Protein list:

Seperate proteins by space | Example

Select nodes using shift click or drag to add to this list
Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

Note this may take some time with > 30 proteins
Filter Graph:

0.5
Layout:
  🔂

Click a node or edge for more data...
Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
GRB2 ACTN4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 BAD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
SYK CBL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5220991 8621719
LYN CBL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5220991 8621719
FYN CBL â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 5220480 7642581
SHC1 CBL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5220991 8621719
LCP2 CBL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6548125 9716598
HCK CBL â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8981370 20489731
SFN CBL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11697890 8005785
FYN CBL â—¼   PHOSPHORYLATION ✅ 0.8 0.8 mint 5217342 15556646
CBL FYN â—¼   PHOSPHORYLATION ✅ 0.8 0.8 mint 5217342 15556646
CBL SRC â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5219404 17141222
CBL MET â—¼   UBIQUITINATION ✅ 2.0 0.8 intact 5215187 11894096
FGR CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12435267 7721825
CBL PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17635922 10514377
CBL PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17635922 10514377
CBL PIK3CD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17635922 10514377
ESR1 CXCL12 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18563714
ESR1 CXCL12 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16912174
BMX EGFR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
PLCG2 EGFR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
EGFR CRKL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16729043 5218694
EGFR HRAS â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
EGFR GRK2 â—¼   COLOCALIZATION 2.0 0.8 intact 5217433 15620700
EGFR HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 17673906
EGFR PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 1845983
FOXO3 SFN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10102273 14701673
FOXO3 PIK3R1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19056725 21752881
FOXO3 AKT1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 10102273 5211323
CCR10 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PLCG2 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
FYN GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9694876 7737275
CD80 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9694876 7737275
CD86 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9694876 7737275
LYN GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9209406 8400282
LCK GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9694876 7737275
PIK3CA GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
GRB2 ACTG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 AIRE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GRB2 HNRNPK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 PPIA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 HSP90AB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 ACTN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
TEC GRB2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 11406363 15214048
VAV1 GRB2 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
FGFR1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9480847 16713569
GRB2 ITK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10636929
GRAP2 HNRNPK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
HNRNPK HCK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12029088 5215418
SRC HSP90AA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16844778 0604705103
CTNNB1 HSP90AA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HSP90AA1 AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12799359 11988487
HSP90AA1 IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
FOS ICAM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11356008 9218873
TNF ICAM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21474822 22846676
ICAM1 CDH5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18783313 26556953
HSP90AB1 IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
ACTG1 IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
PIK3CD LYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11598010 12506011
SHC1 LYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7516469 5220322
LYN ADAM15 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218167 16374509
LYN PLCG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15644415 8034732
LYN PIK3R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11598010 12506011
LYN CRKL â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11443118 11124936
LYN PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11598010 12506011
LYN PIK3R5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11598010 12506011
LYN SOS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9209406 8400282
LYN PIK3CB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11598010 12506011
LYN PRKCA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10592173 16713446
NFATC4 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16219765 17194453
NFATC4 TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17242187 16489119
AIRE PIK3R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PLCG1 PIK3R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6805619 9020117
HCK PIK3R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12029088 5215418
PIK3R1 LCK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5220762 8246987
PIK3R1 CD80 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12670391 8621607
PIK3R1 PLCG2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PIK3R1 VAV3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7033842 16982329
PIK3R1 GNAQ â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16268778 18515384
PIK3R1 SOS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PIK3R1 CD86 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12670391 8621607
PIK3R1 GAB1 â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 10978177 6731241
VAV1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16713569 11331248
BCAR1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 27447856 10799562
GNB5 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23109003 17169327
CD2 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8557753
PIK3R1 VAV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16713569 11331248
SFN BRAF â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15778465 5217604
SFN BCAR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15778465 5217604
SFN AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20005908 8009659
HNF4A TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20621834 16771709
CD3G VAV3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8986718 16546099
SYK VAV3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8986718 16546099
VAV1 VAV3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9705280 11804587
CD247 VAV3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8986718 16546099
VAV2 VAV3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9705280 11804587
ITK VAV3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12186560 23109003
ITGB1 CRKL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0807543105 19168626
CRKL SOS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9209406 8400282
ITGB1 CRKL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19168626
GNAI3 ADCY1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 8327893 19703466
CCL21 CCR7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8383238 7851893
GNGT1 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17419683 16537363
SRC LCP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6546918 15929943
PLCG1 LCP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6546918 15929943
SHC1 LCP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6548125 9716598
LCP2 HCK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12029088 5215418
LCP2 FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6546918 15929943
GRAP2 LCP2 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
LCP2 PLCG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10469124 16189514
FOS EZR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19164283
SOS1 SHC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 9544989 6547749
SRC SHC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10964917 8755247
CD3E SHC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6731413 11855827
LAT SHC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10811803 8663278
SHC1 FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7516469 5220322
SHC1 CD247 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7544002 6730386
FGFR1 SHC1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 17496910 25467007
PRKCA SHC1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7929214 12052829
HRAS SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17138645
FGR SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10329689 23109003
HCK SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10329689 23109003
SHC1 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7537361
VAV1 SYK â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8986718 16546099
PIK3CA SYK â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15536084 11907067
PIK3CB SYK â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15536084 11907067
SYK PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9720763 10592173
DOK1 ITGB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19118207 12606711
WAS LCK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7208262 16107303
PIK3R2 LCK â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15536084 11907067
LCK PIK3CB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15536084 11907067
LCK CD28 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8946678 9973466
LCK CD86 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8946678 9973466
LCK CD80 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8946678 9973466
LCK FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8946678 9973466
HLA-DRA LCK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD3D LCK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD4 LCK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
LCK CD3E â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
LCK CD3G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
LCK CSK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15489916 15489910
CD2 LCK â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 6548030 9677430
FYN LCK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17570479 22043010
FYN CD2 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 6548030 9677430
SRC CSK â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16005629 15157149
FYN CSK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7524477 6730342
CD4 CSK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15489916 15489910
CD3D CSK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15489916 15489910
CD3E CSK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15489916 15489910
CD247 CSK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15489916 15489910
HLA-DRA CSK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15489916 15489910
CD3G CSK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15489916 15489910
VAV1 CD247 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8986718 16546099
PIK3R2 CD247 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12869549 15536084
CD247 PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12869549 15536084
CD247 PIK3CB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12869549 15536084
CD247 VAV2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8986718 16546099
CD3G CD247 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD3E CD247 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
HLA-DRA CD247 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD3D CD247 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TEC LAT â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 11406363 15214048
SOS1 PLCG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GRAP2 PLCG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11390650 11048639
PLCG1 AIRE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
TEC PLCG1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 11406363 15214048
TEC PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10823839 24317039
MET PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8662733 7513258
CD3G VAV1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8986718 16546099
VAV1 TEC â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11328862 7651724
VAV1 VAV2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9705280 11804587
VAV1 CDC42 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18511940 6743311
HRAS VAV1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 1569084 1377053
PIK3CA VAV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11094073 9891995
SRC VAV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1531699 1311423
VAV1 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1531699 1311423
AIRE FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
SOS1 FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
CCR10 FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
SRC FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219079 16966330
PIK3R2 FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15536084 11907067
FYN CD28 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8946678 9973466
FYN PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12670391 8621607
FYN AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FYN CD86 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8946678 9973466
FYN CDC42 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11817894 15788770
FYN CD80 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8946678 9973466
FYN PIK3CB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15536084 11907067
FYN WAS â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5216858 14707117
FYN VAV2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17570479 11262396
SOCS1 IFNG â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10421843 10064597
ESR1 CCL5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12603855 26790618
NR4A3 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12810687 17941092
HRAS SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12695509 5216326
HRAS PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9069260 21779497
CTNNB1 CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16132617 12200448
CD80 PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12670391 8621607
CCR7 CD3E â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8409790 22922463
CSF2 SOS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 1465135 8294403
CD86 PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12670391 8621607
SOS1 SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ACTN1 SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6672010 16291744
SRC ACTN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6672010 16291744
SRC SPRR2A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7216055 18155796
SRC CDC42 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11817894 15788770
SRC ARRB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16432186 0510562103
SRC AIRE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
AFDN SRC â—¼   COLOCALIZATION 2.0 0.8 intact 5219918 17491594
SRC FOS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17160021 22105363
VAV2 CDC42 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8994827 9032261
GRAP2 CD28 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6731212 10820259
CD28 PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9915850 18006698
CD4 HLA-DRA â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD4 CD3G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD4 CD3D â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD4 CD3E â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD3G VAV2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8986718 16546099
NR4A3 TEC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22739199 9177279
CXCR4 CXCL14 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23669361 8427967
CXCL14 CXCR4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 32239134 28360196
PRKCZ AKT1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 18650932 7232391
PIK3CA FOS â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PRKCZ F11R â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17057644 5219258
PIK3CG PRKCZ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8765021 16527821
BRAF PRKCA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16810323 5218785
PRKCA PRKCE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16810323 5218785
SPRR2A HCK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7216055 18155796
HCK ADAM15 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218167 16374509
HCK PIK3R2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12029088 5215418
GNB5 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23109003 17169327
GNB3 GNAQ â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25675501 15889144
GNAQ GNB4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25675501 15889144
GNAQ GNB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25675501 15889144
GNB2 ADCY2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1962211 1312225
GNAI1 ADCY1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15922020 19703466
HLA-DRA CD3G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
HLA-DRA CD3D â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
HLA-DRA CD3E â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
PRKCE ADCY7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17185372
PRKCE ADCY5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17185372
MET PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10871282 10648629
CD3G PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12869549 15536084
PIK3CD PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9885561 10455108
PIK3CA GNAQ â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16268778 18515384
PIK3CA PIK3CB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9885561 10455108
GNG3 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17419683 16537363
CTNNB1 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16219695
GNAQ GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20399743
GSK3B CTNNB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219694 17318191
CTNNB1 CTNNA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12640114 5216233
ESR1 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16628468
CTNNB1 NR4A3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 21362399
PIK3CD PIK3CB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9885561 10455108
AKT2 GSK3A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9065430 16023596
PIK3R2 PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8596638 11733063
AFDN CTNNA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11907041
SOS1 GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11707404
GAB1 PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8596638
GAB1 PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8596638
GAB1 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11707404
CD3G PIK3CB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12869549 15536084
WAS FGR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5220415 7565724
PIK3R2 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19531499 9651378
GRK2 CCR5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10085131
CD3D CD3G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD3D CD3E â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD3E CD3G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
PIK3R2 CD3G â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12869549 15536084
NR4A3 BTK â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11058574 19843184
IBTK BTK â—¼   COLOCALIZATION 2.0 0.8 intact 11577348 5214610
CCL18 CCR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 23951310 32103204
CX3CR1 CX3CL1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9024663 9390561
CCL25 CCR9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10229797 10640743
CBL HCK â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
GRB2 MET â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
FGFR1 PIK3R1 â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
SYK PLCG1 â—¼   PHOSPHORYLATION ✅ + 0.8 0.8 Signor 8657103
VAV2 CBL â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 15345594 11313921 20940296 11262396
PIK3R1 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 16273093 5218056
SHC1 FGFR1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 16189514 16713569 7514169 7559490 18022941
LCK CD3E â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 14523017 11855827
SFN SOS1 â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
BCAR1 FYN â—¼   PHYSICAL_INTERACTION 816.0 0.81 STRING 36370105
CD28 GRAP2 â—¼   PHYSICAL_INTERACTION 817.0 0.81 STRING 36370105
BTK CDC37 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
CSK CDC37 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23455922 31980649
FGFR1 CDC37 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31980649 18022941
GRB2 CSK â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31980649 21706016
SHC1 PIK3R1 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 16219545 5217992
CRKL SOCS1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 25814554 29991678
