Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
TRAV19 TRBC1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAV19 TRBV7-9 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAV19 CSK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15489916 15489910
TRAV19 PRKCQ â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 16978534 12473184
TRAV19 CD247 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAV19 CD3E â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAV19 CD4 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAV19 TRBV12-3 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAV19 LCK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAV19 CD3D â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAV19 TRAV8-4 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAV19 TRAC â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAV19 CD3G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAV19 TRAV29DV5 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD4 TRBV12-3 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRBV12-3 CD3D â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRBV12-3 TRBC1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRBV12-3 CSK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15489916 15489910
TRBV12-3 TRAC â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRBV12-3 TRAV29DV5 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRBV12-3 TRBV7-9 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRBV12-3 LCK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRBV12-3 CD3E â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRBV12-3 TRAV8-4 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRBV12-3 CD247 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRBV12-3 CD3G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRBV12-3 PRKCQ â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 16978534 12473184
TRAV8-4 TRAV29DV5 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAV8-4 TRBV7-9 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAV8-4 CSK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15489916 15489910
TRAV8-4 TRAC â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAV8-4 CD247 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD4 TRAV8-4 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAV8-4 PRKCQ â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 16978534 12473184
TRAV8-4 LCK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAV8-4 CD3E â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAV8-4 CD3G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAV8-4 TRBC1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAV8-4 CD3D â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAC TRBV7-9 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD4 TRBV7-9 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD3D TRBV7-9 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRBC1 TRBV7-9 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRBV7-9 PRKCQ â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 16978534 12473184
TRBV7-9 CD247 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRBV7-9 TRAV29DV5 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRBV7-9 CSK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15489916 15489910
TRBV7-9 LCK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRBV7-9 CD3G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRBV7-9 CD3E â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
PTPN6 CSK â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18173375 18759926
CD247 CSK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15489916 15489910
CD3E CSK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15489916 15489910
TRAV29DV5 CSK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15489916 15489910
CD3G CSK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15489916 15489910
TRBC1 CSK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15489916 15489910
LCK CSK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15489916 15489910
CD3D CSK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15489916 15489910
TRAC CSK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15489916 15489910
CD4 CSK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15489916 15489910
CSK PTPRC â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 6672875 7507203
PIK3R1 B2M â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15536084 11907067
HLA-C B2M â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5211709 10429675
TRAC TRBC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5215899 12429093
CD4 TRAC â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAC TRBC1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAC TRAV29DV5 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAC PRKCQ â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 16978534 12473184
TRAC CD3G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAC LCK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAC CD3E â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAC CD247 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAC CD3D â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAV29DV5 LCK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAV29DV5 CD247 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAV29DV5 CD3E â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD3D TRAV29DV5 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAV29DV5 CD3G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRBC1 TRAV29DV5 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRAV29DV5 PRKCQ â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 16978534 12473184
CD4 TRAV29DV5 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD4 TRBC1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRBC1 CD3D â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRBC1 PRKCQ â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 16978534 12473184
TRBC1 LCK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRBC1 CD3E â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRBC1 CD3G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TRBC1 CD247 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
JUN BATF3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12087103
BATF3 IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12087103 10878360
CD8A CALR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29997244 20178071
CALR HLA-A â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
