Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
ZRANB1 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19373254 7288828
UBC ZRANB1 â—¼   DEUBIQUITINATION ✅ 2.0 0.8 intact 19373254 7288828
CSK PTPN11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18173375 18759926
CSK PTPN11 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 15574420 14665621
ABCE1 RPL11 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
DCTN3 ACTR10 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15473859 15738427
DCTN3 ACTR1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15473859 15738427
BTRC AURKA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17939994 0706493104
AURKA HDAC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17604723
BRAF PPP5C â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 16892053 21779496
PAK2 BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20936779
DCTN1 HDAC6 â—¼   COLOCALIZATION 2.0 0.8 intact 5215415 12024216
PRPSAP1 DDX19B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
EEF1A2 TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
PPP2R1A EEF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8208439 17540176
ETF1 RPL11 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
FBXW11 YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22017875 21900206
FEN1 RECQL â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
PAFAH1B1 HSP90AA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20133715 0914307107
HSP90AA1 PAFAH1B1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20133715
IPO7 TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
UBA1 OTUB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
UBC OTUB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11689694 5214752
OTUB1 TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19996094
PDIA6 USP47 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
PPP2R1A PTPN11 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 17993263 15031289
RIC8A TUBB2A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
TUBB TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
UBE2V1 TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1551980 11057907
UBA6 UBC â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
UBC YBX1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218767 16797541
URM1 USP47 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1014402108 21209336
MAPK14 MAPKAPK2 â—¼   PHOSPHORYLATION ✅ + 0.8 0.8 Signor 14499342
ACTR1A DCTN3 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
EIF4A1 RPS2 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
DCTN1 DCTN4 â—¼   CORRELATES + 0.8 0.8 CCLE 31978347
AP3B1 AP3M2 â—¼   CORRELATES + 0.8 0.8 CCLE 31978347
TUBB4B UBE2V1 â—¼   CORRELATES + 0.8 0.8 CCLE 31978347
OTUB1 TRAF6 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 20622874 34591986 19996094
BTRC USP47 â—¼   PHYSICAL_INTERACTION 811.0 0.81 STRING 36370105
AP3D1 AP3M2 â—¼   CORRELATES + 0.81 0.81 CCLE 31978347
POLB SATB1 â—¼   KO_DOWN_REGULATES ✅ - -0.82 0.81 PKG 28854368
DCTN3 DCTN4 â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
TUBB2A TUBB4B â—¼   PHYSICAL_INTERACTION 819.0 0.81 STRING 36370105
AP3M2 AP3B1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
AP3M2 AP3D1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
AP3M1 AP3M2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
DENR UBC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 16874301 16936636
USP9X YAP1 â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
TUBB2A TUBB4B â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
MAPK14 MAPKAPK2 â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
ACTR1A DCTN4 â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
EEF2 ETF1 â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
PPP5C HSP90AA1 â—¼   PHYSICAL_INTERACTION ✅ 0.83 0.83 mint 27880917
ACTR10 DCTN3 â—¼   PHYSICAL_INTERACTION 834.0 0.83 STRING 36370105
BRAF MAPK1 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
GSPT1 RPS2 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
GSPT1 RPL11 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
PRMT3 RPS2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HuRI 32296183
ACTR10 DCTN1 â—¼   CORRELATES + 0.84 0.84 CCLE 31978347
RABGGTB YKT6 â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
ETF1 RPS2 â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
KIF5B TUBA1B â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
TUBA1B TUBB4B â—¼   CORRELATES + 0.84 0.84 CCLE 31978347
ACTR10 DYNC1H1 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
AGO2 HSP90AA1 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
ACTR1A DCTN3 â—¼   CORRELATES + 0.85 0.85 CCLE 31978347
KIF5B TUBB2A â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
BTRC UBC â—¼   PHYSICAL_INTERACTION 859.0 0.85 STRING 36370105
DENR RPS2 â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
AP3M1 AP3D1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 23144738 26344197 28514442 22863883
EIF4A1 EIF4A2 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
AP3D1 AP3M1 â—¼   CORRELATES + 0.87 0.87 CCLE 31978347
BTRC FBXW11 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
MAPK1 MAPK14 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
FBXW11 USP47 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
TUBB TUBB2A â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
PPP2R1A PPP2R4 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
TUBB3 TUBB4B â—¼   CORRELATES + 0.87 0.87 CCLE 31978347
TRAF6 ZRANB1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
AP3B1 AP3M2 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
ACTR10 ACTR1A â—¼   CORRELATES + 0.87 0.87 CCLE 31978347
RPRD1A RPRD1B â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
TUBB TUBB2A â—¼   CORRELATES + 0.88 0.88 CCLE 31978347
BTRC YAP1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
HDAC6 HSP90AA1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
ABCE1 NAA15 â—¼   CORRELATES + 0.88 0.88 CCLE 31978347
PDCD6IP TSG101 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
TRAF6 UBE2V1 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
AP3B1 AP3M1 â—¼   CORRELATES + 0.89 0.89 CCLE 31978347
AP3B1 AP3D1 â—¼   CORRELATES + 0.89 0.89 CCLE 31978347
DCTN1 DCTN3 â—¼   CORRELATES + 0.89 0.89 CCLE 31978347
BRAF MAPK1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16508002 14654779 19933846
YAP1 BTRC â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