GNAI3 GNB2 â—¼   PHYSICAL_INTERACTION 819.0 0.82 STRING 36370105
AKT1 CSK â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 26344197 19262695
FOS ESR1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17317669 25303530
AKT1 HSP90AB1 â—¼   PHYSICAL_INTERACTION 820.0 0.82 STRING 36370105
PIK3CG PIK3R5 â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
HSP90AA1 SRC â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
KHDRBS1 LYN â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
CXCR2 GNAI1 â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
AKT1 BAD â—¼   PHOSPHORYLATION ✅ - 0.82 0.82 Signor 9346240
AKT1 GSK3B â—¼   DOWN_REGULATES ✅ - 0.82 0.82 Signor 15829723
AKT1 GSK3B â—¼   PHOSPHORYLATION ✅ - 0.82 0.82 Signor 23552696
CBL FGR â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 7721825 12435267
LCP2 SHC1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 9716598 16189514
CXCR2 ARRB1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16189514 11170396
SHC1 PLCG2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 12135708 10623845
LCK KHDRBS1 â—¼   PHYSICAL_INTERACTION ✅ 0.83 0.83 mint 7208262 16107303
CSK ARRB1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 10753943 19262695
ARRB2 SRC â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 19202075 19122674 11877451 23242524
SOCS1 VAV2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 10022833 29991678
ESR1 ACTN1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 23403292 21182205 19805454 31527615
ESR1 MBD2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 20300195 31527615
EGFR HCK â—¼   PHYSICAL_INTERACTION 833.0 0.83 STRING 36370105
GNAI1 GNGT1 â—¼   PHYSICAL_INTERACTION 834.0 0.83 STRING 36370105
CD247 CD3D â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CD3D CD3G â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
BAD SFN â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
BTK CBL â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
CBL LCP2 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
SRC CBL â—¼   PHYSICAL_INTERACTION ✅ 0.84 0.84 mint 6538879 18273061
SRC CBL â—¼   PHOSPHORYLATION ✅ 0.84 0.84 mint 5219404 17141222
FGR CDC37 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 32707033 31980649
LCK CTLA4 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 9712716 9973379
GRB2 PPIA â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 31980649 12577067
LYN HCK â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 32707033 31980649
LAT LCP2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 24584089 16189514 9489702 23514740
SRC BMX â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 16189514 10688651
SHC1 DOK1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 11071635 22974441 10822173
CSK LCK â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 15144186 31980649 12485116
ARRB1 SRC â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 33844281 19202075 16432186 23242524
HLA-DRB1 HLA-DRA â—¼   PHYSICAL_INTERACTION ✅ 0.84 0.84 mint 5220278 7477400
EGFR PLCG1 â—¼   PHOSPHORYLATION ✅ + 0.84 0.84 Signor 1689310
ARRB2 SRC â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
GSK3B CTNNB1 â—¼   PHOSPHORYLATION ✅ - 0.84 0.84 Signor 16293724
ITGA4 ITGB1 â—¼   PHYSICAL_INTERACTION 844.0 0.84 STRING 36370105
CD8A LCK â—¼   PHYSICAL_INTERACTION 848.0 0.84 STRING 36370105
ACTN4 ESR1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 21078666 19805454 25604459
GSK3B CDC37 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 23455922 29568061 33961781
ITK CDC37 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 28514442 32707033 33961781
CDC37 HCK â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 11413142 32707033 31980649
PLCG1 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 9020117 6805619
SRC GRB2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16189514 16713569 11964172 9016807 12624098
SHC1 LYN â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 7516469 7650013
SRC LYN â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 32707033 9169421 18070987 22581261
LYN TEC â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 11071635 9446655 8621063
CRKL SOS1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 9162067 26496610 33961781 32203420 23397142
LCK LCP2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16354835 8702662 10556826 21725281
PLCG1 SHC1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 8662733 8155326 10652211
BCAR1 LCK â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 9020138
SRC PLCG1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 1689310 7510703 16713569 7682059 8657103 8885868
KHDRBS1 FYN â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 8374603 22641034
CD86 CD28 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 27708164 21931534 11021528 7513726
SRC ESR1 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 17284441 6169640
SRC DOK1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 11071635 22974441
AKT2 AKT1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 28514442 12149249 9736715 12176337 11445557 33961781 14500673 11278835 11546794
BTK HCK â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 32707033 8058772
SOS1 HCK â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 12029088 23397142 17141806
FGR DOK1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 11071635 22974441
GAB1 PLCG2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 11507676 24728074
BTK PLCG2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 11507089 12093870 17290227 10981967
CD8A CD8B â—¼   PHYSICAL_INTERACTION 851.0 0.85 STRING 36370105
HNRNPK KHDRBS1 â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
EGFR VAV1 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
HCK SOS1 â—¼   PHYSICAL_INTERACTION 856.0 0.85 STRING 36370105
GAB1 GRAP2 â—¼   PHYSICAL_INTERACTION 856.0 0.85 STRING 36370105
MET CBL â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 6538879 18273061
GRAP2 CBL â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 25814554 12496419
CBL CSK â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 11149930 19380743
MET CBL â—¼   UBIQUITINATION ✅ 0.86 0.86 mint 11894096 5215187
LCK CDC37 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 34079125 31980649
SOCS1 EGFR â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 22973453 29991678 12070153
VAV3 EGFR â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 24797263 10938113 11094073 22973453 25754235
PIK3R1 GRB2 â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 5220480 7642581
ITK GRB2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 10636929 8985255
CCR3 CCL7 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 8642344 10733106
CCR4 CCL5 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 8573157 12270118
CARD11 BCL10 â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 7228517 19444310
MET PLCG1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 8662733 24728074 7513258
AKT1 BRAF â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 10869359 25241761 28628118 28205554
CDH5 CTNNB1 â—¼   COLOCALIZATION ✅ 0.86 0.86 mint 5219258 17057644
CCL23 CCR1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9886417 9558365 10660125
BCAR1 GRB2 â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
CARD11 IKBKG â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
AKT1 PRKCZ â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
CBL VAV2 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
CDC42 PIK3R1 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
ESR1 FOXO3 â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
CCL5 CCR3 â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
SFN BAD â—¼   PHYSICAL_INTERACTION ✅ 0.87 0.87 mint 20005908 8009659
AKT1 CDC37 â—¼   PHYSICAL_INTERACTION 869.0 0.87 STRING 36370105
BRAF CDC37 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 27034005 31980649 17979178 33961781 27684187
EGFR ARRB2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24658140 25402006 31980649
EGFR VAV2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24797263 10938113 11516622 19531499 22973453 12454019 10618391 18271526 20940296
EGFR ITK â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24658140 25402006 31980649
ESR1 FOXO3 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 18312651 11435445
SOCS1 GRB2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 10022833 29991678
LYN MET â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 34079125 24728074
LYN BTK â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 11226282 8058772 11598012 8629002 8630736
LYN GAB1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 34079125 24728074
CCR1 CCL7 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 8530354 7545673 9336350
CCR5 CCL3 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 9334377 10477718 9169459 11700073 9468473
GAB1 LCK â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 34079125 24728074
CSK FYN â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 16713569 8262983 7524477 1985196
LAT ITK â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 12186560 10506192
ITK FYN â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 10636929 16713569 8810341
FYN PLCG2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 8395016 16189514 16713569 7682059 12181444 15144186
CCR3 CCL5 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 11449371 10733106 8642344 7622448 9289016
CCR1 CCL5 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 11449371 12270118 8530354 7545673 14637022 11116158 7622448 9115216 9289016 10910894 9336350
HRAS BRAF â—¼   PHYSICAL_INTERACTION ✅ 0.87 0.87 mint 34591642
HRAS BRAF â—¼   PROXIMITY ✅ 0.87 0.87 mint 30194290
SOCS1 ITK â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 10022833 29991678
SOCS1 MET â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 25728680 24728074
GNAI1 GNAI3 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
KHDRBS1 PLCG1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
HCK PIK3CB â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
HRAS PIK3CA â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
CBL VAV1 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
FYN CTNNB1 â—¼   PHOSPHORYLATION ✅ - 0.87 0.87 Signor 12640114
EGFR VAV3 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
BCL10 IKBKG â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
LCP2 VAV1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
FGR WAS â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
PIK3R2 PIK3R3 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
CD28 GRB2 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
PIK3R1 PIK3R2 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
PIK3R1 SHC1 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
CD247 LCK â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
EGFR SFN â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
CRKL PIK3R1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
ACTN1 ACTN4 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 22863883 22939629
LCP2 CBL â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10477741 10204582 9716598 19635790
CDC37 AKT1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 22504172 12176997 31980649 24869908
ESR1 EGFR â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16713569 28065597 20935677 11887937 17284441
EGFR HCK â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 31980649 24658140 23397142 25402006
AKT1 FOXO3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 21621563 10102273 25241761 21775285
LYN DOK1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11071635 11825908
LYN FGR â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 34079125 32707033 31980649
SHC1 SRC â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
SOCS1 FYN â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10022833 16713569 29991678
CD4 CXCR4 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10816381 15660419 14592831
SOCS1 TEC â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 29991678 9341160
GAB1 MET â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
AKT1 PIK3CA â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
CRKL EGFR â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
LCP2 PLCG1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
LAT PLCG1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
HCK KHDRBS1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
CBL PLCG1 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
GRB2 KHDRBS1 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
ITK LCP2 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
CRKL GAB1 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
FYN WAS â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
AKT1 BAD â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
EGFR PIK3R2 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
GNAI3 GNB4 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
EGFR HSP90AA1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
BCAR1 CRKL â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
FYN KHDRBS1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
CBL LCK â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
EGFR MET â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
CD3D CD3E â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
CBL SHC1 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
CBL PIK3R2 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
ESR1 HSP90AA1 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
CTNNA2 CTNNB1 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
EGFR ACTN4 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24658140 25402006 31980649 26320552
EGFR CDC37 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 25036637 31980649 12471035 24189400 23956138
EGFR FGR â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24658140 25402006 31980649
EGFR LAT â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24658140 25402006 31980649
EGFR GRAP2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22973453 24658140 25402006 31980649
EGFR AKT1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24658140 25402006 31980649
EGFR DOK1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24658140 25402006 31980649
EGFR LCP2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24658140 25402006 31980649
EGFR CRKL â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 31980649 24658140 25402006 18271526 25754235 16729043 23397142
EGFR ARRB1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24658140 25402006 31980649
GRB2 LCP2 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
CD28 GRB2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 9694876 27927989 7737275 7584133 8576157 24475931
HSP90AA1 HSP90AB1 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
LYN PLCG2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 8395016 10981967 7682059 12181444 15144186
BCAR1 CRKL â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 9498705 8810278 10753828 22974441 8978305 18835194
SHC1 CSK â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10037694 19380743 12048194
SHC1 MET â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 7731718 24728074 9660480
CD2 FYN â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16189514 16713569 9677430
CSK SRC â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12387813 17525734 9208935 7678701 21746865 7513429
GRAP2 LAT â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16189514 10021361 10224278
LAT PLCG2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24642916 10469124 16189514 27221712
ITK PLCG1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12163161 10586033
SRC FYN â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 31980649 19711372 9169421 33961781 16966330
CCR5 CD4 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10816381 30542158 15660419
EGFR HSP90AB1 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
PIK3R1 SRC â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
EGFR GAB1 â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
EGFR PIK3R1 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
IKBKG TNF â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
GRB2 WAS â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
GRB2 VAV1 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
CBL LYN â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
KHDRBS1 SRC â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
CBL EGFR â—¼   UBIQUITINATION ✅ - 0.89 0.89 Signor 20332299
EGFR CBL â—¼   RELOCALIZATION ✅ + 0.89 0.89 Signor 16829981
EGFR CBL â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 27059931 7657591 8665853 27903975 15107835 24797263 28791635 9756944 23799367 23175185 28198003 12734385 14505571 20940296 19155296 10635327 15117950 22833562 29629558 12061819 8662998 10086340 33762435 11994282 20877636 32714745 25005938 31182136 19578043 7782294 24714105 10799548 23158001 26055326 33617900 23153581 15210722 25872741 15657067 19947936 10428778 18508924 16969069 17971399 15962011 19531499 25521828 23774213 22976291 31959764 22591401 18255265 15735736 16713569 20562913 17880946 16914641 9890970 22394513 16729043 32114396 17995934 17182860 18319245 18271526 17545148 15383614 25140053 32377695 15465819 33627783 8798643 25754235 15282549 26177020 22266821 16923119 17242169 30544639 12604776 11239464 9130710 19225046 11370743 21772844 16105874 18273061 7592693 23897813 17486068 16246327 23457600 32904620 12803489 31120930 15668240 22203672 23418353 20124286 28541302 33323455 10092522 14627991 15677445 15159412 20308550 16849543 12593795 19836242 9121472 19713535 18316398 11408594
SRC CBL â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 29899407 17094785 16713569 18273061 7782294 12941616 10829062 31120930 15135048 17141222 18996392 8635998 11994282 22203672 19861161 16636290
BTK CBL â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10826882 10427990 9408950 7629518
HCK CBL â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 22974441 9890970 11896602 10799548 10092522 11239464 8995358 11994282
CBL MET â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11894096 25241761 18273061 19433454 21222362 19450681 21163258 16397241 17533376 15123609
CBL PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25814554 17635922 10514377
CDC37 SRC â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 32707033 33961781 31980649 11085988
HRAS CDC37 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16024644 15118125 15284455
CD86 CTLA4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11021528 25241761 7694153 12606712 21982860 7513726 11162656 12582153 11279501 12071705
CTLA4 CD80 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11279502 20587542 21982860 7545666
SRC EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 17284441 6169640
PLCG2 EGFR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25241761 31980649 22973453 24658140 16273093 25402006
EGFR MET â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20624308 24189400 21918175 24362532 10722725 23866081 26551075
EGFR PLCG1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 1689310 11983899 14568990 15144186 12803489 12601080 24797263 9756944 9207933 19605547 7993895 7693694 9020117 12061819 16273093 25754235 16713569 22973453 7682059 8657103 8885868
EGFR CSK â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 24797263 31980649 24658140 25402006 16729043
EGFR GAB1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 23066441 31980649 10913131 9890893 24658140 10648629 21278788 25402006 10734310 18271526 19401591 11432805
EGFR LYN â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31980649 22973453 24658140 23764002 25402006 16799092 34079125 23866081
EGFR BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17145710 17570479 15951569
FOXO3 PIK3CA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19299143 18644865
SHC1 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18385518 15930121
PIK3CD GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11002419 10995764 10448070
PIK3CB GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11002419 10995764 10448070
CDC42 GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
BCAR1 GRB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10085298 16105984 8649368 8700507 10822386
MET GRB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11063574 15546961 9660480 19433454 21222362 7511210 8662889 11439336
VAV3 GRB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 32296183 18654987 12577067 11094073 21706016 20936779
LAT GRB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 7544353 16906159 12186560 16189514 9489702 16713569 8063801 16938345 10811803 12359715 23460737 11368773
FYN GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7499280 9344857
HRAS HSP90AA1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16024644 15118125 15284455
LYN VAV1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9209406 8677749 7539782
BCAR1 LYN â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9581808 9020138
LYN PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10318860
PIK3R1 CD28 â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 6730476 7807015
PIK3R1 PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8596638 14665640 11733063
ESR1 CCL7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20034404
CXCR1 CXCL6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 1840701 3260265 9164944
SYK MS4A2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8071371 7528327 8910399
VAV1 CRKL â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9209406 8677749 7539782
DOK1 CRKL â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11071635 11553620 9822717 25814554
CCR7 CCL19 â—¼   PHYSICAL_INTERACTION 3.0 0.9 ACSN 11698286 17035340 19759904
CCR7 CCL19 â—¼   PROTEIN_INTERACTION 3.0 0.9 ACSN 11698286 17035340 19759904
