Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
CASP8 CASP3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18669646 0712034105
AKT3 CASP3 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 17544405 5219985
CASP3 AKT2 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 17544405 5219985
ATF4 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18729081 20101207
HDAC1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20049841 20821348
GMNN CDKN2A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15232106 5217098
CDKN2A CDK6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15232106 5217098
CHEK1 RB1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 17380128 5219804
KDM1A DNAJA3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23455924 8417751
DNAJB6 IK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RUNX1 EP300 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16917507 5218981
EP300 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23403292 24998469
EP300 CDKN2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22000024 19419955
EP300 H3C14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11509556
EP300 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16374512 11433299
EP300 H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20488183
SF3B2 KDM1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23455924 8417751
IK KDM1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23455924 8417751
KDM1A SMN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23455924 8417751
RCOR2 KDM1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21221247 19497860
KDM1A ACTB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16140033
H3C14 NOP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2BC21 NOP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
NOP2 RBM28 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H3C2 PRKDC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20080577 0913709107
PRKDC SYNE2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
RIF1 SMN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
RIF1 CDC42 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
XAB2 SNW1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
SNW1 SMAD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5213835 11278756
XAB2 SF3B2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
H2AX H2BC21 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2AX H4C6 â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 24981860
RUNX1 CDK6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17431401 5219852
CDK6 CCND3 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
SMAD4 IL10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14557415 21728174
SMAD4 IL10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20154735
GEMIN4 DDX20 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10725331 5212337
GMNN CDT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15232106 5217098
CDT1 GMNN â—¼   PROXIMITY 2.0 0.8 intact 17318181 5219681
ACTB POLR2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10773068 435297
CALM3 CAMKK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9822657 10187789
CALM3 CAMK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8340352 20668654
CALM2 CAMK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8340352 20668654
CALM2 CAMKK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9822657 10187789
H3C14 H4C7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
ZMYM2 SMAD4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD4 HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10199400 11427533
CREBBP SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9679056 9679060
NUP153 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12917407 23331499
SMAD4 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9679056 9679060
SMAD3 HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10199400 11427533
SMAD3 SMN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20123992 21965288
RB1 HDAC1 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
HDAC1 H4C6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10220385
CCNA2 CDT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17145710 14993212
CREBBP H3C14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11509556
CREBBP H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19056256
CDC42 EIF2AK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7738010 5220554
RUNX1 CCND3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16287839 14747476
RUNX1 CDKN2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 23487742 17283131
RUNX1 ELANE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15676205
DRD2 GNAO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1445393 31160049
PRPF6 IK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
SF3B2 CEBPZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H4C6 BRD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20709061 7989531
EGR3 BDNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22035109 16901909
UTP14A WDR33 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
ACIN1 PNN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2BC21 CLCN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2AC20 H3C14 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2BC21 H3C14 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2BC21 H4C6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2AC21 H1-10 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2AC21 H4C6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2BC13 H4C6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2BC13 H3C14 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2AC21 H3C14 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H3C14 H3-3B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
