Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
NELFE CDK9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
CDK9 NELFA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
CDK9 NELFCD â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
CDK9 NELFB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
CDK9 SUPT4H1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
EP300 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23403292 24998469
EP300 SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20339243 21467818
EP300 CCNT1 â—¼   ACETYLATION ✅ 2.0 0.8 intact 7265510 19387490
HGS GGA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15611048 5217420
MYC RAN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23468463 11085504
MYC CD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1321339 11266125
CCNT2 NELFA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
SUPT5H NELFA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10916156 12676794
SUPT4H1 NELFA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10916156 12676794
CCNT1 NELFA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
PPIA SUPT5H â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
SUPT5H NELFCD â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10916156 12676794
SUPT5H CCNT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
SUPT5H NELFB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10916156 12676794
SUPT5H NELFE â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10916156 12676794
SUPT5H CCNT2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
GGA2 PIN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
ELL2 RAN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
GRIN2B DLG4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5215250 11937501
DLG4 DLG2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
BICD2 RANBP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1000350 20386726
CCNT1 NELFB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
CCNT1 NELFCD â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
CCNT1 SUPT4H1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
CCNT1 NELFE â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
AP1G1 BICD1 â—¼   COLOCALIZATION 2.0 0.8 intact 17139249 5219394
PDCD6IP CHMP4B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0707601105 18434552
VPS4A PDCD6IP â—¼   COLOCALIZATION 2.0 0.8 intact 17853893 6169256
SOX2 ATOH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22340499 22292066
SOX2 ATOH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15846349
SUPT4H1 NELFB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10916156 12676794
CCNT2 NELFB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
CCNT2 NELFE â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
NELFE SUPT4H1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10916156 12676794
CCNT2 SUPT4H1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
SUPT4H1 NELFCD â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10916156 12676794
CCNT2 NELFCD â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
PLEC MAP1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
APOBEC3G APOBEC3F â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15152192 7600246
CCNT1 MYC â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
ACTA1 ACTB â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
CDK9 PLEC â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22863883 26209609
CDK9 ELL â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 32152128 21729782
ACTB EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33742100 21988832
KAT2B KAT2A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 10373431 24981860
FEZ1 NELFA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
BMI1 PLEC â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24457600 34316702
GGA1 MAP1S â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
BICD1 BICD2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33961781 28718761
RHOB DLG1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
NUFP1 MAP1A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
MLP3B MLP3A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 20562859 24067654
MLP3B MAP1S â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 20562859 31006538
IFT1B MAP1A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
ELL2 CDK9 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 27684187 21873227 32479599 21729782 22483617
AFF4 ELL3 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
ELL3 ELL â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
ELL3 CCNT1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
ELL3 CCNT2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
MYC XPO1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 17314511 26673895 32140074 29467282
NELFCD NELFA â—¼   PHYSICAL_INTERACTION ✅ 0.83 0.83 mint 24981860
BICD1 DISC1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 90000000 31413325 17043677
AFF4 ELL â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 26186194 33961781 21729782
AFF4 CCNT2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 26186194 33961781 21729782
MLP3B MAP1A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 20562859 31006538 18083104
EP300 RAN â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 12649209 33742100
MYC ACTB â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 11839798 29467282
RAN SMARCB1 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
MLP3A MAP1S â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 20562859 21262964
MAP1A RHOB â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 18056259 19637314
NELFB NELFCD â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
CHMP4A VPS4A â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
NELFB SUPT5H â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
CDK9 CCNT2 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 24981860
NUP153 RAN â—¼   PHYSICAL_INTERACTION 849.0 0.85 STRING 36370105
MLP3A MAP1A â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 7908909 20562859 2470876
CHMP4B VPS4A â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
GGA1 GGA2 â—¼   PHYSICAL_INTERACTION 857.0 0.85 STRING 36370105
HGS DLG4 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16713569 12151521
MYC EP300 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15616592 16287840 32140074 16126174 17157259 12776737
HGS GGA2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15611048 19019082
CPSF6 CPSF7 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 26496610 33961781 24981860 22939629
NELFE NELFB â—¼   PHYSICAL_INTERACTION ✅ 0.87 0.87 mint 24981860
ELL2 AFF4 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 32296183 26496610 33961781 26186194 21729782 22483617
MLP3B MAP1B â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 20562859 31006538 18083104 24089205
CDK9 MLLT3 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
AFF4 MLLT1 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
CPSF6 CPSF7 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
AFF4 CCNT2 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
AFF4 MLLT3 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
CDK9 MYC â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
ELL ELL3 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
CDK9 MLLT1 â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
MYC CDK9 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 12944920 19818711 26687678 11673469 17700062 30415952
CD4 CXCR4 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10816381 15660419 14592831
VPS4A VPS4B â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
AFF4 ELL2 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
