GRB2
|
ABLIM1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5216105
12577067
|
GRB2
|
DNM2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
15834155
5217666
|
TSC1
|
LZTS2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
3002166
21653829
|
TSC1
|
GCC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
3002166
21653829
|
FBF1
|
MAP3K5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
000924
30021884
|
TSC1
|
NRBF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
3002166
21653829
|
TSC1
|
GPATCH1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
3002166
21653829
|
TSC1
|
FBF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
3002166
21653829
|
SORBS1
|
DNM2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
6804237
19116150
|
SNX9
|
DNM2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5217519
15703209
|
RAB7A
|
DNM2
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
20711168
8045116
|
DNM2
|
SNX9
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
5217519
15703209
|
NEDD1
|
HAUS6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
0901587106
19369198
|
CUL4B
|
DCUN1D1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
807.0
|
0.8
|
STRING
|
36370105
|
SNX9
|
DNM2
|
â—¼ COLOCALIZATION
|
✅
|
|
0.81
|
0.81
|
mint
|
5217519
15703209
|
CUL4B
|
RBM14
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
21145461
28225217
|
RAC1
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
31980649
|
LZTS2
|
FBF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
25416956
26638075
|
LZTS2
|
ADIP
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
TXLNA
|
IFT74
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
RAB2A
|
RAC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
31871319
26344197
|
HIF1N
|
TXLNG
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
FBF1
|
ADIP
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
25416956
26638075
|
MGST3
|
NMT1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
CCP110
|
CEP290
|
â—¼ PHYSICAL_INTERACTION
|
|
|
828.0
|
0.82
|
STRING
|
36370105
|
CTBP1
|
RBM14
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
31041561
30217970
|
HIF1N
|
TXLNA
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
29426014
|
PCM1
|
HAUS3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
34079125
24981860
26638075
|
PCM1
|
HAUS6
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
34079125
24981860
26638075
|
PCM1
|
HAUS8
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
34079125
24981860
26638075
|
PCM1
|
CEP97
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
24421332
34079125
26638075
|
PCM1
|
PLK1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
34079125
23345402
26638075
|
CUL1
|
CUL3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
840.0
|
0.84
|
STRING
|
36370105
|
HAUS8
|
HAUS6
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.85
|
0.85
|
mint
|
24981860
|
CUL3
|
CUL1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
21145461
26344197
|
OFD1
|
CSPP1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
26496610
26638075
|
ADIP
|
OFD1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
26496610
26638075
|
DCUN1D1
|
LZTS2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.86
|
0.86
|
HuRI
|
32296183
|
CUL1
|
FBXL12
|
â—¼ PHYSICAL_INTERACTION
|
|
|
865.0
|
0.86
|
STRING
|
36370105
|
CSPP1
|
PCM1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
28514442
34079125
26186194
26638075
|
HAUS6
|
HAUS3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
19369198
24981860
20360068
|
HIF1N
|
FBF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
28514442
16189514
33961781
26972000
|
OFD1
|
PCM1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
34079125
24089205
26496610
26638075
|
IFT81
|
PCM1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
28514442
26638075
33961781
26186194
34079125
|
PCM1
|
NEDD1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
34079125
26496610
26638075
|
CEP97
|
NEDD1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
33961781
26496610
26638075
|
OFD1
|
C2CD3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
24997988
26496610
|
HAUS3
|
HAUS6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
870.0
|
0.87
|
STRING
|
36370105
|
CAND1
|
DCUN1D1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
