CRK
|
ASAP2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
YWHAE
|
CBL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
11697890
8005785
|
YWHAG
|
CBL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
11697890
8005785
|
CRTC2
|
YWHAG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5217174
15324660
|
DCAF7
|
YWHAG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5217174
15324660
|
YWHAE
|
HDAC5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
10737771
5212359
|
MAPK14
|
MAPT
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20626350
15632108
|
TP53
|
PRKAA1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
15866171
24874608
|
PRKACA
|
SIK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
22462548
27478041
|
SIK1
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19622832
|
SMAD7
|
TGFB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
10519551
19758997
|
YWHAH
|
STK11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
8329523
22575644
|
YWHAG
|
STK11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
8329523
22575644
|
TP53
|
STK11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
17108107
21317932
|
TP53
|
STK11
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23995788
21317932
|
YWHAZ
|
STK11
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
8329523
22575644
|
YWHAE
|
TAB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
TP53
|
YWHAE
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
18812399
8008642
|
YWHAB
|
YWHAG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
801.0
|
0.8
|
STRING
|
36370105
|
YWHAQ
|
CBL
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.81
|
0.81
|
mint
|
8005785
11697890
|
CBL
|
YWHAB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
819.0
|
0.81
|
STRING
|
36370105
|
1433Z
|
CRTC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
33961781
28514442
|
SIK1
|
PSF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
33961781
28514442
|
SIK1
|
SIK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
33961781
28514442
|
SIK1
|
SIK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
33961781
28514442
|
CRTC2
|
1433Z
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
16306228
28514442
33961781
|
SIK1
|
SLD5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
33961781
28514442
32707033
27592030
|
1433Z
|
SIK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
16306228
32707033
|
MAPT
|
YWHAB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
864.0
|
0.86
|
STRING
|
36370105
|
1433Z
|
SIK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
16306228
22588126
16968750
|
CBL
|
YWHAQ
|
â—¼ PHYSICAL_INTERACTION
|
|
|
878.0
|
0.87
|
STRING
|
36370105
|
MAPK14
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
879.0
|
0.87
|
STRING
|
36370105
|
YWHAE
|
YWHAG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
879.0
|
0.87
|
STRING
|
36370105
|
YWHAE
|
YWHAH
|
â—¼ PHYSICAL_INTERACTION
|
|
|
879.0
|
0.87
|
STRING
|
36370105
|
YWHAB
|
YWHAE
|
â—¼ PHYSICAL_INTERACTION
|
|
|
882.0
|
0.88
|
STRING
|
36370105
|
YWHAG
|
YWHAZ
|
â—¼ PHYSICAL_INTERACTION
|
|
|
882.0
|
0.88
|
STRING
|
36370105
|
YWHAG
|
YWHAH
|
â—¼ PHYSICAL_INTERACTION
|
|
|
882.0
|
0.88
|
STRING
|
36370105
|
YWHAB
|
YWHAH
|
â—¼ PHYSICAL_INTERACTION
|
|
|
883.0
|
0.88
|
STRING
|
36370105
|
YWHAH
|
YWHAZ
|
â—¼ PHYSICAL_INTERACTION
|
|
|
883.0
|
0.88
|
STRING
|
36370105
|
YWHAB
|
YWHAZ
|
â—¼ PHYSICAL_INTERACTION
|
|
|
884.0
|
0.88
|
STRING
|
36370105
|
HDAC5
|
YWHAE
|
â—¼ PHYSICAL_INTERACTION
|
|
|
889.0
|
0.88
|
STRING
|
36370105
|
SIK2
|
CRTC2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
15454081
22462548
29211348
|
HDAC5
|
YWHAQ
|
â—¼ PHYSICAL_INTERACTION
|
|
|
890.0
|
0.89
|
STRING
|
36370105
|
YWHAE
|
YWHAZ
|
â—¼ PHYSICAL_INTERACTION
|
|
|
899.0
|
0.89
|
STRING
|
36370105
|
TP53
|
CRTC3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
16980608
|
TP53
|
MAPK14
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
11437382
15132979
14570892
|
MAPK14
|
PRKACA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
15649893
|
SIK1
|
SMAD7
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
23331499
18725536
19030025
|
YWHAG
|
YWHAB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
17085597
15324660
|
YWHAB
|
YWHAG
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
17085597
15324660
|
MAPT
|
YWHAZ
|
â—¼ PHYSICAL_INTERACTION
|
|
|
908.0
|
0.9
|
STRING
|
36370105
|
YWHAZ
|
YWHAE
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.91
|
0.91
|
mint
|
20618440
7899808
|
CBL
|
1433Z
