Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
KAT5 AR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10364196 5211544
AR KRAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8423674 24172884
AR INSR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20610535 20417685
AR RET â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20587519 11255259
AR CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24218937 20610535
AR MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14619959 20610535
AR ERBB3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21741601 20587519
EGR1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17011549 12890669
AR ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 15542423
STIM1 ATP2B4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8384259 22246182
HRAS CAV1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8621645 5220985
STIM1 CAV1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0905002106 19897728
CAV1 STIM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0905002106 19897728
MAPK1 CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17205132
EGFR NRAS â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
EGFR KRAS â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
EGFR HRAS â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
EGR1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11830539
EGFR HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 17673906
KRAS ERBB2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
NRAS ERBB2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
HRAS ERBB2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
ERBB2 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 17673906
ERBB3 FGFR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
ERBB3 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 17673906
STIM1 FGFR3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FGFR3 HAUS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
GRIN2C HAUS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
GRIN2C STIM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HRAS HAUS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
STIM1 HRAS â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
IGF1R INSRR â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
IGF1R YWHAG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
ITPR3 TRPV4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18826956 18378772
STIM1 KAT5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
KAT5 LMNA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
STIM1 OPTN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TRPC1 ORAI1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21408196 1001025
ORAI2 STIM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0904664106 19706554
ORAI3 STIM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0904664106 19706554
STIM1 PDIA3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8298334 21941299
STIM1 PDIA3 â—¼   COLOCALIZATION 2.0 0.8 intact 8298334 21941299
PDIA3 STIM1 â—¼   PROXIMITY 2.0 0.8 intact 8298334 21941299
STIM1 PPIB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RSL1D1 STIM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
STIM1 UBQLN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
STIM1 YWHAG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
STIM1 MARE1 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 34079125 23698468 19632184
LMNA SC22B â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 24623722 34079125
SC22B STIM1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22939629 34079125
STIM1 UB2J1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 34079125
S39A9 STIM1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
LRRT1 STIM1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
I17RB STIM1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
CCD40 STIM1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
CD1E STIM1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
EGFR IGF1R â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17047074 17307140
EGFR LMNA â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 24780295 26320552
IGF1R ERBB2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30898150 17307140
ERBB2 INSRR â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 30898150
HAUS1 STIM1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
KRAS MAPK1 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
METL6 STIM1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
STIM1 SARAF â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 22464749 30481768
TRPC1 STIM1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 21408196 19897728 22446186
ORAI3 CRCM1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 24954132 19887627
INSRR INSR â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 33961781 8916919
CAV1 TRPC1 â—¼   PHYSICAL_INTERACTION 844.0 0.84 STRING 36370105
KRAS NRAS â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
INSR INSRR â—¼   PHYSICAL_INTERACTION 851.0 0.85 STRING 36370105
IGF1R INSR â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
CAV1 INSR â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 31217420 10598578
HRAS NRAS â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
CAV1 EGFR â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
TRPC1 ITPR3 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 11290752 10980191 19052258
HRAS KRAS â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
CRCM1 STIM1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 22464749 24996186 19249086 21427704 22451904 24954132 21876174 20418871 19706554 22446186 30481768
EGR1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15517885 12890669
AR STIM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21432868 20610535
TRPC1 CAV1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 19897728 19052258 10980191 12732636
EGFR CAV1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 19446582 15657067 24658140 31980649 22411794 34079125 16407214 12354760 25402006 10781609 9374534 12388423 16799092 15273741
CAV1 PDGFRB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10066366 11168929 23331499
EGFR CDK1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 18271526 15657067 24658140 31980649 23956138 25402006
ERBB3 EGFR â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 23436906 10527633 27756321 21278786 18803307 17148612 22439932 25315821 10572067 24189400 23866081
EGR1 STIM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17307334 20123987
STIM1 ITPR1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 19249086 18596693 18187424
STIM1 ITPR2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 19249086 18596693 18187424
STIM1 ITPR3 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 19249086 18596693 18187424
STIM2 STIM1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11463338 28514442 33961781 34079125
ORAI1 STIM1 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
ERBB2 ERBB3 â—¼   PHYSICAL_INTERACTION 916.0 0.91 STRING 36370105
ERBB2 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 5218411 16516204
STIM1 ORAI1 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 24996186
STIM1 ORAI1 â—¼   COLOCALIZATION ✅ 0.96 0.96 mint 24996186
ORAI1 STIM1 â—¼   COLOCALIZATION ✅ 0.96 0.96 mint 21427704 8186898
