Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
GADD45G GDF9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
PCNA EEF1A1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7995081 20849852
PCNA CDKN1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
CREB1 PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7721872 12658356
TP53 PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7915517
CEP126 LUC7L2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
PTN LUC7L2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
KAT5 CEP126 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
CEP126 LRIF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
CEP126 KAT5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
CEP126 GADD45G â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
KAT5 AR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10364196 5211544
AR TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19481544 7103716
AR GADD45GIP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17885209 24103312
AR CEBPD â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24810056 20610535
AR IL18 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15178407 20610535
AR RARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12069693 20610535
AR VDR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15805579 16425262
AR SMAD1 â—¼   COLOCALIZATION 2.0 0.8 intact 5219486 17183365
EZH2 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24457600 23239736
RXRA AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 15650026
AR RXRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 15650026
AR CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10076995
TP53 ATF3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
CEBPB ATF3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16989641
NFKB1 ATF3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24100018
ATF3 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22046379 18644986
KLF5 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19628677 21383775
NR2E1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22194602 21957244
CDKN1A TP53 â—¼   COLOCALIZATION 2.0 0.8 intact 16616141 5218511
PPARG CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15041706
CEBPB GADD45G â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11012671
CEBPB GADD45A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16418324 11012671
CEBPB CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12773552
CEBPD GADD45G â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11012671
SGK1 CREB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15733869 5217559
CREB1 SGK1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 15733869 5217559
RELA CRIP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1101747108 21540330
DCTN2 GADD45A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
TP53 EEF1A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
MED31 EEF1G â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
GADD45G EEF1G â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
SKIL EEF1G â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
ESR1 SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21920899 23658738
ESR1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16144913
TP53 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10766163 16713569
ESR1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16144913
GADD45GIP1 GADD45A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216338 12716909
KAT5 GADD45G â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
MED31 GADD45G â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
PIAS4 GADD45G â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
LUC7L GADD45G â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
PTPRK GADD45G â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
LRIF1 GADD45G â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
RBM48 GADD45G â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
GADD45GIP1 GADD45G â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216338 12716909
GADD45G PTN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
GADD45G PLEKHM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
GADD45G MED31 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
GADD45G MAP3K4 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 11371360 24104473
SMAD1 GADD45G â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22219353
SMAD5 GADD45G â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22219353
NFKB1 GADD45G â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23681230
RELA GADD45G â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23681230
JAK2 IL12A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22306691 12829785
REL IL12A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16166378
IL12RB1 JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 10198225
IL18R1 IL18RAP â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
LRIF1 KAT5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
TSNAX KAT5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SIRT1 KAT5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20100829
