Protein list:

Seperate proteins by space | Example

Select nodes using shift click or drag to add to this list
Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

Note this may take some time with > 30 proteins
Filter Graph:

0.5
Layout:
  🔂

Click a node or edge for more data...
Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
TP53 PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7915517
MYC ARF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219602 17289033
ARF1 GBF1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8810314 9614177
CDK2 HACD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0205180 30300385
SRC PXN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15574420 14665621
KRT8 ARFGEF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
STAT1 ARNT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19646959
ATXN10 MYC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
AURKA CDK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1001737 24358021
AURKA TP53 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 14702041 19121998
BAG2 CCAR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
ITGB3 BCAR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16581250 8649368
EGR1 BCAR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22431919
TP53 CCAR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20160719 20074560
CDH1 MMP9 â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 17332331 17354228
CDK2 MCM7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10523313 10373557
STAT3 CXCL12 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25453873 28072604
GEMIN4 DDX20 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10725331 5212337
TP53 EGR1 â—¼   COLOCALIZATION 2.0 0.8 intact 5216887 14744935
STAT3 EGR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17129668
EGR1 PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12384981
FOS EZR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19164283
FOS TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11350971 10984493
FOS MAPK3 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7588633 12134156
FOS MAPK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7588633 12134156
FOS NFKB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20188076
FOS SMAD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11854297
FOS RHOA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10085083 15068801
SRC FOS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17160021 22105363
MYC GEMIN4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17353931 17093053
ITGB1 JAM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12070135 17525755
PTP4A3 ITGB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19930715 16472776
TP53 KRT8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8615594
TP53 KRT8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
SRC MAPK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16580177 9924018
MAPK1 XPO5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 27846390
SRC MAPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16580177 9924018
TP53 MAPK3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21187340 16050810
MAPK3 XPO5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 27846390
TP53 MCM7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15899946
MMP2 MMP14 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8314771 8530478
NFKB1 MMP14 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19303700 21627988
MMP2 MMP14 â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 8314771 8530478
TIMP2 MMP14 â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 8314771 8530478
TP53 MMP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
MYC MSH2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12808131 11983916
TP53 MSH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12209975
STAT1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10637230
STAT3 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22943793 15810077
MYC MYO1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17353931 17093053
MYC TFRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10737792
PDCD6IP SRC â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5217348 15557335
PIK3R3 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 32606738
POLD1 SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
TP53 POLD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11375983
PTEN RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 10753747
SNAI1 PTP4A3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21811102 17545014
SRC RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10592173 23027962
XPO5 SMAD4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD4 SNAI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18618014 18832382
SSR4 SSR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17380188 5219807
SSR4 SSR3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 28218252 11964406
TYK2 STAT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15261459 23124025
CDK2 MCM3 â—¼   PHOSPHORYLATION ✅ + 0.8 0.8 Signor 21965652
CDH1 SRC â—¼   PHYSICAL_INTERACTION 816.0 0.81 STRING 36370105
ITGA5 ITGB3 â—¼   PHYSICAL_INTERACTION 818.0 0.81 STRING 36370105
CDK2 MYH9 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26496610 21319273
NFKB1 DPM1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25609649 27609421
RHOA IPO4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31871319 31980649
MCM3 MYC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 29467282 17353931
MYC MDN1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 29467282 17353931
MYC TTC27 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17314511 29467282
MYC PCBP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17314511 29467282
MYC PSMD3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17314511 29467282
SEC63 UFL1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 32807901 33957083
SSR3 SSR4 â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
EGR1 TP53 â—¼   PHYSICAL_INTERACTION 828.0 0.82 STRING 36370105
MMP10 TIMP2 â—¼   PHYSICAL_INTERACTION 829.0 0.82 STRING 36370105
MYC DPM1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 21150319 17314511 29467282
TTI1 MTOR â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 22544753 20810650 20427287
RHOC RHOA â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 31871319 31980649
MTOR STAT3 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
NUP188 NUP93 â—¼   CORRELATES + 0.83 0.83 CCLE 31978347
AIFM1 CLPX â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 29568061 34079125
STAT1 MTOR â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 19553685 25241761 12807916
SMAD4 SKP2 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 15314162 16865698
STAT1 SRC â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 14978237 10358079 9344858 16189514
CDK2 MCM3 â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
CDH1 SKP2 â—¼   PHYSICAL_INTERACTION 849.0 0.84 STRING 36370105
USO1 GBF1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 12634853 31519766