874.0
|
0.87
|
STRING
|
36370105
|
TXLNA
|
TXLNG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
877.0
|
0.87
|
STRING
|
36370105
|
TJP1
|
TJP2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
878.0
|
0.87
|
STRING
|
36370105
|
PLK1
|
CEP97
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
19596235
32707033
25659891
|
PLK1
|
OFD1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
26638075
21988832
|
TXLNA
|
TXLNG
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
28514442
33961781
27173435
22939629
21903422
|
ADIP
|
PCM1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
34079125
26638075
24397932
|
HAUS6
|
HAUS8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
880.0
|
0.88
|
STRING
|
36370105
|
CCP110
|
CEP97
|
â—¼ PHYSICAL_INTERACTION
|
|
|
886.0
|
0.88
|
STRING
|
36370105
|
GCC1
|
FBF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
16189514
16713569
26638075
|
CEP290
|
CCP110
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.89
|
0.89
|
mint
|
22441691
8392017
|
RAB7A
|
RAB2A
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
34079125
26344197
26496610
|
IFT81
|
IFT74
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
28514442
32296183
33961781
27173435
26186194
|
DNM2
|
SNX9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
893.0
|
0.89
|
STRING
|
36370105
|
CBL
|
SORBS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
894.0
|
0.89
|
STRING
|
36370105
|
CAND1
|
CUL4B
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
31973889
28225217
26496610
25435324
12504026
12609982
21145461
34026424
|
PLK1
|
TP53BP2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
PLK1
|
CEP192
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
26012549
25042804
|
CUL2
|
DCUN1D1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
899.0
|
0.9
|
STRING
|
36370105
|
CAND1
|
CUL2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
21249194
21778237
12609982
12504026
18173839
22405651
|
CUL3
|
DCUN1D1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
899.0
|
0.9
|
STRING
|
36370105
|
CAND1
|
CUL1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
17079684
17290223
12504025
25435324
12504026
12609982
17439941
21145461
22474075
23019411
28715492
22767593
17438373
12706828
23453757
22013077
18173839
22405651
16036220
29499133
21249194
18826954
21169563
15537541
21778237
27542266
29103612
16861300
12684064
|
CAND1
|
CUL1
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
3.0
|
0.9
|
ACSN
|
12504025
12504026
15537541
|
CUL3
|
CAND1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
21249194
16449638
22013077
12609982
21145461
22405651
26286618
|
FAS
|
MAP3K5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
25241761
11495919
|
HAUS6
|
HAUS8
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
19369198
25173975
24981860
20360068
|
DNM2
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
903.0
|
0.9
|
STRING
|
36370105
|
PLK1
|
CCNB1
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.91
|
0.91
|
Signor
|
11242082
|
GRB2
|
CBL
|
â—¼ RELOCALIZATION
|
✅
|
+
|
0.91
|
0.91
|
Signor
|
11823423
|
GPATCH1
|
WDR83
|
â—¼ PHYSICAL_INTERACTION
|
|
|
914.0
|
0.91
|
STRING
|
36370105
|
CAND1
|
CUL3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
917.0
|
0.91
|
STRING
|
36370105
|
HK1
|
RHOC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
932.0
|
0.93
|
STRING
|
36370105
|
CAND1
|
CUL2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
938.0
|
0.93
|
STRING
|
36370105
|
CEP97
|
CCP110
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.95
|
0.95
|
mint
|
22441691
8392017
|
GRB2
|
CBL
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.96
|
0.96
|
mint
|
5220480
7642581
|
CUL1
|
CAND1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.96
|
0.96
|
mint
|
17290223
5219620
|
CAND1
|
CUL4B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
962.0
|
0.96
|
STRING
|
36370105
|
IFT74
|
IFT81
|
â—¼ PHYSICAL_INTERACTION
|
|
|
984.0
|
0.98
|
STRING
|
36370105
|
CUL1
|
DCUN1D1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
995.0
|
0.99
|
STRING
|
36370105
|
CAND1
|
CUL1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
996.0
|
0.99
|
STRING
|
36370105
|
CBL
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
STAM2
|
CBL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
