Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
TP53 CASP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21859926 16177095
AR CASP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16007156
CASP2 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16189514 11399776
HTT CASP3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HTT CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16777606 10770929
CASP3 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17899380
CASP3 ITGB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17178732
EP300 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23403292 24998469
MAPK3 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24530506
HINFP TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8153045 21516116
TP53 HMOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24366007 21552291
SREBF1 HMOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17452746
SREBF2 IDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12923220
MAPK1 ARRB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16580177 9924018
AR MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14619959 20610535
MAPK1 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15263086 15466214
MAPK1 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8941362
MAPK3 ARRB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16580177 9924018
TP53 MAPK3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21187340 16050810
MAPK3 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15263086 15466214
PARK7 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TP53 PARK7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23447676 23149933
HLA-DPA1 SEC24C â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11790530 2391366
HDAC3 TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16847267 0510834103
AR TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19481544 7103716
TP53 HSPA5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17184779 5219502
TP53 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10823891 5212595
AURKA TP53 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 14702041 19121998
TP53 SMAD3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21900401
TP53 TRRAP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12138177 11779500
TP53 EGR1 â—¼   COLOCALIZATION 2.0 0.8 intact 5216887 14744935
TP53 CASP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
MED15 FHL3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
FHL3 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FHL3 FHL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11135358 5213377
FHL3 FHL2 â—¼   PROXIMITY 2.0 0.8 intact 11135358 5213377
NFYC NFYB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5215853 12401788
RAN HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
USF1 APOA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9880489
SREBF2 EBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12855700
HNF4A EBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12855700
SMAD3 MED15 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12167862 5215637
AR SMAD3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20739403 20610535
CREB1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16862174
NR0B2 HDAC3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17895379 0706736104
LDLR CREBBP â—¼   ACETYLATION ✅ 2.0 0.8 intact 6804160 18660751
SREBF2 KPNB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10397761 31875875
SREBF1 KPNB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10397761 31875875
SREBF2 SP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5212972 10976766
SP1 FHL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16624878 0602109103
SP1 EGR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20121949 7384875
SP1 SND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23160072 17350600
NR0B2 EGR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 24619556 21725089
EGR2 EGR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9915863 18203138
EGR1 SREBF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22292946 18068676
EGR1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17011549 12890669
ATF6 MBTPS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21355074 17307147
ATF6 MBTPS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17307147 23884247
HTT CREB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CREB1 G6PD â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17273168 20103717
CREB1 CYP51A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12145339 16123160
UBE2I HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
UBE2I ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
NR5A2 UBE2I â—¼   SUMOYLATION ✅ 2.0 0.8 intact 17036045 5219211
PSMD4 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HLA-DPA1 SEC23A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11790530 2391366
SREBF2 RAB11B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
STAR HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FASN HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TTC1 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CASP7 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HTT SREBF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SEC24A HLA-DPA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11790530 2391366
VAPA OSBP â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
HNF4A AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16474850 12466965
AR HSPA5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20610535 21125667
AR ABCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15520169 20610535
AR FHL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20610535 17975004
AR SCAP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15133039
SEC24B HLA-DPA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11790530 2391366
ITGB4 ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
