Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
CYCS APAF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 9267021 5221616
CDC5L YWHAG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
GRB2 UACA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 PPP1CB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 PPP1R12A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 KRT8 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 MYH9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 MED14 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
FGFR1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9480847 16713569
YWHAG VIM â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
VIM UACA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
VIM MAP3K3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
VIM KRT8 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
MYH9 MAP3K3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HIF1A HIF1AN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24421387 19726677
NFKB1 CFTR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11114294
NFKB1 HIF1AN â—¼   HYDROXYLATION ✅ 2.0 0.8 intact 17003112 0606877103
ESR1 BMI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24559156 16582100
UACA HIF1AN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17003112 0606877103
PPP1R12A HIF1AN â—¼   HYDROXYLATION ✅ 2.0 0.8 intact 17003112 0606877103
YWHAG MAP3K3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
ESR1 YWHAQ â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22329840
ESR1 EPHB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17685427 20484412
ESR1 KRT8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14605097
BTF3 EPHB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17312387
YWHAH MAP3K3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
PPP1R12A MAP3K3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
YWHAZ MAP3K3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
YWHAQ MAP3K3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
UACA MAP3K3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
UACA REL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
REL NFKBIE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
UACA NFKBIE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
ANKRD28 NFKBIE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
KRT8 UACA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
YWHAZ PPP1R12A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8008120 18094049
CFTR YWHAG â—¼   PHYSICAL_INTERACTION 810.0 0.81 STRING 36370105
CFTR YWHAZ â—¼   PHYSICAL_INTERACTION 812.0 0.81 STRING 36370105
CDC5L 1433T â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31413325 17043677
CDC5L ANLN â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 20467437 31586073
GRB2 1433G â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31980649 21706016
GRB2 1433B â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31980649 21706016
GRB2 1433Z â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31980649 21706016
PNMA5 UACA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
RHOB JPH1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
ANLN MYH9 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31586073 26496610
1433Z MYH9 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 20618440 20936779
CFTR VTNC â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 26618866 31324722
RHOB ANLN â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
ANLN UACA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33961781 26496610
RGS3 REL â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
1433B UACA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
1433G UACA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
1433Z UACA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
VTNC UACA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
1433T VTNC â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
RGS3 UACA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
1433F UACA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
1433T UACA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
SYNCI UACA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
MS18A UACA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
RHOB UACA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
JPH4 UACA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
GCYB1 UACA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
CORO6 UACA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
UACA UBP48 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33903120 22939629
1433Z CDC5L â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 90000000 31413325 17043677
CDC5L DISC1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 90000000 31413325 17043677
HDAC6 CFTR â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 31501480 22069321 14675537
ESR1 1433Z â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 33731348 19805454 25604459
1433T DISC1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 90000000 31413325 17043677
1433Z DISC1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 90000000 31413325 17043677
TIGD7 UACA â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
KRAS NRAS â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
ESR1 MYH9 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 21182205 19805454 25604459
CFTR MYH9 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 22038833 29924966 26618866
CFTR 1433Z â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 26618866 31324722 29924966
APAF1 CYCS â—¼   PHYSICAL_INTERACTION 853.0 0.85 STRING 36370105
1433G CDC5L â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 17353931 15324660
CYCS CASP9 â—¼   PHYSICAL_INTERACTION ✅ + 0.86 0.86 Signor 9390557
BCAR1 GRB2 â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
CQ059 DISC1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 32296183 33961781 26186194
RGS3 1433B â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 10862767 11985497
PICK1 UACA â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 31413325 33961781 26186194
PP1B UACA â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28330616 26496610
CQ059 UACA â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 33961781 34079125 26186194
GRB2 STAMBP â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
HRAS NRAS â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
GRB2 MYH9 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 12577067 20936779 24189400
CD2AP BCAR1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10339567 12618476
RAC3 ESR1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16331275 21217774
