Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
HDAC1 PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18691180 9650586
CREB1 PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7721872 12658356
TP53 PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7915517
TP53 GSK3B â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5216887 14744935
TP53 MTA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23552838 22286760
MTA1 HDAC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23791785 16511565
MTA1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17922032
TCF21 LMO4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
KPNA1 LMO4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
TSEN15 LMO4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SEC24D LMO4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
TINAGL1 LMO4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
LMO4 SMAD9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
LMO4 PITPNB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
LMO4 KIF3B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
LMO4 ITSN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
LMO4 LDB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
LMO4 ZNF675 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
LMO4 DDB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
LMO4 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11751867 12925972
DLG4 VMAC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
GAB1 PTPN11 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 8288622 20308328
SOS1 GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11707404
GAB1 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11707404
CEP170P1 CCDC120 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
CREB1 BRCA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 9926942 6548521
BRCA1 KPNA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5221252 8955125
CCDC120 KRT15 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
COG6 GOLGA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
SMAD4 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 9689110
TP53 CSNK2B â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12393879 11239457
DLG4 GOLGA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
DLG4 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GATA3 ERG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21536859
ESR1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16144913
TP53 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10766163 16713569
ESR1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16144913
IKZF3 FHL3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
FOXO1 MYOD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17717603 17922034
FOXO1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16670091 19289458
GRB2 GAB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5212828 10913131
IL6ST GAB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10068651 23331499
TRAF5 GOLGA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
IKZF3 GOLGA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
TFIP11 GOLGA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
GOLGA2 KANK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8153045 21516116
GOLGA2 TFIP11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
GOLGA2 IKZF3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
PAX3 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
VAV1 GRB2 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
GRB2 PTPN11 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 17993263 15031289
SMAD4 HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10199400 11427533
PPARG HDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21151932 16431920
STAT5B IL6ST â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9169475
SOCS3 JAK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10421843 10064597
JAK2 SOS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9209406 8400282
STAT5B JAK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17255200 11682625
KRTAP11-1 TRIM54 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 31391242 233395
SSBP4 LDB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
SSBP2 LDB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
SMAD4 MYOD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
PPARG MYOD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16838108 11477074
SMAD4 PIAS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
PIAS1 PPARG â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 16127449 20711444
PIAS3 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16189514 14691252
PLK1 TP53 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 7266226 19833129
