Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
TAT GRN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SIRT3 HMGCS2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 21109197 22850421
SIRT3 ACSS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16790548 16788062
SIRT3 ALDH2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8203505 21720390
SIRT3 DNM1L â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
HIF1A ESRRA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0711677105 18509053
PPARG ESRRA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20519122 15821111
RIF1 ETHE1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
FLT3 IDH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 34289383
FOXO3 HIF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18268343 0706790105
FOXO3 SIRT3 â—¼   DEACETYLATION ✅ 2.0 0.8 Reactome 14976264 23665396
SIRT3 HIF1A â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 21109197 22850421
HIF1A MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12606552 15385570
TP53BP1 HSPD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NDUFA9 SIRT3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18794531 0803790105
PDHA1 PDP1 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 8226367 7782287
SIRT3 PEX5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
SIRT3 SOD2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 21109197 22850421
SIRT3 XRCC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18710944
MDM2 XRCC6 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 24147044 24583282 18784078 19247369
HSDL2 HERC2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
HIST1H3A SIRT5 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
ACAD9 PDK1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 29568061 28514442 32877691 33961781
FOXO3 MDM2 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
NDUFA10 UQCRH â—¼   PHYSICAL_INTERACTION 844.0 0.84 STRING 36370105
ACSS1 SIRT3 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
HSPA9 HSPD1 â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
ACAD9 PDK2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 32877691
HIF1A HSPA4 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
HIF1A MDM2 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
NDUFS7 UQCRH â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
PDHA1 PDK1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
PDK1 PDK2 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
ACSS2 SIRT3 â—¼   DEACETYLATION ✅ 3.0 0.9 Reactome 18680753 17923681 16788062
GLUD1 SIRT3 â—¼   DEACETYLATION ✅ 3.0 0.9 Reactome 18680753 17923681 16788062
HIF1A PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18461556 19490906 11879638
IDH2 SIRT3 â—¼   DEACETYLATION ✅ 3.0 0.9 Reactome 18680753 17923681 16788062
PDK2 PDK1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 12573248 26496610 26186194 29568061 28514442 32707033 16189514
PDK1 XRCC6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
PDK2 PDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16189514 12573248
SOD2 SIRT3 â—¼   DEACETYLATION ✅ 3.0 0.9 Reactome 18680753 17923681 16788062
ATP5A1 ATP5B â—¼   CORRELATES + 0.9 0.9 CCLE 31978347
NDUFA9 UQCRH â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
DLAT PDHA1 â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
NDUFS7 SDHB â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
NDUFA10 NDUFS7 â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
ACAD9 NDUFS7 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
NDUFA10 NDUFA9 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
NDUFA9 NDUFS7 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
ACAD9 NDUFS7 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 10465784 15526035 16200211 16218961 17344420 20025615 20816094 25371197 26989860
ACAD9 NDUFA9 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 10465784 15526035 16200211 16218961 17344420 20025615 20816094 25371197 26989860
ACAD9 NDUFA10 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 10465784 15526035 16200211 16218961 17344420 20025615 20816094 25371197 26989860
SIRT3 ACSS1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 16788062 16790548 21109197 22850421
ATP5A1 ATP5B â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 10838049 11410595 11744738 12110673 14701807 14757859 18953340 22841746
ATP5A1 ATP5B â—¼   SHARES_COMPLEX 8.0 1.0 ACSN 10838049 11410595 11744738 12110673 14701807 14757859 18953340 22841746
PDHA1 DLAT â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11752427 2188967 11935326 9242632
DLAT PDK1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
DLAT PDK2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
HIF1A FOXO3 â—¼   ENZYMATIC_REACTION ✅ 66.0 1.0 ACSN 10102273 10428030 10428780 10435632 10804084 10823814 11557773 11559532 11744734 11756417 11884613 12402042 12676992 12743597 14672622 14684737 14699081 14762718 15024076 15059920 15199147 15240700 15312748 15369676 15379897 15545625 16110315 16126909 16127144 16517405 16517406 16585195 16782875 16888645 17143338 17418790 17533374 17785433 18054315 18056423 18158893 18718909 19211554 20028863 20427344 20535745 20855962 21051947 21765015 22006996 22841746 22850421 22988108 24006507 25043024 25103413 25732824 7493931 7500013 7508926 8089148 8702901 8955077 9486205 9525945 9707622
MDM2 FOXO3 â—¼   ENZYMATIC_REACTION ✅ 14.0 1.0 ACSN 11715018 11779693 11923280 14761977 15024084 15084260 15169778 15876864 16307918 17110379 17158541 19321440 20679392 9450543
FOXO3 SOD2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 24068327 15674333 12239572 15308628 24339251
FOXO3 SOD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18280257 12239572 10492402 15766528
HERC2 RIF1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15468306 15574327 23333306 23306437 15723659 23727112
HERC2 XRCC6 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
HIF1A PDK1 â—¼   ENZYMATIC_REACTION ✅ 66.0 1.0 ACSN 10102273 10428030 10428780 10435632 10804084 10823814 11557773 11559532 11744734 11756417 11884613 12402042 12676992 12743597 14672622 14684737 14699081 14762718 15024076 15059920 15199147 15240700 15312748 15369676 15379897 15545625 16110315 16126909 16127144 16517405 16517406 16585195 16782875 16888645 17143338 17418790 17533374 17785433 18054315 18056423 18158893 18718909 19211554 20028863 20427344 20535745 20855962 21051947 21765015 22006996 22841746 22850421 22988108 24006507 25043024 25103413 25732824 7493931 7500013 7508926 8089148 8702901 8955077 9486205 9525945 9707622
HIF1A PDK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18269201 16517405 17855495
HIF1A HSP90B1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19828020 15620698
HIF1A HSPA4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15794924 14726529 20068160 18844219 18683594
MDM2 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 15880652 25535359 12606552 25447306 17234751 19696166 10640274
NDUFS7 NDUFA10 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094
NDUFA9 NDUFA10 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094
NDUFS7 NDUFA10 â—¼   SHARES_COMPLEX 10.0 1.0 ACSN 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094
NDUFA9 NDUFA10 â—¼   SHARES_COMPLEX 10.0 1.0 ACSN 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094
NDUFS7 NDUFA9 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094
NDUFS7 NDUFA9 â—¼   SHARES_COMPLEX 10.0 1.0 ACSN 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094
PDHA1 PDK2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDHA1 PDK1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDK1 PDHA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 45.0 1.0 Omnipath 17081983 20166139 18767875 17474719 7782287 19415658 15302935 11485553 20068231 19341700 22195962 82003483 18691976 18088087 16436377 7273851 12676647 20058876 11486000 18212344
PDP1 PDHA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 14644048 20208177 7782287 16545080 16436377
PDK2 PDHA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 40.0 1.0 Omnipath 12676647 19415658 17081983 82003483 20166139 18767875 17474719 18691976 22910903 11485553 11486000 7782287 19341700 16436377 7273851 18212344 15302935
TP53BP1 RIF1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15468306 15574327 23333306 23306437 15723659 23727112
XRCC6 RIF1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
TP53BP1 RIF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15342490 23333305 29203878
XRCC6 TP53BP1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
TP53BP1 TP53BP1 â—¼   KO_DOWN_REGULATES ✅ - -9.54 9.53 PKG 28854368