GTF2H2 POLR2B â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
CCND1 CDK1 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
SNW1 TFIP11 â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
ATF4 CREBBP â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
DDB1 HDAC1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 34026424 25189618 24249678 26679995
EP300 HDAC1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 14968110 30110629 22778253 16787918 33742100 18722353 22731250
EP300 CHD4 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 26546801 30110629 32699137 15189737
DNTTIP2 HEATR1 â—¼   PHYSICAL_INTERACTION 810.0 0.81 STRING 36370105
CCT3 CDC20 â—¼   PHYSICAL_INTERACTION 811.0 0.81 STRING 36370105
CALM3 GRIN1 â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
CALM2 GRIN1 â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
CDKN2A GMNN â—¼   PHYSICAL_INTERACTION 815.0 0.81 STRING 36370105
DKC1 RBM28 â—¼   PHYSICAL_INTERACTION 815.0 0.81 STRING 36370105
NOP56 UTP6 â—¼   PHYSICAL_INTERACTION 815.0 0.81 STRING 36370105
GTF2H2 POLR2A â—¼   PHYSICAL_INTERACTION 816.0 0.81 STRING 36370105
GCFC2 PRPF6 â—¼   PHYSICAL_INTERACTION 818.0 0.81 STRING 36370105
EP300 ATF2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 10327051 24069158
ACTB EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33742100 21988832
HDAC6 EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19344692 15102857 12718889 22778253 23133622
RBM34 NOP2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
RBM34 RBM28 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
SNW1 RBM22 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34133714 33961781
SMAD3 RUNX1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 10531362 15897867
HDAC1 ADNP â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23752268 26496610
CDK1 CDC25A â—¼   PHOSPHORYLATION ✅ + 0.82 0.82 Signor 12411508
CDC25A CDK1 â—¼   DEPHOSPHORYLATION ✅ + 0.82 0.82 Signor 10454565
PDCD11 UTP18 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
CDC20 CDK1 â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
DKC1 PPAN â—¼   PHYSICAL_INTERACTION 827.0 0.82 STRING 36370105
CCND1 CDK1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 26496610 33961781 7903056 21654808
CCND3 CDK1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194 26496610
CCNA2 EP300 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
CDC20 EP300 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 16319895
KDM1A ZMYM2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 18806873 33961781 34079125 12493763 16140033 16079794
KDM1A RCOR2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 34079125 24726434 28420882
PML SMAD3 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16189514 15356634
SNW1 CHD4 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 20467437 28977666 32744500
CLPB TTF2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 26186194 33961781 12927788
CCND1 EP300 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CCND3 CDK1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CDK1 CDC20 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28514442 10799291 26912231
CDT1 DDB1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 22451935 15448697
SNW1 UBR5 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
RUNX1 CDK6 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 17431401 25241761
AIFM1 CLPB â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 34079125 29568061
NUP153 NUP93 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
KDM1A ZMYM2 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
BCLAF1 THRAP3 â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
H4C7 MAIP1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HuRI 32296183
CEBPZ PES1 â—¼   PHYSICAL_INTERACTION 844.0 0.84 STRING 36370105
CCT6A CDC20 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
CDKN1B CDK1 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 34591612
DDB1 PHIP â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16949367 31911655 34171797 30018425 33503431 16964240 29089422 26344197
RUNX1 EP300 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 14752096 16917507
EP300 PRKDC â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 20808282 30110629 33742100
CCND1 CDKN2A â—¼   PHYSICAL_INTERACTION 850.0 0.85 STRING 36370105
CDK6 CDKN1B â—¼   PHOSPHORYLATION ✅ - 0.85 0.85 Signor 16160006
CCT4 CDC20 â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
HDAC1 RUNX1 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
DNTTIP2 UTP6 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
DNTTIP2 PDCD11 â—¼   PHYSICAL_INTERACTION 855.0 0.85 STRING 36370105
KDM1A RCOR2 â—¼   PHYSICAL_INTERACTION 857.0 0.85 STRING 36370105
NOP2 NOP56 â—¼   PHYSICAL_INTERACTION 858.0 0.85 STRING 36370105
DDX27 RBM34 â—¼   PHYSICAL_INTERACTION 858.0 0.85 STRING 36370105
AKAP8 CCND1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 14641107 21654808
SMAD4 EP300 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9679056 25514493 18215124 9843571 14612423 10887155 22033265
ATF4 EP300 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 14630807 17872950 10350644 12471036 16219772