SOS1 LCP2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11390650 10021361 10224278
LCP2 WAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10747096 16189514
CCL16 CCR1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7679328 9207005 8048929
CCL16 CCR8 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7679328 9207005 8048929
VAV1 SHC1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9209406 8677749 7539782
PIK3CD SHC1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11002419 10995764 10448070
GRAP2 SHC1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11390650 10021361 10224278
SHC1 PIK3CA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11002419 10995764 10448070
SHC1 PIK3CB â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11002419 10995764 10448070
SHC1 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20935677 11773443 16713569
ITGB1 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19889638 10964917
PLCG1 SYK â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 7517665 8657103 15161916
CD3G SYK â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 7517665 8657103 15161916
CD247 SYK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9295038 7761456 7522230
SYK PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15536084
AKT1 ITGB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16256741 10896934
SRC ITGB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10592173 11723131 11259684
FOS CD40LG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11160303
LCK LAT â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16938345 12186560 12359715 14523017
CD2 LCK â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 19398758 19494291 26794910
LCK PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7682059 17570479 1500851
CD2 IL2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 19398758 19494291 26794910
CD2 CD4 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 19398758 19494291 26794910
CD2 IFNG â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 19398758 19494291 26794910
CSK ARHGAP35 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10592173 9819392 18829532
PLCG1 CD247 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7517665 8657103 15161916
PLCG2 CD247 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7517665 8657103 15161916
BCL10 AKT1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16280327 24462114 24412244
FYN LAT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16938345
LAT PLCG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 27221712 10469124 16189514
CD3G PLCG1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7517665 8657103 15161916
PLCG1 FGFR1 â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 8321198 6730542
FGFR1 PLCG1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12601080 1689310 1656221 25241761 23063561 8321198 9660748 20932831 18022941 19665973 15117958
SRC PLCG1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15879121 20807769 11600407
FGFR1 PLCG1 â—¼   PROXIMITY ✅ 0.9 0.9 mint 8019672 20932831
PLCG1 FGFR1 â—¼   PROXIMITY ✅ 0.9 0.9 mint 8019672 20932831
VAV1 CD80 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18295596 15886116 10849438
VAV1 CD86 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18295596 15886116 10849438
FYN GSK3B â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 17607942 15676027 15652488
FYN ARHGAP35 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18541700 23144976 11536198
CCR5 CCL5 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11449371 10477718 10488147 9334377 8663314 14637022 9207005 11116158 9289016
SRC BCAR1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 604342200 7033822 17038317
CD28 CD80 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 2164219 7964482 21982860 1847722 7545666
FOS IL4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7665092 10772943 9133600
ESR1 CD86 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20034404
SRC ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 24498420 14766010 15604093 11013076 27420286 29720121 12736255 18451880 15140878 23065768 17043237 17627277 7539106 11032808 17363140 20935677 14963108 11564893 12630920 22328528 15020686 15784253 17921256 24051437 10454579 17400812 17284441 16957778
SRC MET â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 24034250 20624308 9837958 24728074
ESR1 SRC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20160136 20460377 22865929
AFDN SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17491594
SRC PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25814554 22402981
SRC ARHGAP5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7542246 24858043 10592173
GRAP2 CD28 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 24475931 27927989 10820259
ITK PLCG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15184383
TEC DOK1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11071635 11825908 10823839
ICOS PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16217039
CCR5 CXCR4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12429730 15660419 18632580
AKT1 GSK3B â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19713527 8524413 23824745 16009706 29464284 20856200 19995607 16123141 20682768 27563096 14645548 15688030 22337773 11035810 17428466 18505846 15470047 14701753 16282323
PRKCZ AKT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18353613 9512493
GNB5 PRKCA â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11601986 11292825 12499365
PRKCA ADCY5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8206971 7759492
PRKCA BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 1386920 16810323 12917261
PRKCA GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19836308
GSK3B GNB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
GNGT2 GNB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8636150 19168127 19376773
GNB2 GRK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 1325672 8416978 1962211
PIK3CA SOS1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 21653832 16456001 10068651
GRK2 GNAQ â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10567430 16339447 10727532
GNAQ BTK â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9770463 11742120 9305846
AKT2 BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10869359
PRKCB BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 1386920 17570479 12917261
CTNNB1 HNF4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12944908 25241761
PIK3CD GAB1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11002419 10995764 10448070
ESR1 CLDN4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20034404
ARRB2 ARRB1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 24069330 17353931 33961781 17620599
GRAP2 SOS1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11390650 10021361 10224278
PIK3CG GAB1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10194437 12506011 10455108
GAB1 PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10871282 8596638
PIK3CB GAB1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11002419 10995764 10448070
GAB1 PIK3R5 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10194437 12506011 10455108
PIK3CB SOS1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 21653832 16456001 10068651
PIK3R2 PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22402981 8596638 11733063
PIK3R2 SOS1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 21653832 16456001 10068651
IBTK BTK â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11577348 21482705 18596081
CD3G PLCG2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7517665 8657103 15161916
CCR10 CCL27 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10781587 10725696 10725697
CCR10 CCL28 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10781587 10725696 10725697
AKT1 GSK3A â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
CDH5 CTNNB1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
SOS1 HRAS â—¼   GTPASE_REACTION ✅ + 0.9 0.9 Signor 23132018
EGFR PLCG2 â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
EGFR SOS1 â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
GRB2 SOS1 â—¼   RELOCALIZATION ✅ + 0.9 0.9 Signor 23452850
GAB1 PIK3R1 â—¼   PHYSICAL_INTERACTION 907.0 0.9 STRING 36370105
CSK SRC â—¼   PHYSICAL_INTERACTION 907.0 0.9 STRING 36370105
GRB2 PIK3R1 â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
BCAR1 SRC â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
GNAI1 GNB4 â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
CBL MET â—¼   PHYSICAL_INTERACTION 909.0 0.91 STRING 36370105
SHC1 SOS1 â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
EGFR VAV2 â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
GRB2 CBL â—¼   RELOCALIZATION ✅ + 0.91 0.91 Signor 11823423
ACTG1 CDC37 â—¼   PHYSICAL_INTERACTION 0.91 0.91 HuRI 32296183
CTNNB1 GSK3A â—¼   PHYSICAL_INTERACTION 916.0 0.91 STRING 36370105
FYN CDC37 â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 28514442 25036637 31980649 33961781 32707033
FYN CTLA4 â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 9712716 25241761 9973379 16713569
LCP2 GRB2 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 17235283 5219525
CD28 PIK3R1 â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
CCL19 CCR7 â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 9153236 9507024
AKT1 ARRB2 â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 18191226 19122674 19262695
EGFR PLCG1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
EGFR GRB2 â—¼   PHOSPHORYLATION 0.92 0.92 Signor 11726515
ESR1 SRC â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
GRAP2 LCP2 â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
CD247 CD3E â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
CBL FYN â—¼   PHYSICAL_INTERACTION 925.0 0.92 STRING 36370105
SYK VAV1 â—¼   PHOSPHORYLATION ✅ + 0.92 0.92 Signor 11331248
GRB2 BTK â—¼   PROTEIN_INTERACTION 0.93 0.93 HIPPIE 19380743 20936779
CD247 SHC1 â—¼   PHYSICAL_INTERACTION 931.0 0.93 STRING 36370105
EGFR SRC â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
GNB3 GNGT1 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
GNB5 GNGT1 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
GNB2 GNGT1 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
GNB5 GNG5 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
GNB3 GNG11 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
GNB3 GNGT2 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
GNB4 GNGT2 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
CD3E CD3G â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
AKT1 GSK3B â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
PIK3CB PIK3R3 â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
CBL SRC â—¼   PHYSICAL_INTERACTION 936.0 0.93 STRING 36370105
PLCG1 SYK â—¼   PHYSICAL_INTERACTION 936.0 0.93 STRING 36370105
PIK3CB PIK3R2 â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
PIK3R1 CBL â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 5217342 15556646
AKT1 FOXO3 â—¼   PHYSICAL_INTERACTION 939.0 0.94 STRING 36370105
VAV2 GRB2 â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 11606575 12577067
GNAI1 GNAI3 â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 28514442 22939629 33961781 26186194
SOS1 HRAS â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 17084389 5219305
CD3G CD3E â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 20890284 9582308 2138083
PIK3CA PIK3R3 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
HRAS PIK3CG â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
AKT1 HSP90AA1 â—¼   PHYSICAL_INTERACTION 946.0 0.94 STRING 36370105
CD3E SYK â—¼   PHYSICAL_INTERACTION 946.0 0.94 STRING 36370105
PIK3CB PIK3R1 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
CBL SYK â—¼   PHYSICAL_INTERACTION 948.0 0.94 STRING 36370105
CBL LCK â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 7721825 8621719 8900205 8626543 9178909 16107303 11741956 11904433
SOS1 FYN â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 17474147 16713569 9856337
WAS CDC42 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 8625410 5221000
MET GAB1 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 10871282 10913131 10995442 10734310 9242692
CD80 CTLA4 â—¼   PHYSICAL_INTERACTION 950.0 0.95 STRING 36370105
ACTN1 ACTN4 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
CD86 CTLA4 â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
BRAF HRAS â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
AKT1 BAD â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 15998799 10358075 25241761 11500364 9381178 11994280 23085457 15722337 19667065 15784622
GRB2 CBL â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 5220480 7642581
EGFR CBL â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 16729043 5218694
SHC1 CBL â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 10570290 10025673 16713569 8621719 9541596 8662998 9461587 9434624 9234717 8950973 19380743 15677445
CBL LYN â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 7721825 12149655 9160881 18235045 8621719 7782294 12244174 15190072 33512474 32707033
CBL EGFR â—¼   COLOCALIZATION ✅ 0.96 0.96 mint 16914641 7033849 028274
SOS1 EGFR â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 24797263 16713569 26005835 9447973 23956138 19531499 7510700 20473329 19289468 25754235 18271526 31959764 10675333 8621459
PLCG1 GRB2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 16713569 7629168 7516467 9020117 21706016 10940929 16038803 9281317
GAB1 CRKL â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 25241761 10871282 24728074 30480076 10753869 23397142
GAB1 SHC1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 9804835 24728074 12808090 14982882
SHC1 SOS1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 8631299 10570290 10025673 8235613 8626525 9544989 10675333 10783152 8950973 7559490 19380743 16371368 9344843 7520523 8621459
CD2 LCK â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 8551220 16189514 9677430
CD4 LCK â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 17653867 16888650 16189514 15047060 11854499 12007789 8104794 8246987 17005671
GAB1 PLCG1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 8596638 11507676 24728074
SOS1 PLCG1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 16713569 17474147 9020117 10940929 10913276
GRAP2 GAB1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 12176364 24728074 10913131 33961781 12773374 26186194 9878555
FYN SRC â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
FYN CBL â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 17094785 8900205 15190072 9890970 25814554 8995358 12244174 10829062 12941616 9311917 12231245 16503409 9677430 8662998 119942 9535867 10092522 15208330 7642581 15556646 16713569 8621719 10629042 7782294 8626543 10799548 11239464
PLCG1 CBL â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 16503409 12803489 9712732 25241761 16713569 16467851 12061819 12941616 9234717 17372230
CRKL CBL â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 9162067 9129019 16982329 9590251 8621483 25814554 10907644 10608804 15107835 7545163 9092574 9195915 12244174 18835194 9311917 8524328 16503409 24886428 10657627 14604282 9820532 8662998 9461587 9851874 11399323 9344843 11157475 10204582 9660791 15556646 8978305 11553620 8626543 9988765 33961781 11263968 15358160 11133830
SHC1 EGFR â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 7518560 8034616 31980649 23956138 9544989 8610109 7542744 25402006 16729043 8665853 15657067 9742218 24797263 10049786 12577067 9756944 23799367 25187647 20935677 10766863 18271526 11408594 7506413 10635327 10595738 24189400 19531499 7542991 20473329 24430869 8662998 9020193 8887653 16273093 25754235 9388490 31959764 26551075 16713569 22973453 24658140 11196191 28065597 20067773 8810340 21278788 30544639 9130710 11370743
SRC EGFR â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 31980649 8845374 21573184 25402006 7506422 10075741 19704002 10971656 23175185 10777553 22227249 20935677 20624308 21268077 17158602 24189400 9020193 16713569 22973453 11983694 24658140 28065597 21278788 17284441 7797556 20333651 7527393 10358079
EGFR GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 19254954 7518560 31980649 9416834 7592693 23956138 14679214 10085134 7510700 27059931 21706016 25402006 16799092 16729043 8665853 15657067 24797263 12577067 8810325 7650032 11960376 23799367 25187647 8626525 10026169 19289468 18271526 21278786 7506413 17971399 8940013 20124286 11726515 9886492 10595738 24189400 9020117 19531499 20473329 9020193 8662998 8647858 1322798 8887653 10229072 16273093 25754235 31959764 11370743 16713569 21596750 9685397 24658140 31985874 22973453 11896612 20067773 17242169 19836242 8810340 21278788 30544639 7527043 9050991 11408594 8621459
SHC1 GRB2 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 8940013 6169950
SOS1 GRB2 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 5220480 7642581
LCP2 GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 8695800 11314042 10204582 8995445 15929943 12176364 25416956 32296183 9565634 10224278 7706237 20936779 19380743 17235283 9716598
GAB1 GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 11314042 22536782 10871282 31980649 10913131 11960376 9804835 9890893 20473329 21706016 33961781 20936779 19380743 9242692 8596638
PIK3R1 PIK3CA â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 20018188 7383613
GRAP2 LCP2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 16189514 15929943 25416956 21516116 17235283 32296183 17010654 31467278 10021361 20534575 10820259 12176364 12496419 26264872 10224278 27107012 29997244 32814053 12773374
LCP2 ITK â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 21725281 10636929 15388330 17420479 12190313 10556826
LCP2 PLCG1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 11390650 15929943 21725281 16467851 7706237
SRC SHC1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 10482988 16189514 7499252 9096689 9710204 18840094 8939605 9388490 26551075
LAT PLCG1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 7544353 9489702 16713569 16467851 16938345 10811803 27221712 24642916 9729044 11368773
BCAR1 FYN â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 10739664 32296183 9360983 16713569 17474147 31413325 9188452
SRC BCAR1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 10739664 10085298 10542110 21034468 17129785 17038317 11514617 10487518 16849545 12972425 12615911 15020686 12397603
CTNNB1 GSK3B â—¼   PHYSICAL_INTERACTION 969.0 0.97 STRING 36370105
SYK VAV1 â—¼   PHYSICAL_INTERACTION 970.0 0.97 STRING 36370105
ICAM1 ITGAL â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
CCL5 CCR5 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
CCR5 CD4 â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
CD4 LCK â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
FGFR1 PLCG1 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
SHC1 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 16729043 5218694
GRB2 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 16729043 5218694
LCP2 GRAP2 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 17235283 5219525
PIK3CD PIK3R1 â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
PIK3CA PIK3R2 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
SHC1 GRB2 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 12485888 21725358 31980649 9126968 7514169 7744881 8235613 11453982 8662733 8491186 7629070 8940013 10570290 8112292 12213123 11302736 8662998 8195171 7597091 8810340 32062451 9129019 16371368 12149229 10049786 8626525 7650032 8950973 9488479 24189400 15812354 12441060 19380743 26551075 22057045 10477741 28690151 16713569 7516467 9733714 11827484 11964172 7537740 16520382 9019162 8663178 9797459 9032244 12577067 9927207 7524086 8995379 9886492 8294403 7559490 9434624 11792427 7798267 8621719 9541596 15688026 12898421 33961781 11370743 25416956 9544989 22974441 8939605 21706016 9083103 7535773 11505033 9175774 24430869 10080542 9020193 9045692 10356320 15888547 9254595 8561895 11707405 8647288
HRAS SOS1 â—¼   PHYSICAL_INTERACTION 989.0 0.99 STRING 36370105
HLA-DRA HLA-DRB1 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
CDC37 HSP90AB1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GAB1 GRB2 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB3 GNG13 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB3 GNG10 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB2 GNG10 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB5 GNG7 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB5 GNG3 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB3 GNG12 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB3 GNG5 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB3 GNG3 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB3 GNG7 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB4 GNG7 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB4 GNG3 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB4 GNG5 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB2 GNG7 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB2 GNG5 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB2 GNGT2 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB2 GNG12 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB2 GNG3 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CTNNA1 CTNNB1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CBL CRKL â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
EGFR SHC1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CDC37 HSP90AA1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CDC42 WAS â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CBL GRB2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CBL EGFR â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CBL PIK3R1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EGFR GRB2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GRB2 SOS1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
