Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
DCUN1D3 CUL1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19617556 0812528106
NEDD8 CUL1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 intact 0806155105 18723677
CUL1 UBE2M â—¼   NEDDYLATION ✅ 2.0 0.8 intact 17914462 6175264
DCUN1D3 CUL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19617556 0812528106
ELOC CUL2 â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 5219492 17183367
UBE2M CUL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17439941
ELOC COMMD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17183367 5219492
HTT AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NFKB1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18031796
BCR CFTR â—¼   COLOCALIZATION 2.0 0.8 intact 5217253 15494376
HIF1A BIRC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19828020 17043658
NFKB1 BIRC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9294162 9733516
RELA CFTR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11114294
NFKB1 CFTR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11114294
COMMD1 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17183367 5219492
UBC COPS5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7229502 19214193
COPS5 TCEB1 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
DCUN1D3 CUL3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19617556 0812528106
CUL3 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
EP300 SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20339243 21467818
EP300 RELA â—¼   ACETYLATION ✅ 2.0 0.8 intact 5214468 11533489
FAM167A HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HIF1A SOCS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20003295
HIF1A SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17848618 19016748
HTT UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
KAT2A SOCS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19339690
NEDD8 XIAP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8373364 22584050
NFKBIA NFKB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
UBC NFKB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18617892 6804701
SKP1 NFKB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17145710 14743216
REL NFKBIA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
NFKBIA UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219675 17318178
RELA REL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5211837 10498867
RBX1 UBC â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
CUL4A DCUN1D1 â—¼   PHYSICAL_INTERACTION 807.0 0.8 STRING 36370105
CUL4B DCUN1D1 â—¼   PHYSICAL_INTERACTION 807.0 0.8 STRING 36370105
CUL1 DCUN1D3 â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
NFKB1 EP300 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 22013068 12960163 14662860 12471036 23811396 11739381 20065107
C16ORF62 COMMD4 â—¼   PHYSICAL_INTERACTION 811.0 0.81 STRING 36370105
CUL1 DDB1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22474075 21145461
CUL4A NFKB1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30945288 21145461
CUL4A SKP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22474075 21145461
RBX1 ELOC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33504946 12149480
CTBP1 EP300 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 15834423 21102443 16122695 35016035
CUL3 CUL5 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22709582 21145461
NFKB2 UBC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 18617892 14743216
COMMD1 COMMD8 â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
DCUN1D1 NEDD8 â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
COMMD4 COMMD9 â—¼   PHYSICAL_INTERACTION 827.0 0.82 STRING 36370105
CCDC22 COMMD5 â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
CCDC93 COMMD8 â—¼   PHYSICAL_INTERACTION 829.0 0.82 STRING 36370105
UBC XIAP â—¼   PHYSICAL_INTERACTION 829.0 0.82 STRING 36370105
NEDD8 ELOC â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 21145461 16503656 18247557
CFTR BCR â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 17110338 15494376
CFTR HSPA4 â—¼   PHYSICAL_INTERACTION 832.0 0.83 STRING 36370105
COMMD1 CUL2 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
COMMD1 NFKBIA â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CCDC93 COMMD4 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
COMMD4 TFDP1 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
COMMD10 COMMD5 â—¼   CORRELATES + 0.83 0.83 CCLE 31978347
CCDC22 COMMD10 â—¼   CORRELATES + 0.83 0.83 CCLE 31978347
CUL1 CUL3 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
COMMD6 E2F6 â—¼   PHYSICAL_INTERACTION 845.0 0.84 STRING 36370105
CAND1 CUL5 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
AKT1 ARNT â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 28205554 28628118 15833858
CAND1 SKP1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 12504026 29499133 21145461
UBE2F NEDD8 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 24654937 23201271
CUL3 CUL1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 26344197 21145461
ELOC CUL3 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 21988832 21145461
NEDD8 CUL4B â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 24654937 10597293 18274552 21145461 16503656 23201271 31973889 16620772
CCDC22 CCDC93 â—¼   CORRELATES + 0.86 0.86 CCLE 31978347
CUL3 UBE2M â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
NEDD8 TCEB1 â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
CUL4A CUL1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 17079684 32235678 21145461
HIF1A CUL2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 23401859 27320910 18323857 17439941 17132228 19940151
