194
12101123
28514442
32707033
|
MSH2
|
PCNA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
909.0
|
0.9
|
STRING
|
36370105
|
UBE2N
|
UBA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.91
|
0.91
|
HIPPIE
|
27173435
14517261
29537486
18678647
30097011
27182664
25527291
33619271
31638574
|
UBA1
|
UBE2N
|
â—¼ PHYSICAL_INTERACTION
|
|
|
919.0
|
0.91
|
STRING
|
36370105
|
NEK7
|
NEK9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
928.0
|
0.92
|
STRING
|
36370105
|
PCNA
|
MSH2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.94
|
0.94
|
HIPPIE
|
8858149
16189514
12171929
15225546
|
RECQL4
|
SLC1A5
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.95
|
0.94
|
PKG
|
28854368
|
TRIM25
|
UBE2N
|
â—¼ PHYSICAL_INTERACTION
|
|
|
948.0
|
0.94
|
STRING
|
36370105
|
P4HA2
|
PDIA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.96
|
0.96
|
HIPPIE
|
33961781
27173435
26344197
7753822
26186194
30021884
|
NEK7
|
NLRP3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
974.0
|
0.97
|
STRING
|
36370105
|
CASP1
|
PYCARD
|
â—¼ PHYSICAL_INTERACTION
|
|
|
978.0
|
0.97
|
STRING
|
36370105
|
NCAPD2
|
SMC4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
991.0
|
0.99
|
STRING
|
36370105
|
PSMC4
|
PSMD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
997.0
|
0.99
|
STRING
|
36370105
|
PSMD14
|
PSMD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
997.0
|
0.99
|
STRING
|
36370105
|
PSMC4
|
PSMD14
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
UBE2N
|
PCNA
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
12.0
|
1.0
|
ACSN
|
10880451
16224103
16518696
17652783
18157158
18196958
18525240
18647995
19217833
19258535
19851286
20675655
|
UBE2N
|
PCNA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
22.0
|
1.0
|
Omnipath
|
18772547
12820959
18525240
19459846
19258535
19440234
17652783
15147722
10880451
15169778
19851286
10722742
18647995
18006823
18157158
16224103
20675655
16518696
18196958
15340381
10721693
|
NEK9
|
NEK7
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
19369195
18691976
12840024
18452278
|
NEK7
|
NLRP3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
34512673
32814053
26814970
31189953
|
CASP1
|
PYCARD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
18.0
|
1.0
|
Omnipath
|
24630722
25605870
12191486
15383541
11051551
11967258
11536016
24803432
21385879
26121674
11432859
12019269
16585594
19337385
14634131
|
SBF1
|
GDI2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
12.0
|
1.0
|
Reactome
|
27246931
22171327
16754960
16525121
15561770
26925400
22648168
27103185
25648148
18804435
22705394
19745841
|
NEK9
|
NEK6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
22.0
|
1.0
|
Omnipath
|
17145710
12840024
26186194
17353931
19369195
19690332
12101123
20873783
|
PYCARD
|
NLRP3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
11.0
|
1.0
|
ACSN
|
11989976
17959595
19104081
20385749
23202296
23702978
26885855
27048821
27066895
27439607
27984721
|
PYCARD
|
NLRP3
|
â—¼ SHARES_COMPLEX
|
|
|
11.0
|
1.0
|
ACSN
|
11989976
17959595
19104081
20385749
23202296
23702978
26885855
27048821
27066895
27439607
27984721
|
PYCARD
|
NLRP3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
ACSN
|
11989976
17959595
19104081
20385749
23202296
23702978
26885855
27048821
27066895
27439607
27984721
|
P4HA2
|
P4HB
|
â—¼ OXIDOREDUCTASE_ACTIVITY_ELECTRON_TRANSFER
|
✅
|
|
4.0
|
1.0
|
Reactome
|
2543975
16591531
1323838
14500733
|
XRCC5
|
UBE2N
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
22179609
11493912
9512523
11604075
12947387
|
RECQL4
|
NEK7
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.13
|
1.13
|
PKG
|
28854368
|
RECQL4
|
RECQL4
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-2.61
|
2.61
|
PKG
|
28854368
|
MSH2
|
MSH2
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-6.48
|
6.47
|
PKG
|
28854368
|