EP300 SMAD3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9679056 15824515 15688032 16109717 15345715 20564330 9843571 15133024 10497242 17469184 15623506 10575014 15588252 18055455 16876108 21567395 11134049 12743039 11058129
H2AX PRKDC â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 20356835 22184063 26095369 15613478 18406329 14627815 20085707
CHEK1 DDB1 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
DDX27 PPAN â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
SRRM2 XAB2 â—¼   PHYSICAL_INTERACTION 864.0 0.86 STRING 36370105
SF3A1 SRRM2 â—¼   PHYSICAL_INTERACTION 864.0 0.86 STRING 36370105
CCT2 CDC20 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
CASP8 CASP3 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15254227 11832478 18669646 11437602 8962078
DKC1 EBNA1BP2 â—¼   PHYSICAL_INTERACTION 869.0 0.87 STRING 36370105
RBM28 RRP12 â—¼   PHYSICAL_INTERACTION 869.0 0.87 STRING 36370105
NOP56 RBM28 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 34079125 12777385 26496610
ZMYM2 HDAC1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 23752268 26496610 33961781 18806873
NOP56 UTP18 â—¼   PHYSICAL_INTERACTION 869.0 0.87 STRING 36370105
NUP85 NUP98 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24981860 24927568 26344197 24315095
IKZF1 CHD4 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 30760870 11003653 12015313 33961781
DDX20 GEMIN4 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
GNAI1 GNAI3 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CCNA2 CDT1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CHD4 IKZF1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
PRPF6 SRRM2 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
SF3A1 SNW1 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
GEMIN4 SMN1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
SF3B2 SRRM2 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
EP300 CCND1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15951563 10567390 11788592
CDT1 CDK1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 26186194 31160578 14993212
RBM14 EP300 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11443112 33742100 16713569
MLF2 AIFM1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 17353931 29568061
CEBPZ NOP2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 33961781 26344197
HDAC1 CHD4 â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 26949739
IKZF1 HDAC1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 23752268 16189514 30760870 10357820 12015313 10204490
RBM34 DKC1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 33961781
DKC1 NOP56 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 34079125 26344197
NOP56 RBM34 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 34079125 26344197
NOP56 DDX27 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 34079125 26344197
RBM34 CEBPZ â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 33961781
SMN1 DDX20 â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 11714716 5214807
EP300 SMAD4 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
GNAI1 GNG4 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
ACTB POLR2A â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
GNAI3 GNB4 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
CCNA2 RB1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
CREBBP SMAD3 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
CDK1 CDT1 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
MLF2 BAG2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17353931 33961781 25036637
CDKN1B CCND1 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 34591612
CDK1 CCNA2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 24302728 21308745 26496610 33422522 14681455 23602568 25852190 33961781 12853968 26186194 17679094 32707033 9053846 8463339 19483727
HDAC1 KDM1A â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 16079794 19703393 21258344 34050636 11102443 27183383 16140033 21937684 12032298 26496610 22143567 19497860 11171972 17634443 12493763 20856864 20585571 31130994 21670149 26344197 23752268 32882276 17687328 33961781 24981860 28667074
RBM28 NOP2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 33961781 26344197 30021884
SMAD3 SNW1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11278756 18729074
CDK6 CDKN2B â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
HDAC1 RCOR2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 23752268 33961781
CDC20 CCNA2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 27522463 19826003 23007648 19483727 18471975 26496610 25750436 25669885 19098431 26811472 10679238 25306918 32307883 20733051 31455778 26960431 33961781 32152539 26186194
CDT1 CCNA2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 18184650 26496610 31160578 33961781 26186194 14993212
H3C2 H4C6 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 7219095 19498464
CEBPZ PDCD11 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
CDK1 CDKN1B â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
DDB1 PHIP â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
CDK6 CDKN1B â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
NOP56 PDCD11 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
CDK1 RB1 â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
PDCD11 WDR36 â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
ATF2 CCNA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9511728 10777595 7843287
ATF2 RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18638549 15618023
BAK1 AIFM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12232790 23003569