CCDC22 COMMD3 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
COMMD1 RELA â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
COMMD1 COMMD6 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
COMMD1 COMMD4 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
COMMD10 COMMD3 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
COMMD3 COMMD6 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
COMMD3 COMMD9 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
COMMD4 COMMD5 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
COMMD6 COMMD9 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
DCUN1D3 UBE2M â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
SKP1 UBC â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CCDC93 COMMD2 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
COMMD1 COMMD2 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
COMMD1 COMMD5 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
COMMD2 COMMD4 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
RELA RELB â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
COMMD1 COMMD10 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
COMMD10 COMMD2 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
CUL3 DCUN1D3 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
HIF1A HSPA4 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
CUL2 DCUN1D3 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
COMMD1 COMMD3 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
COMMD3 COMMD8 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
COMMD4 COMMD6 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
COMMD4 COMMD8 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
HSPA4 PARK2 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
CAND1 DCUN1D1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
COMMD2 COMMD3 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
EP300 NFKB1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
CCDC93 COMMD3 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
COMMD2 COMMD5 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
COMMD5 COMMD8 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
REL RELB â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
COMMD1 COMMD7 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
CCDC93 COMMD10 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
C16ORF62 COMMD3 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
C16ORF62 CCDC22 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
CCDC22 COMMD9 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
CCDC93 COMMD6 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
COMMD3 COMMD4 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
COMMD4 COMMD7 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
COMMD7 COMMD8 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
NFKBIA SKP1 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
CFTR ELOC â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 26618866 29924966 17110338 31324722
CFTR LMNA â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 26618866 29924966 17110338 31324722
DDB1 KAT2A â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11564863 21987584
CUL7 SKP1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
CCDC22 COMMD10 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
COMMD10 COMMD8 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
CUL7 RBX1 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
COPS5 DDB1 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
COMMD10 COMMD7 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
AKT1 EP300 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
CUL1 NFKBIA â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
CCDC22 COMMD4 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
CCDC22 COMMD5 â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
CCDC22 COMMD7 â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
COPS5 CUL4B â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
REL RELA â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
NEDD8 RBX1 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
NFKB2 RELA â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
HIF1A UBC â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
NFKB2 NFKBIA â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
CUL4A NEDD8 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
CUL2 DCUN1D1 â—¼   PHYSICAL_INTERACTION 899.0 0.89 STRING 36370105
CUL3 DCUN1D1 â—¼   PHYSICAL_INTERACTION 899.0 0.89 STRING 36370105
CAND1 CUL1 â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 12504025 12504026 15537541
CUL4A CAND1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 12504026 16964240 21145461 12504025 27203177 21249194 18606781 17079684 22405651 15448697 19295130 31973889 22474075 12609982
HIF1A ELOC â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 17965024 12050673 17558023 18323857 12004076 19940151 17244529 17353276 21658608
CUL5 ELOC â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 30166453 22479405 23098073 20463065 31253590 24390320 23806657 24076655 14564014 24402281 24438103 17351129 15574593 28514442 24390335 16530799 11384984 32513959 21145461 21199876
EP300 ARNT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12573436 10999956
CUL3 CAND1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 21145461 21249194 22013077 16449638 22405651 26286618 12609982
CAND1 RBX1 â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 12504025 12504026 15537541
CAND1 SKP1 â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 12504025 12504026 15537541
CLU COMMD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20068069 22130675
