Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
SUMO1 ATM â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
CDC37 TBK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
PARP1 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7986053 19779455
PARP1 NFKB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
PARP1 TRAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
PARP1 TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
SUMO1 PARP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19622798
PRKDC NFKB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TANK SUMO1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21212807 8142110
SUMO1 NFKB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18617892 6804701
TRAF2 TANK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
UBB TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
UBB NFKB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
UBB TAB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
UBB TRAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
RNF31 TAB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16260783 16953224
TAB2 MALT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17948050 6177522
MALT1 TAB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17948050
CYLD RIPK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 19131965 23010170
CYLD RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17981138 19131965
TRAF2 TBK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TRAF2 BIRC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
UBC SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6504434 17936276
NCOA3 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16877447 20305690
NFKB1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18031796
NFKB1 RIPK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19693652
NFKB1 BIRC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9294162 9733516
BIRC3 BIRC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23070005 18485876
MAVS CYLD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18636086 6804508
TBK1 CYLD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18636086 6804508
UBC CYLD â—¼   DEUBIQUITINATION ✅ 2.0 0.8 intact 19373254 7288828
RIPK2 CYLD â—¼   DEUBIQUITINATION ✅ 2.0 0.8 Reactome 12917691 15620648
IRAK1 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218906 16884718
UBC TBK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18636086 6804508
UBC NFKB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18617892 6804701
UBC TNIP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19373254 7288828
TNIP2 NFKB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
BIRC3 RIPK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21931591 19464198
CYLD UBC â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
SUMO1 IKBA â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 19625650 9734360 10085161 23604351 23284737
MALT1 TRAF2 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 15125833 19234489 16713569
CBP SRC â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 16860316 15615775 16713569 22364282
TAB2 UBB â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
EGFR CNTN2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 20029029 31980649
EGFR PARP1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24780295 28065597
IKKB FKBP5 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33961781 21903422
FKBP5 NEMO â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33961781 25036637
NEMO KEAP1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 20600852 30500824
IKKA KEAP1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 20600852 30500824
SQSTM PARP1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31536960 28796254
PARP1 TRI29 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 26381412 20211142
NFKB1 PRKDC â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 14743216 25609649
BIRC3 SUMO1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30948266 21988832
EPAS1 SUMO1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 20026589 20661221
TRAF6 CACO2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33815386 21988832
IKKB CSN3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23636414 19656241
TNAP3 UBB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
BCL10 IKKA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 11113112 22547678 14695475
CYLD TAB2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 27591049 31762063
TAB2 MALT1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17948050 25748427
IKKA RIPK1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 10980203 29955050
RIPK1 HS90B â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22939624 14743216
TNAP3 SRC â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
SHRPN MALT1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 27070702 33329596
M3K7 MALT1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17948050 25748427
NFKB1 HSP71 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 14743216 25609649
MAVS CYLD â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 18636086 30410068
CYLD K2C8 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 27591049
IRAK1 IKKB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 11096118 18180283
IRAK1 IKKA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 11096118 18180283
NFKB2 UBC â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 14743216 18617892
SYNCI TNIP1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
TNAP3 SQSTM â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33545068 28574503
CACO2 SQSTM â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21079414 33545068
RB6I2 NEMO â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 20932476 15218148
IKKB RB6I2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 20932476 15218148
F196A NEMO â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
T2EA NEMO â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33961781 20211142
SYNCI NEMO â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
NEMO SDCG8 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
NEMO CACO2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33815386 21988832
NEMO CENPF â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
NEMO ZPR1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
CNTN2 IKKB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 16424386 17891179
F196A IKKA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
CNTN2 IKKA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 16424386 17891179
SYNCI M3K7 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
SYNCI CACO2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
TNAP3 CACO2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30561431 33545068
RNF31 UBB â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
CDC37 FKBP5 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 33961781 25036637 24981860
KEAP1 HS90A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 20864537 24127568 26517842
NEMO SNW1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 32296183 32805409 20211142
IKKA TANK â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 12133833 30561431
TANK BIRC2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 30561431 33961781 23524849 21903422
TRAF6 UBC â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 14743216 17703191 19820695 18239685
TRAF6 BIRC3 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 20097753 24464131 23524849 29545793
TNR3 UBB â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
BIRC2 BCL10 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16775419 33961781 10753917
RIPK1 TAB2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 18299187 16603398 29955050 15327770
RIPK1 CYLD â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 17981138 21408173 33654169 22848449 28900035
TRAF2 CACO2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16189514 16713569 33545068
TRAF2 HS90B â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 14743216 25241761
TRAF2 CIKS â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16189514 16713569 15485634 21822258 30892082
BIRC2 RNF31 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 24726327 30561431 27545878 23524849
TNR3 RNF31 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
RNF31 TNAP3 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 30561431 27545878 23032187 23032186