SMAD9 SMAD4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
TINAGL1 SMAD9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
DES KRT33B â—¼   PHYSICAL_INTERACTION 0.8 0.8 HuRI 32296183
JAK2 PTPN11 â—¼   PHYSICAL_INTERACTION 801.0 0.8 STRING 36370105
KRT38 LMO4 â—¼   PHYSICAL_INTERACTION 0.8 0.8 HuRI 32296183
CREB1 TP53 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
LMO4 PELO â—¼   PHYSICAL_INTERACTION 0.8 0.8 HuRI 32296183
LMO4 ZMYND12 â—¼   PHYSICAL_INTERACTION 0.8 0.8 HuRI 32296183
LMO4 SUOX â—¼   PHYSICAL_INTERACTION 0.81 0.81 HuRI 32296183
DDB1 HDAC1 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 24249678 26679995 25189618 34026424
JAK1 SOCS3 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 10373548 10707961
IL6ST JAK2 â—¼   PHYSICAL_INTERACTION 814.0 0.81 STRING 36370105
KRT33B LMO4 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HuRI 32296183
CTBP1 LMO4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 11751867 16713569
ID3 LMO4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HuRI 32296183
LMO4 LHX4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 35140242 24981860
ESR1 CTBP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 23403292 31527615
ESR1 GRHL2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 23403292 26153859
IKZF3 HDAC2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30760870 12015313
LMO4 METTL27 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HuRI 32296183
LMO4 N4BP3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HuRI 32296183
LDB1 LMO4 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
SSBP2 LMO4 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194 24981860
SSBP4 LMO4 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
COM1 LMO4 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 11751867 25416956 12925972 26387952
BANP HDAC1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 25086032 20075864
PLK1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 31730000 25483079 29656893 24067368
LHX4 SMAD4 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
SSBP4 SSBP3 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 30833792 24981860 26186194 28514442
ZNF213 ZNF397 â—¼   PHYSICAL_INTERACTION 830.0 0.83 STRING 36370105
AARD LMO4 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HuRI 32296183
BRCA1 RBBP8 â—¼   UBIQUITINATION ✅ + 0.83 0.83 Signor 16818604
RBBP8 BRCA1 â—¼   RELOCALIZATION ✅ + 0.83 0.83 Signor 24832651
ESR1 TP53 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
ESR1 MTA1 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
KATNBL1 LMO4 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HuRI 32296183
KRTAP11-1 LMO4 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HuRI 32296183
KRTAP3-1 LMO4 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HuRI 32296183
LHX4 QRICH1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HuRI 32296183
MTA1 TP53 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
JAK2 STAT5B â—¼   PHOSPHORYLATION ✅ + 0.84 0.84 Signor 9575217
CRYBB2 LMO4 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HuRI 32296183
ID3 TCF4 â—¼   PHYSICAL_INTERACTION 848.0 0.84 STRING 36370105
MTA1 HDAC2 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 6613464 18451879
SSBP3 LMO4 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 33961781 30833792 24981860 26186194 28514442
SSBP3 LHX4 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 33961781 35140242 30833792 24981860
MYOD1 TCF21 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HuRI 32296183
LMO4 SMAD4 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HuRI 32296183
JAK2 BRCA1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 16713569 11163768
JAK1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 16713569 11163768
HGS DLG4 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 16713569 12151521
ID3 MYOD1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 9242638 8759016
LHX4 SSBP2 â—¼   PHYSICAL_INTERACTION 864.0 0.86 STRING 36370105
BANP TP53 â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
GSK3B TP53 â—¼   PHYSICAL_INTERACTION 866.0 0.86 STRING 36370105
VMAC BANP â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 26186194 32296183
PIAS1 ESR1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 31527615 11117529 15666801
LDB1 LHX8 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 25416956 35140242 32296183
SSBP4 LHX4 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 35140242 26186194
SSBP2 LHX4 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 35140242 24981860 26186194 28514442
SSBP4 LHX8 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 35140242 26186194