COMMD8 COMMD3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
COPS5 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11707426 18926707
RBX1 CUL4B â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 28446751 34026424 29499938 22038470 19250909 26496610 31973889 12481031 30349055 24292684 30945288 33969670 27113764 32140073 33504946 12609982 25189618 23238014
NEDD8 CUL5 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 18805092 24654937 33961781 18274552 10597293 21119685 21145461 23201271 24076655 18247557 28522566 22405651 31253590 28514442 20847044
SOCS1 CUL5 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18481982 9869640 19649319
RBX1 CUL7 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 17332328 24793695 24793696
EP300 KAT2A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 23667505 23555303 21559432
NFKB1 HIF1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18498249 17898080
RELB NFKB2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 22864569 12505990 27609421 22388891 14743216 14678988 28514442 17962807
RBX1 NFKBIA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10230406 9859996 10066435
SOCS1 RBX1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18481982 9869640 19649319
CUL5 DCUN1D1 â—¼   PHYSICAL_INTERACTION 902.0 0.9 STRING 36370105
CCDC22 CCDC93 â—¼   PHYSICAL_INTERACTION 904.0 0.9 STRING 36370105
NEDD8 SKP1 â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
NFKB1 REL â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
NFKB2 REL â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
CCDC22 COMMD2 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
COPS5 CUL4A â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
CAND1 CUL3 â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
CAND1 CUL4A â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
COPS5 CUL3 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
SOCS1 TCEB1 â—¼   PHYSICAL_INTERACTION 919.0 0.91 STRING 36370105
UBE2M NEDD8 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 19713960 7294536
EP300 RELA â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
COMMD10 COMMD5 â—¼   PHYSICAL_INTERACTION 0.92 0.92 HuRI 32296183
CUL1 UBC â—¼   PHYSICAL_INTERACTION 925.0 0.92 STRING 36370105
NEDD8 UBC â—¼   PHYSICAL_INTERACTION 925.0 0.92 STRING 36370105
RBX1 UBE2M â—¼   PHYSICAL_INTERACTION 0.92 0.92 HuRI 32296183
COPS5 NEDD8 â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
E2F6 TFDP1 â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
COPS5 RBX1 â—¼   PHYSICAL_INTERACTION 935.0 0.93 STRING 36370105
CAND1 CUL2 â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
CUL3 NEDD8 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
DCUN1D3 UBE2F â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
SKP1 CUL1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 7304783 18818696
TFDP1 E2F6 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 24981860
SCNN1B SCNN1G â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
CUL1 CAND1 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 17290223 5219620
NEDD8 CUL2 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 23401859 24654937 18274552 10597293 10318914 21145461 31444342 18826954 16503656 23201271 18247557 19617556 18173839 17132228 10585493 16620772
SOCS1 ELOC â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 16643902 21119685 31980649 29991678 17183367 10051596 22787435
CAND1 CUL4B â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
COPS5 CUL2 â—¼   PHYSICAL_INTERACTION 964.0 0.96 STRING 36370105
COPS5 CUL1 â—¼   PHYSICAL_INTERACTION 968.0 0.96 STRING 36370105
NEDD8 CUL1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 21765416 16177058 18723677 18627766 17438373 32726803 24654937 11027288 18274552 10772955 16503656 24076655 18247557 22405651 17318178 10713156 19713960 10318914 21102408 23267066 23201271 22959436 17206147 16620772 18805092 10597293 21119685 21145461 18826954 19245792 19617556 12565873 18264111 24949976 22474075
CUL2 ELOC â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 11384984 9122164 10449727 31444342 30166453 21145461 23563313 26735018 24981860 19327355 24076655 29991678 15601820 19339690 17183367 9447969 25661653 15966899
HIF1A ARNT â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 33961781 12391259 10085255 16954218 7836384 17916562 26496610 8663540 34592152 14764593 20603618 14668441 21512126 11606485 26350169 9079689 24056783 19845609 27684187 11782478 19168635 23363003 26160453 28628118 15850782 17197389 21620138 15833858 23086815 24434214 20458141 18024476 23458834 12810720 28514442 15347669 9704006 27320910 20562859 11829741 15031145 21435239 20049704 15479785 20932347 12393189 11025203 16861921 9159130 10671489 16520375 15615775 17213817 28205554 23796364 15319539 11593383 19251694 20699359
HIF1A EP300 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 18268343 15154850 12914934 19074848 25192544 22789427 20829524 21148070 17502379 26826385 22075993 16543236 19680224 20603618 19589782 11063749 23618863 26135796 27808477 22219185 15155277 11823643 17906695 19666581 21187066 16189267 8917528 23746844 19940151 19071119 26944191 15261140 24421387 20000859 12778114 14691445 12042299 22684029 12588875 17382325 23966271 15342390 22735262 27320910 26751287 24821806 23448368 11959990 15280364 11940656 19696166 20620956 16081065 22908229 18047470 16847340 22807441 23880760
NFKB1 NFKB2 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 35140242 15660126 15169888 27609421 14743216 25609649 21988832 17962807
NFKBIA REL â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
HIF1A TCEB1 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