24828152
12686592
12551915
15828871
19109251
|
CBL
|
STAM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
24828152
12686592
12551915
15828871
19109251
|
GRB2
|
CBL
|
â—¼ PROTEIN_INTERACTION
|
|
|
1.0
|
1.0
|
HIPPIE
|
31980649
8649804
8995445
25036637
23799367
11997436
8943292
9242692
10570290
8662998
11399323
10086340
7642581
9108392
20936779
11133830
8626404
17094785
8063801
9129019
8900205
15210722
8621483
25872741
25814554
9178909
16906159
8950973
17971399
10025673
9295052
19380743
9716598
16713569
11964172
9234717
8083187
7537740
8824292
9259313
9311917
7791764
17072306
14725908
33627783
9461587
9434624
9851874
8695851
12839496
17944804
11792427
10204582
8621719
11823423
9541596
33961781
169092
11263968
98621719
28514442
18273061
7592693
9174058
21706016
8995358
9872323
9233773
9367879
7544353
12941616
10829062
20124286
917890
15677445
9092538
10521482
8647120
19836242
|
GRB2
|
CBL
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
26.0
|
1.0
|
ACSN
|
10086337
10426994
10567412
10811803
10982827
11447289
11777939
11777960
11907067
12175651
12640133
15536084
15567848
15574420
16339513
16582911
16713974
16887996
17070508
17100878
17496910
17673906
18490724
19449109
26552706
8551221
|
SORBS1
|
CBL
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
15128873
9447983
17548467
12504111
12765336
11001060
|
CBL
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
158.0
|
1.0
|
Omnipath
|
11823423
8621483
9242692
18273061
17635922
16906159
8626404
8662998
9108392
9541596
98621719
9295052
25872741
17372273
8824292
8943292
12941616
20124286
19531499
10086340
8063801
9129019
9590251
11263968
9461587
7642581
10521482
10204582
8995445
8900205
7592693
9716598
8083187
14725908
17904548
7791764
9178909
25036637
8695851
19836242
7537740
15210722
9108316
169092
9311917
10514377
9092538
17072306
19380743
9872323
9234717
11997436
23799367
9434624
16713569
10829062
9367879
11964172
12839496
15677445
9851874
11792427
17094785
20936779
10570290
917890
17944804
25814554
17971399
11133830
8950973
21706016
8995358
9233773
10025673
8621719
11399323
9259313
9174058
8649804
|
DNM2
|
CLTC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
8.0
|
1.0
|
Reactome
|
10480952
7650016
7592972
10593899
14731593
2121367
9497313
8939989
|
DNM2
|
CLTC
|
â—¼ GTPASE_REACTION
|
✅
|
|
7.0
|
1.0
|
Reactome
|
10480952
7650016
7592972
10593899
2121367
9497313
8939989
|
STAM2
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
24828152
12686592
12551915
15828871
19109251
|
GRB2
|
STAM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
24828152
12686592
12551915
15828871
19109251
|
GRB2
|
RAC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
32.0
|
1.0
|
ACSN
|
10086337
10567412
10811803
10982827
11274345
11447289
11756498
11777939
12040186
12175651
12640133
12738796
14585353
15567848
15574420
15863030
16102570
16582911
16887996
17496910
17673906
18000759
18855897
19151919
19449109
19568798
21614932
24027568
26552706
27331412
7510700
8551221
|
GRB2
|
RAC1
|
â—¼ SHARES_COMPLEX
|
|
|
32.0
|
1.0
|
ACSN
|
10086337
10567412
10811803
10982827
11274345
11447289
11756498
11777939
12040186
12175651
12640133
12738796
14585353
15567848
15574420
15863030
16102570
16582911
16887996
17496910
17673906
18000759
18855897
19151919
19449109
19568798
21614932
24027568
26552706
27331412
7510700
8551221
|
PLK1
|
CCNB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
26.0
|
1.0
|
Omnipath
|
20404109
16854412
26899266
19364923
25362646
20126263
12524548
26729093
11242082
12447691
|
CAND1
|
CUL1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
45.0
|
1.0
|
Omnipath
|
17145710
12684064
25435324
36076154
23019411
18826954
17290223
17438373
21169563
27542266
16036220
21145461
21778237
22474075
22767593
16861300
18173839
12504026
12504025
12706828
22405651
21249194
23453757
22013077
17439941
12609982
15537541
|
TSC1
|
RAC1
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
11.0
|
1.0
|
ACSN
|
11955434
12829230
12906785
15611338
15851026
15967165
16636147
17680028
18974095
19022819
20146692
|
SNX9
|
DNM2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
27107012
15703209
15299020
18388313
|
PRKACA
|
LASP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
14.0
|
1.0
|
Omnipath
|
12571245
15465019
12432067
22665060
26061439
25225353
|