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.94
|
0.94
|
HIPPIE
|
11697890
9632690
20618440
9367879
|
1433Z
|
HDAC5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.95
|
0.95
|
HIPPIE
|
33961781
15161933
21081666
23752268
28514442
|
SLD5
|
PSF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
33961781
32296183
26344197
34195792
22939629
25416956
16189514
21705323
|
MAPT
|
PRKACA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
978.0
|
0.97
|
STRING
|
36370105
|
CBL
|
CRK
|
â—¼ PHYSICAL_INTERACTION
|
|
|
995.0
|
0.99
|
STRING
|
36370105
|
MAP3K7
|
TAB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
995.0
|
0.99
|
STRING
|
36370105
|
GINS2
|
GINS4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
CRK
|
CBL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
9.0
|
1.0
|
ACSN
|
11353765
15169881
15308668
16000375
16076871
18835194
19454690
20189481
22464172
|
CRK
|
CBL
|
â—¼ SHARES_COMPLEX
|
|
|
9.0
|
1.0
|
ACSN
|
11353765
15169881
15308668
16000375
16076871
18835194
19454690
20189481
22464172
|
CRK
|
CBL
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
60.0
|
1.0
|
Omnipath
|
8683103
16289966
8626543
8621483
9617486
16713569
9416834
8524328
10962563
8626404
9367879
8662998
12393469
11792427
15581361
9013636
15581362
9178909
9988765
18835194
8943292
20697350
9129019
19380743
25814554
9461587
|
SIK1
|
CRTC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
19244510
17525332
18669648
16817901
|
SIK2
|
CRTC2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
14.0
|
1.0
|
Omnipath
|
25484640
16308421
15454081
18669648
20577053
|
SIK3
|
CRTC2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
10.0
|
1.0
|
Omnipath
|
15454081
18669648
16306228
|
PRKAA1
|
CRTC2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
21892142
20577053
|
SIK1
|
CRTC2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
18.0
|
1.0
|
Omnipath
|
17145710
24529027
20551288
18348280
15454081
16306228
18669648
16817901
|
SIK1
|
CRTC3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
23033494
16817901
|
GINS4
|
GINS2
|
â—¼ SHARES_COMPLEX
|
|
|
11.0
|
1.0
|
ACSN
|
16531994
17102137
17116885
17296725
17417653
17582221
17652513
18451105
19158510
19223333
19793801
|
GINS4
|
GINS2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
11.0
|
1.0
|
ACSN
|
16531994
17102137
17116885
17296725
17417653
17582221
17652513
18451105
19158510
19223333
19793801
|
PRKACA
|
HDAC5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
22865920
20716686
|
PRKAA1
|
HDAC5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
27010499
18184930
21892142
|
TAB2
|
MAP3K7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
25.0
|
1.0
|
ACSN
|
10391247
11280761
11460167
11477091
12620219
14633987
14660645
15082531
15125833
16603398
16799562
17301840
17363905
18264787
18641653
19161412
20164171
21041997
21133840
21232017
22941947
23681101
24403530
24699077
24958845
|
TAB2
|
MAP3K7
|
â—¼ SHARES_COMPLEX
|
|
|
25.0
|
1.0
|
ACSN
|
10391247
11280761
11460167
11477091
12620219
14633987
14660645
15082531
15125833
16603398
16799562
17301840
17363905
18264787
18641653
19161412
20164171
21041997
21133840
21232017
22941947
23681101
24403530
24699077
24958845
|
SMAD7
|
MAP3K7
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
12589052
|
TAB2
|
MAP3K7
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
112.0
|
1.0
|
Omnipath
|
17145710
11477091
17301840
18180283
10838074
24912525
16251197
10882101
19556242
15125833
19955178
31250519
36130827
17363905
17158449
11259596
19026643
24699077
14670075
18641653
24061540
24403530
23331499
22158122
12372426
21903422
27426733
21071413
23180781
14743216
18021073
21133840
20200282
26432169
21232017
18264787
20194509
10391247
18988627
22081109
8638164
16799562
11809792
19232515
12620219
14633987
19161412
20538596
22941947
23681101
20932475
15590691
12609980
16845370
27468689
12242293
11280761
15082531
26192618
14660645
24958845
17172402
15327770
25642820
22167179
20164171
16603398
17384642
11460167
21041997
|
MAP3K7
|
PRKAA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
16054096
16054095
15509864
19197243
17244528
20615388
18692468
15980064
|
MAP3K7
|
MAPK14
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
12589052
17965022
15692051
17947236
|
MAPK14
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
57.0
|
1.0
|
Omnipath
|
21675959
26247731
20213747
17535811
20506250
15657900
9315650
15642743
19413330
11283254
22975381
10581258
16083285
1088347
21614932
16393692
10884347
21050851
16552184
10747897
15187187
17906639
25789565
15140942
11258706