CAND1 RBX1 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
CUL2 NEDD8 â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
DCUN1D1 RBX1 â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
NEDD8 UBE2M â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
NFKB2 RELB â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
CUL5 NEDD8 â—¼   PHYSICAL_INTERACTION 979.0 0.97 STRING 36370105
DDB1 RBX1 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
CUL4B RBX1 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
CUL5 RBX1 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
CUL1 UBE2M â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
DCUN1D1 UBE2M â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
NFKB1 RELB â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
CUL4A RBX1 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
NFKB1 NFKBIA â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
CUL5 TCEB1 â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
CUL3 RBX1 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
CUL2 RBX1 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
PARK2 UBC â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CUL1 DCUN1D1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CUL4B DDB1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CAND1 CUL1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
EP300 HIF1A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
NFKBIA RELA â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CUL1 RBX1 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
CUL4A DDB1 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
ARNT HIF1A â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
NFKB1 RELA â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
RBX1 CUL1 â—¼   PHYSICAL_INTERACTION 76.0 1.0 ACSN 10023660 10671552 11348595 11900249 11955436 11967263 12051714 12648680 12820959 14536078 15001769 15071497 15147722 15340381 15459660 15489953 15688063 1570337 15703371 16039586 16469695 16697054 16713974 16940750 17053147 17143292 17652783 17884153 17928543 17936032 18196958 18636226 18787170 18805092 18931676 19143635 19150432 19250909 19258535 19270156 19352404 19366350 19411070 19557001 19576224 19597341 19619488 19622404 19686080 19751508 19797085 19809470 19836308 19847258 19849719 20006983 20211143 20558317 20705860 20832730 20843316 20976471 21411632 22270359 22682247 22730322 23343194 23732914 24023259 25730849 26159692 26885856 7542250 7641885 8666229 9694792
UBE2M CUL1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 16647857 19617556 18826954 25349211 25314029 18206966 21940857 23201271 26906416 19250909 25531226 21863050
REL CUL1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 10321728 9990852 10066435 9859996 10514424 10230406
NFKB2 CUL1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9346238 15340381 16303288 8706131
RELA CUL1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9990852 10514433 9859996 9990853 7628694
NFKB1 CUL1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9990852 10514433 9859996 9990853 7628694
RELB CUL1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9346238 15340381 16303288 8706131
CUL1 SKP1 â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 11516665 11900249 12648680 12820959 14536078 15071497 15147722 15340381 15459660 15489953 15668399 15688063 15703371 16697054 17053147 17884153 18636226 18787170 18931676 19150432 19270156 19622404 19686080 19797085 19809470 19847258
CUL1 NEDD8 â—¼   PHYSICAL_INTERACTION 61.0 1.0 ACSN 10023660 10671552 11348595 11900249 11955436 11967263 12051714 12648680 12820959 15001769 15071497 15340381 15459660 15688063 15703371 16039586 16697054 16713974 16940750 17143292 17652783 17884153 17928543 17936032 18196958 18805092 18931676 19250909 19258535 19270156 19352404 19366350 19411070 19576224 19597341 19619488 19622404 19686080 19751508 19809470 19836308 19847258 19849719 20006983 20558317 20705860 20843316 20976471 21411632 22270359 22682247 22730322 23343194 23732914 24023259 25730849 26885856 7542250 7641885 8666229 9694792
RBX1 CUL1 â—¼   SHARES_COMPLEX 76.0 1.0 ACSN 10023660 10671552 11348595 11900249 11955436 11967263 12051714 12648680 12820959 14536078 15001769 15071497 15147722 15340381 15459660 15489953 15688063 1570337 15703371 16039586 16469695 16697054 16713974 16940750 17053147 17143292 17652783 17884153 17928543 17936032 18196958 18636226 18787170 18805092 18931676 19143635 19150432 19250909 19258535 19270156 19352404 19366350 19411070 19557001 19576224 19597341 19619488 19622404 19686080 19751508 19797085 19809470 19836308 19847258 19849719 20006983 20211143 20558317 20705860 20832730 20843316 20976471 21411632 22270359 22682247 22730322 23343194 23732914 24023259 25730849 26159692 26885856 7542250 7641885 8666229 9694792
CUL1 NEDD8 â—¼   SHARES_COMPLEX 61.0 1.0 ACSN 10023660 10671552 11348595 11900249 11955436 11967263 12051714 12648680 12820959 15001769 15071497 15340381 15459660 15688063 15703371 16039586 16697054 16713974 16940750 17143292 17652783 17884153 17928543 17936032 18196958 18805092 18931676 19250909 19258535 19270156 19352404 19366350 19411070 19576224 19597341 19619488 19622404 19686080 19751508 19809470 19836308 19847258 19849719 20006983 20558317 20705860 20843316 20976471 21411632 22270359 22682247 22730322 23343194 23732914 24023259 25730849 26885856 7542250 7641885 8666229 9694792
CUL1 SKP1 â—¼   SHARES_COMPLEX 26.0 1.0 ACSN 11516665 11900249 12648680 12820959 14536078 15071497 15147722 15340381 15459660 15489953 15668399 15688063 15703371 16697054 17053147 17884153 18636226 18787170 18931676 19150432 19270156 19622404 19686080 19797085 19809470 19847258