CD2 LCK â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 6548030 9677430
CD2 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8557753
SHC1 CD247 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7544002 6730386
VAV1 CD247 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8986718 16546099
CD247 CD3G â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
CD3G CD247 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD3E CD247 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD3D CD247 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD247 PRKCQ â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 16978534 12473184
PTPRC CD247 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 7526385
LCK CD28 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8946678 9973466
CD4 CD3D â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD3D CD3G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD3D LCK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD3D PRKCQ â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 16978534 12473184
CD3D CD3E â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
ETS1 CD3D â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12324448
CD3E SHC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6731413 11855827
LCK CD3E â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD4 CD3E â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD3E CD3G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD3E PRKCQ â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 16978534 12473184
CD3G VAV1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8986718 16546099
CD4 CD3G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
LCK CD3G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD3G PRKCQ â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 16978534 12473184
CD4 LCK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
DNMT1 CD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18586981 20223637
RUNX3 CD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17641686
RUNX1 CD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17641686
TP53 CD59 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11812190 12553064
PIK3R1 CD80 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12670391 8621607
LCK CD80 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8946678 9973466
LCK CD86 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8946678 9973466
PIK3R1 CD86 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12670391 8621607
RUNX3 CD8A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23018457 14500656
PATZ1 CD8A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16491076 20383150
ETS1 CD8A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8413295
EOMES CD8A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17566017 20060330
TBX21 CD8A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20060330 25148025
HLA-B CD8A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9331948 10809759
HLA-C CD8A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12899833 10809759
JUN CREM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21757709
RELA DNMT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23457487 24025864
DNMT1 PTPN6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15870198 24058781
TP53 DNMT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18431400
RUNX3 EOMES â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20399120 19139168
TP53 EOMES â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15843459
ETS1 LCK â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7970721
ETS1 IL2RB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8413220
MAF ETS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9566892
RELA GATA3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20660789
RUNX1 GATA3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16995417 12835475
NOTCH1 GATA3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15356142 17658279
RBPJ GATA3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15356142 17658279
GATA3 ZBTB7B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19729201 18776904
MYB GATA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17641686
RUNX1 GFI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20516218 24014243
LNX1 GRAP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
LNX2 GRAP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
ZBTB7B GRAP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
GRAP2 LNX2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
GRAP2 LNX1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
GRAP2 LCP2 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
TP53 HLA-A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15501971 12857899
HLA-E PIK3R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15536084 11907067
TP53 HLA-E â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1400626 1652755
JUN HRK â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19304750 17428807
TCF3 ID2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19321746 0900912106
TP53 ID2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16557594
IL2RB IL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15178252 16477002
MYB IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1349016 11486019
IL2RA IL2RB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15178252 16477002
IL2RA IL2RG â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15178252 16477002
JUN IL2RA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14660657 7889400
RUNX1 IL2RB â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 15084276 18003603
IL2RG STAT5A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8709637 7489741
IL2RG SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16189514 8643566
IL2RG PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10421845
IL2RG STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16189514 11418623
TP53 JUN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11350971 10984493
RELA JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17310108 10646503
LAT SHC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10811803 8663278
PIK3R1 LCK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5220762 8246987
MYB LCK â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7970721
LCK PTPN6 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 8114715 7028063
LCK PTPRC â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 6672875 7507203
