CKM
|
ASB9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
8153045
21516116
|
EMD
|
ACTB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
0020231
15328537
|
TP53
|
HNRNPK
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
8200620
21821029
|
SF1
|
HNRNPK
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
22365833
8293266
|
TP53
|
MLH1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15781865
|
OTUB1
|
SOD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
TP53
|
PPP1CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
15231748
5217094
|
TP53
|
YWHAE
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
18812399
8008642
|
TP53
|
PPP2R1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5219546
17245430
|
PAX8
|
TP53
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
8521821
|
TP53
|
TFAP2A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18980971
16636674
|
TP53
|
CHKA
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
9501176
10094833
|
TP53
|
DLST
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17916908
21191025
|
TP53
|
NDN
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10713459
10347180
|
TP53
|
CA9
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10760566
15199132
|
TP53
|
MAP1B
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
18656471
6700545
|
DLST
|
ARIH2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16169070
5217955
|
ARIH2
|
PPP2R1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16169070
5217955
|
ATP5PD
|
ATP5F1B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
000924
30021884
|
TRIM63
|
ATP5F1B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
18157088
6492033
|
GABARAP
|
HDAC5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16169070
5217955
|
TINF2
|
TERF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
11701125
5214767
|
DLD
|
BCKDHB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
2188967
10745006
|
PPP1CA
|
AKT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
8288823
20186153
|
PPP1CA
|
AKT1
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
8288823
20186153
|
PPP1CA
|
AKT1
|
â—¼ DEPHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
8288823
20186153
|
YWHAE
|
HDAC5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
10737771
5212359
|
GOLGA2
|
ATP6V1C2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
8153045
21516116
|
SOD1
|
LSM8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
SF1
|
ILF3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
22365833
8293266
|
POC1A
|
DLST
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
CDS2
|
TRIM63
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
31391242
233395
|
ACD
|
TRIM63
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
31391242
233395
|
TERF1
|
ACD
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
0605303103
16880378
|
VDAC1
|
AKR1B10
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
000924
30021884
|
TFAP2A
|
RBL2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11420667
8798715
|
H1-1
|
CNTRL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
000924
30021884
|
TFAP2A
|
ACADVL
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
14611808
10607478
|
ATP6V0A2
|
ATP6V1B1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
810.0
|
0.81
|
STRING
|
36370105
|
SOAT1
|
EMD
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
34079125
29128334
|
EMD
|
HDGF
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
21907836
17620012
|
RRP1B
|
C1QBP
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
20926688
19710015
|
RHOB
|
ADCY3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
34079125
31871319
|
RHOB
|
ACSL4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
34079125
31871319
|
ACOT2
|
ACOT1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
CHST8
|
C1QBP
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
PPP1CA
|
RRP1B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
834.0
|
0.83
|
STRING
|
36370105
|
NDN
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
836.0
|
0.83
|
STRING
|
36370105
|
CUL1
|
CUL3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
840.0
|
0.84
|
STRING
|
36370105
|
PPP1CC
|
RRP1B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
849.0
|
0.85
|
STRING
|
36370105
|
ATP6V0A2
|
ATP6V0C
|
â—¼ PHYSICAL_INTERACTION
|
|
|
857.0
|
0.85
|
STRING
|
36370105
|
EMD
|
ACTB
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
16189514
17620012
12670476
15328537
|
CUL3
|