EP300 KAT2B â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
AFF4 ELL â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
KAT2A MYC â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
CREBBP KAT2B â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
ELL3 MLLT3 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
PDCD6IP TSG101 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
KAT2B EP300 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 8684459 12888487 9267036 12419806 21413932 22384255 20870727 33051058
CCR5 CD4 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10816381 30542158 15660419
GGA1 GGA2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 14638859 33961781 28514442
AFF4 CCNT1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 20153263 33961781 12065898 26186194 21729782 27684187
AFF4 CDK9 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 32707033 21873227 27684187 32479599 20153263 17643375 33961781 12065898 21729782 26186194 23602568 22483617 23455922
EP300 KAT2A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 23667505 23555303 21559432
KAT2A KAT2B â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 23667505 23555303 21559432
KAT2A MYC â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16287840 28628118 10611234 32140074 20691906 35140242 12660246 28205554 17967894
MYC KAT2B â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15572685 35140242 12660246
CCNT1 MYC â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12944920 19818711 11673469 17700062 29467282 30415952
MYC PIN1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 26655473 29467282 15048125 19131971
MYC CXCR4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10229837 11145693
NELFB NELFA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10199401 15489290 11859374
NELFE NELFA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 26496610 33961781 20305087 26186194 24981860 12612062
NELFA NELFB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 26496610 33961781 20305087 24981860 12612062
MAP1LC3B SMARCB1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CCR5 CXCR4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12429730 15660419 18632580
RHOB DLG4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9870943 9870942 16202622
DLG4 MAP1A â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
DLG4 MAP1A â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9786987 11925566
NELFB NELFE â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 10199401 32296183 20211142 14667819 26496610 33961781 20305087 26186194 24981860 12612062 15342491
NELFE NELFCD â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10199401 15489290 11859374
NELFCD NELFE â—¼   PHYSICAL_INTERACTION 909.0 0.91 STRING 36370105
RAN TNPO3 â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
CHMP4A PDCD6IP â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
DLG2 DLG4 â—¼   PROTEIN_INTERACTION 0.93 0.93 HIPPIE 9182804 21653829
NELFA SUPT5H â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
VPS4B VPS4A â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 28514442 11563910 12594041 33961781 26186194
CHMP4B CHMP6 â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
CHMP6 VPS4A â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
SUPT5H SUPT4H1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 24981860
CDK9 CCNT1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 9499409 11145967 15328539 17643375 20562857 9491887 20305087 15713662 19387490 11713532 27684187 14627702 23455922 16980611 26659056 15107825 12588988 12944466 14580347 20153263 22959624 16109377 12115727 21729782 23602568 11282025 30649429 19914168 18483487 24367103 20535204 12832472 19818711 12894230 9872325 23064645 30652970 15713661 21697490 22483617 22939629 32707033 11713533 15528190 15546612 10958691 10617616 10574912 18566585 10465067 24981860 33961781 11689688 17700062 26186194 26344197
CDK9 CCNT2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 32707033 9499409 16331689 18566585 17643375 10465067 33961781 24981860 21729782 26186194 23602568 11282025 27684187 23455922 11713533 26344197
XPO1 RAN â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 32585100 21909257 10779340 10944119 27613868 12070164 20026644 9323133 22939629 26344197
CHMP4B PDCD6IP â—¼   PHYSICAL_INTERACTION 970.0 0.97 STRING 36370105
AFF4 CCNT1 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
CCR5 CD4 â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
NELFA NELFB â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
NELFB NELFE â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
AFF4 CDK9 â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
CDK9 CCNT1 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 6613869 18483487
NELFA NELFE â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
NELFA NELFCD â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
RAN RANBP2 â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
HGS TSG101 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
DLG4 GRIN2B â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
CCNT2 CDK9 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
RAN XPO1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
SUPT4H1 SUPT5H â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCNT1 CDK9 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
CDK9 SUPT5H â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 10757782 16327805 16427012 26399478 11575923 11145967 19941815 25849141
KAT2B EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8684459 14500836 9267036 17496784 20870727
EP300 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 17145710 22290435 19623618 11804596 23343194 22761862 16039586 12776737 17157259 17143292 12660246 15576399 21151179 15522869 17306568 19407812 17666529 21285352 19619488
KAT2A MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11804596 19407812 15522869 12660246
KAT2B CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 9687573 8684459 9687513 9445475 11864601 9267036 17496784
MYC PIN1 â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 11274345 11283614 16713974 16940750 17558397 17873522 19131971 19366350 19751508 19836308 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 22270359 23732914 25002027 26885856
MYC PIN1 â—¼   SHARES_COMPLEX 22.0 1.0 ACSN 11274345 11283614 16713974 16940750 17558397 17873522 19131971 19366350 19751508 19836308 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 22270359 23732914 25002027 26885856
MYC BMI1 â—¼   UP_REGULATES ✅ + 32.0 1.0 ACSN 11274345 11283614 12545156 14536078 15147722 15155580 15279786 17055429 17303408 17550342 17558397 17660363 17873522 18590585 18636226 20027199 20237412 20551172 20581311 20713526 20818389 21406394 21733352 2191300 21919891 22067385 23140366 23869868 25002027 28536364 7575488 9618481
CREBBP MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 7575488 18590585 17303408 15522869 12776737 20144767 17660363 16878156 15279786
PIN1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 26655473 15048125 30723410 23716601
SMARCB1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10319872 14559996 14964309 19234532
XPO1 RAN â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 17081640 15574331 16608852 11231581 9837918 11451485 8113738 11124902 11932251 11289803
RANBP2 RAN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 21988832 24855949 10078529 7603572 20547757 11470507 10318915
CD4 CCR5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17145710 10816381 29637711
DLG4 GRIN2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 20018661 16990796 11997254 9278515 7569905 33000527 11937501 10488080 9581762 11723117 12738960 8601796
DLG4 MAP1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9786987 11925566