IDI2 LMO4 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
KRT39 LMO4 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
LMO4 RSPH6A â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
HDAC2 TP53 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
PIAS1 TP53 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
ERCC6L PLK1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
SSBP3 SSBP4 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
DES LMO4 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
SSBP2 SSBP4 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
IDI2 LDB1 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
ESR1 HDAC1 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
IDI2 SSBP3 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
KRT38 KRT76 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
KRT76 LMO4 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
KRT34 SUOX â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
DES KRT75 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
IDI2 SSBP2 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
BCAS2 LMO4 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
KRT40 SUOX â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
IL6ST PTPN11 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
IL6ST JAK1 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
CTBP1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11751867 10196224 16713569 21102443 31636387
ESR1 GATA3 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 26153859 23403292 25303530
GATA3 HDAC2 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 29453984 26028330 31409898
JAK1 GRB2 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 8536716 11527382
IL6ST SOCS3 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
PIAS3 SMAD4 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 14691252 16189514
LMO4 ZNF467 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HuRI 32296183
LMO4 SSBP2 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
LMO4 SSBP3 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
LMO4 SSBP4 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
SSBP2 SSBP3 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
KRT75 LMO4 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HuRI 32296183
BCAS2 KRT75 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HuRI 32296183
FHL3 QRICH1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HuRI 32296183
KRT39 KRT74 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HuRI 32296183
KRT40 KRT76 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HuRI 32296183
CTBP1 COM1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 9535825 10196224 26807646 16287852 31636387
HDAC1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10220405 21102443 16713569
HDAC2 BRCA1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 21946536 10220405 16713569
HDAC2 CTBP1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 17967884 11022042 18212045 16713569 10766745 28947780 31041561 16036112
FOXO1 ESR1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 11435445 11353774 22266855
GATA3 HDAC1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 34026424 29453984 26028330 31409898
PTPRE GRB2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 28330616 27880917 33961781 10490839
KRT39 KRT76 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
LHX4 LDB1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 35140242 32296183 24981860 26186194 28514442
SSBP3 LDB1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 12381786 28514442 33961781 32296183 30833792 24981860 26186194 25416956 26495868
FHL3 LMO4 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
PTPN11 SOS1 â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
PLK1 ERCC6L â—¼   RELOCALIZATION ✅ + 0.89 0.89 Signor 17218258
KRT40 KRT75 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
GRB2 VAV1 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
KRT75 KRT76 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
LMO4 UBQLN2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
EXOSC8 LMO4 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
KRT31 KRT76 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
LDB1 LHX4 â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
KRT31 LMO4 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
KRT38 KRT74 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
HDAC1 PCNA â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 14988403 11929879 16189514 16713569
PPARG PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17389773 14764597 19673929
LMO4 GSK3B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