RNF31 CYLD â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28189684 27591049 27545878 27458237 27307491 26670046
MALT1 CAR11 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 31961340 33329596 22528498 25748427 17948050 23322406
BIRC2 M3K14 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 25246529 20184394 18022362
TNAP3 TBK1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 30561431 19615732 15661910 21885437
TBK1 HS90B â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 22939624 14743216
TPM1 NEMO â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
TNR1A BIRC3 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 19815541 18939944 15310755 30420664
RIPK2 TNR1A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16189514 9642260
NEMO CBP â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 14597638 11971985
UBP10 NEMO â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 24270572 25861989
TP4AP NEMO â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16189514 14585990
TNR3 NEMO â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
PPM1B NEMO â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16189514 14585847
ZFAN5 NEMO â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16189514 14754897
TNFA NEMO â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 34315543 27560715 20005846 27307491 33815386 16603398 23104095 23032186 30420664 30561431 26670046 23032187
INHA NEMO â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
NEMO TRI29 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 27695001 20211142
NEMO CNTN2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 33362245 16424386 16611882 17942533 17891179 19064727
TP4AP IKKB â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 32889079 14585990
PPM1B IKKA â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 25241761 14585847
TNR3 SHRPN â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
TNR3 HOIL1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
NFKB1 TNIP2 â—¼   PHYSICAL_INTERACTION 831.0 0.83 STRING 36370105
CYLD TRAF6 â—¼   PHYSICAL_INTERACTION 833.0 0.83 STRING 36370105
IRAK1 CDC37 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 32707033 15647277
PRKDC PARP1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 16794079 9398855 21575865 20085707
TANK ZC12A â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 16189514 25861989
RIPK2 TRAF6 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 16189514 9642260 18329614 21097508
BCL10 BIRC3 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
TRAF2 TAB2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 14633987 17384642 10882101 19150425
NEMO RPAP3 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 20098747 21184742
SRC IKKA â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 12707358 15749833
NEMO AKT1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 20098747 20837477
NFKB1 HS90B â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 14743216 25241761 25609649
BIRC2 TNR3 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28514442 33961781 26186194 12571250
IKBA UBC â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 17318178 18539148
M3K7 UBC â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 16845370 19820695
TBK1 SQSTM â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 32835772 27035970 25972374 33545068 31810986
BIRC3 NEMO â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 18931663 23524849
CBP IKKB â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 14597638 25241761 11971985
NEMO TNR1A â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 16189514 10755617 30420664 30561431 27552911
RB11B NEMO â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 11495908 26496610
MAFIP NEMO â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 21109981 21988832
IKKB HS90B â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 14743216 25241761
M3K7 HS90B â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 32707033 14743216
CYLD RIPK1 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
BIRC3 TRAF6 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
UBB UBC â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
BIRC2 UBB â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
RIPK1 TAB2 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
CYLD RNF31 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
NEMO ATM â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 20065354 30254148 28202068 24457965 18583959 16497931 32731169
SUMO1 NEMO â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 20932475 21811235 21212807 16360037 21777808 16906147 14651848 18583959
NEMO FADD â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 21458669 30561431 16227629
NEMO TAB2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 23986494 17626013 21988832
CYLD TRAF2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 27591049 12917691 23405219 28900035
TNFA RNF31 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 24726327 32968279 23732909 20005846 23746843 27545878 27307491 33815386 31898971 23955153 23032186 30420664 30561431 26670046 23032187 32019898
HS90B SRC â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 32707033 28215707 31980649
SRC IKBA â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 28514442 12429743 9792645 33961781 26186194 8797825
AKT1 CBP â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 19995607 23434580
M3K7 CYLD â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 29291351 27591049 32410369 18332137
HS90A IRAK1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 32707033 15647277
NEMO UBC â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16874300 14743216 17363905 19373254
MAVS NEMO â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 23028469 24379373 21903422 20161788
TNIP1 NEMO â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 21988832 18212736 30561431 20010814
NEMO M3K7 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 34535633 23986494 21606198 17363973 30404796 19531477 33139544 32731169
PPM1B M3K7 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 11104763
TNFA SHRPN â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 32968279 27560715 27545878 27458237 27307491 31898971 23955153 23104095 23032186 30420664 30561431 26670046 23032187
TNFA HOIL1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 25911380 27545878 20005846 27307491 31898971 23955153 23104095 23032186 30420664 26670046
TNFA TNAP3 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 22099304 32968279 25911380 27545878 32599618 27307491 23032186 30561431 26670046 23032187
TAB2 TRAF2 â—¼   PHYSICAL_INTERACTION 851.0 0.85 STRING 36370105
ATM PRKDC â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 10608806 10464290
MCM7 HS90B â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 22863883 23764002
SUMO1 PARP1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 23871147 15576338 19779455 15561718 19596686
NEMO PRKDC â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 14743216 31932854
NFKB2 SUMO1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 18617892 24654937
TRAF6 SRC â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 10635328 16189514 22447928 29545793
BIRC3 BCL10 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 10753917 16395405 33961781 11466612 16775419
BCL10 IKKB â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 11113112 19118383 14695475 17213322
TAB2 HSP71 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 14743216 33961781
TAB2 HS90A â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 14743216 19875381
RIPK1 HSP71 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 14743216 33961781
TRAF2 NEMO â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 10980203 28249776 31502302 23007157 12867425
SRC IKKB â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 12707358 15749833 12645577 15456896
SRC NEMO â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 23131831 15749833
NEMO MALT1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 19494296 27070702 18931663 25748427 18212736 17948050
NEMO BIRC2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 20932475 23732909 12867425 22990857 23524849 30561431
NEMO PP1G â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 14743216 24586659
PP1G ACTG â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 21382349 26496610
M3K7 HSP71 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 14743216 33961781