YBX3 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16508013 20133805 19730435
SMAD3 CDC25A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21988832 15798217
CDK1 PML â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17477081 23526763 21840486
CREB3 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19340300
CHEK1 H3-3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18243098
EP300 HDAC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15102857 19344692
HDAC1 PML â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 16713569 11259576 18644863 25812002 11430826 23563092
STAG1 SMC1A â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31807710 29867216 26496610 17112726 10931856 26344197 11076961 17113138 31010829
STAG1 SMC3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17962804 17349791 29867216 26496610 15855230 17112726 10931856 22885700 26344197 11076961 17113138 31010829
H2AX ACTB â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
ATF4 EIF2AK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23009153 21146245 17141186
SMN1 ACTB â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
SMAD3 SMAD4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9111321 16189514 25514493 11927552 28443643 21988832 20211142 15084259 12732634 19768112 15467747 20142324 25609649 15922743 12917407 12419246 20564330 24382352 19139564 32296183 24157709 18729074 22442258 10092624 17283070 15350224 17591701 15761153 31591477 10995777 26555259 9892009 9311995 15588252 12167862 10878024 25910212 27703004 33990575 28115363 18055455 22310290 19135894 10531362 12794086 15231748 21297662 22045334 19917253 24584437 27107012 29892012 29997244 21532621 27845895 21597466 25502805 11114293 12543979 23788427
SMAD4 CDKN2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12429655 22710759 19419955
HDAC1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11306568 19049980 10575014
RUNX1 HDAC1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18316480 10617663 22777353
CHD4 HDAC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 25247294 32744500 21258344 11102443 28977666 9885572 26496610 20585571 10220385 22075476 21670149 22939629 23752268 27616479 9790534 9804427 26949739 20693977 33961781 24981860 12920132 26344197
RUNX1 CR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10597047 10533284 12220513
EP300 HDAC1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
DKC1 PES1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
NUP133 NUP98 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
CDK6 RB1 â—¼   PHYSICAL_INTERACTION 903.0 0.9 STRING 36370105
ACTB ACTG1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HuRI 32296183
RBM22 SF3B2 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
GTF2H4 POLR2B â—¼   PHYSICAL_INTERACTION 907.0 0.9 STRING 36370105
CCND3 CDKN1B â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
GNAI1 GNB4 â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
PDCD11 UTP6 â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
SF3B2 SNW1 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
CCND1 CDK6 â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
RBM22 SRRM2 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
PES1 WDR74 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
NOP56 UTP14A â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
HDAC1 RB1 â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
IK PRPF6 â—¼   PHYSICAL_INTERACTION 925.0 0.92 STRING 36370105
SF3B2 XAB2 â—¼   PHYSICAL_INTERACTION 926.0 0.92 STRING 36370105
HEATR1 NOP56 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
GTF2H4 POLR2A â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
NOP2 PES1 â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
HEATR1 PDCD11 â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
CCNA2 CDK1 â—¼   PHYSICAL_INTERACTION 929.0 0.93 STRING 36370105
STAG1 SMC3 â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 17962804 6178082
NOP56 CEBPZ â—¼   PROTEIN_INTERACTION 0.93 0.93 HIPPIE 34079125 26496610
NOP56 RRP12 â—¼   PROTEIN_INTERACTION 0.93 0.93 HIPPIE 34079125 26496610
HEATR1 UTP6 â—¼   PHYSICAL_INTERACTION 929.0 0.93 STRING 36370105
DNTTIP2 WDR36 â—¼   PHYSICAL_INTERACTION 929.0 0.93 STRING 36370105
GTF2H1 POLR2A â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
GNB3 GNG11 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
GNB3 GNGT2 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
GNB4 GNGT2 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
DDX27 RRP12 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
EBNA1BP2 PES1 â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
HEATR1 UTP18 â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
HEATR1 WDR36 â—¼   PHYSICAL_INTERACTION 936.0 0.93 STRING 36370105
CCNE2 CDKN1B â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
DDX3X PRPF6 â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
UTP18 WDR36 â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
UTP18 UTP6 â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
GNAI1 GNAI3 â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 28514442 22939629 33961781 26186194
DDX27 RBM34 â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 28514442 33961781 26344197
SNW1 SRRM2 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
CHD4 HDAC1 â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
EBNA1BP2 NOP2 â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
EP300 SMAD3 â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