AKT1 BAD â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 10722653 10949026 11715018 11756412 11923280 15169778 15808505 16697215 17052453 17680028 18372248 18570873 18636226 20138985 20214616 20398329 20832730 9812896
PRKCE BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20179209 20566643
AKT1 BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 137.0 1.0 Omnipath 10880354 19052636 21506126 20028971 21303971 20214616 11994280 8929531 17570479 12832477 17555943 25241761 11715018 18636226 21998731 9812896 17680028 11500364 18385666 18707149 10201527 18218901 11983683 10490655 19030972 19667065 11756412 11020382 16931767 18372248 15808505 20138985 18046313 18669648 19121340 19703413 11714830 10949026 15972258 16341064 10358075 23085457 18220336 10516287 12897128 9580112 9651683 11923280 9346240 16697215 19690332 11493700 15452053 12040186 10826997 12175651 15722337 14737178 11882383 15226424 10521512 15023346 15784622 17052453 16044149 16403219 12444011 20166139 20398329 9381178 11544290 15037618 12767520 15280015 10230394 10558990 15998799 10082559 11577096 10837486 15169778 10611223 23109003 12954615 22094462 11438654 11312610 11254732 21540285 10383455 19664994 10722653 20832730 18570873 10926925 17270021
AKT2 BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 27.0 1.0 Omnipath 9346240 11493700 20398329 21506126 9381178 15452053 20028971 12040186 21303971 15280015 20214616 10230394 10558990 8929531 10837486 11882383 10611223 12954615 22094462 10949026 11438654 17680028 10516287 18218901 17270021
HSP90AA1 CBL â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 17177598 16187797 15284455 16849543 16969069 16953218 17699773 17372273 17712310
PIK3CD CBL â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9590251 7537740 8995358 9259313
BCAR1 CBL â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 11353765 15169881 15308668 16000375 16076871 18835194 19454690 20189481 22464172
CRKL CBL â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 10426994 11062502 11353765 11385609 11447289 11526404 11579131 11687500 11907067 12670391 15169881 15308668 15536084 16000375 16076871 16713974 17397400 18250477 18287025 18835194 19109239 19454690 19909365 20189481 20805416 21149606 21826665 22464172 23087689 23523669 24751819 24795729 25960930 7682895 9314552
CBL CDC37 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 17177598 16187797 15284455 16849543 16969069 16953218 17699773 17372273 17712310
GRB2 CBL â—¼   PROTEIN_INTERACTION 1.0 1.0 HIPPIE 31980649 8649804 8995445 25036637 23799367 11997436 8943292 9242692 10570290 8662998 11399323 10086340 7642581 9108392 20936779 11133830 8626404 17094785 8063801 9129019 8900205 15210722 8621483 25872741 25814554 9178909 16906159 8950973 17971399 10025673 9295052 19380743 9716598 16713569 11964172 9234717 8083187 7537740 8824292 9259313 9311917 7791764 17072306 14725908 33627783 9461587 9434624 9851874 8695851 12839496 17944804 11792427 10204582 8621719 11823423 9541596 33961781 169092 11263968 98621719 28514442 18273061 7592693 9174058 21706016 8995358 9872323 9233773 9367879 7544353 12941616 10829062 20124286 917890 15677445 9092538 10521482 8647120 19836242
BCAR1 CBL â—¼   SHARES_COMPLEX 9.0 1.0 ACSN 11353765 15169881 15308668 16000375 16076871 18835194 19454690 20189481 22464172
CRKL CBL â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 10426994 11062502 11353765 11385609 11447289 11526404 11579131 11687500 11907067 12670391 15169881 15308668 15536084 16000375 16076871 16713974 17397400 18250477 18287025 18835194 19109239 19454690 19909365 20189481 20805416 21149606 21826665 22464172 23087689 23523669 24751819 24795729 25960930 7682895 9314552
GRB2 CBL â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 10086337 10426994 10567412 10811803 10982827 11447289 11777939 11777960 11907067 12175651 12640133 15536084 15567848 15574420 16339513 16582911 16713974 16887996 17070508 17100878 17496910 17673906 18490724 19449109 26552706 8551221
CRKL CBL â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 10426994 11062502 11353765 11385609 11447289 11526404 11579131 11687500 11907067 12670391 15169881 15308668 15536084 16000375 16076871 16713974 17397400 18250477 18287025 18835194 19109239 19454690 19909365 20189481 20805416 21149606 21826665 22464172 23087689 23523669 24751819 24795729 25960930 7682895 9314552
CBL CD247 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 11353765 15169881 18835194 20189481
CBL VAV1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 11353765 15169881 18835194 20189481
SRC CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 50.0 1.0 Omnipath 9525940 7782294 16713569 18273061 10829062 10799548 10934191 12604776 9890970 17570479 9013636 15135048 17094785 25784557 8635998 10092522 12522270 8621719 17141222 16636290 11239464 19861161 11994282 12941616 14739300 22203672 8849724 15212693
FYN CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 97.0 1.0 Omnipath 9525940 7642581 8626543 7782294 15208330 16503409 16713569 10829062 10799548 10934191 8900205 8551236 8662998 8995358 19734451 12604776 9890970 10592173 17570479 10629042 17094785 10092522 11997497 12522270 15556646 12244174 8621719 9102067 22880054 9311917 11239464 19904769 11994282 12941616 9535867 25814554 12231245 15190072
VAV1 CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 19635790 20940296 16289966 23331499 16356860 11133830 23180781 11331248 12881521 18835194 9200440 16713569 11313921
PRKCA CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10358153 17570479 25814554 11024037
LCK CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 9525940 10829062 10799548 10934191 7721825 16107303 12604776 9890970 17570479 11904433 9178909 10092522 11997497 12522270 8621719 9102067 11239464 11994282 11741956
SYK CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 72.0 1.0 Omnipath 16289966 15922744 9525940 19419964 11133830 33512474 18273061 10829062 10799548 10540342 10934191 7721825 12435267 11331248 12604776 9890970 11042121 10092522 11997497 12522270 9857068 9988765 15556646 11742985 15536084 8621719 9102067 22880054 10551821 11239464 10617633 11994282 10570266 12881521 9535867 15577829
HCK CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 10092522 11994282 9525940 8995358 12604776 9890970 11896602 10799548 11239464 10934191
CBL GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 158.0 1.0 Omnipath 11823423 8621483 9242692 18273061 17635922 16906159 8626404 8662998 9108392 9541596 98621719 9295052 25872741 17372273 8824292 8943292 12941616 20124286 19531499 10086340 8063801 9129019 9590251 11263968 9461587 7642581 10521482 10204582 8995445 8900205 7592693 9716598 8083187 14725908 17904548 7791764 9178909 25036637 8695851 19836242 7537740 15210722 9108316 169092 9311917 10514377 9092538 17072306 19380743 9872323 9234717 11997436 23799367 9434624 16713569 10829062 9367879 11964172 12839496 15677445 9851874 11792427 17094785 20936779 10570290 917890 17944804 25814554 17971399 11133830 8950973 21706016 8995358 9233773 10025673 8621719 11399323 9259313 9174058 8649804
CBL EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 188.0 1.0 Omnipath 34609770 16105874 18273061 22239438 24797263 20332299 17635922 23158001 17545148 8662998 12604776 9890970 23153581 17182860 25872741 12593795 23175185 10092522 15107835 22266821 22833562 24714105 17242169 25140053 20124286 19531499 9756944 10086340 22203672 19225046 16729043 15282549 20562913 22394513 20940296 23331499 7592693 19713535 10635327 19836242 15465819 15210722 25521828 23897813 10514377 12734385 18508924 11994282 20877636 33323455 22976291 23774213 23027125 15159412 18255265 16246327 28541302 16849543 23799367 16713569 10799548 8798643 19155296 9121472 17486068 21772844 16969069 15677445 15962011 23418353 12803489 32714745 14505571 27903975 19578043 26177020 11239464 18319245 11408594 10428778 12061819 17995934 17971399 27059931 26055326 15735736 23457600 7782294 22591401 29629558 11370743 7657591 21071413 28198003 18316398 19947936 9130710 18271526 15657067 31182136 16923119 17880946 32904620 15117950 14627991 15668240 15383614
CBL PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 98.0 1.0 Omnipath 9092574 19190244 16289966 11406619 7642581 11133830 10358153 8941725 9234717 8612729 11157475 10620516 16713569 21203488 11418612 24113870 17635922 18374639 14530346 11526404 8662998 8995358 11030146 9890970 9541596 11042121 15581361 9890943 8080844 7791764 9178909 15107835 8995243 8695807 9988765 23109003 11944898 15556646 17237826 10025673 17722974 8621719 16135792 16107703 16219545 9461587 9160881 9414268 16982329 19861161 10514377 9918857 11087752 9092538 11994282 9259313 15790353 19531499 9174058 8702998 25814554 22315502 19380743 10918571 8896416
CBL PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 9092574 19190244 11406619 11133830 7629144 17635922 11526404 8662998 8995358 8080844 15107835 23109003 17722974 8621719 16107703 9414268 10514377 15790353 19531499 22315502 19380743 25814554 9461587
CBL MET â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 16397241 15123609 23331499 25241761 21222362 11894096 18672314 21163258 19450681 18273061 35309168 17533376 19433454 17635922 10514377
CBL PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 7517397 9712732 12941616 25241761 12061819 23109003 9234717 16503409 11709089 16713569 17372230 16467851 12803489
CBL PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 8641358 9119889 19380743 8621719 7629144 17635922 10514377
CBL LYN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 12149655 18235045 12244174 8627181 8621719 7782294 15304502 9160881 15190072 7721825
PLCG1 CDC37 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 17177598 16187797 15284455 16953218 17712310
SHC1 CDC37 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 16187797 15284455 17646646 16969069 17372273 17712310
GAB1 CDC37 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 17177598 16187797 15284455 16849543 16953218 17646646 15329413 17712310 15118073
CD80 CTLA4 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11964292 12810107 14764699 15197224 17513775 17629517 18585785 20231889 22437870 23390297 25215878 25582338 26405600 7512027 7523569 9359474
CD86 CTLA4 â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10477595 11207245 11964292 14764699 15034038 15197224 17513775 20231889 20805416 21220452 22076556 22437870 23390297 24218453 25215878 25384214 7523569 8920882 9359474
CTLA4 CD28 â—¼   DOWN_REGULATES ✅ - 12.0 1.0 ACSN 10921877 11093160 12370081 16227604 16885030 16916641 18292600 19890961 21159657 21376459 22116087 22437870
FYN CTLA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 9712716 25241761 9813138 9973379 16713569 10842319 10694513
CD80 CTLA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 17145710 21530327 21422170 17953528 22437870 11279501 23954143 11279502 20587542 31757674 7545666 10583602 21982860
LCK CTLA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 9712716 9813138 9398332 9973379 10842319
CD86 CTLA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 17145710 23223433 11162656 9856951 11976720 12582153 11279501 12071705 7694153 7513726 21530327 25241761 22437870 10583602 21982860 23954143 12606712 11021528
CXCL12 CXCR4 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 15261139 15882617 17035340 20535745 20644254 21521526 22025564 23034983 23402812 23567181 24277834
CXCL12 CXCR4 â—¼   PROTEIN_INTERACTION 11.0 1.0 ACSN 15261139 15882617 17035340 20535745 20644254 21521526 22025564 23034983 23402812 23567181 24277834
CXCL12 CXCR4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 24023874 10233851 10699158 11859124 22633458 18648536 18448868 8752280 30476826 12714578 16725153 9712844 8752281 9551924 21757744 19837984 25495026 26582643 16626895
EGFR SHC1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 10404636 20430953 23010081 25987127 28513565
EGFR GRB2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 10404636 20430953 23010081 25987127 28513565
ESR1 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12894229 12421825 8200909 21705183
SRC EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 232.0 1.0 Omnipath 16414009 17081983 25958313 16943190 15618223 19935697 19305428 25402006 24797263 29285309 7488034 15592458 17389395 16461772 20562096 19275932 17897439 15899872 17570479 2803273 23636329 23246962 25505586 23175185 15615697 23349873 16849545 25356505 11983694 24189400 11756413 25748412 26325669 26150526 14512423 18789131 14750954 31978707 25573954 27495374 20071362 18707149 28759036 16729043 26494466 27716204 25537504 17237269 18687633 25884760 29036202 26936397 17575160 20926745 20935677 15282306 23702846 15476828 9069259 19336574 20421302 15660394 23866081 19377510 9777370 22426783 29321659 33706413 25841779 19840943 18669648 12397069 16843263 18957516 34088769 25077442 14963038 19836242 17653080 19625610 16936701 11960379 15548697 18295415 17523611 21268077 20333651 21399647 23376850 11250711 23942551 19704002 22927910 11160627 31952541 10777553 17016520 2543678 19258037 33883672 17646646 28102297 23873690 26771606 21573184 23119029 19151764 16713569 7797556 25955608 15302935 20407013 28513565 23119185 9990038 21080693 20190765 25347738 14630916 15708852 21822308 20628053 25301722 24658140 19690143 27564112 20802523 29124875 33657368 12101233 21787862 14764607 17284441 12878163 26290602 15951569 16543144 15212693 17971399 14523024 10971656 21278788 8845374 22430206 18083107 29641465 18234969 18460189 17551925 22957061 26571308 17043637 20371672 10358079 16799092 19154417 23066441 28065597 12842895 18180459 17158602 18271526 15657067 25159151 34367939 24919575 10075741 25366117 24349301 17561374 16862179 20215522 31980649 24335899 16037379 18451158 14530278 16505275 12063263 23449029 11311660
LYN EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 17145710 31980649 16799092 23866081 24658140 11160627 23764002 25402006 22430206
HCK EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 31980649 24658140 11160627 25402006 23397142
PRKCE EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 33.0 1.0 Omnipath 11447289 21749319 8321321 11313945 12359306 25402006 12040186 23830194 6321473 1860884 27016036 6090944 19568798 14585353 17496910 21386996 17942932 20692258 24658140 1556153 2984676 18042729 11940581 11185568 19615955 2987962 23205726 12845332 10816576 3379075 15567848 16488589 16793002
PRKCB EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 17496910 11940581 21386996 11447289 19615955 16488589 6321473 8321321 12845332 11313945 7805884 17570479 12040186 19568798 15567848 14585353
TGFB1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20953304 32103204 19132220 28943431
ICAM1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16799092 17145710
FGR EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 31980649 24658140 11160627 25402006
PRKCA EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 39.0 1.0 Omnipath 11447289 8321321 11313945 25402006 12040186 20888375 15302935 6321473 1860884 12878187 6090944 19568798 14585353 17496910 21386996 24658140 2984676 11940581 31980649 15212693 85012702 19615955 2987962 12845332 3379075 7805884 10816576 15567848 16488589
EGFR GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 46.0 1.0 Omnipath 19901323 15231819 16497976 25402006 17389395 20068231 23066441 11432805 9658397 19509291 18669648 10978177 10753869 10734310 11896055 18271526 24658140 10648629 11779868 31980649 15212693 9890893 17016520
EGFR CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 32.0 1.0 Omnipath 19104148 27401557 15371335 16099633 22558232 30747223 12040186 26509276 24816560 12740122 25500543 17318191 19568798 21423209 14585353 34227224 23640056 17496910 17052462 24240237 25164010 14517306 21903109 22200182 16952352 20858269 28035485 9233779
EGFR PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 89.0 1.0 Omnipath 19901323 17081983 16273093 9207933 2472219 16497976 15592455 16126727 16713569 24797263 17389395 8578591 23331499 7991458 1689310 20068231 17570479 9176240 12803489 16153436 7993895 16038803 7805859 15864276 1708307 7682059 15144186 11983899 12601080 9756944 15212693 14568990 12061819 9020117 8885868 12648464 8657103 15951569 17016520 7693694
EGFR CRKL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 31980649 23397142 18271526 24658140 25402006 16729043
EGFR GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 109.0 1.0 Omnipath 9544989 10595738 23956138 27059931 10026169 16273093 11726515 24697349 21596750 19289468 7518560 21706016 23799367 9050991 16317285 16713569 25402006 11370743 24797263 8647858 8887653 9416834 21278786 16799092 8662998 10229072 11896612 7592693 19509291 8810325 24189400 19836242 11960376 7506413 18271526 15657067 10085134 24658140 17242169 7510700 8940013 7650032 8810340 11084343 12577067 7527043 31980649 11408594 19531499 20124286 23178716 9886492 23181695 9020117 8479540 14679214 12648464 1322798 17991782 16729043 17971399
EGFR PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 17496910 31980649 23956138 19531499 16273093 24658140 11172806 1334406 25402006
EGFR ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 20809984 17284441 16713569 11887937
EGFR PLCG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 31980649 25241761 16273093 24658140 17570479 25402006
EGFR EZR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 1382070 31980649 24658140 12560083 9230083 15212693 10377409 15647376
EGFR SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 78.0 1.0 Omnipath 9544989 8808684 10595738 23956138 9388490 11350724 16273093 7542991 7681824 7518560 9710588 23799367 16713569 25402006 11370743 24797263 9742218 20935677 8887653 8034616 23331499 8662998 7542744 10049786 28065597 9130710 10635327 24189400 7506413 18271526 15657067 24658140 8810340 12577067 11196191 10766863 23178716 31980649 35384245 11408594 19531499 9756944 26551075 1623525 15951569 16729043 17956904
EGFR VAV2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 17389395 19531499 11516622 26910843 10938113 10618391 12577067 12454019 17016520
EGFR PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 17496910 31980649 25241761 16273093 24658140 25402006
EGFR SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9544989 19531499 9447973 16713569 12577067
EGFR PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 17496910 26918608 7797556 25241761 19531499 16273093 8662998 14967450 16713569 21701776
EGFR VAV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 16273093 10938113 24658140 25402006
AKT1 FOXO3 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11154281 11715018 11923280 15169778 17680028 20214616 20398329
FOXO3 AKT1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 15987244 10358075 10102273 12857750
FOXO3 FASLG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11756562 20051626 15895074 20371612 10102273 14701673 20671123 19690465
FOXO3 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 24062311 16807346 16809346 17575143
FOXO3 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19424579 23517348 21752881 22539004 11278373
AKT2 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 19951971 19216069 17680028 11756412 17646672 20214616 11463845 20452955 9829964 20398329 10102273 18593906 16680151 10217147 19188143
CTNNB1 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 15905404 21071413 17254970
AKT1 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 64.0 1.0 Omnipath 19951971 11756412 11953455 11923280 20452955 21798082 20398329 21329882 10217147 11154281 11994454 23331499 10995739 19216069 20214616 11463845 21775285 20068231 9829964 17570479 10102273 18593906 17646672 16680151 18988627 21621563 15169778 17522590 25241761 23109003 11715018 19188143 15023346 17680028 26192618 11864996
FOXO3 PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 18644865 10783894 16288288 20673124 11094066 17646672 15509806 11994454 11154281
FOXO3 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 18644865 10783894 16288288 20673124 11094066 17646672 15509806 11994454 11154281
FOXO3 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11435445 15367686 16807346 18312651
FOXO3 FASLG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 14976264 18644865 10783894 16288288 20673124 11094066 10102273 17646672 16865280 15509806 11994454 11154281
WAS GRB2 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 11340081 11829459 10878810 12213210 11553796 10781580 11157975
SYK GRB2 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 12456653 9341187 9705962 19372136 11071869 11449366 11909947 9697839 21822214
FGFR1 GRB2 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 17505008 18757403 21666749 11689702 11739186 18381441 19809159 21160078 14534538 15448205
GRB2 GAB1 â—¼   PHYSICAL_INTERACTION 50.0 1.0 ACSN 10086337 10514377 10567412 10648629 10811803 10982827 11062502 11313945 11385609 11447289 11777939 11907067 11940581 12040186 12175651 12419216 12640133 12670391 12782630 14585353 15199124 15534002 15536084 15567848 15574420 15584861 15863030 16102570 16227978 16488589 16582911 16847462 16887996 17496910 17635922 17673906 18287025 19449109 19568798 19615955 20805416 21102635 23523669 24027568 26552706 27111285 7510700 8294866 8551221 9779982
GRB2 SYK â—¼   PHYSICAL_INTERACTION 71.0 1.0 ACSN 10022831 10086337 10358164 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11907067 11960372 12175651 12393695 12524384 12629515 12640133 13678960 14568985 15099563 15111329 15501236 15520864 15536084 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17101731 17496910 17673906 17883421 19414323 19449109 19909365 20150200015 21149606 21372296 21378271 21910624 22064427 22461508 23390297 23609447 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8189062 8226994 8551221 8837607 9000133 9157999 9295024 9314552 9396765 9570538 9632805 9753319 9763615
GRB2 CRKL â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