DCTN4 DCTN1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 27173435 26344197 28718761 26638075 28514442 34079125
MAPK1 MAP2K2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 10567369 19219045 8013650
NCF2 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16778989 10400704 27558335
ACTR1A DCTN1 â—¼   CORRELATES + 0.9 0.9 CCLE 31978347
ACTR1A DYNC1H1 â—¼   PHYSICAL_INTERACTION 907.0 0.9 STRING 36370105
MAPK1 MAPKAPK2 â—¼   PHYSICAL_INTERACTION 909.0 0.9 STRING 36370105
ACTR10 DCTN1 â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
TRAF6 UBC â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
TUBB TUBB3 â—¼   CORRELATES + 0.91 0.91 CCLE 31978347
TUBA1B TUBB â—¼   CORRELATES + 0.91 0.91 CCLE 31978347
AP3D1 AP3M2 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
TUBA1B TUBB2A â—¼   CORRELATES + 0.92 0.92 CCLE 31978347
TUBB2A TUBB3 â—¼   CORRELATES + 0.93 0.93 CCLE 31978347
OTUB1 UBC â—¼   PHYSICAL_INTERACTION 944.0 0.94 STRING 36370105
TUBA1B TUBB â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
TUBA1B TUBB3 â—¼   CORRELATES + 0.94 0.94 CCLE 31978347
ABCE1 RPS2 â—¼   PHYSICAL_INTERACTION 950.0 0.95 STRING 36370105
DCTN1 DCTN3 â—¼   PHYSICAL_INTERACTION 951.0 0.95 STRING 36370105
BRAF MAP2K2 â—¼   PHYSICAL_INTERACTION 958.0 0.95 STRING 36370105
ACTR1A DCTN1 â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
DCTN1 DCTN4 â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
AP3B1 AP3M1 â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
TUBA1B TUBB2A â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
HSP90AA1 PPP5C â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
ABCE1 ETF1 â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
AP3D1 AP3M1 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
AP3B1 AP3D1 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
ACTR1A DCTN4 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
HDAC6 UBC â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
UBC ZRANB1 â—¼   PHYSICAL_INTERACTION 979.0 0.97 STRING 36370105
TUBA1B TUBB3 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
DCTN1 PAFAH1B1 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
MAP2K2 MAPK1 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
UBA1 UBC â—¼   PHYSICAL_INTERACTION 989.0 0.98 STRING 36370105
ACTR10 ACTR1A â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
EEF2 RPS2 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
EEF2 RPL11 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
DCTN1 DYNC1H1 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
DYNC1H1 PAFAH1B1 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
MAPK14 MAPKAPK2 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
TSG101 UBC â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
ACTR10 DCTN4 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
ETF1 GSPT1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
PARK2 UBC â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
RPL11 RPS2 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
POLB FEN1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 21183466 19778542 20573551 11440997 15731342 6278323 15193131
DYNC1H1 ACTR10 â—¼   PHYSICAL_INTERACTION 28.0 1.0 Reactome 17274799 9490716 10679020 10562278 11306556 24891604 16723730 18086915 17283181 18664496 11035033 25453831 18046453 11285137 19564404 8642258 12198549 15728195 10903204 15878873 7691276 8909537 23839779 9150144 10559986 25233431 10036229 24806965
MAPKAPK2 AGO2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 27701455 28683311 27117408 28757069 22936947 34117353 18476811 23603119 20626350 30154469
MAPK1 BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 14654779 21478863 19541618 16508002 19710016 19933846 15664191 29335436 8621729
BRAF MAP2K2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 23331499 15342917 18039929 19541618 7706312 15466476 25600339 7731720 16135787 17563371 33226073 8668348 17667937 16255777
BTRC YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20048001 23431053 24976009 21900206
DCTN3 DYNC1H1 â—¼   PHYSICAL_INTERACTION 28.0 1.0 Reactome 17274799 9490716 10679020 10562278 11306556 24891604 16723730 18086915 17283181 18664496 11035033 25453831 18046453 11285137 19564404 8642258 12198549 15728195 10903204 15878873 7691276 8909537 23839779 9150144 10559986 25233431 10036229 24806965
PAFAH1B1 DYNC1H1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11889140 11163259 27173435 12885786 19622634 26496610 36692009
MAPK14 EEA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16138080
HDAC6 HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19158084 18591380 18266962
HSP90AA1 PPP5C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10400612 16531226 21360678 15577939 15383005
MAPK1 MAP2K2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11802164 15239952 21779496 11802165 15260967
MAPK14 MAP2K2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12738796 18039929 11274345 15187187
MAP2K2 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 68.0 1.0 Omnipath 21675959 11704645 9694850 17081983 7565670 12750173 19690332 12932319 11823456 18799465 15592455 11337027 18083107 21365009 12788955 11134045 19219045 17389395 9447970 15342917 23331499 19534553 17569879 7559390 23047924 8226933 8223433 17272394 15851026 15811950 19494114 18988627 18669648 11549292 23519423 19541618 18691976 1381507 16293107 17906627 11986622 19933846 8376945 19053285 16094384 11971971 17192257 11136732 11948414 8388392 7898932 9731057 11730323 18039929 11118451 19369195 12920017 15951569 15466214 10746662
MAPK14 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 15187187 21675959 18039929 12738796 11157753 22521293 17255949 11238443 11274345 12697810
MAPK1 MAPKAPK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 21675959 22028470 15094067 8846784 23047924 25255283 12861023 7592979 1327754 8995385
NCF2 MAPK14 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 16778989 25877926 14530365 27558335
TRAF6 MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10346818 17965022 15692051 17947236
MAPK14 MAPKAPK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 63.0 1.0 Omnipath 21675959 16456544 23602568 17395714 21988832 10581204 23331499 21071413 27898710 23047924 10922375 12738796 11551945 26496610 25852190 18988627 15629715 18669648 15187187 11042204 26186194 25241761 8846784 17906627 14499342 9922370 7923353 9768359 18039929 25255283 7592979 17255097 11274345 23455922
POLB POLB â—¼   KO_DOWN_REGULATES ✅ - -7.24 7.23 PKG 28854368