CCND1 RB1 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
RBM22 SNW1 â—¼   PHYSICAL_INTERACTION 948.0 0.94 STRING 36370105
ACTG1 ACTB â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 8153045 21516116
RB1 HDAC1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 6550000 10779361
NOP56 WDR36 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 34079125 26344197 26496610
SF3A1 XAB2 â—¼   PHYSICAL_INTERACTION 950.0 0.95 STRING 36370105
UTP6 WDR36 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
CCND3 CDK6 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
CDKN1B CCNA2 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 34591612
NOP2 NOP56 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 34079125 22939629 26344197 26496610
NUP133 NUP85 â—¼   PHYSICAL_INTERACTION 959.0 0.96 STRING 36370105
SMN1 GEMIN2 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 11714716 5214807
SF3A1 SF3B2 â—¼   PHYSICAL_INTERACTION 964.0 0.96 STRING 36370105
DDX20 GEMIN2 â—¼   PHYSICAL_INTERACTION 964.0 0.96 STRING 36370105
DDX20 SMN1 â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
CDC25A CHEK1 â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
CDK6 CCND1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15232106 16713569 10022865 24855949 17517622 33854235 11739795 14681455 24953629 11360184 33961781 10580009 17420273 21654808 11160398 9178893 19075005
SMC3 SMC1A â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 17112726 21111234 31807710 17349791 26496610 10931856 17113138 18832153 11590136 12759374 30021884 22885700 22939629 9789013 31010829 21880767 11877376 23242214 24981860 27173435 11076961 26344197
CDK6 CCND3 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 8153045 21516116
CDK6 CCND3 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 16189514 25416956 33854235 14681455 21516116 32296183 17517622 9716181 11360184 30217970 23602568 15232106 26264872 27107012 32707033 16782892 16713569 8114739 29997244 32814053 33961781 26186194
GMNN CDT1 â—¼   PROXIMITY ✅ 0.97 0.97 mint 17318181 5219681
HDAC1 KDM1A â—¼   PHYSICAL_INTERACTION 970.0 0.97 STRING 36370105
RBM22 XAB2 â—¼   PHYSICAL_INTERACTION 970.0 0.97 STRING 36370105
DKC1 NOP56 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
NUP85 NUP98 â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
NOP56 WDR36 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
CCNA2 CDC20 â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
CDK6 CDKN2A â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
CCND1 CDKN1B â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
CCNA2 CDKN1B â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
PRPF6 SF3B2 â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
SMC1A STAG1 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
CCT2 CCT6A â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CCT3 CCT6A â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CCT4 CCT6A â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB3 GNG10 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB3 GNG4 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB3 GNG5 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB3 GNG3 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB3 GNG7 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB4 GNG7 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB4 GNG4 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB4 GNG3 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB4 GNG5 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GEMIN2 SMN1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
SMC3 STAG1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
SNW1 XAB2 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
PRPF6 SF3A1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CDT1 GMNN â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CCT2 CCT3 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT3 CCT4 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT2 CCT4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GTF2H1 GTF2H4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2A POLR2B â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ATF2 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9990041 10915780 11850817 11410592 11739785 15691880 16405968 10464245 10500157 15314161 10066798
RB1 ATF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 1641004 11566021
SMAD4 ATF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10085140
CDK1 BAD â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 12049737 14551205 15279786 17303408 17660363 18414028 18590585 21725609 7575488
CDK1 BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 18071308 16166315 24677263 12965220 15907327 26287183 21858202 25618528 12049737 16009721 19124971 16403219 17498878
AKT3 BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 26.0 1.0 Omnipath 9346240 11493700 20398329 21506126 9381178 20028971 12040186 21303971 15280015 20214616 10230394 10558990 8929531 10837486 11882383 10611223 23109003 12954615 22094462 10949026 15023346 17680028 18218901 17270021
AKT2 BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 27.0 1.0 Omnipath 9346240 11493700 20398329 21506126 9381178 15452053 20028971 12040186 21303971 15280015 20214616 10230394 10558990 8929531 10837486 11882383 10611223 12954615 22094462 10949026 11438654 17680028 10516287 18218901 17270021
BAZ1B H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 22971774 27449264 26941327 20823147 20965415 19092802 19707781 21326359 25979708 31151422 30013081 19234442 26628370 27220480