GRB2 BRAF â—¼   PHYSICAL_INTERACTION 48.0 1.0 ACSN 10086337 10567412 10811803 10843677 10982827 11023813 11034387 11062502 11385609 11447289 11777939 11907067 12040186 12175651 12419216 12640133 12782630 14585353 14764585 15169888 15536084 15547943 15567848 15574420 15735649 15863030 16102570 16227978 16488589 16582911 16887996 17178906 17395718 17496910 17613518 17673906 19449109 19541618 19565474 19568798 19615955 21102635 22435554 24027568 26552706 7510700 8551221 9510155
GRB2 LAT â—¼   PHYSICAL_INTERACTION 51.0 1.0 ACSN 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483
GRB2 CD28 â—¼   PHYSICAL_INTERACTION 23.0 1.0 ACSN 10086337 10209041 10567412 10811803 10982827 11447289 11777939 12175651 12640133 1313950 15197224 15567848 15574420 16582911 16887996 17496910 17673906 19449109 22437870 26552706 7523569 8551221 9359474
GRB2 PLCG1 â—¼   PHYSICAL_INTERACTION 51.0 1.0 ACSN 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483
GRB2 SHC1 â—¼   PHYSICAL_INTERACTION 69.0 1.0 ACSN 10022831 10086337 10358164 10567412 10811803 10849428 10982827 11166270 11283723 11335727 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15308668 15501236 15520864 15567848 15573129 15574420 15863030 16000375 16002046 16076871 16102570 16212621 16530705 16572188 16582911 16887996 17086423 17496910 17673906 17883421 18835194 19223473 19414323 19449109 19454690 19909365 21372296 21378271 22064427 22461508 22464172 23390297 23896411 24027568 24217602 24346288 24670066 25922287 26201938 26552706 7510700 8551221 8837607 9157999 9570538 9753319 9763606
SOS1 GRB2 â—¼   PROTEIN_INTERACTION 1.0 1.0 HIPPIE 28514442 16520382 31980649 32062451 8493579 21988832 14679214 7510700 7514169 21706016 10319320 32203420 9872323 9797459 34407391 16906159 10716926 12577067 8810325 7629168 11960376 7664271 8626525 15192046 7629138 11997436 8943292 10207103 8695800 10570290 10025673 8112292 11726515 8816480 20473329 7559490 7773779 9447984 19380743 7642581 7527391 9716598 9344843 10477741 16713569 19323566 7516467 17474147 9569023 8188688 16893902 11964172 9478994 33961781 8479541 28166272 9009162
GRB2 LAT â—¼   PROTEIN_INTERACTION 51.0 1.0 ACSN 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483
GRB2 SHC1 â—¼   PROTEIN_INTERACTION 69.0 1.0 ACSN 10022831 10086337 10358164 10567412 10811803 10849428 10982827 11166270 11283723 11335727 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15308668 15501236 15520864 15567848 15573129 15574420 15863030 16000375 16002046 16076871 16102570 16212621 16530705 16572188 16582911 16887996 17086423 17496910 17673906 17883421 18835194 19223473 19414323 19449109 19454690 19909365 21372296 21378271 22064427 22461508 22464172 23390297 23896411 24027568 24217602 24346288 24670066 25922287 26201938 26552706 7510700 8551221 8837607 9157999 9570538 9753319 9763606
GRB2 PLCG1 â—¼   SHARES_COMPLEX 51.0 1.0 ACSN 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483
GRB2 SYK â—¼   SHARES_COMPLEX 71.0 1.0 ACSN 10022831 10086337 10358164 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11907067 11960372 12175651 12393695 12524384 12629515 12640133 13678960 14568985 15099563 15111329 15501236 15520864 15536084 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17101731 17496910 17673906 17883421 19414323 19449109 19909365 20150200015 21149606 21372296 21378271 21910624 22064427 22461508 23390297 23609447 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8189062 8226994 8551221 8837607 9000133 9157999 9295024 9314552 9396765 9570538 9632805 9753319 9763615
GRB2 GAB1 â—¼   SHARES_COMPLEX 50.0 1.0 ACSN 10086337 10514377 10567412 10648629 10811803 10982827 11062502 11313945 11385609 11447289 11777939 11907067 11940581 12040186 12175651 12419216 12640133 12670391 12782630 14585353 15199124 15534002 15536084 15567848 15574420 15584861 15863030 16102570 16227978 16488589 16582911 16847462 16887996 17496910 17635922 17673906 18287025 19449109 19568798 19615955 20805416 21102635 23523669 24027568 26552706 27111285 7510700 8294866 8551221 9779982
GRB2 CD28 â—¼   SHARES_COMPLEX 23.0 1.0 ACSN 10086337 10209041 10567412 10811803 10982827 11447289 11777939 12175651 12640133 1313950 15197224 15567848 15574420 16582911 16887996 17496910 17673906 19449109 22437870 26552706 7523569 8551221 9359474
GRB2 CRKL â—¼   SHARES_COMPLEX 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
GRB2 BRAF â—¼   SHARES_COMPLEX 48.0 1.0 ACSN 10086337 10567412 10811803 10843677 10982827 11023813 11034387 11062502 11385609 11447289 11777939 11907067 12040186 12175651 12419216 12640133 12782630 14585353 14764585 15169888 15536084 15547943 15567848 15574420 15735649 15863030 16102570 16227978 16488589 16582911 16887996 17178906 17395718 17496910 17613518 17673906 19449109 19541618 19565474 19568798 19615955 21102635 22435554 24027568 26552706 7510700 8551221 9510155
FYN GRB2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 9822663 15886116 10849438 12670394
HRAS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
ITK GRB2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 11406363 12186560 15661896 25137453
FOS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11274345 12738796 15067049 16393692 16394015 18039929 19667062 21385848 22634314 23430059 9064320
LCK GRB2 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10652356 11062502 12731048 12740575 15536084 17544292 19290918 20814939 21127503 22513334 23620508 8478617 8986721 9438848 9738502 9751747
CD247 GRB2 â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 10562324 10925299 11353765 11438547 11875494 12415267 12731048 12811837 15735648 16713974 17371980 20435894 20814939 21059766 23414611 23508573 23620508 23886063 24378531 7600293 8478617 8642247 9625766 9738502
GRB2 PLCG2 â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10072481 10086337 10567412 10781611 10811803 10982827 11169415 11447289 11777939 12175651 12640133 14764585 15567848 15574420 16102570 16329184 16582911 16887996 17496910 17673906 19449109 19494291 19909365 23620508 25137453 26552706 7523143 7890616 8551221 8649391 8976179 9489702 9535722
GRB2 SYK â—¼   ENZYMATIC_REACTION ✅ 71.0 1.0 ACSN 10022831 10086337 10358164 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11907067 11960372 12175651 12393695 12524384 12629515 12640133 13678960 14568985 15099563 15111329 15501236 15520864 15536084 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17101731 17496910 17673906 17883421 19414323 19449109 19909365 20150200015 21149606 21372296 21378271 21910624 22064427 22461508 23390297 23609447 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8189062 8226994 8551221 8837607 9000133 9157999 9295024 9314552 9396765 9570538 9632805 9753319 9763615
GRB2 VAV1 â—¼   ENZYMATIC_REACTION ✅ 57.0 1.0 ACSN 10077632 10086337 10426994 10567412 10646608 10679059 10714681 10811803 10849438 10898494 10982827 11080163 11447289 11526404 11698448 11754814 11777939 11777960 11907067 11994416 12094222 12165654 12175651 12186560 12616499 12626562 12640133 12740575 12885870 12917349 14764585 15169881 15536084 15567848 15574420 16339513 16582911 16713974 16887996 17070508 17100878 17496910 17673906 18490724 19449109 19909365 20189481 22513334 22786724 22952938 25355530 25539813 26552706 8189062 8226994 8551221 9438848
GRB2 SHC1 â—¼   ENZYMATIC_REACTION ✅ 69.0 1.0 ACSN 10022831 10086337 10358164 10567412 10811803 10849428 10982827 11166270 11283723 11335727 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15308668 15501236 15520864 15567848 15573129 15574420 15863030 16000375 16002046 16076871 16102570 16212621 16530705 16572188 16582911 16887996 17086423 17496910 17673906 17883421 18835194 19223473 19414323 19449109 19454690 19909365 21372296 21378271 22064427 22461508 22464172 23390297 23896411 24027568 24217602 24346288 24670066 25922287 26201938 26552706 7510700 8551221 8837607 9157999 9570538 9753319 9763606
GRB2 PIK3R1 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
GRB2 PLCG1 â—¼   ENZYMATIC_REACTION ✅ 51.0 1.0 ACSN 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483
GRB2 LAT â—¼   ENZYMATIC_REACTION ✅ 51.0 1.0 ACSN 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483
GRB2 CXCL8 â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11283723 11447289 11449354 11777939 12175651 12393695 12640133 15520864 15567848 15574420 16076871 16582911 16887996 17496910 17673906 19223473 19449109 26552706 8551221
GRB2 ITGA4 â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 10086337 10426994 10567412 10811803 10982827 11447289 11777939 11777960 11907067 12175651 12640133 15536084 15567848 15574420 16339513 16582911 16713974 16887996 17070508 17100878 17496910 17673906 18490724 19449109 26552706 8551221
GRB2 ITGB1 â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 10086337 10426994 10567412 10811803 10982827 11447289 11777939 11777960 11907067 12175651 12640133 15536084 15567848 15574420 16339513 16582911 16713974 16887996 17070508 17100878 17496910 17673906 18490724 19449109 26552706 8551221
GRB2 GAB1 â—¼   ENZYMATIC_REACTION ✅ 50.0 1.0 ACSN 10086337 10514377 10567412 10648629 10811803 10982827 11062502 11313945 11385609 11447289 11777939 11907067 11940581 12040186 12175651 12419216 12640133 12670391 12782630 14585353 15199124 15534002 15536084 15567848 15574420 15584861 15863030 16102570 16227978 16488589 16582911 16847462 16887996 17496910 17635922 17673906 18287025 19449109 19568798 19615955 20805416 21102635 23523669 24027568 26552706 27111285 7510700 8294866 8551221 9779982
GRB2 LCP2 â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 10086337 10426994 10567412 10811803 10982827 11447289 11777939 11777960 11907067 12175651 12640133 15536084 15567848 15574420 16339513 16582911 16713974 16887996 17070508 17100878 17496910 17673906 18490724 19449109 26552706 8551221
GRB2 FYN â—¼   DOWN_REGULATES ✅ - 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
BTK GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20936779 19380743
SHC1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 198.0 1.0 Omnipath 8808684 9083103 8551221 9126968 8621483 25416956 9252386 8524223 7535773 8662998 11302736 11827484 8995379 9541596 9175774 10207047 7717978 17673906 7744881 11505033 10523831 24189400 9927207 7650032 8810340 9045692 23178716 19531499 15812354 9129019 10356320 12485888 9461587 8114695 7514169 9566877 8939605 16371368 15341520 7529871 10891441 10749687 7524086 26645482 8491186 10592173 10049786 9171350 11707404 7537740 15688026 8663178 19380743 11782427 9544989 16436051 9434624 16713569 21725358 11964172 17314098 11792427 8195171 1465135 12213123 8647288 12955078 10477741 11707405 12577067 9199344 10080542 8112292 7760801 10570290 11997181 7798267 16520382 10961885 8950973 21706016 9448048 8662733 11370743 8051109 9733714 8621475 9254595 8294403 10748054 8621719 8940013 12441060 22057045 7505797 24737791 20697350 9886492 18174162 18273058 8235613 7963520 7523859
MET GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9660480 15546961 22128289 12475979 11063574 7511210 11439336 8662889
CD28 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 18829987 8576157 9694876 24098653 27927989 21487479 7737275
LAT GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 11368773 9489702 10811803 8063801 17043143 16938345 16713569 23150273 12186560 16906159
SYK GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11964172 16189514 22267732 10747947
LCP2 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 7706237 20936779 10224278 8695800 17235283 15929943 25416956 19380743 9716598 32296183 10204582 11314042 8995445
SRC GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 12624098 11964172 9016807 16713569 26103942 20554525
VAV1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 8900182 10207103 9013873 15558030 7651724 7809090 8621483 29997244 18692475 7478592 16713569 11406576 9209406 16339550
GRB2 GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 47.0 1.0 Omnipath 12766170 21706016 9242692 10913131 11445578 22536782 8596638 11027663 10592173 20936779 11960376 15010462 19523899 20005866 19380743 10871282 9804835 14685170 11314042
GRB2 VAV2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17145710 19531499 7809090 11606575 12577067
GRB2 KHDRBS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 10467411 20936779 21988832 7537265 9872323 8576157 11960376 11278465 9045636 21706016 16713569 12112020 7799925
GRB2 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 145.0 1.0 Omnipath 9544989 9872323 7642581 15746962 11726515 8621483 23334917 16520382 11997436 21706016 10359574 8950973 7664271 16713569 16893902 16906159 21988832 19323566 9009162 10716926 11964172 7629168 9815779 10592173 9716598 8647802 28166272 7773778 7773779 18778683 8188688 10319320 8810325 9344843 23452850 11960376 8816480 10025673 7510700 8940013 12955078 9697839 12345678 10477741 8493579 8943292 12577067 7862167 9199344 8112292 7898932 10207103 8695800 19531499 10570290 7760801 20005866 19380743 9447984 8235613 8479540 7527391 14679214 8479541 17474147 7514169 7629138
GRB2 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9281317 15953601 7629168 9020117 16713569 10940929
GRB2 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17496910 16713569 17673906 11352655
SRC HNRNPK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 7516469 17178840 24642125 12052863 7592945 16854432 16713569 21184736
HNRNPK KHDRBS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 21988832 22365833 31413325 16713569 12370808
HSP90AA1 GAB1 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 17177598 16187797 15284455 16849543 16953218 17646646 15329413 17712310 15118073
HSP90AA1 SHC1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 16187797 15284455 17646646 16969069 17372273 17712310
HSP90AA1 PLCG1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 17177598 16187797 15284455 16953218 17712310
HSP90AA1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 19356729 18266962 10995457 25714412 16189514 12176997 12586360 15843522
HSP90AA1 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 1310678 16844778 16189514 18266962
VAV1 ICAM1 â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10077632 10646608 10679059 10714681 10849438 10898494 11080163 11526404 11698448 11754814 11994416 12094222 12165654 12186560 12616499 12626562 12740575 12885870 12917349 14764585 15169881 16887996 19909365 20189481 22513334 22786724 22952938 25355530 25539813 26552706 8189062 8226994 9438848
IFNG ICAM1 â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 10485906 11489965 11579131 11777960 11870632 11964313 12413632 12818165 14607900 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 1825141 18272812 19833085 20038811 20819927 21149606 21411734 24658051 26755705 2965306 6425450 9834059 9864217
ICAM1 ITGAL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 11786177 16595626 16354667 12526797 23602662 11279101 16189514 14507735
CSF2 IKBKG â—¼   ENZYMATIC_REACTION ✅ 21.0 1.0 ACSN 10426994 11015446 11280761 11460167 11777960 11907067 12193690 12907458 14660645 15536084 16713974 17301840 18264787 20805416 21133840 21232017 21765015 22869907 24030977 24699077 24958845
TNF IKBKG â—¼   ENZYMATIC_REACTION ✅ 84.0 1.0 ACSN 10542212 10754326 10820262 10925299 10952726 11112697 11274345 11280761 11438547 11460167 11875494 12133805 12433365 12646658 12811837 12907458 1431106 14607933 14625680 14660645 15099563 15199157 15465827 15485931 15536066 15592525 15644117 15699106 15749903 16243976 16413922 16713974 16818229 16878026 16970925 17237376 17254973 17301840 17363905 17404308 17462996 17485448 17693255 17916596 18264787 18345002 18633355 18641653 18716620 19392652 19411070 20038811 20138012 20184663 20300203 20435894 21133840 21217011 21232017 21411734 21807870 21826665 22435554 22955274 23086447 23170255 23390297 23422957 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 2649237 28462531 7594497 8910423 9743347
IL2 IKBKG â—¼   ENZYMATIC_REACTION ✅ 21.0 1.0 ACSN 10807786 11280761 11460167 14660645 15289500 15563472 17301840 1825141 18264787 18758473 19528259 21133840 21232017 22224781 23650441 24699077 24958845 26755705 2965306 6164929 9625766
CARD11 IKBKG â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 11280761 11356195 11460167 12356734 14660645 16809782 16818229 17052756 17301840 17363905 17462996 17948050 18264101 18264787 20685844 21133840 21199863 21232017 21873235 24560716 24699077 24958845
IKBKG BCL10 â—¼   ENZYMATIC_REACTION ✅ 44.0 1.0 ACSN 11280761 11356195 11460167 12133805 12356734 14660645 15145317 15199157 15485931 15536066 16809782 16818229 16970925 17052756 17237376 17254973 17301840 17363905 17462996 17485448 17693255 17948050 18264101 18264787 18716620 19302050 20138012 20300203 20685844 21133840 21199863 21217011 21232017 21807870 21873235 22435554 23086447 23422957 23430059 24560716 24699077 24958845 2649237 28462531
TNF IKBKG â—¼   DOWN_REGULATES ✅ - 84.0 1.0 ACSN 10542212 10754326 10820262 10925299 10952726 11112697 11274345 11280761 11438547 11460167 11875494 12133805 12433365 12646658 12811837 12907458 1431106 14607933 14625680 14660645 15099563 15199157 15465827 15485931 15536066 15592525 15644117 15699106 15749903 16243976 16413922 16713974 16818229 16878026 16970925 17237376 17254973 17301840 17363905 17404308 17462996 17485448 17693255 17916596 18264787 18345002 18633355 18641653 18716620 19392652 19411070 20038811 20138012 20184663 20300203 20435894 21133840 21217011 21232017 21411734 21807870 21826665 22435554 22955274 23086447 23170255 23390297 23422957 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 2649237 28462531 7594497 8910423 9743347
AKT1 IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20837477 20098747 17660512
BCL10 IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 14695475 19897484 18287044 27070702 17363905
ITGB1 LYN â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 12626562 19161977 19454690 19487819 22470492 9003039 9456329 9763606 9973479
ITGA4 LYN â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 12626562 19161977 19454690 19487819 22470492 9003039 9456329 9763606 9973479
LYN FCER1G â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 12524384 19909365 21910624 24445665 26552706 8064233 8132624 8478617 8892616
LYN CD247 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 12524384 19909365 21910624 24445665 26552706 8064233 8132624 8478617 8892616
CSK LYN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 38.0 1.0 Omnipath 19901323 11489946 15626731 10415030 16497976 14967142 16537894 7935444 20068231 18452278 10592173 18669648 9171348 18691976 8612628 8794770 19651622 22711887 1722201
LYN SYK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 9820500 24129562 10022120 18818202 21469132 24607955 18083107 17389395 19285079 11536198 10592173 25045209 7797565 11380624 9857068 7513017 30923129 8621719 10477689 7831290 15701717 27258042 19369195 28082678 8666899 9535867 8657103 14871838
LYN PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21780115 15032589 11526404 23109003 22880054 10488096
LYN PLCG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 19901323 8395016 12181444 11606584 14656219 7682059 15144186 10469124 11507089 16497976 10981967 15212693
LYN BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 9581808 9020138 10428862
LYN PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 21780115 29145629 12506011 18453587 11526404 10455108 15032589 23109003 23180781 9334184 15149544 10194437 22880054 11598010 10488096
LYN SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23109003 7650013 7516469 10329689
LYN MS4A2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 7528770 7612892 19356729 22845063
LYN DOK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11071635 11489946 16537894 11841937 11825908
LYN PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 45.0 1.0 Omnipath 17389395 12601080 8395016 16038803 10586033 1689310 20068231 1708307 7682059 8885868 15144186 16497976 8657103 15592455 16126727 17016520 16153436
LYN BTK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 18083107 8629002 12573241 11598012 19369195 10051622 9012831 8630736 9730885 10811866 9052864 8058772 11226282
PIK3CA PIK3R1 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
SHC1 PIK3R1 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
CRKL PIK3R1 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
HRAS PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9069260 25241761 10212255 11313862 9150145 16713569 15021914
LAT PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11368773 9489702 19132916 23109003 16713569 14696041
MET PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17496910 15735664 7513258
ICOS PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16217039 27135603 18641334
FGR PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21780115 15032589 11526404 23109003 22880054 10488096
CD3E PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9312149 11855827 11689561
CDC42 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 7629060 8034624 9381982
CTNNB1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10477752 25241761 16219695 11716761
HCK PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17145710 21780115 11526404 15032589 23109003 12029088 22880054 10488096
GAB1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 17145710 10978177 11940581 8596638 24728074 9891995 16638574 9658397 9804835 11606067 9632795
LCK PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 8294442 11337495 8246987 14583609 11526404 15032589 23109003 9461588 7504174 8397196 10488096
SHC1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 19531499 8662998 7537361 19380743 8621719 16135792 9541596 16219545 16713569 23397142 19889638
SYK PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16921024 15536084
FYN PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 8294442 8394019 7515100 17570479 16713569 7520528 1652056
ESR1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11029009 11689445 16169518 23065768 16713569