RBX1 CUL1 â—¼   ENZYMATIC_REACTION ✅ 76.0 1.0 ACSN 10023660 10671552 11348595 11900249 11955436 11967263 12051714 12648680 12820959 14536078 15001769 15071497 15147722 15340381 15459660 15489953 15688063 1570337 15703371 16039586 16469695 16697054 16713974 16940750 17053147 17143292 17652783 17884153 17928543 17936032 18196958 18636226 18787170 18805092 18931676 19143635 19150432 19250909 19258535 19270156 19352404 19366350 19411070 19557001 19576224 19597341 19619488 19622404 19686080 19751508 19797085 19809470 19836308 19847258 19849719 20006983 20211143 20558317 20705860 20832730 20843316 20976471 21411632 22270359 22682247 22730322 23343194 23732914 24023259 25730849 26159692 26885856 7542250 7641885 8666229 9694792
AKT1 CUL1 â—¼   ENZYMATIC_REACTION ✅ 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
CUL1 NEDD8 â—¼   ENZYMATIC_REACTION ✅ 61.0 1.0 ACSN 10023660 10671552 11348595 11900249 11955436 11967263 12051714 12648680 12820959 15001769 15071497 15340381 15459660 15688063 15703371 16039586 16697054 16713974 16940750 17143292 17652783 17884153 17928543 17936032 18196958 18805092 18931676 19250909 19258535 19270156 19352404 19366350 19411070 19576224 19597341 19619488 19622404 19686080 19751508 19809470 19836308 19847258 19849719 20006983 20558317 20705860 20843316 20976471 21411632 22270359 22682247 22730322 23343194 23732914 24023259 25730849 26885856 7542250 7641885 8666229 9694792
CUL1 NFKBIA â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10066435 11900249 12648680 12820959 15071497 15340381 15459660 15688063 15703371 16697054 17884153 18931676 19150432 19270156 19622404 19686080 19809470 19847258 9859996
CUL1 SGK1 â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 11154281 11500365 11900249 12648680 12820959 15071497 15340381 15459660 15688063 15703371 16469695 16697054 17884153 18570873 18636226 18925875 18931676 19143635 19584721 19622404 19686080 19809470 19847258 20338997 20832730 26159692
AKT1 CUL1 â—¼   DOWN_REGULATES ✅ - 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
RBX1 CUL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 154.0 1.0 Omnipath 17053147 12684064 20638939 11967263 19797085 19258535 26540345 18826954 15071497 15448697 21765416 25730849 10230406 23343194 21169563 22270359 19250909 23732914 11359933 12051714 20006983 15361859 10748083 19352404 22682247 18787170 12504025 18636226 16469695 15459660 20211143 10535940 15001769 26725323 19411070 11861641 26159692 16697054 1570337 19751508 22822056 11348595 7542250 7641885 19849719 16759355 12820959 17452440 19622404 15703371 10648623 19245792 23331499 9694792 19150432 23180781 19597341 16189514 22474075 18988627 22767593 17143292 24949976 10713156 23770852 22405651 19942853 18196958 20399188 16713974 26192618 11027288 17884153 19933270 22730322 21411632 11961546 17936032 19809470 15147722 19270156 19576224 11483504 20976471 12504026 24023259 12840033 15340381 12904573 20558317 11900249 14536078 19686080 12565873 18805092 15489953 19557001 26885856 17652783 12481031 20843316 11955436 21071413 16039586 11956208 20705860 8666229 17928543 10023660 19836308 16940750 12706828 19143635 15688063 10671552 16123592 19366350 19847258 12417738 11245432 20832730 12648680 12609982 19619488 10230407 18931676
SKP1 CUL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 66.0 1.0 Omnipath 9663463 19945379 12684064 19270694 16759355 23951410 10648623 11961546 26540345 26976582 26474281 17290223 9736735 21169563 14685242 16357137 21145461 29070679 15452136 15966899 12628165 21778237 22474075 16189514 22767593 11359933 9430629 10713156 10023660 10228155 12504026 18818696 9827542 12504025 18094045 10066435 23324393 23770852 9990852 12417738 27705803 9636170 21249194 12904573 34499862 11027288 26725323 20832730 19933270 12609982 10230407
CAND1 CUL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 45.0 1.0 Omnipath 17145710 12684064 25435324 36076154 23019411 18826954 17290223 17438373 21169563 27542266 16036220 21145461 21778237 22474075 22767593 16861300 18173839 12504026 12504025 12706828 22405651 21249194 23453757 22013077 17439941 12609982 15537541
UBE2M CUL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 24949976 10713156 17914462 21247897 18805092 21946088 19245792 18826954
CUL1 NFKBIA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 17145710 10713156 9990852 17914462 14743216 10066435 9859996
RBX1 CUL2 â—¼   PHYSICAL_INTERACTION 21.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18420585 18931676 18985005 19622404 19622774 19686080 19809470 19847258
CUL2 TCEB1 â—¼   PHYSICAL_INTERACTION 21.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18420585 18931676 18985005 19622404 19622774 19686080 19809470 19847258
RBX1 CUL2 â—¼   SHARES_COMPLEX 21.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18420585 18931676 18985005 19622404 19622774 19686080 19809470 19847258
CUL2 TCEB1 â—¼   SHARES_COMPLEX 21.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18420585 18931676 18985005 19622404 19622774 19686080 19809470 19847258
CUL2 HIF1A â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
NEDD8 CUL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16620772 15688063 11696557 21145461
UBE2M CUL4A â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 19617556 18826954 25349211 26460955 25314029 18206966 23201271 26906416 19250909 25531226 26344709
CCDC22 CUL4A â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 17183367 21778237 23563313 25355947 17497243 15799966
RBX1 CUL4A â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
DDB1 CUL4A â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