SHC1 LCP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6548125 9716598
LNX1 SRSF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
VAV1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16713569 11331248
PIK3R1 VAV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16713569 11331248
STAT4 PRF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12372421
PTPN6 STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12220225
PTPN6 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8541543
RELA TBX21 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17407192
LCK CD3E â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 11855827 14523017
CD28 GRAP2 â—¼   PHYSICAL_INTERACTION 817.0 0.81 STRING 36370105
HLAG 1B07 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
LNX1 LNX2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22889411 11922143
SHC1 PIK3R1 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 16219545 5217992
SHC1 SHC2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
CSK JUN â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 19818398 16740711
B2MG CD8A â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 12853576 11914379
DNMT1 RUNX1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 15735013 28533407
TBX21 GATA3 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 17075044
SHC1 IL2RG â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 16189514 8643566
LCP2 SHC1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 9716598 16189514
CD247 CD3D â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CD3D CD3G â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
LCK PTPN6 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
CSK LCK â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 15144186 12485116 31980649
BATF3 JUN â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
ETS1 RUNX1 â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
CD8A LCK â—¼   PHYSICAL_INTERACTION 848.0 0.84 STRING 36370105
CD8A 1B07 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 10809759 9331948
CD8A 1C01 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 10809759 12899833
CD86 CD28 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 7513726 21931534 11021528 27708164
PTPRC LCK â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 7507203 6672875
LCK LCP2 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 10556826 16354835 8702662 21725281
PTPRC LCK â—¼   PHOSPHORYLATION ✅ 0.85 0.85 mint 7507203 6672875
PTPRC LCK â—¼   DEPHOSPHORYLATION ✅ 0.85 0.85 mint 10369126 8310409
LCK PTPRC â—¼   DEPHOSPHORYLATION ✅ 0.85 0.85 mint 7507203 6672875
CD8A CD8B â—¼   PHYSICAL_INTERACTION 851.0 0.85 STRING 36370105
CSK PTPRC â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 19167335 7507203
LCK CDK1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 31980649 34079125
IL2RA IL2 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 17032757 1993646 16477002
CD8A HLAG â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 10843658 1908512 10809759
RELA RELB â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
LCP2 VAV1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
CD247 LCK â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
PIK3R1 SHC1 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
JUN ETS1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 8557686 20195357
JUN RUNX1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11274169 11641401
RBPJ NOTCH1 â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 8176976 21475249
LCK PTPRC â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
CD3D CD3E â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
SHC1 CSK â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10037694 19380743 12048194
1A01 B2MG â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 11502003 1448153 16189514 27649529 8805302
CD8A 1A01 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10809759 9177355
HLAG B2MG â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 9228302 17056715 18332182 12853576 16189514
GRAP2 LAT â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10224278 10021361 16189514
SHC1 IL2RB â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10602027 16189514 8294403
SATB1 CD8B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11937547
CD8A B2M â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15136729 15534202 16551255
CD8B B2M â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15136729 15534202 16551255
1B07 B2MG â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 17057332 27649529 11738047 8624811 33961781 11823531 12244049 10975842 8624812 26186194 8976183 28514442 12853576 16189514 2450918
CD2 IL2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 19398758 19494291 26794910
CD2 CD4 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 19398758 19494291 26794910
CD2 LCK â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 19398758 19494291 26794910
CREM CD247 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16237091
GRAP2 CD28 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 24475931 27927989 10820259
PIK3R1 CD28 â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 6730476 7807015
CD28 CD80 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 7964482 7545666 21982860 1847722 2164219
ETS1 CD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19917777 8356078 9780181
VAV1 CD80 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18295596 15886116 10849438
VAV1 CD86 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18295596 15886116 10849438
GATA3 CD8A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11937547 8413295
ZBTB7B CD8A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19062319 17296789 17878336
GATA3 CD8B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11937547
EOMES PRF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20096607 17566017 23409078
JUN ETS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 1945412 8247540
ETS1 MYB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7848925 8999884
TP53 ETS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15469934 14586398
TBX21 GATA3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17075044 16520391
GFI1 IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9566867 8962093 8441411
HLA-C PTPN6 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 11513144 21339333 9605119
STAT4 IL2RA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10068671 14660657
STAT5A IL2RA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16670309 9541574 8943338