STAT3 STAT1 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 6730629 8662591
PTEN TP53 â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
MCM3 CDK2 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 16189514 21965652 15232106
CDK2 TP53 â—¼   PHOSPHORYLATION ✅ + 0.86 0.86 Signor 24173284
MLF2 MMS19 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 22678362 17353931
MYC MYO1B â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 29467282 17353931
MYC OPA1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 21150319 17353931
MYC PDS5A â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 29467282 17353931
MYC XPO5 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 17314511 17353931
NUBP2 RHOA â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 22939629 31980649
RAC1 STAT3 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 11021801 16189514
MTOR TTI1 â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
CNNM3 PTP4A3 â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
ITGB1 PXN â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
AURKA NFKB1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 27609421 25609649 26186194 28514442
MYC DDX20 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 17314511 29467282 17353931
STRAP DDX20 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 24981860 29395067 26496610 28514442
DDX20 GEMIN4 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
DDX20 USO1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 29395067
FZR1 SKP2 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
MYC IPO4 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 17314511 29467282 17353931
MYC MMS19 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 17314511 29467282 17353931
MYC SMC2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 17314511 29467282 17353931
MYC SKP2 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
AURKA TP53 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
DDX20 STRAP â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
MAPK1 TP53 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
RAB3GAP1 RAB3GAP2 â—¼   CORRELATES + 0.87 0.87 CCLE 31978347
MLF2 AIFM1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 29568061 17353931
CDKN2A MYC â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
STAT1 STAT3 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
SRC STAT3 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
NCAPG SMC2 â—¼   CORRELATES + 0.88 0.88 CCLE 31978347
MMP14 TIMP2 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
ITGA1 ITGB1 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
MAPK1 MAPK3 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
MAPK1 STAT3 â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
MLF2 BAG2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 25036637 17353931
MYC FANCI â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 30415952 29467282 17353931
MYC NUP93 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 21150319 29467282 17353931
CDKN2A TP53 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
PCNA CDK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10930425
PTP4A3 ARF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 ACSN 22595524 23691193 24376839
PTP4A3 ARF1 â—¼   SHARES_COMPLEX 3.0 0.9 ACSN 22595524 23691193 24376839
PTP4A3 ARF1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 22595524 23691193 24376839
ARF1 TFRC â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 22595524 23691193 24376839
ARF1 ITGA5 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 22595524 23691193 24376839
MYC ARF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
PTP4A3 GGA1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 ACSN 22595524 23691193 24376839
PTP4A3 GGA1 â—¼   SHARES_COMPLEX 3.0 0.9 ACSN 22595524 23691193 24376839
PTP4A3 GGA1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 22595524 23691193 24376839
MYC TUBG2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
TP53 AIFM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23506862 16729031
EGR1 ATP2A2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10625299 8977381 18612190
SMAD4 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 22775504 17452626 24625091
TP53 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15383401 20332115 21478913
SKP2 CDK2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 20160477 23455922 26496610 22770219 23602568 7553852 9636170 9858587 15355997 25852190 10386600 16979657 28514442 16189514 18604603 33422522 19686743 19270695 26186194 10559858
DAPK3 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17339337
EGR1 NFKB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9053449 10671503
RHOA EZR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 35267019 15659383
PTP4A3 EZR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18078820
GTF2I MYC â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 17314511 30415952 8377829 29467282
MAPK1 GTF2I â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10648599
PTP4A3 ITGA5 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 22595524 23691193 24376839
SRC ITGB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10592173 11723131 11259684
PTP4A3 JAM2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 ACSN 23691193 24376839 27588115
PTP4A3 KRT8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19115206
MAPK1 RAC1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 17202194 15657136 21419341
MEF2C MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9069290 17210568 9988769
RHOA MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10617617 9854026 12810709
MAPK1 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18378670 7569900 14963018
MAPK3 RAC1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 17202194 15657136 21419341
RHOA MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10617617 9854026 12810709
MYC MCM7 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 30415952 17314511 29467282 17353931
MYC MCM7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
TIMP2 MMP2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 9933646 9410885 9182583 12374789 28514442 12032297 10991943
SNAI1 MMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12632084 16391805 22943878
NFKB1 MMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19303700 20352621 17498959
MYC MSH2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 29467282 30415952 28205554 17314511 28628118 12584560
TP53 MSH2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11350971 8630028
MYC RHOA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22159222 20383141 22235332
NFKB1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 2191300 18490439 19219071
NFKB1 STAT3 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 25241761 12057007 16713569
SRC PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25814554 22402981
TP53 PTP4A2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16980608
PTP4A3 ULBP2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 23691193 24376839 25687758
