Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
CEBPZ PROX1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
PROX1 HDAC3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18948102 6787391
PROX1 SUMO1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18948102 6787391
SOX18 PROX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20360386 18931657
PROX1 NR5A2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19264593
PROX1 KDR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17047989 19210544
PROX1 GFI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18652815
PROX1 ATOH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18652815
SOX2 ATOH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22340499 22292066
SOX2 ATOH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15846349
NOTCH1 ATOH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16283144
CTBP2 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19798104 23255392
HNF4A CEACAM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8055923
TP53 CEBPZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12534345 5216050
PAX6 CRYBB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9710641 14707122
SUMO1 CTBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12769861 12679040
PPARG CYP7A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath
HIF1A ESRRA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0711677105 18509053
ESRRG ESRRA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17157980 15821111
PPARG ESRRA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20519122 15821111
HDAC3 TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16847267 0510834103
NOTCH1 HIF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18427106 0802047105
HIF1A NOTCH1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18427106 0802047105
NR5A2 HNF4A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12069850 10799577
NR2F2 HNF4A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11981036 18474611
PPARG IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19160541 15187132
IRF4 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21816905 20674401
MAZ PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17902047 19061500
NOTCH1 SOX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17537801
NR2F2 PCK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14739255 11399762
PPARG RORC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9702045 19737866
SUMO1 RORA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19041634
TP53 SMAD3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21900401
TP53 SUMO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11420669 21187340
EP300 CHD4 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 32699137 30110629 15189737 26546801
ERR3 PROX1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 15604093
CTBP1 EP300 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 15834423 21102443 16122695 35016035
EPAS1 EP300 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 23275444 22807441 15261140 25689462
EPAS1 SUMO1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 20026589 20661221
SOX2 SUMO1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25416956 17097055
CTBP1 CHD4 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 28514442 31041561 24981860
PROX1 HNF4A â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 16488887 15604093
SOX2 HDAC3 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 35140242 23667531 21532573
HDAC3 HIF1A â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 11641274 17273746
HIF1A TP53 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
FLT4 KDR â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
SUMO1 TP53 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
EP300 PPARG â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
PROX1 NR5A2 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 15205472 16488887
EP300 RORA â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 16713569 9862959
HDAC3 PPARD â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11867749 12943985
CTBP1 CTBP2 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
CTBP2 CTBP1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 28514442 27107012 33961781 26344197 26496610 35016035 31041561 30585266 26186194 24722188 21988832 16713569 9858600 25416956 28947780 16189514
EP300 PAX6 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10506141 35140242
CDKN2A TP53 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
PROX1 CRYBB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19023449 18385074 14707122
PROX1 CYP7A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15205472 16488887 23626788
PROX1 FGFR3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19706680 18815287 16291864
PROX1 HNF4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16488887 15604093
PAX6 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20053773 11584062 17157287
HOXD8 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19340300
SUMO1 CTBP1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 20176810 20098713 12679040
EP300 HNF1A â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 35140242 15598887 11978637
HIF1A RORA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15270719 14742449
HIF1A PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18461556 19490906 11879638
NOTCH1 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18722525 23331499 16256737
NR2F2 HNF1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10331424 8622679 9111350
SUMO1 NR5A1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15192092 15192080 21467194
NR5A1 NR5A2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23471216 23340581 23537609
NR5A2 SUMO1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 20159957 15923626 19692572
PPARD PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20097210 10991946 20176998
PPARG TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16887883 14960510
HNF4A HIF1A â—¼   PHYSICAL_INTERACTION 0.91 0.91 HIPPIE 12097158 14741200
EP300 TP53 â—¼   POLYUBIQUITINATION ✅ - 0.91 0.91 Signor 12690203
EP300 SMAD3 â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
SUMO1 HIF1A â—¼   PHYSICAL_INTERACTION 0.95 0.95 HIPPIE 20661221 24434214 20026589 17938407 15465032 15876874
HIF1A EP300 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 18268343 15154850 12914934 19074848 25192544 22789427 20829524 21148070 17502379 26826385 22075993 16543236 19680224 20603618 19589782 11063749 23618863 26135796 27808477 22219185 15155277 11823643 17906695 19666581 21187066 16189267 8917528 23746844 19940151 19071119 26944191 15261140 24421387 20000859 12778114 14691445 12042299 22684029 12588875 17382325 23966271 15342390 22735262 27320910 26751287 24821806 23448368 11959990 15280364 11940656 19696166 20620956 16081065 22908229 18047470 16847340 22807441 23880760
