Protein list:

Seperate proteins by space | Example

Select nodes using shift click or drag to add to this list
Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

Note this may take some time with > 30 proteins
Filter Graph:

0.5
Layout:
  🔂

Click a node or edge for more data...
Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
AGTR1 AP2M1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
AP2S1 AP2M1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15749704 15911768
MAPK1 AP2M1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10608864 10818153
AP2M1 AP2A1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15749704 15911768
AP2M1 AP2A2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15749704 15911768
AP2M1 AP2B1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15749704 15911768
AP2S1 AP2M1 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15749704 15911768
AP2M1 AP2A2 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15749704 15911768
AP2M1 AP2A1 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15749704 15911768
AP2M1 AP2B1 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15749704 15911768
ATF2 RHOB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11160903 21565167
EGFR NRAS â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
EGFR KRAS â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
EGFR HRAS â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
EGFR HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 17673906
EGFR PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 1845983
AP2A1 MAPK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10608864 10818153
AP2A2 MAPK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10608864 10818153
MAPK1 AP2S1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10608864 10818153
MAPK1 AP2B1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10608864 10818153
RAF1 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 20674547 15664191
MAPK1 MAP2K1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 23241949 8412360
PRKCE MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11350735
PRKCB MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8903320 10327068
HGF MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16397249 17667909
PPP1CA MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12624094 12840032
MYC CCK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MYC SLC2A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10823814
AKT1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17942906 9804616
GATA4 MYH7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10998641 10212267
ATF1 ATP1A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9016641 7659506
PRKCA ATP1A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17570479 14976217
CCK PPARA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SLC25A5 NFKBIA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HGF PTK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10521801 16782899
HGF PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10871282 10648629
PLCG1 AGTR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 9516477 6730883
PLCG1 FGFR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16844695 10652257
PLCG1 KL â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16844695 10652257
RAP1A RAF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7791872 5220596
YWHAQ RAF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11697890 8005785
RAF1 AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19197339 7014125
RAF1 RAP1B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8253074 9115221
PRKCE RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11350735
RAP1A PTK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11476890 16919435
AP2B1 AP2A2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15749704 15911768
AP2S1 AP2A2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15749704 15911768
AP2A2 AP2A1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15749704 15911768
AP2B1 AP2A2 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15749704 15911768
AP2S1 AP2A2 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15749704 15911768
AP2A2 AP2A1 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15749704 15911768
AP2S1 AP2B1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15749704 15911768
AP2B1 AP2A1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15749704 15911768
AP2S1 AP2B1 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15749704 15911768
AP2B1 AP2A1 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15749704 15911768
AP2S1 AP2A1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15749704 15911768
AP2S1 AP2A1 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15749704 15911768
ROCK1 PPP1CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19306866
GATA4 FGFR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21379568 19053175
PPP1CA AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8288823 20186153
PPP1CA AKT1 â—¼   COLOCALIZATION 2.0 0.8 intact 8288823 20186153
PPP1CA AKT1 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 8288823 20186153
FGFR2 PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15863030 11353842
PRKCA PRKCE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16810323 5218785
PRKCA CACNA1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8380626 9278528
PRKCA VASP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14706852