PTP4A3 TFRC â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 22595524 23691193 24376839
STAT1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24655378 14602726
STAT3 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16107692 23874455 20043094
TP53 TMEM33 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16980608
GGA1 RABEP1 â—¼   PHYSICAL_INTERACTION 902.0 0.9 STRING 36370105
MCM3 MCM7 â—¼   CORRELATES + 0.9 0.9 CCLE 31978347
BCAR1 SRC â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
MSH2 PCNA â—¼   PHYSICAL_INTERACTION 909.0 0.9 STRING 36370105
CDK2 SKP2 â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
PXN BCAR1 â—¼   UP_REGULATES ✅ + 0.91 0.91 Signor 27447856
CDK2 FZR1 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
SSR1 SSR3 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
NUP188 NUP93 â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
CNNM3 PTP4A2 â—¼   PHYSICAL_INTERACTION 939.0 0.93 STRING 36370105
PCNA MSH2 â—¼   PHYSICAL_INTERACTION 0.94 0.94 HIPPIE 8858149 16189514 12171929 15225546
PCNA CDK2 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 28514442 33961781 26496610 7903056 9545286 26186194 12361598 21319273 10930425 29510343
GGA1 ARF1 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 21198641 15143060 10747089 11950392 12636914
HIST1H3J IPO4 â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
SRC BCAR1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 10085298 21034468 10487518 11514617 10542110 15020686 16849545 12397603 12615911 17038317 10739664 12972425 17129785
MMP2 TIMP2 â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
SEC61A1 SEC63 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
RPTOR MTOR â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 24036451
MTOR RPTOR â—¼   COLOCALIZATION ✅ 0.98 0.98 mint 21045808 8088164
ITGA5 ITGB1 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
MTOR RPTOR â—¼   PHOSPHORYLATION ✅ + 0.98 0.98 Signor 19346248
CDK2 PCNA â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
NCAPG SMC2 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
MLST8 MTOR â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PSMC5 PSMD3 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
FNTA FNTB â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
MCM3 MCM7 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
PCNA FANCI â—¼   PHYSICAL_INTERACTION 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
PCNA POLD1 â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611
PCNA POLD1 â—¼   SHARES_COMPLEX 9.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611
PCNA FANCI â—¼   SHARES_COMPLEX 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
PCNA POLD1 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
TP53 PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 10321841 7915517 15358233 12217864 10516009 1705714 8570655 16980608 9707425 15950182 19789303 11313928 1356162 12384701 9858527 12947108 23390122 8524244 9651310 1352831 7909518 11032828 10910968 12485898 10618724
MYC PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 7597041 18358094 22911891 18809243 1280813111085504 11085504
PXN BCAR1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 ACSN 12473693 14749719 15094799 15308668 15688067 16000375 18287025 18829532 18835194 22043013 29021139 9819392
PXN BCAR1 â—¼   SHARES_COMPLEX 12.0 1.0 ACSN 12473693 14749719 15094799 15308668 15688067 16000375 18287025 18829532 18835194 22043013 29021139 9819392
VEGFR2 PXN â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 16472776 16951216 17192274 19930715 22131018 23589069 24403062 27452906 29556339
PTP4A3 PXN â—¼   DOWN_REGULATES ✅ - 4.0 1.0 ACSN 17409395 23691193 24376839 27588115
MAPK1 PXN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10753946 15494312 11784715 14636584
SRC PXN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 46.0 1.0 Omnipath 9636140 28214467 15572663 15592455 16713569 14665621 25795725 7537852 7615549 25405379 11774284 26700725 25182764 15107421 7534286 2472406 12408869 11695992 17570479 10823820 7525621 20103658 16254239 15817476 23109003 27447856 28626446 16094384 18363833 19543320 24364863 28376152 19138410 25323586 27941878 23457577 10085298 22638989 27669437 15212693
PXN BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11313252 9418872 11577104 9759889 8810278
PTP4A3 VEGFR2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 23691193 24376839 24403062 24686170
VEGFR2 SRC â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 16472776 16951216 17192274 19930715 22131018 23589069 24403062 27452906 29556339
MYC GCN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20936779 17353931 17314511 17093053
ARNT MMP14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 7539918 15592504 1823643 16716598 12829734 9159130 13130303 9746763 12080085 11566883 10403805 8943284 15451019 9278421 16887934
MYC AURKA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20890087 20519624 14744757 20682043
AURKA TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 50.0 1.0 Omnipath 24173284 22864622 25217103 24089029 16713569 19413330 25848977 17999753 23565200 25333414 23201157 16552184 10884347 1956339 26186194 29455673 15469940 15749021 18974145 21502403 17287340 28043820 22396649 92065884 12198151 27933271 22852086 12064478 30266789 25398437 17259342 22350019 25634113 14702041
SRC BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 62.0 1.0 Omnipath 19901323 24962474 11514617 8670206 15316024 20927395 8070403 17389395 12480533 22710723 30422386 25976166 17570479 21963850 12972425 20103658 17129785 10487518 15817476 21301050 10739664 17038317 21765460 17016520 12397603 15212693 15020686 10542110 23457577 10085298 12615911 15272013 21034468 11604500
PTP4A3 CCL26 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 23691193 24376839 24686170 29051319
MYC CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9632747 19176757 23364919 10523846
SNAI1 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 71.0 1.0 Omnipath 16502042 16424022 18347060 19874710 23054398 11912130 12668723 21081648 24168186 20455091 16617148 19635798 24424621 15300012 22775504 12508111 25025961 23637992 20576520 24228088 18701475 20562920 22562246 23424071 21685935 15026811 24504364 18801366 19055748 18321996 17060462 23295740 22128911 23752226 24293287 16273209 19893985 18385519 23671646 17724139 24305977 20801642 10655587 15492833 19789323 21846773 19784072 17082242 17671186 22911555 14673164 16804902 17490644 23658826 18519590 12579345 22158034 17655524 24095903 18565826 20053763 15311212 15448698 19179606 12161443 22614005 18773488 21796367 24448241 16322400
SNAI1 CDH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 15169839 17615296 22796940 20818389 21685935 20519943 12508111 11309385 17018611 22514743 19597490 14673164
PTP4A3 CDH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 15169839 17615296 22796940 20818389 21685935 20519943 12508111 24376839 11309385 23691193 19597490 14673164