CUL4A COMMD1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 17183367 21778237 23563313 25355947 17497243 15799966
RBX1 CUL4A â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
DDB1 CUL4A â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
CUL4A COPS5 â—¼   DEMETHYLATION ✅ 9.0 1.0 Reactome 19748355 18926707 16401342 18093314 23535663 23583660 22959436 16943200 23535662
CAND1 CUL4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 17145710 18606781 19295130 22405651 27203177 17079684 21249194 19231300 12504026 21145461 12504025 22474075 12609982 16964240 15448697
NEDD8 CUL4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 9694792 18805092 21145461 19250909 19231300
ELOC HIF1A â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 11292861 9122164 10878807 12821933 12101228 11292862 10823831 11504942 11454738 10944113 11358837 11024059
AKT1 RBX1 â—¼   ENZYMATIC_REACTION ✅ 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
AKT1 RBX1 â—¼   DOWN_REGULATES ✅ - 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
HIF1A AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19144925 17220299 17488804 14726529 15277220
RELA AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20186924 18031796 20649564
AKT1 XIAP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23640046 25241761 17698078 14645242
AKT1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 17623675 18182168 16926151 20333651 19158375 17964260 17570479 11116148 25904863 21901101 23275565 16024795
ARNT HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 17213817 8816435 17197389 14764593 12393189 12810720 15319539 23363003 9079689 11829741 15479785 26496610 12391259 17916562 24434214 11606485 20562859 9704006 21620138 11782478 20932347 15347669 8927054 21435239 19168635 9159130 14668441 20049704 20603618
NFKB1 BIRC3 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 21725609 23178297 23572150 9294162 9733516
NFKB1 BIRC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 15231833 15050749 19343319 17673602 17000776 11880364 10733571 9733516 18566231 12010810 15723831 10823821 11297551
RELA BIRC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 15231833 15050749 19343319 17673602 18226221 23250755 17000776 11880364 21279667 21765477 10733571 18566231 12010810 15723831 10823821 11297551 16291753
REL BIRC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12414938 23271966 11880364
SKP1 CAND1 â—¼   PHYSICAL_INTERACTION 15.0 1.0 Reactome 19748355 12504025 18805092 15688063 18851830 23453757 15537541 23535663 11961546 26632597 21463634 12504026 12609982 23535662 21863050
DDB1 CAND1 â—¼   PHYSICAL_INTERACTION 14.0 1.0 Reactome 19748355 12504025 18805092 15688063 18851830 23453757 15537541 23535663 11961546 21463634 12504026 12609982 23535662 21863050
RBX1 CAND1 â—¼   PHYSICAL_INTERACTION 15.0 1.0 Reactome 19748355 12504025 18805092 15688063 18851830 23453757 15537541 23535663 11961546 26632597 21463634 12504026 12609982 23535662 21863050
CCDC22 CAND1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 17183367 21778237 23563313 25355947 17497243 15799966
CAND1 COMMD1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 17183367 21778237 23563313 25355947 17497243 15799966
CCDC22 CUL4B â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 17183367 21778237 23563313 25355947 17497243 15799966
CCDC22 DDB1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 17183367 21778237 23563313 25355947 17497243 15799966
CCDC22 NEDD8 â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 19617556 18826954 25349211 25314029 18206966 21940857 23201271 26906416 19250909 25531226 27030794
CCDC22 UBE2F â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 19617556 18826954 25349211 25314029 18206966 21940857 23201271 26906416 19250909 25531226 27030794
CCDC22 COPS5 â—¼   DEMETHYLATION ✅ 9.0 1.0 Reactome 19748355 18926707 16401342 18093314 23535663 23583660 22959436 16943200 23535662
EP300 CDKN2A â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 32284348 19273602 32601262 10821856 28985506 33043019 31597407
DDB1 COMMD1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 17183367 21778237 23563313 25355947 17497243 15799966
UBE2M COMMD1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 16647857 19617556 18826954 25349211 25314029 18206966 21940857 23201271 26906416 19250909 25531226 21863050
CUL4B COMMD1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 17183367 21778237 23563313 25355947 17497243 15799966
NEDD8 COMMD1 â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 19617556 18826954 25349211 25314029 18206966 21940857 23201271 26906416 19250909 25531226 27030794
COMMD1 UBE2F â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 19617556 18826954 25349211 25314029 18206966 21940857 23201271 26906416 19250909 25531226 27030794
COMMD1 COPS5 â—¼   DEMETHYLATION ✅ 9.0 1.0 Reactome 19748355 18926707 16401342 18093314 23535663 23583660 22959436 16943200 23535662
XIAP COMMD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18795889 14685242 14685266
DDB1 COPS5 â—¼   DEMETHYLATION ✅ 9.0 1.0 Reactome 19748355 18926707 16401342 18093314 23535663 23583660 22959436 16943200 23535662
RBX1 COPS5 â—¼   DEMETHYLATION ✅ 9.0 1.0 Reactome 19748355 18926707 16401342 18093314 23535663 23583660 22959436 16943200 23535662
CUL4B COPS5 â—¼   DEMETHYLATION ✅ 9.0 1.0 Reactome 19748355 18926707 16401342 18093314 23535663 23583660 22959436 16943200 23535662
RBX1 CUL3 â—¼   PHYSICAL_INTERACTION 34.0 1.0 ACSN 11583996 11900249 12648680 12820959 14744430 15340381 15459660 15688063 15703371 15760909 16498403 16547521 16697054 17312394 17884153 18545270 18931676 19090789 19427028 19560419 19622404 19686080 19809470 19818716 19847258 20006983 20531300 20599425 23030059 23377657 23845861 23850759 27984721 9242610