JUN RELB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15596805 17446175
LCK LAT â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 12186560 14523017 16938345 12359715
MAF MYB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9566892
RUNX1 PRKCQ â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20019798 21252065
TP53 RBPJ â—¼   PHYSICAL_INTERACTION 3.0 0.9 ACSN 19836055 24254977 26302407
VAV1 SHC1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9209406 8677749 7539782
STAT4 TBX21 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17575072 19923468
B2M CALR â—¼   PHYSICAL_INTERACTION 916.0 0.91 STRING 36370105
B2M HLA-F â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
CD28 PIK3R1 â—¼   PHYSICAL_INTERACTION 919.0 0.91 STRING 36370105
HLA-B B2M â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 8624811 5220994
CD247 CD3E â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
GRAP2 LCP2 â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
CD247 SHC1 â—¼   PHYSICAL_INTERACTION 931.0 0.93 STRING 36370105
CD3E CD3G â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
B2M CD8A â—¼   PHYSICAL_INTERACTION 936.0 0.93 STRING 36370105
IL2RB IL2RG â—¼   PHYSICAL_INTERACTION 939.0 0.93 STRING 36370105
CD3G CD3E â—¼   PHYSICAL_INTERACTION 0.94 0.94 HIPPIE 9582308 2138083 20890284
IL2RG IL2 â—¼   PHYSICAL_INTERACTION 0.95 0.95 HIPPIE 16477002 10662798 8006584 8049354 22446627 11418623
ID2 TCF3 â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
CD2 LCK â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 9677430 16189514 8551220
CD4 LCK â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
LCP2 GRAP2 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 17235283 5219525
B2M HLA-G â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
B2M HLA-C â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
B2M HLA-E â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
B2M HLA-B â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
B2M HLA-A â—¼   PHYSICAL_INTERACTION 989.0 0.98 STRING 36370105
NOTCH1 RBPJ â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
TRAV19 PTPN6 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 12947224 15358536 18173375 18759926
TRAV19 B2M â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 18037897 26300885 15864273 14764708 20080535 15723809 7542404 21167756 22006319 25703557
TRAV19 CD4 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
TRAV19 LCK â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
TRAV19 PTPRC â—¼   DEPHOSPHORYLATION ✅ 5.0 1.0 Reactome 20346773 23580664 11827988 21543337 2530588
CD4 TRBV12-3 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
TRBV12-3 B2M â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 18037897 26300885 15864273 14764708 20080535 15723809 7542404 21167756 22006319 25703557
TRBV12-3 LCK â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
TRBV12-3 PTPN6 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 12947224 15358536 18173375 18759926
TRBV12-3 PTPRC â—¼   DEPHOSPHORYLATION ✅ 5.0 1.0 Reactome 20346773 23580664 11827988 21543337 2530588
TRAV8-4 B2M â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 18037897 26300885 15864273 14764708 20080535 15723809 7542404 21167756 22006319 25703557
TRAV8-4 PTPN6 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 12947224 15358536 18173375 18759926
CD4 TRAV8-4 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
TRAV8-4 LCK â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
TRAV8-4 PTPRC â—¼   DEPHOSPHORYLATION ✅ 5.0 1.0 Reactome 20346773 23580664 11827988 21543337 2530588
CD4 TRBV7-9 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
TRBV7-9 B2M â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 18037897 26300885 15864273 14764708 20080535 15723809 7542404 21167756 22006319 25703557
TRBV7-9 LCK â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
TRBV7-9 PTPRC â—¼   DEPHOSPHORYLATION ✅ 5.0 1.0 Reactome 20346773 23580664 11827988 21543337 2530588
TRBV7-9 PTPN6 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 12947224 15358536 18173375 18759926
CSK PAG1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 10790433 11181701 12218089 12485116 15713798 19290918 8011291 8986721
CSK LCK â—¼   DOWN_REGULATES ✅ - 7.0 1.0 ACSN 10790433 11181701 12485116 15713798 19290918 8011291 8986721
PAG1 CSK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 23109003 12614359 31125786 10790433
CSK SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 12767520 12048194 18829532 9819392 19380743 10037694 17673906
CSK LCK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 56.0 1.0 Omnipath 20346773 19901323 10692391 11489946 22566970 24463463 2141684 16497976 15592455 20813252 10799545 14967142 27547268 24764511 28522807 16537894 12485116 8193535 24227778 17897955 8183556 22426112 89123626 15489916 14610046 23109003 18691976 28448599 17947241 1639064 12414720 15144186 27460989 24816556 22507872 8631775 15743820 25979654 8945479 11181701 27045023 25595912 15259016
CSK PTPRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 7507203 19167335
SATB1 CD8A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10800076 18722016 11937547 9218488
CD3D B2M â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 18037897 26300885 15864273 14764708 20080535 15723809 7542404 21167756 22006319 25703557
CD3E B2M â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 18037897 26300885 15864273 14764708 20080535 15723809 7542404 21167756 22006319 25703557
TRAV29DV5 B2M â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 18037897 26300885 15864273 14764708 20080535 15723809 7542404 21167756 22006319 25703557
CD3G B2M â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 18037897 26300885 15864273 14764708 20080535 15723809 7542404 21167756 22006319 25703557
TRBC1 B2M â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 18037897 26300885 15864273 14764708 20080535 15723809 7542404 21167756 22006319 25703557
CD247 B2M â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 18037897 26300885 15864273 14764708 20080535 15723809 7542404 21167756 22006319 25703557
TRAC B2M â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 18037897 26300885 15864273 14764708 20080535 15723809 7542404 21167756 22006319 25703557
CALR B2M â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 14508489 16181333 16239148 17204652 20958319 22076556 23157435 23850759