RAP1B PTK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11476890 16919435
GRIA3 GRIA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0708699104 17989220
ITPR1 PDE5A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18757735 0804738105
PDE5A ITPR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18757735 0804738105
PRKACB GLI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19996099 20027184
PRKCE ADCY7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17185372
PRKCE ADCY5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17185372
PIK3CA KL â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15863030 11353842
NPR2 NPPC â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15146390 1672777
PLCB2 PLCB1 â—¼   PHOSPHOLIPASE ✅ 2.0 0.8 Reactome 11015615 2841328
PPARA AGT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15067378 20613959
PPARA ACOX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20813756
ADRB2 YWHAQ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
GATA4 AGTR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9207128 10579051
GABBR2 GABBR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218685 16724110
ATF1 SST â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1655749 10766345
AGTR1 YWHAQ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
ADRA1A TPCN2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
ADRA1A SCN1B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
AGT AGTR2 â—¼   UP_REGULATES ✅ + 0.81 0.81 Signor 16597412
RHOB EGFR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
MYC AP2A1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17353931 29467282
RHOB PLD1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
ROCK2 ROCK1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
FGFR2 FGFR1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
AKT3 AKT1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
RHOB ADCY9 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
GRIA2 GRIA3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 14687553 17989220
RHOB FLOT2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
RHOB DLG1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
RHOB ADCY3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
RHOB STOM â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
HRAS RASSF1 â—¼   PHYSICAL_INTERACTION 820.0 0.82 STRING 36370105
KRAS MAPK1 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
EGFR AP2S1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 24797263 25754235 24189400
EGFR PLCG1 â—¼   PHOSPHORYLATION ✅ + 0.84 0.84 Signor 1689310
FGFR1 KL â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
MYH7 MYL2 â—¼   PHYSICAL_INTERACTION 845.0 0.84 STRING 36370105
AGT AGTR2 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
MAPK1 RAF1 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
MYH7 MYL3 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
KRAS NRAS â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
ATF2 ATF1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 25609649 26344197 31964530
PLCG1 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 9020117 6805619
EGFR AP2B1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 24797263 24189400 7534311 23956138
EGFR AP2A2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 24797263 8548289 24189400 23956138 31959764
RHOB ROCK1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 34079125 31871319 34187934
AKT2 AKT1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 28514442 12149249 9736715 12176337 11445557 33961781 14500673 11278835 11546794
PDE5A PRKACB â—¼   PHYSICAL_INTERACTION 849.0 0.85 STRING 36370105
MYL2 MYL3 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
ADRA1D SNTA1 â—¼   PHYSICAL_INTERACTION 858.0 0.85 STRING 36370105
SLC25A4 SLC25A5 â—¼   PHYSICAL_INTERACTION 858.0 0.85 STRING 36370105
APBB1 VASP â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 34079125 16055720
ITPR1 AKT1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 24947355 18250332
AKT1 NOS3 â—¼   PHOSPHORYLATION ✅ + 0.86 0.86 Signor 24379783
ADORA1 GNAI2 â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
EGFR RAF1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24658140 25402006 31980649
AP2A1 AP2B1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 34079125 33961781 26344197
HRAS PIK3CA â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
NRAS RAF1 â—¼   RELOCALIZATION ✅ + 0.87 0.87 Signor 21779497
HRAS NRAS â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
EGFR AP2A1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 24797263 20029029 24189400 23956138 25754235 7534311 31959764
AP2A2 AP2B1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 12086608 16189514 33961781 34079125 26344197
AKT1 RAF1 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
AKT1 PIK3CA â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
AKT1 NOS3 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
NPPC NPR2 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
EGFR PIK3R2 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
AP2A1 AP2B1 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
AKT1 PPP2CA â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
EGFR AP2M1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24797263 20029029 31980649 24189400 23956138 24067654 25754235 31959764
AP2M1 AP2S1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 24189400 33961781 26186194 19380743 26344197