CASP8 CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 15755874 17179148 9501089 9950028 18669646 23308069 10988287 18458084 16964285 9885230 9765224 11437602 15014070 21295084 8962078 9208847
CASP3 ACIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10490026 21904669
CASP3 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 10822366 11420704 9092486
CASP3 PRKDC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 8798786 12867423 8670824 8804412
RB1 CCND1 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 Reactome 10207050 9447971 24876129 31543423 11416152 11032757 9190208 30711375 10499802
EP300 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 17306568 17666529 11788592 23343194 21285352 15576399 21151179 22761862 22290435 16039586 19619488 19623618 17143292
CDKN1B CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 17145710 9106657 10908655 17254966 25416956 7478582
CDC25A CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 7575488 18590585 17303408 18073536 1075565 17568790 18786381 17660363 15279786
CCND1 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 27.0 1.0 Omnipath 10498883 9315635 17303408 16236519 11520855 15279786 9190208 7575488 10385618 9736735 8490963 26225123 19237565 7736585 19075565 18590585 27507850 26121043 20068082 9425340 18786381 17660363 10778858 9380698 27430527
CCND1 CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 19075005 17517622 9178893 11739795 24855949 15232106 16713569 11360184 10580009 11160398
CDK1 CDC25A â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 1075565 12124778 14551205 14614141 15242590 15279786 15375219 15377654 15485915 15917306 16713580 16818604 17303408 17568790 17596790 17660363 18073536 18414028 18543256 18590585 18786381 18995830 19652693 19686080 7575488 9892021
CHEK1 CDC25A â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 15459660 15798197 17102137 17116885 17296725 17384638 17568790 17582221 18677104 19793801 20126263
CHEK1 CDC25A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 75.0 1.0 Omnipath 12676583 22040655 29435105 12759351 14681206 18677104 20860841 15798197 19793801 22655267 12963847 16682204 14752276 16647857 15736430 29725502 17116885 17582221 20126263 16697662 18167338 19075565 9278511 18480045 17384638 21148633 21252624 27493659 12110582 17030123 23335075 20068082 11298456 27908669 27213455 25936524 15459660 28150240 20798862 22263797 27038604 17296725 14559997 12399544 17102137 17568790 16488126
CDK1 CDC25A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 17303408 18073536 1075565 19413330 15279786 7575488 17172867 17570479 12411508 18167338 27580187 18927152 19652693 18590585 12124778 18786381 17660363 21379580 15917306 22263797 27038604 17568790
CDC25A CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 7575488 18590585 17303408 18073536 1075565 17568790 23429262 18786381 17660363 15279786
CDK1 CDT1 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 14551205 15279786 17102137 17116885 17296725 17303408 17582221 17660363 18414028 18590585 19793801 7575488
CDK1 CDC20 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 12124778 14551205 14614141 15242590 15279786 15375219 15377654 15485915 15917306 16713580 16818604 17303408 17596790 17660363 18414028 18543256 18590585 18995830 19652693 19686080 7575488 9892021
CDK1 RB1 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 14551205 15279786 17218262 17303408 17660363 18414028 18590585 7575488
CCNA2 CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17145710 1833185 10924145 8423786
EIF2AK2 CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 25149538 20395957
CDK1 RUNX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 25914884 19386523 21059642 17015473 18003885 16046550
CDK1 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20937773
CDK1 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 23455152 23543736 25032860 21490307 16492801 10931950
CDK1 NUP98 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 21335236 25247763
CDK1 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 36.0 1.0 Omnipath 17303408 19690332 15084261 19413330 19664995 15279786 7575488 21249227 92097548 20068231 18669648 18590585 1756735 17660363 19651622 20058876 18220336 10542199 19664994
CDK1 CHEK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 20798862 19837665 18691976 21765472 21907702 29092815 18983824 16629900 22686412 24242917
CDK1 DDX3X â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 16280325 17379183
RB1 CDKN1B â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 Reactome 10207050 9447971 24876129 31543423 11416152 11032757 9190208 30711375 10499802
AKT2 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12244303 18593906
CDK6 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 16160006 25241761 18615582 16782892 21439954 11360184
CCNE2 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17254966 9840927 9858585 9840943
CDKN1B CCNA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 17145710 8684460 26186194 9660939 17254966 15890360 16209941 12947099 12501191 26496610 9724724 9311993 9716181
CDKN1B CCNE2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17254966 9840927 9858585 9840943
CDKN1B CCND3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 14597415 16189514 10342870 16328436
EP300 CDKN2A â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 32284348 19273602 32601262 10821856 28985506 33043019 31597407
CDKN2A CREBBP â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 32284348 19273602 32601262 10821856 28985506 33043019 31597407