M3K14 HSP71 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 14743216 31980649
HS90B HSP71 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 22939629 16263121
ZC12A NEMO â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 24270572 25861989
NEMO CAR11 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 17363905 16301747 18625728 15184390
NEMO CCAR1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 28514442 14743216
NEMO ACTG â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 14743216 30561431
NEMO UBP18 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 26240016 14743216
CIKS IKKA â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 12943667 10962033
IKKA HS90B â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 14743216 33961781
SHRPN TNAP3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 30561431 23032186
UBP10 ZC12A â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 24270572 25861989
TNAP3 HOIL1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 23105109 23032186
AKT1 CDC37 â—¼   PHYSICAL_INTERACTION 869.0 0.87 STRING 36370105
EGFR TNR1A â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24658140 25402006 31980649
NEMO MCM7 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 14743216 20098747
NEMO PARP1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 14743216 25735744
PARP1 NFKB1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 16204234 11590148 25609649 16799643
TRAF6 TRAF2 â—¼   PHYSICAL_INTERACTION ✅ 0.87 0.87 mint 8153045 21516116
NEMO UBB â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 14743216 33961781
TNR1A UBB â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 14743216 33961781
UBB CACO2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 25416956 33961781
TNAP3 RIPK1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 29274253 32015333 22585859 19131965 15258597 18246070 30561431
RIPK1 M3K7 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 16543241 21606198 24434549 18570872
NEMO SENP2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 21777808 20098747
SQSTM NEMO â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 16874300 24270048 29255244
K2C8 NEMO â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 20098747 21988832
NEMO PP2AA â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 16129692 16126728
PP2AA IKKB â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 16129692 16126728
M3K14 M3K7 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 10807933 10094049
TRAF2 TRAF6 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
MAVS TRAF2 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
MALT1 TRAF6 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
BIRC2 TRAF2 â—¼   UBIQUITINATION ✅ - 0.87 0.87 Signor 20651737
CDC37 AKT1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 22504172 12176997 31980649 24869908
M3K7 FKBP5 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 32707033 14743216 33961781
FKBP5 IKKA â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 14743216 33961781 25036637
MCM7 IKBA â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 14743216 32912968
AKT1 PRKDC â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15678105 15262962
CBP SUMO1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28630323 23395904 27129204
TRAF2 TRAF6 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 32296183 16189514 16260598 21782231 16713569 25416956 9500555 33961781 21516116 21903422
M3K14 TRAF6 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16189514 25241761 9275204 10921914 16286467 11278268
CSN3 NEMO â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11418127 16189514
BCL10 TRAF2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 32296183 25416956 16713569 10753917 25910212 33961781 11466612
TNFA RIPK1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 34315543 31898971 16603398 33469115 32968279 21620750 30420664 27560715 27458237 22028622 25911380 27545878 21331077 24726327 22099304 12887920 20005846 32599618 27307491 24980434 23955153 23104095 12753742 22675546 26670046 23032187
RIPK1 HS90A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 22939624 14743216 16968706 10744744
TP4AP TRAF2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16876162 16189514 16713569 14585990
TRAF2 ACTG â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 14743216 30561431 25241761
PP1G RPAP3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 28561026 33961781 26186194 30344098 24366813 28330616
TNFA BIRC2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 25911380 12887920 20005846 27307491 32968279 21822306 30561431
TBK1 CYLD â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 18636086 25923723 29755980
SQSTM IRAK1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 34079125 10747026 12034707
TNIP1 UBC â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
NFKB2 TNIP2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 14743216 27609421
NFKB2 NEMO â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 14743216 21131783
HS90A TBK1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 22939624 14743216 16394098 20628368
TBK1 MAVS â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 23028469 16153868 32366851 28346439 21813773 29125880 32511263 24643253 25636800 33372174 21903422 29743353
CACO2 MAVS â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 33577621 31304625 21903422
BIRC3 RIPK2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 9705938 19464198 21931591
RIPK2 NEMO â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 18079694 16189514 10880512
EPAS1 NEMO â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 26500060 15653678
NEMO IKBB â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 14743216 33961781 11485410 21862596
NEMO RB11A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 18685082 17030804 26258637
NEMO HS90A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 14743216 16189514 11864612 26496610 33961781 19875381
NEMO A16L1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 29634390 14743216
CIKS IKKB â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 12943667 10962033 24561578
IKKB HS90A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 14743216 19786027 11864612
IKKA HS90A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 14743216 11864612 22384180 33961781 19875381
RB11A RB11B â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 22939629 33961781
MAVS TBK1 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
IRAK1 TAB2 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
M3K14 CDC37 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 14743216 25036637 31980649 32707033 30833792
EGFR CDC37 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 25036637 31980649 12471035 24189400 23956138
EGFR NEMO â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24658140 25402006 31980649
EGFR AKT1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24658140 25402006 31980649
SENP2 SUMO1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11997515 14673145 17099700 12192048 15896780 15296745
SUMO1 TNR1A â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10187798 8906799 16189514
MALT1 TRAF6 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 19234489 25569716 15125833 22528498 29953499 23264041 17948050
NEMO TRAF6 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 20932475 28249776 23986494 18617513 27695001 30254148 18180283 15125833 25400026 28214532 25548215 30404796 30913450 17728323 17135271 24270048 27929056 20529958
TRAF6 SQSTM â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16189514 30281815 10747026 23017601 15870274 27458013 19903815 31281713 15340068 11244088 17389358 23911927 19201866 32265222 27681126 26279575 16874300 32384667 20974803 28244869
TRAF6 TNAP3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 23737552 23018911 21220427 29720226 23105109 28244869 11463333 9928991 15334086 31625129 32015333 20622874 18164316
RIPK1 FADD â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11854271 23972990 24098568 33469115 11002422 26733177 19524513 26865630 32296183 22864571 27560715 23744296 32024820 21183682 30561431 21052097 19373245 24577083 21458669 21737329 32707033 21525013 22848449 29497034 33961781 26186194 26972597 21620750
TAB2 IRAK1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24735611 23986494 19675569 18180283 11518704 12242293