LRIF1 PIAS4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
RELA PIAS4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0701877104 17606919
PIAS4 SKIL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
PIAS4 PTN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
RELA PPARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10542237 16189514
RELA PPARD â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14708613
RELA REL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5211837 10498867
RELA STAT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25040843
SKIL SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12419246 12426322
SMAD1 SMAD5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
TP53 VDR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
CREB1 TP53 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
EEF1A1 EEF1G â—¼   PHYSICAL_INTERACTION 814.0 0.81 STRING 36370105
CEBPB ATF3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 20110283 20102225
RARA KLF5 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 16224062 18466769 21383775 16102021 12101409
PPARG RARA â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 32296183 32929351
ESR1 ACTN1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 23403292 31527615 19805454 21182205
KAT5 STAT3 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 12551922 16713569
PIAS4 SMAD1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 12904571 16189514 15231748
ATF3 TP53 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
ESR1 TP53 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
RELA STAT3 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
PCNA CCNB1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 28514442 8101826 33961781 7903056
ESR1 EZH2 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 31527615 17502350
ESR1 RXRA â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 9121466 23403292 9717844
CEBPB ESR1 â—¼   PHYSICAL_INTERACTION 849.0 0.84 STRING 36370105
MAP2K3 MAP3K4 â—¼   PHYSICAL_INTERACTION 849.0 0.84 STRING 36370105
KLF5 NFKB1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 14573617 16713569 16102021
ESR1 STAT3 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 23874500 11429412
ESR1 RARA â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 25604459 25303530 9717844
ARPC5L GADD45G â—¼   PHYSICAL_INTERACTION 0.86 0.86 HuRI 32296183
GADD45G RASSF10 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HuRI 32296183
CDKN1A GADD45A â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
IKBKG RELA â—¼   PHOSPHORYLATION ✅ + 0.86 0.86 Signor 15489227
CEBPB CEBPD â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 1840554 20102225
KAT5 TP53 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
MAP2K6 MAP3K4 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
CDKN1A STAT3 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
CDK1 EZH2 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
JAK2 STAT3 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
PPARA RXRA â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
SIRT1 TP53 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
PPARD RXRA â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 15888456 34081964 19756148 22205725 15604093
REL RELA â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
DDIT4L PPIL1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
CCNB1 CDKN1A â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
GADD45G TSNAX â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
CDKN1A GDF9 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
PPARG PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17389773 14764597 19673929
IL12B IL12RB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18389480 7638186 7528775
IL12RB1 IL12RB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18389480 7638186 7528775
IL12A IL12RB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18389480 7638186 7528775
GADD45G LUC7L2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MIDN GADD45A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MIDN GADD45G â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
AR IL12A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 26939703 23941877 20610535
RELA AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16713569 8798655
GADD45G CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10973963 16713569
EEF1A1 CDKN1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MED31 CDKN1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CDKN1A TRMT2A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CDKN1A PDE4DIP â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CDKN1A LRIF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CDKN1A DDAH2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CDKN1A RBM48 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
SIRT1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 23474493 15130752 21719763
SMAD1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19819988 11786386
CREB1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25379405 14520699 21295542
KAT5 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17671089 20351180 16601686