CDH1 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 17496910 19029934 22370635 16099633 23343194 19734908 10744074 16039586 22203675 19171760 22007144 19619488 17143292
MYC CDK2 â—¼   PHYSICAL_INTERACTION 34.0 1.0 ACSN 11274345 11283614 12545156 14536078 15147722 15155580 15279786 17055429 17303408 17550342 17558397 17660363 17873522 18590585 18636226 19887899 20027199 20237412 20551172 20581311 20713526 20818389 21406394 21733352 2191300 21919891 22067385 23140366 23869868 24954210 25002027 28536364 7575488 9618481
MYC CDK2 â—¼   SHARES_COMPLEX 34.0 1.0 ACSN 11274345 11283614 12545156 14536078 15147722 15155580 15279786 17055429 17303408 17550342 17558397 17660363 17873522 18590585 18636226 19887899 20027199 20237412 20551172 20581311 20713526 20818389 21406394 21733352 2191300 21919891 22067385 23140366 23869868 24954210 25002027 28536364 7575488 9618481
CDK2 MCM7 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 14536078 15147722 15175241 15279786 15677884 16581787 17038621 17102137 17116885 17296725 17303408 17582221 17660363 17713585 18590585 18636226 19793801 7575488
CDK2 FZR1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 10323868 10375532 16582612 12730199
CDK2 MCM3 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 14536078 15147722 15175241 15279786 15677884 16581787 17038621 17102137 17116885 17296725 17303408 17582221 17660363 17713585 18590585 18636226 19793801 7575488
CDK2 CDKN2A â—¼   DOWN_REGULATES ✅ - 32.0 1.0 ACSN 11274345 11283614 12545156 14536078 15147722 15155580 15279786 17055429 17303408 17550342 17558397 17660363 17873522 18590585 18636226 20027199 20237412 20551172 20581311 20713526 20818389 21406394 21733352 2191300 21919891 22067385 23140366 23869868 25002027 28536364 7575488 9618481
MAPK1 CDK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10962581 12359725
CDK2 FZR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 11598127 15577895 9736735 12560341 15558010 20068231 10548110 16123593 15840442 18669648
CDK2 MCM3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 7575488 18590585 17296725 17303408 21965652 30062004 17102137 17116885 19793801 17582221 15232106 16189514 17660363 15279786
CDK2 SKP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 7553852 20160477 23602568 25271736 18239684 28446188 23226679 10386600 19270695 26496610 16189514 25852190 26186194 25788262 9858587 22770219 15355997 10559858 23807222 22311674 16979657 9636170 19686743 19270694 18604603 23455922
CDK2 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 8386367 27653698 17081983 19966300 18669648 29896817 17570479 20713526 17558397 15103331 22348395 20445224
CDK2 PRKAR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 15572359 19007248 17081983 20166139 18767875 19562805 19413330 19415658 20068231 18452278 16582606 25605337 18669648 18691976 17287340 19651622 20058876 19664994 18707149 18212344
CDK2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 24173284 9315650 19413330 19664995 16083285 1088347 16552184 10884347 17570479 10747897 25241761 7624134 11687964 17287340 92065884 12064478 19556892 14640983 10348343 14702041
CDK2 PGR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 43.0 1.0 Omnipath 8662865 15572662 17717077 26577046 7476977 20116396 24291072 10628747 24333793 11509655 21945472 21447625 29301281 27852068 25252652 22809143 18202149 18088087 15798179 19118566 9171245 10655479 11110801 15601848 28412963 19706513 22697792 12529413 15212693 19904813 24302725
MYC CDKN2A â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11274345 11283613 11283614 11704864 15199070 17055429 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 25002027 28536364 9694806
MYC CDKN2A â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 11274345 11283613 11283614 11704864 15199070 17055429 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 25002027 28536364 9694806
MYC CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 15361884 11593429 11507042 20023701 23342141 16537449 23277542 10914736 9212167 12835716 24177224 11062467 15199070 18762810 19786833 20551174 11360201 23722468
TP53 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 16103197 22467867 18555006 8631601 11402335 19649205 22020338 21164364 17265068 16764954 15775976 22056554 18275833 21483786 10348346 19216023 12384561 12091906 19901969 11360201 15205322 11818069 21892281 10980602 11739748 11559812 24672805 10097151 17907153 19244234 15361884 10652576 9436028 21447739 20569441 21555589 21637567 10816133 9774662 19240179
MYC CDKN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 15361884 9308237 10373560 17936558 12209154 12738781 17873522 11283613 21406394 9312026 15095404 17558397 20551172 19901969 19815509 10504341
CDKN2A TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 15856024 15989956 9724636 19960022 12740913 17158541 12640129 19590512
CXCL12 RHOA â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 15261139 15882617 17035340 20535745 20644254 21521526 22025564 23034983 23402812 23567181 24277834
PTP4A3 EGR1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 19945467 23691193 24376839 24686170
EGR1 PTEN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 17330857 17479230 20514024 12917634 17516844 15231710 18062928 18324520 11781575 20862322 16138117 21297666 20959484 16424010 15517593
EGR1 MMP14 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10428849 19326468 17158885 14979875 12093818 18277865 18568943 12118097
EGR1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9242687 17822668 15958557 12755686 16990849
EGR1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15225550 14744935 11251186 16713569 12384981
PTP4A3 EZR â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 18078820 21806020 22137788 23691193 24376839
SRC EZR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 16438931 22397367 14504278 25231728 21818323 24339867 15623525 18701134 22262457 24385580 18078820 28306714 15647376
FNTB FNTA â—¼   PHYSICAL_INTERACTION 1.0 1.0 HIPPIE 33961781 15248757 12036349 32296183 11687658 24981860 15170324 15451670 26186194 12825937 28514442 16189514
PTP4A3 FOS â—¼   DOWN_REGULATES ✅ - 5.0 1.0 ACSN 16540666 23418787 23691193 24376839 24686170
STAT1 FOS â—¼   UP_REGULATES ✅ + 20.0 1.0 ACSN 11134049 11830590 12193701 12223527 12796776 12811837 12967644 14607900 14764699 15814715 17016554 17513775 17559085 17689680 18272812 19833085 21263073 21930765 25960930 8683106
STAT3 FOS â—¼   UP_REGULATES ✅ + 38.0 1.0 ACSN 10347215 11528470 12223527 13130303 14607900 14670306 15218058 15356132 15573129 15810077 16418395 16716598 16831886 17403902 18297062 18776941 18832382 19380816 19412634 20093776 20237412 20406969 20581311 21317430 21840487 21883379 22006115 22943793 22945800 23124025 23454751 23953057 24857661 27216177 28186502 7543512 7768934 9278421
STAT3 FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17204573 14737107 12640143 12600988 11685114 8071311 15040450 16293640
GTF2I FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9584171 12082086 11934902 16611241 10082538 19097122 11313464
TP53 FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 8604347 17174366 8668332 1946467 10082525 10214938 1508692 8649776 10529369 12173040
