Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
TRAF2 DVL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
CAD TRAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
AASDHPPT TRAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
DCTN3 ACTR10 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15473859 15738427
RAF1 AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19197339 7014125
CASP3 AKT1 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 17544405 5219985
TBCD ARL3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6602175 18588884
CHUK AURKA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17939994 0706493104
CASP3 ITGB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17178732
CASP8 RAF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CASP8 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11002417
CBL FGFR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
EEF1A2 CHUK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TUBB CHUK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
MYH10 CHUK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
MYH9 CHUK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
CLASP2 MAPRE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19638411 19632184
SMAD4 DCP1B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
FXR2 DNM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
DTNBP1 PLCG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
FXR2 ECH1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
SMAD4 EEF1A1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
PFN2 EEF1A1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
EEF1A2 TRAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
MYH9 EIF2B1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
PLCG1 FGFR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16844695 10652257
LCMT1 FXR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
FXR2 MYH10 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
FXR2 TRAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
FXR2 MPP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
FXR2 MAGED1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
PITPNA SH3GLB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RIC8A TUBB2A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
ZEB1 SMAD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21421563
TUBB TBK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TRAF2 TBK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TUBB TRAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TUBB1 TUBB6 â—¼   CORRELATES + 0.8 0.8 CCLE 31978347
RABEP1 RABGEF1 â—¼   CORRELATES + 0.8 0.8 CCLE 31978347
EEF1A1P5 EEF1A2 â—¼   CORRELATES + 0.8 0.8 CCLE 31978347
BIRC6 CASP3 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 15200957 15507451
DYNC1LI1 HOOK3 â—¼   PHYSICAL_INTERACTION 818.0 0.81 STRING 36370105
LSR SMAD5 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
TUBB TUBB1 â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
BLOC1S5 DTNBP1 â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
WIPI2 ATG5 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 24954904 26186194 28514442 30340022
ACTR10 DCTN3 â—¼   PHYSICAL_INTERACTION 834.0 0.83 STRING 36370105
ARHGEF6 GIT2 â—¼   PHYSICAL_INTERACTION 834.0 0.83 STRING 36370105
AKT1 AURKA â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 24412244 28205554 28628118
AKT1 STK11 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 24412244 28205554 28628118
TUBB1 TUBB2A â—¼   CORRELATES + 0.84 0.84 CCLE 31978347
MTMR9 MTMR6 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 27880917
MTMR6 MTMR9 â—¼   PROXIMITY ✅ 0.85 0.85 mint 27880917
SMAD4 SMAD5 â—¼   PHYSICAL_INTERACTION 853.0 0.85 STRING 36370105
PFDN1 PFDN6 â—¼   CORRELATES + 0.85 0.85 CCLE 31978347
CBL ERBB2 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
CRTAP LEPRE1 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
ARL6IP4 PIP4K2B â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
TUBA1B TUBB1 â—¼   CORRELATES + 0.86 0.86 CCLE 31978347
CASP8 CASP3 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 11832478 11437602 8962078 18669646 15254227
CASP8 TRAF2 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
DSG2 DSC2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 11853539 21220045
FXR2 LCMT1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 16189514 16713569
HAUS2 HAUS5 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
SMAD5 SMAD4 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 10531362 16189514 15231748 16516194
AKT1 CHUK â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
TUBB TUBB2A â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
CLASP2 MAPRE1 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
SNX5 SNX2 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 21988832 26344197
AKT1 RAF1 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
ATG5 ATG3 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 20562859 24186333 28514442 33024031