ZNF135 GSK3B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MTA1 HDAC1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 21670149 34026424 24981860 16511565 22939629 26496610 9885572 27098840 26344197 21258344 10840944 14722073 26028330 12920132 33264408 17922035 28514442 16189514 26949739 18451879 11146623 23752268 20585571 29997244
MTA1 ESR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 18451880 16807247 12167865 11146623 12639951 31527615
CSNK2B LMO4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
TNFSF11 LMO4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
LMO4 BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11751867 12925972 16713569
LMO4 GADD45A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
LMO4 RPS6KA6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
LMO4 PLK1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
JAK2 GAB1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15644415 12506011 10455108
BRCA1 COM1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 10764811 29513652 11689934 18285836 10910365 16843262 26387952 19369211 29656893 17525342 31636387 31932421 9738006 25252691 30257991 16818604 25659039 21908405 25310973 19452558 14578343 10196224 17525340 23416467 9811458 34408138 22231403 27454289 11739404 28132842 20351172 24085845 26446986 15485915 25184681 18171670 28398198
GATA3 ARNT2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19559773
ESR1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11493692 27977889 10334989 11782371 16713569 17505062 15674350 19887647 20060929 11244506 16860316 17392432 31527615 16061635 16260778 12400015 1244506 25499220 29367421
BRCA1 TP53 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
BRCA1 ESR1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
ITSN1 CSNK2B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
HDAC1 CTBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9650586 16713569
TP53 DDB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16357511 19382146
ESR1 ECM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20034404
STAT5B ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11731618 11682625
ESR1 SOCS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16055089 18414489
FOXO1 GADD45A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20088826 17599040 15632117
GADD45A TP53 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
JAK2 GRB2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 8536716 17474147 8950973 7500025
JAK1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8536716 11527382
GRB2 IKZF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 32296183 25416956 27107012
PLK1 ITSN1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
SOCS3 JAK2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 10421843 9344848 14517242 15514089 29752723 22342841 24438103 10882725 24354892 11314018 19543316
MITF PIAS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21519923 19201870 16368885
TP53 PIAS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 24584189 11877452
TNFSF11 PLK1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
PPARG TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16887883 14960510
STAT5B SOCS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10821852 16306356 10359822
KRT31 KRT75 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HuRI 32296183
GADD45A PCNA â—¼   PHYSICAL_INTERACTION 903.0 0.9 STRING 36370105
JAK2 SOCS3 â—¼   PHYSICAL_INTERACTION 903.0 0.9 STRING 36370105
LMO4 MYOD1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HuRI 32296183
KRT33B KRT75 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HuRI 32296183
KRT38 KRT75 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HuRI 32296183
GRB2 SOS1 â—¼   RELOCALIZATION ✅ + 0.9 0.9 Signor 23452850
GAB2 PTPN11 â—¼   PHYSICAL_INTERACTION 907.0 0.9 STRING 36370105
KRT34 LMO4 â—¼   PHYSICAL_INTERACTION 0.91 0.91 HuRI 32296183
KRT31 KRT74 â—¼   PHYSICAL_INTERACTION 0.91 0.91 HuRI 32296183
LDB1 SSBP4 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
SUOX UBQLN2 â—¼   PHYSICAL_INTERACTION 0.91 0.91 HuRI 32296183
BCAS2 KRT31 â—¼   PHYSICAL_INTERACTION 0.92 0.92 HuRI 32296183
BCAS2 KRT34 â—¼   PHYSICAL_INTERACTION 0.92 0.92 HuRI 32296183
LMO4 VMAC â—¼   PHYSICAL_INTERACTION 0.92 0.92 HuRI 32296183
KRT34 KRT74 â—¼   PHYSICAL_INTERACTION 0.92 0.92 HuRI 32296183
JAK2 STAT5B â—¼   PHYSICAL_INTERACTION 926.0 0.92 STRING 36370105
HDAC1 TP53 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
TP53 FHL3 â—¼   KO_DOWN_REGULATES ✅ - -0.93 0.93 PKG 28854368
KRT34 KRT75 â—¼   PHYSICAL_INTERACTION 0.93 0.93 HuRI 32296183
LDB1 SSBP3 â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
GRB2 PTPN11 â—¼   PHYSICAL_INTERACTION 949.0 0.94 STRING 36370105
SMAD4 SMAD9 â—¼   PHYSICAL_INTERACTION 950.0 0.95 STRING 36370105