BIRC2 RIPK1 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
RIPK1 BIRC2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 26612615 21931591 27197231 29021293 19854138 23972990 18570872 30561431 21113135 29955050
RIPK1 SQSTM â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 32707033 10356400 26416459
RIPK1 BIRC3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 21931591 23972990 33526051 18570872 21113135 16547522
RIPK2 TRAF2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 9705938 16189514 16713569 32707033 21903422
MAVS TRAF2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 32296183 27348524 16153868 31806368 30527812 29125880 33582548 32877691 26221961 21516116 31390091 30561431 21903422
TRAF2 TNFA â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 15485837 25911380 12887920 20005846 27545878 27307491 24980434 16603398 23955153 32968279 21822306 30420664 30561431
TRAF2 M3K7 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 32024699 14743216 26299341 17384642 14633987
NEMO RNF31 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24469399 28249776 23732909 23986494 26577923 21811235 19675569 21455180 33815386 29650758 30913450 23032186 30561431 23032187 33215740
HS90A SRC â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16189514 31980649 1310678 16844778 22315411 28537252 32707033
HS90B AKT1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10995457 20650008 31980649
AKT1 IKKA â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 25241761 17962807 10485711 15710601 15800029 10485710 11278366
TNR1A BIRC2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 18022363 19815541 30561431 8943045 32968279 30420664 25681446
RIPK2 BIRC2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 9705938 19464198 16189514 21931591 9642260 30026309
CYLD NEMO â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 15341735 21988832 16627981 31366726 12917690 26802121 12917691 22990857 12917689 30561431
NCOA3 NEMO â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16051665 11971985
TBK1 CACO2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 19820708 33545068 30309841 33961781 32707033 21903422
TNIP1 TNAP3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 32296183 25416956 16713569 10385526 21988832 18029035 12586352 25165885 11389905 12965196 30561431
TNIP2 NEMO â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 30561431 14653779 21988832
TNIP2 TNAP3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10385526 11390377 18029035 21266526 15169888 11389905 30561431
NEMO HSP71 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 14743216 16189514 11877453 16713569
IKBB IKKA â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 14743216 9346485 11485410 33961781 9252186 9689078
TP4AP TNR1A â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16189514 20458742 14585990
TNR1A IKKB â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 21331078 25241761 10755617 31406107 21724995 18949366 11002417 11821416 30420664
CIKS NEMO â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16189514 10962033 12943667 10962024
NEMO HS90B â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 14743216 33961781 26496610 24618592
NEMO SHRPN â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 27893701 28249776 23986494 21709223 21455180 33815386 30913450 23032186 30561431
M3K7 IKKB â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 34535633 31127032 10022904 10779355 18316610 27387502 17363905 24270572 17363973 32410369 27693634 10807933 18456659 26334375 10195894 9689078 21331078 33895773 20932476 11460167 25946971
IKKB TNAP3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 21220427 26649818 11594795
M3K7 IKKA â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16893890 25241761 20200282 33895773 34535633 10094049 10187861 9742107
HS90A M3K14 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 14743216 31980649 22939624 17563756 32707033 30833792
M3K14 HS90B â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22939624 14743216 32707033 31980649
SHRPN HOIL1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24726327 31067453 28978479 21455181 33329596 21455180 33961781 30804189 23032186 33392484 30561431 26670046 34518544
TANK TRAF2 â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
TBK1 TRAF2 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
ATM AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15546863 15899889
SQSTM CDC37 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21900206 32296183 24189400 20562859 34079125
CDC37 NEMO â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 14743216 11864612 25036637 24618592 24189400 26496610 33961781
CDC37 SRC â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 32707033 33961781 31980649 11085988
CDC37 IKKA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 14743216 25036637 11864612 24189400 33961781 32707033 21903422
CDC37 IKKB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 14743216 25036637 11864612 26496610 33961781 21903422
SRC EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 17284441 6169640
EGFR TRAF2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31980649 24658140 23972990 25402006 18271526
EGFR HS90A â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 32669362 20029029 31980649 16849543 12471035 23956138 16024644 24189400 24658140 12006493 25402006
EGFR HS90B â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20029029 31980649 12471035 23956138 24189400 24658140 22939624 25402006 15657067
EGFR HSP71 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20029029 25241761 31980649 24189400 24658140 25402006 15657067
FKBP5 HS90A â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20048054 20661446 25036637 9001212 12538866 22863883 10642522 21235734 21170051 21360678 29079741 23999428 28363942 19875381
FKBP5 HS90B â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 30382094 25036637 21170051
KEAP1 SQSTM â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25416956 23117207 30581152 25939382 31169361 33397898 20495340 28617433 27554286 32296183 20562859 23795962 33545068 30126895 28416489 25505069 24322982 25910212 23242280 21482715 33603948 20421418 26043024 20452972 32075457 19615732 28380357 29033244 28820283 28846113 20173742 20378532 27631370 34079125 24011591 30907226
SUMO1 TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18093978
MAVS TANK â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 19668221 19479062 17327220
TANK NEMO â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 12133833 16189514 21988832 25861989 20484576 33961781 17468758 30561431
TAB2 TRAF6 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11259596 24735611 10882101 12496252 21988832 17720800 18299187 15327770 19675569 18180283 11518704 14633987 12242293 24061540 22924441 19112497 12609980
M3K7 TRAF6 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31127032 22924441 28024152 10921914 27249171 19232515 10882101 16543409 19675569 24434549 10094049 33768585 18758450 19521662 11259596 22851693 19843958 12496252 11518704 14633987 12242293 21822258 19112497 27501752 19820695 16517750 22643835 26038599 31885808 25963657 12609980 31404116
TRAF6 MAVS â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 27348524 16153868 20080758 31806368 22908223 30527812 29125880 23545497 32511263 26385923 26221961 31390091 21903422
TRAF6 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 34938598 19713527
BCL10 TAB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 17158449 15327770 10882101
CAR11 BCL10 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11278692 19815501 21513986 27777308 21157432 18625728 24074955 18806265 19444310 22528498 23690623 25548215 11356195 16356855 19118383 17948050 30279415
MALT1 BCL10 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21157432 31774199 23690623 25748427 17948050 20551178 17189706 21513986 22658522 22267217 14695475 22528498 27070702 31961340 11262391 24130731 27071417 33329596 19444310 27113748 25548215 11090634 30279415 19279678 25569716 18806265 33961781 29953499 19118383 27777308
BCL10 AKT1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16280327 24462114 24412244
BCL10 NEMO â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11113112 17363905 14695475 27070702 23690623 19897484 27777308 18287044 15184390