TP53 EP300 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 16611888 6599495
EP300 TP53 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EP300 HIF1A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PROX1 FLT4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19901262 19210544 18815287 19706680 21807940
AKT2 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17964260 16926151
EP300 CDKN2A â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 32284348 19273602 32601262 10821856 28985506 33043019 31597407
TP53 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 16103197 22467867 18555006 8631601 11402335 19649205 22020338 21164364 17265068 16764954 15775976 22056554 18275833 21483786 10348346 19216023 12384561 12091906 19901969 11360201 15205322 11818069 21892281 10980602 11739748 11559812 24672805 10097151 17907153 19244234 15361884 10652576 9436028 21447739 20569441 21555589 21637567 10816133 9774662 19240179
CDKN2A TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 15856024 15989956 9724636 19960022 12740913 17158541 12640129 19590512
HNF1A CYP7A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15933209 10403849
NR2F2 CYP7A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10627496 9092518 10403849 9799805 23458092
HNF4A CYP7A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 23626788 23038264 17920062 10627496 17603092 21963511 15933209 9013589 16488887 16492670 9799805 15331348 17660447 16049268 11402042 17636037 15322103 16323215
IFNG EP300 â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 10485906 11489965 11579131 11777960 11870632 11964313 12413632 12818165 14607900 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 1825141 18272812 19833085 20038811 20819927 21149606 21411734 24658051 26755705 2965306 6425450 9834059 9864217
EP300 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 9843571 11134049 12743039 15133024 15824515 15623506 16876108 21567395 16109717 17074756 20564330 10497242 15588252 17469184 15345715 11058129 10575014 16862174
EP300 STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 21988832 14726487 15509516 9989503 9773981 26504087
EP300 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 137.0 1.0 Omnipath 11907332 25545885 21187340 10706102 16438982 10490106 19339993 15542844 23010591 11433299 19608861 17438265 17906639 16024799 9194564 20234175 23402884 12162806 26229107 16959611 15186775 9744860 11070080 17977830 17189186 22266186 20228809 15664194 19805293 25753752 11804596 26625199 27818144 10648616 16928824 9288740 10942770 12724314 23148227 23728348 15965232 19218448 16678111 16782091 20094059 14612423 24821727 10518217 16713569 9891054 25288747 17452980 14759370 19788416 25156994 18931695 22074660 23880760 15337767 15509808 26302407 22731250 18391200 16543236 19234109 21471221 23307557 25867071 12690203 15558054 18612383 23870121 18243116 19217391 22013068 16537920 16611888 18485870 9194565 12660246 9809062 23796514 11359905 12501250 15295102 19407812 25651062 23329847 16135789
EP300 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 75.0 1.0 Omnipath 24821806 12573436 17145710 16847340 12588875 19589782 11940656 25192544 11959990 18519678 23448368 22219185 11823643 12042299 15342390 23746844 19071119 19680224 27808477 15154850 19696166 8917528 17906695 18268343 22735262 21148070 15261140 19940151 23880760 22807441 35430356 14691445 12914934 20000859 12778114 26751287 16081065 22789427 16543236 24421387 17382325 17502379 22684029 21187066 19074848 23618863 23966271 20603618
HIF1A EPAS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20513003 18174278 16924414 19030186
KDR FLT4 â—¼   PHYSICAL_INTERACTION 34.0 1.0 ACSN 10022831 11166270 11960372 12629515 13678960 15099563 15111329 15308668 15501236 15520864 15573129 16000375 16002046 16076871 16530705 16572188 17086423 17883421 18835194 19414323 19454690 21372296 22064427 22461508 22464172 23390297 24217602 24346288 25922287 26201938 8837607 9157999 9570538 9753319
KDR FLT4 â—¼   SHARES_COMPLEX 34.0 1.0 ACSN 10022831 11166270 11960372 12629515 13678960 15099563 15111329 15308668 15501236 15520864 15573129 16000375 16002046 16076871 16530705 16572188 17086423 17883421 18835194 19414323 19454690 21372296 22064427 22461508 22464172 23390297 24217602 24346288 25922287 26201938 8837607 9157999 9570538 9753319
TP53 GHRHR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10529175 24297337 11852084 24737129
HDAC3 PPARG â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 11399519 11875494 15644117 16127449 17260466 17681149 17689680 21234400 23390297 6357187 8871614
HDAC3 PPARG â—¼   SHARES_COMPLEX 11.0 1.0 ACSN 11399519 11875494 15644117 16127449 17260466 17681149 17689680 21234400 23390297 6357187 8871614
HDAC3 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17015477 16189514 12479814
IFNG HIF1A â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 10485906 11489965 11579131 11777960 11870632 11964313 12413632 12818165 14607900 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 1825141 18272812 19833085 20038811 20819927 21149606 21411734 24658051 26755705 2965306 6425450 9834059 9864217
HIF1A TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 12542982 17390008 9537326 15780936 11696352 10469629 17236590 20706634 15629713 11007955
TP53 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 9537326 16713569 12124396 15629713 16882692
HNF4A HNF1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 8367288 9111350 9792724 8674436 11717395 9313764 9837989 9204893 9232592 1734282 20850486 8735941 11145965 11085951 10331424 8808405 12601360 16670373
TP53 HNF4A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11818510 16895524
SMAD3 IFNG â—¼   DOWN_REGULATES ✅ - 25.0 1.0 ACSN 10925299 11074002 11279127 11399519 11792802 11875494 12193690 12702545 12809600 15265520 15644117 16127449 16179589 16713975 17260466 17689680 18768831 21042762 21614932 22331441 23390297 6357187 8515656 8871614 9389648
STAT5A IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12759422 7875295 7796811 15528362 9831114
SMAD3 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 23331499 16713569 14638857 18988627
NR2F2 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 23331499 10098492 20592862
TP53 OGG1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16293709
PAX6 SOX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19666824 17825048 11358870
SMAD3 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21836474 21926264 12457461 12524424
TP53 KDR â—¼   KO_UP_REGULATES ✅ + 1.12 1.12 PKG 28854368
TP53 NOTCH1 â—¼   KO_DOWN_REGULATES ✅ - -1.46 1.45 PKG 28854368