ZYX ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
SREBF1 ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
RNF139 ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FHL2 ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
FDPS ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
ACOT7 ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
ATXN1 SREBF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ATXN1 MED15 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
ATXN1 FDPS â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NR1H3 PCK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23633563 12697904
NR1H2 ABCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25838426 20951680
NR1H4 MTTP â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15337761 20699090
USF1 NR0B2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19720831 21147283
USF1 NFYA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21770893 12697323
USF1 PCK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19720831 20461355
HNF4A LDLR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21123766
HSPA5 LRP1B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
NFYA HSPA5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22530004
HSPA5 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11943137
SREBF2 HNF4A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12855700 5216527
NR5A2 HNF4A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12069850 10799577
HNF4A ABCG5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21123766
HNF4A PCSK9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21123766
NR1H4 NR5A2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11518759 11030331
NR1H4 PON1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16269825 16284190
NR1H4 CYP8B1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17720959 18323469
NFYC NFYA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12857858 22969033
NFYA HMGCS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7665553
NFYA STAR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11250933 11861536
SREBF1 G6PD â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12177166 19062325
CASP7 ITGB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17178732
ABCG8 ABCG5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16870176 5218866
CASP1 SREBF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16990137
CASP1 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18667412
SREBF2 INSIG1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15073165
RNF139 INSIG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20068067
SREBF1 INSIG1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15073165
SCAP SREBF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12202038 12242332
SCAP SREBF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10896675 12202038
SREBF1 NR0B2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15123650
NR0B2 ABCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12198243 22424975
SEC24D HLA-DPA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11790530 2391366
HLA-DPA1 SAR1B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11790530 2391366
SREBF1 SND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 29296233
SREBF2 SND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 29296233
SREBF2 UCP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19082571 24417972
SREBF1 FDPS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8798690 9651391
SREBF1 SQLE â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17027328 12083769
SREBF1 PCYT2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11483628
SREBF1 HMGCS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9651391
NPAT CASP8AP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17003125 0604227103
SREBF2 STARD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15760897
SREBF2 HMGCS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12177166 23709690
SREBF2 PCYT2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11483628
RAN UBE2I â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
CREB1 TP53 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
HNF4A SP1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 15651981 16713569 19115260
NR1H3 EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 25962847 33742100
USF1 FHL2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
ZNRF4 SCAP â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
NFYC PON1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
ZNRF4 ABCA3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
EGR1 TP53 â—¼   PHYSICAL_INTERACTION 828.0 0.82 STRING 36370105
NFYB EP300 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 10075648 9799238 15454570
FHL3 ZYX â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
TTC1 VAPA â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 25036637 26496610 33961781 26186194
MED1 NR1H2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 26120082 15604093
NR1H2 ABCA1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 23931754 25838426 20951680
PIAS2 TP53 â—¼   PHYSICAL_INTERACTION 834.0 0.83 STRING 36370105
EP300 RAN â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 12649209 33742100
HINFP NPAT â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 14585971 15988025 22288532
HDAC3 NR0B2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 15835920 17895379
EGR1 SP1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 20121949 12569082
SCAP SREBF2 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
SCAP SREBF1 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
EGR1 EP300 â—¼   PHYSICAL_INTERACTION 850.0 0.85 STRING 36370105
EP300 SMAD3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9679056 15824515 15688032 16109717 15345715 20564330 9843571 15133024 10497242 17469184 15623506 10575014 15588252 18055455 16876108 21567395 11134049 12743039 11058129