RIPK1 TRAF2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25416956 24735611 23972990 16603398 8612133 32296183 16291755 11181075 19815541 24434549 30561431 21810480 11479302 31502302 27768232 20577214 25716317 21282461 25882049 8702708 9020361 16713569 29352166 23007157
RIPK1 NEMO â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 24735611 10755617 17702576 26740240 21606198 14653779 16603398 16543241 21113135 16547522 26865630 10980203 23746843 30561431 11262391 32024692 19373245 18029035 31502302 21458669 10880512 18212736 22099304 28249776 21383699 26802121 23104095 27929056
IKKB TRAF2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 32024699 20449947 21782231 16713569 25241761 27387502 19150425 23007157 11359906 18362886
M3K14 TRAF2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9020361 15084608 16189514 23543740 16713569 20184394 25416956 31980649 9275204 25246529 20348096 20385093 11278268
TRAF2 IKKA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20449947 25241761 16713569 23007157 19150425 11359906 9244310
SHRPN RNF31 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 21455181 22791023 22158122 30804189 33392484 34518544 27591049 23746843 21455180 30561431 33215740 31067453 27545878 24141947 33329596 26600301 32019898 28775156 24726327 28978479 27307491 32122970 23104095 33961781 23032186 22253853 26670046
RNF31 HOIL1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 21455181 26577923 22791023 22430200 34518544 21455180 30561431 17006537 33215740 17069764 26525107 26264872 27545878 24141947 33329596 32019898 24726327 29892012 28978479 29997244 20005846 27307491 32122970 32814053 33961781 23708998 26670046 23032187
HS90A RPAP3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21360678 25036637 19875381 24794838
NCOA3 SRC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19305643 12650696 17671194
TNIP2 NFKB1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 14743216 27609421 21988832 15169888 35140242 25609649 29084252
IKKB NFKB1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25241761 16713569 11297557 11976329 10469655 11158290 22536447 12482991
NFKB1 IKKA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 14743216 16713569 11297557 11976329 10469655 25609649 12482991
NFKB1 TNIP1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 14743216 21988832 19695220 35140242 33961781 25609649
NFKB1 NEMO â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 14743216 27609421 15043934 35140242 25609649
NFKB1 BIRC2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 21725609 23178297 23572150
NEMO IRAK1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 24735611 21220427 23986494 18180283 23104095 18347055 17997719
M3K14 NFKB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 14743216 31980649 17563756 11239468 32707033 30833792
IKKB NCOA3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15383283 16051665 16135815 11971985
NCOA3 IKKA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15808510 15383283 16051665 11971985
NEMO TBK1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 23028469 14743216 28514442 20098747 33961781 26611359 30561431 21903422
HS90A HSP71 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 27353360 24949977 11413142 12093808 16263121 21360678 12853476 19875381
IKKB IKBB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 14743216 9346485 33961781 9721103 9689078
TNFA TNR1A â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 25241761 34315543 2848815 26670046 11448951 31898971 9568681 20103630 2170559 33469115 22801493 8182064 32968279 30420664 14743216 9488135 8288897 8805640 27560715 23746843 2170974 22028622 2158863 15173183 19084540 15485837 25911380 27545878 1310388 10634209 24726327 22099304 12887920 24070898 27307491 24980434 33815386 23955153 33961781 20080539 26186194 22675546 12753742 23032187
M3K14 NEMO â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 14743216 16189514 31980649 33961781 32707033 9927690 30833792
NEMO HOIL1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 27893701 28249776 23732909 23986494 21811235 20098747 19675569 21709223 21455180 33815386 30913450 23032186
NEMO IKKB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 23986494 20211142 16611882 20098747 15802604 30913450 16547522 14743216 18450452 10980203 19666608 23131831 21455180 16906147 15184390 24469399 19820708 18462684 31145594 15749833 28249776 24618592 10968790 19422324 30500824 23104095 16938294 31932854 18949366 20167598 16603398 25286246 18583959 24266532 22605335 27426725 26500060 19706536 19365808 18037881 20932476 30404796 16319058 9751060 23506214 25979343 17363973 25400026 22990857 12657630 30561431 12459277 12486103 16583354 29474632 32024699 11971985 11057907 18266467 12133833 24240172 18266324 23016877 21423167 17977820 33961781 20368414 32731169 28514442 25304104 18207244 12612076 19959994 25852190 21903422 29111346 26496610 19656241 17000764 21803029 16497931 20434986 16129692 17568778 11864612 22099304 19815509 17693255 27929056
NEMO TNAP3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 22099304 10755617 33139544 21988832 26802121 11389905 23032186 30561431 31585000
M3K14 IKKB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 14743216 10733566 9346485 9520446 33961781 10195894 32707033 16286467 30833792 11278268
IKKB IKBA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 18202307 11080499 19345327 9914500 26740240 12709429 9346485 16611882 32555320 18723677 22904686 9520446 19959994 12054687 23816567 14743216 16365431 16291755 27497262 27387502 17363905 12624112 18539148 15125833 29650758 28214532 9751059 22990857 26221961 15919917 15125834 18375836 18593939 12486103 19196987 24469399 22037600 25595906 30254148 21399639 22022389 17079871 24912152 15456896 18981174 16286467 12411322 9689078 20434986 12943667 20449947 24618592 25759022 21423167 20797629 15218148 18519641 15217903 24611898 26802121 29958295 16319058 9721103 9891086 21765415
IKBA IKKA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 11042193 17053167 11080499 9914500 9346485 18949366 9520446 15590691 16354686 19959994 12054687 14743216 10733566 17363905 12624112 10094049 24270572 11809792 11940602 9751059 17379600 11113112 12486103 23602409 32912968 15670770 18922877 18003900 17384642 10066434 18074035 18501560 15389589 9252186 16286467 12190313 12411322 9689078 20434986 15310755 20449947 24618592 16219905 12138192 20932476 16493072 11095741 20133937 18519641 29958295 33961781 12730857 26186194 16319058 9721103 9244310 21765415
M3K14 IKKA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 14743216 15084608 25241761 32707033 31980649 10094049 9520446 20348096 15208311 33961781 17563756 9244310 16286467 30833792 11278268 10887201 16498412
BIRC3 TRAF2 â—¼   UBIQUITINATION ✅ - 0.9 0.9 Signor 18997794
TRAF6 IRAK1 â—¼   UBIQUITINATION ✅ + 0.9 0.9 Signor 18347055
TRAF2 RIPK1 â—¼   UP_REGULATES ✅ + 0.9 0.9 Signor 10795740
TRAF2 RIPK1 â—¼   UBIQUITINATION ✅ + 0.9 0.9 Signor 18621737
RPAP3 HS90B â—¼   PROTEIN_INTERACTION 0.91 0.91 HIPPIE 17643375 24794838
TRAF6 UBC â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
TBK1 TANK â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 5220020 17568778
BIRC2 TRAF2 â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
TAB2 TRAF6 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
RIPK1 TRAF2 â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
CBP IKKA â—¼   PROTEIN_INTERACTION 0.93 0.93 HIPPIE 17434128 14597638 11971985 12789342
EGFR SRC â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
CIKS TRAF6 â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 23737552 32350852 16189514 25416956 17277779 22851696 21822258 21516116 25202827 31174059 19825828 12459498 20953186 30892082
MALT1 BCL10 â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 17948050 6177522
TRAF2 TNAP3 â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 10544141 25416956 32296183 24008839 16713569 8692885 30561431
IKBA NFKB2 â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 28514442 14743216 32912968 26496610 33961781 26186194
NFKB2 IKBB â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 28514442 14743216 33961781 26186194
AKT1 HS90A â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 32707033 16189514 21767636 12176997 31980649 25714412 15843522 29311840 22504172 16027165 29139175 12586360 19356729 10995457
NFKB2 IKKA â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 14743216 15140882 17962807 16651533 16303288 21131783 17563756