AP2M1 AP2A2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 24189400 33961781 26186194 19380743 26344197
AP2M1 AP2A1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 24189400 33961781 26186194 19380743 26344197
EGFR AKT1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24658140 25402006 31980649
AP2S1 AP2B1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 12086608 16189514 33961781 34079125 26344197
FLOT1 FLOT2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17113085 30021884 34079125 22939629 24167781 24809731
HRAS KRAS â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
CASK DLG1 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
AP2B1 AP2M1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 12086608 16189514 16713569 24189400 33961781 19380743 26186194 30021884 34079125 26344197
ATF2 NOS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16497991
EGFR PLCG1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 1689310 11983899 14568990 15144186 12803489 12601080 24797263 9756944 9207933 19605547 7993895 7693694 9020117 12061819 16273093 25754235 16713569 22973453 7682059 8657103 8885868
GATA3 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19559773
MAPK1 RAP1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 27503831 16939974 9560161
MAPK1 MAP2K1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 10567369 19219045 8013650
PPP1CA MAPK1 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 intact 211739200 12840032 8214413
PPP2CA MAPK1 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 intact 211739200 12840032 8214413
MAPK1 GATA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11585926
MAPK1 ATP1A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15069082 14976217
MYC RAF1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17314511 9315742 28628118 28205554
MYC FGFR4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16846534 16489011 18562319
MYC NRAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC CXCR4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10229837 11145693
MYC ACOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC CST5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC ADCY9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
MYC ATP1A2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
ROCK2 MYL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25412762 22120626
PLD1 PLCG1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 8024366 19323535 7215275
PIK3R2 PDGFB â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 2466336 1374684 9739761
PDGFB PIK3CA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 2466336 1374684 9739761
PDGFB PLCG1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 1396585 8443409 9739761
PLCG1 FGFR1 â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 8321198 6730542
FGFR1 PLCG1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12601080 1689310 1656221 25241761 23063561 8321198 9660748 20932831 18022941 19665973 15117958
FGFR2 PLCG1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15629145 24440983 25241761 7999363
FGFR1 PLCG1 â—¼   PROXIMITY ✅ 0.9 0.9 mint 8019672 20932831
PLCG1 FGFR1 â—¼   PROXIMITY ✅ 0.9 0.9 mint 8019672 20932831
RAF1 PPP2CA â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 502464200 8203796 16239230
AKT1 RAF1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 25241761 28628118 10576742 19197339 19058874 28205554
RAP1A RAF1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 7791872 16189514 9115221 10454553 8756332 7862125 9867809 9564038
RAF1 PPP2CA â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 intact 502464200 8203796 16239230
PPP1CA RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7604263 16630891
RAP1A MAP2K1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 27503831 16939974 9560161
PPP2CA PRKCA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10592173 9675027
PRKCA ADCY5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8206971 7759492
PTK2 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11119718 10592173 7537275
PPP2CA VASP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 7656973 8836115
PPP1CA NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19036824
PPARA NOS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14751809 16842672 17105827
GATA3 ATOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19559773
GATA4 NOS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14555463
CREM FSHB â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21659477 10209256 20008557
ATF1 CGA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11014230 10341006
AKT3 NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24379783
KCNQ1 KCNE1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19521339 24713462 11101505 11104781 19114714
GATA3 SST â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19559773
GATA3 ATP2B1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19559773
AKT2 NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24379783
STOM SLC2A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10562431
RAF1 YWHAQ â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
FLOT1 FLOT2 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
RHOB ROCK2 â—¼   PROTEIN_INTERACTION 0.91 0.91 HIPPIE 34079125 31871319
DLG1 DLG3 â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 33961781 12351654 26496610
EGFR PLCG1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
