Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
ESR1 BMI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24559156 16582100
CHEK2 MDC1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 16651405 10724175
GRB2 DBN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
DBN1 RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
ESR1 YWHAQ â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22329840
YWHAG FSCN2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
GRB2 PPP1R12A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 SYNPO â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 PPP1CB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 PDLIM7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 HSPA5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 IQGAP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 SPECC1L â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
VAV1 GRB2 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
HSPA5 RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSPA5 NFKBIA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
IQGAP1 RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
PPP1CB RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
PPP1R12A RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
SPECC1L RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
YWHAG SNW1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CFTR YWHAG â—¼   PHYSICAL_INTERACTION 810.0 0.81 STRING 36370105
ANLN SYNPO â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31586073 26496610
ANLN MYH9 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31586073 26496610
BMI1 SNW1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 34316702 24457600
CDK2 MYH9 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26496610 21319273
CFTR RCN1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26618866 17110338
ESR1 CTBP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 23403292 31527615
ESR1 SNW1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33731348 19934264
MDC1 CHEK2 â—¼   KO_DOWN_REGULATES ✅ - -0.83 0.82 PKG 28854368
SNW1 SPECC1L â—¼   PHYSICAL_INTERACTION 0.82 0.82 HuRI 32296183
ANLN MYO5C â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 31586073 26496610
BTF3 RPL15 â—¼   PHYSICAL_INTERACTION 830.0 0.83 STRING 36370105
HDAC6 CFTR â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 31501480 14675537 22069321
CFTR MYH9 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 26618866 29924966 22038833
ESR1 MYH9 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 25604459 19805454 21182205
ESR1 BTF3 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 18025262 31527615
GRB2 MYH9 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 20936779 24189400 12577067
MYH9 S100P â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 31837246 15171681
YWHAG YWHAH â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
GRB2 VAV1 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
GLIS2 ZRANB1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
ZNF219 CTBP1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
HDAC6 LPXN â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
PPP1CB PPP1R12A â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
APC CTBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15525529
WRN BMI1 â—¼   UP_REGULATES ✅ + 36.0 1.0 ACSN 11283614 12202749 12545156 15155580 15385537 16449207 17055429 17116323 17550342 17965729 18398454 18524993 18558713 18584027 18809224 19490890 20027199 20064462 20691907 20713526 20818389 21376743 21733352 2191300 21919891 22657828 22743550 23082994 23140366 23161013 23253856 23869868 24036544 24050180 24709898 9618481
CDK2 BMI1 â—¼   UP_REGULATES ✅ + 32.0 1.0 ACSN 11274345 11283614 12545156 14536078 15147722 15155580 15279786 17055429 17303408 17550342 17558397 17660363 17873522 18590585 18636226 20027199 20237412 20551172 20581311 20713526 20818389 21406394 21733352 2191300 21919891 22067385 23140366 23869868 25002027 28536364 7575488 9618481
CDK2 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 10428798 22431515 23390529 17570479 23770852
MDC1 CHEK2 â—¼   ENZYMATIC_REACTION ✅ 59.0 1.0 ACSN 11331603 11850621 11877377 12086603 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15242590 15279786 15375219 15377654 15459660 15485915 15798197 15964794 16163361 16332722 16531125 16713580 16805667 16818604 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17660363 18006705 18087292 18469862 18543256 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19282663 19342888 19622404 19686080 19772495 19793801 20051983 20723763 21376743 22743550 23847781 24050180 7575488 9407949 9488723
MDC1 CHEK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 12607004 18087292 17303408 20723763 18678890 19793801 9488723 12919958 24050180 15279786 7575488 16163361 18584027 18583988 22743550 16531125 23847781 18590585 15964794 21376743 12551934 12607003 17660363 15459660 19772495 11877377 18809224 11850621 9407949 18006705
GRB2 KSR1 â—¼   PHYSICAL_INTERACTION 53.0 1.0 ACSN 10086337 10567412 10811803 10843677 10982827 11023813 11034387 11062502 11274345 11385609 11447289 11777939 11907067 12040186 12175651 12419216 12640133 12782630 14585353 14724641 14764585 15169888 15173823 15536084 15547943 15567848 15574420 15735649 15863030 16102570 16227978 16488589 16582911 16887996 17178906 17395718 17496910 17613518 17673906 19289794 19449109 19541618 19565474 19568798 19615955 21102635 22435554 24027568 26552706 7510700 8551221 8929532 9510155
GRB2 KSR1 â—¼   SHARES_COMPLEX 53.0 1.0 ACSN 10086337 10567412 10811803 10843677 10982827 11023813 11034387 11062502 11274345 11385609 11447289 11777939 11907067 12040186 12175651 12419216 12640133 12782630 14585353 14724641 14764585 15169888 15173823 15536084 15547943 15567848 15574420 15735649 15863030 16102570 16227978 16488589 16582911 16887996 17178906 17395718 17496910 17613518 17673906 19289794 19449109 19541618 19565474 19568798 19615955 21102635 22435554 24027568 26552706 7510700 8551221 8929532 9510155
GRB2 VAV1 â—¼   ENZYMATIC_REACTION ✅ 57.0 1.0 ACSN 10077632 10086337 10426994 10567412 10646608 10679059 10714681 10811803 10849438 10898494 10982827 11080163 11447289 11526404 11698448 11754814 11777939 11777960 11907067 11994416 12094222 12165654 12175651 12186560 12616499 12626562 12640133 12740575 12885870 12917349 14764585 15169881 15536084 15567848 15574420 16339513 16582911 16713974 16887996 17070508 17100878 17496910 17673906 18490724 19449109 19909365 20189481 22513334 22786724 22952938 25355530 25539813 26552706 8189062 8226994 8551221 9438848
GRB2 KSR1 â—¼   ENZYMATIC_REACTION ✅ 53.0 1.0 ACSN 10086337 10567412 10811803 10843677 10982827 11023813 11034387 11062502 11274345 11385609 11447289 11777939 11907067 12040186 12175651 12419216 12640133 12782630 14585353 14724641 14764585 15169888 15173823 15536084 15547943 15567848 15574420 15735649 15863030 16102570 16227978 16488589 16582911 16887996 17178906 17395718 17496910 17613518 17673906 19289794 19449109 19541618 19565474 19568798 19615955 21102635 22435554 24027568 26552706 7510700 8551221 8929532 9510155
VAV1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 8900182 10207103 9013873 15558030 7651724 7809090 8621483 29997244 18692475 7478592 16713569 11406576 9209406 16339550
PPP1R12A MYH9 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 9354661 8662509 11331307 11942626
MYH9 PPP1CB â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 9354661 8662509 11331307 11942626
NUAK1 PPP1R12A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 17739896 24171924 22516431 18088087 19367720 19690332 20354225 19413330 18669648 29106388
YWHAG YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17085597 21827211 12426317 15324660 15071501 12657644
YWHAH YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21827211 12657644 12426317 15071501
MDC1 PDLIM7 â—¼   KO_UP_REGULATES ✅ + 1.2 1.2 PKG 28854368
WRN SPECC1L â—¼   KO_UP_REGULATES ✅ + 1.32 1.32 PKG 28854368
MDC1 MDC1 â—¼   KO_DOWN_REGULATES ✅ - -3.38 3.37 PKG 28854368
WRN WRN â—¼   KO_DOWN_REGULATES ✅ - -3.6 3.59 PKG 28854368