IKBA IKBB â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 22081069 14743216 28514442 33961781 26186194
M3K7 CDC37 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 14743216 31980649 19026643 33961781 32707033
IKKB KEAP1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 24322982 19818716 27387502 30126895 25926686 30500824 24127568 20600852
IRAK1 TRAF6 â—¼   PHYSICAL_INTERACTION 959.0 0.96 STRING 36370105
FADD TNR1A â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 16611992 15659383 11035039 9129204 8565075
RIPK1 TNR1A â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 24098568 16115877 18949366 19773432 24130170 30420664 21113135 11002422 19524513 8612133 18450452 24758719 29431638 25388546 19815541 28388439 27591049 22817896 28817177 22733818 27552911 18022363 16968706 22179575 19781631 27321185 31406107 15258597 18621737 21737329 20825417 25681446 23429285 16611992 20448643 21331078 18724939 22848449 18939944 7538908 26802121 8985253 33961781
TBK1 TRAF2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 14743216 32707033 20449947 20562859 29125880 23007157 27135603 30420664 33961781 10990461 30561431 21903422 32041822
TRAF2 TNR3 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 12169272 16713569 14517219 20348096 9162022 20732415 26186194 33961781 10799510
TRAF2 TNR1A â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 16189514 25241761 24735611 8943045 32968279 8565075 30420664 8612133 28388439 19815541 29108854 30561431 18776134 22179575 18022363 27321185 31406107 11821416 26212014 16611992 20448643 16713569 20333651 15743837
PP2AA AKT1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 11438723 11839802 20005908 12637511 16044149 20186153 27563096 18191226 26256536
NFKB1 IKBB â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 14743216 27609421 35140242 33961781 26186194
NCOA3 CBP â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 9267036 16713569 11971985 17043108 16227615 9346901 15383283 11823864 9445475 21632823 33589584 9192892 8616895 26267537 11076796 21914189
IKBA NEMO â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 21811235 19959994 16547522 22081069 14743216 26865630 23732909 11830587 21896478 23746843 26496610 17363973 21217772 15670770 18429822 32246052 15749833 15218148 18519641 18957422 16319058 21862596 11064457
M3K7 HS90A â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 32707033 14743216 19026643
TANK TBK1 â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
BIRC2 UBC â—¼   PHYSICAL_INTERACTION 967.0 0.96 STRING 36370105
CDC37 HS90B â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 25036637 28215707 24189400 23428871 26496610 22939624 33961781 27339980 11036079 25486457
CDC37 HS90A â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 24292678 24462205 22939624 14718169 15647277 16335536 21871133 25036637 26496610 21745565 25486457 12176997 22729780 24189400 22504172 22315411 26804907 11413142 12930845 20159553 15001580 19875381 27353360 9685350 33961781 16611982 21360678
SRC EGFR â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 31980649 8845374 21573184 25402006 7506422 10075741 19704002 10971656 23175185 10777553 22227249 20935677 20624308 21268077 17158602 24189400 9020193 16713569 22973453 11983694 24658140 28065597 21278788 17284441 7797556 20333651 7527393 10358079
TBK1 TANK â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 21931555 16189514 31114588 21988832 30420664 21903422 14743216 10581243 29395067 30561431 23286385 27035970 25409927 17823124 32707033 17568778 24488098 23007157 33961781 18307994 29251827
TANK TRAF2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 14743216 16189514 16713569 21988832 20562859 10581243 23007157 12005438 33961781 8710854 10759890 28155233 30561431 21903422
TRAF6 IRAK1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 22033459 24735611 11397809 19716405 17197697 30872404 8837778 10346818 17785851 11960013 18234474 16951688 16024789 11287640 12034707 21220427 23381138 19166926 24434549 28882891 18056395 11259596 23244239 12496252 22447928 20043910 12566447 11518704 12242293 10920205 10383454 18347055 9374458 31921110 14625308
TAB2 M3K7 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 19556242 34535633 31127032 22158122 16603398 16845370 21903422 19955178 19232515 14743216 33717111 10882101 18021073 26432169 31250519 22081109 30348973 20538596 24270572 32303555 24061540 20194509 32410369 28507161 11259596 17384642 19026643 14633987 12242293 27426733 27468689 32707033 25642820 24912525 14670075 8638164 20200282 17158449 12609980 22167179
TRAF2 BIRC2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 16189514 25241761 10753917 21988832 19506082 9384571 8943045 19584093 16263936 21903422 32296183 11181075 19815541 20562859 8643514 15861135 16891304 16282325 30561431 8548810 30359437 11907583 20184394 21331077 25716317 25882049 23524849 27534557 25681446 21653699 16713569 20447407 23007157 20348096 33961781 24276241
TRAF2 BIRC3 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 25241761 30948266 10753917 21988832 9384571 20385093 19815541 20562859 8643514 16891304 16282325 24464131 8548810 11907583 21331077 27534557 23524849 15310755 23543740 16713569 23007157 33961781
NFKB1 IKBA â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 20558726 7891711 27609421 29439025 21988832 7739549 16210649 8631829 35140242 25609649 17003112 9566883 14743216 26496610 8887676 22536447 32912968 9572494 9865693 33572115 20237821 9738011 11313474 20980497 33961781 11020244 26186194
NFKB1 NFKB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 14743216 27609421 21988832 17962807 15169888 35140242 25609649 15660126
NEMO IKKA â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 11080499 21703539 23986494 16611882 25304104 20098747 18949366 18207244 11877453 30913450 12612076 19959994 21903422 22605335 14743216 10733566 10980203 22547678 19666608 23131831 26496610 17363973 21455180 22990857 12244103 26500060 18079694 30561431 12459277 17000764 15184390 12486103 16583354 24469399 18462684 11485410 25355947 11057907 32707033 16497931 15749833 20434986 18266467 32935379 17568778 11864612 17244613 24618592 28249776 23016877 12138192 19815509 17977820 10968790 20368414 30404796 33961781 16938294 16319058 9751060 17728323 27929056 32731169
IKKA IKKB â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 25241761 11080499 9914500 9346241 9346485 11585904 21784860 25852190 25748427 12210728 21903422 14743216 10733566 12244103 9346484 12486103 11971985 21575199 11057907 32707033 16286467 16129692 20434986 11864612 16713569 23016877 20932476 10968790 30500824 17693255 33961781 9751060 16319058 9721103
TNIP2 UBC â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
MAVS TRAF6 â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
HS90A HS90B â—¼   PROTEIN_INTERACTION 0.98 0.98 HIPPIE 25036637 31536960 20353823 26496610 22863883 26344197 33961781 21360678 19875381
RNF31 UBC â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
SENP2 SUMO1 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
TAB2 UBC â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
BIRC3 TRAF2 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
FADD RIPK1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
ATM PARP1 â—¼   ENZYMATIC_REACTION ✅ 54.0 1.0 ACSN 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 9168117 9858600
ATM TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20932475 21872579
ATM PRKDC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 47.0 1.0 Omnipath 17189255 12231622 17303408 24492479 10464290 22230547 15677476 16822724 28985363 29088817 16163361 32868446 19549901 25818648 22923485 19103741 17570479 27939942 19808981 23847781 22355272 24714417 15964794 21376743 31983282 25224041 16908529 12607003 19244120 17525332 15459660 34249431 28107384 12186630 25714019 11877377 26553138 27568553 19535303 15507430 26578593
NFKB1 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 14678988 18367518 12469217 17881446