CRKL PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9092574 16135792 11418612 23397142 9461587 16982329
FGFR1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17496910 18412956 25241761 15117958
PIK3R1 FASLG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11741599 25241761 19807924
PIK3R1 CDC42 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 7629060 8034624 9381982
PIK3R1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10527852 16799564 19442713
PIK3R1 PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 8596638 25241761 20713702 27107012 11733063 21825134 32814053 26496610 8139559 14729945 10358930 14665640
PIK3R1 PLCG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17474147 25241761
PIK3R1 PIK3CD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9113989 8596638 21827948 12147247 11733063 22020336 24165795 31031754 14665640
PIK3R1 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17474147 19531499 25241761
AKT1 SFN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 20138985 15169778 9812896 17680028 11756412 11923280 20214616 16697215 10949026 10722653 20832730 18570873 18372248 11715018 20398329 17052453 18636226 15808505
FCER1G TNF â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 12731048 15081523 15099567 20814939 23414611 2451784 7590867 9625766 9952373
TNF CXCL1 â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10925299 11112697 11438547 11875494 12646658 12811837 1431106 14607933 14625680 15099563 15699106 16713974 17916596 18633355 19411070 20038811 20184663 20435894 21133840 21411734 21826665 22595692 22955274 23170255 23430059 23508573 23510023 23567181 23769623 24092389 24378531 26201938 8910423
ESR1 TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23733894 15334655 16483936 12237295 20664923
FOS TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 19285436 2506186 16834785 22322974 10837498 12057991 9030359 25567680 19026727
SRC VAV3 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17686471 8986718 11007481 10395673 9099726
CD247 VAV3 â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 10562324 10925299 11353765 11438547 11875494 12415267 12731048 12811837 15735648 16713974 17371980 20435894 20814939 21059766 23414611 23508573 23620508 23886063 24378531 7600293 8478617 8642247 9625766 9738502
PLCG1 VAV3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11094073 10592173
SRC VAV3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17998938 11917103
LCP2 VAV3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15708849 14757747
CD247 FCER1G â—¼   PHYSICAL_INTERACTION 39.0 1.0 ACSN 10358164 10562324 10925299 11353765 11385609 11438547 11449354 11489965 11513144 11875494 11994457 12055234 12393695 12731048 12811837 15081523 15099567 15778339 16287995 16713974 17100877 18768831 20435894 20814939 21059766 2139103 22267813 23414611 23508573 24378531 24445665 7523143 8344348 8478617 8551221 9603467 9625766 9738502 9751747
CD247 FCER1G â—¼   SHARES_COMPLEX 39.0 1.0 ACSN 10358164 10562324 10925299 11353765 11385609 11438547 11449354 11489965 11513144 11875494 11994457 12055234 12393695 12731048 12811837 15081523 15099567 15778339 16287995 16713974 17100877 18768831 20435894 20814939 21059766 2139103 22267813 23414611 23508573 24378531 24445665 7523143 8344348 8478617 8551221 9603467 9625766 9738502 9751747
FYN FCER1G â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10591186 10648627 11062502 12218089 12731048 15536084 19290918 19909365 20814939 21378271 22683124 22863785 24440149 27192565 9738502
LCK FCER1G â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10652356 11062502 12731048 12740575 15536084 17544292 19290918 20814939 21127503 22513334 23620508 8478617 8986721 9438848 9738502 9751747
HCK FCER1G â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 12524384 21910624 24445665 8064233 8132624 8478617
FCER1G IFNG â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10925299 11438547 11489965 11513144 11875494 11994457 12055234 12811837 15081523 15778339 16287995 16713974 17100877 20435894 23414611 23508573 24378531 9625766 9751747
FCER1G SYK â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 12731048 15081523 15099567 20814939 23414611 2451784 7590867 9625766 9952373
FCER1G SHC1 â—¼   ENZYMATIC_REACTION ✅ 21.0 1.0 ACSN 10358164 10562324 11353765 11449354 12393695 12731048 15081523 15099567 18768831 20814939 21059766 2139103 23414611 24445665 7523143 8344348 8478617 8551221 9603467 9625766 9738502
CD247 FCER1G â—¼   DOWN_REGULATES ✅ - 39.0 1.0 ACSN 10358164 10562324 10925299 11353765 11385609 11438547 11449354 11489965 11513144 11875494 11994457 12055234 12393695 12731048 12811837 15081523 15099567 15778339 16287995 16713974 17100877 18768831 20435894 20814939 21059766 2139103 22267813 23414611 23508573 24378531 24445665 7523143 8344348 8478617 8551221 9603467 9625766 9738502 9751747
FCER1G SYK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9280292 17145710 8071371 8810294 8663460
CCL7 CCR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 14991608 12381680 9115216 10699158 11994538 7545673 22633458 9336350 8530354
CCL7 CCR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 8642344 10733106 10699158 22633458
CCL7 CCR5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 10477718 16298345 10699158 22633458 10477710
CCL7 CCR10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10706668 9364936
CXCL8 CXCR1 â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 15079071 17533374 17784835 17916596 18555778 18633355 18980965 21328342 21847358 24406209 25922287 26201938 26548401 27557510
CXCL8 CXCR1 â—¼   PROTEIN_INTERACTION 14.0 1.0 ACSN 15079071 17533374 17784835 17916596 18555778 18633355 18980965 21328342 21847358 24406209 25922287 26201938 26548401 27557510
CXCL6 CXCR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 8702798 10699158 9485196 16189514 9692902 22633458 12964882 10593335
CXCL8 CXCR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 56.0 1.0 Omnipath 8702798 8137938 9195914 10699158 1840701 12628493 10188995 15946947 22262769 8550564 9553055 1379593 8662882 8245475 10368283 9485196 8940121 15282370 11350788 9725262 10206993
CXCL1 CXCR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 8702798 9195914 10699158 16189514 1379593 12964882
CXCL3 CXCR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 129648828702798 8702798 16189514 12964882
CSF2 CXCL1 â—¼   ENZYMATIC_REACTION ✅ 21.0 1.0 ACSN 10426994 11015446 11280761 11460167 11777960 11907067 12193690 12907458 14660645 15536084 16713974 17301840 18264787 20805416 21133840 21232017 21765015 22869907 24030977 24699077 24958845
CXCL1 CXCR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 7592830 8702798 9195914 10699158 12628493 22633458 10188995 12549928 8550564 28389721 16189514 1379593 8662882 9126332 10216072 24218476 8940121
MET CRKL â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 10871282 12138161 11146548 10753869 10618718
SHC1 CRKL â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
CRKL BCAR1 â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 10426994 11062502 11353765 11385609 11447289 11526404 11579131 11687500 11907067 12670391 15169881 15308668 15536084 16000375 16076871 16713974 17397400 18250477 18287025 18835194 19109239 19454690 19909365 20189481 20805416 21149606 21826665 22464172 23087689 23523669 24751819 24795729 25960930 7682895 9314552
SHC1 CRKL â—¼   SHARES_COMPLEX 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
CRKL BCAR1 â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 10426994 11062502 11353765 11385609 11447289 11526404 11579131 11687500 11907067 12670391 15169881 15308668 15536084 16000375 16076871 16713974 17397400 18250477 18287025 18835194 19109239 19454690 19909365 20189481 20805416 21149606 21826665 22464172 23087689 23523669 24751819 24795729 25960930 7682895 9314552
FYN CRKL â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10591186 10648627 11062502 12218089 12731048 15536084 19290918 19909365 20814939 21378271 22683124 22863785 24440149 27192565 9738502
CRKL BCAR1 â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 10426994 11062502 11353765 11385609 11447289 11526404 11579131 11687500 11907067 12670391 15169881 15308668 15536084 16000375 16076871 16713974 17397400 18250477 18287025 18835194 19109239 19454690 19909365 20189481 20805416 21149606 21826665 22464172 23087689 23523669 24751819 24795729 25960930 7682895 9314552
BCAR1 CRKL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 8978305 9498705 18835194 10592173 8810278 10753828 12345678 8943292 23770091
GAB1 CRKL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 10753869 25241761 24728074 31585087 10871282 10592173 23397142
CRKL PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9092574 9461587 11553620
CRKL GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 10753869 25241761 24728074 31585087 10871282 10592173 23397142
CRKL BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 8978305 9498705 18835194 10592173 8810278 10753828 12345678 8943292 23770091
CCR5 GNAI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520 15251452
CXCR4 GNAI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520
ARRB1 GNAI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520
ARRB2 GNAI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520
GNAI3 ADCY5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 23109003 15539636 7935349 16460834 11376933 8327893
CDC42 ACTG1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 24914801 15507212 16439214 22608513
CCL3 CCR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 47.0 1.0 Omnipath 11170631 10734056 10488147 10699158 7545673 10202040 22633458 10498628 9169459 9336350 10910894 8530354 23765404 9687537 9207005 20219869 9115216 9624164 10660125 7622448 12381680
CCL3 CCR4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8573157
CCL3 CCR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 24218476 7594543 7622448
CCL3 CCR5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 11170631 16298345 10477718 23765404 15075201 9468473 20219869 9169459 11700073 10699158 9334377 9790730 22633458 12964882
CCL21 CCR7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 11970971 10488147 9507024 10699158 16713569 22633458 22221265 9585422
CXCL9 CCR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 11110785 22633458
CCL19 CCR10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10706668
CCL19 CCR7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 10512740 9507024 15546958 10699158 9153236 24218476 22633458 11342595 16904643
PLCG2 LCP2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11390650 20484116 10811803 12471105
PLCG1 LCP2 â—¼   ENZYMATIC_REACTION ✅ 51.0 1.0 ACSN 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483
CD28 LCP2 â—¼   ENZYMATIC_REACTION ✅ 23.0 1.0 ACSN 10086337 10209041 10567412 10811803 10982827 11447289 11777939 12175651 12640133 1313950 15197224 15567848 15574420 16582911 16887996 17496910 17673906 19449109 22437870 26552706 7523569 8551221 9359474
LAT LCP2 â—¼   ENZYMATIC_REACTION ✅ 51.0 1.0 ACSN 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483
CD247 LCP2 â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 10562324 10925299 11353765 11438547 11875494 12415267 12731048 12811837 15735648 16713974 17371980 20435894 20814939 21059766 23414611 23508573 23620508 23886063 24378531 7600293 8478617 8642247 9625766 9738502
LCP2 VAV1 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 12640133 19909365 20189481 21536650 22786724 23474202 23620508 24343663 24584089 9765283
FYN LCP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10648627 9047237
LCK LCP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 16354835 21725281 8702662 10648627 10556826
SYK LCP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 12817019 9047237 15388330 10660534 22534133 17353368 21725281 22786724 23901140 8892604 16189514 28736554 8702662 11046020 17148460 22267732
LCP2 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 23331499 12941616 9341187 23109003 21725281 15929943 11709089 16467851 11390650
CCL17 CCR4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 10498628 10488147 9169459 9430724 29637711 10699158 9169480 10540332 22633458
CCL5 CCR4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 8573157 12270118
SRC BMX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 27601470 17570479 16189514 10688651
ITK BMX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12573241
BTK BMX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12573241
TEC BMX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12573241
CXCL8 CXCR2 â—¼   PHYSICAL_INTERACTION 15.0 1.0 ACSN 15079071 17533374 17784835 17916596 18555777 18555778 18633355 18980965 21328342 21847358 23869868 24406209 25922287 26201938 27557510
CXCL8 CXCR2 â—¼   PROTEIN_INTERACTION 15.0 1.0 ACSN 15079071 17533374 17784835 17916596 18555777 18555778 18633355 18980965 21328342 21847358 23869868 24406209 25922287 26201938 27557510
CXCL6 CXCR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 8702798 9485196 16189514 9692902 22633458 12964882 10593335
CXCL3 CXCR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 8702798 10699158 16189514 22633458
CXCL8 CXCR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 70.0 1.0 Omnipath 7592830 8702798 22904195 9195914 10699158 7559482 12628493 23597562 10188995 15946947 8626516 8550564 9553055 1379593 8662882 19190236 8245475 9126332 10216072 1891716 9485196 8940121 15282370 9464567 11350788 11511101 9725262 10206993
PRKCA EZR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 14504278 15531580 10970850 11387207 21899702 15843435 9516463 15647376
SRC EZR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 16438931 22397367 14504278 25231728 21818323 24339867 15623525 18701134 22262457 24385580 18078820 28306714 15647376
GRK2 EZR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 52.0 1.0 Omnipath 17447891 25799996 14504278 15531580 24379416 25231728 31409639 11387207 15676024 14993232 21765462 21979959 25531779 19395553 10970850 10893267 15623525 21903131 19255442 15843435 16648854 33583073 34493594 19913059 18725408 26405038 16144865 21864676 16873375 15197272 24413175 18270268 25301939 11146558 21818323 31936668 17553936 30408026 25375189 20801872 26042733 33836044 27435765 19386264
AKT2 EZR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 14504278 15531580 10970850 11387207 15843435
SYK EZR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 28306714 12387735 16189514 23338238
CCL16 CCR5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22633458 11470772
CCL16 CCR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 11470772 22633458 10910894
CCL16 CCR8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22633458 10910894
SHC1 SYK â—¼   PHYSICAL_INTERACTION 71.0 1.0 ACSN 10022831 10086337 10358164 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11907067 11960372 12175651 12393695 12524384 12629515 12640133 13678960 14568985 15099563 15111329 15501236 15520864 15536084 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17101731 17496910 17673906 17883421 19414323 19449109 19909365 20150200015 21149606 21372296 21378271 21910624 22064427 22461508 23390297 23609447 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8189062 8226994 8551221 8837607 9000133 9157999 9295024 9314552 9396765 9570538 9632805 9753319 9763615
SHC1 SYK â—¼   SHARES_COMPLEX 71.0 1.0 ACSN 10022831 10086337 10358164 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11907067 11960372 12175651 12393695 12524384 12629515 12640133 13678960 14568985 15099563 15111329 15501236 15520864 15536084 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17101731 17496910 17673906 17883421 19414323 19449109 19909365 20150200015 21149606 21372296 21378271 21910624 22064427 22461508 23390297 23609447 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8189062 8226994 8551221 8837607 9000133 9157999 9295024 9314552 9396765 9570538 9632805 9753319 9763615
CD247 SHC1 â—¼   ENZYMATIC_REACTION ✅ 21.0 1.0 ACSN 10358164 10562324 11353765 11449354 12393695 12731048 15081523 15099567 18768831 20814939 21059766 2139103 23414611 24445665 7523143 8344348 8478617 8551221 9603467 9625766 9738502
LAT SHC1 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 10072481 10781611 10811803 11169415 12640133 14764585 16102570 16329184 19494291 19909365 23620508 25137453 7523143 7890616 8649391 8976179 9489702 9535722
SHC1 SYK â—¼   ENZYMATIC_REACTION ✅ 71.0 1.0 ACSN 10022831 10086337 10358164 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11907067 11960372 12175651 12393695 12524384 12629515 12640133 13678960 14568985 15099563 15111329 15501236 15520864 15536084 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17101731 17496910 17673906 17883421 19414323 19449109 19909365 20150200015 21149606 21372296 21378271 21910624 22064427 22461508 23390297 23609447 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8189062 8226994 8551221 8837607 9000133 9157999 9295024 9314552 9396765 9570538 9632805 9753319 9763615
SHC1 CXCL8 â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11283723 11447289 11449354 11777939 12175651 12393695 12640133 15520864 15567848 15574420 16076871 16582911 16887996 17496910 17673906 19223473 19449109 26552706 8551221
SHC1 PLCG1 â—¼   ENZYMATIC_REACTION ✅ 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
SHC1 FYN â—¼   DOWN_REGULATES ✅ - 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
SYK SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 45.0 1.0 Omnipath 19901323 9388490 9096689 16497976 15592455 9121430 10891441 17389395 11687594 10482988 20068231 10592173 9685404 9927207 15688026 7896829 9199344 9710204 17016520 11075717
PRKCA SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 12052829 19651622 18669648 17924679
LCK SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 74.0 1.0 Omnipath 19901323 20230923 16497976 9121430 15592455 9446569 17389395 18578522 10921922 10482988 10764799 18452278 20068231 18669648 12522270 9685404 10896916 9927207 12237775 8702728 8610109 19651622 9741627 9710204 19664994 17016520 10816433 11075717
FYN SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 96.0 1.0 Omnipath 19901323 20230923 16497976 9121430 15592455 16713569 9446569 17389395 23331499 18578522 10921922 10482988 10764799 18452278 20068231 10592173 18669648 12522270 9685404 10896916 7516469 9927207 12237775 8702728 8610109 19651622 9741627 9710204 19664994 17016520 10816433 11075717
TGFB1 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 12767520 22710166 19010789 16474430 19920116 22943793 17934056 20519943 12809600 21900405 11133108 14557817 15548370 17673906
MET SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 9083103 11687594 9660480 14990987 24728074 8084588 8939605 8947042 7731718 11884620 15688026 14685170
SRC SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 55.0 1.0 Omnipath 19901323 9388490 8939605 9096689 10971656 16497976 15592455 9121430 10891441 17389395 11687594 10329689 10482988 20068231 17570479 16189514 9685404 23109003 7516469 9927207 18840094 15688026 15212693 1409579 14963047 9710204 26551075 17016520 11075717
CSK SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 12767520 12048194 18829532 9819392 19380743 10037694 17673906
SHC1 DOK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11071635
SHC1 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 9544989 8631299 8621483 8950973 10891441 10783152 9278309 17673906 9344843 8294403 8021500 10025673 7520523 12955078 12577067 9199344 19531499 7760801 10570290 19380743 8235613 10675333 8114695
SHC1 GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 11707404 14982882 24728074 10871282 10194437 9804835 12808090
CD3G SYK â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 8226994 18818202 8862523 8340414 7522622 7530449 9314552
CD247 SYK â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 8226994 18818202 8862523 8340414 7522622 7530449 9314552
SYK SOS1 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 12456653 9341187 9705962 19372136 11071869 11449366 11909947 9697839 21822214
CD247 SYK â—¼   ENZYMATIC_REACTION ✅ 21.0 1.0 ACSN 10358164 10562324 11353765 11449354 12393695 12731048 15081523 15099567 18768831 20814939 21059766 2139103 23414611 24445665 7523143 8344348 8478617 8551221 9603467 9625766 9738502
SYK FYN â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 10358164 11907067 12524384 14568985 15536084 17101731 19909365 20150200015 21149606 21378271 21910624 23609447 8189062 8226994 9000133 9295024 9314552 9396765 9632805 9763615
SYK LAT â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10358164 10426994 11907067 12524384 12731048 15536084 16713974 19909365 20814939 21149606 21378271 21910624 23609447 8189062 8226994 9000133 9314552 9396765 9632805
VAV1 SYK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 8900182 7518558 23331499 12573241 8629002 23180781 11331248 11262396 10592173 16189514 10092764 8630736 8986718 29145629 9151714 16546099 8809042 24243840
FYN SYK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 7797565 7513017 17570479 10477689 9535867 16713569
SRC SYK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 7513017 17353363 17570479 16189514 9389695 23100514
SYK FGR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11672534 15536084
SYK LAT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 24782869 11368773 10811803 18068154 16938345 16189514 9891970
SYK VAV2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15345594 11262396 10592173 10749872
SYK PRKCA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 9531509 20068231 12881490 17192257 15583006
SYK PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 54.0 1.0 Omnipath 17081983 19690332 8627166 16497976 15592455 16126727 17389395 19534553 1689310 20068231 10592173 16153436 16038803 1708307 7682059 15144186 9697839 7831290 7744830 12601080 8885868 8657103 17016520
SYK PLCG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12771181 19783684 12470302 16449524 14656219 10469124 10933389