ERBB3 ERBB2 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 22806884 25898135 30523157 9130710 21278786 15812817 20227043 16843263 10572067 19411071 19060928 8665853 10799311 8816440 17426253 17148612 21075308 12896906 15504738 23680147 23688700 23866081 22733765 7592681 21203579 25326665 24557338 23436906 30898150 7538656 25241761 25315821 11173924
EGFR ERBB3 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
EGFR ERBB2 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
AR EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 15305378 19318561 21613411 19258514 15650253 17242169 18692155 15288768 11556855 20610535
AR IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19318566 15033751 17202144 19250214 20610535
AR ATP2B4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20610535
KAT5 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11591700 10364196 19150978 11994312 16713569
MAPK1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 18511414 9725910 10318905
CDK1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 26573794 12569365 22275373 25704883 17043241 23321516 9725910 24480624 21799006 24424504 28062857 21820033 25950519 28415597 27450452 25691442 21782001
AR EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18358509 12534934 22260327 15288768 18951974
CAV1 EGFR â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 11102446 17517963 18458534 19411448 20855962 21051947 21150282 21729786 22411312 22874531 23907124 25364523 26828520
INSR CAV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9756945 10598578 12036959 17699617
EGFR CAV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 17145710 31980649 22411794 9374534 19446582 16799092 12388423 15657067 24658140 19625610 16407214 18789131 25402006 15951569 10781609 16332692
CAV1 PDGFRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 18988627 16189514 10066366
CAV1 TRPC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 14551243 10980191 16822931 19351713 18430726 19052258 12732636 19897728
LMNA CDK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 22986494 2188731 2344612 2188730
ERBB2 CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 55.0 1.0 Omnipath 18927589 17938195 10770932 17276342 17396146 11836499 17409144 29088738 19276355 26673326 19933706 28335434 20372791 7743995 11322924 19683496 27889260 17466630 14681223 12384528 12049736 7841526 12110582 25744022 18393321 15582998 19861462 14987992 20144215 17466629 16546994 19858290 15136770 14767478 20368335 25994202 10504341 1850698 15350223 24910099 9268380 15296723 8428596 24391510 18469858 8662825 20530684 11782384 15141014 15940258 12766774
CDK1 LMNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 80.0 1.0 Omnipath 19007248 16565220 20166139 17081983 18767875 20393185 23870088 17137347 19413330 18187866 19194518 30190500 19664995 19415658 15302935 7925482 16083285 95010153 24741066 20068231 18452278 18077418 17570479 18491316 18669648 32071079 23427156 2344612 18691976 26922519 17287340 18815303 20068230 19651622 20058876 19691289 17924679 22367880 19165338 19664994 18707149 21389115 16964243 18212344 24556839
CDK1 STIM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19881501 22748319
CDK1 KAT5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 21658600 12468530 16103124 17570479 26829474 18669648
CDK1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 17145710 31980649 8360196 23956138 15901825 28150246 18271526 15657067 24658140 25402006 15302935
EGR1 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16750517 15863471 23763269 16170359 11830539 17230532
MAPK1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 12556561 1651322 17081983 3138233 15901825 1939237 91332050 2543683 2115882 17192257 1651323 15302935
EGFR ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 65.0 1.0 Omnipath 17081983 16207817 21044682 17148612 24557338 16713569 21203579 10233167 20471394 17389395 17486068 21278786 11500516 11279155 11500850 17426253 16843263 19650109 25241761 24189400 15657067 17307140 18803307 1706616 12354693 10572067 24355130 11408594 19060928 12648464 16516204 15951569 23436906 20211985
EGFR ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 17145710 23436906 7929151 21278786 24189400 23866081 17148612 12648464 27756321 18803307 10527633 10572067 22439932
ERBB2 ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 44.0 1.0 Omnipath 17145710 23680147 17148612 24557338 19411071 21203579 7592681 23688700 23331499 21278786 12648465 22806884 27531070 17570479 30898150 29066975 17426253 16843263 9130710 20227043 25241761 10799311 8816440 22733765 10572067 19060928 11173924 21075308 23436906 7538656 15504738
NRAS ERBB3 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 Reactome 23220880 25853726 30301790 28274957 18039657 16843263 25994018 26545934 22046346 18413839 23948973 26375550
KRAS ERBB3 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 Reactome 23220880 25853726 30301790 28274957 18039657 16843263 25994018 26545934 22046346 18413839 23948973 26375550
HRAS ERBB3 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 Reactome 23220880 25853726 30301790 28274957 18039657 16843263 25994018 26545934 22046346 18413839 23948973 26375550
NRAS FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
KRAS FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
HRAS FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
FGFR1 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MAPK1 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 27342992 23405013
FGFR3 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
HRAS MAPK1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
IGF1R YWHAG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12767520 10826997 12444011 21540285 17145710 17353931 19030972 16931767 15324660 12175651
ITPR2 TRPC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 15121806 16870612 18249094 17681754 23228564 12196544 18068335 11336651 18191041 16905188 10970773
NRAS MAPK1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
RET MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 47.0 1.0 Omnipath 19901323 11522789 91184134 16156666 16497976 15592455 12571246 19415658 11826406 17389395 18578522 21109534 20068231 18452278 18669648 16153436 11522288 18691976 1378617 15972258 15935618 16094384 12388769 11971971 19651622 21842857 28450419 18707149 17016520 21455180
MAPK1 STIM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 25562429 22298426 23687376 24114840 19881501 33023909 25447552 28935720
STIM1 ORAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 21876174 21427704 22446186 19249086 35439114 24954132 24996186 22451904 22464749 19706554 30481768
PDGFRB PDGFRA â—¼   PHYSICAL_INTERACTION 5.0 1.0 ACSN 15099563 17145802 17496910 18633355 24359404
PDGFRB PDGFRA â—¼   SHARES_COMPLEX 5.0 1.0 ACSN 15099563 17145802 17496910 18633355 24359404
PDGFRB PDGFRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 23331499 21071413 2161888 2542288 7523122 1847074 16189514 11331882 10417313
STIM1 TRPC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 24464579 18430726 18326500 16906149 19897728 22592407 23686296 18802022 18644792 19332490 20488539 21408196 22446186 23395841 17892531 16870612 17224452 18249094 25013939 23034388 20194530
TRPV4 TRPC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 25114176 21871867 20705915 25139746 20093626
TRPC1 TRPV4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 25114176 21871867 20705915 25139746 20093626