SRC EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 232.0 1.0 Omnipath 16414009 17081983 25958313 16943190 15618223 19935697 19305428 25402006 24797263 29285309 7488034 15592458 17389395 16461772 20562096 19275932 17897439 15899872 17570479 2803273 23636329 23246962 25505586 23175185 15615697 23349873 16849545 25356505 11983694 24189400 11756413 25748412 26325669 26150526 14512423 18789131 14750954 31978707 25573954 27495374 20071362 18707149 28759036 16729043 26494466 27716204 25537504 17237269 18687633 25884760 29036202 26936397 17575160 20926745 20935677 15282306 23702846 15476828 9069259 19336574 20421302 15660394 23866081 19377510 9777370 22426783 29321659 33706413 25841779 19840943 18669648 12397069 16843263 18957516 34088769 25077442 14963038 19836242 17653080 19625610 16936701 11960379 15548697 18295415 17523611 21268077 20333651 21399647 23376850 11250711 23942551 19704002 22927910 11160627 31952541 10777553 17016520 2543678 19258037 33883672 17646646 28102297 23873690 26771606 21573184 23119029 19151764 16713569 7797556 25955608 15302935 20407013 28513565 23119185 9990038 21080693 20190765 25347738 14630916 15708852 21822308 20628053 25301722 24658140 19690143 27564112 20802523 29124875 33657368 12101233 21787862 14764607 17284441 12878163 26290602 15951569 16543144 15212693 17971399 14523024 10971656 21278788 8845374 22430206 18083107 29641465 18234969 18460189 17551925 22957061 26571308 17043637 20371672 10358079 16799092 19154417 23066441 28065597 12842895 18180459 17158602 18271526 15657067 25159151 34367939 24919575 10075741 25366117 24349301 17561374 16862179 20215522 31980649 24335899 16037379 18451158 14530278 16505275 12063263 23449029 11311660
RIPK1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11116146
EGFR PRKDC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23956138 23178489 18237807 18789131
PRKDC AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 318.0 1.0 Omnipath 27120806 14555685 20028775 20176926 11287317 27542271 26740621 11731414 12393602 34197700 17993646 21940452 21946537 11278872 22975685 16908595 18316359 34073781 24735537 18039660 24652283 20856200 26170313 21300025 15388791 19144640 26297026 17545609 33941854 16280327 10625301 33845796 25918246 34385295 17537996 14645219 20804212 15084259 12169689 21795477 22071574 23913047 34021259 21695150 15684384 33958720 14530366 16670089 19487463 19223464 17303569 25481872 15475446 17116771 28967905 33753495 12438236 29562639 16753042 33836561 19073147 15169778 16891474 19477925 16338973 16397245 34562454 15821749 33767437 34087103 11409731 18381446 15737995 27481935 11313365 26700621 17210635 25447541 33931486 17827393 17126298 15262962 28542588 33574930 11821945 20471940 15461589 17077177 33579227 26921343 17386266 33744230 26848618 12944390 33566837 26902421 21042280 21763421 34380642 18321849 14593122 25775124 25739674 17229808 26351843 24102046 23757022 33532186 16043647 24632620 12781924 25738875 10864894 17974989 25719244 15806160 16497987 25851605 20501647 18439899 28209968 10973320 24819169 25745998 34383763 19592491 19244117 19204084 29088759 26871475 34257082 26755732 17237292 17709744 17640984 34405859 18480058 33995548 22310280 20211239 12052823 22580611 31937616 19920202 26745759 15905173 12499277 15028555 27162341 21106850 33562475 30065170 23462102 15678105 15642728 27065332 28558072 28977846 15319269 21339742 15855334 21045808 20145118 21297104 18632646 17379600 15471950 23474758 26887938 11375271 20013032 18701889 16540596 15314172 28515473 15964826 19638206 25892239 28692056 20530876 27505672 25100728 21242970 17297446 10542266 14670178 15548374 33741342 12429574 11002428 15831486 17116756 25435370 32833881 11402048 25361894 15207915 20729916 15625077 18677106 12869565 11250155 21356307 15967841 31936857 25943101 18394555 12644590 14500543 18691549 27197158 15623569 33477794 12062056 16754797 15383526 21909137 21949775 20085797 16807298 15899889 33868961 23940660 23434580 33927349 23899556 14990993 12000752 27880719 26065416 19060924 34520759 14679308 15334055 17283158 25257795 17548608 30586628 24437487 20124472 15289327 23325788 21208159 33664452 31679687 12791703 15047712 17166829 26146988 17329400 20660158 21532621 21806543 20179209 25661488 20957047 17562705 19915805 12606948 17277771 10377409 25893295 17270736 16407838 20597130 15047168 28658616 16357520 15537647 12818176 11425855 17210830 19800394 12506011 21310961 16963136 21996732 15695828 33835469 11701613 19010331 26686089 28915558 15467762 17586693 18456663 34381564 18765673 20233713 34208786 11029403 22084251 20622007 12077256 11313948 16917505 19448664 27391337 15792956 21172654 15608670 12438239 19875458 22014578 25071014 11809760 18728186 31391321 33891611 19805619 33407730 25868858 25320242 34348155 20832730
SUMO1 SENP2 â—¼   CLEAVAGE ✅ 7.0 1.0 Reactome 16253240 15487983 16738331 12192048 11896061 17591783 14563852
TANK TRAF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 20562859 21988832 21903422 8710854 12005438 14743216 10581243 16713569 23007157 10759890
TANK TBK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 16127453 17568778 27035970 25409927 23286385 18307994 24488098 21419663 21988832 21903422 15210742 14743216 16189514 19820708 21931555 10581243 23007157 17823124 17468758 17327220
TRAF6 IRAK1 â—¼   PHYSICAL_INTERACTION 20.0 1.0 ACSN 11274345 12150927 12620219 12738796 14660645 15125833 16252010 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 23070005 23681101 23811849
TRAF6 IRAK1 â—¼   SHARES_COMPLEX 20.0 1.0 ACSN 11274345 12150927 12620219 12738796 14660645 15125833 16252010 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 23070005 23681101 23811849
TRAF6 MALT1 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 11274345 12620219 14660645 15125833 16252010 17948050 18264787 18758450 18922473 19161412
TRAF6 TAB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11274345 12150927 12620219 14660645 15125833 16252010 17948050 18264787 18758450 18922473 19161412
TRAF6 BCL10 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 11274345 12620219 14660645 15125833 16252010 17948050 18264787 18758450 18922473 19161412
TRAF6 IRAK1 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 11274345 12150927 12620219 12738796 14660645 15125833 16252010 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 23070005 23681101 23811849
CYLD TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 12917691 12917689 16230348 29933112 18382763
IRAK1 TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 66.0 1.0 Omnipath 10346818 17145710 17785851 16024789 14625308 11259596 10383454 18234474 9374458 11287640 23244239 21220427 11518704 19166926 16951367 15894263 10747026 35926385 18056395 12566447 12496252 22447928 12242293 8837778 10920205 11960013 19716405 24735611 20043910 24434549 17785432 11397809 18347055 22033459 12140561 23381138 17197697
TRAF6 TAB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 46.0 1.0 Omnipath 17145710 15492226 19675569 15932500 18180283 16251197 10882101 18299187 11259596 1551980 24061540 21988832 19112497 22924441 11518704 11809792 15836773 14633987 14751757 25290089 12496252 12609980 12242293 24735611 14982987 15327770 17720800
TRAF6 MALT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 15125833 17948050 22528498
RIPK1 FADD â—¼   PHYSICAL_INTERACTION 90.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 1134007 11438547 11460167 11583996 11875494 12215447 12646658 12702723 12724420 12811837 1431106 14607933 14625680 14660645 14730360 14744430 15099563 15592525 15699106 15760909 16406523 16498403 16713974 16940415 17301840 17462996 17916596 18264787 18545270 18633355 18641653 19392652 19411070 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20038811 20184663 20435894 20452955 20531300 21133840 21232017 21411734 21826665 22421439 22427918 22955274 23010170 23069999 23073834 23170255 23377657 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24366341 24378531 24699077 24958845 26024392 26201938 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 8910423 9184224 9217161 9488730 9759866
TRAF2 FADD â—¼   PHYSICAL_INTERACTION 74.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 1134007 11438547 11460167 11583996 11875494 12215447 12646658 12702723 12724420 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 15760909 16406523 16498403 16713974 16940415 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19597341 19632174 19838173 20038811 20184663 20435894 20452955 20531300 21133840 21232017 21411734 21826665 22427918 22955274 23010170 23069999 23170255 23377657 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 27984721 28574505 8910423 9488730 9759866