CEBPB IL12B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11509602 24012417 11279072
CRIP2 GADD45G â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
DDAH2 GADD45G â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
GADD45A EEF1A1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
EEF1A1 GADD45G â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
TP53 EEF1A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23799104 9269753 18431400
EEF1G GADD45A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
GADD45G EIF3G â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
STAT3 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21546410
ESR1 VDR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15664452 17556531 12710998
RXRA ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 9841885 9717844
ESR1 RXRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 9841885 9717844
EZH2 GADD45G â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
EZH2 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20132185 21546904 24006445
PTN GADD45A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
GADD45A TP53 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
ZNF579 GADD45G â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
PDE4DIP GADD45G â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
RDH13 GADD45G â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
SMARCB1 GADD45G â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
TRMT2A GADD45G â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
PDIA4 GADD45G â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
GADD45G PHAX â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
TP53 HP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16199185 8857671 22243239
IKBKG RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15489227
IL12B IL12A â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 7527811 10899108 10779781
IL12A IL12RB1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18389480 7638186 7528775
IL12A TYK2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18389480 7638186 7528775
JAK2 IL12B â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18389480 7638186 7528775
IL12B TYK2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18389480 7638186 7528775
IL12B IL12RB1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18389480 7638186 7528775
NFKB1 IL18 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10227974 17399992 15963597
RELA IL18 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10227974 17399992 15963597
NFKB1 STAT3 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 25241761 12057007 16713569
RXRA PPARA â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 15888456 12562861 7760852 34081964 10195690 22205725 23711995 16189514
RELA PPARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20054868 10542237
PPARD PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20097210 10991946 20176998
SIRT1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15850715 21633182
SMAD1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23071089 12589053 16580992
PPARG TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16887883 14960510
VDR RXRA â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 10733574 15604093 12847098 17500032 17786964 12796488 15829977 15647825 20153625 11075811 15888456 9632709 21988832 27728806 15890193 10224118 16750418 16357103 11514567 20564192 14726489 15805579 26329759 11149488 11124027 21478865 10037600
STAT3 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16107692 23874455 20043094
TP53 VDR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16462763 16651407 18431400
GADD45A PCNA â—¼   PHYSICAL_INTERACTION 903.0 0.9 STRING 36370105
DDIT4L GADD45G â—¼   PHYSICAL_INTERACTION 0.9 0.9 HuRI 32296183
CDK1 CDKN1A â—¼   PHYSICAL_INTERACTION 909.0 0.9 STRING 36370105
NFKB1 REL â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
GADD45G RWDD2B â—¼   PHYSICAL_INTERACTION 0.92 0.92 HuRI 32296183
CDKN1A PCNA â—¼   PHYSICAL_INTERACTION 0.94 0.94 HuRI 32296183
RXRA RARA â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 5212283 10698945
IL12A IL12B â—¼   PHYSICAL_INTERACTION 951.0 0.95 STRING 36370105
CDKN1A TP53 â—¼   PHYSICAL_INTERACTION 968.0 0.96 STRING 36370105
CCNB2 CDK1 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
PPARG RXRA â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
RXRA VDR â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
RARA RXRA â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
CCNB1 CDK1 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
NFKB1 RELA â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
PCNA GADD45A â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 10779360 11756412 12124778 14624239 14726013 15703371 15917306 16697054 17599061 19004803 19652693 1974050 19847258 20457011 22021614 22615860 23414611 23485469
PCNA GADD45A â—¼   REGULATES ✅ 18.0 1.0 ACSN 10779360 11756412 12124778 14624239 14726013 15703371 15917306 16697054 17599061 19004803 19652693 1974050 19847258 20457011 22021614 22615860 23414611 23485469