B2M CD247 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 10358761 10559964 11154916 11509172 11717192 14508489 16181333 22076556 22790179 24457417 8642276
B2M PTPRC â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 10358761 10559964 11154916 11509172 11717192 14508489 16181333 22076556 22790179 24457417 8642276
B2M LCK â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 10358761 10559964 11154916 11509172 11717192 14508489 16181333 22076556 22790179 24457417 8642276
B2M HLA-E â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9605335 16189514 10064069 9660937
CD4 TRAC â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
TRAC LCK â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
TRAC PTPN6 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 12947224 15358536 18173375 18759926
TRAC PTPRC â—¼   DEPHOSPHORYLATION ✅ 5.0 1.0 Reactome 20346773 23580664 11827988 21543337 2530588
TRAV29DV5 LCK â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
CD4 TRAV29DV5 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
TRAV29DV5 PTPN6 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 12947224 15358536 18173375 18759926
TRAV29DV5 PTPRC â—¼   DEPHOSPHORYLATION ✅ 5.0 1.0 Reactome 20346773 23580664 11827988 21543337 2530588
CD4 TRBC1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
TRBC1 LCK â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
TRBC1 PTPRC â—¼   DEPHOSPHORYLATION ✅ 5.0 1.0 Reactome 20346773 23580664 11827988 21543337 2530588
TRBC1 PTPN6 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 12947224 15358536 18173375 18759926
CD2 LAT â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 10359122 15998796 16081768 19398758 19494291 26794910
CD59 CD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 16189514 1385156 1377404
CD4 CD247 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
HLA-G CD247 â—¼   PHYSICAL_INTERACTION 29.0 1.0 ACSN 10562324 10925299 11353765 11385609 11438547 11489965 11513144 11875494 11994457 12055234 12731048 12811837 15081523 15778339 16287995 16713974 17100877 20435894 20814939 21059766 22267813 23414611 23508573 24378531 8478617 9603467 9625766 9738502 9751747
HLA-G CD247 â—¼   SHARES_COMPLEX 29.0 1.0 ACSN 10562324 10925299 11353765 11385609 11438547 11489965 11513144 11875494 11994457 12055234 12731048 12811837 15081523 15778339 16287995 16713974 17100877 20435894 20814939 21059766 22267813 23414611 23508573 24378531 8478617 9603467 9625766 9738502 9751747
LCK CD247 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10652356 11062502 12731048 12740575 15536084 17544292 19290918 20814939 21127503 22513334 23620508 8478617 8986721 9438848 9738502 9751747
CD4 CD247 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10398592 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 3263576 8478617 8986721 9438848 9738502 9751747
CD247 TBX21 â—¼   ENZYMATIC_REACTION ✅ 21.0 1.0 ACSN 10358164 10562324 11353765 11449354 12393695 12731048 15081523 15099567 18768831 20814939 21059766 2139103 23414611 24445665 7523143 8344348 8478617 8551221 9603467 9625766 9738502
CD247 SHC1 â—¼   ENZYMATIC_REACTION ✅ 21.0 1.0 ACSN 10358164 10562324 11353765 11449354 12393695 12731048 15081523 15099567 18768831 20814939 21059766 2139103 23414611 24445665 7523143 8344348 8478617 8551221 9603467 9625766 9738502
CD247 IL2 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 10562324 11062502 11353765 11385609 12731048 15536084 20814939 21059766 23414611 8478617 9625766 9738502
CD247 PTPRC â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 12414720 19290918 23620508 23886063 25312647
CD247 LCP2 â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 10562324 10925299 11353765 11438547 11875494 12415267 12731048 12811837 15735648 16713974 17371980 20435894 20814939 21059766 23414611 23508573 23620508 23886063 24378531 7600293 8478617 8642247 9625766 9738502
CD247 LAT â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 10562324 10925299 11353765 11438547 11875494 12415267 12731048 12811837 15735648 16713974 17371980 20435894 20814939 21059766 23414611 23508573 23620508 23886063 24378531 7600293 8478617 8642247 9625766 9738502
HLA-E CD247 â—¼   DOWN_REGULATES ✅ - 12.0 1.0 ACSN 10358164 11015446 11062502 12731048 15120186 15536084 22464172 2731048 8478617 9485206 9486650 9655483
HLA-G CD247 â—¼   DOWN_REGULATES ✅ - 29.0 1.0 ACSN 10562324 10925299 11353765 11385609 11438547 11489965 11513144 11875494 11994457 12055234 12731048 12811837 15081523 15778339 16287995 16713974 17100877 20435894 20814939 21059766 22267813 23414611 23508573 24378531 8478617 9603467 9625766 9738502 9751747
PTPRC CD247 â—¼   DEPHOSPHORYLATION ✅ 5.0 1.0 Reactome 20346773 23580664 11827988 21543337 2530588
CD247 PTPN6 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 12947224 15358536 18173375 18759926
LCK CD247 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 9047237 19229850 23109003 16461343 1706070 1505025 16337488 17979845 8626561
PTPN6 CD247 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 14672952 11238643 23109003
CD86 CD28 â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10477595 11207245 11964292 14764699 15034038 15197224 17513775 20231889 20805416 21220452 22076556 22437870 23390297 24218453 25215878 25384214 7523569 8920882 9359474
CD80 CD28 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11964292 12810107 14764699 15197224 17513775 17629517 18585785 20231889 22437870 23390297 25215878 25582338 26405600 7512027 7523569 9359474
CD28 LCP2 â—¼   ENZYMATIC_REACTION ✅ 23.0 1.0 ACSN 10086337 10209041 10567412 10811803 10982827 11447289 11777939 12175651 12640133 1313950 15197224 15567848 15574420 16582911 16887996 17496910 17673906 19449109 22437870 26552706 7523569 8551221 9359474
CD28 IL2 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 10426994 11907067 1313950 15197224 15536084 16713974 22437870 7523569 9359474
CD28 VAV1 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 10426994 11907067 1313950 15197224 15536084 16713974 22437870 7523569 9359474
LCK CD28 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 7568038 22936936 27460989 16094384 10430626 8992971
CD80 CD28 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 21530327 7964482 22437870 2164219 1847722 23954143 15610849 7545666 21982860 21487479
CD86 CD28 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 21530327 22437870 18205792 23954143 11021528 21931534 21487479 7513726
TCF3 CD38 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21212793 21551245
CD4 CD3D â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