UBE2M CUL3 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 19617556 18826954 25349211 23912815 25314029 18206966 21940857 23201271 26906416 19250909 30610225 25531226
RBX1 CUL3 â—¼   SHARES_COMPLEX 34.0 1.0 ACSN 11583996 11900249 12648680 12820959 14744430 15340381 15459660 15688063 15703371 15760909 16498403 16547521 16697054 17312394 17884153 18545270 18931676 19090789 19427028 19560419 19622404 19686080 19809470 19818716 19847258 20006983 20531300 20599425 23030059 23377657 23845861 23850759 27984721 9242610
UBE2M CUL4B â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 19617556 18826954 25349211 26460955 25314029 18206966 23201271 26906416 19250909 25531226 26344709
NEDD8 DCUN1D1 â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 19617556 18826954 25349211 25314029 18206966 21940857 23201271 26906416 19250909 25531226 27030794
UBE2F DCUN1D1 â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 19617556 18826954 25349211 25314029 18206966 21940857 23201271 26906416 19250909 25531226 27030794
RBX1 DDB1 â—¼   PHYSICAL_INTERACTION 27.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19270156 19440234 19557001 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
UBE2M DDB1 â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 19617556 18826954 25349211 26460955 25314029 18206966 23201271 26906416 19250909 25531226 26344709
RBX1 DDB1 â—¼   SHARES_COMPLEX 27.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19270156 19440234 19557001 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
EP300 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 19608861 25400040 11567019 12419806 17617622 11533489 20333651 12456660 15152190 16846590 9096323 20064247 16382138 16713569 15171256 16135789
EP300 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 75.0 1.0 Omnipath 24821806 12573436 17145710 16847340 12588875 19589782 11940656 25192544 11959990 18519678 23448368 22219185 11823643 12042299 15342390 23746844 19071119 19680224 27808477 15154850 19696166 8917528 17906695 18268343 22735262 21148070 15261140 19940151 23880760 22807441 35430356 14691445 12914934 20000859 12778114 26751287 16081065 22789427 16543236 24421387 17382325 17502379 22684029 21187066 19074848 23618863 23966271 20603618
RBX1 HIF1A â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 11292861 9122164 10878807 12821933 12101228 11292862 10823831 11504942 11454738 10944113 11358837 11024059
TCEB1 HIF1A â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
NFKB1 HIF1A â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 17272744 18393939 21725609 23178297 23572150
RBX1 HIF1A â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
RELA HIF1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18498249 17898080 23185316
HIF1A HSPA4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15794924 14726529 20068160 18844219 18683594
SGK1 HTT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 12062094 15843398 14725621
RBX1 NEDD8 â—¼   PHYSICAL_INTERACTION 61.0 1.0 ACSN 10023660 10671552 11348595 11900249 11955436 11967263 12051714 12648680 12820959 15001769 15071497 15340381 15459660 15688063 15703371 16039586 16697054 16713974 16940750 17143292 17652783 17884153 17928543 17936032 18196958 18805092 18931676 19250909 19258535 19270156 19352404 19366350 19411070 19576224 19597341 19619488 19622404 19686080 19751508 19809470 19836308 19847258 19849719 20006983 20558317 20705860 20843316 20976471 21411632 22270359 22682247 22730322 23343194 23732914 24023259 25730849 26885856 7542250 7641885 8666229 9694792
NEDD8 UBE2F â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 25314029 15361859 19250909 17220875 25531226
RBX1 NEDD8 â—¼   SHARES_COMPLEX 61.0 1.0 ACSN 10023660 10671552 11348595 11900249 11955436 11967263 12051714 12648680 12820959 15001769 15071497 15340381 15459660 15688063 15703371 16039586 16697054 16713974 16940750 17143292 17652783 17884153 17928543 17936032 18196958 18805092 18931676 19250909 19258535 19270156 19352404 19366350 19411070 19576224 19597341 19619488 19622404 19686080 19751508 19809470 19836308 19847258 19849719 20006983 20558317 20705860 20843316 20976471 21411632 22270359 22682247 22730322 23343194 23732914 24023259 25730849 26885856 7542250 7641885 8666229 9694792
RBX1 NEDD8 â—¼   ENZYMATIC_REACTION ✅ 61.0 1.0 ACSN 10023660 10671552 11348595 11900249 11955436 11967263 12051714 12648680 12820959 15001769 15071497 15340381 15459660 15688063 15703371 16039586 16697054 16713974 16940750 17143292 17652783 17884153 17928543 17936032 18196958 18805092 18931676 19250909 19258535 19270156 19352404 19366350 19411070 19576224 19597341 19619488 19622404 19686080 19751508 19809470 19836308 19847258 19849719 20006983 20558317 20705860 20843316 20976471 21411632 22270359 22682247 22730322 23343194 23732914 24023259 25730849 26885856 7542250 7641885 8666229 9694792
NFKB1 RBX1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9990852 10514433 9859996 9990853 7628694
NFKB1 SKP1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9990852 10514433 9859996 9990853 7628694
NFKB1 SOD1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 15317858 21725609 23178297 23572150
NFKB1 XIAP â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 17435549 21725609 23178297 23572150
NFKB1 NFKBIA â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 1829648 21725609 23178297 23572150 8096091
RELA NFKB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 16778171 20427719 23362108 16513645 1740105 20596645 16513841 19469019 8454856 21420936 16135789 9417120
NFKB1 XIAP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15041463 18223231 14739605 16157589 18978816 18761050 15756023 18566231 16453001