MED6 MED15 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 14983011 14657022 26344197 24981860
AR SP1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
MED1 MED6 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
INSIG1 SCAP â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CREBBP HTT â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
HMGCR INSIG1 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
SEC24C SEC24D â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
PIAS1 TP53 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
COPS5 TP53 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
AURKA TP53 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
MAPK1 TP53 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
SP1 EP300 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15647279 19062177 10651903 11517158 23714681 10899165 16478997 11030335 24530506 34252870 28425985 31536933 32115405 17623675 10362258 16734381 17906698 22415975 12200149
FHL3 FHL2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11135358 16713569 11046156
SMAD3 PIAS3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16189514 14691252
MED1 MED15 â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
MED1 HNF4A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 12101254 12089346
AR EP300 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
CREBBP SMAD3 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
MAPK1 MAPK3 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
MED15 SREBF1 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
HNF4A NR0B2 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
CREB1 EP300 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
SP1 SMAD3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11432852 10878024 12228247 22227581 16714330 11114293
NR0B2 NR1H2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12198243 16189514 27485016
NR0B2 HNF4A â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16455805 11535594 20516075 28128295 16488887 15604093 10594021
SCAP SREBF2 â—¼   RELOCALIZATION ✅ + 0.89 0.89 Signor 12202038
SEC24A SEC24D â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
AR CASP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16007156
AR CASP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22038727 20610535 23554843
EP300 EGR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15225550 9806899 20089040 20018936
AR HMOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11965035 20610535
SREBF1 IDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23011765 12923220
SREBF1 LRP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20980003
MAPK1 PCYT1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15788406
MAPK3 PCYT1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15788406
UBE2I PARK7 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11477070 15976810 18339323
PIAS2 PARK7 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12526767 16189514 11477070
SEC24C SAR1B â—¼   GTPASE_REACTION ✅ 3.0 0.9 Reactome 10982397 10825291 17316621
TP53 FHL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18615633 11062252 22796152
TP53 PIAS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 24584189 11877452
TP53 HSPA5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15212714 20097177 18840615
NFYB NFYA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 32296183 25416956 12857729 23332751 26496610 14681455 8051128 26344197 15243141 15831478 17098936 16959611
SP1 EBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11139605 20506344 17273900
HDAC3 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16528103 18241676
CDK8 MED1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 32707033 18418385 15989967 29568061 10024883 26496610 20098423 23322298 33961781 24981860 26186194 23602568 10198638 11867769 10882111
CDK8 MED15 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 18418385 26496610 20098423 33961781 24981860 26186194 23749998 23602568 32707033 14657022 29568061 20720539
SP1 ACLY â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11989980 10618488 10801800
SP1 HTT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22399227 20018729
SP1 PCK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14744869 19329064
EGR1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15517885 12890669
MBTPS2 ATF6 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 15299016 10564271 11163209
ATF6 MBTPS1 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 15299016 10564271 11163209
HSPA5 ATF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18624755 31226023
UBE2I CASP8AP2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 21338522 19615980 23673342
AR PIAS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20610535 18656483 10628744
SEC23A SAR1B â—¼   GTPASE_REACTION ✅ 3.0 0.9 Reactome 10982397 10825291 17316621
SEC24A SAR1B â—¼   GTPASE_REACTION ✅ 3.0 0.9 Reactome 10982397 10825291 17316621
SREBF1 CYP51A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12145339 16123160 10551787
AR NR5A2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21273442 20610535 23689136
AR SREBF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20610535 16541421
SEC24B SAR1B â—¼   GTPASE_REACTION ✅ 3.0 0.9 Reactome 10982397 10825291 17316621
NR1H3 NR0B2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12198243 16189514 27485016
NR1H2 NR1H3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12470667 11875109 22194611
NR1H3 DHCR24 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18815215 23359226 23416078
SREBF2 MTTP â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10455139
MED1 MED6 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 18391015 15989967 33961781 24981860 22939629 20133760 26344197
MED1 MED15 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 18418385 15989967 20098423 33961781 24981860 14657022 20133760 26344197