STAT1 FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 8874187 7510676 8830676 12600988 7507205 8770944 17558387
FOS MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 16554298 11774399 21238464 18809380 23508111 21474819 15319566 10935492 21940623 24173318 16882662 21047770 9136992 23955082 23176293 12032150
FOS PGR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16293641 14684847 12446585
FOS MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11939505 2463066 1696944 8276360 9950153 2139817 2498162 21607323 20410304 8490168 7654239
SMAD4 FOS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 9732876 10942775
MAPK1 FOS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 49.0 1.0 Omnipath 12134156 20506250 15547943 8248197 7816602 15084594 12697810 8226933 20068231 18452278 12738796 16393692 17255949 17439715 15187187 19541618 23109003 19565474 17722974 17052211 7588633 8545107 16055710 8388392 18039929 12972619 18775330 21098038 9604935 11274345
MAPK3 FOS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 17018293 12134156 20506250 15547943 7816602 15084594 12697810 8226933 12738796 16393692 17255949 17439715 15187187 19541618 23109003 19565474 17722974 17052211 7588633 8545107 16055710 8388392 18039929 12972619 18775330 26725323 21098038 9604935 11274345
MAPK3 GTF2I â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10648599
SRC GTF2I â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 15664986 15212693 20568114 9012831 11934902 16314517 11373296 17570479 16738337 9837922 11313464
ITGB1 ITGA5 â—¼   PHYSICAL_INTERACTION 29.0 1.0 ACSN 10461188 10545505 10559936 10613909 11340065 11413130 11950587 12731048 15866889 16076871 16919435 17522712 18037882 19161977 19339212 19454690 19487819 20644254 20814939 22067905 22154077 22470492 24202395 7529872 7657702 9003039 9456329 9763606 9973479
PTP4A3 ITGB1 â—¼   PHYSICAL_INTERACTION 15.0 1.0 ACSN 16472776 19161977 19454690 19487819 19930715 22470492 23092334 23691193 24376839 27588115 28284838 9003039 9456329 9763606 9973479
PTP4A3 ITGB1 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 16472776 19161977 19454690 19487819 19930715 22470492 23092334 23691193 24376839 27588115 28284838 9003039 9456329 9763606 9973479
MYC ITGB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11381265 16878156 12695333
PTP4A3 ITGB3 â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 10048576 16617148 16831886 17563753 17671186 18832382 20731704 21317430 22406545 23691193 24376839 7512751 7528107
SRC ITGB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 10330414 17473008 8631894 18156175 25694433 18840695 18364349 18398066 10592173 16935858 21956114 17353363 18088087 12359711 15212693 14996908 15695822 15699036 11723131 20702409
PTP4A3 KRT8 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 19115206 23691193 24376839 24686170
MYC MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22789855 21933022 16596619 23617883 8013639 20144848
MAPK1 RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 21071439 19339977 19864431 21325048 22493283
MAPK1 PGR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 8702648 17173941 18202149 10628747 15798179 17717077 12529413 15212693 10655479 11110801
MAPK1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 10551811 17081983 8386367 17251036 91332050 17570479 1748630 7957875 27167001 15212693 1651323 15210690
MAPK1 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12975377 23602568 16424009 19058874 23397142 21707490
MAPK1 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12801888
MAPK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 14965474 9765199 15116093 21675959 23443559 10781582 25241761 10446957 10958792 11409876 11709713 21147777 10673501 11551930 15867353 11875057 12091386
MAPK1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 59.0 1.0 Omnipath 18448488 19413330 11335711 9343414 15465816 25584415 12576423 11350938 20068231 12681450 12763138 9872331 11780390 18491316 18669648 11404481 10521505 18691976 20058876 15979846 14551213 10446219
MAPK3 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 10781582 11239457 10958792 28937686 9467949 10348343 24194938 9739174 16713569 12955074 10747897 17237827 25767119 18523266 12393879
MAPK3 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 18463697 9155018 21071413 32482868 18988627 15210690
MAPK3 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 28115363 12801888
MAPK3 RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21757713 21071439 19339977 19864431
MAPK3 PGR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 12529413 10655479 10628747
MAPK3 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 73.0 1.0 Omnipath 18448488 19413330 11335711 9343414 23331499 15465816 25584415 12576423 11350938 20068231 12681450 10417333 12763138 9872331 18988627 11780390 18491316 18669648 11404481 10521505 18691976 19723038 20058876 14551213 10446219
MCM7 MCM3 â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 7575488
MCM7 MCM3 â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 7575488
MCOLN1 MCOLN3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23469151 19522758 16606612 20736310 19885840 19557826
MEF2C PTP4A3 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 18471976 20609352 21053359 21084277 21811102 22073279 22970020 23178297 24403062 25139404 27222233 27526109
MTOR MLST8 â—¼   PHYSICAL_INTERACTION 88.0 1.0 ACSN 10702316 10722653 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16556040 16678438 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17461779 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20027184 20138985 20338997 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21533173 21621563 21708191 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025 9069260
RAC1 MLST8 â—¼   PHYSICAL_INTERACTION 56.0 1.0 ACSN 10702316 10722653 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16556040 16678438 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18481918 18492954 18570873 18925875 19022819 19027299 19143635 19143636 19151919 19225151 19244117 19446321 19568798 19706736 19720745 19864431 20027184 20138985 20338997 20547845 20805416 21157483 21474067 21533173 21621563 21708191 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MLST8 RPTOR â—¼   PHYSICAL_INTERACTION 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
MTOR MLST8 â—¼   SHARES_COMPLEX 88.0 1.0 ACSN 10702316 10722653 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16556040 16678438 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17461779 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20027184 20138985 20338997 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21533173 21621563 21708191 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025 9069260