NRAS RAF1 â—¼   PROXIMITY ✅ 0.93 0.93 mint 30194290
SNTA1 SCN5A â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 9412493 18591664
NRAS RAF1 â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
RAF1 MAP2K1 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 7014125 19197339
AP2S1 AP2A1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 31353312 16189514 7593184 33961781 26344197
FGFR2 PLCG1 â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
GRIA2 GRIA3 â—¼   PHYSICAL_INTERACTION 967.0 0.96 STRING 36370105
AP2A1 AP2M1 â—¼   PHYSICAL_INTERACTION 969.0 0.97 STRING 36370105
AP2S1 AP2A2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 33961781 26344197
MAP2K1 RAF1 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
AP2A1 AP2S1 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
KRAS RAF1 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
CGA FSHB â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
MAP2K1 MAPK1 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
ATP1A1 ATP1B1 â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
FGFR1 PLCG1 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
HRAS RAF1 â—¼   PROXIMITY ✅ 0.98 0.98 mint 18273062 6540139
RAF1 HRAS â—¼   PROXIMITY ✅ 0.98 0.98 mint 18273062 6540139
AP2A2 AP2B1 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
RAF1 RAP1A â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
PIK3CA PIK3R2 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
GABBR1 GABBR2 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
AP2B1 AP2S1 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
AP2A2 AP2M1 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
AP2B1 AP2M1 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
AP2M1 AP2S1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
AP2A2 AP2S1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
PPP2CA PPP2R3B â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CLTB AP2M1 â—¼   PHYSICAL_INTERACTION 16.0 1.0 Reactome 1847920 20448150 10559856 19713939 19776351 21883765 15916959 26403691 22863004 23891661 19809571 21445324 15339664 21613550 21779028 19296720
AP2M1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 23956138 31980649 24189400 19351721 20029029 24797263
MAPK1 APBB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 14697653
ATF2 RAF1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 11274345 12738796 18039929 20506250
MAPK1 ATF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 10777545 17081983 21098032 9430721 12110590 20068231 19690332 15304344 19413330 10878576 15192015 7737129 18669648 19647037
MAPK13 ATF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 15187187 19436832 9207191 10581204 15140942 20506250 21614932 19135240 16393692 12244047 11274345
PRKCA ATF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 1661585 9436983 19176525 92095966
PRKCE ATF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 24727247 22304920 24357804 25545367 26645581 25728676
PPP2CA EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18039929 16680151 10995457 18042541 18588945
MAPK1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 12556561 1651322 17081983 3138233 15901825 1939237 91332050 2543683 2115882 17192257 1651323 15302935
PRKCE EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 33.0 1.0 Omnipath 11447289 21749319 8321321 11313945 12359306 25402006 12040186 23830194 6321473 1860884 27016036 6090944 19568798 14585353 17496910 21386996 17942932 20692258 24658140 1556153 2984676 18042729 11940581 11185568 19615955 2987962 23205726 12845332 10816576 3379075 15567848 16488589 16793002
PRKCB EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 17496910 11940581 21386996 11447289 19615955 16488589 6321473 8321321 12845332 11313945 7805884 17570479 12040186 19568798 15567848 14585353
PRKCA EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 39.0 1.0 Omnipath 11447289 8321321 11313945 25402006 12040186 20888375 15302935 6321473 1860884 12878187 6090944 19568798 14585353 17496910 21386996 24658140 2984676 11940581 31980649 15212693 85012702 19615955 2987962 12845332 3379075 7805884 10816576 15567848 16488589
EGFR PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 89.0 1.0 Omnipath 19901323 17081983 16273093 9207933 2472219 16497976 15592455 16126727 16713569 24797263 17389395 8578591 23331499 7991458 1689310 20068231 17570479 9176240 12803489 16153436 7993895 16038803 7805859 15864276 1708307 7682059 15144186 11983899 12601080 9756944 15212693 14568990 12061819 9020117 8885868 12648464 8657103 15951569 17016520 7693694
EGFR PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 17496910 31980649 23956138 19531499 16273093 24658140 11172806 1334406 25402006
EGFR PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 16713569 16919435 25402006 10806474 29435030 20473329 7657702 19339212 17496910 15657067 24658140 19625610 7529872 20802513 31980649 10545505 24043698 15951569
EGFR MAP2K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12556561 15531749
NRAS MAPK1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
RAF1 MAPK1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 25435214 20179705 20141835 16364920 20130576 15035987 25907612
HRAS MAPK1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
FGFR4 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
FGFR1 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