CD3D LCK â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
CD3D PTPN6 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 12947224 15358536 18173375 18759926
CD3D PTPRC â—¼   DEPHOSPHORYLATION ✅ 5.0 1.0 Reactome 20346773 23580664 11827988 21543337 2530588
CD4 CD3E â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
CD3E PTPN6 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 12947224 15358536 18173375 18759926
CD3E PTPRC â—¼   DEPHOSPHORYLATION ✅ 5.0 1.0 Reactome 20346773 23580664 11827988 21543337 2530588
LCK CD3E â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12522270 2470098 15144186 11855827 15592455 16094384 15659558
CD3E PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9312149 11855827 11689561
CD4 CD3G â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
LCK CD3G â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
PTPRC CD3G â—¼   DEPHOSPHORYLATION ✅ 5.0 1.0 Reactome 20346773 23580664 11827988 21543337 2530588
CD3G PTPN6 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 12947224 15358536 18173375 18759926
LCK CD4 â—¼   PHYSICAL_INTERACTION 16.0 1.0 ACSN 10398592 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 3263576 8478617 8986721 9438848 9738502 9751747
CD4 PRKCQ â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10398592 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 3263576 8478617 8986721 9438848 9738502 9751747
CD4 VAV1 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10398592 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 3263576 8478617 8986721 9438848 9738502 9751747
CD4 PTPRC â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10398592 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 3263576 8478617 8986721 9438848 9738502 9751747
MYB CD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11287612 8398978 1347906
RUNX3 CD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 19917777 16034110 23310955 12796513 14500656 24836425 17878336 15034051
STAT4 CD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17339437 15778369 18606704 19324016 17306571 15637551 15087447
ZBTB7B CD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23310955 20544728 21435585 18776907 17296789 17878336 21341258
MAF CD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22875803 21244576 19414776 15495158
GATA3 CD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 24167278 19542428 23310955 19602726 20696860 24813204 18776904 20706986 20809492 20065998 19801513 21341258
CD4 PTPN6 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 12947224 15358536 18173375 18759926
CD4 PTPRC â—¼   DEPHOSPHORYLATION ✅ 5.0 1.0 Reactome 20346773 23580664 11827988 21543337 2530588
CD4 LCK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 16888650 8104794 11854499 8246987 3262426 12601806 17653867 23109003 12007789 16189514 17005671 15489916 15047060
CD80 CD86 â—¼   PHYSICAL_INTERACTION 25.0 1.0 ACSN 10477595 11207245 11964292 12810107 14764699 15034038 15197224 17513775 17629517 18585785 20231889 20805416 21220452 22076556 22437870 23390297 24218453 25215878 25384214 25582338 26405600 7512027 7523569 8920882 9359474
RELA CD86 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10586028 12574356 15949284 19164127 15895390 18929846
HLA-A CD8A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9177355 10809759
HLA-G CD8A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 1908512 10843658 10809759
CD8A LAT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10562325
CD8A LCK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16818755 14500983 8814252
TP53 CDK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 10825186 11593387 12874009 19472317 10514438 11313928 16807237 8270002 17942917 9275177 20395210 11032828 19861536 12889596 19067706
CDK1 RUNX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 25914884 19386523 21059642 17015473 18003885 16046550
CDK1 DNMT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21565170 27220480
CDK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 24173284 12767922 1584757 20661218 26029996 2141171 9467949 17570479 20808790 7862459 11327730 11078726 27726420 8357826 16713569 2156209
CDK1 CUX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11584018 17570479
CREM IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 17056544 23124208 12370343 17237447 22942433 15841182 8622971 10586058 12626549 21976679 9545284 23019580 11238674 15322221
CUX1 STAT5A â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 21330321 14660670 17698633 10935490
ETS1 IL2RB â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 15001984 15111329 15181457 16391805 17615296 21041997 21081489 22608498 9157999
ETS1 TBX21 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 15001984 15111329 15181457 16391805 17615296 21041997 21081489 22608498 9157999
TGFB1 ETS1 â—¼   UP_REGULATES ✅ + 27.0 1.0 ACSN 11133108 11708773 12490555 14557817 15111329 15181457 15252039 15548370 16474430 16607286 16716598 17615296 17934056 18403754 19010789 19109155 19920116 20519943 20644162 21041997 21278795 21900405 21909923 22703233 7594497 9157999 9335507
ETS1 IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 7876544 9780181 24019486
ETS1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12145208 19022222 8649821 10510472
JUN ETS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8557686 20195357
GRAP2 VAV1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11007481 8986718 10395673 9099726
HLA-B PTPN6 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 11513144 11994457 8976179 8986721 9605119 9751747
HLA-E PTPN6 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 10358164 11015446 11062502 12731048 15120186 15536084 22464172 2731048 8478617 9485206 9486650 9655483
TGFB1 ID2 â—¼   DOWN_REGULATES ✅ - 27.0 1.0 ACSN 11133108 11708773 12490555 14557817 15111329 15181457 15252039 15548370 16474430 16607286 16716598 17615296 17934056 18403754 19010789 19109155 19920116 20519943 20644162 21041997 21278795 21900405 21909923 22703233 7594497 9157999 9335507
IL2 IL2RA â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26755705 2965306 6164929 7512720 7521688 8683106 9625766
IL2 IL2RG â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26755705 2965306 6164929 7512720 7521688 8683106 9625766
IL2 IL2RB â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26755705 2965306 6164929 7512720 7521688 8683106 9625766
IL2 IL2RB â—¼   SHARES_COMPLEX 26.0 1.0 ACSN 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26755705 2965306 6164929 7512720 7521688 8683106 9625766