USF1 ABCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11839742 11861672
PCSK9 LDLR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 18250299 22081141 25613181 18753623 17435765 23085658
HNF4A ABCG8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21123766 17403900
NR5A2 CYP8B1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10747975 18323469 12069850
SREBF1 HMGCR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9651391 18413311
ABCG8 ABCG5 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12208867 16870176 27144356
SREBF2 CASP7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19323650
SREBF1 CASP7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19323650
SREBF2 ACLY â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10777536 10801800
SREBF2 LRP1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16697011
SREBF2 FDPS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12177166 20450493
SREBF1 STAR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11145563 11250933 11861536
SREBF2 FASN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12177166 16007182 18413311
SREBF2 ACOT7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16335799
SEC24D SAR1B â—¼   GTPASE_REACTION ✅ 3.0 0.9 Reactome 10982397 10825291 17316621
SEC24A SEC24C â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
CDK8 MED6 â—¼   PHYSICAL_INTERACTION 904.0 0.9 STRING 36370105
CDK8 MED15 â—¼   PHYSICAL_INTERACTION 909.0 0.91 STRING 36370105
OSBP VAPA â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
EP300 SP1 â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
EP300 TP53 â—¼   POLYUBIQUITINATION ✅ - 0.91 0.91 Signor 12690203
CDK8 MED1 â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
TP53 UBE2I â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
SP1 NFYA â—¼   PROTEIN_INTERACTION 0.93 0.93 HIPPIE 30392062 10393239 15647279 10446910
EP300 SMAD3 â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
SP1 TP53 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
CREB1 EP300 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 12665587 21268077 10506141 21212407 11313407 7870179 17476304 22787115 26944191 33846793
SEC23A SEC24C â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
ABCG5 ABCG8 â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
PIAS2 UBE2I â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
SEC23A SEC24B â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
PIAS1 UBE2I â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
NFYC NFYB â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 32296183 21988832 26496610 35140242 33961781 20936779 9388234 12401788 26344197
MED6 CDK8 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 32707033 29568061 10198638 10024883 15808511 26496610 11416138 33961781 24981860 26186194 23602568 14983011 26344197 11867769 10882111
NR5A2 NR0B2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 22504882 11668176 20516075 14963109 21566081 12198243 20375098 21262773
NFYC NFYA â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 32296183 12857729 14681455 35140242 33961781 20936779 26186194 15243141 26344197 23332751
LDLR PCSK9 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
NR0B2 NR5A2 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
TP53 EP300 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 16611888 6599495
CREBBP TP53 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
CREB1 CREBBP â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
SEC23A SEC24A â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
SEC23A SEC24D â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
NFYA NFYB â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
KPNB1 RAN â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
NFYA NFYC â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
EP300 TP53 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
NFYB NFYC â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CASP3 CASP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9261102 9922454
TP53 CASP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 22154326 22178888 23677569 15578696 17363498 24098340 18064040 23527225 10893263 21859835
CASP3 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 8626669 9535906 16713569 9208847
EGR1 EP300 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20414733 18798221 15635605 15225550
MAPK1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17623675 24530506
EP300 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11971970 10779504 24480624 17011549 16713569
EP300 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 137.0 1.0 Omnipath 11907332 25545885 21187340 10706102 16438982 10490106 19339993 15542844 23010591 11433299 19608861 17438265 17906639 16024799 9194564 20234175 23402884 12162806 26229107 16959611 15186775 9744860 11070080 17977830 17189186 22266186 20228809 15664194 19805293 25753752 11804596 26625199 27818144 10648616 16928824 9288740 10942770 12724314 23148227 23728348 15965232 19218448 16678111 16782091 20094059 14612423 24821727 10518217 16713569 9891054 25288747 17452980 14759370 19788416 25156994 18931695 22074660 23880760 15337767 15509808 26302407 22731250 18391200 16543236 19234109 21471221 23307557 25867071 12690203 15558054 18612383 23870121 18243116 19217391 22013068 16537920 16611888 18485870 9194565 12660246 9809062 23796514 11359905 12501250 15295102 19407812 25651062 23329847 16135789
EP300 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 9843571 11134049 12743039 15133024 15824515 15623506 16876108 21567395 16109717 17074756 20564330 10497242 15588252 17469184 15345715 11058129 10575014 16862174
HINFP NPAT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17163457 19170105 19590016 17096384 17974976 14585971 17577209
NPAT HINFP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 22288532 18850719 17974976 14585971 15988025
CREB1 HMOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17313370 19534727 14523007