HDAC2 MTA1 â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
PTPN11 GAB1 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 6169284 14701753
PTPN11 GAB1 â—¼   DEPHOSPHORYLATION ✅ 0.96 0.96 mint 20308328 8288622
PIAS3 MITF â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 11709556 16189514 16029420
HDAC2 HDAC1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 33961781 21670149 24981860 22939629 26496610 11102443 11919195 11777905 30737378 9885572 22416134 26344197 21258344 9804427 12493763 11287668 16713569 11466315 12920132 20388487 9790534 10581039 11739383 15987735 17894944 19182791 9150135 28514442 26949739 19041848 10444591 19703393 11804585 25241761 17956988 11564889 12032298 15451426 15297431 23752268 18059533 9520398
GAB2 GRB2 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
BRCA1 RBBP8 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
LDB1 SSBP2 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
HDAC1 MTA1 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
GAB1 GRB2 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GAB1 PTPN11 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GRB2 SOS1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PCNA GADD45A â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 10779360 11756412 12124778 14624239 14726013 15703371 15917306 16697054 17599061 19004803 19652693 1974050 19847258 20457011 22021614 22615860 23414611 23485469
PCNA DDB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
PCNA BRCA1 â—¼   PHYSICAL_INTERACTION 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
PCNA BRCA1 â—¼   SHARES_COMPLEX 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
PCNA GADD45A â—¼   REGULATES ✅ 18.0 1.0 ACSN 10779360 11756412 12124778 14624239 14726013 15703371 15917306 16697054 17599061 19004803 19652693 1974050 19847258 20457011 22021614 22615860 23414611 23485469
TP53 PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 10321841 7915517 15358233 12217864 10516009 1705714 8570655 16980608 9707425 15950182 19789303 11313928 1356162 12384701 9858527 12947108 23390122 8524244 9651310 1352831 7909518 11032828 10910968 12485898 10618724
GADD45A PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 7784094 23485469 10973963 7973727 10828065 16189514 20460379 7478510
GSK3B TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 23840442 12064478 11709713 9372954 11483158 16552184 17570479 14744935 16713569 21929745 12048243 21900206
GSK3B ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 10428798 10949034 17609434 15461668 9528769 12118371 15059947 16076840 17570479 7491495 12093745 8308015 15212693 15528270 7838153
GSK3B CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 16568235 12162494
MTA1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15226262 11146623 12527756 24413532
MTA1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11146623 18451880 12167865 16807247
LMO4 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 11751867 16713569 12925972
GRB2 GAB1 â—¼   PHYSICAL_INTERACTION 50.0 1.0 ACSN 10086337 10514377 10567412 10648629 10811803 10982827 11062502 11313945 11385609 11447289 11777939 11907067 11940581 12040186 12175651 12419216 12640133 12670391 12782630 14585353 15199124 15534002 15536084 15567848 15574420 15584861 15863030 16102570 16227978 16488589 16582911 16847462 16887996 17496910 17635922 17673906 18287025 19449109 19568798 19615955 20805416 21102635 23523669 24027568 26552706 27111285 7510700 8294866 8551221 9779982
GRB2 GAB1 â—¼   SHARES_COMPLEX 50.0 1.0 ACSN 10086337 10514377 10567412 10648629 10811803 10982827 11062502 11313945 11385609 11447289 11777939 11907067 11940581 12040186 12175651 12419216 12640133 12670391 12782630 14585353 15199124 15534002 15536084 15567848 15574420 15584861 15863030 16102570 16227978 16488589 16582911 16847462 16887996 17496910 17635922 17673906 18287025 19449109 19568798 19615955 20805416 21102635 23523669 24027568 26552706 27111285 7510700 8294866 8551221 9779982
GRB2 GAB1 â—¼   ENZYMATIC_REACTION ✅ 50.0 1.0 ACSN 10086337 10514377 10567412 10648629 10811803 10982827 11062502 11313945 11385609 11447289 11777939 11907067 11940581 12040186 12175651 12419216 12640133 12670391 12782630 14585353 15199124 15534002 15536084 15567848 15574420 15584861 15863030 16102570 16227978 16488589 16582911 16847462 16887996 17496910 17635922 17673906 18287025 19449109 19568798 19615955 20805416 21102635 23523669 24027568 26552706 27111285 7510700 8294866 8551221 9779982
GRB2 GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 47.0 1.0 Omnipath 12766170 21706016 9242692 10913131 11445578 22536782 8596638 11027663 10592173 20936779 11960376 15010462 19523899 20005866 19380743 10871282 9804835 14685170 11314042