ESR1 BTF3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 31527615 18025262
YWHAG YWHAZ â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
YWHAG YWHAH â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
YWHAH YWHAZ â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
NFKBIE REL â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
UBQLN2 VTN â—¼   PHYSICAL_INTERACTION 0.88 0.88 HuRI 32296183
1433T ESR1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11266503 33731348 31527615
TNIK DISC1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 32707033 29961565 90000000 31413325 17043677
1433G 1433F â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 17979178 26496610 22863883 33961781 15324660 26344197
1433G 1433T â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 17085597 20618440 22863883 33961781 15324660
1433F 1433Z â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 17979178 26496610 20618440 22863883 33961781 26344197
RGS3 1433Z â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 20347994 11985497 16160139
1433Z 1433T â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 26496610 20618440 22863883 33961781
1433F 1433T â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 17979178 26496610 20618440 22863883 33961781
HRAS KRAS â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
KRT31 MAB21L2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
BCAR1 GRB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10085298 16105984 8649368 8700507 10822386
NFKB1 HIF1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18498249 17898080
NFKB1 REL â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 14743216 27609421 17962807 35140242 33961781 25609649 26186194 15143182
ESR1 MED14 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19805454 11867769 10770935 31527615
REL EPHB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19621336
1433Z 1433G â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 28628118 31536960 26496610 20618440 22863883 33961781 28205554 26344197
EPHB2 PICK1 â—¼   PROTEIN_INTERACTION 0.91 0.91 HIPPIE 10839360 9883737 33961781
NFKB1 REL â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
HIF1AN HIF1A â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 6802010 19071119
PPP1CB PPP1R12A â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
CASP9 APAF1 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 5221774 9390557
CD2AP GRB2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 10339567 19380743 21706016 21988832
1433F 1433B â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 17979178 26496610 33961781 24255178 26344197
1433G 1433B â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 17085597 33961781 24981860 24255178 15324660 26344197
1433T 1433B â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 17085597 20618440 22863883 33961781 24255178
1433Z 1433B â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 31536960 26496610 20618440 33961781 24255178 26344197
APAF1 CASP9 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
HIF1A HIF1AN â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CYCS APAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 11753565 10393175 10364241 15829969 16977332 15907471 10722681 9390557 10578178 16713569 9267021 12147322 10206961 10329646 11112785 10940292
APAF1 CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 63.0 1.0 Omnipath 17145710 15829969 15024710 9390557 19494828 11113115 10617566 9539746 10364241 10722681 27476169 21060833 19118655 20829884 16977332 10329646 15210107 10393175 16352606 11242052 14555243 10376594 12773388 10206961 19337385 10428850 9488720 19788417 15262985 9922454 21827945 10749135 9651578 19698783 12792650 9837928 11227497
CASP9 CYCS â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9390557 25313070 20462491 27697150
CYCS CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 19788417 16977332 9390557 16713569 12147322 12773388 10329646 12792650 15210107
CASP9 VIM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19118655 11423904 10469173 11514563
FGFR1 GRB2 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 17505008 18757403 21666749 11689702 11739186 18381441 19809159 21160078 14534538 15448205
FGFR4 GRB2 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 17505008 18757403 21666749 11689702 11739186 18381441 19809159 21160078 14534538 15448205
HRAS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
KRAS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
NRAS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
GRB2 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17496910 16713569 17673906 11352655
PPP1CB RHOB â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 9354661 8662509 11331307 11942626
MYH9 PPP1CB â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 9354661 8662509 11331307 11942626
MYH9 RHOB â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 12185584 2966156 8702756 17151359 3839510
PPP1R12A MYH9 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 9354661 8662509 11331307 11942626
HRAS FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
HRAS FGFR4 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
FGFR1 BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11019781 12601080
NFKB1 HIF1A â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 17272744 18393939 21725609 23178297 23572150
HIF1AN HIF1A â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 11641274 12042299 12080085 12215170 22841746
HIF1A HIF1AN â—¼   OXIDOREDUCTASE_ACTIVITY_ELECTRON_TRANSFER ✅ 6.0 1.0 Reactome 12615973 11823643 14701857 12042299 12080085 15239670
HIF1AN HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 31.0 1.0 Omnipath 12573436 11641274 14734545 12042299 12215170 12446723 17244529 19071119 17003112 12080085 19696166 16189514 19940151 24145445 26751287 12432100 26972000 17382325 19074848 26752685
KRAS FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
NRAS FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
FGFR1 SYNCRIP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 12601080
NFKBIE NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 9315679 17145710 12835716 14743216
YWHAG YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17085597 21827211 12426317 15324660 15071501 12657644
YWHAH YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21827211 12657644 12426317 15071501
KRAS FGFR4 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
NRAS FGFR4 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
PPP1R12A RHOB â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 9354661 8662509 11331307 11942626
YWHAZ YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21827211 12657644 12426317 15071501