RAC1 MLST8 â—¼   SHARES_COMPLEX 56.0 1.0 ACSN 10702316 10722653 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16556040 16678438 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18481918 18492954 18570873 18925875 19022819 19027299 19143635 19143636 19151919 19225151 19244117 19446321 19568798 19706736 19720745 19864431 20027184 20138985 20338997 20547845 20805416 21157483 21474067 21533173 21621563 21708191 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MLST8 RPTOR â—¼   SHARES_COMPLEX 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
PTP4A3 MLST8 â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 17409395 19440036 19945467 20609352 21084277 23691193 24030100 24376839 24696260 25136802 26597054 27328425 27572739
RAC1 MLST8 â—¼   ENZYMATIC_REACTION ✅ 56.0 1.0 ACSN 10702316 10722653 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16556040 16678438 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18481918 18492954 18570873 18925875 19022819 19027299 19143635 19143636 19151919 19225151 19244117 19446321 19568798 19706736 19720745 19864431 20027184 20138985 20338997 20547845 20805416 21157483 21474067 21533173 21621563 21708191 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MTOR MLST8 â—¼   ENZYMATIC_REACTION ✅ 88.0 1.0 ACSN 10702316 10722653 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16556040 16678438 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17461779 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20027184 20138985 20338997 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21533173 21621563 21708191 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025 9069260
MLST8 MYC â—¼   ENZYMATIC_REACTION ✅ 23.0 1.0 ACSN 12150925 12408816 12906785 15755954 16469695 17604271 17680028 18372248 18492954 19022819 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MLST8 MMP9 â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 12150925 12408816 12906785 15755954 16469695 17680028 18492954 19022819 19568798 19864431 19930715 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26597054 27328425 27510662 27572739 28216025
MLST8 MMP2 â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 12150925 12408816 12906785 15755954 16469695 17680028 18492954 19022819 19568798 19864431 19930715 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26597054 27328425 27510662 27572739 28216025
MLST8 RPTOR â—¼   ENZYMATIC_REACTION ✅ 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
RAC1 MLST8 â—¼   DOWN_REGULATES ✅ - 56.0 1.0 ACSN 10702316 10722653 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16556040 16678438 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18481918 18492954 18570873 18925875 19022819 19027299 19143635 19143636 19151919 19225151 19244117 19446321 19568798 19706736 19720745 19864431 20027184 20138985 20338997 20547845 20805416 21157483 21474067 21533173 21621563 21708191 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MTOR MLST8 â—¼   LOCALISATION ✅ 88.0 1.0 ACSN 10702316 10722653 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16556040 16678438 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17461779 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20027184 20138985 20338997 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21533173 21621563 21708191 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025 9069260
MLST8 RPTOR â—¼   LOCALISATION ✅ 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
PTP4A3 MMP10 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 23691193 24376839 24686170 27452906
PTP4A3 MMP14 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 23691193 24376839 27096756 27588115
MMP14 MMP2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 11112697 18037882 18633355 22880008 23737743
MMP14 MMP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8663332 14583471 24376839 23691193 11857380
MTOR MMP2 â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 12150925 12408816 12906785 15755954 16469695 17680028 18492954 19022819 19568798 19864431 19930715 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26597054 27328425 27510662 27572739 28216025
RPTOR MMP2 â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 12150925 12408816 12906785 15755954 16469695 17680028 18492954 19022819 19568798 19864431 19930715 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26597054 27328425 27510662 27572739 28216025
PTP4A3 MMP2 â—¼   UP_REGULATES ✅ + 13.0 1.0 ACSN 10048576 16617148 16831886 17563753 17671186 18832382 20731704 21317430 22406545 23691193 24376839 7512751 7528107
TP53 MMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 18980971 22451655 23048035 10029407 9343394 19853299 11792711 19939245 17088079 17258390
TIMP2 MMP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 17145710 9182583 19010413 12023034 9410885 12475252 21839835 9933646 12032297 12374789 10991943
STAT3 MMP9 â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
MTOR MMP9 â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 12150925 12408816 12906785 15755954 16469695 17680028 18492954 19022819 19568798 19864431 19930715 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26597054 27328425 27510662 27572739 28216025
RPTOR MMP9 â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 12150925 12408816 12906785 15755954 16469695 17680028 18492954 19022819 19568798 19864431 19930715 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26597054 27328425 27510662 27572739 28216025
PTP4A3 MMP9 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 23691193 24376839 24686170 27328425 27510662 27572739
MYC MMP9 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10432118 11274345 11283614 11875494 16327802 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21093321 21372296 21406394 21765015 2191300 22067385 22461508 23124025 23390297 25002027
SNAI1 MMP9 â—¼   UP_REGULATES ✅ + 66.0 1.0 ACSN 10048576 11283614 11708773 12490555 12545156 12668723 14623871 14673164 15111329 15151915 15155580 15181457 15448698 15459715 16001073 16079281 16232121 16510505 16556862 16617148 16716598 16831886 17018611 17055429 17093497 17403902 17490644 17537911 17550342 17563753 17615296 17671186 18172008 18297062 18832382 19208835 19412634 19564415 19597490 19935649 20027199 20702634 20706219 20713526 20731704 21041997 21051859 21159887 21199805 21317430 21577210 21685935 21883379 2191300 22006115 22286765 22406545 22439866 22514743 22796940 22945800 23140366 23869868 8844971 9157999 9618481
TP53 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17311279 15899818 17077165 18635530
STAT1 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 15247301 18028425 19965686 10817568 19616522
NFKB1 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 18298869 12105194 11376631 14600595 17673602 17922642 15605368 14755547 20332461 18357389 17186550 11060311 18566231 9679762 16687076 17121934 18843978 21963718 18056465 20103608 17174275 15536164 19303700 17158602 7860222 19539355 9500201 19783786 18567920 15175338 17498959 10359016 18801463 19454280 19662350 12193473 16014933
RAC1 MTOR â—¼   PHYSICAL_INTERACTION 56.0 1.0 ACSN 10702316 10722653 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16556040 16678438 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18481918 18492954 18570873 18925875 19022819 19027299 19143635 19143636 19151919 19225151 19244117 19446321 19568798 19706736 19720745 19864431 20027184 20138985 20338997 20547845 20805416 21157483 21474067 21533173 21621563 21708191 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MTOR RPTOR â—¼   PHYSICAL_INTERACTION 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