SYK LCK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 25.0 1.0 Omnipath 8798764 19664994 15536084 8621719 8798676 16497976 25990959 7518561 8845015 16189514 7539035 15659558
SYK BTK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 18083107 8629002 28368423 11598012 28359287 29455639 19369195 10051622 9012831 8630736 28088788 11226282
ITGB1 ITGA4 â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 12626562 19161977 19454690 19487819 22470492 9003039 9456329 9763606 9973479
ITGB1 ITGA4 â—¼   PROTEIN_INTERACTION 9.0 1.0 ACSN 12626562 19161977 19454690 19487819 22470492 9003039 9456329 9763606 9973479
ITGB1 FYN â—¼   ENZYMATIC_REACTION ✅ 14.0 1.0 ACSN 12731048 18037882 19161977 19454690 19487819 20644254 20814939 22067905 22470492 24202395 9003039 9456329 9763606 9973479
PRKCA ITGB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12138200 12435334 20926684 11700305 10592173
ADAM15 ITGB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10944520 9914169
ICOS CD40LG â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 10426994 11907067 15536084 16713974 20116985 21708958
CD40LG CD86 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11207245 11581322 11698286 11964292 14764699 15034038 15197224 17200410 17317815 17371980 17513775 23002440 23125331 7523569 8760829 9359474
CD40LG CD80 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11207245 11581322 11698286 11964292 14764699 15034038 15197224 17200410 17317815 17371980 17513775 23002440 23125331 7523569 8760829 9359474
CD40LG IL2 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 11581322 15034038 17200410 17371980 23125331 8760829
CD3D LCK â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
HLA-DRA LCK â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
LCK CD4 â—¼   PHYSICAL_INTERACTION 16.0 1.0 ACSN 10398592 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 3263576 8478617 8986721 9438848 9738502 9751747
LCK CD3G â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
LCK CD4 â—¼   PROTEIN_INTERACTION 16.0 1.0 ACSN 10398592 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 3263576 8478617 8986721 9438848 9738502 9751747
LCK CD247 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10652356 11062502 12731048 12740575 15536084 17544292 19290918 20814939 21127503 22513334 23620508 8478617 8986721 9438848 9738502 9751747
LCK FYN â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 9822663 15886116 10849438 12670394
LCK VAV1 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10398592 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 3263576 8478617 8986721 9438848 9738502 9751747
LCK ITK â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 3263576 8478617 8986721 9438848 9738502 9751747
CSK LCK â—¼   DOWN_REGULATES ✅ - 7.0 1.0 ACSN 10790433 11181701 12485116 15713798 19290918 8011291 8986721
CD4 LCK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 16888650 8104794 11854499 8246987 3262426 12601806 17653867 23109003 12007789 16189514 17005671 15489916 15047060
CD8A LCK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16818755 14500983 8814252
CSK LCK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 56.0 1.0 Omnipath 20346773 19901323 10692391 11489946 22566970 24463463 2141684 16497976 15592455 20813252 10799545 14967142 27547268 24764511 28522807 16537894 12485116 8193535 24227778 17897955 8183556 22426112 89123626 15489916 14610046 23109003 18691976 28448599 17947241 1639064 12414720 15144186 27460989 24816556 22507872 8631775 15743820 25979654 8945479 11181701 27045023 25595912 15259016
LCK ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 9500442 10571988 25386784 11145737 7539106 27748765
LCK ITK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 21747996 28516764 19132916 23109003 20305788 23982207 15771581 19690332 28644030 15144186 9312162 12842872 17192257 23946894
LCK CD247 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 9047237 19229850 23109003 16461343 1706070 1505025 16337488 17979845 8626561
LCK PLCG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 19901323 12181444 11606584 14656219 7682059 15144186 11507089 17570479 16497976 15184383
LCK LAT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16938345 12359715 12186560 27700984
LCK SIGLEC10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11733002
LCK CD3E â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12522270 2470098 15144186 11855827 15592455 16094384 15659558
LCK ADAM15 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11741929 16374509 16189514 25825872
LCK VAV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 20028078 24332539 898671 16285729 15708849 17050525 15699036 17570479 11005864 10669745 10636924
LCK PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11526404 15032589 14583609 23109003 8397196 10488096
LCK DOK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16537894 10799545 11841937 11489946
LCK VAV2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11516622 12400014 17570479 12454019
LCK CD28 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 7568038 22936936 27460989 16094384 10430626 8992971
CD2 LAT â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 10359122 15998796 16081768 19398758 19494291 26794910
CSK FYN â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 10790433 11181701 12485116 15713798 19290918 8011291 8986721
CSK FGR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 11489946 7515063 16537894 8612628 14967142
CSK HCK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11489946 16537894 10644735 11976726 14967142
CSK SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 55.0 1.0 Omnipath 11489946 23051580 20657842 20337577 7592628 23824743 21940449 26453921 22323292 14665621 17525734 14967142 3103926 23159740 16227616 1383688 12387813 20525307 10698938 7525268 19534553 16537894 26234813 10592173 12468645 7513429 24632723 7687537 21442427 22689825 25372749 11007774 9208935 18614016 28974561 21632985 19369195 17855352 7678701 23378895 9523754
CSK FYN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 1985196 8262983 11489946 16537894 9647655 25720756 18691976 10366594 19369195 1533589 1699196 7524477 16713569 15713745 14967142
CD4 CD247 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
HLA-DRA CD247 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
FYN CD247 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10591186 10648627 11062502 12218089 12731048 15536084 19290918 19909365 20814939 21378271 22683124 22863785 24440149 27192565 9738502
HCK CD247 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 12524384 21910624 24445665 8064233 8132624 8478617
CD4 CD247 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10398592 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 3263576 8478617 8986721 9438848 9738502 9751747
CD247 PLCG1 â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 10562324 10925299 11353765 11438547 11875494 12415267 12731048 12811837 15735648 16713974 17371980 20435894 20814939 21059766 23414611 23508573 23620508 23886063 24378531 7600293 8478617 8642247 9625766 9738502
CD247 VAV2 â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 10562324 10925299 11353765 11438547 11875494 12415267 12731048 12811837 15735648 16713974 17371980 20435894 20814939 21059766 23414611 23508573 23620508 23886063 24378531 7600293 8478617 8642247 9625766 9738502
CD247 IL2 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 10562324 11062502 11353765 11385609 12731048 15536084 20814939 21059766 23414611 8478617 9625766 9738502
CD247 LAT â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 10562324 10925299 11353765 11438547 11875494 12415267 12731048 12811837 15735648 16713974 17371980 20435894 20814939 21059766 23414611 23508573 23620508 23886063 24378531 7600293 8478617 8642247 9625766 9738502
FYN CD247 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 8578591 12522270 7589084 9677202 9047237 15144186 1454062 1530920 15592455 16094384 9368621 16713569 96108162 15659558 8760790
BCL10 CARD11 â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 11280761 11356195 11460167 12356734 14660645 16809782 16818229 17052756 17301840 17363905 17462996 17948050 18264101 18264787 20685844 21133840 21199863 21232017 21873235 24560716 24699077 24958845
BCL10 CARD11 â—¼   SHARES_COMPLEX 22.0 1.0 ACSN 11280761 11356195 11460167 12356734 14660645 16809782 16818229 17052756 17301840 17363905 17462996 17948050 18264101 18264787 20685844 21133840 21199863 21232017 21873235 24560716 24699077 24958845
PRKCB CARD11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16356855
PLCG1 LAT â—¼   PHYSICAL_INTERACTION 51.0 1.0 ACSN 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483
PLCG1 LAT â—¼   SHARES_COMPLEX 51.0 1.0 ACSN 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483
PLCG1 LAT â—¼   ENZYMATIC_REACTION ✅ 51.0 1.0 ACSN 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483
ITK LAT â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 11406363 12186560 15661896 25137453
VAV1 LAT â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10077632 10646608 10679059 10714681 10849438 10898494 11080163 11526404 11698448 11754814 11994416 12094222 12165654 12186560 12616499 12626562 12740575 12885870 12917349 14764585 15169881 16887996 19909365 20189481 22513334 22786724 22952938 25355530 25539813 26552706 8189062 8226994 9438848
LAT PLCG2 â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10072481 10086337 10567412 10781611 10811803 10982827 11169415 11447289 11777939 12175651 12640133 14764585 15567848 15574420 16102570 16329184 16582911 16887996 17496910 17673906 19449109 19494291 19909365 23620508 25137453 26552706 7523143 7890616 8551221 8649391 8976179 9489702 9535722
ITK LAT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11368773 9489702 10506192 12186560
CD8A LAT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10562325
LAT PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 27221712 11368773 9489702 12941616 15286727 10811803 23109003 24642916 16938345 11709089 16713569 15219999 16467851 9729044
LAT PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11368773 9489702 19132916 23109003 14696041
LAT VAV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11368773 23109003 16713569 12186560
VAV1 PLCG1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11007481 8986718 10395673 9099726
PLCG1 SRC â—¼   PHYSICAL_INTERACTION 36.0 1.0 ACSN 10072481 10781611 10811803 10925299 11169415 11476890 11532940 11994416 12040186 1281218 12845332 14585353 14764585 15214048 16488589 16919435 1712101 17397400 17496910 17517963 19568798 19909365 23523669 24584707 2536067 25456276 25572304 25960930 26552706 27216177 7682895 7890616 8226994 8649391 9535722 9846483
PLCG1 SRC â—¼   SHARES_COMPLEX 36.0 1.0 ACSN 10072481 10781611 10811803 10925299 11169415 11476890 11532940 11994416 12040186 1281218 12845332 14585353 14764585 15214048 16488589 16919435 1712101 17397400 17496910 17517963 19568798 19909365 23523669 24584707 2536067 25456276 25572304 25960930 26552706 27216177 7682895 7890616 8226994 8649391 9535722 9846483
VAV1 PLCG1 â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10077632 10646608 10679059 10714681 10849438 10898494 11080163 11526404 11698448 11754814 11994416 12094222 12165654 12186560 12616499 12626562 12740575 12885870 12917349 14764585 15169881 16887996 19909365 20189481 22513334 22786724 22952938 25355530 25539813 26552706 8189062 8226994 9438848
ITK PLCG1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 11406363 12186560 15661896 25137453
PRKCA PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 2820980 8885868 10592173 1370476
SRC PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 43.0 1.0 Omnipath 8388373 16497976 16126727 16713569 17389395 1689310 20068231 17570479 16153436 16038803 1708307 7682059 7510703 18594017 12601080 8885868 8657103 17016520
BTK PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9550384 15010370 15184383
FYN PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8395016 10586033 7682059 16713569
HCK PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 17081983 16497976 15592455 16126727 17389395 1689310 20068231 16153436 16038803 10586033 1708307 7682059 15144186 12601080 18707149 8885868 8657103 17016520
GAB1 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 8596638 23331499 11507676 24728074 10871282
ITK PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 44.0 1.0 Omnipath 24412752 15975899 22847294 20237289 15623534 19690332 12163161 23933134 30131370 15184383 16126727 12730118 31196981 17389395 23331499 19534553 20519342 16081816 15215251 17372230 17420479 27221712 17148460 21760611 12952950 25916191 19427038 27941787 10586033 34429382 23109003 11564877 12029091 12941616 19412549 14568990 28644030 11709089 8657103 15951569 22649724
VAV1 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 67.0 1.0 Omnipath 11340169 10849438 22952938 9099726 12626562 12917349 12165654 16713569 25539813 8673706 19909365 7518558 10077632 11278486 26552706 10395673 12885870 12573241 8629002 11526404 10898494 25355530 17050525 10592173 11698448 10646608 11094073 11994416 20189481 12670394 9550384 12616499 22513334 10679059 23109003 9891995 11007481 12740575 17540168 11804587 8630736 17054426 11754814 8986718 9438848 11080163 29145629 12941616 10714681 14764585 15169881 26192618 22786724 8226994 15010370 12094222 8189062 16887996 11709089 16467851 24243840 12186560
FGFR1 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 17081983 20932831 1656221 16126727 15592455 9660748 19665973 7991458 1689310 8321198 8050374 16153436 17496910 25241761 16038803 10459043 23063561 1708307 7682059 15144186 12601080 9052794 8885868 8657103 15212693
PLCG1 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 15953601 12084069 7629168 9020117 16713569 10913276 17474147 10940929
PIK3CD VAV1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 7691807 7687539 7687428 15187135 10706702 7528218
GRAP2 VAV1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11007481 8986718 10395673 9099726
VAV1 SOS1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11007481 8986718 10395673 9099726
VAV1 PLCG2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11007481 8986718 10395673 9099726
FYN VAV1 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10591186 10648627 12218089 12731048 15699036 19290918 19909365 20814939 21378271 22683124 22863785 24440149 27192565 9738502 9822663
SRC VAV1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17686471 8986718 11007481 10395673 9099726
CD4 VAV1 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10398592 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 3263576 8478617 8986721 9438848 9738502 9751747
CD28 VAV1 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 10426994 11907067 1313950 15197224 15536084 16713974 22437870 7523569 9359474
VAV1 CDC42 â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10077632 10646608 10679059 10714681 10849438 10898494 11080163 11526404 11698448 11754814 11994416 12094222 12165654 12186560 12616499 12626562 12740575 12885870 12917349 14764585 15169881 16887996 19909365 20189481 22513334 22786724 22952938 25355530 25539813 26552706 8189062 8226994 9438848
VAV1 PLCG2 â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10077632 10646608 10679059 10714681 10849438 10898494 11080163 11526404 11698448 11754814 11994416 12094222 12165654 12186560 12616499 12626562 12740575 12885870 12917349 14764585 15169881 16887996 19909365 20189481 22513334 22786724 22952938 25355530 25539813 26552706 8189062 8226994 9438848
FYN VAV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 11262396 15699036 11005864 9438848 16713569 15933714 9822663
TEC VAV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 7651724
VAV1 CDC42 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 10849438 22952938 9695188 12626562 12917349 12165654 25539813 19909365 14757747 18511940 10077632 26552706 12885870 11526404 10898494 25355530 11698448 16189514 10646608 11994416 20189481 22513334 12616499 10679059 23109003 12740575 11754814 9438848 11080163 10714681 14764585 15169881 26192618 22786724 8226994 12094222 8189062 11287617 16887996 12186560
VAV1 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 8554611 16713569 8289830
PIK3CD FYN â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9590251 7537740 8995358 9259313
ITGA4 FYN â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 12626562 19161977 19454690 19487819 22470492 9003039 9456329 9763606 9973479
FYN CD28 â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 10591186 10648627 12218089 12731048 19290918 19909365 20814939 21378271 22683124 22863785 24440149 27192565 9738502
FYN CD80 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 9822663 15886116 10849438 12670394
FYN CD86 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 9822663 15886116 10849438 12670394
FYN IFNG â—¼   DOWN_REGULATES ✅ - 17.0 1.0 ACSN 10591186 10648627 12218089 12731048 16286920 19290918 19909365 20814939 20819927 21378271 22437870 22683124 22863785 24440149 27192565 28900677 9738502
FYN WAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 18083107 25709608 7565724 8805332 10224664 18088087 19690332 12431372 12235133 16713569 15592455 10532312 14707117
FYN PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 7515100 1334406 16713569 1652056
FYN SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17474147 16713569 9856337
FYN PLCG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 19901323 8395016 12181444 11606584 14656219 7682059 15144186 11507089 16497976 16713569
FYN DOK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11489946 16537894 11841937 11825908 15345598
FYN CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 20026641 22264731 24511551 25241761 22340496 12640114 25803041 26509276
FYN BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 17129785 9188452 9020138 10739664 31413325 16713569 11181827 9360983 17474147
IL4 IFNG â—¼   DOWN_REGULATES ✅ - 17.0 1.0 ACSN 10485906 10820262 11160275 11371360 11870632 12401408 12433365 12496409 12818165 18250477 1825141 20184663 20856220 21097505 23124025 2965306 9834059
SOCS1 IFNG â—¼   DOWN_REGULATES ✅ - 6.0 1.0 ACSN 10485906 12193701 12223527 12811837 21469115 23124025
FOS IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19285436 16713974 7759501 8756632 12842891 12432566
CCL5 CCR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 10734056 7622448 8642344 22633458 10733106 10699158 9289016
CCL5 CCR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 10734056 7622448 14637022 22633458 9115216 9624164 10699158 11116158 12270118 7545673 9289016 9336350 10910894 8530354
CCL5 CCR5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 60.0 1.0 Omnipath 16298345 10488147 28381538 10699158 22633458 9289016 12213786 8663314 11449371 10318947 12964882 25923671 9207005 23480650 11116158 10477718 14637022 9334377 9790730
CYBA CYBB â—¼   PHYSICAL_INTERACTION 25.0 1.0 ACSN 10679059 10714681 11062502 11146654 11385609 11747822 11907067 12626562 12740575 14697347 15169870 15184873 15536084 15927447 17517963 18423981 18809714 19372727 19380816 19732719 21178402 21383238 22157818 22827577 27331412
CYBA CYBB â—¼   SHARES_COMPLEX 25.0 1.0 ACSN 10679059 10714681 11062502 11146654 11385609 11747822 11907067 12626562 12740575 14697347 15169870 15184873 15536084 15927447 17517963 18423981 18809714 19372727 19380816 19732719 21178402 21383238 22157818 22827577 27331412
CCL26 CCR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 16102831 10488147 15207250 10699158 16339911 22633458
CCL26 CCR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22633458 15039444
CCL26 CCR5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22633458 29637711 15039444
CCL26 CX3CR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22633458 20974991 29637711
FOS TGFB1 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 15067049 15749884 16243976 16327802 16393692 16394015 16413922 16713974 17404308 17485448 19667062 20547845 21372296 21385848 22634314 23390297 23430059 9064320
TGFB1 SRC â—¼   ENZYMATIC_REACTION ✅ 56.0 1.0 ACSN 10671552 11133108 11348595 11476890 11955436 11967263 12051714 12426320 14557817 15001769 15279786 15548370 16039586 16099633 16371504 16474430 16919435 17143292 17303408 17496910 17517963 17660363 17928543 17934056 17936032 18037882 18590585 19010789 19029934 19109155 19171760 19619488 19734908 19920116 20519943 20644162 20705860 21278795 21666923 21900405 22007144 22174153 22203675 22370635 22674073 22703233 23343194 24023259 25572304 25730849 26552706 27216177 7542250 7575488 7594497 8666229
PIK3R2 HRAS â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
HRAS PRKCZ â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 10228164 15314172 11689445 28539435 11726503 19879889 8635462
HRAS PIK3CB â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
VAV2 HRAS â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 10934226 11080163 11262396 12094222 14623913 15365099 15886116 16713974 9822605
HRAS FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
HRAS SOS1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
SOS1 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 12628188 10208427 16713569 10913276 23331499 18454158 15507210 10592173 17673906 17496910 26721396 20133692 19141281 23132018 11560935 9447984 9690470 17084389
SRC HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12695509 9626657 9020108 25157176 33413561
HRAS PIK3CD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9069260 9113989 9235916 21779497 11739523 10545207
HRAS PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9069260 9727023 17145710 10922060 11136978 21779497
HRAS PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 9069260 9113989 8052307 24412244 17540175 9931431 11313862 14724584 10592173 9150145 8665852 10783161