PTPN11 GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 72.0 1.0 Omnipath 14701753 18577518 17145710 11453982 12582165 20308328 14665621 8596638 14982882 20473329 11027663 10592173 10788507 9658397 12024020 10068651 24728074 11134009 10194437 12855672 21442024 11323411 11940581 15574420 11278704 10871282 9804835 9632795
MITF BIRC7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19067971 1999537 18451137 23480510
CTBP1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20818429 21681822 23303449
TP53 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 9582019 11295099 18625847 11003642 12802282 16357511 14710355 9619832 19882681 10884389 11384963 11782367 12024039 15735697 12170778 21245169 17993233 12549011 11431698 16229810 18208621 10597265 21742769
CREB1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9528858 19882681 18160048 23447579 11704836
BRCA1 GADD45A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17428466 11777930 10962562 18025037 18350249 12647291
BRCA1 RBBP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 21908405 18285836 16713569 15485915 25310973 9738006 17525342 17525340 16843262 24085845 25184681 26387952 18369654 9811458 16818604 20351172 23416467 19442256 10196224 10910365 19452558 11739404 25252691 10764811 25659039 17965729 11689934
BRCA1 GADD45A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 12771027 9346961 10779360 11877377 10367887 19004803 21060331 12496474 19793801 15650754 10962562 21337561 9892649 10528224 15459660 20029420
BRCA1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11244506 12400015 15674350 10334989 16713569 11493692
CREB1 MITF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 19937254 10841026 17083486 22496449 19067970 18039926 21519923 16327152 24267286
CREB1 TNFSF11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12364326 23439434 19880655 16914731 17053039 15731115
CREB1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16611888 25241761 21295542
CSNK2B TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 10606744 11709713 10214938 10951572 16713569 11551930 10747897 10673501 11883897
MYOD1 DES â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17950683 9497371 8382796 8062833 9502427 8276797 25653159
PLK1 ERCC6L â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17218258 22527115 20360068
GATA3 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17616709 20130088 20068169
HDAC1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 21655924 23242655 18316616 20101232
ESR1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 20080630 16115928 22787161 12750288 20696891 17681750 17699779
PIAS1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15666801 11117529
ESR1 GATA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 26153859 25303530 10096242
ESR1 FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 17145710 18391971 22266855 11435445 11353774
FOXO1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16670091 12966085 17317207
STAT5B GAB2 â—¼   PHYSICAL_INTERACTION 14.0 1.0 Reactome 16627759 22411868 11090077 26515730 20111072 15498859 10698507 12468433 12796379 30552988 23103841 31066629 15003515 17356133
PTPN11 GAB2 â—¼   PHYSICAL_INTERACTION 15.0 1.0 ACSN 10358138 10849428 10982827 11447289 11572860 12138178 12640133 12707331 15240681 15699106 15713798 16212621 19833085 19909365 9751747
GRB2 GAB2 â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 10086337 10358164 10567412 10811803 10849428 10982827 11447289 11449354 11777939 12175651 12393695 12640133 15567848 15574420 16076871 16212621 16582911 16887996 17496910 17673906 19449109 19909365 26552706 8551221 9763606
PTPN11 GAB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 44.0 1.0 Omnipath 17145710 11287610 15356145 12135708 10391903 19172738 23331499 14982882 11334882 11027663 21636860 10973965 19909739 11812650 10068651 11572860 15170389 9885561 15010462 18950707 16253990 18725415 10871282 11782427
GRB2 GAB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 17145710 16371368 25416956 21706016 15143164 10391903 19172738 10913131 11027663 9973481 10973965 20936779 10068651 11882361 32296183 16199887 24737791 15010462 19523899 16253990 19380743 31515488 11782427
JAK2 GAB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18644434 21183952
TP53 GADD45A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 10749144 22801474 11221850 15031557 22262183 10321740 17700520 11420680 10094833 23114628 8892753 23948959 9405685 21394211 9931282 10435630 12007564 15721278 17440969 23576563 9566896 9233781 21836608 21245169 15186775 17063488 9154806 10327059 9191059 17344317 9519881 20797428 18350249 7624148 10566557 17084916 16714289 20840860 15735726 12806965 18225552 16581545