RUNX1 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12732181 18276842 21757616 10851069 12091906 23673926
CDKN2A CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 17881001 26186194 23602568 9751050 11739795 11556834 9380698 15232106 16713569 17955473 10491434 16915296 17909018
CDKN2A HUWE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17145710 16915296 15989956
CHEK1 CDT1 â—¼   PHYSICAL_INTERACTION 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
CHEK1 CDT1 â—¼   DOWN_REGULATES ✅ - 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
CHEK1 CDT1 â—¼   REGULATES ✅ 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
CHEK1 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17380128
CHEK1 H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 18451105 20068082 23844048 12560483 18066052 20948546 21357687 18243098
AKT2 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17964260 16926151
EP300 H4C6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19423655 11689053 16332960
EP300 H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 21875947 19270680 19158375 20587414
EP300 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 9843571 19419955 22033265 9679056 21269274
EP300 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 9843571 11134049 12743039 15133024 15824515 15623506 16876108 21567395 16109717 17074756 20564330 10497242 15588252 17469184 15345715 11058129 10575014 16862174
GTF2H1 GTF2H2 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
GTF2H1 GTF2H2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 21988832 10734072 11062469 9130708 8652557 8194529
GTF2H2 GTF2H4 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
KDM1A H3-3B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17277772 24371278 19098913 18187655
KDM1A H3C2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17277772 24371278 19098913 18187655
KDM1A H4C6 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17277772 24371278 19098913 18187655
KDM1A H3C14 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17277772 24371278 19098913 18187655
KDM1A H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16223729 20210320 18343668 20228790 15620353
AIFM1 NDUFA10 â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 15526035 16200211 16218961 16489074 17344420 20025615 20816094 24684389
AIFM1 NDUFA10 â—¼   SHARES_COMPLEX 8.0 1.0 ACSN 15526035 16200211 16218961 16489074 17344420 20025615 20816094 24684389
AIFM1 NDUFA10 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 15526035 16200211 16218961 16489074 17344420 20025615 20816094 24684389
PML SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 21071413 15356634 16189514 18988627
PRKDC H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 107.0 1.0 Omnipath 18454178 9488723 19321613 21930799 19305155 25487737 22819196 20493860 17570479 12607005 16673875 26976643 17723002 21151168 16039583 21514376 26438602 19049966 20368801 23916969 16935931 27919340 17923115 16061642 18438399 20157519 20461094 21690091 24253929 19531483 26960975 25168287 18758438 19268590 27813335 25690891 17210576 26748709 18406329 23972723 17412408 34429760 27551505 12692309 29221122 20703100 16861886 25070753 27332952 33691101 33863809 23653357 21283714 16788066 19781914 20205745 20860841 21389100 16148027 20116089 15610743 20192759 20224553 14627815 24893124 10734083 20488183 23185622 18157161 33945602 30573684 12766154 25699710 18755145 27738310 10477747 34504648 16820894 20356835 19014481 20713529 17525342 23671119 26114388 23355489 28790110 23678292 20118229 23166506 33986864 15604242 16377563 20609246 12907603 26119999 25072018 15289343 23891091 25269479 23620287 33731502 22972376 34282773 26578593
H4C6 RIF1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15468306 15574327 23333306 23306437 15723659 23727112
H2AX RIF1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15468306 15574327 23333306 23306437 15723659 23727112
SMC1A SMC3 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
CDC20 SMC3 â—¼   UP_REGULATES ✅ 8.0 1.0 ACSN 12070128 15279786 17303408 17660363 18590585 21270334 23197039 7575488
ATF4 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11564156 9295363 25241761
RB1 CDK6 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 Reactome 10207050 9447971 24876129 31543423 11416152 11032757 9190208 30711375 10499802
CDKN2B CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 26186194 26578655 23602568 25416956 32296183
CCND3 CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 17517622 8114739 26186194 27107012 23602568 10477583 16782892 21516116 25416956 29997244 31515488 32814053 15232106 32296183 11360184 16713569 9716181
CDK6 RUNX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 18261462 20478528 25241761 17023045 16046550 17431401 17015473 21059642 15475366 22531928
CDK6 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 43.0 1.0 Omnipath 10498883 9315635 17303408 11416152 15081408 16236519 19690332 16936279 11520855 16107892 19413330 15279786 16360038 9190208 14627988 7575488 24417566 8822197 10385618 9736735 9139732 7736585 19075565 29372101 18590585 27507850 22682621 20068082 9425340 25549286 18786381 17660363 15809340 27811360 10778858 9380698
IL10 MARCH1 â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 10433356 10542212 10623821 10925299 11207245 11438547 11875494 12193690 12811837 12818165 14607900 15282297 15579430 15749903 15833879 16200688 16424049 16713974 17404308 17485448 20184663 20435894 20547845 21115385 21191065 21220452 23124025 23508573 24378531 26755705 9834059