NFKB1 NFKBIA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17876798 15499023 17709515 7775482 11744993 10454561 11060311 12885753 9250151
NFKB1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 88.0 1.0 Omnipath 17145710 16209943 25609649 8428580 12947093 16970925 17072323 2050119 15657065 21270162 11976329 16793322 21544861 22261743 8657102 9824778 11880271 9450761 17962807 21988832 25355951 9722548 18215660 14743216 15799966 10799898 16105840 15218526 8798655 14690596 22139845 22808155 11571291 17072327 16740634 10498867 8255759 8246997 15214841 16846590 15371334 16285893 17072322 17855547 18321863 16493424 7479976 15145317 17561400 20110362 9426183 23687337 12414801 11970949 20154269 20237821 24175631 24634218 34100597 14645533 17982102 21763497 16204234 9437432 20547752 15818410 7628694
NFKB1 NFKBIA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 61.0 1.0 Omnipath 17145710 25609649 7862124 1340770 16210649 16970925 21719482 9738011 9865693 10497169 8657102 9572494 9315679 21988832 8887676 10329681 1829648 14743216 17003112 11313474 20558726 26496610 7867065 7891711 10837071 7831327 15836773 26186194 11571291 15214841 17561400 16846590 9566883 8096091 15371334 7479976 11020244 9426183 16493424 15145317 8631829 20237821 20980497 16513645 9597130 7479848 7739549 7628694 10655476
SKP1 NFKB2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9346238 15340381 16303288 8706131
RELA NFKB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9056676 9528780 15755876 7541912
NFKB2 RELB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 17145710 20126461 16551621 17072323 16970925 16793322 12709443 11687592 9681829 17962807 14743216 17254973 15218526 7925301 16108830 12927781 17561400 15371334 16285893 15145317 19098713 12505990 17548614 17072322
NFKBIA RBX1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9990852 10514433 9859996 9990853 7628694
RBX1 NFKBIA â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10066435 11900249 12648680 12820959 15071497 15340381 15459660 15688063 15703371 16697054 17884153 18931676 19150432 19270156 19622404 19686080 19809470 19847258 9859996
SKP1 NFKBIA â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10066435 11900249 12648680 12820959 15071497 15340381 15459660 15688063 15703371 16697054 17884153 18931676 19150432 19270156 19622404 19686080 19809470 19847258 9859996
REL NFKBIA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 7636983 8700518 8262046 16289774
RELA NFKBIA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 18204072 17876798 24083678 15499023 25759022 23422506 12859951 7775482 11744993 22723832 23450368 11060311 12885753 18981184 9250151
RELA NFKBIA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 134.0 1.0 Omnipath 17145710 15657065 11801607 25609694 15226358 17003112 9057089 26496610 19219072 23850221 7831327 12927781 16683270 17301240 17561400 9566883 10391945 8887633 16209943 21719482 10066434 8657102 10581242 29734393 21988832 12419806 14743216 16105840 15671248 9751059 9990853 25759022 10498867 8246997 7878004 11020244 9426183 15845455 26476452 23563313 16951195 25520503 9694722 11287411 10329681 15799966 17612295 24457201 10085161 10837071 10969074 11571291 9573251 15214841 16846590 20065107 7479976 24248593 8887627 15145317 16493424 9135156 24634218 7479848 15024091 14636585 26463447 7862124 1340770 22081069 8139561 27923823 16970925 9738011 9865693 9572494 11231305 14685242 20797629 11313474 16226509 14690596 22022389 21217772 26186194 30213788 15371334 8978697 20980497 7739549 7628694
SKP1 NFKBIA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 17145710 9990852 14743216 10066435 9990853 9859996
RBX1 TCEB1 â—¼   PHYSICAL_INTERACTION 21.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18420585 18931676 18985005 19622404 19622774 19686080 19809470 19847258
RBX1 RELA â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9990852 10514433 9859996 9990853 7628694
RBX1 SKP1 â—¼   PHYSICAL_INTERACTION 24.0 1.0 ACSN 11900249 12648680 12820959 14536078 15071497 15147722 15340381 15459660 15489953 15688063 15703371 16697054 17053147 17884153 18636226 18787170 18931676 19150432 19270156 19622404 19686080 19797085 19809470 19847258
RBX1 SKP1 â—¼   SHARES_COMPLEX 24.0 1.0 ACSN 11900249 12648680 12820959 14536078 15071497 15147722 15340381 15459660 15489953 15688063 15703371 16697054 17053147 17884153 18636226 18787170 18931676 19150432 19270156 19622404 19686080 19797085 19809470 19847258
RBX1 TCEB1 â—¼   SHARES_COMPLEX 21.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18420585 18931676 18985005 19622404 19622774 19686080 19809470 19847258
RBX1 SGK1 â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 11154281 11500365 11900249 12648680 12820959 15071497 15340381 15459660 15688063 15703371 16469695 16697054 17884153 18570873 18636226 18925875 18931676 19143635 19584721 19622404 19686080 19809470 19847258 20338997 20832730 26159692
SKP1 REL â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 10321728 9990852 10066435 9859996 10514424 10230406
SKP1 RELA â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9990852 10514433 9859996 9990853 7628694
SOCS1 RELA â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 10485906 12193701 12811837 14690596
RELA XIAP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15041463 18223231 14739605 16157589 18978816 18761050 15756023 18566231 16453001
SKP1 RELB â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9346238 15340381 16303288 8706131
UBE2M SKP1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 16647857 19617556 18826954 25349211 25314029 18206966 21940857 23201271 26906416 19250909 25531226 21863050