FGFR2 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MAPK1 KL â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MYC MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22789855 21933022 16596619 23617883 8013639 20144848
PRKCA MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11704645 12598525 19074803 8903320 9160888
PPP2CA MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 12624094 12840032 18039929 16680151 16456541 10995457 18042541 10592173 7780739 18588945 2154696 20626350
MAP2K1 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 149.0 1.0 Omnipath 21675959 9694850 17081983 10757792 11319218 18799465 15592455 12788955 19415658 12697810 17389395 9447970 15342917 8226933 15851026 12270934 12644307 17255949 10998418 11242034 1378617 1381507 17906627 11986622 8376945 8157000 7992057 11948414 9731057 19651622 11251083 11266467 18707149 14743221 11279118 11704645 12750173 12932319 16497976 11337027 23331499 12048245 7559390 17272394 15811950 19494114 18669648 18691976 11741894 15972258 19053285 16094384 17192257 7898932 24623782 9166761 19369195 21336309 12920017 15466214 17016520 19901323 1712480 19690332 11823456 9032297 11134045 12876277 19534553 10995751 20068231 21506533 8223433 8248196 16153436 12594221 10567369 19933846 17563371 11730323 29175850 11352917 16135787 15951569 19058874 15212693 23241949 9560161 91184134 18083107 16887817 18578522 17569879 21071413 9148935 18452278 1330321 8670897 19541618 10777511 15935618 12925710 11971971 9765155 11136732 11118451 12082107 12952943 10746662 21768338
MAPK13 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12738796 18039929 11274345 15187187
MAPK1 RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 43.0 1.0 Omnipath 17081983 18767875 15849194 19690332 11409918 14654779 23331499 23180781 8226933 20068231 18988627 21917714 18669648 19541618 18691976 16407412 19933846 9922370 15664191 8388392 19651622 10801873 8349614 18775330 9604935
MAPK1 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 27342992 23405013
MAPK1 LIPE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11581251
MAPK1 PLCB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11287604 11481231
MAPK1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 10551811 17081983 8386367 17251036 91332050 17570479 1748630 7957875 27167001 15212693 1651323 15210690
MAPK1 PPARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10187842
MYC ATF4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12695333 23612979
PPP2CA MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19131971 10026142 10995457 18042541 18559511 16680151 15048125
HRAS RASSF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 16810318 17145710 18596699 32814053 10998413
PRKCA PLD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 1559964 11459228 9989263 11042115 12429840 17570479 10441128 12839565
FGF16 FGFR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16597617 25772309
FGF16 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16597617 25772309
FGF16 FGFR4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16597617 25772309
PPARA NFKBIA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12393563 14713228 14976045 19438714 10980195 11981037
PLCG1 FGFR4 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 19147536 16091734 10652257 10918587 19749790 18337450 16844695
PRKCA PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 2820980 8885868 10592173 1370476
FGFR2 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 12601080 17081983 7999363 16038803 1689310 1708307 7682059 15144186 8885868 16126727 15592455 8657103 16153436 24440983
FGFR4 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 17496910 12601080 17081983 16038803 1689310 1708307 7682059 15144186 8885868 16126727 15592455 8657103 16153436 7518429
FGFR1 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 17081983 20932831 1656221 16126727 15592455 9660748 19665973 7991458 1689310 8321198 8050374 16153436 17496910 25241761 16038803 10459043 23063561 1708307 7682059 15144186 12601080 9052794 8885868 8657103 15212693
PTK2 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 8660853 26278977 10430888 23397142
HRAS RAF1 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
RAF1 HRAS â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 10358164 11532940 12566895 14764585 15516985 16102570 19289794 19565474 24027568 7510700 8551221 9069260 9763606 9846483
RAF1 HRAS â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 10358164 11532940 12566895 14764585 15516985 16102570 19289794 19565474 24027568 7510700 8551221 9069260 9763606 9846483
RAF1 HRAS â—¼   ENZYMATIC_REACTION ✅ 14.0 1.0 ACSN 10358164 11532940 12566895 14764585 15516985 16102570 19289794 19565474 24027568 7510700 8551221 9069260 9763606 9846483
KRAS RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 53.0 1.0 Omnipath 10958680 12750173 9516156 12932319 9665134 10783161 8805624 1386920 1639773 8340422 8601312 19595761 23331499 16041367 21071413 8332195 9446616 10882715 25852190 10531446 1996324 19029954 8503013 16093354 19541618 23153539 16293107 1708096 19933846 26721396 11136732 10205168 20802526 31980649 7760835 18775988 8307946 12917261 11134016 20080631 8180183 1990291
AKT1 RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 51.0 1.0 Omnipath 19197339 11971957 18767875 20230923 10576742 20068231 17570479 16189514 18669648 25241761 18691976 10576741 10618391 20688159 21745501 12087097 12801936 12048182 22798428 16854453 19058874 11997508