IL2 IL2RA â—¼   SHARES_COMPLEX 26.0 1.0 ACSN 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26755705 2965306 6164929 7512720 7521688 8683106 9625766
IL2 IL2RG â—¼   SHARES_COMPLEX 26.0 1.0 ACSN 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26755705 2965306 6164929 7512720 7521688 8683106 9625766
RELA IL2 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10679398 12133954 12759422 14668329 15079071 15536066 17145890 17404308 17550372 19171876 20138012 21224476 23430059 8383323 8580069 9743347
IL2 TBX21 â—¼   ENZYMATIC_REACTION ✅ 21.0 1.0 ACSN 10807786 11280761 11460167 14660645 15289500 15563472 17301840 1825141 18264787 18758473 19528259 21133840 21232017 22224781 23650441 24699077 24958845 26755705 2965306 6164929 9625766
IL2 STAT4 â—¼   ENZYMATIC_REACTION ✅ 21.0 1.0 ACSN 10807786 11280761 11460167 14660645 15289500 15563472 17301840 1825141 18264787 18758473 19528259 21133840 21232017 22224781 23650441 24699077 24958845 26755705 2965306 6164929 9625766
PTPN6 IL2 â—¼   DOWN_REGULATES ✅ - 34.0 1.0 ACSN 10358138 11447289 11449354 11572860 12138178 12176909 1238444 12393695 12421919 12707331 12773515 12917349 15169881 15240681 15699106 15713798 16204085 19833085 20363967 20435894 21469115 22483603 22513334 22683124 22952938 22955274 25355530 26667266 26755705 27474009 8976179 8986721 9751747 9765283
JUN IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 20557936 12370343 10700231 12884855 8436291 9541574 8397339 1737937 9605137 8683110 21832163 9590239 7989759 9774418 16116194 8473495 8114694 10878360 10320367 9233628 7642615 17097050 7565732 8468462 8660843 7739550 8051409 1740667 19181930
RUNX1 IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17466384 22253733 17377532 21292764
TBX21 IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 24006458 10761931 16275766
RELA IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 7623820 8814256 22427656 9417120 9605137 15477007 9111330 21832163 9135552 8383323 8934574 11035116 7730629 16275766 9737979 19968887 28199730 1604322 15585831 8977179 12027419 18045535 18207244 17179947 23578476 15710339 9233628 11145913
STAT5A IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 9817603 24587342 7479881 8683106 24550509 10022878 8943338 9121484 17911616 22854263 17182565 11435608
IL2 IL2RG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 53.0 1.0 Omnipath 15265897 16477002 10807786 19528259 19833085 7521688 17371980 8049354 15563472 18758473 10662798 15289500 23331499 26755705 8683106 23180781 12095053 11418623 6164929 9625766 24829413 1825141 8006584 16799562 7829965 8568232 10820393 7512720 23650441 20856220 7681595 10849428 22224781 1631559 16212621 21840487 26192618 2965306 8260650 23124025
IL2 IL2RA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 6815536 3095922 15265897 12649439 16477002 15933202 1940342 17032757 15178252 8260650 3116143 8894436 1993646 8580082 8960125
IL2 IL2RB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 8568232 3095922 15265897 16477002 11035066 3098894 15933202 1940342 15178252 8260650 3116143 22446627 8006584 8049354
IL2RB IL2RA â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26755705 2965306 6164929 7512720 7521688 8683106 9625766
IL2RG IL2RA â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26755705 2965306 6164929 7512720 7521688 8683106 9625766
IL2RB IL2RA â—¼   SHARES_COMPLEX 26.0 1.0 ACSN 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26755705 2965306 6164929 7512720 7521688 8683106 9625766
IL2RG IL2RA â—¼   SHARES_COMPLEX 26.0 1.0 ACSN 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26755705 2965306 6164929 7512720 7521688 8683106 9625766
RELA IL2RA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23144749 9135552 11781710 7636248 8430069
IL2RB IL2RA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 8568232 15265897 11886175 15933202 15178252 1545122 8260650 3116143 8006584
IL2RA IL2RG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15933202 15265897 8568232 8260650
IL2RG IL2RB â—¼   PHYSICAL_INTERACTION 36.0 1.0 ACSN 10807786 10820393 10849428 12095053 12811837 14607946 15289500 15563472 16212621 16799562 16815076 17371980 17398124 17459805 1825141 18758473 19528259 19833085 19913445 20007590 20856220 21307131 21840487 22224781 23124025 23650441 24829413 25582338 26755705 2965306 6164929 7512720 7521688 7523571 8683106 9625766
IL2RG IL2RB â—¼   SHARES_COMPLEX 36.0 1.0 ACSN 10807786 10820393 10849428 12095053 12811837 14607946 15289500 15563472 16212621 16799562 16815076 17371980 17398124 17459805 1825141 18758473 19528259 19833085 19913445 20007590 20856220 21307131 21840487 22224781 23124025 23650441 24829413 25582338 26755705 2965306 6164929 7512720 7521688 7523571 8683106 9625766
IL2RB STAT4 â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10820393 12811837 14607946 16212621 16815076 17398124 17459805 19833085 19913445 20007590 20856220 21307131 21840487 23124025 24829413 25582338 7512720 7521688 7523571
PTPN6 IL2RB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 9520455 9973481
LCK IL2RB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 10214954 2047859 10602027 18348982 16189514 12200137
IL2RG IL2RB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 8568232 15265897 7514277 10903799 11886175 8026467 15933202 7681595 15178252 1545122 8260650 16189514 11851401 8006584
IL2RB SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 8294403 8700888 8643566 10602027 16189514 24737791
IL2RB STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16189514 10602027 8631883
IL2RB IL2RG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 8568232 15265897 7514277 10903799 11886175 8026467 15933202 7681595 15178252 1545122 8260650 16189514 11851401 8006584
IL2RG STAT4 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 11418623 12517932 12244150 27774606 12093291 12759422
IL2RG STAT4 â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10820393 12811837 14607946 16212621 16815076 17398124 17459805 19833085 19913445 20007590 20856220 21307131 21840487 23124025 24829413 25582338 7512720 7521688 7523571
JUN MYB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 1527086 8670250 12475180
JUN TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 22859294 17321721 20697347 10348347 12963547 10072388 22353755 18604200
JUN TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 8058069 16327802 16730810 23437118 8183578 16365456 22429882 23936544 15546613 10843986 16978906 23762330 7521696 8631909 12794825