TP53 PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 10321841 7915517 15358233 12217864 10516009 1705714 8570655 16980608 9707425 15950182 19789303 11313928 1356162 12384701 9858527 12947108 23390122 8524244 9651310 1352831 7909518 11032828 10910968 12485898 10618724
GADD45A PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 7784094 23485469 10973963 7973727 10828065 16189514 20460379 7478510
GADD45G PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10828065 16713569 10455148 11022036
CDKN1A PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 67.0 1.0 Omnipath 23443559 25411249 20606006 8868473 15576034 16474839 25416956 20605778 16510448 18703516 23139781 11302688 11254741 26272819 16616141 21988832 11313979 7780738 17588519 12964161 25502805 10022118 8861913 16189514 26496610 16082198 8861969 17129767 18263614 26186194 22383522 22911014 7915843 7911228 27107012 23223023 17115032 32296183 19895794 18794347 19704162 10873631 9546435 8662825 31515488 21415862 9545252 11350925 12930846
TYK2 IL12RB2 â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 10807786 11867689 12244147 12372421 14610620 15546391 19833085 20406969 21042762 21115385 22077060 24091328 24204259 27216177 7543512 8683106 8700208 9834059
JAK2 IL12RB2 â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 10807786 11867689 12244147 12372421 14610620 15546391 19833085 20406969 21042762 21115385 22077060 24091328 24204259 27216177 7543512 8683106 8700208 9834059
IL12RB2 IL12RB1 â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 10807786 11867689 12244147 12372421 14610620 15546391 19833085 20406969 21042762 21115385 22077060 24091328 24204259 27216177 7543512 8683106 8700208 9834059
JAK2 IL12RB2 â—¼   SHARES_COMPLEX 18.0 1.0 ACSN 10807786 11867689 12244147 12372421 14610620 15546391 19833085 20406969 21042762 21115385 22077060 24091328 24204259 27216177 7543512 8683106 8700208 9834059
TYK2 IL12RB2 â—¼   SHARES_COMPLEX 18.0 1.0 ACSN 10807786 11867689 12244147 12372421 14610620 15546391 19833085 20406969 21042762 21115385 22077060 24091328 24204259 27216177 7543512 8683106 8700208 9834059
IL12RB2 IL12RB1 â—¼   SHARES_COMPLEX 18.0 1.0 ACSN 10807786 11867689 12244147 12372421 14610620 15546391 19833085 20406969 21042762 21115385 22077060 24091328 24204259 27216177 7543512 8683106 8700208 9834059
IL12B IL12RB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11086056 8943050 1108605611940480 11940489
IL12A IL12RB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11086056 943050 8943050
NFKB1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 14576180 15517885 20159994 12165860 16619263
RELA AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 24466341 16619263 14576180 15517885 14715080
ESR1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8299561 11000528 22391641
TP53 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17202838 18084622 18945670 11504717
AR SGK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19318566 21809344 20610535 17932503
AR CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 16281084 10076995 11606392 10606230 20610535 10809237
AR KLF5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19460858 20610535
KAT5 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11591700 10364196 19150978 11994312 16713569
CDK1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 26573794 12569365 22275373 25704883 17043241 23321516 9725910 24480624 21799006 24424504 28062857 21820033 25950519 28415597 27450452 25691442 21782001
PIAS4 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 16713569 14981544 11439351
AR ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 12389206 11032808 16713569 11000528 18988627
TP53 ATF3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12386811 12372430 17108111 21927023 21394211
ATF3 IL12B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17785797 16688168 24317040 26416280
TP53 ATF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15933712 18431400 11792711 16169070 16713569
TP53 CCNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 12874009 14627709 10051609 11313928 17942917 11892838 15710382 20395210 19470724 12379461 11071927 11522645 15737644 11162602
CDK1 CCNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 17145710 23799914 34224728 20117088 16784539 24358021 24508230 19470789 10973963 17283331 20228808 18347064 11242082 12397081 10362260 24582498 15582998 20367638 1833185 12447691 9001210 2570636 24101512 23543736 11331587 12524548 22726437 27626412
CDK1 GADD45A â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 12124778 14551205 14614141 15242590 15279786 15375219 15377654 15485915 15917306 16713580 16818604 17303408 17660363 18414028 18543256 18590585 18995830 19004803 19652693 19686080 23485469 7575488
CDK1 GADD45A â—¼   SHARES_COMPLEX 22.0 1.0 ACSN 12124778 14551205 14614141 15242590 15279786 15375219 15377654 15485915 15917306 16713580 16818604 17303408 17660363 18414028 18543256 18590585 18995830 19004803 19652693 19686080 23485469 7575488
TP53 CDK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 10825186 11593387 12874009 19472317 10514438 11313928 16807237 8270002 17942917 9275177 20395210 11032828 19861536 12889596 19067706
GADD45A CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 18942077 10362260 10973963 12124778 16189514