RAC1 MTOR â—¼   SHARES_COMPLEX 56.0 1.0 ACSN 10702316 10722653 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16556040 16678438 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18481918 18492954 18570873 18925875 19022819 19027299 19143635 19143636 19151919 19225151 19244117 19446321 19568798 19706736 19720745 19864431 20027184 20138985 20338997 20547845 20805416 21157483 21474067 21533173 21621563 21708191 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MTOR RPTOR â—¼   SHARES_COMPLEX 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
RAC1 MTOR â—¼   ENZYMATIC_REACTION ✅ 56.0 1.0 ACSN 10702316 10722653 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16556040 16678438 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18481918 18492954 18570873 18925875 19022819 19027299 19143635 19143636 19151919 19225151 19244117 19446321 19568798 19706736 19720745 19864431 20027184 20138985 20338997 20547845 20805416 21157483 21474067 21533173 21621563 21708191 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
PTP4A3 MTOR â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 17409395 19440036 19945467 20609352 21084277 23691193 24030100 24376839 24696260 25136802 26597054 27328425 27572739
MTOR RPTOR â—¼   ENZYMATIC_REACTION ✅ 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
MTOR MYC â—¼   ENZYMATIC_REACTION ✅ 23.0 1.0 ACSN 12150925 12408816 12906785 15755954 16469695 17604271 17680028 18372248 18492954 19022819 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
RAC1 MTOR â—¼   DOWN_REGULATES ✅ - 56.0 1.0 ACSN 10702316 10722653 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16556040 16678438 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18481918 18492954 18570873 18925875 19022819 19027299 19143635 19143636 19151919 19225151 19244117 19446321 19568798 19706736 19720745 19864431 20027184 20138985 20338997 20547845 20805416 21157483 21474067 21533173 21621563 21708191 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MTOR RPTOR â—¼   LOCALISATION ✅ 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
TTI1 MTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 20427287 20810650
RPTOR MTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 139.0 1.0 Omnipath 15268862 24403073 20427287 22258093 21321085 19446321 15467718 19875983 17461779 12665511 12719976 16631613 21045808 21177249 23911927 24337580 25446900 24516643 18614546 12718876 12747827 16603397 17043309 18519641 22544753 25007995 27043084 19145465 23953116 19619545 16919458 24375676 15459249 16837165 16847060 25332233 12150926 22424946 26348909 12150925 18955708 20381137 22356909 17386266 17565979 18030348 16354680 20169205 19114562 21071439 27329724 35561222 16798736 15809305 22493283 17277771 15661536 16962653 1683716516603397 17604271 18676370 16183647 18505677 23297343 23872070 24036451 15066126 18570873 21614075 18722121 12408816 17599906
MTOR STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 29228628 10660304 22408571 12796477 16740698 18691976 26573296 15522880 27384580 26775702 24423131 26241748 23055980
NFKB1 MYC â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 18490439 19219071 21725609 2191300 23178297 23572150
RPTOR MYC â—¼   ENZYMATIC_REACTION ✅ 23.0 1.0 ACSN 12150925 12408816 12906785 15755954 16469695 17604271 17680028 18372248 18492954 19022819 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
STAT3 MYC â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
MYC PTP4A3 â—¼   UP_REGULATES ✅ + 17.0 1.0 ACSN 11274345 11283613 11283614 11704864 17055429 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 25002027 28536364
PGR MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 8701093 9408078 22396492 9305935 22892083 10651641
NFKB1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 12894581 18184402 7869034 17673602 12783888 11114727 17944672 9596659 12504005 19469019 21790895 19766095 17018379 8289784 18566231 1515224
STAT3 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 19289167 17204573 18184402 22317895 20067773 15184887 15469392 10464281 9325164 20654581 21573184 17959148 22349830 9874564 20581311 19259613
SMAD4 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11689553 17132729
MYC SKP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 24259667 12963825 12769844 23792459 21245140 24177224 23277542
MYC PTEN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23135913 19578399 12695333
MYC TFRC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 3302722 12695333 14519204 16466700 20631077
MYC TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 10962037 10656696 8494784 10348347 19882681 16557594 19086036 15780936 14519204 16112647 11781835 7969121 11789587 9839551
SMARCB1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10319872 14559996 14964309 19234532
SKP2 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 17145710 24259667 12963825 12769844 17157259 23277542 20852628 16376880 35260179 26038816
RHOC MYH9 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 12185584 2966156 8702756 17151359 3839510
PTP4A3 NFKB1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 21725609 23178297 23572150 23691193 24376839
NFKB1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10348347 11032029 8051093 12145335 20097177
PCBP1 PTP4A3 â—¼   DOWN_REGULATES ✅ - 6.0 1.0 ACSN 20609352 21053359 21811102 22469786 25475733 27328425
SRC PDCD6IP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 15557335
RHOA PTEN â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10953004 11698448 11729192 11739775 11992112 12194823 12361600 12740575 12778124 14657501 14744429 15761148 15793569 17517963 18037882 18423981 20008297 20351293 20535745 21178402 21642958 21840487 22949611 24857661 24919149 26885855 27048821 27066895 7479854 9362522 9660866 9822605
PTP4A3 PTEN â—¼   DOWN_REGULATES ✅ - 4.0 1.0 ACSN 22677902 23691193 24376839 24686170
SNAI1 PTEN â—¼   DOWN_REGULATES ✅ - 66.0 1.0 ACSN 10048576 11283614 11708773 12490555 12545156 12668723 14623871 14673164 15111329 15151915 15155580 15181457 15448698 15459715 16001073 16079281 16232121 16510505 16556862 16617148 16716598 16831886 17018611 17055429 17093497 17403902 17490644 17537911 17550342 17563753 17615296 17671186 18172008 18297062 18832382 19208835 19412634 19564415 19597490 19935649 20027199 20702634 20706219 20713526 20731704 21041997 21051859 21159887 21199805 21317430 21577210 21685935 21883379 2191300 22006115 22286765 22406545 22439866 22514743 22796940 22945800 23140366 23869868 8844971 9157999 9618481
ZNF699 PTEN â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 22810004 23125220 24141770 23287862 18055759 22700976 20956939 21637289
TP53 PTEN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 22957312 15843377 12917634 21637289 17344317 12839924 11545734 18172008 19173293 20554748 19079342 14984207