BCL10 TRAF2 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 11466612 32296183 25910212 10753917 16713569 25416956
CHUK TRAF2 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
FNBP1 SNX2 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 14596906 11438682
MTMR6 MTMR9 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
CBL PLCG1 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
TUBB TUBB2A â—¼   CORRELATES + 0.88 0.88 CCLE 31978347
ATG3 MAP1LC3A â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
BLOC1S5 DTNBP1 â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
MAPRE1 MAPRE2 â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
MYH9 MYH10 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 16596254 22939629 26496610 24981860
EEF1A1 EEF1A2 â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
UBA6 UBE2Z â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
CBL MST1R â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
MAGEA6 RASSF10 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
TBK1 TRAF2 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
AKT1 GSK3A â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
GSK3A CAMKK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 22778263
SNX5 PFDN1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
BCL10 AKT1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 24412244 16280327 24462114
TBCD ARL2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 12912990 26344197 18588884 10831612
CHUK BCL10 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 19909372 16301747 16356855
TBK1 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10783893 21138416
SNUPN DBN1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
DNM2 HMGB1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
EEF2 DPH5 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15485916 3346227 1508200
EIF2B1 EIF2B3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17145710 17353931
PLCG1 ERBB2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 22973453 16273093 1683701 1676673
ZEB1 ITGB4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20729552
LAMB3 ITGB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12867433 8143784 32196115
KLF5 MYH10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10417400 11795310 10865841
TBCB TBCE â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
S100A13 S100A14 â—¼   PHYSICAL_INTERACTION 0.91 0.91 HuRI 32296183
TUBA1B TUBB â—¼   CORRELATES + 0.91 0.91 CCLE 31978347
CRTAP LEPRE1 â—¼   CORRELATES + 0.91 0.91 CCLE 31978347
TUBA1B TUBB2A â—¼   CORRELATES + 0.92 0.92 CCLE 31978347
TBCD TBCE â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
TUBA1B TUBB â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
ARL2 TBCD â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
SNX6 SNX2 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 33961781 32296183 26344197 11279102 22939629 21988832 22863883
TUBA1B TUBB2A â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
FGFR2 PLCG1 â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
SNX2 SNX6 â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
PLCG1 CBL â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 9234717 12941616 25241761 16467851 12061819 9712732 16713569 16503409 17372230 12803489
ATG3 ATG5 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
EFTUD1 SBDS â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
RABEP1 RABGEF1 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
PFDN1 PFDN6 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
AKT1 GSK3A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 110.0 1.0 Omnipath 15772344 19797085 23549785 20371716 11884598 25584893 11583116 11520785 14550568 19920184 15710331 21530327 9065430 16188907 24632852 12515807 11289110 24879152 20110348 12890758 15333638 14633703 11803463 16123357 8524413 21868755 12054501 23142783 25714023 16585200 15808505 22497526 16767165 19117997 14744935 19443725 21118801 18691976 18209096 11563975 17192257 11085518 19369195 19043530 11896604 10716737 19914182 19996208 21441927 32645325 15805282 21464307 34381779 16223362 12181443 15755769 11331582 11035810 21445305 27331409 16987514 11340086 15723049 22499768 18701488 11749387 20686112 11509608 19413330 20233866 15950778 20708687 14660586 17386267 11577096 15371448 11956225 12649200 16476742 11254732 21575859 14988390 11779850 19574224 20739666 17200115
GSK3A EIF2B5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 39.0 1.0 Omnipath 19651622 19007248 17081983 20166139 9468292 18691976 18088087 11500362 19664994 20068231 18452278 18707149 12133000 16097034 19413330 18669648 15302935
ACTR10 DYNC1LI1 â—¼   PHYSICAL_INTERACTION 28.0 1.0 Reactome 17274799 9490716 10679020 10562278 11306556 24891604 16723730 18086915 17283181 18664496 11035033 25453831 18046453 11285137 19564404 8642258 12198549 15728195 10903204 15878873 7691276 8909537 23839779 9150144 10559986 25233431 10036229 24806965