CDKN1A CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 9467962 26186194 21308745 15340381 23602568 23543736 24218572 17679094 15077146 26496610 12973835
CDK1 RXRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10383391 17570479 12032153
CDK1 KAT5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 21658600 12468530 16103124 17570479 26829474 18669648
CDK1 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 28.0 1.0 Omnipath 25841987 34381492 25691891 27941792 27653691 23549878 25800736 22187039 23241245 25038756 25334066 22964433 27716745 20935635 21131960 29576612 33593912 21123648 23438432 21659531 26552009
CDK1 SIRT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19107194 17570479 24011073 28756945
CDK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 24173284 12767922 1584757 20661218 26029996 2141171 9467949 17570479 20808790 7862459 11327730 11078726 27726420 8357826 16713569 2156209
RELA CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18954936 22305266 23037503 18269916
STAT3 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23178160 19372587 15286705 18320073 15063116 16923815 9694869 22328012 12438313 11773079 20654581 10023678 19329556 21184768 11114718
CEBPB CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10982390 15466360 15041706
VDR CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17680631 23087083 16434701 21088000
ESR1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 15557281 16628468 20696891 16847062 12151347 11517191 15378598 11274368 16469747 17681750 20301197 22787161 23349794
TP53 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 389.0 1.0 Omnipath 9349504 22270849 8749722 21242964 22290440 23874636 23349794 23650552 17280505 16288208 19882681 22948151 8641969 18840648 7777546 9360984 9707425 14614448 15586362 12889596 10597242 18719376 17938176 16343438 9916993 12806965 15024021 10037739 19394332 19749793 22480684 15136035 19501055 22732402 15988033 17307334 18272192 23665236 20331637 10435630 12239594 14743206 24599959 9714336 9652736 19954840 12392301 15339933 9154806 19383287 21295542 16894028 23187802 15248906 14522900 18483411 16261158 11892838 20190809 17167174 18615633 15790310 17916908 19472317 12717415 19789303 16317118 7696178 24584189 22989750 18573881 22532570 9288775 16103882 11890931 17646389 17344317 10753197 8557703 15872011 24356969 11278953 22279545 12902982 9920903 18644983 21524151 16540664 10935506 16537920 19843844 9535786 17878219 9405685 10749849 18656471 11021966 19723072 16778363 18628250 16557594 9614553 21791610 10072388 12203124 12420214 12640112 16601686 20531308 15741235 17317670 18446786 18505818 9224526 17569660 21900401 14517211 12934105 22713239 11313928 15492238 17509529 15985438 14722112 18755897 15489892 23759594 7624148 17786325 9223430 24074410 9525742 11395510 21317932 11444825 18645021 15856024 10559267 18593586 16970927 12665570 10101800 23017582 20696891 9268733 22001409 24821728 23146670 22427654 12573582 19118657 11973611 24096481 20797428 17685229 23066038 10029406 12681065 12433990 18769160 15208672 11152513 8547219 15851483 23474493 24384472 11175333 17158927 23100276 17762884 18951877 12045203 15051477 16107883 18521083 23159636 8603071 20814747 15082782 11375890 21084835 10348346 22244155 21325288 12379483 14580351 17592775 8910340 15566940 12173040 12007564 12609999 8878553 12080472 12384701 22266868 17404570 23329847 7478511 15067082 15007388 16458891 9268365 15728246 17224908 10094833 15897882 18059034 11739748 7624134 17146435 18690848 21528307 21546904 18208621 18172861 17977830 17721438 20817677 22894933 18225552 21642427 11162600 9183012 8647846 10660101 21858218 22514644 18451802 11384995 20673369 7774811 20187950 16230382 17339230 12168779 19630958 8242752 9895308 21606339 11748232 16410722 22611192 16061648 15009091 22503977 8799837 15660129 20473858 20448457 16488074 14612423 21903579 11668476 11313463 17101782 19067706 17121856 10792001 16341121 12925527 7566157 22190353 12782287 9233781 15509808 21245169 17145718 24134839 10498892 18094076 14635196 23208500 20843368 10327058 21969549 9440695 10625687 20885946 12851404 19846554 10910098 14614455 18419600 21552844 24835508 21541551 9472102 11922774 19244234 17903248 9216067 18193090 10566557 18757425 11429705 19608464 8632901 8691637 15184659 12716906 15259070 24559687 7970699 15738655 9588214 16574813 15302882 12560513 16131836 16778203 10522058 11032828 9816111 9108440 15860260 17108107 25024194 9582019 22266186 20036872 9926942 15710329 19243472 17997002 19435914 21093383 23149933 11162506 17678435 11895854 8616838 12748190 17610896 18269916 22086179 21557991 17942917 24821727 11557753 16204065 18645003 24205274 9816061 12226108 24379401 15539944 7753560 15371422 10799578 10777217 16434701 17996705 21957244 9191059 9519881 9207798 24289924 21733196 15496412 20124454 20153576 22172947 10321740 21715977 22253232 8816885 24189165 15882981 8752276 20511722 11514734 20962589 12869419 16733561 19713748 16931520 10499591 16581545 19738071
RARA CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10356361 24821728 21383775
PPARG CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 19551868 19103521 19208833 16985067 18509005 15041706 15345676 16091736