CUL1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
21145461
26344197
|
HDAC6
|
ERBB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
20029029
31980649
|
EMD
|
LMNB1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
34079125
17620012
12670476
|
ASB9
|
CKM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
873.0
|
0.87
|
STRING
|
36370105
|
POT1
|
TERF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
873.0
|
0.87
|
STRING
|
36370105
|
AKR1C2
|
AKR1C3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
873.0
|
0.87
|
STRING
|
36370105
|
ACD
|
TERF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
874.0
|
0.87
|
STRING
|
36370105
|
CKB
|
CKM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
876.0
|
0.87
|
STRING
|
36370105
|
ACD
|
TERF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
28514442
15383534
15231715
16880378
26496610
33961781
26186194
|
RRP1B
|
ILF3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
29395067
33961781
19710015
|
HDAC5
|
YWHAE
|
â—¼ PHYSICAL_INTERACTION
|
|
|
889.0
|
0.89
|
STRING
|
36370105
|
HDAC5
|
YWHAQ
|
â—¼ PHYSICAL_INTERACTION
|
|
|
890.0
|
0.89
|
STRING
|
36370105
|
POT1
|
TINF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
897.0
|
0.89
|
STRING
|
36370105
|
TP53
|
MLH1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
18431400
15781865
|
PPP1CA
|
CAD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
4092695
|
TINF2
|
ACD
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
28514442
32296183
16189514
21044950
25416956
16713569
15383534
15181449
15231715
25910212
16880378
26496610
33961781
|
PPP1CC
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
14633703
|
ACP1
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
17353188
|
PPP1CA
|
PPP1CC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
899.0
|
0.9
|
STRING
|
36370105
|
ACD
|
TINF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
914.0
|
0.91
|
STRING
|
36370105
|
ATP6V0A1
|
ATP6V0C
|
â—¼ PHYSICAL_INTERACTION
|
|
|
922.0
|
0.92
|
STRING
|
36370105
|
ACSL3
|
ACSL4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.93
|
0.93
|
HIPPIE
|
22939629
26496610
|
ATP6V0A1
|
ATP6V1B1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
932.0
|
0.93
|
STRING
|
36370105
|
ATP6V1B1
|
ATP6V1E2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
934.0
|
0.93
|
STRING
|
36370105
|
ATP6V1B1
|
ATP6V1C2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
935.0
|
0.93
|
STRING
|
36370105
|
ATP6V1C2
|
ATP6V1E2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
937.0
|
0.93
|
STRING
|
36370105
|
TERF1
|
TINF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
937.0
|
0.93
|
STRING
|
36370105
|
TINF2
|
TERF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
28514442
17589526
15316005
21044950
15133513
25416956
19487455
15383534
15181449
16880378
10581025
26496610
20811636
28216227
33961781
26186194
16169070
11701125
|
ASB9
|
CKB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
990.0
|
0.99
|
STRING
|
36370105
|
ACD
|
POT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
997.0
|
0.99
|
STRING
|
36370105
|
TP53
|
CKM
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
8710368
9690516
7488858
12760745
9464547
8247545
8389468
9136900
7969181
9571041
7605578
|
HNRNPK
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
18472002
16360036
23092970
|
TP53
|
ADA
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
19861536
14647469
16410722
|
TP53
|
AKT1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
12485897
18661553
19763735
|
NDN
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
24722188
10347180
16713569
23785149
|
PPP1CA
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
16501611
16713569
15231748
15178317
|
MAPK13
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
15187187
19436832
15140942
10581258
20506250
21614932
16393692
24818748
11274345
|
PPP1CC
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
17145710
17274640
15178317
16501611
|
TINF2
|
POT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
14.0
|
1.0
|
ACSN
|
10581025
10850490
11349150
15231715
16166375
18680434
18828880
19454690
19965504
22064479
22634377
7502076
9326951
9822378
|
TINF2
|
POT1
|
â—¼ SHARES_COMPLEX
|
|
|
14.0
|
1.0
|
ACSN
|
10581025
10850490
11349150
15231715
16166375
18680434
18828880
19454690
19965504
22064479
22634377
7502076
9326951
9822378
|
ACD
|
TINF2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
25910212
16880378
15181449
25416956
21044950
15383534
31515488
26496610
16713569
15231715