TBK1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21329883 21464307 21106850
CASP3 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 17544405 12124386 10579725
AKT1 RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 51.0 1.0 Omnipath 19197339 11971957 18767875 20230923 10576742 20068231 17570479 16189514 18669648 25241761 18691976 10576741 10618391 20688159 21745501 12087097 12801936 12048182 22798428 16854453 19058874 11997508
AKT1 MST1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 12919677 14505491
AKT1 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 15710601 12048203 25241761 19442713 11278366 10485711 15800029 19609947 17570479 17660512 18515365 19088076 10485710
DNM2 AP1M2 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10480952 7650016 7592972 10593899 14731593 2121367 9497313 8939989
DNM2 AP1M2 â—¼   GTPASE_REACTION ✅ 7.0 1.0 Reactome 10480952 7650016 7592972 10593899 2121367 9497313 8939989
ARL2 TBCD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12912990 18588884 10831612
ATG5 ATG3 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 22093031 22166994 23030059 23301705 23725295 24070470 24257061
MAP1LC3A ATG3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20562859 25503391 19838173 16303767 22170151
ATG5 CASP8 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 11003656 15325588 17462996 20531300 23725295 24070470 26587781 26972597 28574505 9488730
ATG5 CASP8 â—¼   SHARES_COMPLEX 10.0 1.0 ACSN 11003656 15325588 17462996 20531300 23725295 24070470 26587781 26972597 28574505 9488730
CASP3 BIRC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 15507451 15200957
CASP8 CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 15755874 17179148 9501089 9950028 18669646 23308069 10988287 18458084 16964285 9885230 9765224 11437602 15014070 21295084 8962078 9208847
CASP3 EIF4G3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 10611228 10672017
TRAF2 CASP8 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15024054 20696707 19278658 10837247 19416807 21235526
TRAF2 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17145710 12887920 20203691 16227629 21741934 17047155 22421964 30054040 11340079
CBL ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 25102001 20332299 17635922 10514377
CBL PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 7517397 9712732 12941616 25241761 12061819 23109003 9234717 16503409 11709089 16713569 17372230 16467851 12803489
TRAF2 CHUK â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 11274345 12847084 15592525 17462996 18641653 19392652 19509052 21133840 21232017 23430059 23850759 24378531 26587781
TRAF2 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 15725726 12547194 11359906 25241761 20449947 9244310 16713569 23007157 10795740 24323043 19150425
DCTN3 DYNC1LI1 â—¼   PHYSICAL_INTERACTION 28.0 1.0 Reactome 17274799 9490716 10679020 10562278 11306556 24891604 16723730 18086915 17283181 18664496 11035033 25453831 18046453 11285137 19564404 8642258 12198549 15728195 10903204 15878873 7691276 8909537 23839779 9150144 10559986 25233431 10036229 24806965
EEF1A1 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 11886851 16713569
ERBB2 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 16273093 1676673 1683701
FGFR2 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 12601080 17081983 7999363 16038803 1689310 1708307 7682059 15144186 8885868 16126727 15592455 8657103 16153436 24440983
ROCK2 MSN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 9856983 9456324 19144319 8522586 10970850 12778124 21242007 19255442 18493596 7579708 16601072 10047517 8527459 9287351 12045227 15634677 9516463 22479572 12802084
RABEP1 RABGEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17450153 26430212 24957337 12505986 9323142 17341663 11452015 10720461
SMAD4 ZEB1 â—¼   PHYSICAL_INTERACTION 36.0 1.0 ACSN 11074002 11279127 11792802 12490555 12702545 12743038 12809600 14623871 15265520 16510505 16617148 16713975 16831886 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18832382 19208835 19412634 19839049 20519943 20731704 21199805 21224848 21317430 21614932 21883379 22006115 22406545 225147423 22945800 9389648
SMAD4 ZEB1 â—¼   SHARES_COMPLEX 36.0 1.0 ACSN 11074002 11279127 11792802 12490555 12702545 12743038 12809600 14623871 15265520 16510505 16617148 16713975 16831886 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18832382 19208835 19412634 19839049 20519943 20731704 21199805 21224848 21317430 21614932 21883379 22006115 22406545 225147423 22945800 9389648
SMAD4 ZEB1 â—¼   UP_REGULATES ✅ + 36.0 1.0 ACSN 11074002 11279127 11792802 12490555 12702545 12743038 12809600 14623871 15265520 16510505 16617148 16713975 16831886 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18832382 19208835 19412634 19839049 20519943 20731704 21199805 21224848 21317430 21614932 21883379 22006115 22406545 225147423 22945800 9389648
SMAD5 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 20957627 23331499 14534577 16516194 16189514 10531362 15231748