RIPK1 FADD â—¼   SHARES_COMPLEX 90.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 1134007 11438547 11460167 11583996 11875494 12215447 12646658 12702723 12724420 12811837 1431106 14607933 14625680 14660645 14730360 14744430 15099563 15592525 15699106 15760909 16406523 16498403 16713974 16940415 17301840 17462996 17916596 18264787 18545270 18633355 18641653 19392652 19411070 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20038811 20184663 20435894 20452955 20531300 21133840 21232017 21411734 21826665 22421439 22427918 22955274 23010170 23069999 23073834 23170255 23377657 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24366341 24378531 24699077 24958845 26024392 26201938 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 8910423 9184224 9217161 9488730 9759866
TRAF2 FADD â—¼   SHARES_COMPLEX 74.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 1134007 11438547 11460167 11583996 11875494 12215447 12646658 12702723 12724420 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 15760909 16406523 16498403 16713974 16940415 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19597341 19632174 19838173 20038811 20184663 20435894 20452955 20531300 21133840 21232017 21411734 21826665 22427918 22955274 23010170 23069999 23170255 23377657 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 27984721 28574505 8910423 9488730 9759866
TRAF2 FADD â—¼   ENZYMATIC_REACTION ✅ 74.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 1134007 11438547 11460167 11583996 11875494 12215447 12646658 12702723 12724420 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 15760909 16406523 16498403 16713974 16940415 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19597341 19632174 19838173 20038811 20184663 20435894 20452955 20531300 21133840 21232017 21411734 21826665 22427918 22955274 23010170 23069999 23170255 23377657 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 27984721 28574505 8910423 9488730 9759866
FADD TAB2 â—¼   ENZYMATIC_REACTION ✅ 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
FADD RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 16585540 22864571 26733177 11002422 11854271 19524512 21458669 21525013 21052097 26865630 21741934 23972990 21620750 26186194 27560715 24098568 20203691 16227629 32296183 18485876 32024820 22890322 11464215 21737329 12887920 21183682 19524513 26972597 19373245 22848449 24577083
BCL10 MALT1 â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 11280761 11356195 11460167 12356734 14660645 16809782 16818229 17052756 17301840 17363905 17462996 17948050 18264101 18264787 20685844 21133840 21199863 21232017 21873235 24560716 24699077 24958845
BCL10 MALT1 â—¼   SHARES_COMPLEX 22.0 1.0 ACSN 11280761 11356195 11460167 12356734 14660645 16809782 16818229 17052756 17301840 17363905 17462996 17948050 18264101 18264787 20685844 21133840 21199863 21232017 21873235 24560716 24699077 24958845
RIPK2 BCL10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 14638696 10825200 14695475
RIPK1 TAB2 â—¼   ENZYMATIC_REACTION ✅ 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
TRAF2 TAB2 â—¼   ENZYMATIC_REACTION ✅ 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
IRAK1 TAB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11518704 12242293 19675569 23331499 18180283 21071413 11259596
RIPK1 TAB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15327770 16603398
TRAF2 RIPK1 â—¼   PHYSICAL_INTERACTION 92.0 1.0 ACSN 10465784 10734135 10925299 11003656 11112697 11274345 11280761 1134007 11438547 11460167 11583996 11668179 11875494 12048245 12215447 12556535 12646658 12655147 12702723 12724420 12738796 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15170913 15310755 15592525 15699106 15760909 16406523 16498403 16713974 16940415 17301840 17462996 17496911 17916596 18264787 18292600 18633355 18641653 18855897 19392652 19411070 19524513 19597341 19632174 19838173 20038811 20184663 20435894 20452955 20531300 21133840 21232017 21411734 21614932 21826665 22427918 22955274 23010170 23069999 23070005 23170255 23377657 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 27984721 28574505 28765050 8910423 8974401 9379049 9488730 9582321 9759866
TRAF2 RIPK1 â—¼   SHARES_COMPLEX 92.0 1.0 ACSN 10465784 10734135 10925299 11003656 11112697 11274345 11280761 1134007 11438547 11460167 11583996 11668179 11875494 12048245 12215447 12556535 12646658 12655147 12702723 12724420 12738796 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15170913 15310755 15592525 15699106 15760909 16406523 16498403 16713974 16940415 17301840 17462996 17496911 17916596 18264787 18292600 18633355 18641653 18855897 19392652 19411070 19524513 19597341 19632174 19838173 20038811 20184663 20435894 20452955 20531300 21133840 21232017 21411734 21614932 21826665 22427918 22955274 23010170 23069999 23070005 23170255 23377657 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 27984721 28574505 28765050 8910423 8974401 9379049 9488730 9582321 9759866
TRAF2 RIPK1 â—¼   ENZYMATIC_REACTION ✅ 92.0 1.0 ACSN 10465784 10734135 10925299 11003656 11112697 11274345 11280761 1134007 11438547 11460167 11583996 11668179 11875494 12048245 12215447 12556535 12646658 12655147 12702723 12724420 12738796 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15170913 15310755 15592525 15699106 15760909 16406523 16498403 16713974 16940415 17301840 17462996 17496911 17916596 18264787 18292600 18633355 18641653 18855897 19392652 19411070 19524513 19597341 19632174 19838173 20038811 20184663 20435894 20452955 20531300 21133840 21232017 21411734 21614932 21826665 22427918 22955274 23010170 23069999 23070005 23170255 23377657 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 27984721 28574505 28765050 8910423 8974401 9379049 9488730 9582321 9759866
BIRC2 RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12887920 18570872 20547836 15147886 21931591 16603398 19284370 18621737
BIRC3 RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 18570872 33526051 15147886 21931591 16603398 19284370 18621737
TRAF2 RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 45.0 1.0 Omnipath 8702708 8612133 25416956 16713569 18621737 25882049 16291755 18981220 21741934 21232017 20577214 11181075 10795740 23972990 21119000 15175328 20203691 21810480 21282461 9712898 32296183 23007157 25716317 20448643 12887920 24735611 15258597 24434549 19815541 16603398 11479302 9020361
NFKB1 TRAF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15723831 15041463 19392652 18990758
CYLD TRAF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 12917691 23405219 17851586
TRAF2 BIRC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 18997792 8643514 11907583 16713569 18621737 18997794 21988832 18606850 9384571 16891304 10753917 18981220 24464131 20562859 25241761 23543740 20385093 21331077 23007157 16282325 23524849 8548810 19815541
TRAF2 BIRC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 54.0 1.0 Omnipath 21653699 25681446 8943045 8643514 11907583 16713569 20184394 18621737 18997794 21988832 25882049 9384571 21903422 16891304 10753917 20447407 18981220 16189514 15861135 11181075 20348096 20562859 25241761 19584093 32296183 21331077 23007157 16282325 19506082 25716317 23524849 24276241 16263936 12887920 8548810 19815541
TRAF2 RIPK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 16713569 9705938 21903422
RNF31 CYLD â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 26997266 27591049 27545878 24098568 27458237 27307491 22435550
SRC AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 11445557 25241761 23242524 18283331 12600984
TBK1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21329883 21464307 21106850
AKT1 IRAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 11976320
NFKB1 BIRC3 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 21725609 23178297 23572150 9294162 9733516
NFKB1 BIRC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 15231833 15050749 19343319 17673602 17000776 11880364 10733571 9733516 18566231 12010810 15723831 10823821 11297551
NFKB1 BIRC2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15050749 17673602 12687011 15756023 9733516 12010810 18566231 16453001 20103608
TNIP2 NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 21988832 25609649 14743216 15169888
TNIP1 NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 21988832 25609649 14743216 19695220
BIRC2 RIPK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19464198 16189514 21931591 9642260
MAVS TBK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 21813773 15210743 16127453 33372174 17020950 25636800 21903422 15210742 16753195 16306936 12702806 24643253 16177806 27419230 16153868 16858409 29743353 17468758 17327220