|
CUL1
|
USP15
|
â—¼ PHYSICAL_INTERACTION
|
|
|
61.0
|
1.0
|
ACSN
|
10023660
10671552
11348595
11900249
11955436
11967263
12051714
12648680
12820959
15001769
15071497
15340381
15459660
15688063
15703371
16039586
16697054
16713974
16940750
17143292
17652783
17884153
17928543
17936032
18196958
18805092
18931676
19250909
19258535
19270156
19352404
19366350
19411070
19576224
19597341
19619488
19622404
19686080
19751508
19809470
19836308
19847258
19849719
20006983
20558317
20705860
20843316
20976471
21411632
22270359
22682247
22730322
23343194
23732914
24023259
25730849
26885856
7542250
7641885
8666229
9694792
|
CUL1
|
USP15
|
â—¼ SHARES_COMPLEX
|
|
|
61.0
|
1.0
|
ACSN
|
10023660
10671552
11348595
11900249
11955436
11967263
12051714
12648680
12820959
15001769
15071497
15340381
15459660
15688063
15703371
16039586
16697054
16713974
16940750
17143292
17652783
17884153
17928543
17936032
18196958
18805092
18931676
19250909
19258535
19270156
19352404
19366350
19411070
19576224
19597341
19619488
19622404
19686080
19751508
19809470
19836308
19847258
19849719
20006983
20558317
20705860
20843316
20976471
21411632
22270359
22682247
22730322
23343194
23732914
24023259
25730849
26885856
7542250
7641885
8666229
9694792
|
AKT1
|
CUL1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
45.0
|
1.0
|
ACSN
|
10722653
10949026
11274345
11715018
11756412
11756498
11923280
12408816
12906785
15169778
15808505
16469695
16697215
17052453
17461779
17680028
18000759
18372248
18492954
18570873
18636226
18925875
19022819
19143635
19151919
19568798
19720745
20027184
20138985
20214616
20338997
20398329
20832730
21157483
21474067
21981924
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
9812896
|
CUL1
|
PDCD4
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
18.0
|
1.0
|
ACSN
|
11900249
12648680
12820959
15071497
15340381
15459660
15688063
15703371
16697054
17053147
17884153
18931676
19270156
19622404
19686080
19797085
19809470
19847258
|
CUL1
|
USP15
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
61.0
|
1.0
|
ACSN
|
10023660
10671552
11348595
11900249
11955436
11967263
12051714
12648680
12820959
15001769
15071497
15340381
15459660
15688063
15703371
16039586
16697054
16713974
16940750
17143292
17652783
17884153
17928543
17936032
18196958
18805092
18931676
19250909
19258535
19270156
19352404
19366350
19411070
19576224
19597341
19619488
19622404
19686080
19751508
19809470
19836308
19847258
19849719
20006983
20558317
20705860
20843316
20976471
21411632
22270359
22682247
22730322
23343194
23732914
24023259
25730849
26885856
7542250
7641885
8666229
9694792
|
AKT1
|
CUL1
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
45.0
|
1.0
|
ACSN
|
10722653
10949026
11274345
11715018
11756412
11756498
11923280
12408816
12906785
15169778
15808505
16469695
16697215
17052453
17461779
17680028
18000759
18372248
18492954
18570873
18636226
18925875
19022819
19143635
19151919
19568798
19720745
20027184
20138985
20214616
20338997
20398329
20832730
21157483
21474067
21981924
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
9812896
|
PPP1CA
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
20186153
14633703
|
AKT1
|
PDCD4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
19.0
|
1.0
|
Omnipath
|
17053147
17081983
18296647
18187866
17287340
16357133
16964243
18669648
|
AKT1
|
ILF3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
20870937
18097023
|
AKT1
|
YWHAQ
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
18.0
|
1.0
|
Omnipath
|
20138985
15169778
9812896
17680028
11756412
11923280
20214616
16697215
10949026
10722653
20832730
18570873
18372248
11715018
20398329
17052453
18636226
15808505
|
AKT1
|
YWHAE
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
18.0
|
1.0
|
Omnipath
|
20138985
15169778
9812896
17680028
11756412
11923280
20214616
16697215
10949026
10722653
20832730
18570873
18372248
11715018
20398329
17052453
18636226
15808505
|
YWHAE
|
YWHAQ
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
21988832
20936779
20618440
17085597
21827211
12426317
15071501
12657644
17979178
|
TFAP2A
|
ERBB2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
19906305
10645007
7846046
22577344
18177484
15870067
9850080
10698518
16108032
11485026
18218085
12942124
|
ASB9
|
CKB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
9.0
|
1.0
|
Omnipath
|
19060904
25416956
27396830
16189514
32296183
25654263
17148442
|
THRA
|
CA2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
1682217
11889044
2126201
9857194
11314012
7916146
|