TP53 GADD45A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16990795 15603758 14627995
GATA3 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 18522800 15632071 15896659
PLK1 GOLGA2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 12839990 20937827 15678101 11447294
SEC24D GOLGA2 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 10903204 11306556 23378591 9150144 10679020 11285137 23698585 11927603 16624868
STAT5B GRB2 â—¼   PHYSICAL_INTERACTION 14.0 1.0 Reactome 16627759 22411868 11090077 26515730 20111072 15498859 10698507 12468433 12796379 30552988 23103841 31066629 15003515 17356133
HGS GRB2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 24828152 12686592 12551915 15828871 19109251
SOS1 GRB2 â—¼   PHYSICAL_INTERACTION 1.0 1.0 HIPPIE 8810325 33961781 8695800 7510700 8626525 34407391 16520382 10570290 16906159 16893902 7642581 8816480 9447984 12577067 11964172 8112292 8493579 7664271 16713569 7516467 19380743 9009162 10207103 17474147 10477741 32062451 7629138 21706016 20473329 19323566 9872323 32203420 7514169 21988832 28166272 28514442 9716598 11997436 9344843 15192046 10716926 8479541 14679214 8943292 31980649 7629168 7559490 9478994 7527391 8188688 11960376 10025673 11726515 7773779 10319320 9569023 9797459
PTPN11 GRB2 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 10358138 11447289 11572860 12138178 12707331 15240681 15699106 15713798 19833085 9751747
GRB2 VAV1 â—¼   ENZYMATIC_REACTION ✅ 57.0 1.0 ACSN 10077632 10086337 10426994 10567412 10646608 10679059 10714681 10811803 10849438 10898494 10982827 11080163 11447289 11526404 11698448 11754814 11777939 11777960 11907067 11994416 12094222 12165654 12175651 12186560 12616499 12626562 12640133 12740575 12885870 12917349 14764585 15169881 15536084 15567848 15574420 16339513 16582911 16713974 16887996 17070508 17100878 17496910 17673906 18490724 19449109 19909365 20189481 22513334 22786724 22952938 25355530 25539813 26552706 8189062 8226994 8551221 9438848
GRB2 MAP2K6 â—¼   ENZYMATIC_REACTION ✅ 34.0 1.0 ACSN 10086337 10567412 10811803 10982827 11274345 11447289 11777939 12040186 12175651 12419216 12640133 12738796 12782630 14585353 15567848 15574420 15863030 16102570 16227978 16488589 16582911 16887996 17496910 17673906 18855897 19449109 19568798 19615955 21102635 21614932 24027568 26552706 7510700 8551221
JAK2 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8536716 8950973 7500025 17474147 19273609
VAV1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 8900182 10207103 9013873 15558030 7651724 7809090 8621483 29997244 18692475 7478592 16713569 11406576 9209406 16339550
IL6ST GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 7963520 9013873
PTPN11 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 66.0 1.0 Omnipath 8702859 9361008 16371368 21706016 8041791 11085989 8978300 11432792 15882975 9362449 10212213 11684012 7523381 10592173 16189514 10747947 10973965 9632781 8959326 11602579 12577067 9254654 10080542 15010462 31585087 12531430 8995399 19380743 7522233 9804835 7534299 9824671 9660791
GRB2 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 145.0 1.0 Omnipath 9544989 9872323 7642581 15746962 11726515 8621483 23334917 16520382 11997436 21706016 10359574 8950973 7664271 16713569 16893902 16906159 21988832 19323566 9009162 10716926 11964172 7629168 9815779 10592173 9716598 8647802 28166272 7773778 7773779 18778683 8188688 10319320 8810325 9344843 23452850 11960376 8816480 10025673 7510700 8940013 12955078 9697839 12345678 10477741 8493579 8943292 12577067 7862167 9199344 8112292 7898932 10207103 8695800 19531499 10570290 7760801 20005866 19380743 9447984 8235613 8479540 7527391 14679214 8479541 17474147 7514169 7629138
HDAC1 HDAC2 â—¼   PHYSICAL_INTERACTION 28.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21685935 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 HDAC2 â—¼   SHARES_COMPLEX 28.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21685935 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 HDAC2 â—¼   UP_REGULATES ✅ + 28.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21685935 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 MYOD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16713569 20124407 11684023 11285237
HDAC1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 17145710 10521394 11099047 22266186 20633551 18765668 20075864 17827154 11313951 14976551 25241761 19303885 12426395 19011633 16697957 16959611 16107876 10777477
ID3 TCF4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 11591653 25609649 9242638 25416956 8999959 16189514
JAK2 IL6ST â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 8390097 9238703 16051226 11943154