RAP1A RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 9867809 9115221 7791872 12446733 8756332 16189514 7862125 12873387 10454553
HRAS RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 147.0 1.0 Omnipath 17145710 18273062 9523700 1639773 8601312 19595761 20133694 11032808 9154803 10882715 14654780 1996324 19222999 16301319 11948414 8530446 7969158 11313862 9150145 20080631 1990291 12750173 15031288 12932319 9665134 8805624 8340422 1386920 23331499 16916524 16041367 23180781 18988627 20178605 15688026 15664191 22169110 11733498 7862125 8180183 19063885 12391160 9144171 8035810 9020159 14724584 19696784 21779497 9261098 12173045 12620389 8628317 19914712 1708096 19933846 26721396 7730360 10205168 8332187 16803888 18775988 12917261 9099670 10545207 25684575 8670882 10783161 12379659 10887184 17569879 21071413 8332195 7523381 10531446 24929361 8503013 16093354 19541618 10369681 8911690 18073111 11136732 10922060 7760835 11134016
PRKCB RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8288587 1386920 12917261 22826029
YWHAQ RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 17145710 14688280 7760835 17353931 16041367 11697890
PRKCA RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 1386920 23331499 9447975 8321321 12551925 8288587 7935389 12917261 9922370 15664191 93309588 1437148
PPP2CA RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18039929 7604263 16680151 16239230 10995457 18042541 18588945
NRAS RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 46.0 1.0 Omnipath 9867809 12750173 12932319 9001246 9665134 8805624 1386920 1639773 8340422 8601312 19595761 23331499 21071413 8332195 10531446 10882715 7811320 1996324 18988627 21779497 8636091 8503013 7766599 16093354 19541618 8180183 1708096 19933846 32296183 9525741 8876196 11136732 10205168 21478863 7760835 18775988 12917261 11134016 18641128 20080631 9488663 1990291
RAF1 YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17145710 14688280 7760835 17353931 16041367 11697890
RAF1 MAP2K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 143.0 1.0 Omnipath 10757792 18337766 18799465 15342917 23728975 26496610 15866172 17053865 11242034 9351825 9677429 8157000 7992057 11948414 11604401 16129686 10677502 12695496 19197339 7565670 12750173 7936666 1326789 19219045 23331499 18556463 10976102 18988627 15485920 15175348 18691976 16407412 10409742 9311917 17192257 7898932 8621729 23934108 11684694 21336309 7624324 12920017 11948406 15466214 11042690 12907640 9032297 27169363 12876277 8933152 8223433 8248196 8131746 12594221 10969079 10567369 17979178 17724343 24746704 19058874 10958680 8090753 21071413 7731720 7873542 1330321 8503013 16093354 19541618 8394352 15466476 25155755 11136732 9069260 94178255 8607979 10327068 10359597 8039496 20212043
PIK3R2 HRAS â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
HRAS FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
HRAS FGFR4 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
HRAS PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 9069260 9113989 8052307 24412244 17540175 9931431 11313862 14724584 10592173 9150145 8665852 10783161
HRAS AFDN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17145710 10334923 10922060 8557659 10545207
RAP1A AFDN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10922060 10224125
AP2A2 CLTB â—¼   PHYSICAL_INTERACTION 16.0 1.0 Reactome 1847920 20448150 10559856 19713939 19776351 21883765 15916959 26403691 22863004 23891661 19809571 21445324 15339664 21613550 21779028 19296720
RHOB ROCK1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11283606 15699075 8816443 11294240 8617235
ROCK1 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 9182576 22348083 16254240 15247219 16760434 10744763 17745990 7529876 12960434
CXCR4 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11668182
CXCR4 GNAI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520
FGFR1 PIK3CA â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 17505008 18757403 21666749 11689702 21711248 11739186 21160078 14534538 15448205
KRAS FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
NRAS FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
FGF18 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10751172 16597617 25772309
PRKCE FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 17496910 11940581 21386996 11447289 19615955 16488589 6321473 8321321 12845332 11313945 23564461 12040186 19568798 15567848 14585353
FGFR1 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17496910 15117958
PIK3CA AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 25793261 19117013 21041639 24950409 21816939
PPP2CA AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 35.0 1.0 Omnipath 21159657 26256536 15743829 10026142 20452955 11438723 18559511 11839802 19996169 19216069 16406523 10995457 18042541 19556239 18588945 16680151 11087733 18160256 15367694 18039929 18077353 11812651 16044149 20360384 12637511
PPP1CA AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20186153 14633703
AKT1 NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 70.0 1.0 Omnipath 12759249 20166139 11756412 10376603 11923280 12446767 16697215 11044445 20398329 18372248 11696579 16126727 16839566 15808505 20138985 20299462 10908731 20363286 11988487 11425855 20214616 23103584 11729179 16043647 17570479 12171920 25460366 27322328 11978735 15169778 11029403 25241761 19654415 10949026 18048761 11715018 12791703 24379783 18636226 9812896 23397142 17680028 10376602 12431978 10722653 20832730 18570873 25009123 17052453