EZH2 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 21572997 21546904 24074410 21629038 22956625
TP53 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 19922265 12897156 19597488 16616141 28433629 20066118 20457558 19749794 6396087 21163364 17371838 21900206 21340684 25241761 12897801 12748190 20182602 11896572
CDKN1A STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 25241761 16189514 10764767
STAT3 CEBPB â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
CEBPD CEBPB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 7646815 18703634 7910803 11559710 18092000 1741402
ESR1 CEBPB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19652226 18414489
CEBPB PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 22473998 23934183 7557387 12524424 16431920 22610404 15110775 18694725 17242167 16054042 15158467 9950217 10862621 20829347
CEBPB HP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 14661730 11027530 11316061 21917825 11331273 16172914 10445852 20155810
CEBPB TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19135161 23564453 19075931 24333671
CEBPB STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11134330 18266962
STAT3 CEBPD â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10867011 17471507 24011072 15389878 15486993 9163525 25787076 15930175 9528783 16293640
CEBPD HP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 14661730 11027530 15694370 11559710 17910034
CREB1 RELA â—¼   PHYSICAL_INTERACTION 21.0 1.0 ACSN 11579131 12417340 15079071 15187187 15279786 15337521 15536066 16007092 16713974 17303408 17550372 17565603 17660363 18590585 19171876 19879327 20144767 23430059 7575488 8383323 9743347
SGK1 CREB1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 15733869 2052361 18088355 10826704 7608156
CREB1 RELA â—¼   DOWN_REGULATES ✅ - 21.0 1.0 ACSN 11579131 12417340 15079071 15187187 15279786 15337521 15536066 16007092 16713974 17303408 17550372 17565603 17660363 18590585 19171876 19879327 20144767 23430059 7575488 8383323 9743347
SGK1 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 11175347 12356771 15733869 8887554 9528766 11018520 11698596 11160957 11969286 12235136 7958915 9829964 9687510 18088355 11909979 8688081
CREB1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16611888 25241761 21295542
ESR1 RARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 8300756 8912864 8732679 11038749 15831516 15870697 10076999 9626663 18414489
ESR1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 20080630 16115928 22787161 12750288 20696891 17681750 17699779
ESR1 RARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 17641689 15831516 9717844 9841885
JAK2 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 27468692 27494834 25038756 24469040 30159126
TP53 GADD45A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 10749144 22801474 11221850 15031557 22262183 10321740 17700520 11420680 10094833 23114628 8892753 23948959 9405685 21394211 9931282 10435630 12007564 15721278 17440969 23576563 9566896 9233781 21836608 21245169 15186775 17063488 9154806 10327059 9191059 17344317 9519881 20797428 18350249 7624148 10566557 17084916 16714289 20840860 15735726 12806965 18225552 16581545
TP53 GADD45A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16990795 15603758 14627995
GADD45A MAP3K4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17145710 12052864 9827804
GADD45G MAP2K3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11175814 21614932 12738796 11274345 12213961 18855897
GADD45G MAP2K6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17145710 11175814 21614932 12738796 11274345 12213961 18855897
GADD45G MAP3K4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17145710 12052864 9827804
NFKB1 IKBKG â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 9315679 9914500 9721103 10593898 9135156
RELA IKBKG â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 9315679 9914500 9721103 10593898 9135156
REL IKBKG â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 9315679 9914500 9721103 10593898 9135156
IKBKG RELA â—¼   ENZYMATIC_REACTION ✅ 38.0 1.0 ACSN 11280761 11438547 11460167 12133805 12811837 14660645 15145317 15199157 15485931 15536066 15573129 16818229 16970925 17237376 17254973 17301840 17363905 17485448 17693255 18264787 18716620 19833085 20138012 20300203 21133840 21217011 21232017 21807870 22435554 23086447 23422957 23430059 24378531 24699077 24766893 24958845 2649237 28462531
PIAS4 IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 19917246 20932475 20301198
NFKB1 IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14743216
IKBKG NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14743216
NFKB1 IL12A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 14568984 11602633 17982049 17579043 15871905 18690006 19164128
RELA IL12A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 14568984 17982049 17579043 20876114 19122653 22070873 18690006 19164128 19185846
REL IL12A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 12820969 11602633 14568984 17982049 22893703 17892401 20876114 25565375 21402701 19122653 15871905 16166378 19185846