JAK1 IL6ST â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 8390097 9238703 16051226 11943154
SOCS3 IL6ST â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 10777583 30591653 12403768 24710148 19620279 23454976 10946280
IL6ST JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 7896787 23331499 11468294 9388212 21220115 24710148 11742534 23663276 12487370
IL6ST VAV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9013873
IL6ST JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 7896787 8174677 9716487
IL6ST PTPN11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 9632795 12040451 12403768 9195977 8978300 10946280
JAK1 JAK2 â—¼   PHYSICAL_INTERACTION 92.0 1.0 ACSN 10485906 11160275 11306493 11371360 11489965 11579131 11777960 11867689 11870632 11964313 12223527 12401408 12413632 12496409 12754507 12811837 12818165 1439146 14607900 14610620 14657224 15099563 15356132 15573129 15634932 15778339 15811952 15814715 16243976 16286920 16413922 16424049 16713974 17016554 17404308 17485448 17559085 17683974 18209571 18250477 1825141 18272812 18451175 18555777 18555778 19581928 19833085 20038811 20138012 20184663 20237318 20406969 20510870 20581311 20819927 20856220 21097505 21115385 21149606 21411734 21469115 21840487 22595692 22754783 23034983 23124025 23390297 23567181 24011634 24030977 24091328 24346288 24418198 24658051 25002027 25582338 26201938 26268945 26755705 27216177 27557510 2965306 6425450 7512720 7521688 7543512 7590867 8837607 9535722 9834059 9845545 9864217
JAK1 JAK2 â—¼   SHARES_COMPLEX 92.0 1.0 ACSN 10485906 11160275 11306493 11371360 11489965 11579131 11777960 11867689 11870632 11964313 12223527 12401408 12413632 12496409 12754507 12811837 12818165 1439146 14607900 14610620 14657224 15099563 15356132 15573129 15634932 15778339 15811952 15814715 16243976 16286920 16413922 16424049 16713974 17016554 17404308 17485448 17559085 17683974 18209571 18250477 1825141 18272812 18451175 18555777 18555778 19581928 19833085 20038811 20138012 20184663 20237318 20406969 20510870 20581311 20819927 20856220 21097505 21115385 21149606 21411734 21469115 21840487 22595692 22754783 23034983 23124025 23390297 23567181 24011634 24030977 24091328 24346288 24418198 24658051 25002027 25582338 26201938 26268945 26755705 27216177 27557510 2965306 6425450 7512720 7521688 7543512 7590867 8837607 9535722 9834059 9845545 9864217
JAK1 STAT5B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16741510 10781830 9047382
JAK1 PTPN11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23331499 8790359 21071413 8995399 12270932 12403768 9794795 11036942
JAK1 SOCS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 25682267 10950967 16459330 10707961 10373548
SOCS3 JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 10882725 10421843 23331499 10514492 19543316 21071413 29752723 10551777 24438103 24354892 11314018 15514089 24600449 22342841 18988627 9344848
JAK2 PTPN11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 8912646 23331499 21071413 7559603 8995399 9794795
JAK2 STAT5B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23331499 9047382 21071413 12538627 26959975 24354892 16306356 18988627 12456798 9575217 11682625
PAX3 MITF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 10982026 22290434 10480898 19074888 19403660 9500554 19026785 20925909 11237412 10942418 10644012 21965087 21519923 11830592
MITF TNFSF11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17105730 24257758 19321441 23379601 20357005
PIAS3 MITF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 16189514 11709556 16029420
PAX3 MYOD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 20605921 11262400 10529415 20978076 18508329 18854138 14732408
PIAS1 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 14514699 21988832 23331499 15028714 15231748
PIAS1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 25241761 15133049 10380882 20805487 11867732 16713569 11583632 11788578
TP53 PLK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 17172872 17981789 15024021 22405092 20962589 24076372 23948487 15016801 22184120 19713933 16369493 23474762
PLK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 22653443 19833129 16753148 23948487
SMAD4 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21836474 21926264 16580992 12524424
SOCS3 PTPN11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 12403768 17138568 11356008 10777583
PTPN11 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12577067 9632781 9344843
PTPN11 STAT5B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 10617656
SMAD9 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20957627 25502805 10583507 31515488 16189514 15231748
VAV1 SOS1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11007481 8986718 10395673 9099726