HRAS BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 17145710 7706312 14970219 18567582 12932319 8073291 1386920 23331499 8601312 9154803 18988627 8668348 21779497 19541618 19933846 17563371 18098337 16803888 26165597 24441586 16135787 12917261 15710605 10545207
HRAS AFDN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17145710 10334923 10922060 8557659 10545207
SRC ARHGAP35 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 11476890 12094222 16919435 17496910 17517963 25572304 26552706 27216177
SRC ARHGAP35 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 19901323 21937717 18541700 20068231 9819392 10592173 11309200 16497976 15592455 17570479 16513268 7542246 30664792 17016520 32540970
SRC BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 62.0 1.0 Omnipath 19901323 24962474 11514617 8670206 15316024 20927395 8070403 17389395 12480533 22710723 30422386 25976166 17570479 21963850 12972425 20103658 17129785 10487518 15817476 21301050 10739664 17038317 21765460 17016520 12397603 15212693 15020686 10542110 23457577 10085298 12615911 15272013 21034468 11604500
HCK BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9020138
FGFR1 BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11019781 12601080
FOS CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 11973337 18317936 12218154 22095787 12748173 10969814 15005855 17586662 16818736 24048734 14686613 16846747 15057743 15615716 8999951 25567680 19173296
ESR1 CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 15208657 16029657 19440537 14991571 18669446 17932106
CD80 CD86 â—¼   PHYSICAL_INTERACTION 25.0 1.0 ACSN 10477595 11207245 11964292 12810107 14764699 15034038 15197224 17513775 17629517 18585785 20231889 20805416 21220452 22076556 22437870 23390297 24218453 25215878 25384214 25582338 26405600 7512027 7523569 8920882 9359474
CD80 CD86 â—¼   PROTEIN_INTERACTION 25.0 1.0 ACSN 10477595 11207245 11964292 12810107 14764699 15034038 15197224 17513775 17629517 18585785 20231889 20805416 21220452 22076556 22437870 23390297 24218453 25215878 25384214 25582338 26405600 7512027 7523569 8920882 9359474
CD80 CD28 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11964292 12810107 14764699 15197224 17513775 17629517 18585785 20231889 22437870 23390297 25215878 25582338 26405600 7512027 7523569 9359474
CD80 CD28 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 21530327 7964482 22437870 2164219 1847722 23954143 15610849 7545666 21982860 21487479
CD28 IL2 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 10426994 11907067 1313950 15197224 15536084 16713974 22437870 7523569 9359474
FOS IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 20557936 8893011 11260070 11685114 8397339 1737937 9605137 9590239 11262396 7989759 1916630 8473495 10601992 8114694 22474330 18725523 9233628 11385624 2518655 15170389 8468462 7565732 12432566 8660843 7739550 1305903 20680391 19181930
IL4 SOCS1 â—¼   ENZYMATIC_REACTION ✅ 17.0 1.0 ACSN 10485906 10820262 11160275 11371360 11870632 12401408 12433365 12496409 12818165 18250477 1825141 20184663 20856220 21097505 23124025 2965306 9834059
CXCL10 CCR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 11110785 22633458
FOS CSF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9190901 1900839 8135780 11509589 9028942 12432566 7579683 8631792 9862439
CD86 CD28 â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10477595 11207245 11964292 14764699 15034038 15197224 17513775 20231889 20805416 21220452 22076556 22437870 23390297 24218453 25215878 25384214 7523569 8920882 9359474
CD86 CD28 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 21530327 22437870 18205792 23954143 11021528 21931534 21487479 7513726
SRC PIK3CA â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 12682286 15314172 20861220 18657504 11689445 12431978 25587652 11044445 22266855 11029403 11029009
SRC CDC42 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 11476890 12094222 16919435 17496910 17517963 25572304 26552706 27216177
SRC VAV2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17686471 8986718 11007481 10395673 9099726
PRKCB SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 17496910 11940581 21386996 11447289 19615955 16488589 6321473 8321321 12845332 11313945 12040186 19568798 15567848 14585353
ACTN1 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17145710 16291744
PRKCA SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 17496910 11940581 21386996 10527887 2996780 11447289 19615955 16488589 6321473 8321321 12845332 11313945 2136766 17570479 12040186 19568798 15567848 14585353
PRKCE SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 17496910 11940581 21386996 11447289 19615955 11834516 16488589 6321473 8321321 12845332 11313945 12040186 19568798 15567848 14585353
PRKCZ SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 17496910 11940581 21386996 10527887 11447289 19615955 16488589 6321473 8321321 12845332 11313945 16189514 12040186 19568798 15567848 14585353
GNAI1 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23109003 11007482 10753828 9722546
SRC CDC42 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 14506284 26816343 9626657
SRC PLCG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 30819914 12181444 11606584 14656219 7682059 15144186 11507089
SRC PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12750372 10592173 17275257 10830300
SRC ARRB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 17456469 17456551 16432186
SRC PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21780115 15032589 11526404 23109003 22880054 10488096
SRC SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17474147 9856337
SRC CDH5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 36.0 1.0 Omnipath 28712573 24525631 26504080 24590762 25675998 25447529 24358106 27381080 20708398 33836597 26905827 24136461 19644057 21123455 24446483 22648953 22897853 24583284 29326721 16909109 33604918 21037229 25924235 28057793 28119542 16027153 26598555 33712448
SRC GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 26706435 15574420 19881549 12941962 21442024 12808090
SRC HSP90AB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17855507
SRC VAV2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 1531699 23118862 23457577 17570479 1311423
SRC MET â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 24728074 24034250 9837958 17570479
SRC HNF4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16713569 22308320
SRC GRK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12624098 16725308 11278940 11566877 16189514
SRC CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 46.0 1.0 Omnipath 22605996 16492141 27177845 23824743 25423132 25850673 24816560 27203386 11836526 22515442 26918136 10593980 15782139 9592087 22056988 12571228 17087658 20840866 23640056 21195420 25164010 26453937 9278444 16831887 23476652 12123611 11279024 14517306 21903109 22200182 20026641 22264731 25041845 12408824 22247700
SRC ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 15784253 25364741 17400812 16957778 17627277 15140878 11032808 23065768 12736255 7539106 17921256 27472465 14963108 24487689 25275301 12630920 22865929 14766010 30148069 11013076 15020686 9500442 17284441
SRC KHDRBS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 9038356 10467411 8766817 22745667 7537265 7516469 11960376 10635328 1374686 18606683 16169070 16713569 1545818 15190072
SRC AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 11445557 25241761 23242524 18283331 12600984
SRC BTK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 19109164 23170196 8629002 29455639 10051622 8630736 26165234 9052864
VAV2 CDC42 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 10934226 11080163 11262396 12094222 14623913 15365099 15886116 9822605
CDC42 WAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 55.0 1.0 Omnipath 10360579 10559936 10940259 8643625 9422512 9742969 25502805 10684602 15075243 10511705 15020669 12235133 12769846 8625410 11340065 15361624 16189514 15003621 16293614 20936779 22252508 10934474 11413130 15713627 10747096 11950587 27871158 10724160 10360578 10713100 10467124 10068673 9660763 25758716 11248548 10802735 31515488 18719708 10613909 10461188
CDC42 PRKCZ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23109003 17353362 10733591 10873802
ITK CD28 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 19901323 10586033 22936936 8946678 15144186 15592455 16094384 8992971
CD28 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23109003 17722974 22315502 8146197 16107703 7509360 8080844 15790353
CD4 CD3D â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
CD4 HLA-DRA â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
CD4 CD3G â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
CD4 CD3E â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
CD4 ITK â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10398592 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 3263576 8478617 8986721 9438848 9738502 9751747
CD4 CCR5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17145710 10816381 29637711
ITK BTK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 12445832 12573241 8629002 8630736 16497976 11598012
ITK TEC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12573241
ITK SIGLEC10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11733002 12163025
TEC BTK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 12445832 12573241 8629002 8630736 16497976 11598012
TEC PLCG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15184383
TEC DOK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11071635 9651683 9020138 11825908 10823839
GRK6 CXCR4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 30936203 25355818 20048153 24309376 19116316 28328745 24489825
CXCR4 GNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520 10506573
FGFR1 PIK3CA â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 17505008 18757403 21666749 11689702 21711248 11739186 21160078 14534538 15448205
FGFR1 SOS1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11353842 8780727 11447289 7559490 9182757
MBD2 FGFR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 22152480 22371483 20650264 20644511 23970103 20714105 25254151 20851996 23711388
PRKCE FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 17496910 11940581 21386996 11447289 19615955 16488589 6321473 8321321 12845332 11313945 23564461 12040186 19568798 15567848 14585353
FGFR1 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17496910 15117958
FGFR1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17496910 25241761 22558232 11401320 12040186 19568798 14585353
ESR1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11029009 15569929 18450422 20664923 15496458
PRKCZ AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 11585925 15884057 14560023 16189514 11748077 18353613 11723139 10085094
PIK3CA AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 25793261 19117013 21041639 24950409 21816939
AKT1 BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 27.0 1.0 Omnipath 19651622 20058876 14688280 11510412 25241761 20230923 20068231 18452278 11410590 17570479 10869359 18669648
AKT1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 20858269 23331499 20028971 11882383 21303971 17680028 20214616 22094462 17287208 17374729 20398329 21506126 21402455 12040186 19623618 12063252 18218901
AKT1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 99.0 1.0 Omnipath 17428466 15207235 17145710 12052830 10729337 8250835 11756412 11923280 16914735 17623045 16697215 8524413 12054501 20398329 18372248 21506126 20028971 12040186 15808505 16543730 20138985 23331499 21303971 16009706 10385618 20214616 23180781 9373175 16039586 15829723 18988627 16282323 11577096 11035810 18669648 18216173 15169778 12851486 16123141 11882383 23109003 9065430 18691976 22094462 10949026 22710759 11715018 12459251 18636226 17192257 11254732 11278246 20858269 9812896 9582355 15023346 17680028 19369195 7945242 12900420 23552696 18387957 10722653 20832730 18570873 12147701 18505846 17052453 17693255 18218901
AKT1 AKT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11546794 14500673 12176337 11445557 9736715 12149249 11278835
AKT1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 18521086 26944939 11108261 17627277 20101208 17570479 15604293 23169992 26554417 16452229 15193262 7838153 12374744 11139588 26272591 11432835 20179234 11507039 9528769
AKT1 GSK3A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 110.0 1.0 Omnipath 15772344 19797085 23549785 20371716 11884598 25584893 11583116 11520785 14550568 19920184 15710331 21530327 9065430 16188907 24632852 12515807 11289110 24879152 20110348 12890758 15333638 14633703 11803463 16123357 8524413 21868755 12054501 23142783 25714023 16585200 15808505 22497526 16767165 19117997 14744935 19443725 21118801 18691976 18209096 11563975 17192257 11085518 19369195 19043530 11896604 10716737 19914182 19996208 21441927 32645325 15805282 21464307 34381779 16223362 12181443 15755769 11331582 11035810 21445305 27331409 16987514 11340086 15723049 22499768 18701488 11749387 20686112 11509608 19413330 20233866 15950778 20708687 14660586 17386267 11577096 15371448 11956225 12649200 16476742 11254732 21575859 14988390 11779850 19574224 20739666 17200115
ESR1 FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 8114761 9528985 18414489 10037443 21813366 11726205
PRKCZ MET â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 17496910 11940581 21386996 15075332 11447289 19615955 16488589 6321473 8321321 12845332 11313945 12040186 19568798 15567848 14585353
PRKCZ GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 18353303 14657655 11481324
PRKCA GRK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11042191 9013639
PRKCA GSK3A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 25.0 1.0 Omnipath 18691976 8524413 12054501 14556709 1324914 11749387 19413330 11884598 11035810
PRKCA ADCY2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 8383119 8900209 9366262 7938004 9268695
PRKCA MET â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 17496910 11940581 21386996 15075332 11447289 19615955 8294430 16488589 6321473 8321321 12845332 11313945 17570479 94124523 12040186 19568798 15567848 14585353
PRKCA F11R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 7646439 11027562
GNAI1 HCK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23109003 11007482 10753828 9722546
HCK ADAM15 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 11741929 16374509 16189514 25825872
HCK WAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 17145710 18083107 19901323 10068673 12769847 18088087 9742969 19690332 12029088 12235133 16497976 12769846 19234535 15592455 14707117
HCK PLCG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 19901323 12181444 11606584 14656219 7682059 15144186 11507089 16497976
HCK SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17145710 12029088 23397142 17141806
HCK PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17145710 21780115 11526404 15032589 23109003 12029088 22880054 10488096
ARRB2 GNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520
ARRB1 GNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520
CCR5 GNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520 15251452
GNAI1 ADCY5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 9748257 23109003 15539636 7935349 16460834 11376933
GNAI1 FGR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23109003 11007482 10753828 9722546
HLA-DRA CD3E â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
HLA-DRA CD3D â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
HLA-DRA CD3G â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
GSK3B PRKCE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20350291 34143863 18604201
PRKCE MET â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 11447289 8321321 11313945 94124523 12040186 7925482 6321473 15567848 19568798 14585353 17496910 21386996 8294430 11940581 15075332 19615955 12845332 15212693 16488589
GAB1 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11043767 8596638 11278704 10194437 10592173
PIK3R3 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 8596638 22402981 9415396 11733063 26496610 25814554
AKT2 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 17145710 21303971 11882383 17680028 9065430 20214616 22094462 23552696 12434148 20398329 21506126 26051358 16293724 20028971 12040186 9712142 18218901
GSK3B CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 183.0 1.0 Omnipath 22415718 11967263 27158593 29455668 19303846 19797085 8638126 19293931 23056571 22662165 25352148 16611981 27068260 28337019 10671551 21743491 20688898 16293724 23721711 23552738 18687691 28977889 19622173 12051714 25241761 27683053 28549350 22699938 19565571 23076981 21562161 19575820 20219694 20537194 10330181 21986938 29183346 27773936 11251183 19711366 21035499 19675674 7542250 23151663 24451375 14663202 23804296 8524413 25639486 23770025 18070361 26892600 30143633 9233789 19667122 27507058 19061640 19223551 29387014 23331499 16199882 11533658 18644116 24501426 24913829 11835406 17318191 26014148 25366337 28183999 22640743 26910375 12000790 12114015 18387957 19107203 9832503 16371461 29805709 27462866 20137080 27902311 12040186 19576224 25644994 12615961 19060929 25897075 12851486 15465828 17053159 18952601 10228155 15020233 17444818 20140245 26453498 17052453 16944320 24015932 23602568 24975844 24931005 28948000 20080742 23209942 30271168 28220106 16520547 28430641 11818547 25546293 27672271 11955436 11154277 26373837 16039586 23778311 28697793 20302655 25136145 26905812 22216350 8666229 12957350 23109003 10074433 28529629 20215423 21329734 11254732 9501208 27098453 27281614 30279527 19631635 25482131 18455992 24403311 11274345
GSK3B ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 10428798 10949034 17609434 15461668 9528769 12118371 15059947 16076840 17570479 7491495 12093745 8308015 15212693 15528270 7838153
AKT2 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 21303971 11882383 17680028 20214616 22094462 17287208 20398329 21506126 20028971 12040186 18218901
GSK3A CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 9601641 9482734 12051714 12000790 11818547 12114015
CDH5 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18287330 17057644 12413882 20123964 23243000 21255999
MET CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 17496910 25163657 24511551 22558232 11929826 16909210 24342833 12040186 26654598 19568798 14585353 23083465
PRKCB GSK3A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 18691976 8524413 12054501 19413330 11749387 11884598 11035810
AKT2 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 11139588 11432835 11507039 9528769 7838153
GRAP2 PLCG2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11390650 20484116 10811803 12471105
MET GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 10978177 17389395 19901323 10753869 15574420 15212693 10913131 10734310 11896055 20068231 10995442 9890893 16497976 14685170 17016520 18669648 11779868
PIK3R3 PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 8596638 22402981 11733063 25814554
FGR PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21780115 15032589 11526404 23109003 22880054 10488096
PLCG2 SOS1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11390650 20484116 10811803 12471105
CCL3L1 CCR5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 11170631 10364178 10477718 16298345 11734558 11449371 11700073 9790730 22633458 12964882
CCL14 CCR5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 16298345 20483925 22633458 11085751 12964882
ITGAL F11R â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 15681301 15528364 17525755 11812992
IBTK BTK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18596081 11577348
PRKCB BTK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 12679936 29455639 12417015 11598012
BTK PLCG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 49.0 1.0 Omnipath 19901323 19690332 15184383 16497976 33419778 34141433 15509800 30344948 12235209 14656219 17290227 12780340 12181444 11606584 21074890 7682059 11507089 15144186 22409342 29455639 17239630 10498607
PRKCB MET â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 17496910 11940581 21386996 11447289 19615955 16488589 6321473 8321321 12845332 11313945 12040186 19568798 15567848 14585353
PRKCB IBTK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 21482705
CCL15 CCR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10699158 9346309
CCL23 CCR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 9886417 9558365 12381680 10699158 10660125 22633458
CCL3L1 CCR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 11170631 11449371 12381680 9115216 9624164 7545673 10202040 10660125 22633458 8530354
CCL14 CCR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 9687537 9548457 15905581 12381680 20483925 9346309 9405404 24218476 22633458 11085751
CCL28 CCR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 10975800 22633458 12964882
CCL3L1 CCR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11449371 7594543 22633458
CCL15 CCR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10699158 9346309
CCL14 CCR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9548457 9346309 11085751
CCL18 CCR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 10640766 29637711 23999500 24218476 22633458 23951310
CCL27 CCR10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 10781587 11821900 12718728 10725697 22633458
CCL28 CCR10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 10975800 10781587 22633458
CCL25 CCR10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10706668
CX3CL1 CX3CR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 9390561 10488147 14607932 10699158 28389721 11432858 16189514 22633458 9931005
CCL17 CCR8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12832759 10699158 9521068 10910894
CCL25 CCR9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 10498628 10699158 11159507 22633458 10229797
CCL18 CCR8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 24218476 23999500