IL12A IL12RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23331499 11086056 7911493 11114383 12023369 8943050 7527811
IL12A IL12B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 17145710 10779781 10899108 8943050 7527811
REL IL12B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 11058167 10657616 10940886 17982049 9464836 7565674 14976188 15251981 12077291 17291992 16688168 9497375 17579043 18523276 15482860 19299558 22427889 16166378 15270850 20876114 25565375 9808189 20145200
RELA IL12B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 27.0 1.0 Omnipath 12820969 14688340 20221401 11058167 10657616 10940886 19122653 18690006 11792125 19624579 17982049 9464836 17924060 7565674 14976188 15251981 12077291 17579043 24012417 19299558 16166378 12517966 17635610 24184907 15270850 20876114 9808189
NFKB1 IL12B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 14688340 11058167 10657616 10940886 18690006 11792125 17982049 9464836 17924060 7565674 14976188 9234715 12077291 9497375 17579043 19299558 22427889 16166378 15270850 9808189
IL12B IL12RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 11086056 7911493 7843232 8943050 7527811
TYK2 IL12RB1 â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 10807786 11867689 12244147 12372421 14610620 15546391 19833085 20406969 21042762 21115385 22077060 24091328 24204259 27216177 7543512 8683106 8700208 9834059
JAK2 IL12RB1 â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 10807786 11867689 12244147 12372421 14610620 15546391 19833085 20406969 21042762 21115385 22077060 24091328 24204259 27216177 7543512 8683106 8700208 9834059
JAK2 IL12RB1 â—¼   SHARES_COMPLEX 18.0 1.0 ACSN 10807786 11867689 12244147 12372421 14610620 15546391 19833085 20406969 21042762 21115385 22077060 24091328 24204259 27216177 7543512 8683106 8700208 9834059
TYK2 IL12RB1 â—¼   SHARES_COMPLEX 18.0 1.0 ACSN 10807786 11867689 12244147 12372421 14610620 15546391 19833085 20406969 21042762 21115385 22077060 24091328 24204259 27216177 7543512 8683106 8700208 9834059
IL18 IL18RAP â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 10679398 11274345 11592085 12620219 12682231 14504095 14660645 14662834 15099563 15802534 16878026 17704786 23681101 23811849 26885855 27048821 27066895 9469432
IL18 IL18R1 â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 10679398 11274345 11592085 12620219 12682231 14504095 14660645 14662834 15099563 15802534 16878026 17704786 23681101 23811849 26885855 27048821 27066895 9469432
IL18 IL18R1 â—¼   SHARES_COMPLEX 18.0 1.0 ACSN 10679398 11274345 11592085 12620219 12682231 14504095 14660645 14662834 15099563 15802534 16878026 17704786 23681101 23811849 26885855 27048821 27066895 9469432
IL18 IL18RAP â—¼   SHARES_COMPLEX 18.0 1.0 ACSN 10679398 11274345 11592085 12620219 12682231 14504095 14660645 14662834 15099563 15802534 16878026 17704786 23681101 23811849 26885855 27048821 27066895 9469432
TYK2 IL18 â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20856220 21115385 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 7543512 9834059
JAK2 IL18 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 9834059
IL18 IL18R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 25261253 9792649 12096920 11046021 9325300
IL18 IL18RAP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9792649
IL18RAP IL18R1 â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 10679398 11274345 11592085 12620219 12682231 14504095 14660645 14662834 15099563 15802534 16878026 17704786 23681101 23811849 26885855 27048821 27066895 9469432
JAK2 TYK2 â—¼   PHYSICAL_INTERACTION 73.0 1.0 ACSN 10485906 10807786 11160275 11306493 11371360 11867689 11870632 12223527 12244147 12372421 12401408 12496409 12754507 12818165 1439146 14610620 14657224 15099563 15356132 15546391 15573129 16243976 16413922 17404308 17485448 18209571 18250477 1825141 18451175 18555777 18555778 19581928 19833085 20138012 20184663 20406969 20510870 20856220 21042762 21097505 21115385 21469115 21840487 22077060 22595692 23034983 23124025 23390297 23567181 24011634 24030977 24091328 24204259 24346288 24418198 25002027 25582338 26201938 26268945 26755705 27216177 27557510 2965306 7512720 7521688 7543512 7590867 8683106 8700208 8837607 9535722 9834059 9845545
JAK2 TYK2 â—¼   SHARES_COMPLEX 73.0 1.0 ACSN 10485906 10807786 11160275 11306493 11371360 11867689 11870632 12223527 12244147 12372421 12401408 12496409 12754507 12818165 1439146 14610620 14657224 15099563 15356132 15546391 15573129 16243976 16413922 17404308 17485448 18209571 18250477 1825141 18451175 18555777 18555778 19581928 19833085 20138012 20184663 20406969 20510870 20856220 21042762 21097505 21115385 21469115 21840487 22077060 22595692 23034983 23124025 23390297 23567181 24011634 24030977 24091328 24204259 24346288 24418198 25002027 25582338 26201938 26268945 26755705 27216177 27557510 2965306 7512720 7521688 7543512 7590867 8683106 8700208 8837607 9535722 9834059 9845545
JAK2 STAT3 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 11867689 14610620 19833085 20237318 20406969 20581311 21840487 22754783 24091328 27216177 7512720 7521688