GMNN CDT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 36.0 1.0 Omnipath 17145710 20980834 17318181 17261582 22581055 14993212 14578910 21543332 15232106 26496610 18617514 11125146 15257290 15855168 19906994 27107012 15138268 16482215 18162579 18184650
ACTB CDC42 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 24914801 15507212 16439214 22608513
CCR5 GNAI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520 15251452
DRD2 GNAI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 2898118 1445393 10978845 10384262 31160049
GNAI3 ADCY5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 23109003 15539636 7935349 16460834 11376933 8327893
CDC42 ACTG1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 24914801 15507212 16439214 22608513
SMAD3 SMAD4 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
SMAD4 SMAD3 â—¼   PHYSICAL_INTERACTION 72.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013125 11013220 11074002 11114293 11224571 11279127 11283613 11283614 11376132 11399519 11792802 11875494 12193690 12545156 12702545 12809600 14976548 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 16831886 17018611 17055429 17260466 17550342 17563753 17689680 17705132 18353785 18768831 18832382 19208835 19597490 19815509 19901969 20027199 20713526 20731704 21041997 21042762 21098712 21252118 21317430 21577210 21614932 2191300 22331441 22514743 22652804 23140366 23338822 23390297 23784029 23869868 25374926 6357187 8515656 8871614 8893010 9312026 9389648 9618481 9670020
SMAD4 SMAD3 â—¼   PROTEIN_INTERACTION 72.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013125 11013220 11074002 11114293 11224571 11279127 11283613 11283614 11376132 11399519 11792802 11875494 12193690 12545156 12702545 12809600 14976548 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 16831886 17018611 17055429 17260466 17550342 17563753 17689680 17705132 18353785 18768831 18832382 19208835 19597490 19815509 19901969 20027199 20713526 20731704 21041997 21042762 21098712 21252118 21317430 21577210 21614932 2191300 22331441 22514743 22652804 23140366 23338822 23390297 23784029 23869868 25374926 6357187 8515656 8871614 8893010 9312026 9389648 9618481 9670020
SMAD4 SMAD3 â—¼   LOCALISATION ✅ 72.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013125 11013220 11074002 11114293 11224571 11279127 11283613 11283614 11376132 11399519 11792802 11875494 12193690 12545156 12702545 12809600 14976548 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 16831886 17018611 17055429 17260466 17550342 17563753 17689680 17705132 18353785 18768831 18832382 19208835 19597490 19815509 19901969 20027199 20713526 20731704 21041997 21042762 21098712 21252118 21317430 21577210 21614932 2191300 22331441 22514743 22652804 23140366 23338822 23390297 23784029 23869868 25374926 6357187 8515656 8871614 8893010 9312026 9389648 9618481 9670020
SMAD3 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 104.0 1.0 Omnipath 25609649 9843571 15084259 20211142 21532621 24584437 18729074 23788427 12419246 18923419 9892009 19768112 10531362 15231748 9679060 12167862 21988832 12150994 23331499 12543979 18568018 21071413 19135894 15467747 25502805 9732876 11927552 16189514 12917407 25514493 15350224 10995777 18988627 10092624 12732634 25910212 10878024 9111321 20564330 27107012 9311995 12957874 20142324 11114293 32296183 15588252 15761153 24157709 26555259 29892012 17469184 22442258 16714330 21597466 15922743 22045334 17591701 24382352 22310290 19139564 19917253 29997244 31515488 28115363 10942775 21297662 17283070 12794086
SMAD4 CDKN2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9389648 11013220 10454538 9670020 11283613 11074002 11283614
SMAD3 CDKN2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14647420 15326485 23032366 16819512
CREBBP SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 15849193 10497242 15467747 18003620 9679056 15990875 15750622 19589780 17074756 17283070 9679060
NUP153 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 12917407
SMAD3 CDKN2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9389648 11013220 10454538 9670020 11283613 11074002 11283614
CDC20 CCNA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 15577895 10679238 18471975 15840442 25669885
CAMK4 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11970865
CCR5 GNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520 15251452
GNAI1 ADCY5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 9748257 23109003 15539636 7935349 16460834 11376933
AKT3 CREB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 19216069 17680028 11756412 16680151 20214616 11463845 20452955 9829964 20398329 17646672 10217147
RB1 CCND3 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 Reactome 10207050 9447971 24876129 31543423 11416152 11032757 9190208 30711375 10499802
CCND3 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 10498883 9315635 17303408 16236519 11520855 15279786 9190208 7575488 10385618 9736735 16782892 7736585 19075565 18590585 20068082 9425340 8449399 18786381 17660363 8343202 17972097 10778858
H4C6 BRD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 14731392 20709061 12776177 17148447 19766566
CCNE2 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 7575488 18590585 10207050 9315635 17303408 19638577 17660363 12006580 11420722 15279786
CAMKK2 CAMK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 9822657 11395482 21957496 8621423 8702940 7642608 15262966 19506079 8631893 8636117 7615569 15143065