USF1 HMOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 7969144 8760880 18331200 15242350 2318208 2722866
SREBF2 LRP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20980003 24529141 16697011
FGF19 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MAPK1 SMAD3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 10197981 16156666 27153775 29577978
SP1 MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12220517 16797880 20506264 20121399 20882567 18372343 10727414 21170990 17889508
MAPK1 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12975377 23602568 16424009 19058874 23397142 21707490
MAPK1 MED1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12356758 15212693 16314496
MAPK1 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 19318349 20882567 16377629 18775330 8226933 14744793 16079281 11904305 9604935 15212693 14593115 8388392
MAPK1 SREBF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10627507 10915800 18669648
MAPK1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 53.0 1.0 Omnipath 19218245 18032789 18729074 16156666 19914161 23331499 19914168 24080014 8226933 14512875 15520018 20736297 26497676 12193595 26297431 18988627 8388392 10197981 15241418 18775330 9604935 9380693
MAPK1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 18511414 9725910 10318905
MAPK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 14965474 9765199 15116093 21675959 23443559 10781582 25241761 10446957 10958792 11409876 11709713 21147777 10673501 11551930 15867353 11875057 12091386
MAPK1 ARRB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 19651622 19153083 18767875 17322306 15456867 10347142 20068231 19413330 9388255
MAPK1 SREBF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10627507 14988395
FGF19 MAPK3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MAPK3 SMAD3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 10197981 16156666 27153775 29577978
MAPK3 SREBF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10627507 14988395
MAPK3 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 32205409 20150555 21983342 11904305 14593115 18199680 8226933 14744793 16079281 19318349 20882567 22266860 28574228 21097497 8388392 32615164 16377629 19245816 18775330 9604935 15212693
MAPK3 SREBF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10627507 10915800 18669648
MAPK3 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 10781582 11239457 10958792 28937686 9467949 10348343 24194938 9739174 16713569 12955074 10747897 17237827 25767119 18523266 12393879
MAPK3 ARRB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 25.0 1.0 Omnipath 19651622 19153083 18767875 17322306 15456867 10347142 20068231 19413330 9388255
MAPK3 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23331499 10197981 15241418 24080014 18775330 8226933 16156666 9604935 12193595 8388392
MAPK3 MED1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12356758 16314496
AR PARK7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12612053 17510388
EGR1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9242687 17822668 15958557 12755686 16990849
TP53 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 19057620 15632413 11466559 19448667 19880525 9891054 22198284 10833421 11709699 10435630 11390631 9890939 21191649 12501250 11928223 17434128 12164786 24330748 11779500 10435595 21513889 10777477
TP53 HTT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22399227 15996546 16978870 16278683
TP53 FASN â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12734185 19861536
TP53 HNF4A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11818510 16895524
TP53 NFYA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9249061 12403781 21683812 12167641 18372207
TP53 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17202838 18084622 18945670 11504717
TP53 SP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 19846904 15790310 11118296 11384995 21611785 7478550 15967108 18419600 19244234 9865734 18769160
TP53 CASP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16135520 12459463 15580302 21943362 11278253
MED1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 15848166 9444950 16713569 11118038
CREB1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16611888 25241761 21295542
EGR1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15225550 14744935 11251186 16713569 12384981
PIAS1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 25241761 15133049 10380882 20805487 11867732 16713569 11583632 11788578
AURKA TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 50.0 1.0 Omnipath 24173284 22864622 25217103 24089029 16713569 19413330 25848977 17999753 23565200 25333414 23201157 16552184 10884347 1956339 26186194 29455673 15469940 15749021 18974145 21502403 17287340 28043820 22396649 92065884 12198151 27933271 22852086 12064478 30266789 25398437 17259342 22350019 25634113 14702041
CREBBP TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 49.0 1.0 Omnipath 17303408 25545885 27618436 19220000 16713569 10823891 15632413 19805293 25451029 15279786 10473588 12154097 7575488 16537920 10848610 18485870 19880525 10648616 20144767 14722092 14759370 18590585 26976603 9194564 19788416 25314079 19166313 12426395 9288775 11782467 17660363 19234109 21390126 10196247 17434128 19357310 10551785 22084066
TP53 NFYA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17145710 16959611 15831478
TP53 NFYB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17145710 16959611 11096075 15831478
TP53 HTT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18431400 32814053 16713569 10823891
SP1 NFYB â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 18654640 9748295 9604010 18559965
NFYB SREBF1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 12177166 18559965 9748295 18654640 8798690 20450493
NFYB SREBF2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 12177166 18559965 9748295 18654640 8798690 20450493