AKT1 ITPR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 24947355 18250332 16332683 18955969
AKT1 AKT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11546794 14500673 12176337 11445557 9736715 12149249 11278835
AKT1 YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 20138985 15169778 9812896 17680028 11756412 11923280 20214616 16697215 10949026 10722653 20832730 18570873 18372248 11715018 20398329 17052453 18636226 15808505
AKT1 MST1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 12919677 14505491
AKT1 ADRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11809767 9032240
FGF18 FGFR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 10751172 16597617 8663044 25772309
PRKCE FGFR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 17496910 11940581 21386996 11447289 19615955 16488589 6321473 8321321 12845332 11313945 23564461 12040186 19568798 15567848 14585353
PRKCA NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 33539947 25814956 12384459 27191895 18622039 27106139 12574113 12869534 21797845 11729179 21757745 25020117 28833096 12644458 24612481 24379783 16527893 16527820 12952971
PRKCA ADRA1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 9353340 17570479
PRKCA AQP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22334691 17522053
PRKCA ADCY2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 8383119 8900209 9366262 7938004 9268695
PRKCA PLCB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 9015864 11278470 9349568 2211670 9307019 17570479 21338571
PRKCA ATP2B1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 9824678 11779484 1827443
PRKCA KCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17570479 1553557
PRKCA KRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 20802526 34333552 23331499 25713064 27791178 18458061 9922370 18182391 16483930
AP2A1 CLTB â—¼   PHYSICAL_INTERACTION 16.0 1.0 Reactome 1847920 20448150 10559856 19713939 19776351 21883765 15916959 26403691 22863004 23891661 19809571 21445324 15339664 21613550 21779028 19296720
PTK2 ATP2B4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 25847233 9182531 12540962
ADCYAP1 ADCYAP1R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 8703026 16930633 12488235 10583729 11931347 21350482 10100920 17470806 8253796
GNAI2 ADCY6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 23109003 15539636 7935349 16460834 11376933
GNAI2 ADCY1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 2121366 8327893 19703466
GNAI2 ADCY5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 23109003 15539636 7935349 16460834 11376933
PPP2CA AKT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 15367694 18039929 19216069 10026142 10995457 18042541 20452955 18559511 18588945 16680151 16406523 18160256
PPP2CA MAP2K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 18039929 16680151 1716348 10995457 18042541 18588945 20626350
PPP2CA PRKCB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 15880462 8749392
PPP2CA AKT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 15367694 18039929 19216069 10026142 10995457 18042541 20452955 18559511 18588945 16680151 16406523 18160256
GLI3 PRKACB â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17283082 16705181 20154143 16371461 16611981
PRKCE NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20350291 24379783
FGFR4 PIK3CA â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 17505008 18757403 21666749 11689702 21711248 11739186 21160078 14534538 15448205
NRAS PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8052307 7820549 9150145 8665852 21779497
KRAS MAP2K1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
NRAS MAP2K1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
NPPC NPR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 1309330 12709393 11952095 29934642
PIK3R2 KRAS â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
KRAS FGFR4 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
AGT AGTR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 12006574 21464395 10193788 10993080 16189514 15930094 9797979 16597412 17346243
AGT AGTR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 2775266 21464395 8315512 21542804 17138938 8185599 15930094 9797979 8242249 7850406
PIK3R2 NRAS â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
PPARA ACOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8567672 7635967 9556573 20110263 16828988
GLI3 PTCH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 19860666 17419683 28533268 24276242 10077605 16571352 15087129
GLI3 PTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 21234400 20562908 9216996 19032343 12435627 16406505 19114989 16880536 16054035 11001584 17000779 16169709 16413481 15087129 16396903 19809516 20107231
NRAS FGFR4 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
CGA LHCGR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 10342833 12727981 1922095
PPP2R3B AKT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 18039929 19216069 10026142 10995457 18042541 20452955 18559511 18588945 16680151 16406523
PRKCB NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 24379783 24790142
FGF18 FGFR4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10751172 16597617 25772309
ROCK2 RHOB â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11283606 15699075 8816443 11294240 8617235
MST1R YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 12919677 14505491