RELA JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18174238 9468519 16713569 10488148
VAV1 LAT â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10077632 10646608 10679059 10714681 10849438 10898494 11080163 11526404 11698448 11754814 11994416 12094222 12165654 12186560 12616499 12626562 12740575 12885870 12917349 14764585 15169881 16887996 19909365 20189481 22513334 22786724 22952938 25355530 25539813 26552706 8189062 8226994 9438848
LAT SHC1 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 10072481 10781611 10811803 11169415 12640133 14764585 16102570 16329184 19494291 19909365 23620508 25137453 7523143 7890616 8649391 8976179 9489702 9535722
LAT LCP2 â—¼   ENZYMATIC_REACTION ✅ 51.0 1.0 ACSN 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483
LCK LAT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16938345 12359715 12186560 27700984
LAT VAV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11368773 23109003 16713569 12186560
LAT PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11368773 9489702 19132916 23109003 16713569 14696041
LCK PRKCQ â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10398592 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 3263576 8478617 8986721 9438848 9738502 9751747
LCK VAV1 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10398592 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 3263576 8478617 8986721 9438848 9738502 9751747
LCK PTPRC â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 10652356 12414720 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 23886063 25312647 3263576 8478617 8986721 9438848 9738502 9751747
LCK PTPN6 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 12947224 15358536 18173375 18759926
PAG1 LCK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 22566970 27045023 14610046 10790433 20813252 24764511
PTPRC LCK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 17145710 19167335 8433999 2141684 9973453 8473339 2141630 12589038 8663450 15085197 2548204 8441403 11259588 15743820 10330160 2530588 10369126 8576115 7507203 11369760 17719247
LCK PRKCQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 22798961 26090489 17548359 10652356
LCK PTPN6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 23071622 8692915 16231973 23109003 14699166 19167335 12459785 12468540 11294838 10574931 7512963 16497976 16189514 14757045 8114715 10488096
LCK SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 74.0 1.0 Omnipath 19901323 20230923 16497976 9121430 15592455 9446569 17389395 18578522 10921922 10482988 10764799 18452278 20068231 18669648 12522270 9685404 10896916 9927207 12237775 8702728 8610109 19651622 9741627 9710204 19664994 17016520 10816433 11075717
LCK PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 8294442 11337495 8246987 14583609 11526404 15032589 23109003 9461588 7504174 8397196 10488096
LCK NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 14583609 23331499 16713569
LCK STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 25885255 34021045 12060651 9813040 12456798 21716071 12970160 10825200 11641791 9573010 31697835 11046040 18250158 22177802 22442148 29228564 11254359 19923221 12879454 14522994 20667852
LCK VAV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 20028078 24332539 898671 16285729 15708849 17050525 15699036 17570479 11005864 10669745 10636924
LCK LCP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 16354835 21725281 8702662 10648627 10556826
LCP2 PRKCQ â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 12640133 19909365 20189481 21536650 22786724 23474202 23620508 24343663 24584089 9765283
LCP2 VAV1 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 12640133 19909365 20189481 21536650 22786724 23474202 23620508 24343663 24584089 9765283
PTPN6 LCP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 8760799 15588985 16189514 9765283 15668918
RBPJ NOTCH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22143792 11404076 12700242 24113181
NOTCH1 RBPJ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 51.0 1.0 Omnipath 23022380 16530044 22143792 25609649 26033182 16530045 21475249 8749394 23103515 16713569 22325781 19907488 23331499 21071413 26496610 18988627 22100894 10637481 26186194 21820430 12644465 10713164 17636029 9032325 12370315 11997524 11390662 19165418 19800882 20028974 30967258 9111040 17284587 17526737
SHC1 PIK3R1 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
TP53 PIK3R1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10321740 19763735 21057544 18661553
PTPN6 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 21780115 11337495 11526404 15032589 9065461 11160222 23109003 22880054 10488096
SHC1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 19531499 8662998 7537361 19380743 8621719 16135792 9541596 16219545 16713569 23397142 19889638
STAT4 PRF1 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 10807786 10961885 11449378 12372421 8683106 8700208 9715265
TBX21 PRF1 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 10761931 12055627 12802010 14614857 15084276 16410834 17440449 18768831 26885856
STAT5A PRF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20096607 15963857 10072525
VAV1 PRKCQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 11956228 23109003 10725744 15802604 14673152 21487479
PTPN6 VAV1 â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 12176909 12773515 12917349 15240681 15713798 22513334 22952938 25355530 26667266 27474009 8976179 8986721 9765283
PTPN6 VAV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 8632004 10592173 16189514
RELA TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 18269916 10348347 11032029 8051093 20061391 15155458 21332394 9890939 21887328
RELA TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19385047 23195252 28148567 14600158 16365456 21255844 15051419
TBX21 RUNX1 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 10761931 12055627 12802010 14614857 15084276 16410834 17440449 18768831 26885856
RUNX3 RUNX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17488194 15688019 19403666
TGFB1 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 12767520 22710166 19010789 16474430 19920116 22943793 17934056 20519943 12809600 21900405 11133108 14557817 15548370 17673906
TP53 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 12732139 10618379 22264233 23706820 14514686 8183578 14761612 16138117 18593586 23063463 8119773
TP53 NOTCH1 â—¼   KO_DOWN_REGULATES ✅ - -1.46 1.45 PKG 28854368