RAN AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10400640 16713569 18565325
RAN KPNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 17145710 10779340 8909533 11024021 9214382 20658144 8576188 26496610 9102465 9135132 10944119 10037787 9045717
HNF4A APOA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8369280 1639815 9880489
INSIG2 SCAP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 12482938 12242332 34192549 16549805
SMAD3 SP1 â—¼   PHYSICAL_INTERACTION 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
SMAD3 SP1 â—¼   SHARES_COMPLEX 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
SMAD3 SP1 â—¼   ENZYMATIC_REACTION ✅ 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
CREBBP SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 15849193 10497242 15467747 18003620 9679056 15990875 15750622 19589780 17074756 17283070 9679060
KPNB1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11294908 10846168
PIAS3 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 16189514 14691252
CDK8 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19914168 19914161
SMAD3 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 23331499 11248024 11280774 12226080 16713569 11707452
SP1 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23297421 20096088 9765204 21191649 21464950 12200429 20130956 12169688 15576380 15184875 15713621 18571793
AR CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9822653 15350180 16492776 16344550 11161315 18819102 18031230 20610535
CREB1 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 47.0 1.0 Omnipath 10866654 18599546 15585582 7870178 8028671 11313407 16007092 8413673 11564156 15691881 9829964 15073328 20403362 11259575 17476304 17707401 20541704 16799563 7870179 11123304 27789289 7913207 12933667 8663317 8004670 11483993 12198160 9413984
HTT CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 11264541 11607033 16456924 15994095 17500595 16713569 10823891
CREBBP SREBF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 9651391 16799563 10235267 9765204 8918891
CREBBP AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 20541699 9822653 15691881 12810069 9482849 16713569
SP1 NFYA â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 18654640 9748295 9604010 18559965
SP1 NFYC â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 18654640 9748295 9604010 18559965
SP1 SREBF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 19716432 20971080 20179320 24458133 18068676 17449871 15462672 21696544 15330762 22511764
SP1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 8864062 16928829 16704988 23662037 10773882 9353275 15661808 17984071 18430409 22347450 20739403 8994183
SP1 EGR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20427719 18044710 9282327 8349585 10826704 10082539 12637574
SP1 LDLR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 24358207 14568562 7836375 11250935 10894816 9610768 11792717 16647292 7597088 14998783 7627719 10841543 16303770 9271397 10224053 16449644
SP1 HNF4A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19540905 15651981 23307400
SP1 NFYA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 19564345 12153142 10748033 16442295 23160377 12502798 10542271 9516473 22154511 12697323
SP1 PCYT1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10216289 12794070 16484221 20096375 10744779 17384411 16157598 15247247
SP1 STAR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11250933 11111087 15129808 10919277
NFYA SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10393239 12427542 10446910
SP1 SREBF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16713569 18068676 10224053
EGR1 LDLR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12235180 16563127 12947119
EGR2 SREBF2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 8619637 11394999 21044070 15836632 20149798
AR ATF6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20610535
ATF6 HSPA5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 19667116 22189555 10856300 19622751 20165829 10866666 17117415 12076252 14973138 15899857 17241871 20801537 11256944 16452489 17522056 10564271 12713871
CREB1 STAR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 12790807 17065415 24708239 12933667 19282384 15550512 12530631 18583320
CREB1 PCK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 21406501 20688914 10854692 20022930 1655770 16803882 8093246 20797423 20137375 24046422 10085123 23058912 9593667 8386317 11092886 19583954
AR UBE2I â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10383460 8798622 19692572 12764129
UBE2I AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10383460 8798622 19692572 12764129
AR VAPA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20610535
AR STAR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 14673133 17065415 11595506 20537519 14630719 17400803 20924043 21971485 15590903 18974265 17909266 12943700 9801462 25001622 10403575
AR MED1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17483314 21593191 24778216 23887938
NR0B2 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 16713569 11735420
FHL2 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17192406 10654935 16713569
PIAS2 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11117529 9920921 12177000 16713569 11477070 12764129
CASP1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9535906 16713569
CASP7 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9535906 16713569
SREBF1 FDFT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9575211 11111077 9748295 11008488 18413311
SREBF2 FDFT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11008488 18413311 11111077 9575211
NR1H3 FASN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 19378344 22160584 20005944 11287605 22183856 17522048 22641099 23499676 24265317 11790787 19903962