24818748
19436832
10781582
10212189
17172861
10348343
11078726
11274345
|
PRKACA
|
MAPT
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
77.0
|
1.0
|
Omnipath
|
9614189
9832145
19562805
12387894
9546672
19413330
1730702
7706316
9353289
20068231
16923168
21215781
8999860
9565682
11181841
10737616
7566346
12435421
17287340
9771888
19651622
9735171
11104762
12226093
16000144
8163474
26840030
6412713
9199504
10090741
11311121
2387894
|
PRKAA1
|
STK11
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
6.0
|
1.0
|
Reactome
|
14511394
15579580
8779952
14985505
14614828
11018120
|
PRKACA
|
PRKAA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
12764152
17023420
27784766
|
STK11
|
PRKAA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
64.0
|
1.0
|
Omnipath
|
16434556
25792737
14985505
14976552
20489196
21062936
20656472
20616029
17255104
16041368
25696921
21399626
12391032
20160076
17244528
15980064
17054914
22517326
14532170
21918180
28694351
18693249
26771234
20801214
16600998
18195011
28723898
16912160
22039048
26068970
14614828
19884317
25679763
22575644
19197243
27864418
30022161
25683918
18303014
17287464
15327994
12764152
16054095
15509864
26506235
14511394
27181208
28625738
25874865
8910387
17276402
26247630
21680840
19414597
23418352
24289924
15383373
|
PRKAA1
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
28797070
15866171
|
PRKACA
|
STK11
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
11853558
17482548
11297520
17482549
10642527
|
PRKACA
|
YWHAZ
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
11.0
|
1.0
|
Omnipath
|
29109150
11956222
12861023
16376338
19451227
|
STK11
|
SIK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
18946175
18348280
14976552
|
STK11
|
SIK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
14976552
23322770
|
STK11
|
SIK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
19369195
22588126
14976552
|
TGFB1
|
SMAD7
|
â—¼ UP_REGULATES
|
✅
|
+
|
27.0
|
1.0
|
ACSN
|
11133108
11708773
12490555
14557817
15111329
15181457
15252039
15548370
16474430
16607286
16716598
17615296
17934056
18403754
19010789
19109155
19920116
20519943
20644162
21041997
21278795
21900405
21909923
22703233
7594497
9157999
9335507
|
SMAD7
|
TGFB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
19.0
|
1.0
|
Omnipath
|
10887185
15855807
9886263
20631490
22656308
19214138
23633623
14600158
10753944
11912247
11385614
11180003
17928287
19010789
22496417
22841502
17074765
15496141
11448947
|
TGFB1
|
SMAD7
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
19010789
14718519
16474430
17934056
20519943
9335507
21900405
11133108
14557817
15548370
19920116
|
SMAD7
|
TAB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
23331499
17384642
|
STK11
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
20815019
11430832
17108107
16713569
|
TP53
|
TGFB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
12732139
10618379
22264233
23706820
14514686
8183578
14761612
16138117
18593586
23063463
8119773
|
YWHAE
|
YWHAB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
20936779
17085597
12507503
24255178
17979178
|
YWHAB
|
YWHAQ
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
17085597
12657644
12426317
15071501
|
YWHAB
|
YWHAE
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
20936779
17085597
12507503
24255178
17979178
|
YWHAH
|
YWHAE
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
20936779
12507503
7615088
26496610
17979178
|
YWHAZ
|
YWHAE
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
21988832
20936779
20618440
26496610
16376338
17979178
19766566
|
YWHAG
|
YWHAE
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
21988832
20936779
17085597
12507503
17979178
|
YWHAE
|
YWHAQ
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
21988832
20936779
20618440
17085597
21827211
12426317
15071501
12657644
17979178
|
YWHAE
|
YWHAG
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
21988832
20936779
17085597
12507503
17979178
|
YWHAE
|
YWHAZ
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
21988832
20936779
20618440
26496610
16376338
17979178
19766566
|
YWHAE
|
YWHAH
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
20936779
12507503
7615088
26496610
17979178
|
YWHAG
|
YWHAQ
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
17085597
21827211
12426317
15324660
15071501
12657644
|
YWHAH
|
YWHAQ
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
21827211
12657644
12426317
15071501
|
YWHAZ
|
YWHAQ
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
21827211
12657644
12426317
15071501
|