TP53 PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 21336307 18431400 18339852 12620407 17409411 18172008 17823410 16713569 21518799 21483453
SRC PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 24830552 22891331 12869565 21532586
PTP4A3 STAT3 â—¼   ENZYMATIC_REACTION ✅ 47.0 1.0 ACSN 10347215 12223527 14607900 14670306 15218058 15356132 15573129 16418395 16540666 17192274 17409395 18268019 18471976 18776941 19380816 20093776 20237412 20406969 20581311 20609352 20681446 21053359 21084277 21811102 21840487 22073279 22677902 22825514 22970020 23124025 23178297 23454751 23691193 23953057 24030100 24376839 24403062 24857661 25139404 25687758 27036022 27216177 27222233 27452906 27526109 28186502 7543512
PTP4A3 SRC â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 16472776 16540666 17192274 17409395 18268019 19930715 20681446 22131018 22677902 22825514 23589069 23691193 24030100 24376839 24403062 25687758 27036022 27452906 29556339
PTP4A3 RHOC â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 16540666 17192274 17409395 18268019 20681446 22677902 22825514 23691193 24030100 24376839 25687758 27036022 27452906
PTP4A3 RAC1 â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 16540666 17192274 17409395 18268019 20681446 22677902 22825514 23691193 24030100 24376839 25687758 27036022 27452906
PTP4A3 RPTOR â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 17409395 19440036 19945467 20609352 21084277 23691193 24030100 24376839 24696260 25136802 26597054 27328425 27572739
SMAD4 PTP4A3 â—¼   DOWN_REGULATES ✅ - 21.0 1.0 ACSN 11074002 11279127 11792802 12702545 12809600 15265520 16713975 18471976 20609352 21053359 21084277 21614932 21811102 22073279 22970020 23178297 24403062 25139404 27222233 27526109 9389648
PTP4A3 TIMP2 â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 10048576 16617148 16831886 17563753 17671186 18832382 20731704 21317430 22406545 23691193 24376839 7512751 7528107
PTP4A3 RHOA â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 16540666 17192274 17409395 18268019 20681446 22677902 22825514 23691193 24030100 24376839 25687758 27036022 27452906
PTP4A3 SNAI1 â—¼   REGULATES ✅ 13.0 1.0 ACSN 10048576 16617148 16831886 17563753 17671186 18832382 20731704 21317430 22406545 23691193 24376839 7512751 7528107
RAC1 RPTOR â—¼   PHYSICAL_INTERACTION 40.0 1.0 ACSN 10702316 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18000759 18372248 18492954 19022819 19143636 19151919 19225151 19244117 19446321 19568798 19706736 19864431 20138985 20547845 20805416 21157483 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
RAC1 RPTOR â—¼   SHARES_COMPLEX 40.0 1.0 ACSN 10702316 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18000759 18372248 18492954 19022819 19143636 19151919 19225151 19244117 19446321 19568798 19706736 19864431 20138985 20547845 20805416 21157483 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
RAC1 RPTOR â—¼   ENZYMATIC_REACTION ✅ 40.0 1.0 ACSN 10702316 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18000759 18372248 18492954 19022819 19143636 19151919 19225151 19244117 19446321 19568798 19706736 19864431 20138985 20547845 20805416 21157483 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
RAC1 RPTOR â—¼   DOWN_REGULATES ✅ - 40.0 1.0 ACSN 10702316 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18000759 18372248 18492954 19022819 19143636 19151919 19225151 19244117 19446321 19568798 19706736 19864431 20138985 20547845 20805416 21157483 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
SRC RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22163037 17991704 21798346 26816343 29036929
RAC1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23331499 26430964 16189514 11021801
SMAD4 SNAI1 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16179589 16510505 16617148 16713975 16831886 17018611 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18768831 18832382 19208835 19412634 19597490 20731704 21041997 21042762 21199805 21317430 21577210 21614932 21883379 22006115 22331441 22406545 22514743 22945800 8515656 9389648
SMAD4 SNAI1 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16179589 16510505 16617148 16713975 16831886 17018611 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18768831 18832382 19208835 19412634 19597490 20731704 21041997 21042762 21199805 21317430 21577210 21614932 21883379 22006115 22331441 22406545 22514743 22945800 8515656 9389648
SMAD4 SNAI1 â—¼   UP_REGULATES ✅ + 41.0 1.0 ACSN 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16179589 16510505 16617148 16713975 16831886 17018611 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18768831 18832382 19208835 19412634 19597490 20731704 21041997 21042762 21199805 21317430 21577210 21614932 21883379 22006115 22331441 22406545 22514743 22945800 8515656 9389648
SRC STAT3 â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 16472776 17192274 19930715 22131018 22677902 23589069 23691193 24030100 24403062 25687758 27036022 27452906 29556339
SRC STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 11839738 10918587 9344858 7543024 15322115 10358079 14978237 11294897 7690989 16189514 12637327 11438544 10748192 7657660 12817007 9355737 11152457 10982844 7592750
SRC STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 88.0 1.0 Omnipath 19901323 10918587 9305919 8272872 29036202 9344858 12626508 10815799 16497976 15592455 16713569 17389395 12576423 11350938 9484840 11294897 28978186 18070987 12244095 27472461 21690253 23928694 22303479 8657134 11404481 9083098 14963038 8626374 17016520 9566874 10982829 15212693 11940572 11429593 14551213 15037656 15313931 11850821 9154828 9582023
TYK2 STAT1 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
STAT1 STAT3 â—¼   DOWN_REGULATES ✅ - 46.0 1.0 ACSN 10485906 10754326 10820262 10952726 11134049 11399519 11830590 11875494 11964313 12193701 12223527 12433365 12796776 12811837 12907458 12967644 14607900 14607933 14660645 14764699 15465827 15644117 15699106 15814715 16127449 16878026 17016554 17260466 17404308 17485448 17513775 17559085 17689680 18272812 18345002 19833085 19879327 21097505 21263073 21930765 23390297 25960930 6357187 7594497 8683106 8871614
STAT1 STAT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19122651 17558387 22693070
STAT3 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 25609649 8662591 12070153 31462771 25241761 11722592 8710878 9794795 23268184 15284024 16189514 9535918 11594781
TYK2 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 68.0 1.0 Omnipath 11839738 10918587 15261459 8232552 7543024 15322115 23331499 8780896 10435617 24243840 11294897 7690989 14764663 18988627 12637327 11438544 10748192 14565860 7657660 12817007 23257612 29145629 9355737 11152457 23124025 18389480 10982844 7592750
TYK2 STAT3 â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
TYK2 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 29145629 21098725 12626585 10542297 23331499 15261459 8662928 30910759 23673666 14565860 12023369 30029643 14764663 18389480 23124025 25516297
MSH2 MSH2 â—¼   KO_DOWN_REGULATES ✅ - -6.48 6.47 PKG 28854368