NR1H3 ABCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 45.0 1.0 Omnipath 12032171 19718435 17587765 15280160 12198243 21219878 11788472 11641412 15292368 16141411 14764426 22305277 23466610 24603323 22429094 15922656 22389325 15171719 21521932 15949682 19342446 22683903 23523156 17526932 18580406 16254209 16901265 18372238 11287605 17887732 20570635 15774904 16099444 10858438 11264984 19787078 17026988 22711909 23686490 16803904 16730733 19201410 17135302 19258656 20419060
NR1H3 SREBF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 18854425 19366697 16831124 19933273 24277692 18202130 20868688 16112614 26120082 15855229 12730331 24265317 21094755 22511764 19716432 21266776 11287605 11694526 18420801 22984430 18684130 24458133 21540177 21979752 19258656 15330762
NR0B2 NR1H3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 16189514 12198243
NR1H2 SREBF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16644917 11287605 16825483 19258656 26120082
NR1H2 ABCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15831500 16141411 15292368 23523156 16644917 20951680 16825483 21507939 19258656
NR0B2 NR1H2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12198243 23331499 16189514
USF1 FASN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 11583420 7499393 17313375 9594578 10962028 10103003 17197698 9334210 12440974 19303849 24511897 12897158
SREBF2 LDLR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 12177166 19808779 11149418 12149270 22593575 20936497 10455139 11234460 24770487 21123766 22153697 15358760 17448444 15486308 18413311 20855588 16697011
SREBF1 LDLR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12180145 8402897 9651391 22153697 7597088 14998783 8636148 16153721 10224053
PCSK9 LDLR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 22081141 29209441 17435765 25613181 23085658 18753623 18250299
NR0B2 HNF4A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11535594 12716764 24318876 14672953 11679424 21725089 12601360 10594021 16527247
HNF4A PCK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 11557972 7831301 16308421 12840167 7935427 14722127 7819133 19720831 20577053 19651778
HNF4A NPC1L1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21123766 20953676 18080173 20460578
HNF4A CYP8B1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11535594 15539409 12069850 15933209 16264197 15322103 15550563
NR0B2 HNF4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 11535594 23331499 15604093 21071413 20516075 16488887 16455805 14672953 10594021
NR5A2 NR0B2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20375098 11705994 10409629 24498423 14627819 17204240 11518759 20460755
NR0B2 NR5A2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 23331499 14963109 21262773 11030331 15723037 20516075 21566081 22504882 12198243 11668176 20375098
NR1H4 NR0B2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 15817812 11705994 15692145 18842595 22345554 23546875 11030332 20185821 24498423 22683342 23607861 11518759
NR1H4 SREBF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 19028791 17660268 15146238 20699418 20699090 15973435 19496086
NFYA SREBF2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 12177166 18559965 9748295 18654640 8798690 20450493
NFYA SREBF1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 12177166 18559965 9748295 18654640 8798690 20450493
NFYA FDPS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8798690 20450493 7665553
SREBF2 HMGCR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 19288057 21944868 20936497 17448444 31848472 18413311
INSIG1 SCAP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 12202038 12482938 23564452 12842885 32111832 26555173 32432943
SCAP MBTPS1 â—¼   CLEAVAGE ✅ 6.0 1.0 Reactome 10644685 8156598 8674110 10428864 17449569 9488713
NR0B2 PCK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 15358835 20688914 18505831 18459945 19720831 17094771 22977252 12324453
NR0B2 CYP8B1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11535594 12525500 21566081 15581596 18323469
SREBF2 NFYC â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 12177166 18559965 9748295 18654640 8798690 20450493
SREBF1 NFYC â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 12177166 18559965 9748295 18654640 8798690 20450493
SREBF2 ABCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15922656 15358760 17526932 16901265
SREBF1 ACLY â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10777536 11994399 10801800
SREBF2 PCSK9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21123766 22288532 17448444 17921436
SREBF1 PCSK9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16407292 17921436
SREBF1 UCP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12205102 19082571 16153721 15677507
SREBF2 PON1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20728021
SREBF1 FASN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 10585876 16601238 20373869 11855808 20067991 18413311 12897158 11110846 17449569 18226595 16834571 15220339 17956315 12177166 19244231 17313375 16308421 23300015 11287605 17197698 11082286 11790787 12440974 10520861 17531980 18420801 18774944 11443121 16891625 20130133 20371699 18682402 22279139 18281474 21447637 11530940 22331133
SREBF1 SREBF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14702347 16282353 9786926 11278785
MBTPS2 SREBF1 â—¼   CLEAVAGE ✅ 4.0 1.0 Reactome 8674110 8156598 9659902 10805775
SREBF1 MBTPS1 â—¼   CLEAVAGE ✅ 6.0 1.0 Reactome 10644685 8156598 8674110 10428864 17449569 9488713
SREBF2 NPC1L1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 20460578 21123766 20953676 18080173 21527728
SREBF2 SQLE â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17027328 31848472 12083769
MBTPS2 SREBF2 â—¼   CLEAVAGE ✅ 4.0 1.0 Reactome 8674110 8156598 9659902 10805775
SREBF2 MBTPS1 â—¼   CLEAVAGE ✅ 6.0 1.0 Reactome 10644685 8156598 8674110 10428864 17449569 9488713
SPTBN1 GOLGB1 â—¼   PHYSICAL_INTERACTION 13.0 1.0 Reactome 29025582 28028030 24854988 28751768 19345670 17268528 23168613 27795560 30559310 31066629 17764812 16761019 21705501