JAK2 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 167.0 1.0 Omnipath 10918587 8272872 16319070 18718905 15592455 34066153 23166634 33986510 17389395 29162862 29449694 33512408 21098725 9083098 17565041 27748760 27344175 34031055 29290793 21285325 33846242 33774038 9566874 25962054 20826784 14551213 26188635 26008966 15284024 26175413 21481791 33774344 26307676 9305919 10925297 15615703 12626508 16497976 32087696 16469875 31914141 23331499 11350938 28978186 16306356 33824475 18988627 17401459 19147545 15151905 12637586 34433042 8626374 15950906 27181202 24793791 20455003 21575192 32094172 15322111 17016520 34247191 19901323 12626585 27086926 21166956 23906537 31976162 9211920 12576423 22306293 10207096 12075083 11294897 26787900 12244095 14701810 33909625 11803465 17360477 28827891 33820781 19159681 18939995 11445068 27941883 11429593 30054295 26675255 11850821 9582023 34067421 34707127 15786731 25986861 27351213 34118143 15077188 26699492 12595539 21071413 18498667 22153071 15156153 33513694 25915428 11940572 12529382 18525315 24501689 33839684 24316223 19834108 9575217
KAT5 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 12551922 16713569
KAT5 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17188038 15310756 18280244 16601686
MAP3K4 MAP2K3 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 11175814 11274345 12738796 16799472 18855897 21614932 23850759 24104473
MAP3K4 MAP2K3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 9305639 25241761 21614932 12738796 11274345 9841871 15866172 18855897
MAP3K4 MAP2K6 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 11175814 11274345 12738796 16799472 18855897 21614932 23850759 24104473
MAP3K4 MAP2K6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 17145710 9305639 12052864 23331499 25241761 17726008 21614932 12738796 11274345 9841871 15866172 16157600 18855897
RELA NFKB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 16778171 20427719 23362108 16513645 1740105 20596645 16513841 19469019 8454856 21420936 16135789 9417120
NFKB1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10348347 11032029 8051093 12145335 20097177
NFKB1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 88.0 1.0 Omnipath 17145710 16209943 25609649 8428580 12947093 16970925 17072323 2050119 15657065 21270162 11976329 16793322 21544861 22261743 8657102 9824778 11880271 9450761 17962807 21988832 25355951 9722548 18215660 14743216 15799966 10799898 16105840 15218526 8798655 14690596 22139845 22808155 11571291 17072327 16740634 10498867 8255759 8246997 15214841 16846590 15371334 16285893 17072322 17855547 18321863 16493424 7479976 15145317 17561400 20110362 9426183 23687337 12414801 11970949 20154269 20237821 24175631 24634218 34100597 14645533 17982102 21763497 16204234 9437432 20547752 15818410 7628694
PPARD PPARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18445701 19483106 11867749 16288226
PPARA PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12941763 16226723 20706641 17261671 18769491
RXRA PPARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 10195690 12562861 16189514 11237216 10708554
RXRA PPARD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 22205725 23331499 15604093 9933587 19756148 11237216 15888456
RXRA PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 56.0 1.0 Omnipath 12763030 25609649 20211142 11877444 16504037 17579352 16713569 9065481 22205725 23331499 22363753 10854698 19147680 19043829 12591919 9568716 10882139 10935544 17980149 26260846 21478865 14587029 23711995 9121466 18217139 31547433 7838715 19047629 23275339 21833030 12966085 17312272 11237216 15888456
RARA RXRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 50.0 1.0 Omnipath 15528208 19345331 16713569 16769902 21988832 23331499 14521715 15604093 21071413 10828175 10698945 18988627 12393611 25303530 16224062 25241761 1310351 21478865 17641689 7760852 9415406 9121466 7705655 9582446 15171703 10882070 1314167 12052862 31700049
RELA TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 18269916 10348347 11032029 8051093 20061391 15155458 21332394 9890939 21887328
RELA SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20617556 15152190 24064732
SIRT1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 19408108 25217963 15152190 21081649
STAT3 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19345327 12057007 23335796 16713569 18448488
VDR RXRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 48.0 1.0 Omnipath 14726489 16357103 17786964 16750418 11514567 20564192 11149488 12796488 21988832 12847098 23331499 15604093 10037600 11094341 9632709 20153625 21478865 10733574 11124027 15829977 10224118 17500032 15805579 22179700 15888456 15647825 11075811
TP53 SGK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9058378 18430410 19756449 8647846
SIRT1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 18235502 11672523 18235501 15205477 35931247 15989956 17964266 25280219 19047049 16713569 19960022 21245319 12006491 19590512
TYK2 STAT3 â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
TYK2 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 29145629 21098725 12626585 10542297 23331499 15261459 8662928 30910759 23673666 14565860 12023369 30029643 14764663 18389480 23124025 25516297
TP53 ZNF579 â—¼   KO_UP_REGULATES ✅ + 1.96 1.96 PKG 28854368